Dissertations / Theses on the topic 'CAD Translation'

There are many different programs that can perform Computer Aided Design (CAD). In order for these programs to share data, file translations need to occur. These translations have typically been done by IGES and STEP files. With the work done at the BYU CAD Lab to create a multi-engineer synchronous heterogeneous CAD environment, these translation processes have become synchronous by using a server and a database to manage the data. However, this system stores part data in a database. The data in the database cannot be used in traditional Product Lifecycle Management systems. In order to remedy this, a new database was developed that enables every edit made in a CAD part across multiple CAD systems to be stored as well as worked on simultaneously. This allows users to access every action performed in a part. Branching was introduced to the database which allows users to work on multiple configurations of a part simultaneously and reduces file save sizes for different configurations by 98.6% compared to those created by traditional CAD systems.

This thesis consists of a free verse translation of Pedro Calderón de la Barca's 1653 play Cada uno para sí. It also includes an introduction by the translator giving a brief history of the play as well as comments on the translation process used in this translation.
Arts, Faculty of
Theatre and Film, Department of
Graduate

The polyglutamine diseases are caused by an expansion of a CAG repeat sequence. This group of late-onset neurodegenerative disorders is characterised by neuronal cell death and the accumulation of polyglutamine-containing proteins. Several molecular mechanisms have been proposed that may explain disease pathogenesis.
In this study, we propose a new pathogenic mechanism for these neurodegenerative diseases. We have demonstrated that expanded CAG stretches are prone to frameshifting to the -1 alanine-encoding GCA frame, and we propose that this phenomenon is due to ribosomal slippage during translation. This slippage depends on the presence of long CAG tracts, and generates polyalanine-containing proteins. We showed that polyalanines increase cell toxicity. Finally, we tested the effects of a ribosome-interacting drug and its ability to reduce or inhibit -1 translational frameshift and hence reduce cell toxicity. This drug introduces an avenue of potential treatment for these disorders.

The concept of translating source code into other target programming languages is extensively used in a wide area of applications. Danfoss Power Solutions AB, a company located in Älmhult, strives to streamline their way of software development for microcontrollers by implementing this idea. Their proprietary software tool PLUS+1 GUIDE is based on the CAN bus communication network, which allows electronic control units to share data represented in the XML format. Due to compatibility problems, the application in the electronic control units requires this data to be translated into the source code in the low-level C programming language. This thesis project proposes an approach for facilitating this task by implementing a source-to-source compiler that performs the translation with a reduced level of manual user involvement. A literature review was conducted in order to find the existing solutions relevant to our project task. An analysis of the provided XML input files was thereafter performed to clarify a software design suitable for the problem. By using a general XML parser, a solution was then constructed. The implementation resulted in a fully functional source-to-source compiler, producing the generated C code within a time range of 73–85 milliseconds for the input test files of typical size. The feedback received from the domain experts at Danfoss confirms the usability of the proposed solution.

Enterobacteria have evolved several strategies to survive the acidic environment of the gastrointestinal tract. One of the acid stress resistance systems is the Cad system in Escherichia coli, which is induced by low pH and in the presence of external lysine. It consists of CadA, which catalyzes the decarboxylation of lysine to cadaverine, the lysine/cadaverine antiporter CadB and the pH sensing transcriptional regulator CadC. Moreover, the lysine permease LysP inhibits the induction of cadBA expression when lysine is absent, and the small histon-like molecule H-NS acts as repressor for both cadBA and cadC transcription. Additionally, a random mutagenesis approach revealed that a deletion in yjeK leads to highly reduced cadaverine production. YjeK acts as 2,3-lysine aminomutase (LAM) while catalyzing the isomerization of (S)-α-lysine to (R)-β-lysine. The truncated lysyl-tRNA synthetase YjeA uses (R)-β-lysine as substrate to post-translationally modify and to activate the translation elongation factor EF-P at a conserved lysine residue (K34). EF-P and its ortholog eukaryotic initiation factor 5A (eIF5A) have been investigated for more than thirty years, but their roles in translation remained enigmatic. In this work the role of active EF-P in the Cad system was investigated in more detail. Reduced cadBA expression in ΔyjeA, ΔyjeK642-1029 and Δefp mutants was linked to impaired CadC translation. As the translation of cadA and cadB was EF-P independent, a general role of EF-P in translation could be excluded. The identification of CadC as first direct target for EF-P in E. coli allowed further investigations on the role of EF-P in translation. Determining the β-galactosidase activities of CadC´-LacZ translational fusions of increasing CadC length in efp- and efp+ cells revealed that EF-P is required for translation of the sequence found between codon 108 and 158 in cadC. This region comprises a cluster of three consecutive prolines (Pro120-Pro121-Pro122). Substitution of these prolines by alanines diminished EF-P dependency. Remarkably, cells harboring the CadC-PPPIP/AAAIS variant revealed cadBA expression even under non-inducing conditions. Thus, EF-P tightly controls the CadC copy number, which is crucial for stress dependent regulation of the Cad system. In order to investigate the work mechanism of EF-P in more detail, EF-P independent CadC´-LacZ hybrids were employed to artificially introduce prolines. Three consecutive prolines were sufficient for EF-P dependency, regardless of the codon or the context. The proline-rich proteins AmiB, FlhC, Flk, NlpD, RzoR, TonB and UvrB also showed EF-P dependent expression. Thus, the recognition of three consecutive prolines by EF-P is a general mechanism and not limited to CadC. Dr. Agata Starosta of the group of Dr. Daniel Wilson (Gene Center, LMU Munich) confirmed ribosomal stalling at polyproline-stretches in samples lacking EF-P with in vitro translation assays. Finally it was investigated, if EF-P expression and modification could be stress-dependently regulated. In this work first hints are given that the efp promoter contains a repressor site, and that expression of yjeA and yjeK is dependent on the pH of the medium and the presence of the small RNA binding protein Hfq. This leads to the suggestion that small regulatory RNAs are also involved in regulation of the EF-P modification enzymes. In conclusion, the results obtained in this work reveal a new regulatory mechanism by EF-P dependent translation. 100-1000´s of polyproline rich proteins exist in bacteria, archaea and eukaryotes. Therefore, EF-P and its orthologs aIF5A and eIF5A most likely play an important role in the adjustment of copy numbers of proteins with different functions in all kingdoms of life.

With the emerging development of new technology and the constantly falling prices, more companies will find interest in industrial robots. Until today, the typical robot users have been large scale car manufacturers. But there exists a big potential market within the small to medium businesses that already uses of CNC machines. Attracting smaller businesses to start using industrial robots could open up the doors to new possibilities and increase their production. Unfortunately, most people still lack the knowledge of operating and programming industrial robots. But many companies have knowledge in G-code which is normally used in CNC machines. That is why this work is focussing on the development of a software that opens up the possibility to make use of G-code to program advanced robot paths with minimal user input. By striving for easier handling of robots, the vision about a more efficient and automated society will become one step closer. The introduction straightens out the different basic principles of CNC milling machines and robots. This will introduce the reader and highlight the different similarities and differences that exist between robots and CNC mills. The goal of this work has been to create an add-in application for ABB’s off-line programming software RobotStudio that was able to import at least one type of file format commonly used for CNC milling. The program should be able to handle some basic functionality, the focus has been on the standard iso6983 type of G-code. The project started with a literature study that gave the author a better insight in both the previous research within the area but also deeper knowledge of the systems CNC mills and robots. The work continued with the development of a software able to import the specified file format. The software has been built in C# and is built as an add-in software for ABB’s offline programming software RobotStudio. The result presents a software that is able to read different types of G-code and translate them into generated paths in RobotStudio. The software also has an inbuilt function in order to parameterize the G02 and G03 commands that represent curves in G-code into straight line segments of the type MoveL in RobotStudio.

Introdução: O Cardiff Acne Disability Index (CADI) é um instrumento originalmente desenvolvido na língua inglesa para mensurar a qualidade de vida de pacientes com acne. Considerando o impacto psicossocial desta doença, é importante dispormos de instrumentos culturalmente e linguisticamente validados para o uso em adolescentes brasileiros. Objetivo: O objetivo deste estudo é traduzir o CADI para o Português falado no Brasil (CADI-PB), adaptá-lo culturalmente e determinar sua confiabilidade e validade em pacientes adolescentes com acne. Métodos: 1) Etapa 1 – Tradução e validação cultural: O CADI foi traduzido e validado linguisticamente para o Português brasileiro (CADI-PB) de acordo com as diretrizes internacionais publicadas. 2) Etapa 2 – Validação: O CADI-PB, juntamente com os escores CDLQI (Índice de Qualidade de Vida em Dermatologia Infantil) e DLQI (Índice de Qualidade de Vida em Dermatologia) foram aplicados em paciente adolescentes (12-20 anos) portadores de acne. O Índice Global de Classificação da Acne (GAGS) foi utilizado para medir a gravidade clínica da doença. A consistência interna do CADI-PB foi avaliada pelo coeficiente alfa de Cronbach e a validade concorrente foi medida pelo coeficiente de correlação de Spearman e Teste T de Student para amostras pareadas. A validade de construto foi examinada por análise fatorial. Resultados: Um total de 100 adolescentes respondeu ao questionário. A versão CADI-PB apresentou boa confiabilidade e consistência interna (coeficiente alfa de Cronbach = 0,73). A validade concorrente da escala foi sustentada por uma correlação forte e significativa com os instrumentos CDLQI/DLQI (rs=0,802;p<0,001). A análise fatorial explanatória revelou a presença de duas dimensões subjacentes que explicam a escala. Conclusões: A versão CADI-PB é uma ferramenta confiável, válida e valiosa para mensurar o impacto da acne na qualidade de vida de pacientes adolescentes.
Background: The Cardiff Acne Disability Index (CADI) is an instrument originally developed in English language for measuring quality of life of acne patients. Considering the psychosocial impact of this disease, it is important to have instruments culturally and linguistically validated for use in Brazilian adolescents. Objective: The aim of this study was to translate the CADI into Brazilian Portuguese (CADI - PB), culturally adapt it, and verify its reliability and validity in adolescent patients with acne. Methods: 1) Step 1 - Translation and cultural validation: The CADI was translated and linguistically validated for Brazilian Portuguese (CADI - PB) in accordance with international guidelines published. 2) Step 2 - Validation: The CADI-PB, along with the CDLQI (Index of Quality of Life in Children's Dermatology) and DLQI (Index of Quality of Life in Dermatology) scores were applied to adolescents (12-20 years) patients with acne. The Global Acne Grading System (GAGS) was used to measure the clinical severity of the illness. The internal consistency of the CADI-PB was assessed by Cronbach's alpha coefficient and the concurrent validity was measure by the Spearman correlation coefficient and Student's t test for paired samples. Construct validity was assessed by factor analysis. Results: A total of 100 adolescents completed the questionnaire. The CADI-PB version showed good reliability and internal consistency (Cronbach's alpha = 0,73). The concurrent validity of the scale was supported by a strong and significant correlation with CDLQI / DLQI instruments (rs=0.802;p<0.001). Factor analysis revealed the presence of two underlying factor structure of the scale dimensions. Conclusions: CADI-PB version is a reliable, valid and valuable tool to measure the impact of acne on quality of life in adolescent patients.

[ES] El equilibrio de la homeostasis de proteínas es esencial para asegurar la funcionalidad celular. La expresión de proteínas propensas a plegarse mal induce la formación de agregados tóxicos que alteran el correcto funcionamiento de estos sistemas de control, lo que conduce a un desequilibrio de la homeostasis de proteínas, y por consiguiente a una afectación patológica. Varias enfermedades neurodegenerativas, como la enfermedad de Huntington (EH), Parkinson, Alzheimer, entre otras, tienen en común esta marca patológica molecular. Especialmente, la EH pertenece a un grupo de patologías producidas por proteínas que contienen expansiones de poliQs (varias ataxias espinocerebelosas, la atrofia muscular bulbar y espinal y la atrofia dentatorubro-pálidoluisiana), que hacen que estos péptidos sean propensos a la agregación, y causen los problemas que hemos descrito. A pesar de que estas enfermedades son genéticas, y se conoce su causa molecular, se cree que la presencia de variantes alélicas en otros genes puede exacerbar o ralentizar la agregación de proteínas con poliQs. Por tanto, la identificación de estos genes permitirá profundizar en los mecanismos moduladores de la dinámica de agregación de poliQs e identificar dianas terapéuticas frente a la toxicidad de poliQs. También es ampliamente conocido que el ARN que porta tripletes CAG tiene carácter patogénico. En este trabajo hemos desarrollado modelos, empleando C. elegans, que muestran signos indirectos de que están expresando transcritos CAG patogénicos, puesto que los tejidos diana están alterados. Usamos uno de estos modelos, que perturba la función de las neuronas GABAérgicas del gusano, para realizar un cribado de 85 compuestos farmacológicos, que nos llevó a identificar cuatro compuestos que reducían los defectos motores en estos animales. Además de poliQs y transcritos CAG, también se producen péptidos derivados de una traducción no canónica, conocida como traducción RAN. En relación a esto, hemos profundizado en la identificación y modelización de estos péptidos en C. elegans mediante la expresión de expansiones CAG fusionadas a proteínas fluorescentes para su detección in vivo. Además hemos empleado otros modelos ya existentes, para caracterizar potenciales dianas terapéuticas, como AMPK, la cual puede ser activada por diferentes sustancias. Sin embargo, algunas sustancias, como la metformina o el salicilato, son pleiotrópicas. Por tanto, hemos caracterizado la activación sinérgica de AMPK, mediante metformina y salicilato, para reducir el estrés por agregados de poliQs, con lo que podríamos evitar que otras dianas resulten activadas. Por último, hemos demostrado que este tratamiento sinérgico reduce la toxicidad inducida por la α -sinucleína implicada en la enfermedad de Parkinson. Por otro lado, hemos caracterizado en C. elegans un nuevo alelo que potencia la la agregación de poliQs, vlt10, en el gen unc-1. Nuestros resultados sugieren que la mutación unc-1(vlt10) perturba la sinapsis eléctrica entre las neuronas sensoriales IL2 y ASJ, induciendo un exceso de señalización hormonal que requiere la función de la sulfotransferasa SSU-1. También hemos demostrado que la diana de esta señal es un receptor nuclear llamado NHR-1. En este mismo capítulo, hemos identificado otra ruta de señalización hormonal, mediada por otro receptor nuclear (DAF-12), que tiene un papel protector. Se desconoce qué hormona modula la actividad de NHR-1. Sin embargo, hemos identificado que algunos de los genes regulados por NHR-1 están relacionados con el metabolismo lipídico. Además, hemos observado que la disrupción de unc-1 induce la acumulación de lípidos en los gusanos, pero a la vez estos animales contienen menos ácidos grasos totales. Esto sugiere que las grasas juegan un papel fundamental en la modulación de la agregación de poliQs, y quizás señala posibles dianas terapéuticas contra enfermedades causadas
[CA] L'equilibri de l'homeòstasi de proteïnes és essencial per a assegurar la funcionalitat cel·lular. L'expressió de proteïnes propenses a plegar-se malament indueix la formació d'agregats tòxics i altera el correcte funcionament dels sistemes de control, cosa que condueix a un desequilibri de l'homeòstasi de proteïnes, i per consegüent a una afectació patològica. Diverses malalties neurodegeneratives, com la malaltia de Huntington (MH), Parkinson i Alzheimer, entre altres, tenen en comú aquesta signatura patològica. Especialment, la MH pertany a un grup de patologies produïdes per proteïnes que contenen expansions de poliQs (s'inclouen diverses atàxies espinocerebel·loses 1, 2, 3, 6, 7 i 17, l'atròfia muscular bulbar i espinal, i l'atròfia dentatorúbrica-pàl·lidaluisiana), que fan que aquests pèptids siguen propensos a l'agregació, i causen els problemes que hem descrit. Malgrat que aquestes malalties són genètiques i es coneix la seva causa molecular, es creu que la presència de variants al·lèliques en gens pot incrementar o alentir l'agregació de proteïnes amb poliQs. Per tant, la identificació de gens modificadors permet aprofundir en els mecanismes moduladors de la dinàmica d'agregació de poliQs ens permet trobar dianes terapèutiques enfront de la toxicitat de poliQs. També és àmpliament conegut que l'ARN que contenen expansions CAG té caràcter patogènic. Per tant, hem desenvolupat models, utilitzant C. elegans, en els quals es mostren signes indirectes que expressen transcrits patogènics, ja que els teixits diana revelen una funcionalitat alterada. Utilitzant aquests models, que alteren la funció de les neurones GABAèrgiques del cuc, hem realitzat un cribratge de 85 compostos farmacològics, que ens va portar a identificar quatre compostos que reduïen els defectes motors en aquests animals. A més de poliQs i l'ARN que conté expansions de CAG, es produeixen pèptids derivats d'una traducció no canònica, coneguda com a traducció RAN. En relació amb això, hem aprofundit en la identificació i modelització d'aquests pèptids en C. elegans mitjançant l'expressió d'expansions CAG fusionades a proteïnes fluorescents per a la seva detecció in vivo. A més hem emprat models ja generats, per a caracteritzar potencials dianes terapèutiques, com AMPK puga ser activat per diversos fàrmacs. No obstant això, alguns activadors, com la metformina o el salicilat, són substàncies pleiotròpiques. Per tant, hem caracteritzat l'activació sinèrgic de AMPK, mitjançant metformina i salicilat, per a reduir l'estrés induït per agregats de poliQs i s'evita l'activació de dianes no desitjades. I finalment, hem demostrat que aquest tractament sinèrgic podria ser utilitzat per a reduir proteïnes tòxiques com la α-sinucleína, causant de la malaltia de Parkinson. D'altra banda, hem caracteritzat un nou modulador de l'agregació de poliQs, vlt10, en el gen unc-1, que produeix un augment d'agregació de poliQs. Els nostres resultats suggereixen que la mutació unc-1(vlt10) pertorba la sinapsi elèctrica entre les neurones sensorials IL2 i ASJ, induint un excés de senyalització hormonal que requereix la funció de la sulfotransferasa SSU-1. També hem demostrat que la diana d'aquest senyal és un receptor nuclear anomenat NHR-1. En el mateix capítol, hem identificat una altra ruta de senyalització hormonal, mitjançada per un altre receptor nuclear (DAF-12), que té un paper protector. Es desconeix l'hormona que modula l'activitat de NHR-1. No obstant això, hem identificat que alguns del genes regulats per NHR-1 estan relacionats amb el metabolisme lipídic. els resultats han sigut confirmats. També hem observat que la disrupció de unc-1 indueix l'acumulació de lípids en els cucs, però simultàniament aquests animals contenen menys àcids grassos totals. Això suggereix que els greixos juguen un paper fonamental en la modulació de l'agregació de poliQs, i potser assenyala
[EN] The balance of protein homeostasis is essential to ensure cellular functionality. The expression of proteins that are prone to misfolding induces the formation of toxic aggregates, which leads to an imbalance in protein homeostasis and pathological consequences. Several neurodegenerative diseases, such as Huntington disease (HD), Parkinson, Alzheimer, among others, have this molecular pathological mark in common. HD belongs to a group of pathologies produced by proteins that contain expansions of polyQs (several spinocerebellar ataxias 1, 2, 3, 6, 7 and 17, bulbar and spinal muscular atrophy and the dentatorubral-pallidoluysian atrophy), which make these peptides prone to aggregation, and cause the problems described above. Although these diseases are genetic, and their molecular cause is known, it is believed that the presence of allelic variants in other genes can exacerbate or slow the polyQ aggregation. Therefore, the identification of these genes will allow delving into the modulating mechanisms of the polyQ aggregation dynamics and find therapeutic targets against the polyQ toxicity. In addition, RNA that contains CAG triplets is pathogenic. In this work we have developed models using C. elegans that show indirect signs of pathogenic transcript expression since altered functionality was observed in target tissues. We use a model, which disturbs the function of the worm's GABAergic neurons, to screen for 85 pharmacological compounds, which led us to identify four compounds that reduced motor defects in these animals. In addition to polyQs and CAG transcripts, also are produced peptides derived from a non-canonical translation, known as RAN translation. In this regard, we have delved into the identification and modelling of these peptides in C. elegans through the expression of CAG expansions fused to fluorescent proteins to investigate them in vivo. Furthermore, we have used models previously generated to characterize potential therapeutic targets, such as AMPK. This enzyme can be activated using different compounds. However, some activators, such as metformin or salicylate, are pleiotropic substances. Therefore, in the second chapter of this thesis, we have characterised the synergistic activation of AMPK, using metformin and salicylate, to reduce the stress induced by polyQ aggregates and prevent possible unwanted targets from being activated. Finally, we have shown that this synergistic treatment could be used to reduce α-synuclein toxicity, which is involved in Parkinson disease. On the other hand, we have characterised a new allele that enhances polyQ aggregation, vlt10, in the unc-1 gene. Our results suggest that the unc-1(vlt10) mutation disturbs the electrical synapse between sensory neurons IL2 and ASJ, inducing an excess of hormonal signalling that requires the function of the sulfotransferase SSU-1. We have also shown that the target of this signal is the nuclear receptor NHR-1. In the same chapter, we have identified another hormonal signalling pathway, mediated by another nuclear receptor (DAF-12), which has a protective role. It is unknown which hormone modulates the activity of NHR-1. However, we have identified several genes that regulate lipid metabolism and whose expression could be modulated by NHR-1. In addition, we have observed that the disruption of unc-1 induces the accumulation of lipids in worms, but at the same time these animals contain less total fatty acids. Thus, our results suggest that the metabolism of fats play a key role in modulating polyQs aggregation, highlighting potential therapeutic targets against diseases caused by aggregation-prone proteins.
Gómez Escribano, AP. (2021). Modelos de toxicidad inducidos por microsatélites CAG y caracterización de dianas terapéuticas en C. elegans [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/166783
TESIS

This essay aims at analysing and understanding different choices made by Caj Lundgren when he translated Anthony Burgess’s novel A Clockwork Orange (1962), more specifically when he translated the fictive language called Nadsat, which is one of the features that made this novel famous. The method used to analyse Lundgren’s translation is based on Reiß and Veermer’s (1984/2014) concept of skopos and functional equivalence. Conclusions drawn are that Lundgren uses a compensatory translation strategy, and that a model can be created for identification of Russian words in the original text’s Nadsat and the transfer of these words to the target text as Swedish Nadsat. In a comparison between Lundgren and two Russian translators’ strategies, their strategies are shown to differ, which could be caused by different translation problems dependent on the target languages.
Denna uppsats mål är att analysera olika val som Caj Lundgren gjorde i sin översättning av Anthony Burgess roman A Clockwork Orange (1962), specifikt avseende originalets fiktiva språk, som Burgess döpte till nadsat. Metoden som använts för analysen baseras på Reiß och Veermers (1984/2014) term skopos och funktionell ekvivalens. Slutsatser som dras är dels att Lundgren använder sig av en kompensatorisk strategi vid översättning, dels att ett schema kan uppställas för identifiering av ryska ord i originalets nadsat och deras överföring till måltexten som svensk nadsat. I en jämförelse mellan Lundgrens och två ryska översättares strategier visas att deras strategier skiljer sig åt, vilket kan bero på översättningsproblematik avhängig målspråken.

Kent Fredholm (2015). Eleverna, datorn och språket: Studier av skoldatoriseringens effekter på elevers attityder, skrivstrategier och textproduktion i spanskundervisningen på gymnasiet. (The Pupils, the Computer and the Language: Studies of the Effects of School Computerisation on Pupils’ Attitudes. Writing Strategies and Written Text Production in Upper Secondary School Spanish Classes.) Stockholm University, Studies in Language Education 12. ISBN 978-91-7649-090-7. Written in Swedish, English and Spanish with abstracts in the three languages and a summary in English. The present work is based upon three studies performed between 2012 and 2014 at the Swedish upper secondary school with pupils studying Spanish as a foreign language. The first study investigates through lesson diaries and an online survey the pupils’ attitudes towards and perceptions of computer use in language learning at large, and specifically of online grammar exercises as compared to paper-based exercises. The participating pupils showed mixed attitudes towards using online exercises for grammar practice, with high demands on websites’ design and user friendliness, as well as for the correctness and reliability of automated corrections. A majority preferred mixed teaching methods (including computer use, teacher-led explanations and the use of paper- and pen-based exercises, especially translation tasks). The major advantage of using computers was considered to be for essay writing and information search. The second study investigates how a group of pupils use online resources when writing essays in Spanish, focussing on their extensive use of online translation services such as Google translate. The writing strategies of these pupils with free access to the Internet are compared to the strategies of another group working without Internet access. The third study examines effects of the use of online translation on the language in the pupils’ essays. The texts written with online translation are compared to texts written without Internet access, but with access to printed dictionaries. Few statistically significant differences can be seen between the two groups. These concern grammatical and lexical complexity and accuracy. The most clear differences regard spelling and article/noun/adjective congruence (with higher degrees of accuracy among the users of online translation), and syntax (with fewer errors in the group writing without online translation). The grammatical complexity was also somewhat higher in the online translation group. As for fluency (text length) and complexity, differences can be correlated to the pupils’ proficiency in Spanish, whereas no such correlation can be seen regarding accuracy.

Traumatic brain injury (TBI) has a dramatic impact on our society in terms of mortality, morbidity, and inherently high financial costs. Formidable research efforts are being addressed to the identification of neuroprotective agents capable of ameliorating the neurological outcome after TBI. Preclinical studies have recently demonstrated lithium to be a promising neuroprotective agent for both acute ischemic brain injury and chronic neurodegenerative disease. In light of these encouraging data, we designed a lateral fluid-percussion injury (FPI) study aimed at investigating the role of early post-traumatic administration of lithium as a strategy for reducing TBI-induced motor and cognitive deficits. The optimal dose of this agent and the time window for its administration have been determined on the basis of data derived from the assessment of motor and cognitive functioning in experimental animals, as well as from the stereological quantification of neuronal survival (PID 7) within the CA3 and hilar regions of the hippocampus ipsilateral to the FPI. In addition, we attempted to elucidate the mechanisms underlying the neuroprotective properties of this drug via western blot analysis of levels of the pro-apoptotic marker caspase-3 (PID 1, 7) and two neuroplasticity markers, growth associated protein-43 (GAP-43) and brain-derived neurotrophic factor (BDNF) (PID 1, 7, 21). Our findings indicate that low-dose lithium chloride (0.125 or 0.25 mmol/kg), given either 30 min or 8 hr after lateral FPI significantly ameliorates injury-induced cognitive and motor impairment. Specifically, cell survival in the CA3 region of the hippocampus of the injured lithium-treated animals (but not in the hilus) was significantly increased compared to injured vehicle-treated animals. Western blot analyses revealed a significant increase in GAP-43 levels on PID 7 in injured animals when treated with lithium, indicating a possible mechanism for lithium-induced neuroprotection. In contrast, BDNF levels were relatively unchanged until PID 21, and caspase-3 activation was not observed at all, suggesting that these proteins play less significant roles in the observed neuroprotective effects of lithium treatment after lateral FPI. Early administration of lithium, within 8 hours after TBI, holds promise as an effective therapy to ameliorate postinjury neurobehavioral deficits and warrants further investigation in clinical TBI studies.

碩士
大同大學
資訊工程研究所
88
The traditional CAD tools cannot effectivly support System-On-a-Chip design. We propose a web-based CAD tool for SOC design based on self-timed system technology. The CAD tool (called SOCAD) provides a graph specification tool to describe system behaviors, a translation tool to automatically translate the graph-based specification into VHDL codes and optimization schemes for better performance, less power consumption and/or less logic. This paper focuses on the algorithm of automatic translation from the graph-based specification into VHDL codes and optimization of self-timed VHDL codes. The goal of SOCAD is to facilitate SOC design to reduce design time (time-to-market) and to provide a CAD tool that can be used by anyone, in anywhere, at anytime and based on any platform.

abstract: Metal castings are selectively machined-based on dimensional control requirements. To ensure that all the finished surfaces are fully machined, each as-cast part needs to be measured and then adjusted optimally in its fixture. The topics of this thesis address two parts of this process: data translations and feature-fitting clouds of points measured on each cast part. For the first, a CAD model of the finished part is required to be communicated to the machine shop for performing various machining operations on the metal casting. The data flow must include GD&T specifications along with other special notes that may be required to communicate to the machinist. Current data exchange, among various digital applications, is limited to translation of only CAD geometry via STEP AP203. Therefore, an algorithm is developed in order to read, store and translate the data from a CAD file (for example SolidWorks, CREO) to a standard and machine readable format (ACIS format - *.sat). Second, the geometry of cast parts varies from piece to piece and hence fixture set-up parameters for each part must be adjusted individually. To predictively determine these adjustments, the datum surfaces, and to-be-machined surfaces are scanned individually and the point clouds reduced to feature fits. The scanned data are stored as separate point cloud files. The labels associated with the datum and to-be-machined (TBM) features are extracted from the *.sat file. These labels are further matched with the file name of the point cloud data to identify data for the respective features. The point cloud data and the CAD model are then used to fit the appropriate features (features at maximum material condition (MMC) for datums and features at least material condition (LMC) for TBM features) using the existing normative feature fitting (nFF) algorithm. Once the feature fitting is complete, a global datum reference frame (GDRF) is constructed based on the locating method that will be used to machine the part. The locating method is extracted from a fixture library that specifies the type of fixturing used to machine the part. All entities are transformed from its local coordinate system into the GDRF. The nominal geometry, fitted features, and the GD&T information are then stored in a neutral file format called the Constraint Tolerance Feature (CTF) Graph. The final outputs are then used to identify the locations of the critical features on each part and these are used to establish the adjustments for its setup prior to machining, in another module, not part of this thesis.
Dissertation/Thesis
Masters Thesis Mechanical Engineering 2016

碩士
國立虎尾科技大學
自動化工程研究所
99
Nowadays, steel construction projects use Computer aided engineering (CAE) facilities for designing, analyzing and fabrication of their products. But most of the time, single CAE application software is not used from the design stage to the final fabrication stage. Therefore accurate data transferring in and out of the application software plays a vital role in this case. Based on ISO 10303, German Steel Construction Association (DStV) introduced “Product Interface steel Construction” for data exchanging between different CAE application programs. According to this interface fabrication data can be exported to a neutral file which can be used for Computer Aided Manufacturing (CAM). This file includes all the manufacturing data required to fabricate steel structural members. But this neutral file should be translated or post processed according to the requirements of the machinery used for fabrication. In this research project a translator is developed to interpret the above mentioned neutral file format and generate NC part program and robot trajectory for manufacturing.

碩士
國立中央大學
中國文學系
103
The thesis tend to have a critical view on Cai ErKang's as an editor and translator identity, by introduce a new term, “New Anthologist”, and provide Shanghai Intellectuals(Yang Chang Cai Zi) a spiritual outlook during the Late Qing Dynasty and the Early Republic of China Period. Since Cai ErKang had a large influence in literary circles, newspapers and publishing, discussing Cai ErKang publisher life can help to re-examine the important role by he and his generation of Shanghai Intellectuals in the transition of Modern China. There are three discussion points will present in this thesis. First, his lifetime and experience as a press publisher. Secondly, the marketing plan of Shen Bao press and The Christian Literature Society for China. Lastly, those books compiled by Cai Erkang can divide to two part. The first part was Shen Bao press period, which contain "Gong Gui Lian Ming Pu ", "Ji Wen Lei Bian ", " Hou Qing Xin Lu " and " Xie Yu Cong Tan. Chu Ji ", and the second part was The Christian Literature Society for China period, which contain "Tai Xi Xin Shi Lan Yao ", "Zhong Dong Zhan Ji Ben Mo" and "Li Fu Xiang Li Ping Ou Mei Ji ", those content is about Sino-Japanese War of 1894-1895. From the intercourse above, this thesis try to bring out the chemistry among Cai ErKang and his publishing company, his relationship with Timothy Richard and Young John Allen, and also how his books influenced the Shanghai reader.

Often hailed as “China’s Stephen King,” Chinese psychological suspense author Cai Jun occupies a position at the peak of the new wave of young authors flooding China’s popular literature market. In order to understand Cai’s popularity as an author, the impact his works and writing have on this market, and how he creates his particular brand of suspense fiction, it is both necessary to put his works into a larger context and analyze his writing. This thesis provides a brief overview of the recent literary scene in China, from the rise of internet literature and the comeback of genre fiction to the advent of mooks, the evolution of young adult literature, and the development of the author marketing industry, and also addresses the “pure vs. popular” controversy in China’s literary world, identifies how Cai fits into these trends, and determines who Cai is as a writer in terms of genre, story content, and literary reception through the translation and analysis of Cai’s short story “Kidnapped.”