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Journal articles on the topic 'Caffeic acid phenethyl ester (CAPE)'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Petelinc, Tanja, Manca Medved, Tomaž Polak, and Polona Jamnik. "Caffeic Acid Esters Affect Intracellular Oxidation and Vitality of Yeast Saccharomyces cerevisiae Cells." Natural Product Communications 12, no. 11 (2017): 1934578X1701201. http://dx.doi.org/10.1177/1934578x1701201131.

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The effect of four esters of caffeic acid, caffeic acid methanol ester (CAME), caffeic acid ethanol ester (CAEE), caffeic acid isopropyl ester (CAIPE) and caffeic acid phenethyl ester (CAPE) on intracellular oxidation, vitality and viability of the yeast Saccharomyces cerevisiae as a model eukaryotic organism was investigated. Results showed that each ester showed its own behavior at the concentrations tested. For CAPE, CAIPE and CAEE decreased intracellular oxidation and simultaneously increased cellular vitality with no changes in cellular viability compared to the control were determined. A

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2

Kassim, Mustafa, Marzida Mansor, Tengku Ain Kamalden, et al. "Caffeic Acid Phenethyl Ester (CAPE)." Shock 42, no. 2 (2014): 154–60. http://dx.doi.org/10.1097/shk.0000000000000179.

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Kong, Lingjie, Yuhao Zhang, Zhouxu Feng, Jie Dong, and Hongcheng Zhang. "Phenolic Compounds of Propolis Alleviate Lipid Metabolism Disorder." Evidence-Based Complementary and Alternative Medicine 2021 (February 20, 2021): 1–16. http://dx.doi.org/10.1155/2021/7615830.

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Lipid metabolism disorder is one of the significant risk factors for a multitude of human diseases and has become a serious threat to human health. The present study aimed to evaluate the effects of phenolics from poplar-type propolis on regulating lipid metabolism by using cell models of steatosis induced by palmitic acid (PA). Our study shows that phenolic esters have higher lipid-lowering activities than phenolic acids, especially for three caffeic acid esters, including caffeic acid phenethyl ester (CAPE), caffeic acid cinnamyl ester (CACE), and caffeic acid benzyl ester (CABE). Most notab

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Collins, William, Noah Lowen, and David J. Blake. "Caffeic Acid Esters Are Effective Bactericidal Compounds Against Paenibacillus larvae by Altering Intracellular Oxidant and Antioxidant Levels." Biomolecules 9, no. 8 (2019): 312. http://dx.doi.org/10.3390/biom9080312.

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American Foulbrood (AFB) is a deadly bacterial disease affecting pupal and larval honey bees. AFB is caused by the endospore-forming bacterium Paenibacillus larvae (PL). Propolis, which contains a variety of organic compounds, is a product of bee foraging and is a resinous substance derived from botanical substances found primarily in trees. Several compounds from the class of caffeic acid esters, which are commonly found in propolis, have been shown to have antibacterial activity against PL. In this study, six different caffeic acid esters were synthesized, purified, spectroscopically analyze

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Murtaza, Ghulam, Sabiha Karim, Muhammad Rouf Akram, et al. "Caffeic Acid Phenethyl Ester and Therapeutic Potentials." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/145342.

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Caffeic acid phenethyl ester (CAPE) is a bioactive compound of propolis extract. The literature search elaborates that CAPE possesses antimicrobial, antioxidant, anti-inflammatory, and cytotoxic properties. The principal objective of this review article is to sum up and critically assess the existing data about therapeutic effects of CAPE in different disorders. The findings elaborate that CAPE is a versatile therapeutically active polyphenol and an effective adjuvant of chemotherapy for enhancing therapeutic efficacy and diminishing chemotherapy-induced toxicities.

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Olgierd, Batoryna, Żyła Kamila, Banyś Anna, and Morawiec Emilia. "The Pluripotent Activities of Caffeic Acid Phenethyl Ester." Molecules 26, no. 5 (2021): 1335. http://dx.doi.org/10.3390/molecules26051335.

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Caffeic acid phenethyl ester (CAPE) is a strong antioxidant extracted from honey bee-hive propolis. The mentioned compound, a well-known NF-κB inhibitor, has been used in traditional medicine as a potent anti-inflammatory agent. CAPE has a broad spectrum of biological properties including anti-viral, anti-bacterial, anti-cancer, immunomodulatory, and wound-healing activities. This review characterizes published data about CAPE biological properties and potential therapeutic applications, that can be used in various diseases.

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Pittalà, Valeria, Loredana Salerno, Giuseppe Romeo, Rosaria Acquaviva, Claudia Di Giacomo, and Valeria Sorrenti. "Therapeutic Potential of Caffeic Acid Phenethyl Ester (CAPE) in Diabetes." Current Medicinal Chemistry 25, no. 37 (2019): 4827–36. http://dx.doi.org/10.2174/0929867324666161118120908.

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Diabetes mellitus is a complex metabolic disease characterized by high blood sugar levels. Different pathogenic processes are involved in the etiology of the disease. Indeed, chronic diabetes hyperglycemia is often associated with severe long-term complications including cardiovascular symptoms, retinopathy, nephropathy, and neuropathy. Although the precise molecular mechanisms underlying diabetes are not yet clear, it is widely accepted that increased levels of oxidative stress are involved in the onset, development and progression of diabetes and its related complications. In this regard, th

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8

Tekin, Ahmet, Serdar Türkyılmaz, Tevfik Küçükkartallar, et al. "Effects of Caffeic Acid Phenethyl Ester (CAPE) on Hepatopulmonary Syndrome." Inflammation 34, no. 6 (2010): 614–19. http://dx.doi.org/10.1007/s10753-010-9270-8.

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9

Ağrı, İbrahim, Arzu Erdal Ağrı, Mehmet Eser Sancaktar, et al. "The effect of caffeic acid phenethyl ester (CAPE) on tympanosclerosis." International Journal of Pediatric Otorhinolaryngology 95 (April 2017): 127–32. http://dx.doi.org/10.1016/j.ijporl.2017.02.020.

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10

Anjaly, Km, and Ashu B. Tiku. "Radio-Modulatory Potential of Caffeic Acid Phenethyl Ester: A Therapeutic Perspective." Anti-Cancer Agents in Medicinal Chemistry 18, no. 4 (2018): 468–75. http://dx.doi.org/10.2174/1871520617666171113143945.

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Background: Use of natural agents is an upcoming area of research in cancer biology. Caffeic acid phenethyl ester (CAPE) has received great attention because of its therapeutic potential in various conditions including cancer. It is an active/abundant component of propolis, a honey bee hive product produced by bees using their enzyme-rich digestive secretions on resinous mix, bee wax and pollen from plants. It is used to protect the beehive against bacteria and other infections. Therefore a literature survey was done to understand the therapeutic potential of this compound. Although a lot of w

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11

Yordanov, Yordan. "Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application." Pharmacia 66, no. 3 (2019): 107–14. http://dx.doi.org/10.3897/pharmacia.66.e38573.

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Caffeic acid phenethyl ester (CAPE) is the major pharmacologically-active component of some propolis types, rich in polyphenols, such as poplar propolis types. CAPE has the potential to be applied as a pharmaceutical as it possesses most of the pharmacological activities of propolis, such as anti-proliferative, antioxidant, immunomodulatory, antidiabetic, anti-inflammatory and antimicrobial. Its advantage is that it lacks some of the downsides of total propolis extracts, such as inability for unified standardization, which is cornerstone for implementing its therapeutic potential as a drug. Th

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Zhao, Yuhao, Xiaokun Pang, Akriti Nepal, et al. "Caffeic Acid Phenethyl Ester Effects: In Silico Study of its Osteoimmunological Mechanisms." Letters in Drug Design & Discovery 17, no. 5 (2020): 556–62. http://dx.doi.org/10.2174/1570180815666180803111902.

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Background: Biological system complexity impedes the drug target identification by biological experiments. Thus drugs, rather than acting on target site only, can interact with the entire biological system. Study of this phenomenon, known as network pharmacology, provides grounds for biological target identification of new drugs or acts as a foundation for the discovery of new targets of present drugs. No publication is available on the interaction network of CAPE. Aim: This study was aimed at the investigation of the candidate targets and possible interactions of caffeic acid phenethyl ester

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13

Vanella, Luca, Daniele Tibullo, Justyna Godos, et al. "Caffeic Acid Phenethyl Ester Regulates PPAR’s Levels in Stem Cells-Derived Adipocytes." PPAR Research 2016 (2016): 1–13. http://dx.doi.org/10.1155/2016/7359521.

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Hypertrophic obesity inhibits activation of peroxisome proliferators-activated receptor gamma (PPARγ), considered the key mediator of the fully differentiated and insulin sensitive adipocyte phenotype. We examined the effects of Caffeic Acid Phenethyl Ester (Cape), isolated from propolis, a honeybee hive product, on Adipose Stem Cells (ASCs) differentiation to the adipocyte lineage. Finally we tested the effects of Cape on insulin-resistant adipocytes. Quantification of Oil Red O-stained cells showed that lipid droplets decreased following Cape treatment as well as radical oxygen species forma

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14

Göçer, Hülya, and İlhami Gülçin. "Caffeic acid phenethyl ester (CAPE): correlation of structure and antioxidant properties." International Journal of Food Sciences and Nutrition 62, no. 8 (2011): 821–25. http://dx.doi.org/10.3109/09637486.2011.585963.

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15

Kart, Asim, Yilmaz Cigremis, Musa Karaman, and Hasan Ozen. "Caffeic acid phenethyl ester (CAPE) ameliorates cisplatin-induced hepatotoxicity in rabbit." Experimental and Toxicologic Pathology 62, no. 1 (2010): 45–52. http://dx.doi.org/10.1016/j.etp.2009.02.066.

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16

Tekin, Ahmet, Tevfik Küçükkartallar, Serdar Türkyılmaz, et al. "Effects of Caffeic Acid Phenethyl Ester (CAPE) on Sepsis in Rats." Inflammation 31, no. 4 (2008): 273–80. http://dx.doi.org/10.1007/s10753-008-9075-1.

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17

Gocer, Hulya, and Ilhami Gulcin. "Caffeic acid phenethyl ester (CAPE): a potent carbonic anhydrase isoenzymes inhibitor." International Journal of Academic Research 5, no. 4 (2013): 150–55. http://dx.doi.org/10.7813/2075-4124.2013/5-4/a.21.

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18

SON, Sopheak, Emil B. LOBKOWSKY, and Betty A. LEWIS. "Caffeic Acid Phenethyl Ester (CAPE): Synthesis and X-Ray Crstallographic Analysis." CHEMICAL & PHARMACEUTICAL BULLETIN 49, no. 2 (2001): 236–38. http://dx.doi.org/10.1248/cpb.49.236.

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19

Carreño, Ana Laura, Efrain Alday, Jael Quintero, et al. "Protective effect of Caffeic Acid Phenethyl Ester (CAPE) against oxidative stress." Journal of Functional Foods 29 (February 2017): 178–84. http://dx.doi.org/10.1016/j.jff.2016.12.008.

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20

Nagane, Masaki, Tadashi Yamashita, Patrik Vörös, Tamás Kálai, Kálmán Hideg, and Balázs Bognár. "Synthesis and evaluation of paramagnetic caffeic acid phenethyl ester (CAPE) analogs." Monatshefte für Chemie - Chemical Monthly 150, no. 8 (2019): 1513–22. http://dx.doi.org/10.1007/s00706-019-02458-8.

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21

Hébert, Martin J. G., Andrew J. Flewelling, Trevor N. Clark, et al. "Synthesis and Biological Activity of Arylspiroborate Salts Derived from Caffeic Acid Phenethyl Ester." International Journal of Medicinal Chemistry 2015 (March 5, 2015): 1–9. http://dx.doi.org/10.1155/2015/418362.

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Two novel boron compounds containing caffeic acid phenethyl ester (CAPE) derivatives have been prepared and characterized fully. These new compounds and CAPE have been investigated for potential antioxidant and antimicrobial properties and their ability to inhibit 5-lipoxygenase and whether chelation to boron improves their biological activity. Sodium salt 4 was generally more active than ammonium salt 5 in the biological assays and surpassed the radical scavenging ability of CAPE. Compounds 4 and 5 were more active than CAPE and Zileuton in human polymorphonuclear leukocytes. These results cl

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22

Yang, John, Gwendolyn A. Marriner, Xinyu Wang, Phillip D. Bowman, Sean M. Kerwin, and Salomon Stavchansky. "Synthesis of a series of caffeic acid phenethyl amide (CAPA) fluorinated derivatives: Comparison of cytoprotective effects to caffeic acid phenethyl ester (CAPE)." Bioorganic & Medicinal Chemistry 18, no. 14 (2010): 5032–38. http://dx.doi.org/10.1016/j.bmc.2010.05.080.

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23

Choi, Seon-Hee, Dong-Yeon Lee, Sohi Kang, et al. "Caffeic Acid Phenethyl Ester-Incorporated Radio-Sensitive Nanoparticles of Phenylboronic Acid Pinacol Ester-Conjugated Hyaluronic Acid for Application in Radioprotection." International Journal of Molecular Sciences 22, no. 12 (2021): 6347. http://dx.doi.org/10.3390/ijms22126347.

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We synthesized phenylboronic acid pinacol ester (PBPE)-conjugated hyaluronic acid (HA) via thiobis(ethylamine) (TbEA) linkage (abbreviated as HAsPBPE conjugates) to fabricate the radiosensitive delivery of caffeic acid phenetyl ester (CAPE) and for application in radioprotection. PBPE was primarily conjugated with TbEA and then PBPE-TbEA conjugates were conjugated again with hyaluronic acid using carbodiimide chemistry. CAPE-incorporated nanoparticles of HAsPBPE were fabricated by the nanoprecipitation method and then the organic solvent was removed by dialysis. CAPE-incorporated HAsPBPE nanop

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24

Yordanov, Yordan. "Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems." Pharmacia 66, no. 4 (2019): 223–31. http://dx.doi.org/10.3897/pharmacia.66.e38571.

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Propolis is a natural product with a plethora of biological effects, utilized by traditional medicine since antiquity. However, its application as a pharmaceutical is hindered by its variable composition and difficult standardization. CAPE has been shown to be a major component of propolis, with a large contribution to its pharmacological effects, among which the anti-inflammatory, antioxidant and antineoplastic have been attracting most attention. The current review article aims to present the cornerstone pharmacological studies of CAPE throughout the years, following its discovery, which con

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25

Kabała-Dzik, Agata, Anna Rzepecka-Stojko, Robert Kubina, Robert Dariusz Wojtyczka, Ewa Buszman, and Jerzy Stojko. "Caffeic Acid Versus Caffeic Acid Phenethyl Ester in the Treatment of Breast Cancer MCF-7 Cells: Migration Rate Inhibition." Integrative Cancer Therapies 17, no. 4 (2018): 1247–59. http://dx.doi.org/10.1177/1534735418801521.

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Epithelium mammary carcinoma is a cancer with a high death rate among women. One factor having a significant impact on metastasis is cell migration. The aim of this study was to compare migration rate inhibition of caffeic acid (CA) and its phenethyl ester (CAPE) on MCF-7 breast cancer cells. Microscopic evaluation was used to determine the morphology of carcinoma cells, before and after 24-hour treatment with CA and CAPE using a dose of 50 µM. The cytotoxic effect was measured by XTT-NR-SRB assay (tetrazolium hydroxide-neutral red-Sulforhodamine B) for 24-hour and 48-hour periods, using CA an

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Alici, Ozlem, Havva Sahin Kavakli, Cemile Koca, Neriman Defne Altintas, Murat Aydin, and Suleyman Alici. "Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats." Mediators of Inflammation 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/810948.

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Background and Aim. The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats.Materials and Methods. Twenty-four rats were randomly divided into three experimental groups: sham (group 1), sepsis (group 2), and sepsis + CAPE (group 3),n= 8 each. CAPE was administered (10 µmol/kg) intraperitoneally to group 3 before sepsis induction. Seru

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Altuntaş, Atila, H. Ramazan Yılmaz, Ayşegül Altuntaş, et al. "Caffeic Acid Phenethyl Ester Protects against Amphotericin B Induced Nephrotoxicity in Rat Model." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/702981.

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The present study was conducted to investigate whether caffeic acid phenethyl ester (CAPE), an active component of propolis extract, has a protective effect on amphotericin B induced nephrotoxicity in rat models. Male Wistar-Albino rats were randomly divided into four groups: (I) control group (n = 10), (II) CAPE group (n = 9) which received 10 μmol/kg CAPE intraperitoneally (i.p.), (III) amphotericin B group (n = 7) which received one dose of 50 mg/kg amphotericin B, and (IV) amphotericin B plus CAPE group (n = 7) which received 10 μmol/kg CAPE i.p. and one dose of 50 mg/kg amphotericin B. Th

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28

Chen, Ming-Jen, Shou-Chuan Shih, Horng-Yuan Wang, et al. "Caffeic Acid Phenethyl Ester Inhibits Epithelial-Mesenchymal Transition of Human Pancreatic Cancer Cells." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/270906.

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Background. This study aimed to investigate the effect of propolis component caffeic acid phenethyl ester (CAPE) on epithelial-mesenchymal transition (EMT) of human pancreatic cancer cells and the molecular mechanisms underlying these effects.Methods. The transforming growth factorβ(TGF-β-) induced EMT in human pancreatic PANC-1 cancer cells was characterized by observation of morphology and the expression of E-cadherin and vimentin by western blotting. The migration potential was estimated with wound closure assay. The expression of transcriptional factors was measured by quantitative RT-PCR

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Trumbeckaite, Sonata, Neringa Pauziene, Darius Trumbeckas, Mindaugas Jievaltas, and Rasa Baniene. "Caffeic Acid Phenethyl Ester Reduces Ischemia-Induced Kidney Mitochondrial Injury in Rats." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/1697018.

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During partial nephrectomy, the avoidance of ischemic renal damage is extremely important as duration of renal artery clamping (i.e., ischemia) influences postoperative kidney function. Mitochondria (main producer of ATP in the cell) are very sensitive to ischemia and undergo damage during oxidative stress. Finding of a compound which diminishes ischemic injury to kidney is of great importance. Caffeic acid phenethyl ester (CAPE), biologically active compound of propolis, might be one of the promising therapeutic agents against ischemia-caused damage. Despite wide range of biological activitie

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30

Akyol, Sumeyya, and Omer Akyol. "Multifaceted impact of caffeic acid phenethyl ester (CAPE) in experimental myocardial injuries." Anatolian Journal of Cardiology 15, no. 10 (2015): 848. http://dx.doi.org/10.5152/anatoljcardiol.2015.6336.

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31

Karaboğa, İhsan. "Caffeic Acid Phenethyl Ester (CAPE) Suppresses Systemic Inflammation In Rat Trauma Model." Journal of Apitherapy 4, no. 1 (2018): 31. http://dx.doi.org/10.5455/ja.20180702102008.

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32

Gießel, Josephine M., Anne Loesche, René Csuk, and Immo Serbian. "Caffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase." European Journal of Medicinal Chemistry 177 (September 2019): 259–68. http://dx.doi.org/10.1016/j.ejmech.2019.05.059.

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33

Erdemli, Haci Kemal, Sumeyya Akyol, Ferah Armutcu, and Omer Akyol. "The possible preventive effect of caffeic acid phenethyl ester (CAPE) against myringosclerosis." European Archives of Oto-Rhino-Laryngology 273, no. 3 (2015): 789–90. http://dx.doi.org/10.1007/s00405-015-3690-x.

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34

Shao, Bo, Li Mao, Miao Tang, et al. "Caffeic Acid Phenyl Ester (CAPE) Protects against Iron-Mediated Cellular DNA Damage through Its Strong Iron-Binding Ability and High Lipophilicity." Antioxidants 10, no. 5 (2021): 798. http://dx.doi.org/10.3390/antiox10050798.

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Caffeic acid phenethyl ester (CAPE) and its structurally-related caffeic acid (CA), ferulic acid (FA) and ethyl ferulate (EF) are constituents of honeybee propolis that have important pharmacological activities. This study found that CAPE—but not CA, FA, and EF—could effectively prevent cellular DNA damage induced by overloaded iron through decreasing the labile iron pool (LIP) levels in HeLa cells. Interestingly, CAPE was found to be more effective than CA in protecting against plasmid DNA damage induced by Fe(II)–H2O2 or Fe(III)–citrate–ascorbate-H2O2 via the inhibition of hydroxyl radical (

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35

Yılmaz, Ahmet, Bilal Elbey, Ümit Can Yazgan, et al. "Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study." BioMed Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/1247191.

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Background. The aim of the study was to analyse the effect of caffeic acid phenethyl ester (CAPE) on fluoxetine-induced hepatotoxicity in rats.Materials and Methods. Group I served as control. Group II received CAPE intraperitoneally. Group III received fluoxetine per orally. Group IV received fluoxetine and CAPE. The total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and liver enzymes including paraoxonase-1 (PON-1), aspartate transaminase, and alanine transaminase levels were measured. Liver tissues were processed histopathologically for evaluation of

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Zhou, YiFan, Jingqi Wang, Yanyu Chang, et al. "Caffeic Acid Phenethyl Ester Protects against Experimental Autoimmune Encephalomyelitis by Regulating T Cell Activities." Oxidative Medicine and Cellular Longevity 2020 (October 9, 2020): 1–13. http://dx.doi.org/10.1155/2020/7274342.

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Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) characterized by progressive demyelination and disabling outcomes. CD4+ T cells are the most critical driving factor of relapsing MS, but little improvement has been noted upon deletion of the whole T cell population. Caffeic acid phenethyl ester (CAPE), one of the main active compounds of propolis, exhibits potent antitumour, anti-inflammatory, and antioxidant properties by suppressing nuclear factor-κB (NF-κB) transactivation. To investigate the therapeutic potential of CAPE in MS, we studied th

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Paracatu, Luana Chiquetto, Carolina Maria Quinello Gomes Faria, Camila Quinello, et al. "Caffeic Acid Phenethyl Ester: Consequences of Its Hydrophobicity in the Oxidative Functions and Cytokine Release by Leukocytes." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/793629.

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Numerous anti-inflammatory properties have been attributed to caffeic acid phenethyl ester (CAPE), an active component of propolis. NADPH oxidases are multienzymatic complexes involved in many inflammatory diseases. Here, we studied the importance of the CAPE hydrophobicity on cell-free antioxidant capacity, inhibition of the NADPH oxidase and hypochlorous acid production, and release of TNF-α and IL-10 by activated leukocytes. The comparison was made with the related, but less hydrophobic, caffeic and chlorogenic acids. Cell-free studies such as superoxide anion scavenging assay, triene degra

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Yildiz, Oguz Galip, Serdar Soyuer, Recep Saraymen, and Celalettin Eroglu. "Protective effects of caffeic acid phenethyl ester on radiation induced lung injury in rats." Clinical & Investigative Medicine 31, no. 5 (2008): 242. http://dx.doi.org/10.25011/cim.v31i5.4870.

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Purpose: The prevention of radiation-induced pulmonary toxicity may help to improve radiation therapy in the cancer patient. The aim of this study was to investigate the pulmonary protective effects of caffeic acid phenethyl ester (CAPE), an antioxidant, on radiation-induced lung injury in rats. Methods:30 Wistar albino rats were divided into three groups and treated with saline, Radiation (RT) and RT + CAPE respectively. All rats were treated with CAPE (50 ?mol/kg i.p.) or saline. The first dose of CAPE was injected 24 h before radiation and application continued daily, with radiation in seco

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Karakuş, Fuat, Kadir Yılmaz, Ergül Eyol, and Songül Ünüvar. "Combination of 2 Bioactive Compounds for Treatment of Breast Cancer: Triterpenoid Cucurbitacin I and Phenolic CAPE." Natural Product Communications 14, no. 6 (2019): 1934578X1985749. http://dx.doi.org/10.1177/1934578x19857492.

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It has been demonstrated that both cucurbitacin I (Cu I) and caffeic acid phenethyl ester (CAPE) have anticancer activities. The current study aimed to examine the proliferation, migration, and colony formation actions of Cu I and CAPE on MCF-7 and MDA-MB-231 human breast cancer cells. The antimigration, antiproliferative, and colony inhibition effects of different dosages of Cu I, CAPE, and Cu I + CAPE on cells were determined by the 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) cell viability assay, wound healing, and colony formation assays, respectively. Compared with

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40

Kuramoto, Hitomi, Kouji Hirao, Hiromichi Yumoto, et al. "Caffeic Acid Phenethyl Ester (CAPE) Induces VEGF Expression and Production in Rat Odontoblastic Cells." BioMed Research International 2019 (December 21, 2019): 1–12. http://dx.doi.org/10.1155/2019/5390720.

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Caffeic acid phenethyl ester (CAPE), the main component of propolis, has various biological activities including anti-inflammatory effect and wound healing promotion. Odontoblasts located in the outermost layer of dental pulp play crucial roles such as production of growth factors and formation of hard tissue termed reparative dentin in host defense against dental caries. In this study, we investigated the effects of CAPE on the upregulation of vascular endothelial growth factor (VEGF) and calcification activities of odontoblasts, leading to development of novel therapy for dental pulp inflamm

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Hashimoto, Riichi, Hiyori Iai, Rie Fujita та ін. "Chemoenzymatic semisynthesis of caffeic acid β-phenethyl ester, an antioxidative component in propolis, from raw coffee bean extract". Bioscience, Biotechnology, and Biochemistry 85, № 3 (2020): 476–80. http://dx.doi.org/10.1093/bbb/zbaa077.

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ABSTRACT Caffeic acid β-phenethyl ester (CAPE), an antioxidative bioactive catechol isolated from propolis, was semisynthesized from chlorogenic acid and related compounds in an extract of raw (unroasted) Robusta coffee (Coffea canephora) beans in 5 steps and a total yield of 31%. Oxidative degradation of the intermediates and target molecule was prevented by alkaline hydrolysis of the chlorogenic acids in the presence of sodium dithionite (Na2S2O4) and deprotection of the catecholic diacetate precursor by Candida antarctica lipase B-mediated transesterification as the final step.

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Stošić, Biljana, Radmilo Janković, Marija Stošić, et al. "Caffeic acid phenethyl ester attenuates changes in pancreatic tissue damage biomarkers induced by cisplatin." Canadian Journal of Physiology and Pharmacology 98, no. 5 (2020): 296–303. http://dx.doi.org/10.1139/cjpp-2019-0374.

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Application of cisplatin (CP) for the treatment of different cancers is known to cause pancreatitis through an increase in reactive oxygen species production and promotion of inflammation. Caffeic acid phenethyl ester (CAPE), the main activity carrier of propolis extracts, was previously found to possess numerous beneficial properties. This study aims to determine for the first time the potential of CAPE in preventing CP-induced pancreatic tissue damage by studying the changes occurring on both biochemical and microscopic levels. The levels of serum α-amylase and a panel of pancreatic tissue b

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Wang, Jia, Priyanshu Bhargava, Yue Yu, et al. "Novel Caffeic Acid Phenethyl Ester-Mortalin Antibody Nanoparticles Offer Enhanced Selective Cytotoxicity to Cancer Cells." Cancers 12, no. 9 (2020): 2370. http://dx.doi.org/10.3390/cancers12092370.

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Caffeic acid phenethyl ester (CAPE) is a key bioactive ingredient of honeybee propolis and is claimed to have anticancer activity. Since mortalin, a hsp70 chaperone, is enriched in a cancerous cell surface, we recruited a unique cell internalizing anti-mortalin antibody (MotAb) to generate mortalin-targeting CAPE nanoparticles (CAPE-MotAb). Biophysical and biomolecular analyses revealed enhanced anticancer activity of CAPE-MotAb both in in vitro and in vivo assays. We demonstrate that CAPE-MotAb cause a stronger dose-dependent growth arrest/apoptosis of cancer cells through the downregulation

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HASTUTI, RIANI DWI, DIDING PRASETYO, and SRI HARTATI HADINOTO. "Perbedaan kadar caffeic acid phenethyl ester pada propolis ekstrak etanol dan propolis ekstrak air." Biofarmasi Journal of Natural Product Biochemistry 11, no. 2 (2013): 43–47. http://dx.doi.org/10.13057/biofar/f110203.

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Hastuti RD, Prasetyo D, Hadinoto SH. 2013. The difference of caffeic acid phenethyl ester level in ethanol extract propolis and water extract propolis. Biofarmasi 11: 43-47. Propolis is a natural product derived from plant resin collected by honeybeen and its composition has wide range of biological activity. CAPE is the ester of caffeic acid, a derivative of phenolic acid, a flavonoid-like compound, one of the major components of propolis. CAPE is reported can protect nephrotoxicity due to cisplatin induction, inhibiting the growth of various types of abnormal cells, having an anti-inflammati

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Kapare, Harshad S., Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi, and Kakasaheb Mahadik. "Formulation Development of Folic Acid Conjugated PLGA Nanoparticles for Improved Cytotoxicity of Caffeic Acid Phenethyl Ester." Pharmaceutical Nanotechnology 9, no. 2 (2021): 111–19. http://dx.doi.org/10.2174/2211738509666210111160528.

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Background: Honey bee propolis is one of the natural product reported in various traditional systems of medicines including Ayurveda. Caffeic acid phenethyl ester (CAPE) is an active constituent of propolis which is well known for its anticancer potential. The therapeutic effects of CAPE are restricted owing to its less aqueous solubility and low bioavailability. Objective: In this study CAPE loaded folic acid conjugated nanoparticle system (CLFPN) was investigated to enhance solubility, achieve sustained drug release and improved cytotoxicity of CAPE. Methods: Formulation development, charact

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Roy, Pierre-Philipe, Diene Faye, Sébastien Blanchard, et al. "New Caffeic Acid Phenylethyl Ester Analogs Bearing Substituted Triazole: Synthesis and Structure-Activity Relationship Study towards 5-Lipoxygenase Inhibition." Journal of Chemistry 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/2380531.

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Leukotrienes are biosynthesized by the conversion of arachidonic acid by 5-Lipoxygenase and play a key role in many inflammatory disorders. Inspired by caffeic acid phenylethyl ester (CAPE) (2) and an analog carrying a triazole substituted by cinnamoyl and 5-LO inhibitors recently reported by our team, sixteen new CAPE analogs bearing substituted triazole were synthesized by copper catalyzed Huisgen 1,3-dipolar cycloaddition. Compound 10e, an analog bearing p-CF3 phenethyl substituted triazole, was equivalent to CAPE (2) but clearly surpassed Zileuton (2), the only approved 5-LO inhibitor. Sub

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Cicala, Carla, Silvana Morello, Carolina Iorio, Raffaele Capasso, Francesca Borrelli, and Nicola Mascolo. "Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta." Life Sciences 73, no. 1 (2003): 73–80. http://dx.doi.org/10.1016/s0024-3205(03)00235-2.

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Watanabe, M. A. E., and J. M. Sforcin. "Effects of Propolis and Caffeic Acid Phenethyl Ester (CAPE) on Breast Cancer Cells." Current Pharmacogenomics and Personalized Medicine 16, no. 2 (2018): 88–93. http://dx.doi.org/10.2174/1875692116666180423143604.

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Trumbeckaitė, S., R. Banienė, M. Jievaltas, D. Trumbeckas, and M. Kinčius. "Caffeic acid phenethyl ester (CAPE) ameliorates ischemia-induced renal mitochondrial injury in rats." European Urology Supplements 13, no. 2 (2014): e1194. http://dx.doi.org/10.1016/s1569-9056(14)50048-6.

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Montpied, Pascale, Frédéric de Bock, Gérard Rondouin, et al. "Caffeic acid phenethyl ester (CAPE) prevents inflammatory stress in organotypic hippocampal slice cultures." Molecular Brain Research 115, no. 2 (2003): 111–20. http://dx.doi.org/10.1016/s0169-328x(03)00178-5.

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