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Dissertations / Theses on the topic 'Caffeic acid phenethyl ester (CAPE)'

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Published: 4 June 2021
Last updated: 8 February 2022

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1

Roso, Nilson de Camargos [UNESP]. "Estudo da proteção renal durante a isquemia e reperfusão em ratos com o CAPE (caffeic acid phenethyl ester)." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/100142.

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Made available in DSpace on 2014-06-11T19:30:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-08-19Bitstream added on 2014-06-13T19:19:21Z : No. of bitstreams: 1 roso_nc_dr_botfm.pdf: 1975320 bytes, checksum: 9363a3fa3f08654c7f41e33f7fc538a8 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>o CAPE, ativo componente da própolis, é um potente antioxidante com importantes ações no estudo da isquemia e reperfusão renal. O objetivo deste estudo é avaliar o efeito do CAPE na lesão renal de isquemia-reperfusão em ratos anestesiados com isoflurano. Utilizou-se
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Roso, Nilson de Camargos. "Estudo da proteção renal durante a isquemia e reperfusão em ratos com o CAPE (caffeic acid phenethyl ester) /." Botucatu : [s.n.], 2011. http://hdl.handle.net/11449/100142.

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Orientador: Pedro Thadeu Galvão Vianna<br>Banca: Luiz Antonio Vane<br>Banca: João Abrão<br>Banca: Antonio Carlos Aguiar Brandão<br>Banca: Flora Margarida Barra Bisinotto<br>Resumo: o CAPE, ativo componente da própolis, é um potente antioxidante com importantes ações no estudo da isquemia e reperfusão renal. O objetivo deste estudo é avaliar o efeito do CAPE na lesão renal de isquemia-reperfusão em ratos anestesiados com isoflurano. Utilizou-se 26 ratos Wistar, machos, com peso superior a 250 g, distribuídos de modo aleatório em três grupos de animais, designados: G1 (controle, isquemia; n = 8)
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Roos, Thomas. "The polyphenols resveratrol and caffeic acid phenethyl ester: their influence on growth-related signaling pathways in vascular smooth muscle cells." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-60340.

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Roos, Thomas Ulrich. "The polyphenols resveratrol and caffeic acid phenethyl ester their influence on growth-related signaling pathways in vascular smooth muscle cells /." [S.l.] : [s.n.], 2006. http://edoc.ub.uni-muenchen.de/archive/00006034.

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Baranauskaitė, Agnė. "Kavos rūgšties fenetilo esterio poveikio inkstų mitochondrijoms tyrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2014. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20140618_215632-14448.

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Tyrimo tikslas: ištirti kavos rūgšties fenetilo esterio (CAFE) poveikį išemijos paveiktų žiurkės inkstų mitochondrijų funkcijoms. Uždaviniai: įvertinti tiesioginį in vitro CAFE poveikį inkstų mitochondrijų funkcijoms; CAFE poveikį išemijos (20 min) in vitro paveiktų inkstų mitochondrijų funkcijoms; kvėpavimo grandinės I komplekso aktyvumui; mitochondrijų gebėjimui kaupti Ca2+. Metodai. Wistar veislės žiurkių patinėliai buvo skirstomi į 4 grupes: kontrolinė grupė, 20 min trukmės išemijos, CAFE 22 mg/kg ir CAFE 34 mg/kg. CAFE buvo leidžiamas 1,5 h prieš sukeliant išemiją. Mitochondrijos buvo i
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Paracatu, Luana Chiquetto [UNESP]. "Estudo da relação entre estrutura química e atividade biológica de inibidores de NADPH Oxidase em leucócitos: relevância da oxidabilidade e hidrofobicidade." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/141533.

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Anwar, Javed. "Os efeitos do ácido cafeico e do éster fenetil do ácido cafeico sobre as atividades da acetilcolinesterase e das ecto-nucleotidases em ratos." Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/4459.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Phenolic compouds and their derivatives constitute a leading family of natural compounds. Caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) are the important members of phenolic compound, sharing several biological applications; antioxidant, neuroprotective, anti-inflammatory, antiproliferative, antibacterial, antiviral, antiatherosclerotic and anticancer properties. In spite of these, literature reportes some of its pro-oxidants activity depending on cellular environment. These pathophysiolocal properties increased the i
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Mello, Rodrigo Brito de. "Produção de biblioteca de compostos derivados de produtos naturais: síntese e estudo de atividades biológicas." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-17042015-151409/.

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O presente trabalho trata da semissíntese de análogos de importantes compostos líderes (afidicolina, lausona, lapachol e CAPE) utilizando técnicas de química medicinal como bioisosterismo, adição de grupamento funcional e simplificação molecular. Dessa forma foi possível obter uma biblioteca de análogos racionais, visando a manipulação de parâmetros físico-químicos e estruturais, para fins de bioprospecção. Foram desenvolvidos derivados de afidicolina mais lipofílicos, por meio da acilação das hidroxilas presentes na estrutura química deste terpeno. Tentativas de formação de bioisósteros, sais
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Humphrey, Peter Saah. "Signal transduction mechanisms for stem cell differentation into cardiomyocytes." Thesis, University of Hertfordshire, 2009. http://hdl.handle.net/2299/3760.

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Cardiovascular diseases are among the leading causes of death worldwide and particularly in the developed World. The search for new therapeutic approaches for improving the functions of the damaged heart is therefore a critical endeavour. Myocardial infarction, which can lead to heart failure, is associated with irreversible loss of functional cardiomyocytes. The loss of cardiomyocytes poses a major difficulty for treating the damaged heart since terminally differentiated cardiomyocytes have very limited regeneration potential. Currently, the only effective treatment for severe heart failure i
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Souza, Flávia Castro Ribas de. "Efeitos dos inibidores de NF Kappa-B e Rho Quinase em um modelo de asma animal: comparação com o tratamento com corticosteroides." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5165/tde-28032018-093526/.

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Embora a grande maioria dos pacientes com asma tenha controle com o padrão de tratamento com corticosteroides, 5 a 10% destes asmáticos ainda desenvolvem algumas formas graves da doença e são considerados pacientes difíceis de controlar. A ativação do NFkB contribui para a manutenção e desenvolvimento de inflamação pulmonar crônica na fisiopatologia da asma. O éster fenetilico do ácido cafeico (CAPE), um componente ativo de própolis das colmeias de abelhas, é conhecido por ter propriedades antiinflamatórias e imunomoduladoras. É conhecido como um potente e um inibidor específico da ativação de
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Chen, Kang Chian, and 陳鏗鏘. "Cell-Immunity of CAPE (Caffeic Acid Phenethyl Ester)-like analogues." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/13611531540238708440.

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碩士<br>中山醫學院<br>口腔醫學研究所<br>88<br>The purpose of this experiment is to study the cell toxicity and the effect of PBMC excreted cytokines by the CAPE-like analogues, 3-(3,4-dihydroxy -phenyl) acrylic acid ethyl ester (EC), 3-(4-bromophenyl) acrylic acid phenethyl ester (BrCAPE). In this study, experiment was divided into two parts. (1) Incubated PBMC in the analogues for 24 and 48 hours. Using MTT (microculture tetrazolium assay) to analyze the cell activity. (2) Incubated PBMC in the analogues for 24 and 48 hours. Analyzing the change of the four cytokines, IL-4, IL-6, Human GM-CSF and Human Sol
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TASI, CHIA-FANG, and 蔡佳芳. "Total synthesis of CAPE (caffeic acid phenethyl ester) -like analogues and study on their biological activity." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/48715015279602065090.

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碩士<br>中山醫學院<br>毒理學研究所<br>87<br>Propolis, a honey bee hive product, exhibits a broad spectrum of medical application including antibiotic, antiviral, anti-inflammatory and tumor growth inhibition; some of the observed biological effects may be due to caffeic acid (cinnamic acid) esters that are present in propolis. In the present work we synthesized five caffeic acid esters, namely 3-(3,4-dihydroxyphenyl)acrylic acid phenethyl ester (CAPE), 3-(3,4-dimethoxyphenyl)acrylic acid phenethyl ester (PEDMC), 3-(3,4-dihydroxyphenyl)acrylic methyl ester (MC), 3-(3,4-dihydroxyphenyl) acrylic acid ethyl es
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Ketkar, S. S., Sudhir K. Pagire, N. R. Goud, K. R. Mahadik, A. Nangia, and Anant R. Paradkar. "Tracing the architecture of caffeic acid phenethyl ester cocrystals: studies on crystal structure, solubility, and bioavailability implications." 2016. http://hdl.handle.net/10454/8911.

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Yes<br>Caffeic acid phenethyl ester (CAPE) is a polyphenolic active compound present in popular apiproduct, ‘propolis’ obtained from beehives. Though it has broad therapeutic capability, the bioavailability of CAPE is limited due to poor solubility. In this study, we report novel cocrystals of CAPE engineered using coformers such as caffeine (CAF), isonicotinamide (INIC), nicotinamide (NIC) with enhanced solubility and bioavailability of CAPE. The cocrystals were prepared by microwave-assisted cocrystallization and characterized using PXRD, DSC and Raman spectroscopy. PXRD and DSC confirm the
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Hsieh, Chia-Hsins, and 謝佳欣. "The Effect of Caffeic Acid Phenethyl Ester (CAPE) on Thioacetamide-Induced Liver Injury : In Vitro and In Vivo Studies." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/63603549899467726611.

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碩士<br>國立陽明大學<br>解剖暨細胞生物學研究所<br>96<br>In general, liver fibrosis can be regarded as a chronic wound healing process, characterized by increased deposition of connective tissue. Proliferation and activation of hepatic stellate cells (HSCs) are critical steps in the development of liver fibrosis. Previous studies have shown that excess oxidative stress causes activation of HSCs. During this process, transforming growth factor-b1 (TGF-b1) is known to be the most potent factor to induce HSCs activation and accumulation of exrtacellular matrix (ECM). Therefore, decrease of oxidative stress and suppr
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Wang, Xinyu 1974 Aug 12. "Amelioration of oxidative stress in human endothelial cells by caffeic acid phenethyl ester (CAPE) and fluorinated derivatives (FCAPES) and pharmacokinetic characterization of CAPE and FCAPE in rats." Thesis, 2007. http://hdl.handle.net/2152/3716.

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Tissue ischemia is a major cause of morbidity contributing to disease processes such as cardiovascular diseases, stroke, cancer, and traumatic injury and may lead to death. Failure to quickly reestablish flow to ischemic tissue results in tissue death. However, even timely return to normal flow has a downside in that the reintroduction of oxygen to ischemic tissue results in ischemia/reperfusion (I/R) injury that produces an oxidant stress. This pathological process requires new therapeutic strategies and agents to reduce the personal, social and economic loss. One of the most generally accept
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Huang, Cheng-ju, and 黃靜如. "The Modulatory Effect of Caffeic Acid Phenethyl Ester (CAPE) on a Human Non-Small Cell Lung Cancer Cell Line parental H460 and It’s Paclitaxel Resistant Mutant." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/34829311650708971056.

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碩士<br>國立清華大學<br>生命科學系<br>90<br>Acquired resistance to chemotherapy of anticancer drug paclitaxel is the problem during cancer treatment. To investigate the drug resistance, we established a paclitaxel-resistant mutant cell line called H460/TAX cells derived from human non-small cell lung cancer parental H460 cells. Nuclear factor kB (NF-kB) activation is associated with inducible chemoresistance. Many anti-cancer drugs are able to activate NF-kB. Paclitaxel is also one of anti-neoplastic drugs that activate NF-kB. Inhibition of NF-kB could sensitize cell to chemotherapy-induced apoptosis. Here
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Yeh, Chih-Hao, and 葉志豪. "Enzymatic Synthesis of Caffeic Acid Phenethyl Ester." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/73px69.

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碩士<br>國立臺灣科技大學<br>化學工程系<br>94<br>Enzymatic synthesis of caffeic acid phenethyl ester from caffeic acid and 2-phenylethanol has been successfully carried out using Novozym 435 as the catalyst. Although the solubility of caffeic acid was low in non-polar solvents, they were found to give better conversions than in polar solvents. Isooctane gave the highest conversion and was chosen as the solvent in this study. A temperature of 70oC was proven as the optimum reaction temperature. This was attributed to the increase in enzyme activity and solubility of reactants. At a fixed caffeic amount of 2 mg
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Shen, Chia-Hung, and 沈家弘. "Mechanisms Involved in the Antiplatelet Activity of Caffeic acid phenethyl ester." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/19752025376233584265.

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碩士<br>臺北醫學大學<br>醫學研究所<br>93<br>Caffeic acid phenethyl ester (CAPE) is an active component of propolis, which is a resinous hive product collected by honeybees from various plant sources. It has been shown to exhibit anticancer, anti-inflammatory and immunomodulatory activities in a broad spectrum of systems. However, the pharmacological affects of CAPE on platelet function are not yet understood, we are interested in investigating the inhibitory effects of CAPE on cellular signal transduction during the process of platelet activation. In this study, CAPE concentration-dependently (6-25 M) inh
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Lu, Jheng-Kun, and 盧政昆. "Caffeic Acid Phenethyl Ester as A Neuroinflammatiory Inhibitor in Microglial Cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/wv89em.

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碩士<br>亞洲大學<br>生物科技學系<br>102<br>英文摘要 Microglial activation has been widely demonstrated to mediate inflammatory processes that are crucial in several neurodegenerative disorders. Pharmaceuticals that can deliver direct inhibitory effect on microglia is therefore considered as a potential strategy to counterbalance neurodegenerative progression. Caffeic acid phenethyl ester, a natural phenols in honeybee propolis, is known to possess antioxidant, and anti-inflammatory properties. Accordingly, the current study intended to probe the effects of CAPE on microglia activation by using in vitro and in
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Hsing-Chun and 郭星君. "Studies on the antitumor effects and mechanisms of caffeic acid phenethyl ester." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/25803942261345889946.

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博士<br>中山醫學大學<br>生化暨生物科技研究所<br>94<br>Part-1 The mechanistic study of caffeic acid phenethyl ester induced C6 glioma growth inhibition and differentiation in vitro and in vivo Caffeic acid phenethyl ester (CAPE), a component of honeybee propolis, has been reported to hold various biochemical responses. More recently, work on the anti-inflammatory, anti-bacteria, anti-fungus, anti-virus and anti-tumor activity of propolis has concentrated on caffeic acid phenethyl ester（CAPE）, which is one of components. As our previous studies, we had found CAPE induced apoptosis of C6 glioma cells and was media
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Chen, Hsiao-Ching, and 陳曉菁. "Studies on the Optimization of Ultrasound-Aided Enzymatic Synthesis of Caffeic Acid Phenethyl Ester." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/61902992579577576676.

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博士<br>大葉大學<br>生物產業科技學系<br>98<br>Phenolic acids are good radical scavengers for anti-inflammatory and anti-oxidant performances. Caffeic acid, one kind of phenolic acid, increase the solubility in oil-based formulas and emulsions is to esterify the compounds with alcohols and enhance anti-oxidant ability in the food and cosmetics applications. However, the reagents used in chemical synthesis of caffeic acid phenethyl ester (CAPE) are harmful to natural environmental. In contrast, enzymatic synthesis offers the advantages of specificity, milder reaction conditions, and minimization of side react
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Yu, Szu-Hsu, and 余偲旭. "Activation of AMPK protects C6 glioma cells from caffeic acid phenethyl ester-induced apoptosis." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/69762645297603583438.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>97<br>Caffeic acid phenethyl ester (CAPE), an active component of propolis, has many biological and pharmacological activities including antioxidant, anti-inflammation, and anticancer effect. Previous studies have shown that CAPE exhibit significant cytotoxicity in various malignant cell lines. AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis, and AMPK regulates a variety of cell functions including proliferation, apoptosis, and brain metabolic plasticity. C6 glioma cells displayed preferential cytotoxicity to CAPE among the four tested ce
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Hsu, Hsien-Jung, and 許憲蓉. "Study on the Action Mechanism of the Caffeic Acid Phenethyl Ester in Human Cancer." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/75001379432333631850.

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碩士<br>國防醫學院<br>生物化學研究所<br>92<br>Proplis, a honeybee-hive products, exhibits anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Known for the variety of its beneficial effects, it has been a popular folk medicine through the ages. The active ingredient of propolis was identified as caffeic acid phenylether ester ( CAPE). CAPE was shown to involved in many cellular processes to induce differential toxicity to cancer cells versus normal cell lines. Despite the knows properties of these compounds in modulation of cellular processes, the molecular basis of their action re
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Peng, Chih-Yu, and 彭芷瑜. "Inhibitory effects of Caffeic Acid Phenethyl Ester on Oral Cancer Cell Metastasis and Invasion." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/67560931312414073588.

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博士<br>中山醫學大學<br>牙醫學系碩士班<br>101<br>Caffeic acid phenethyl ester (CAPE), an active component extracted from honeybee hives, exhibits anti-inflammatory and anticancer activities. However, the molecular mechanism by which CAPE affects oral cancer cell metastasis has yet to be elucidated. In this study, we investigated the potential mechanisms underlying the effects of CAPE on the invasive ability of SCC-9 oral cancer cells. Results showed that CAPE attenuated SCC-9 cell migration and invasion at noncytotoxic concentrations (0 μM to 40μM). Western blot and gelatin zymography analysis findings furth
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Hung, Hsin-Tien, and 洪心恬. "Fluorinated Caffeic Acid Phenethyl Ester Derivatives Against Hydrogen Peroxide-induced Oxidative Stress in Drosophila Model." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/87085706336495833321.

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碩士<br>國立陽明大學<br>藥理學研究所<br>96<br>Oxidative stress to organism over its lifespan can cause premature aging and disease including cancer, atherosclerosis and neurodegenerative disorders, etc. Caffeic acid phenethyl ester (CAPE) is a polyphenolic plant product of honeybee propolis. There is abundant evidence that CAPE has powerful properties include anti-tumor, anti-HIV, immunomodulatory, anti-inflammatory, antioxidant effect and apoptosis. It indicates that the antioxidative activity of CAPE depends not only on the number of hydroxyl groups or catechol moieties but also on its solubility and stab
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Chen, Yu-Jen, and 陳裕仁. "Studies on Apoptosis Induction and Radiation Sensitization in Tumor Cells by Caffeic Acid Phenethyl Ester." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/47264919829207396796.

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博士<br>國立陽明大學<br>傳統醫藥學研究所<br>90<br>Caffeic acid phenethyl ester (CAPE), an active component of propolis, has many biological activities and pharmacological functions including anti-oxidation and tumor cell cytotoxicity. In this study, the type of cell death in human leukemic HL-60 cells after CAPE treatment and the relationship between CAPE-induced redox change and cell apoptosis have been elucidated. The mechanism of CAPE-induced radiosensitization in tumor cells and tumor-bearing animals were also studied. CAPE entered into HL-60 cells very rapidly and reduced cell viability in a concentratio
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Yang, John. "Pharmacokinetics and cytoprotective evaluation of Caffeic Acid Phenethyl Amide and fluorinated derivatives against oxidative stress." 2012. http://hdl.handle.net/2152/19620.

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Ischemic injury occurs when the flow of blood is reduced or blocked to an area of the body and can cause significant tissue damage by generation of reactive oxygen species (ROS), activation of apoptotic pathways and through induction of the inflammatory response. Restoration of blood flow and reperfusion of the blocked site, while essential, can generate a second injury that itself needs to be controlled. Together the two injuries are termed ischemia/reperfusion (I/R) injury. This type of injury is frequently encountered in medicine and is a major medical problem. Therapeutic strategies to com
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Ai-Chun, Huang, and 黃艾君. "Effects of Caffeic Acid Phenethyl Ester from Propolis on Tolerance of Human Leukocytes Exposured to Hyperthermia." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/27081576041925996388.

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碩士<br>中國文化大學<br>運動教練研究所<br>89<br>The purpose of this research is to determine the effect of propolis on the tolerance of human leukocytes exposed to hyperthermia. The Subjects were separated into two groups. The first group was well-trained competitive cyclists (n=3, male, 20.00±0.00 years, 175.67±3.48 cm, 69.00±0.58 kg) who had trained more than 3 years; the second group was sedentary controls (n=3, male, 20.67±0.33 years, 176.00±1.73 cm, 64.67±3.33 kg) with no special training experience. We isolated peripheral blood mononuclear cells (MNC) from the subjects, and treated MNC with various dos
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Chiau-Juno, Chiu, and 邱巧絨. "The Immunoregulatory Effect of Caffeic Acid Phenethyl Ester on Peripheral Blood Mononuclear Cells from Asthmatic Children." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/45050244971969070424.

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碩士<br>輔仁大學<br>食品營養學系<br>93<br>Asthma is characterized as chronic airway inflammation disease. TH2 cells (type 2 T helper cells) are crucial for the initiation and progression of asthma. Current treatments for asthma are mainly based on pharmacological interventions, such as treatment with glucocorticoids. Although these treatments are effective for controlling disease, many patients must take these drugs for life and concerns about side-effects. Previous study revealed that eosinophilia in bronchoalveolar lavage fluid and secretion of the pro-inflammatory cytokines, such as IL-6 (interleukin-6
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Wang, Li-Chieh, and 王麗潔. "The Regulatory Effect and Mechanism of Caffeic Acid Phenethyl Ester on Human Dendritic Cells and T Cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/94690430481060285568.

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博士<br>臺灣大學<br>臨床醫學研究所<br>98<br>Asthma is the leading chronic disease in children. The mortality and morbidity of asthma has been decreased recently due to the advance of management of asthma. The treatment of asthma includes inhaled corticosteroid (the main drug), theophylline, long-acting beta2-agnoist, leukotriene antagonist and anti-IgE, etc. However, some severe difficult to treat patients still not achieve controlled under these treatments. We therefore intend to evaluate other potential treatments and their mechanism. Propolis, an ancient herbal medicine, has been reported the beneficial
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Hou, Shin-Miao, and 侯欣妙. "Study the Mechanisms of Caffeic Acid Phenethyl Ester on Modulating OVA-Sensitized Murine Model of Airway Inflammation." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/35009201290730015320.

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碩士<br>輔仁大學<br>食品營養學系<br>93<br>The dietary pattern and environmental status has changed, which in term causing an increasing rate of allergic disease such as asthma. Previous study showed that the ovalbumin (OVA)-sensitized mice fed with propolis shown lower air hyperresponsiveness, and the Interferon- (IFN-) secreted from splenocytes of propolis-fed groups was higher and interleukin-10 (IL-10) was lower than control group. According to this, we proposed that propolis has beneficial effects on asthma. The aim of the study will focus on finding the mechanisms of the compounds in propolis on OV
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Kuo, Hsing Chun, and 郭星君. "The mechanistic study of caffeic acid phenethyl ester induced apoptosis and growth arrest in C6-glioma cells." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/25924435924143125737.

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碩士<br>中山醫學大學<br>生物化學研究所<br>90<br>Abstract More recently, work on the anti-inflammatory, anti-bacteria, anti-fungus, anti-virus and anti-tumor activity of propolis has concentrated on caffeic acid phenethyl ester（CAPE） which is one of components. As our previous studies, we had found CAPE and ethyl caffeicate (EC) exhibited significant cytotoxicity on oral cancer cells. Herein we further investigated CA（caffeic acid）, EC, and CAPE by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay on the growth of H3B hepatocytes and C6 glioma cells. CAPE showed significant cy
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Tseng, Wen-Ser, and 曾文瑟. "Anti-proliferation and radio-sensitizing effect of caffeic acid phenethyl ester on human Daoy medulloblastoma cell line." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/01080141749648728526.

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碩士<br>國立陽明大學<br>傳統醫藥學研究所<br>92<br>Abstract Medulloblastoma (MB) is the most common malignant cere- bellum tumor in children. Despite surgical eradication, chemotherapy and radiotherapy, the prognosis of MB is poor. To improve current treatment prognosis in MB patients, the discovery of novel therapeutic agents become a urgent issue. Caffeic acid phenethyl ester (CAPE), an active component of propolis, is known to have antioxidant, anti-inflammatory, antiviral, reperfusion injury prevent, anticancer and radio-sensitizing effects. This study is aimed to investigate the effect of anti-prolife
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Fu, Yu-Ke, and 傅榆格. "Suppressive effect of Caffeic Acid Phenethyl Ester on proliferation and survival of docetaxel-resistant prostate cancer cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/t294qm.

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Lin, Hua-Jin, and 林華經. "Interaction of Antioxidants Probucol and Caffeic Acid Phenethyl Ester with Phosphatidylcholine Liposomes and Human Low Density Lipoprotein." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/55930846562690784905.

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Chen, Ming-Jen, and 陳銘仁. "The Effect of Caffeic Acid Phenethyl Ester on Inducing Apoptosis of Human Pancreatic Cancer Cells and Related Mechanisms." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/66440146428591628229.

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碩士<br>臺北醫學大學<br>醫學研究所<br>94<br>Pancreatic cancer is the fourth leading cause of cancer death in the western countries and the tenth in Taiwan. There are more than 85% of pancreatic cancers metastasized or extended locally at the time of diagnosis. Finally there were about less than 10% of the pancreatic cancer patients able to undergo curative resection. The average survival duration for the patients with pancreatic cancer is about 4–6 months, and the overall 5-year survival rate is less than 5%. An effective treatment or novel agent for this devastating disease is urgently needed. Caffeic aci
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Shin-yun, Yu, and 余欣芸. "Investigation of the inhibitory mechanisms of Carprofen and Caffeic acid phenethyl ester on LPS-induced Monocytic cells Activation." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/09110451291950738138.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>98<br>Human immune system plays an important role in the pathogenesis of sepsis. In human innate immune system, monocytes are the key element and served as a critical role of defense. Inflammatory monocytes secret cytokine and express chemokine receptor in response to microbial and attract immune cell to the inflammatory site. Lipopolysaccharide (LPS) is main componment of cell wall in Gram-negative bacteria.Under the stimulation of LPS, monocytes will help LPS binds to Toll-like receptor (TLR) by CD14 on their cell membrane. And then innate immunity activation, mono
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Hwang, Shu-Lin, and 黃淑琳. "Studies on cell growth arrest and anti-inflammatory effects of caffeic acid phenethyl ester and a fermented legume mixture." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/21237848529918508960.

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碩士<br>國立中興大學<br>分子生物學研究所<br>99<br>Caffeic Acid Phenethyl Ester (CAPE) is found in resinous mixture used by honey bees, commonly called propolis and the CAPE has been shown to have antioxidant, anti-inflammatory, anti-viral and is cytotoxic to cancer cells. The effect of CAPE to kill many strains of cancer cells is studied. It has been found out through experiments that the concentration of 0-20 μg/mL of CAPE to the HL-60, HepG2, C3A, CL1-0, H460, Caco2, MCF-7, PA-1 cancer cell lines showed decreased cell survival after 48 hrs. The Inhibition concentration (IC50) was &amp;lt;2 µg/ml or 4 – 16 µ
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Yung-NingYang and 楊詠甯. "Synergistic inhibition of glioma cell growth by interleukin-33 gene knockdown in combination with diethyldithiocarbamate or caffeic acid phenethyl ester." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/hzkkt8.

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Liang, Chin-Yun, and 梁璟云. "Immunomodulatory Effects of Caffeic Acid Phenethyl Ester on Lung and Spleen Function in Murine Asthma in vivo or ex vivo." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/89805317694813301607.

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碩士<br>輔仁大學<br>營養科學系<br>95<br>Asthma is a chronic airway inflammation disease caused by the TH1/ TH2 cytokines secretion imbalance. One of the mechanisms is IL-5 secreted by TH2 cells activating eosinophils infiltration to airway inflammation site, and to release more pro-inflammatory mediators aggravating symptoms. In clinical, steroids are often used to improve inflammation, but long term or improper dependence on drugs would follow some complications. Previous study shown OVA (ovalbumin)-immunized airway inflammatory mice model fed with 5, 10 or 20 mg/kg BW caffeic acid phenethyl ester (CAPE
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Hsiao, Ping-Hsuan, and 蕭稟璇. "Using Caffeic Acid Phenethyl Ester as a Therapeutic Agent for Suppression of Castration-Resistent LNCaP 104-R1 Prostate Cancer Cell Line." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/36542883462856928455.

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碩士<br>國立清華大學<br>生物科技研究所<br>102<br>Caffeic acid phenethyl ester (CAPE) is a bioactive component derived from honeybee hive propolis. We previously showed that treatment with CAPE suppresses growth of androgen-dependent AR-positive LNCaP 104-S cells both in vitro and in vivo via inhibition of Akt and c-Myc signaling, thus causes G1 cell cycle arrest. Androgen ablation therapy is the primary treatment for metastatic prostate cancer (PCa). However, a majority of PCa patients receiving the androgen ablation therapy will ultimately develop recurrent castration-resistant prostate cancer (CRPC) within
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Roos, Thomas Ulrich [Verfasser]. "The polyphenols resveratrol and caffeic acid phenethyl ester : their influence on growth-related signaling pathways in vascular smooth muscle cells / Thomas Ulrich Roos." 2006. http://d-nb.info/982303947/34.

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Chen, Kuan-Jung, and 陳冠蓉. "Investigation of the inhibitory mechanisms of Caffeic acid phenethyl ester and Dynasore on microglial activation and their protective effects on neuroinflammation in vivo." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/93591514214620099054.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>98<br>Glial activation plays an important role in the pathogenesis of neuroinflammatory and neurodegenerative diseases. Activated glial cells can secrete various proinflammatory cytokines and neurotoxic mediators, which may contribute to neuronal cell death. Inhibition of glial activation may alleviate neurodegeneration under these conditions. In LPS-induced microglial activation, it was shown that CAPE and Dynasore both attenuated the expression of iNOS protein. Moreover, CAPE and Dynasore inhibited IκBα degradation, and then could affect the nuclear translocati
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Chiu, Hui-Wen, and 邱惠雯. "1. The Antioxidant Effect of Caffeic Acid Phenethyl Ester on Human Neutrophils 2.The Proteomics Research on Neutrophil, Platelet and Vascular Smooth Muscle Cell." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/94276412368949891215.

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碩士<br>長庚大學<br>天然藥物研究所<br>92<br>1.The neutrophil is body’s first line of defense against microorganisms and a critical effector cell in both innate and humoral immunity. However, the capacity for bacterial killing carriers with it an implicity for host tissue destruction, as observed in inflammatory and autoimmune disease. Neutrophils produce potentially dangerous metabolites from superoxide in the defense against microorganisms. Alternatively, caffeic acid phenethyl ester (CAPE) was isolated from propolis that has many biological and pharmacological activities including anti-oxidation and anti
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Tseng, Jen-Chih, and 曾仁志. "Using Micro-Western Array and gene array to systematically analyze the molecular mechanisms of anti-metastasis effects of caffeic acid phenethyl ester on prostate cancer." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/m9m7cw.

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