Log in

Relevant bibliographies by topics / Ca 19 / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Ca 19.

Dissertations / Theses on the topic 'Ca 19'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 33 dissertations / theses for your research on the topic 'Ca 19.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Zulj, Jelena. "Verifiering av metod för analys av tumörmarkörerna CA 125, CA 15-3 och CA 19-9 på Roche Cobas e411." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-37279.

Full text

Abstract:

Tumörmarkörer är substanser som frisätts i kroppsvätskor från cancerceller. Markörerna används inom sjukvården för att upptäcka och följa upp maligna sjukdomar med analyser av markörerna i serum/plasma. Tre av dessa är cancerantigenerna CA 125, CA 15-3 och CA 19-9. Syftet med studien var att verifiera analysmetoden för tumörmarkörerna CA 125, CA 15-3 och CA 19-9 på två Roche Cobas e411 instrument (instrument 1 och 2) inför införandet av dessa vid avdelningen för klinisk kemi och transfusionsmedicin, Lnadstinget Kalmar län. De av företaget rekommenderade cut-off värdena på Roche Cobas e411 (Roche Diagnostics) är för CA 125 <35 kU/l, för CA 15-3 ≤25 kU/l och för CA 19-9 <27 kU/l. Precisionen beräknades med hjälp av statistiska metoder genom analys av den mellanliggande precisionen (mätning av två kontrollnivåer under 5 dagar) och repeterbarheten (analys av två kontrollnivåer i en serie). En korrelationsstudie gjordes med patientprover som erhölls från Aleris Medilab (Abbot Architect i System). Den mellanliggande precisionenn resulterade i högre variationskoefficientvärden (CV %) för samtliga tre markörer i förhållande till ett åsatt CV från Roche Diagnostics. CV värdet skilde även mellan de två Roche Cobas e411 instrumenten. Repeterbarheten bedömdes vara acceptabel för samtliga tre markörer. Korrelationsstudien visade en skillnad i de uppmätta värdena mellan Roche Cobas e411 och Abbot Architect för samtliga tre markörer. Då Roche Cobas e411 tenderade att ge högre uppmätta värden (kU/l) (54 av 85 gånger). Samstämmigheten mellan metoderna var bra då det endast var två prover vid analys av CA 15-3 och två prover vid analys av CA 19-9 som var på skilda sidor om cut-off värdet. Sammanfattningsvis visade studien att den mellanliggande precisisonen (CV-värdet) för alla tre markörerna var högre än Roche Diagnostics angivna CV värde. Olika CV värden erhölls med Roche Cobas e411 jämfört med Abbot Architect. Olika CV värden erhölls också med instrument 1 jämfört med instrument 2. Precisionen anses vara tillräckligt god för införandet av metoderna i rutinbruk.

APA, Harvard, Vancouver, ISO, and other styles

2

OTTO, JOSIANE. "Elevation du ca 19-9 dans les fibroses pulmonaires idiopathiques." Nice, 1992. http://www.theses.fr/1992NICE6575.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Dericioglu, Mete [Verfasser]. "Die prognostische Relevanz der Tumormarker AFP, CEA, CA 19-9 und CA 125 vor Lebertransplantationen / Mete Dericioglu." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1218077867/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Kritly, Taric. "Etude comparative des marqueurs tumoraux seriques ace, nse, ca 19. 9, ca 125, ca 50 dans les tumeurs solides de l'adulte : a propos de 207 observations." Reims, 1988. http://www.theses.fr/1988REIMM035.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Hartmann, Marie-Thérèse. "Interet du scc ta-4 dans le cancer epidermoide de l'oesophage par rapport a l'ace - ca 19-9 - ca 125." Nice, 1991. http://www.theses.fr/1991NICE6508.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Soares, Andrey Coatrini. "Filmes nanoestruturados aplicados em biossensores para detecção precoce de câncer de pâncreas." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/18/18158/tde-30032017-080111/.

Full text

Abstract:

A necessidade de dispositivos analíticos para detecção precoce de câncer tem motivado pesquisas em nanomateriais de baixo custo, com busca de sinergia para obter alta sensibilidade e seletividade em biossensores. Neste trabalho, o ácido 11-mercaptoundecanóico, o polímero natural quitosana e a proteína concanavalina A (Con A) foram usados como plataforma para imobilizar anticorpos anti-CA 19-9 e construir biossensores para detecção de câncer de pâncreas. Esses biossensores foram produzidos com uma matriz de filmes automontados por adsorção química (self-assembled monolayers, SAM) e por adsorção física (layer-by-layer, LbL). A caracterização com técnicas espectroscópicas e gravimétricas permitiu selecionar as arquiteturas com quitosana/ Con A 2:1 (sensor A), quitosana/ Con A 1:1 (sensor B) e 11-MUA (sensor E), como sendo mais favoráveis à imobilização do anticorpo anti-CA 19-9. Usando os biossensores com espectroscopia de impedância foi possível detectar baixas concentrações do biomarcador CA 19-9, com limites de detecção entre 0,17-0,69 U/mL, 0,31-0,91 U/mL e 0,56-0,91 U/mL para os sensores A, B e E, respectivamente. Esses limites são suficientes para detectar câncer de pâncreas nos estágios iniciais. A seletividade dos dispositivos foi inferida em uma série de experimentos de controle com amostras de células SW 620 e HT-29, ácido úrico, ácido ascórbico, glicose, manose, sérum e antígeno p24, indicando ausência de interferência não específica ao biomarcador. O uso de técnicas de visualização de informação permitiu facilmente distinguir essas amostras, classificando-as de acordo com a concentração do biomarcador em um mapa. Permitiu também quantificar a seletividade dos biossensores através do coeficiente de silhueta, com valores 0,853, 0,861 e 0,897 para os sensores A, B e E, respectivamente. Essa especificidade dos biossensores foi confirmada por medidas de PM-IRRAS, através das bandas de amida I e II em 1566 cm-1 e 1650 cm-1, indicando a interação específica entre anticorpo e antígeno, que pode ser modelada com uma isoterma de Langmuir-Freundlich. Quando a matriz de quitosana/ Con A foi substituída por um filme monocamada ou quando se empregou um biomarcador de maior peso molecular, a adsorção do biomarcador foi explicada por uma combinação de dois processos de Langmuir-Freundlich. Conclui-se que os biossensores de baixo custo podem ser eficientes para diagnóstico e prognóstico, e serem implementados na rede nacional de saúde com disseminação da tecnologia.
The need of analytical devices to detect cancer at early stages has motivated research into nanomaterials where synergy is sought to achieve high sensitivity and selectivity in biosensors. In this work, 11-mercaptoundecanoic acid, the polymer chitosan and the protein concanavalin A (Con A) were used as a platform to immobilize the anti-CA 19-9 antibody using the self-assembled monolayer (SAM) and the layer-by-layer (LbL) techniques. The characterization with spectroscopic and gravimetric techniques allowed us to select the architectures with chitosan/Con A 2:1 (Sensor A), chitosan/Con A 1:1 (Sensor B) and 11 MUA (Sensor E) as optimized for immobilization of anti-CA 19-9 antibodies. Using impedance spectroscopy, the biosensors were capable of detecting low concentrations of CA 19-9 biomarker, with limit of detection in the range 0.17-0.69 U/mL, 0.31-0.91 U/mL and 0.56-0.91 U/mL for sensors A, B and E, respectively. These limits are sufficient to detect pancreatic cancer at early stages. The selectivity of the biosensors was inferred in a series of control experiments with cell samples SW-620 and HT-29, uric acid, ascorbic acid, glucose, mannose, serum and p24 antigen, indicating the absence of non-specific interference. With information visualization techniques, these samples could be easily distinguished in a visual map, and be classified according to their content of CA 19-9. Furthermore, the selectivity could be quantified through the silhouette coefficient, with values 0.853, 0.861 and 0.897 for sensors A, B and E, respectively. This biosensor specificity was confirmed with PM-IRRAS measurements by monitoring the amide I and II bands at 1566 cm-1 and 1650 cm-1. The specific interaction between antibody and antigen was modeled with a Langmuir-Freundlich isotherm. When the chitosan/Con A matrix was replaced by a SAM monolayer or if a larger biomarker was employed, adsorption was explained by a combination of two Langmuir-Freundlich processes. In conclusion, low cost biosensors may be effective for diagnostics and prognostics, and may be further implemented in the Brazilian national health system with technology transfer.

APA, Harvard, Vancouver, ISO, and other styles

7

BILDSTEIN, LAURE. "Evaluation quantitative des mucines conjonctivales par dosage du ca 19-9 sur empreintes." Dijon, 1994. http://www.theses.fr/1994DIJOM061.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Dumitra, Sinziana. "CA 19-9 and the McGill Brisbane Symptom Score: predictors of pancreatic cancer survival." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116938.

Full text

Abstract:

Background: Clinical tools that predict pancreatic adenocarcinoma (PAC) survival to help tailor treatments are lacking. Our surgical group has developed a clinical score, the McGill Brisbane Symptom Score (MBSS) that predicts PAC survival in resectable and non-resectable PAC. CA 19-9, a biomarker used in the diagnosis of PAC, has demonstrated increased potential as a predictor of PAC survival.Objectives: To determine if the Pancreatic Adenocarcinoma Survival Score (PACSS), a combined score of the CA 19-9-to-bilirubin ratio and the MBSS, better predicts survival in patients with resectable pancreatic cancer compared to the MBSS alone. Methods: A retrospective chart review of 122 patients treated at the McGill University Health Center (MUHC) and the University Hospital Zurich (UHZ) was undertaken. For all patients we calculated the MBSS and the PACSS at the time of diagnosis and ascertained the 2-year survival. Results: Both the MBSS and the PACSS were strong predictors of survival with Hazard Ratios (HR) of 2.58 (95%CI 1.35-4.91) and 3.06 (95%CI 1.64 - 5.70), respectively. Adding the patient age and sex, two other variables available at the time of diagnosis did not significantly improve the predictive ability of the models containing either the PACSS or the MBSS. Conclusions: Adding the CA 19-9-to-bilirubin ratio to the MBSS to form the PACSS may improve the predictive ability when compared to the MBSS alone. However the overlap in the 95% confidence intervals does not allow us to conclude that the difference is statistically significant.
Mise en contexte : Il existe peu d'outils cliniques permettant de prédire la survie des patients souffrant d'adénocarcinome du pancréas (ACP). Notre groupe a développé un score clinique, le McGill Brisbane Symptom Score (MBSS) permettant de prédire la survie chez les patients souffrant d'ACP resequable et non resequable. Objectifs Cette étude a pour but de déterminer si un score combinant le ratio Ca 19-9 sur bilirubine et le MBSS soit le the Pancreatic Adenocarcinoma Survival Score (PACSS), prédit mieux le survie chez les patients avec un ACP resequable compare uniquement au MBSS. Méthodes Une revue de dossiers rétrospective chez 122 patients traite au McGill University Health Center (MUHC) et au University Hospital Zurich (UHZ) fut entreprise. Pou tout les patients on a calcule le MBSS et le PACSS au moment du diagnostic et avons déterminé la survie a 2 ans. Résultats Le MBSS est un bon prédicteur de survie avec un (HR) de 2.58 (95%IC 1.35-4.91). Le PACSS fut le plus puissant prédicteur indépendant de survie avec un HR of 3.06 (95%IC 1.64 - 5.70). En ajoutant l'âge et le sexe, le pouvoir prédictif des deux modèles n'est pas amélioré. Conclusions En ajoutant le ratio Ca 19-9 sur bilirubine au MBSS pour former le PACSS peut améliorer le pouvoir prédictif compare au MBSS. Cependant du a une superposition des intervalles de confiance, nous ne pouvons conclure sur la significance statistique de cette différence.

APA, Harvard, Vancouver, ISO, and other styles

9

Haas, Michael. "Der prognostische Stellenwert des Tumormarkers CA 19-9 und weiterer laborchemischer Parameter beim fortgeschrittenen Pankreaskarzinom." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-137474.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

BELJIO, KATIA. "Elevation du ca 19. 9 au cours des rhumatismes inflammatoires dysimmunitaires : a propos de six observations." Toulouse 3, 1992. http://www.theses.fr/1992TOU31041.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Lässig, Dorit. "Abschätzung der Therapieeffizienz beim fortgeschrittenen Mammakarzinom mittels der Tumormarker CEA und CA 15-3." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-64461.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

PINGANNAUD, MARIE-PIERRE. "Apport du dosage de l'ace et du ca 19-9 dans le diagnostic des collections kystiques pancreatiques." Aix-Marseille 2, 1992. http://www.theses.fr/1992AIX20812.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Gedova, Polina [Verfasser], and Ulrich [Akademischer Betreuer] Pfisterer. "Gattungsnorm und Regelbruch : Landschaftsmalerei im Diskurs der Bildgattungen, Italien ca. 1500-1650 / Polina Gedova ; Betreuer: Ulrich Pfisterer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://nbn-resolving.de/urn:nbn:de:bvb:19-204086.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Shaltiel, Lior. "In vivo and in vitro analysis of the retinal voltage dependent L-type Ca2+channel Ca 1.4 function." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-185603.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Kraouti, Djamila. "Etude statistique comparative du CA 19-9 et de l'âge en cancérologie digestive : à propos de 168 observations." Montpellier 1, 1988. http://www.theses.fr/1988MON11288.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Marin-Leiva, Javiera, Antoine Jeri-Yabar, Fernandez Wendy Hernandez, and Bello Edwin Damian. "Biliary peritonitis due to a ruptured amebic liver abscess mimicking a periampullary tumor and liver metastases with the elevation of CA 19-9 and CA 125: a case report." S. Karger AG, 2018. http://hdl.handle.net/10757/624724.

Full text

Abstract:

Introduction: An amebic liver abscess is the most common presentation of extraintestinal amebiasis. This condition is the result of a parasite infection caused by Entamoeba histolytica. Materials and Methods: We report a case of a 53-year-old male who presented with abdominal pain in the right upper quadrant, jaundice, and a 10-kg weight loss within a 1-month span. Results and Conclusion: A wide range of symptoms and findings in the imaging tests suggestive of neoplasia, elevated levels of CA 19-9 and CA 125, and the presentation of biliary peritonitis as a complication makes this case a challenge for its approach and management.
Revisión por pares

APA, Harvard, Vancouver, ISO, and other styles

17

Hollis, Hilda. "The phrase "God is one" in the New Testament : a study of Romans 3:30, Galatians 3:20, and James 2:19." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63325.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

LE, GALLIC JOELLE. "Nouvelles methodologies en synthese d'oligosaccharides; preparation du marqueur tumoral ca 19-9 utilisable pour la detection precoce des cancers." Paris 11, 1990. http://www.theses.fr/1990PA112271.

Full text

Abstract:

L'interet biologique des sucres est a present bien etabli et la demande de structures antigeniques est grande de la part des immunochimistes. Nous proposons plusieurs nouvelles methodologies de couplage, efficaces et totalement stereoselectives. Nous decrivons notamment la synthese de beta-glycosides du 2-acetamido-2-desoxy-d-glucopyranose catalysee par le triflate stanneux, ainsi que le couplage de ce meme derive sur une proteine a l'aide d'un espaceur introduit stereoselectivement avec la configuration naturelle alpha. De plus, dans cette premiere partie, des alkyl et thioalkyl sialosides alpha sont prepares par la reaction de williamson, reputee jusqu'alors inapplicable au cas des alcoolates non aromatiques. Dans la deuxieme partie, nous presenterons une synthese originale de l'epitope tetrasaccharidique du marqueur tumoral ca 19-9 (sialyl lewis #a)

APA, Harvard, Vancouver, ISO, and other styles

19

Le, Thi Nhu Van. "Intérêt de l'ACE et du CA 19. 9 pour le suivi des malades sous chimiothérapie pour un cancer digestif." Montpellier 1, 1992. http://www.theses.fr/1992MON11229.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Riehle, Alexander [Verfasser], and Albrecht [Akademischer Betreuer] Berger. "Funktionen der byzantinischen Epistolographie : Studien zu den Briefen und Briefsammlungen des Nikephoros Chumnos (ca. 1260-1327) / Alexander Riehle. Betreuer: Albrecht Berger." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-168793.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

DOREY, LAMARQUE MARIE-PIERRE. "L'elevation serique du ca 19-9 en dehors des neoplasies : etude sur 183 dosages realises dans un service de medecine interne." Saint-Etienne, 1993. http://www.theses.fr/1993STET6229.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Haas, Michael [Verfasser], and Volker [Akademischer Betreuer] Heinemann. "Der prognostische Stellenwert des Tumormarkers CA 19-9 und weiterer laborchemischer Parameter beim fortgeschrittenen Pankreaskarzinom / Michael Haas. Betreuer: Volker Heinemann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1018615482/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Colombie, Alain. "Valeurs et limites de dosage de l'antigène Ca 19-9 dans le diagnostic et la surveillance des cancers du pancréas." Montpellier 1, 1989. http://www.theses.fr/1989MON11012.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Lopes, Roberto Iglesias. "Avaliação dos valores séricos e urinários de CA 19-9 e TGFbeta1 na obstrução parcial e completa de ureteres em ratos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-29042014-101952/.

Full text

Abstract:

Introdução: A alteração dos níveis normais de marcadores séricos e urinários ocorre na presença de dano renal associado à uropatia obstrutiva. Valores séricos e e urinários de TGF beta1 e CA 19-9 ainda não foram avaliados em modelo experimental de uropatia obstrutiva. Material e Métodos: Ratos foram divididos em sete grupos: referência, sham operation, nefrectomia unilateral, ligadura completa de ureter unilateral, obstrução parcial de ureter unilateral, obstrução parcial de ambos ureteres, nefrectomia unilateral associada à obstrução parcial do ureter contralateral. Morfometria renal e ureteral, concentrações séricas e urinárias de TGF beta1 e CA 19-9 e expressão tecidual renal de CA 19-9 foram analisadas. A correlação destes marcadores com os grupos submetidos a obstrução completa, obstrução parcial ou sem obstrução foi realizada. Resultados: Achados anatomopatológicos correlacionaram-se positivamente à intensidade da obstrução ureteral e negativamente aos níveis urinários de CA 19-9. Subexpressão acentuada do CA 19-9 foi observada em unidades renais com obstrução completa. Não foram encontradas diferenças estatisticamente significativas para os marcadores TGF beta1 urinário, TGF beta1 sérico e para o CA 19-9 sérico Conclusões: O CA 19-9 urinário correlacionou-se negativamente com o grau de obstrução ureteral. A análise imuno-histoquímica demonstrou a expressão do CA 19-9 no citoplasma das células epiteliais tubulares, sugerindo produção renal do marcador. O TGF beta1 sérico e urinário não apresentaram modificações de acordo com o grau de severidade e tempo de obstrução, o que pode estar relacionado a remodelamento renal menos intenso em resposta à uropatia obstrutiva nestes ratos
Introduction: Abnormal levels of serum and urinary markers occur in the presence of renal damage associated to obstructive uropathy. Urinary and serum TGFbeta1 and CA 19- 9 have not yet been evaluated in an experimental model of obstructive uropathy. Material and Methods: Rats were divided into seven groups: reference, sham operation, unilateral nephrectomy, complete unilateral ureteral obstruction, partial unilateral ureteral obstruction, partial bilateral ureteral obstruction, and unilateral nephrectomy with contralateral partial ureteral obstruction. Kidney and ureter morphometry, TGFbeta1 and CA 19-9 serum and urinary concentrations and CA 19-9 renal tissue expression were analysed. Correlation of these markers to complete, partial obstruction or unobstructed groups was performed. Results: Pathological findings correlated positively with the degree of ureteral obstruction, but negatively with urinary CA 19-9 levels. Marked underexpression of CA 19-9 was observed in kidneys with complete ureteral obstruction. No statistically significant differences were found for urinary and serum TGFbeta1 and also for serum CA 19-9. Conclusions: Urinary CA 19-9 correlated negatively with ureteral obstruction grade. Immunohistochemistry depicted CA 19-9 expression on epithelial tubular cells cytoplasm, suggesting renal origin. Serum and urinary TGFbeta1 did not show alterations in response to severity and length of urinary obstruction, which might be associated with less intense renal remodeling

APA, Harvard, Vancouver, ISO, and other styles

25

Tripp-Friedrich, Kerstin. "Diagnostik, Therapie und Prognose seltener Pankreastumoren." Ulm : Universität Ulm, Medizinische Fakultät, 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10028614.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Tryon, Denzil Bruce. "Accounting for anxiety : an analysis of an early first-century material ethic from Matt 6:19-34." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/1720.

Full text

Abstract:

Thesis (MTh (Old and New Testament))--University of Stellenbosch, 2006.
This paper undertakes a detailed study of Matt 6:19-34 for the specific purpose of accounting for the unique context and content of the material/financial ethic being articulated here by Jesus. The passage, made up of four pericopes, is located within the first of the five discourses of Jesus recorded in Matthew’s Gospel in which Jesus evidently articulates the ethical standards required of the children of the emerging Kingdom of God. The need for such a study stems from an understanding that the passage, indeed the Sermon as a whole, has been treated by traditional scholarship in a somewhat distanced and abstract manner i.e. it has been read without adequate cognisance being taken of the particular socio-linguistic and socio-historical context in which it was originally formulated and articulated. Relatively recent social-scientific and socio-historical New Testament scholarship, however, has provided a specific set of interpretive tools that enable a modern reader to make a far more dynamic and context-sensitive interpretation possible. Accordingly, this paper undertakes a socio-rhetorical analysis of Matt 6:19-34, together with a social-scientific and socio-historic/financial/religious analysis of the eastern Mediterranean world of late Second Temple times. Together these interpretive tools shed new light on the text and provide the opportunity for re-reading that text in a way that, hopefully, more closely articulates the ethic as an original audience might have heard it. Specifically, the use of these interpretive tools provide insights into why it was that Jesus explicitly prohibited worry, some six times in the passage, amongst the children of the Kingdom concerning the provision of their food, drink and clothing i.e. the tools provide something of an explanation for both the rhetorical force of the ethic and the underlying realities that gave rise to its formulation in the first place. These insights are then applied in an attempt at formulating a dynamically equivalent ethic that might be appropriated and applied by present day children of the Kingdom reading the passage today.

APA, Harvard, Vancouver, ISO, and other styles

27

David, L. Kencik. "The Triumph of the Eucharist in the Paintings for the Sala dell’Albergo and the Sala Superiore in the Scuola Grande di San Rocco by Jacopo Tintoretto (ca. 1518/19-1594)." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1590600384514719.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Miranda, Eduardo de Paula. "Avaliação dos biomarcadores urinários no controle do tratamento de estenose de junção ureteropélvica em adultos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-20052016-160232/.

Full text

Abstract:

INTRODUÇÃO E OBJETIVO: A estenose de junção ureteropélvica (EJUP) é importante causa de obstrução do trato urinário e pode levar a deterioração progressiva da função renal. Há espaço para o aprimoramento de novos métodos diagnósticos capazes de discriminar hidronefrose e uropatia obstrutiva. Acredita-se que os biomarcadores urinários podem fornecer indícios de lesão renal precoce na obstrução urinária. Neste contexto, KIM-1 pode elevar-se na urina por lesão tubular proximal, NGAL por lesão no túbulo proximal, distal ou alça de Henle, CA19-9 por produção excessiva no túbulo obstruído e ?2-microglobulina (beta2M) por injúria ao glomérulo ou ao túbulo proximal. O objetivo do presente estudo foi avaliar as propriedades diagnósticas dos biomarcadores urinários citados em adultos com EJUP, sendo o primeiro estudo na literatura a avaliar tais moléculas nesta população. MÉTODOS: Foram estudados de modo prospectivo pacientes consecutivos acima de 18 anos com diagnóstico de EJUP submetidos a pieloplastia videolaparoscópica de dezembro de 2013 a fevereiro de 2015. Foram excluídos do estudo pacientes com EJUP bilateral, rim contralateral patológico, EJUP em rim único, antecedentes de tratamento cirúrgico para estenose de JUP ou taxa de filtração glomerular inferior a 60 ml/min/1,73m2. Cada paciente forneceu quatro amostras de urina para medição de biomarcadores, uma no pré-operatório e outras com 1, 3 e 6 meses de seguimento pós-operatório. O grupo controle foi constituído por voluntários saudáveis sem hidronefrose à ultrassonografia. RESULTADOS: Foram incluídos 47 pacientes com idade média de 38,6 ± 12,7 anos (intervalo 19 a 64 anos), sendo 17 (36,2%) do sexo masculino e 30 (62,8%) do sexo feminino. O grupo controle foi composto por 40 indivíduos semelhantes ao grupo com EJUP no que concerne idade (p = 0,95) e sexo (p = 0,82). KIM-1 foi o marcador com melhores propriedades diagnósticas, apresentando área sob a curva (AUC) de 0,79 (95% CI 0,70 a 0,89). O NGAL, por sua vez, teve AUC de 0,71 (95% CI 0,61 a 0,83), CA19- 9 teve AUC de 0,70 (95% CI 0,60 a 0,81) e (beta2M) apresentou AUC de 0,61 (95% CI 0,50 a 0,73), sendo o único biomarcador com propriedades inadequadas neste cenário. O KIM-1 foi o marcador mais sensível com o ponto de corte 170,4 pg/mg de creatinina (sensibilidade 91,4%, especificidade 59,1%) e o CA 19-9 o mais específico para o ponto de corte de 51,3 U/mg de creatinina (sensibilidade 48,9%, especificidade 88,0%), enquanto o NGAL foi o que apresentou maior queda após desobstrução, com 90,0% dos pacientes apresentando clareamento superior a 50%. CONCLUSÕES: A avaliação dos biomarcadores urinários é útil no diagnóstico de obstrução em adultos com EJUP submetidos a pieloplastia videolaparoscópica. O KIM-1 foi o marcador mais sensível e o CA 19-9 o mais específico, enquanto o NGAL foi o que apresentou maior que com a desobstrução. Houve queda das concentrações dos marcadores após pieloplastia no período estudado. O papel exato dos biomarcadores urinários no cenário de obstrução em adultos deve ser mais amplamente investigado
INTRODUCTION AND OBJECTIVE: Ureteropelvic junction obstruction (UPJO) is an important cause of urinary tract obstruction and can lead to progressive deterioration of renal function. Thus the development of novel non-invasive methods capable of discriminating obstruction and hydronephrosis may be useful. Elevation of urinary biomarkers may provide early evidence of kidney damage in urinary obstruction. In this scenario, urinary concentrations of KIM-1 may be elevated following proximal tubular injury, while NGAL may increase as result of injury to proximal or distal tubule as well as to loop of Henle, CA19-9 after overproduction in the obstructed tubule and ?2 microglobulin (beta2M) after injury to the glomerulus or the proximal tubule. The aim of this study was to evaluate the diagnostic properties of these urinary biomarkers in adults with UPJO. METHODS: We prospectively studied consecutive patients older than 18 years diagnosed with UPJO undergoing laparoscopic pyeloplasty from December 2013 to February 2015 in our institution. Exclusion criteria included patients with bilateral UPJO, unilateral UPJO with contralateral pathologic kidney, solitary kidney, history of previous surgical treatment for UPJO or glomerular filtration rate below 60 ml/min/1,73m2. Each patient provided four voided urine samples for biomarker measurement, one at preoperative consultation and the others at 1, 3 and 6 months of postoperative follow-up. Healthy individuals with no hydronephrosis on ultrasound evaluation constituted our control group. RESULTS: We included 47 patients with a mean age of 38.6 ± 12.7 years (range 19-64 years), from which 17 (36.2%) were males and 30 (62.8%) were females. The control group consisted of 40 subjects with no statistical difference to the study group regarding age (p = 0.95) and gender (p = 0.82). KIM-1 had an area under the curve (AUC) of 0.79 (95% CI 0.70 to 0.89) and was the biomarker with the best diagnostic properties. CA19-9 had an AUC of 0.70 (95% CI 0.60 to 0.81), NGAL had an AUC of 0.71 (95% CI 0.61 to 0.83) and beta2M had an AUC of 0.61 (95% CI 0.50 to 0.73). KIM-1 was the most sensitive marker with a cutoff of 170.4 pg/mg creatinine (sensitivity 91.4%, specificity 59.1%) whereas CA 19-9 as the most specific one, displaying a cutoff of 51.3 U/mg creatinine (sensitivity 48.9%, specificity 88.0%). NGAL showed the greatest decrease in urinary concentrations after pyeloplasty, in which 90.0% of patients had a clearance greater than 50% in comparison to preoperative values. CONCLUSIONS: The evaluation of urinary biomarkers is useful in the assessment of UPJO in adults undergoing laparoscopic pyeloplasty. Urinary concentrations of CA 19-9, NGAL and KIM-1 were elevated in patients with UPJO and significantly decreased after pyeloplasty. The exact role of those biomarkers in the setting of obstruction in adults should be further evaluated

APA, Harvard, Vancouver, ISO, and other styles

29

Pohančaníková, Nikola. "Vliv onkomarkeru CA 19-9 na prognózu pacientů s karcinomem pankreasu." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-356446.

Full text

Abstract:

Charles University, Faculty of Pharmacy in Hradec Králové Department Department of Biological and Medical Sciences Candidate Nikola Pohančaníková Consultant PhDr. Zděnka Kudláčková, Ph.D. Title of Thesis Influence of tumor marker CA 19-9 for development pancreatic cancer Introduction: Pancreatic Cancer is a serious illness with non - specific initial characteristic symptoms. For most patients, the diagnosis is discovered only at an advance stage when the application of radical treatment is no longer possible. It is assumed that the tumor marker CA 19-9 levels are significant factors for determining diagnosis and prognosis of patients affected by the existence of a pancreatic tumor, particularly during active monitoring of the health condition of the affected patients. Objective: The objective of the research was to verify the significance of the tumor marker level CA 19-9 during the prognosis determination of patients suffering from pancreatic cancer. The objective of our research was simultaneously the comparison and assessment of CA 19-9 levels in individual patients and detection of the prognosis of susceptibility of the patients participating in our group. Methods: A total of 289 diagnosed pancreatic cancer patients were examined during the period between 01.01.2015 - 31.12.2015 in the Hradec...

APA, Harvard, Vancouver, ISO, and other styles

30

Chiang-Chin, Tsai, and 蔡江欽. "Pothological and immunohistochemical study with� Anti-CA 19-9 in intrahepatic bile duct of hepatolithiasis." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/62296216210724361154.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Lehmann, Christiane (geb Gerstlauer). "Analyse prädiktiver Biomarker für therapeutische Strategien bei kolorektalem Karzinom." Doctoral thesis, 2006. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-23950.

Full text

Abstract:

Ziel dieser Arbeit war es, prognoserelevante Faktoren für das kolorektale Karzinom anhand des eigenen Patientengutes zu untersuchen. Insbesondere sollte die prognostische Relevanz der Tumormarker CEA, CA 19-9 und p53 in Bezug auf tumorbedingtes Überleben und rezidivfreie Zeit analysiert werden, um anhand ihrer Ausprägung die Prognose eines Patienten nach primär chirurgischer Therapie besser definieren zu können. Dementsprechend sollte ein möglichst adäquates therapeutisches Vorgehen gewährleistet sein. Bezüglich des tumorbedingten Überlebens wurde anhand des Kaplan-Meier Verfahrens nachgewiesen, dass sowohl das UICC-Stadium als auch die Darmwandinfiltration (T-Status), Lymphknotenbefall (N-Status) und CEA im Serum als hochsignifikante Parameter dienen, wohingegen eine signifikante Einflussnahme für das Geschlecht, Alter, Tumorlokalisation, Grading, CA 19-9 und p53 (Serummessung) auf das Überleben nicht festgestellt wurde. Bei näherem Betrachten der einzelnen UICC-Stadien in Abhängigkeit von CEA war dieser der aussagekräfitgste prognostische Tumormarker (Serummessung, cut-off point >= 5 ng/ml) für Patienten in höherem UICC-Stadium (UICC III). Bei weiterer Betrachtung der einzelnen Subgruppen des UICC III-Stadiums war CEA insbesondere für Patienten in UICC IIIA am relevantesten. Bezüglich der beiden anderen Tumormarker CA 19-9 und p53 konnte mittels der Serummessungen keine Korrelation mit dem UICC-Stadium bzw. auch keine signifikante Einflussnahme auf das tumorbedingte Überleben festgestellt werden. Für die rezidivfreie Zeit zeigten UICC-Stadium, T-Status, N-Status, CEA (Serummessung) und Tumorlokalisation (Kolon/Rektum) eine signifikante Einflussnahme. Tumoren des Rektums hatten ein höheres Risikoprofil als die des Kolons. Die immunhistologische und molekulargenetische Analyse bezüglich aller drei Tumormarker bestätigte das UICC Stadium III als ein Risikostadium. Dabei lies sich entgegen der Serummessungen auch für CA 19-9 und p53 eine stadienabhängige Risiko-Korrelation darstellen. Des Weiteren korrelierte das Auftreten p53 spezifischer IgG Antikörper stark mit der p53 Proteinexpression im Gewebe, was die Annahme eines Zusammenhangs zwischen intrazellulärer Ansammlung von p53 in Tumorzellen und einer humoralen Antwort auf p53 stützt. Mit Ausnahme von CEA, zeigten CA 19-9 und p53 für sich alleine keine Korrelation zwischen erhöhten Serumwerten und/oder der Expression im Tumor und dem postoperativen Auftreten von Rezidiven. Dahingegen wurde erstmals in dieser Arbeit festgestellt, dass Patienten, die mindestens drei erhöhte Parameter (CEA, CA 19-9 und p53) im Serum und/oder im Tumor (Protein- oder Genexpression) hatten, eine höhere Rezidivrate (Lokal-, Metastasen) während der Tumornachsorge (36±6,6 Monate) zeigten; dies unabhängig von ihrem UICC Stadium (UICC I-III). Speziell diese Risikogruppe könnte von einer adjuvanten Therapie profitieren
Background: Prognostic information regarding the risk of postoperative tumor recurrence defined by a profile of serological, morphological and/or molecular markers can have potential value particularly for patients with colorectal carcinoma (CRC) of UICC stage II/III, who may benefit from adjuvant chemotherapy after surgery. Methods: A retrospective study of 783 patients with CRC (UICC I-III) including a subgroup analysis of 116 subjects was conducted to determine preoperative serum CEA, CA 19-9, and p53 serum levels. In addition, protein and gene expression of p53, CEA, and APC was assessed in the tumors of those patients. The values of all serological, morphological and molecular parameters were correlated with clinicopathological characteristics for their predictive value of tumor recurrence over a mean follow-up period of 32±6.2 months. Results: Serum CEA but not CA 19-9 or p53 was a significant prognostic factor for disease free survival along with UICC and T/N-stage. When comparing elevated CEA, CA 19-9, and p53 serum levels with expression of the markers in the tumors, their overall expression was found to be 61.3% in the serum versus 93.5% in the tumor in the analyzed patients (n=116). In particular, all patients in UICC stage I-III that demonstrated at least three elevated markers (CEA/CA19-9/p53) in serum and/or in the tumor presented with tumor recurrence/metastases. Conclusion: Overall increased p53, CEA, and CA 19-9 serum levels and their marker expression in the tumor may be used at the time of removal of the primary tumor for defining patients at risk for tumor recurrence

APA, Harvard, Vancouver, ISO, and other styles

32

Fiala, Luděk. "Role endometriózy v rozvoji dyspareunie a algopareunie." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-438080.

Full text

Abstract:

Endometriosis is defined as the presence of endometrial cells outside the uterine cavity. The underlying symptom is pain, endometriosis is often associated with primary or secondary sterility, and it is assumed to be involved in the development of female dyspareunia and algopareunia. There are many theories regarding the cause of the disease, however, none of them affects the complex state of the disease which occurs in the population according to statistics in 10-15 % of women. In women with a diagnosis of sterility and infertility, the incidence of endometriosis is described in more than 40 %. Also, more than 50 % of women describe the most diverse forms of dyspareunia and algopareunia that affect not only women's own lives but also their relationships. The illness thus becomes important not only from a purely medical point of view but also from a psychosocial point of view. It should be noted that there is currently no known specific laboratory marker to diagnose endometriosis. Likewise, there is no unambiguous solution within the therapy, whether it is conservative, surgical, or combined. An important fact is that endometriosis is diagnosed with a considerable delay, according to statistics; it takes up to 11 years from the discovery of the first, often indefinite symptoms, to the unequivocal...

APA, Harvard, Vancouver, ISO, and other styles

33

Kyyanovska, Luba. "Repräsentation der europäischen Kultur in der Tätigkeit der Gesangvereine in Lemberg (Ende des 19. bis Anfang des 20. Jahrhunderts): Leipzig - Vienna - Cracow - Lviv ca. 1900. At the Crossroads of Music and Culture: Beiträge auf der Tagung Kraków 14. September 2012." 2006. https://ul.qucosa.de/id/qucosa%3A16141.

Full text

Abstract:

Auf dem Territorium des multinationalen österreichischen Kronlandes Galizien und Lodomerien mit seiner Hauptstadt Lemberg (ukrain. L’vìv, poln. Lwów) begegneten und verschränkten sich im 19. und zu Anfang des 20. Jahrhunderts west- und osteuropäische kulturelle Traditionen auf einzigartige Weise.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!