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Dissertations / Theses on the topic 'CA3 pyramidal neurons'

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Published: 14 March 2023

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1

LICHERI, VALENTINA. "Modulation of Hyperpolarization-Activated Cation Currents (Ih) by Ethanol in Rat Hippocampal CA3 Pyramidal Neurons." Doctoral thesis, Università degli Studi di Cagliari, 2015. http://hdl.handle.net/11584/266622.

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It is well established that ethanol (EtOH), through the interaction with several membrane proteins, as well as intracellular pathways, is capable to modulate many neuronal function. Recent reports show that EtOH increases the firing rate of hippocampal GABAergic interneurons through the positive modulation of the hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels. This effect might be consistent with the increase of GABA release from presynaptic terminals observed in both CA1 and CA3 inhibitory synapses that leads the enhancement of the GABAergic system induced by
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2

Dennis, Siobhan Dennis. "An investigation of the effects of oxygen glucose deprivation on glutamate receptor localisation within hippocampal CA3 pyramidal neurons." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544384.

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3

Küffner, Mercedes [Verfasser], and Michael [Akademischer Betreuer] Frotscher. "Ultrastructural analysis of spine apparatus in CA3 pyramidal neurons following single cell electroporation in Synaptopodin Knockout - mice = Elektronenmikroskopische Untersuchung des Spine-Apparats in CA3 Pyramidenzellen mittels Einzelzell-Elektroporation in Synaptopodin-defizienten Mäusen." Freiburg : Universität, 2013. http://d-nb.info/1115495283/34.

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4

Caiati, Maddalena Delma. "Activity-dependent regulation of GABA release at immature mossy fibers-CA3 synapses: role of the Prion protein." Doctoral thesis, SISSA, 2012. http://hdl.handle.net/20.500.11767/4719.

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In adulthood, mossy fibers (MFs), the axons of granule cells of the dentate gyrus (DG), release glutamate onto CA3 principal cells and interneurons. In contrast, during the first week of postnatal life MFs release -aminobutyric acid (GABA), which, at this early developmental stage exerts a depolarizing and excitatory action on targeted cells. The depolarizing action of GABA opens voltage-dependent calcium channels and NMDA receptors leading to calcium entry and activation of intracellular signaling pathways involved in several developmental processes, thus contributing to the refinement of ne
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5

Marissal, Thomas. "Une approche développementale de l' hétérogénéité fonctionnelle des neurones pyramidaux de CA3." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4001/document.

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Les neurones pyramidaux de la région CA3 de l'hippocampe présentent une diversité morphologique, physiologique, biochimique, mais aussi fonctionnelle. Une partie des caractéristiques des neurones étant acquise pendant le développement, nous avons formulé l'hypothèse que la diversité morpho-fonctionnelle des neurones pyramidaux serait déterminée aux stades embryonnaires. Pour tester cette hypothèse, nous avons utilisé des souris transgéniques pour lesquelles l'expression d'un marqueur fluorescent (GFP) est conditionnée par la date de neurogenèse des neurones glutamatergiques. Nous avons enregis
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6

Bialowas, Andrzej. "Nouveaux aspects de la fonction axonale dans le néocortex et l'hippocampe de rat." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5023.

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Le neurone est une cellule polarisée qui se divise en deux compartiments spécialisés : le compartiment somato-dendritique et le compartiment axonal. Généralement, le premier reçoit l'information en provenance d'autres neurones et le second génère un message en sortie lorsque la somme des entrées dépasse une valeur seuil au segment initial de l'axone. Ce signal de nature discrète appelé potentiel d'action (PA) est propagé activement jusqu'à la terminaison synaptique où il déclenche la transmission chimique de l'information. Cependant, la fonction axonale ne se résume pas à la simple transmissio
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7

MANIEZZI, CLAUDIA. "Oxytocin modulates GABAA receptor-mediated inhibition onto CA1 pyramidal neurons in mouse." Doctoral thesis, Università degli studi di Pavia, 2017. http://hdl.handle.net/11571/1203349.

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Oxytocin (OT) is a neuropeptide that exerts different peripheral and central actions. I aimed at characterizing the neuromodulatory effects of OT in the hippocampus. Electrophysiological experiments were performed on mouse brain slices using the whole-cell patch-clamp technique on pyramidal neurons (PYR) and GABAergic interneurons (INs) located in CA1 stratum pyramidale. The effect of TGOT (Thr4,Gly7-oxytocin), a selective OT receptor (OTR) agonist, was first evaluated on spontaneous inhibitory postsynaptic currents (sIPSC) recorded from PYRs in Otr+/+ mice. TGOT caused a significant decrease
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8

Song, Jun. "Neuronal Adaptations in Rat Hippocampal CA1 Neurons during Withdrawal from Prolonged Flurazepam Exposure: Glutamatergic System Remodeling." Connect to Online Resource-OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1177519349.

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Thesis (Ph.D.)--University of Toledo, 2007.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Major advisor: Elizabeth Tietz. Includes abstract. Title from title page of PDF document. Bibliography: pages 88-94, 130-136, 178-189, 218-266.
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9

Nassrallah, Wissam. "Store-Operated Response in CA1 Pyramidal Neurons Exhibits Features of Homeostatic Synaptic Plasticity." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33357.

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Homeostatic synaptic plasticity (HSP) regulates synaptic strength in response to changing neuronal firing patterns. This form of plasticity is defined by neurons’ ability to sense and over time integrate their level of firing activity, and to actively maintain it within a defined range. For instance, a compensatory increase in synaptic strength occurs when neuronal activity is chronically attenuated. However, the underpinning cellular mechanisms of this fundamental neural process remain poorly understood. We previously found that during activity deprivation, HSP leads to an increase in α-amino
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10

Turner, Ray William. "Action potential discharge in somata and dendrites of CA1 pyramidal neurons of mammalian hippocampus : an electrophysiological analysis." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25989.

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The electrophysiological properties of somatic and dendritic membranes of CA1 pyramidal neurons were investigated using the rat in vitro hippocampal slice preparation. A comprehensive analysis of extracellular field potentials, current-source density (CSD) and intracellular activity has served to identify the site of origin of action potential (AP) discharge in CA1 pyramidal neurons. 1) Action potential discharge of CA1 pyramidal cells was evoked by suprathreshold stimulation of the alveus (antidromic) or afferent synaptic inputs in stratum oriens (SO) or stratum radiatum (SR). Laminar profil
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11

Sandler, Vladislav M. "Origin and modulation of action potential evoked calcium signals in hippocampal CA1 pyramidal neurons." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0027/NQ38974.pdf.

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12

Herdman, Anthony T. "Current source density analysis of current sinks in apical dendrites of CA1 pyramidal neurons." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq37548.pdf.

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13

Kortekaas, Phaedra. "Development and function of calcium influx in pyramidal neurons of the hippocampal CA1 region." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/55584.

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14

Knopp, Marcus. "Analysis of spine plasticity in CA1 hippocampal pyramidal neurons employing live cell nanoscopic imaging." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-173975.

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In der Großhirnrinde von Säugetieren befindet sich die Mehrheit erregender Synapsen auf Dornfortsätzen, kleinen dendritischen Ausbuchtungen, die in Größe und Form stark variieren. Die Auslösung aktivitätsabhängiger synaptischer Langzeitplastizität geht mit strukturellen Veränderungen dendritischer Dornen einher. Da das beugungsbegrenzte Auflösungsvermögen konventioneller Lichtmikroskope nicht ausreicht um die Morphologie der Dornen verlässlich zu untersuchen, stellte die Elektronenmikroskopie bisher das wichtigste bildgebende Verfahren zur Erforschung von struktureller Plastizität dar, blieb da
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15

Bannister, Anthony Peter. "The synaptic connections of pyramidal neurones and interneurones in rat and cat neocortex." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446714/.

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The layer 4 neurones of the mammalian primary sensory neocortex comprise diverse functional components for the first stage of cortical sensory processing. Dual intracellular recordings of synaptically connected pairs of neurones with biocytin-filling were used to study intra-laminar layer 4 connections in adult cat and rat slices. Interestingly, all excitatory cells involved in intralaminar layer 4 connections were regular spiking despite burst firing cells comprising 37% of the population recorded. Neuronal morphology and synaptic properties were similar in both species, as were the probabili
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16

Wierenga, Cornelia Jeanette. "Functional interactions between interneurons and the pyramidal cell population in the hippocampal CA1 area." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/62915.

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17

Lombardo, J. "Seizure-induced alteration of Ih properties and its impact on CA1 pyramidal neuron excitability." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1397878/.

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Epilepsy is a neurological disorder characterized by abnormal neuronal excitability which has been suggested to result from altered ion channel activity. Of particular interest are the hyperpolarization-activated cation (HCN) channels which have recently been shown to play an important role in temporal lobe epilepsy (TLE) development. To evaluate how HCN channels are modulated during TLE development, I obtained acute hippocampal slices from appropriate control and “epileptic” rats and recorded the hyperpolarization-activated cation current (Ih) from CA1 pyramidal neurons. My results showed tha
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18

Tjong, Yung-wui. "Mechanisms of attenuated large conductance calcium-activated potassium channel activity in rat hippocampal CA1 pyramidal neurons in chronic intermittent hypoxia." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39793953.

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19

Knauer, Beate [Verfasser], Motoharu [Akademischer Betreuer] Yoshida, and Denise [Akademischer Betreuer] Manahan-Vaugham. "Persistent firing and depolarization block in rat CA1 pyramidal neurons / Beate Knauer. Gutachter: Motoharu Yoshida ; Denise Manahan-Vaugham." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1089005970/34.

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20

Kwag, Jeehyun. "Synaptic control of spike timing and spike timing-dependent plasticity during theta frequency oscillation in hippocampal CA1 pyramidal neurons." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487275.

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Spike timing during oscillation has been suggested to play an important role in hippocampal processing. However, how the hippocampal network and the individual neurons interact to precisely control spike timing when they receive synaptic inputs from two major excitatory input pathways - Schaffer collateral and perforant path - during natural network oscillation is yet unknown. Investigation of spike timing control mechanism would shed light on how the local STDP learning rule could be influenced by different cortical inputs during theta oscillation. Here I used whole-cell path-clamp recording
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21

Knopp, Marcus Verfasser], and Tobias [Akademischer Betreuer] [Bonhoeffer. "Analysis of spine plasticity in CA1 hippocampal pyramidal neurons employing live cell nanoscopic imaging / Marcus Knopp. Betreuer: Tobias Bonhoeffer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1059351234/34.

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22

VITALE, CARMELA. "β3 integrin-dependent regulation of SK channel-mediated Ca2+-activated K+ currents in intra- and extra-telencephalic cortical pyramidal neurons". Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/996218.

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Integrins are cell adhesion heterodimers that mediate cell-cell and cell-extracellular matrix (ECM) interactions. They regulate various cellular functions in the central nervous system such as the localization of ion channels, calcium (Ca2+) homeostasis and synaptic transmission. Impairment of these functions can lead to neurodevelopment disorders such as Autism Spectrum Disorders (ASD). Small-conductance Ca2+-activated K+ channels (SK channels) are responsible for the medium afterhyperpolarization (mAHP) current (mIAHP) that regulates excitability and firing pattern in many neurons. I investi
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23

Maurer, Jana [Verfasser], and Andreas [Akademischer Betreuer] Draguhn. "VEGFD Downregulation in Hippocampal Area CA1: Effects on Dendritic Morphology of Pyramidal Neurons and Network Activity / Jana Maurer ; Betreuer: Andreas Draguhn." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1177690101/34.

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24

Castello-Waldow, Tim Phillip [Verfasser], and Carsten [Akademischer Betreuer] Wotjak. "Stability of excitatory connectivity predicts the probability of CA1 pyramidal neurons to undergo activity-dependent plasticity / Tim Phillip Castello-Waldow ; Betreuer: Carsten Wotjak." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/122609225X/34.

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25

Amalyan, Sona. "Cell- and input-specific expression of the α5-GABAAR in the CA1 area of the mouse hippocampus". Master's thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/32486.

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Dans l'hippocampe, les processus de mémoire et d'apprentissage dépendent fortement de l'inhibition GABAergique, qui est fournis par une population hétérogène d'interneurones (INs) via l'activation de sous-types spécifiques de récepteurs GABA. La sous-unité alpha5-GABAAR (α5-GABAAR) est fortement exprimée dans l'hippocampe de la souris, du singe et du cerveau humain. Il a été rapporté que, dans les cellules pyramidales CA1, cette sous-unité est principalement localisée sur les sites extrasynaptiques, où elle est responsable de la génération de la conductance inhibitrice tonique. Si la sous-unit
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26

Nomura, Izumi. "Mechanism of impairment of long-term potentiation by amyloid β is independent of NMDA receptors or voltage-dependent calcium channels in hippocampal CA1 pyramidal neurons". Kyoto University, 2008. http://hdl.handle.net/2433/135834.

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27

Jouvenceau, Anne. "Etude des alterations fonctionnelles des neurones pyramidaux du champ ca1 de l'hippocampe au cours du vieillissement cerebral. Participation relative des deficits cholinergique et calcique." Paris 6, 1997. http://www.theses.fr/1997PA066395.

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Si les connaissances relatives au vieillissement du systeme nerveux central ont considerablement progresse au cours des dernieres annees, il reste a determiner si l'une ou l'autre des alterations, apparaissant au cours du temps, est plus determinante dans le dysfonctionnement neuronal. Nous nous sommes interesses aux modifications des proprietes des neurones pyramidaux du champ ca1 de l'hippocampe survenant au cours du temps, et plus precisement a la contribution relative des atteintes cholinergique et de l'homeostasie calcique grace a deux modeles animaux (denervation cholinergique induit par
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28

Fekete, Aurélie. "Les déterminants du seuil du potentiel d'action dans les neurones corticaux." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0459/document.

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Le neurone est une cellule hautement spécialisée qui permet, par des impulsions électriques appelées potentiel d’action (PA) d’assurer la communication neuronale de manière rapide et efficace vers les autres neurones du cerveau. L’axone occupe une place privilégiée dans la genèse du PA. En effet, une région spécialisée de l’axone appelé segment initial de l’axone (SIA) concentre les protéines canaux qui sont à l’origine du PA, les canaux sodium.Le sujet de cette thèse a pour objet d’identifier les facteurs géométriques et électriques contrôlant le seuil du PA. Par une approche essentiellement
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29

Valença, Andreia Barbosa 1987. "Effects of stress on CA3 pyramidal neurons in the pregnant female rat." Master's thesis, 2010. http://hdl.handle.net/10451/2300.

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Tese de mestrado. Biologia Humana e Ambiente. Universidade de Lisboa, Faculdade de Ciências, 2010<br>Stress is one of the primary factors leading to many disorders, including depression, one of the most prevalent psychiatric disorders. Additionally, it has been well documented that hippocampal plasticity is vulnerable to the effects of stress and these effects are often sexually differentiated. Women are twice as likely as men to experience stress-related disorders during the lifespan. In fact, a growing number of women experience psychological stress, such as depression and anxiety, during pr
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30

Ashhad, Sufyan. "Physiological Interactions between Neuronal Active Conductances And Inositol Trisphosphate Receptors in Neurons and Astrocytes." Thesis, 2015. http://etd.iisc.ernet.in/2005/3879.

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Intricate interactions among constituent components are defining hallmarks of biological systems and sculpt physiology across different scales spanning gene networks to behavioural repertoires. Whereas interactions among channels and receptors define neuronal physiology, interactions among different cells specify the characteristic features of network physiology. From a single-neuron perspective, it is now evident that the somato-dendritic plasma membrane of hippocampus pyramidal neurons is endowed with several voltage-gated ion channels (VGICs) with varying biophysical properties and sub cell
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31

Park, Yul Young. "Persistent and transient Na⁺ currents in hippocampal CA1 pyramidal neurons." Thesis, 2011. http://hdl.handle.net/2152/ETD-UT-2011-08-3822.

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The biophysical properties and distribution of voltage gated ion channels shape the spatio-temporal pattern of synaptic inputs and determine the input-output properties of the neuron. Of the various voltage-gated ion channels, persistent Na⁺ current (INaP) is of interest because of its activation near rest, slow inactivation kinetics, and consequent effects on excitability. Overshadowed by transient Na⁺ current (INaT) of large amplitude and fast inactivation, various quantitative characterizations of INaP have yet to provide a clear understanding of their role in neuronal excitability. We addr
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32

Tran, Le Thuy Van. "Dynamics of evoked and spontaneous calcium transients in synaptic boutons of neocortical pyramidal neurons." Phd thesis, 2017. http://hdl.handle.net/1885/133756.

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In response to an action potential (AP), a transient rise in the intracellular calcium concentration ([Ca2+]i) causes transmitter release from nerve terminals. As the spatiotemporal dynamics of this calcium rise can affect the efficacy and plasticity of synaptic connections, it is essential to understand their determinants. To characterise factors that shape calcium transients in neocortical synaptic boutons, layer 5 pyramidal cells in the rat somatosensory cortex were filled through the patch pipette with a fluorescent calcium indicator for the measurement of [Ca2+]i. For accurate calculation
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33

Dickson, Andrea Haessly. "Investigation of firing properties in CA1 hippocampal pyramidal neurons in a mouse model of Fragile X syndrome." 2012. http://hdl.handle.net/2152/20036.

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Fragile X Syndrome is the most common form of heritable cognitive disability. It is caused by a genetic mutation that leads to a lack of protein from the FMR1 gene. This protein (FMRP) is used to regulate the translation of many other proteins, thereby leading to a wide range of effects. Because the origin of this disease is based on the lack of a single protein, an animal model with construct validity can be used to investigate the potential effects leading to the symptoms of the disease. Many studies have investigated the synaptic plasticity differences of CA1 pyramidal neurons between a mo
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34

Srinivas, V. Kalyana. "Epileptiform Activity Induced Alterations In Ca2+ Dynamics And Network Physiology Of Hippocampal Neurons - In Vitro Studies." Thesis, 2008. http://hdl.handle.net/2005/756.

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Epilepsy is characterized by the hyperexcitability of individual neurons and hyper synchronization of groups of neurons (networks). The acquired changes that take place at molecular, cellular and network levels are important for the induction and maintenance of epileptic activity in the brain. Epileptic activity is known to alter the intrinsic properties and signaling of neurons. Understanding acquired changes that cause epilepsy may lead to innovative strategies to prevent or cure this neurological disorder. Advances in in vitro electrophysiological techniques together with experimental model
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35

Sandler, Vladislav Michael. "Origin and modulation of action potential evoked calcium signals in hippocampal CA1 pyramidal neurons." Thesis, 1999. http://hdl.handle.net/2429/10926.

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Calcium is an important second messenger that participates in triggering and regulating numerous neuronal processes. Action potentials (APs or AP) initiate rapid changes of intracellular Ca2+-concentration ([Ca2+];) in both soma and dendrites of central neurons. We addressed two major questions about the origin and modulation of these changes in [Ca2 +]i. Firstly, how does a neurotransmitter, serotonin (5-HT), modulate the backpropagation of APs and associated changes in the [Ca2+]; in CA1 hippocampal pyramidal neurons? Secondly, do APs trigger Ca2+-induced Ca2+-release (CICR) from int
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36

Yeh, Tu-Hsueh, and 葉篤學. "Ischemia-induced Functional Alteration of Hippocampal Glial Glutamate Transporters and mGluR 5 of CA1 Pyramidal Neurons." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/28987134407629006113.

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博士<br>長庚大學<br>臨床醫學研究所<br>93<br>Ischemic stroke is a serious neurological disease. It has been the second leading cause of death in Taiwan after 1983 and the leading killer for those aged over 65. The patients with stroke often have variable functional disability, resulting in many socioeconomic problems. Thus, how to minimize the injury induced by cerebral ischemia and promote functional recovery after stroke has been a great challenge for clinical practice. In the past years, the therapy for stroke is restricted to secondary prevention. Recent advances in searching neuroprotective agents prov
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Ferguson, Katie. "A Mathematical Model of CA1 Hippocampal Neurons with Astrocytic Input." Thesis, 2009. http://hdl.handle.net/10012/4494.

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Over time astrocytes have been thought to function in an auxiliary manner, providing neurons with metabolic and structural support. However, recent research suggests they may play a fundamental role in the generation and propagation of focal epileptic seizures by causing synchronized electrical bursts in neurons. It would be helpful to have a simple mathematical model that represents this dynamic and incorporates these updated experimental results. We have created a two-compartment model of a typical neuron found in the hippocampal CA1 region, an area often thought to be the origin of these se
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Pinheiro, Miguel Maria Restolho Mateus. "Glucocorticoid Effects in the Developing Hippocampus: a Morphometric Assessment." Master's thesis, 2017. http://hdl.handle.net/10316/83373.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>Os mecanismos neurobiológicos subjacentes ao desenvolvimento cerebral dependem da constante harmonia entre os fatores endógenos e exógenos que os coordenam. Em circunstâncias em que o ambiente fetal se encontre alterado, como no caso da exposição a glucocorticoides, o desenvolvimento neurológico poder-se-á desviar do seu curso normal, culminando na formação de cérebros anómalos e disfuncionais.De facto, está extensivamente descrito que a exposição a elevadas concentrações de glucocortico
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Urban, Nicolai Thomas. "Nanoscopy inside living brain slices." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-0023-9921-1.

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