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1

Samoggia, Antonella, and Tommaso Rezzaghi. "The Consumption of Caffeine-Containing Products to Enhance Sports Performance: An Application of an Extended Model of the Theory of Planned Behavior." Nutrients 13, no. 2 (2021): 344. http://dx.doi.org/10.3390/nu13020344.

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Caffeine is the most-used psychoactive substance in the world. About 80% of the world’s population consumes caffeine every day, including athletes and lifestyle users. Thus, it is important to understand the consumer drivers of caffeine-containing beverages and food. This research study aims to explore consumers’ behaviors, perceptions, attitudes, and drivers towards caffeine-containing products to enhance sports performance. The research applies the Theory of Planned Behavior (TPB) in order to understand consumers’ behavior, extended with utilitarian aspects for a comprehensive understanding
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Błaszczyk-Bębenek, Ewa, Beata Piórecka, Monika Kopytko, Zuzanna Chadzińska, Paweł Jagielski, and Małgorzata Schlegel-Zawadzka. "Evaluation of Caffeine Consumption among Pregnant Women from Southern Poland." International Journal of Environmental Research and Public Health 15, no. 11 (2018): 2373. http://dx.doi.org/10.3390/ijerph15112373.

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Caffeine is the most widely consumed stimulant worldwide, including by pregnant women. Products containing caffeine should be limited in accordance with the recommendations for pregnancy. The purpose of this study was to evaluate consumption of caffeinated products and daily caffeine intake from food by pregnant women. The study was conducted on a group of healthy pregnant women: attendees of antenatal classes (n = 70) and patients of an outpatient gynecological clinic (n = 70) from Krakow (Southern Poland). A questionnaire about the frequency of consumption of selected foods and drinks contai
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3

Johnson-Greene, Douglas, Michael Fatis, Donna Sonnek, and Carita Shawchuck. "A Survey of Caffeine Use and Associated Side Effects in a College Population." Journal of Drug Education 18, no. 3 (1988): 211–20. http://dx.doi.org/10.2190/6a9p-6q58-vjw9-2jjx.

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While caffeine ingestion is commonplace, there is a relative lack of research on normative standards of caffeine consumption. The present investigation surveyed two hundred and seventy students at a midwestern state university concerning their consumption of various caffeine products. The results of the investigation suggest that there is an identifiable group of individuals who use excessive amounts of caffeine. The survey has also identified several deleterious effects that may be related to caffeine use. The most important finding of the study was that roughly 75 percent of the individuals
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4

Fagerstrom, Karl. "A Comparison of Dependence across Different Types of Nicotine Containing Products and Coffee." International Journal of Environmental Research and Public Health 15, no. 8 (2018): 1609. http://dx.doi.org/10.3390/ijerph15081609.

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Introduction: Few studies have compared the dependence to different tobacco and nicotine products. Even less is known about how it relates to dependence on other common drugs, e.g., caffeine. In this study degree of dependence was compared between snus, cigarettes, nicotine replacement (NR), electronic cigarettes and coffee. Methods: A random sample of Swedish citizens belonging to an internet panel were contacted from September to October 2017. The responders were asked among other related things about their use of snus, NR, traditional cigarette or e-cigarette use and coffee consumption. The
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Chiang, W.-F., M.-T. Liao, C.-J. Cheng, and S.-H. Lin. "Rhabdomyolysis induced by excessive coffee drinking." Human & Experimental Toxicology 33, no. 8 (2013): 878–81. http://dx.doi.org/10.1177/0960327113510536.

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Excessive ingestion of caffeine-containing beverages is a rare cause of rhabdomyolysis. Here, we describe the case of a 44-year-old woman presented with nausea, vomiting, palpitations, and tea-colored urine 6 h after drinking a liter of black coffee containing approximately 565 mg of caffeine for mental alertness. Laboratory studies were notable for myoglobinuria and markedly elevated plasma creatine kinase (CK) level of 7315 U/L. With volume expansion and alkalization, her plasma CK level returned to normal within 5 days. Rhabdomyolysis should be considered a potential health hazard from exce
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Stachyshyn, Saskia, Ajmol Ali, Carol Wham, Tayla Knightbridge-Eager, and Kay Rutherfurd-Markwick. "Caffeine Consumption Habits of New Zealand Tertiary Students." Nutrients 13, no. 5 (2021): 1493. http://dx.doi.org/10.3390/nu13051493.

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Adverse effects associated with excessive caffeine consumption combined with increasing numbers and availability of caffeine-containing products are causes for concern. Tertiary students may be at increased risk of consuming excessive amounts of caffeine due to seeking caffeinated products with well-known wakefulness effects and cognitive benefits. This study explored caffeine consumption habits of New Zealand tertiary students (317; ≥16-years) using a previously validated caffeine consumption habits (CaffCo) questionnaire. Most (99.1%) regularly consumed caffeinated products, especially choco
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Musharraf, Fatima Fakhir, Asad Ali Siddiqui, Muhammad Mustafa Ali, Shazia Fakhir Durrani, Fatima Abid, and Aijaz Qureshi. "Assessment of Trends of Consumption of Caffeine Containing Products and their Effects on Medical Undergraduate Students." Journal of Bahria University Medical and Dental College 13, no. 01 (2022): 56–60. http://dx.doi.org/10.51985/jbumdc202293.

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Objectives: To assess trend of consumption and withdrawal effects from caffeine containing products among medical undergraduate students of Karachi. Study design and setting: Cross-sectional study conducted via web-based questionnaire, from January 2020 to June 2021. Methodology: Undergraduate medical, MBBS students aged 18-24 years, studying in 6 different medical universities of Karachi were included in the study. An online survey was conducted. An online questionnaire was designed which consisted of 28 self-made questions that focused on collecting basic sociodemographic information, coffee
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8

Lieberman, Harris R. "Why Are Certain Caffeine-Containing Products Associated With Serious Adverse Effects?" Mayo Clinic Proceedings 95, no. 8 (2020): 1562–64. http://dx.doi.org/10.1016/j.mayocp.2020.06.032.

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9

Błaszczyk-Bębenek, Ewa, Paweł Jagielski, and Małgorzata Schlegel-Zawadzka. "Caffeine Consumption in a Group of Adolescents from South East Poland—A Cross Sectional Study." Nutrients 13, no. 6 (2021): 2084. http://dx.doi.org/10.3390/nu13062084.

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Caffeine is the most common psychoactive substance available to adults, as well as to children and adolescents. The safety of its use in younger age groups requires further research. The aim of this study was to evaluate caffeine intake, to identify products and drinks that are the main sources of caffeine intake in the diet of the subjects and the risk of excessive caffeine intake with the diet of adolescents, stratified by gender. A cross-sectional study was conducted among 508 adolescents aged 16–18 years from southern Poland. Black tea, cola-based soft drinks and milk chocolate were the mo
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Diamai, Siewdorlang, Icydora Kharkongor, Eveningstar Ryntathiang, and Rodridge Russel Kharbudon. "Caffeine Extraction from Local Tea Leaves and its Estimation by Iodometric Method." Spectrum: Science and Technology 9, no. 1 (2022): 35–41. http://dx.doi.org/10.54290/spect/2022.v9.1.0004.

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The principal constituent of tea, which is responsible for all the properties, is the alkaloid caffeine. Theanine is an amino acid found only in tea leaves, which imparts a pleasantly sweet taste to tea. It is degraded to glutamic acid and has relaxation effects in humans. Caffeine is a bitter, white crystalline xanthine alkaloid and a stimulant drug. It is found in varying quantities in the seeds, leaves, and fruit of some plants, where it acts as a natural pesticide that paralyses and kills certain insects feeding on the plants, as well as enhancing the reward memory of pollinators. It is al
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Pedriali Moraes, Carla Aparecida. "Comparative analysis of anti-cellulite market products containing vegetal cosmetic assets." Journal of Dermatology & Cosmetology 3, no. 1 (2019): 26–30. http://dx.doi.org/10.15406/jdc.2019.03.00110.

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Introduction: Cellulite is characterized by a weakness of the fascia which accumulates fat lobules alongside irregular lobular hypertrophy that causes skin dimpling and occurs mostly in women after puberty. Cellulite may arise from a sum of different conditions, such as emotional alterations, genetics, sedentary lifestyle, hormones, weight gain and poor nutrition. There are several techniques designed to prevent and treat cellulite, but consumers prefer topical lotions and creams due to them being more affordable. This work aimed to review studies published in scientific literature on major pl
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Hassan, Amir, Muhammad Ashfaq, Ali Khan, and Muhammad Shakeel Khan. "Isolation of Caffeine from Carbonated Beverages." Journal of Tropical Pharmacy and Chemistry 5, no. 1 (2020): 33–38. http://dx.doi.org/10.25026/jtpc.v5i1.234.

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The work presented on the isolation of naturally occurring alkaloid from carbonated beverages. The extensive presence of caffeine in different plants plays an important role in the long-standing acceptance of caffeine-containing products. Caffeine (3,7-dihydro-1, 3,7-trimethyl-1H-purine-2,6-dione or 1,3,7-trimethylxanthine) is an alkaloid belongs to Methylxanthine family. Liquid-liquid extraction methods were used in the assay of research work. Chloroform was taken as extracting solvent. Solid residue of caffeine was recrystallized from 95% ethanol using 5ml/gram (5ml per gram). It is declared
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Roman, Mark C., Jana Hildreth, and Silvia Bannister. "Determination of Catechins and Caffeine in Camillia sinensis Raw Materials, Extracts, and Dietary Supplements by HPLC-UV: Single-Laboratory Validation." Journal of AOAC INTERNATIONAL 96, no. 5 (2013): 933–41. http://dx.doi.org/10.5740/jaoacint.10-488.

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Abstract A rapid method has been developed to quantify seven catechins and caffeine in green tea (Camillia sinensis) raw material and powdered extract, and dietary supplements containing green tea extract. The method utilizes RP HPLC with a phenyl-based stationary phase and gradient elution. Detection is by UV absorbance. The total run time, including column re-equilibration, is 13 min. Single-laboratory validation (SLV) has been performed on the method to determine the repeatability, accuracy, selectivity, LOD, LOQ, ruggedness, and linearity for (+)-catechin, (–)-epicatechin, (–)-epicatechin
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14

Gonda, Jozef, Pavol Kristian, and Ľubomír Mikler. "Synthesis of isothiocyanates from non-aromatic nitrogen-containing heterocycles." Collection of Czechoslovak Chemical Communications 51, no. 1 (1986): 112–17. http://dx.doi.org/10.1135/cccc19860112.

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Investigation of the reaction of thiophosgene with Δ2-oxazolines I, Δ3-thiazolines II, 4H-benzo[d][1,3]thiazines III, 2-methoxypentahydro-Δ1-azepine IV, theophylline and caffeine showed that only compounds I and IV reacted to give 2-acyloxyethyl isothiocyanates and methyl 6-isothiocyanatohexanoate. The structure of these products was corroborated by IR, 1H NMR, 13C NMR and mass spectral methods. The suitability of the above-mentioned compounds to react is discussed.
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15

Andrews, Karen W., Amy Schweitzer, Cuiwei Zhao, et al. "The caffeine contents of dietary supplements commonly purchased in the US: analysis of 53 products with caffeine-containing ingredients." Analytical and Bioanalytical Chemistry 389, no. 1 (2007): 231–39. http://dx.doi.org/10.1007/s00216-007-1437-2.

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16

Kharaba, Zelal, Nour Sammani, Samar Ashour, et al. "Caffeine Consumption among Various University Students in the UAE, Exploring the Frequencies, Different Sources and Reporting Adverse Effects and Withdrawal Symptoms." Journal of Nutrition and Metabolism 2022 (May 18, 2022): 1–7. http://dx.doi.org/10.1155/2022/5762299.

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Background. Caffeine is widely consumed among students due to its cognitive and physical enhancing effects. However, little is known about the consumption pattern of different caffeinated products among university students in the United Arab Emirates (UAE). Aim. To investigate the frequency of caffeine consumption among the young population of students, assess types of caffeinated products consumed, and document adverse effects and withdrawal symptoms experienced by university students. Methods. A cross-sectional study was conducted in the UAE from December 2019 to March 2020. A random sample
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17

Carlson, Marvin, and Richard D. Thompson. "Liquid Chromatographic Determination of Methylxanthines and Catechins in Herbal Preparations Containing Guaraná." Journal of AOAC INTERNATIONAL 81, no. 4 (1998): 691–701. http://dx.doi.org/10.1093/jaoac/81.4.691.

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Abstract Herbal preparations derived from the dried seeds of guarana (Paullinia cupana) have become a popular nutritional supplement used for stimulatory purposes. Once considered a drug substance in the United States, guaraná currently is classified as a food additive and dietary supplement. The pharmacological activity of guaraná-containing products is primarily due to methylxanthine alkaloids. For guaraná preparations, methylxanthine levels and, more significantly, the presence of several polyphenol compounds (i.e., catechins) provide phytochemical markers of authenticity. Methylxanthines a
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18

Raschitor, Alexandra, Alberto Romero, Sandra Sanches, Vanessa J. Pereira, Joao G. Crespo, and Javier Llanos. "Degradation of Neonicotinoids and Caffeine from Surface Water by Photolysis." Molecules 26, no. 23 (2021): 7277. http://dx.doi.org/10.3390/molecules26237277.

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Along with rapid social development, the use of insecticides and caffeine-containing products increases, a trend that is also reflected in the composition of surface waters. This study is focused on the phototreatment of a surface water containing three neonicotinoids (imidacloprid, thiamethoxam, and clothianidin) and caffeine. Firstly, the radiation absorption of the target pollutants and the effect of the water matrix components were evaluated. It was observed that the maximum absorption peaks appear at wavelengths ranging from 246 to 274 nm, and that the water matrix did not affect the effi
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19

Higashi. "Coffee and Endothelial Function: A Coffee Paradox?" Nutrients 11, no. 9 (2019): 2104. http://dx.doi.org/10.3390/nu11092104.

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Coffee is a popular beverage throughout the world. Coffee contains various chemical compounds (e.g., caffeine, chlorogenic acids, hydroxyhydroquinone, kahweol, cafestol, and complex chemical mixtures). Caffeine is also the most widely consumed pharmacological substance in the world and is included in various beverages (e.g., coffee, tea, soft drinks, and energy drinks), products containing chocolate, and drugs. The effects of coffee and caffeine on cardiovascular diseases remain controversial. It is well known that there are J-curve-type or U-curve-type associations of coffee consumption with
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20

Riera-Sampol, Aina, Lluis Rodas, Sonia Martínez, Hannah J. Moir, and Pedro Tauler. "Caffeine Intake among Undergraduate Students: Sex Differences, Sources, Motivations, and Associations with Smoking Status and Self-Reported Sleep Quality." Nutrients 14, no. 8 (2022): 1661. http://dx.doi.org/10.3390/nu14081661.

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Due to its stimulatory effects, caffeine is one of the most frequently consumed mood and behavior altering drugs. University students report using caffeine-containing products to enhance mood and performance or for a desire of alertness. The current study investigated caffeine consumption in university undergraduate students, and associations with smoking status, alcohol and cannabis consumption, fruit and vegetable consumption, and sleep quality. Motivations for caffeine intake were also ascertained. A total of 886 undergraduates aged 18–25 years from the University of the Balearic Islands pa
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21

Samoggia, Antonella, Pietro Landuzzi, and Carmen Enriqueta Vicién. "Market Expansion of Caffeine-Containing Products: Italian and Argentinian Yerba Mate Consumer Behavior and Health Perception." International Journal of Environmental Research and Public Health 18, no. 15 (2021): 8117. http://dx.doi.org/10.3390/ijerph18158117.

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Mate is the most consumed beverage in South America. There is interest in expanding yerba mate sales into the old and new markets by promoting its health properties and energizing effects. The research study aims to explore Argentinian and Italian purchasing and consumption behavior and perception of yerba mate. The exploration includes agro-food chain stakeholders’ views, and consumers’ habits, perception, knowledge of yerba mate in relation to other market positioning caffeine-containing products. Data collection includes qualitative method, such as interviews with agro-food chain stakeholde
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Schmitt, Gabriela C., Marcelo D. Arbo, Andréia L. Lorensi, et al. "Toxicological Effects of a Mixture Used in Weight Loss Products: p-Synephrine Associated With Ephedrine, Salicin, and Caffeine." International Journal of Toxicology 31, no. 2 (2012): 184–91. http://dx.doi.org/10.1177/1091581811435708.

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p-Synephrine is an adrenergic amine found in Citrus aurantium L. fruits and has been used for weight loss in dietary supplements. There are commercial products containing this substance associated to caffeine, salicin, and ephedrine. The aim of this study was to evaluate the acute toxicity of this mixture in mice of both sexes. The significative results observed after acute oral administration to male and female mice of 300, 350, and 400 mg/kg total of p-synephrine, ephedrine, salicin, plus caffeine in a 10:4:6:80 w/w ratio included a reduction in locomotor activity and ptosis in all treated g
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Sullivan, Caitlin, and Joseph Sherma. "Development and Validation of a Method for Determination of Caffeine in Diuretic Tablets and Capsules by High-Performance Thin-Layer Chromatography on Silica Gel Plates with a Concentration Zone Using Manual Spotting and Ultraviolet Absorption Densitometry." Journal of AOAC INTERNATIONAL 88, no. 5 (2005): 1537–43. http://dx.doi.org/10.1093/jaoac/88.5.1537.

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Abstract A new quantitative method using silica gel high-performance thin-layer chromatography plates with channels and a concentration zone, manual application of standards and samples, development with methanol–ethyl acetate (15 + 85) mobile phase, and ultraviolet absorption densitometry is reported for the determination of caffeine in diuretic pharmaceutical preparations. Tablet and capsule products containing potassium salicylate, acetaminophen, and salicylamide as active ingredients were analyzed to test the applicability of the new method, and precision, accuracy, linearity, limits of de
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Badea, Delia Nica, and Codrina Levai. "Separation and Detection of Caffeine, Theophylline and Theobromine from Coffee Varieties, Carbonated Soft Drinks and Alcoholic Beverages." Revista de Chimie 68, no. 11 (2017): 2704–7. http://dx.doi.org/10.37358/rc.17.11.5959.

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The paper evaluates the presence of methyl xanthine compounds: caffeine, theophylline, theobromine used as ingredients in carbonated soft drinks or as color and flavor ingredients in alcoholic beverages. The active components extracted from the selected products (coffee, tea, drinks) was separated and identified chromatographically using plates with silica nano -Sil NH2 / UV-254, mobile phase ethanol - water (50: 1, 50: 3, 50: 5; 50: 7; v / v) and 60 F254 plates, mobile phase acetone-toluene-chloroform (40:30:30 v / v). Separated caffeine and identified by TLC was analyzed using a HelWet Packa
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Komes, D., D. Horžić, A. Belščak, K. Kovačević Ganič, and A. Baljak. "Determination of Caffeine Content in Tea and Maté Tea by using Different Methods." Czech Journal of Food Sciences 27, Special Issue 1 (2009): S213—S216. http://dx.doi.org/10.17221/612-cjfs.

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Caffeine-containing products have been consumed for hundreds of years for their pleasant flavor and stimulating effects. In recent years, caffeine received increasing attention in food and pharmaceutical industries, due to its pharmacological properties which comprise stimulation of the central nervous system, peripheral vasoconstriction, relaxation of the smooth muscle and myocardial stimulation. The aim of this study was to determine the content of caffeine in five types of tea (white, yellow, green, oolong, black) and two types of maté tea (green maté and roasted maté tea). The content of c
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Moaddeb, Jivan, Toyin S. Tofade, and Michael B. Bevins. "Hypertensive Urgency Associated With Xenadrine EFX Use." Journal of Pharmacy Practice 24, no. 4 (2011): 400–403. http://dx.doi.org/10.1177/0897190011406127.

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Several supplements and herbal products have been shown to increase catecholamines and subsequently mean arterial pressure and systemic vascular resistance. Since ephedra-containing products have been removed from the market, manufacturers of weight loss herbal supplements must produce ephedra-free formulations. Xenadrine EFX is an ephedra-free weight loss product containing a mixture of caffeine, guarana, and bitter orange (standardized to synephrine). Synephrine has been shown in animals and humans to increase systemic vascular resistance and mean arterial pressure. We present a case of a pa
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Do, Tiên, Isaline Santi, and Eike Reich. "A harmonized HPTLC method for identification of various caffeine containing herbal drugs, extracts, and products, and quantitative estimation of their caffeine content." Journal of Liquid Chromatography & Related Technologies 42, no. 9-10 (2019): 274–81. http://dx.doi.org/10.1080/10826076.2019.1585612.

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Andrews, Karen, Pavel Gusev, Phuong-Tan Tey, et al. "Content of Caffeine and Catechins Measured in Multi-ingredient Dietary Supplements Containing Green Tea: Association with Label Claims and Proprietary Blends." Current Developments in Nutrition 4, Supplement_2 (2020): 1375. http://dx.doi.org/10.1093/cdn/nzaa061_003.

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Abstract Objectives Multi-ingredient dietary supplements (DSs) containing green tea (GT) were analyzed for their phytochemical content (seven catechins and caffeine) as part of a Dietary Supplement Ingredient Database project. The label information required by FDA is the weight of the GT extract or leaf powder, unless it is part of a proprietary blend (only the blend weight needed). Any information about the concentration of GT phytochemicals is voluntary. We assessed the accuracy of the mandatory and voluntary portions of labels and the effect of proprietary blends on the phytochemical conten
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Roth, Anna, and Tomasz Zawadzki. "INSTAGRAM AS A TOOL FOR PROMOTING SUPERFOOD PRODUCTS." Annals of Marketing Management and Economics 4, no. 1 (2018): 101–13. http://dx.doi.org/10.22630/amme.2018.4.1.8.

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Social media, Instagram included, are more and more often used by enterprises to promote their own products. Year by year there has been an increase in the rate of the use of the analysed channels of marketing, which seem to be one of the most basic forms of spreading information about their products for enterprises active in the field of superfood products. Superfoods are products containing elements characterised by a wealth of nutritional values, e.g. chia seeds or goji berries. The article presents a short characteristic of social media and defines the eponymous superfood category. The res
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Petrov, Viacheslav, Rebecca J. Dooley, Alexander A. Marchione, Elizabeth L. Diaz, Brittany S. Clem, and William Marshall. "Synthesis of purines and adenines containing the hexafluoroisopropyl group." Beilstein Journal of Organic Chemistry 16 (November 11, 2020): 2739–48. http://dx.doi.org/10.3762/bjoc.16.224.

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Several new derivatives of adenine, purine, and theophylline containing the (CF3)2CH group connected to a nitrogen atom of the imidazole ring were prepared by the reaction of 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane (1) with the corresponding substrates, resulting in the selective alkylation of one of the nitrogen atoms of the imidazole ring. The reaction proceeds under mild conditions in a polar solvent, giving the alkylated products in 47–78% yield. While for purine and 4- and 5-azabenzimidazole, the reaction led to a mixture of two isomers, the reaction of adenine and the correspond
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Jagim, Andrew R., Patrick S. Harty, Karen M. Fischer, Chad M. Kerksick, and Jacob L. Erickson. "Adverse Events Reported to the United States Food and Drug Administration Related to Caffeine-Containing Products." Mayo Clinic Proceedings 95, no. 8 (2020): 1594–603. http://dx.doi.org/10.1016/j.mayocp.2020.02.033.

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Greer, Felicia, Jacobo Morales, and Michael Coles. "Wingate performance and surface EMG frequency variables are not affected by caffeine ingestion." Applied Physiology, Nutrition, and Metabolism 31, no. 5 (2006): 597–603. http://dx.doi.org/10.1139/h06-030.

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The ergogenic effect of caffeine and its mechanism of action on short-term, high-intensity exercise are controversial. One proposed mechanism is caffeine’s stimulatory effect on the central nervous system and thus, motor-unit excitation. The latter is non-invasively determined from surface electromyographic signal (EMG) frequency measures. The purpose of this study was to determine if power output and surface EMG frequency variables during high-intensity cycling were altered following caffeine ingestion. Eighteen recreationally active college males (mean ± SD age, 21.5 ± 1.8 y; height, 181.8 ±
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Bukhari, Asma S., John A. Caldwell, Adam J. DiChiara, et al. "Caffeine, Energy Beverage Consumption, Fitness, and Sleep in U.S. Army Aviation Personnel." Aerospace Medicine and Human Performance 91, no. 8 (2020): 641–50. http://dx.doi.org/10.3357/amhp.5588.2020.

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BACKGROUND: Caffeine-containing products and dietary supplements are widely used by military populations, but little is known about their use by aviation personnel. This study assessed self-reported sleep, fitness, work-schedules, and caffeine/energy drink use.METHODS: A standardized survey was conducted in person by study personnel using tablet computers. A total of 188 aircrew members from the Combat Aviation Brigade at Fort Campbell, KY, participated in the survey. Focus groups were conducted with a subset of 47 subjects.RESULTS: The majority of subjects reported their physical fitness, hea
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Genady, Afaf, Mohamed El-Zaria, and Detlef Gabel. "Synthesis and characterization of azanonaborane-containing purine derivatives for boron neutron capture therapy." Open Chemistry 6, no. 2 (2008): 154–60. http://dx.doi.org/10.2478/s11532-008-0008-5.

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AbstractDerivatives of purine, adenine, guanine, and 2,6-diaminopurine linked to the azanonaborane (B8N cluster) have been prepared, for possible use as powerful agents for boron neutron capture therapy (BNCT). The synthesis was carried out via a ligand exchange reaction. The exo-NH2R group of the azanonaborane of the type [(RH2N)B8H11NHR] can be exchanged by one hetero-nitrogen atom of the pyrimidine ring, and except for guanine, also by an N atom of the imidazole ring. The identity of the products was confirmed by NMR, elemental analysis, IR, and mass spectrometry. No reaction was found to o
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Sousa, Sandra Alves de, Henrique Pascoa, Edemilson Cardoso da Conceição, et al. "Dissolution test of herbal medicines containing Paullinia cupana: validation of methods for quantification and assessment of dissolution." Brazilian Journal of Pharmaceutical Sciences 47, no. 2 (2011): 269–77. http://dx.doi.org/10.1590/s1984-82502011000200008.

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"Guaraná" (Paullinia cupana) is used as a physical activity enhancer and stimulator due to its methylxanthines and condensed tannins. The aim of this work was to evaluate the dissolution behavior of five herbal medicines in the form of capsules and tablets containing guaraná. Assay and dissolution methods were validated and results obtained allowed simultaneous marker quantification with precision, accuracy, selectivity and robustness. Findings showed that 100% of the herbal medicinal products analyzed did not provide satisfactory results concerning the presence of four markers, 60% had three
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Jagim, Andrew R., Patrick S. Harty, Abdelrahman R. Barakat, et al. "Prevalence and Amounts of Common Ingredients Found in Energy Drinks and Shots." Nutrients 14, no. 2 (2022): 314. http://dx.doi.org/10.3390/nu14020314.

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Background: Energy drinks are one of the most popular packaged beverage products consumed within the United States (US). Energy drinks are considered a functional beverage, a category that also includes sports drinks and nutraceutical beverages. Purpose: The focus of the current study was to examine the nutrition fact panels of the top selling commercially available energy drink and energy shot products within the US to characterize common ingredient profiles to help establish a standard definition and ingredient profile of energy drinks and energy shots for consumers, health care practitioner
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Betz, Joseph M., Martha L. Gay, Magdi M. Mossoba, Sarah Adams, and Barbara S. Portz. "Chiral Gas Chromatographic Determination of Ephedrine-Type Alkaloids in Dietary Supplements Containing Má Huáng." Journal of AOAC INTERNATIONAL 80, no. 2 (1997): 303–15. http://dx.doi.org/10.1093/jaoac/80.2.303.

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Abstract Má Huáng is a traditional Chinese medicine derived from the aerial parts of several Ephedra species (Ephedraceae). These plants produce (–)-ephed- rine, (+)-pseudoephedrine, (–)-norephedrine, (+)- norpseudoephedrine, (–)-N-methylephedrine, and (+)-N-methylpseudoephedrine. Racemic and (–)- ephedrine, (+)-pseudoephedrine, and (±)-norephe- drine (phenylpropanolamine) are used clinically in the United States and are largely synthetic in origin. Current interest in Má Huáng is spurred by reports describing a “thermogenic” (calorie burning) effect provided by mixtures of ephedrine, caffeine
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Lawrence, John R., George D. W. Swerhone, Leonard I. Wassenaar, and Thomas R. Neu. "Effects of selected pharmaceuticals on riverine biofilm communities." Canadian Journal of Microbiology 51, no. 8 (2005): 655–69. http://dx.doi.org/10.1139/w05-047.

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Although pharmaceutical and therapeutic products are widely found in the natural environment, there is limited understanding of their ecological effects. Here we used rotating annular bioreactors to assess the impact of 10 µg·L–1of the selected pharmaceuticals ibuprofen, carbamazepine, furosemide, and caffeine on riverine biofilms. After 8 weeks of development, community structure was assessed using in situ microscopic analyses, fluor-conjugated lectin binding, standard plate counts, fluorescent in situ hybridization, carbon utilization spectra, and stable carbon isotope analyses. The biofilm
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Gonçalves, João L., Vera L. Alves, Joselin Aguiar, Maria J. Caldeira, Helena M. Teixeira, and José S. Câmara. "Structure Assignment of Seized Products Containing Cathinone Derivatives Using High Resolution Analytical Techniques." Metabolites 11, no. 3 (2021): 144. http://dx.doi.org/10.3390/metabo11030144.

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The innovation of the new psychoactive substances (NPS) market requires the rapid identification of new substances that can be a risk to public health, in order to reduce the damage from their use. Twelve seized products suspected to contain illicit substances were analyzed by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), gas chromatography coupled to mass spectrometry (GC-MS), and nuclear magnetic resonance spectroscopy (NMR). Synthetic cathinones (SCat) were found in all products, either as a single component or in mixtures. Infrared spectra of all products
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Wojciechowska, Katarzyna, Maria Zun, Dorota Dwornicka, Katarzyna Swiader, Regina Kasperek, and Ewa Poleszak. "Physical properties and caffeine release from creams prepared with different oils." Current Issues in Pharmacy and Medical Sciences 27, no. 4 (2014): 224–28. http://dx.doi.org/10.1515/cipms-2015-0020.

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Abstract Caffeine is a methylxanthine typically found in the Coffee Arabica L plant. Generally, caffeine is well-known as a orally administered mild stimulant of the central nervous system. However, for cosmetic purpose, caffeine is an active compound ingredient, at 7% concentration, in several anticellulite products. The efficiency of this mode of delivery is not fully understood. Hence, the aim of the study was to ascertain the effectiveness of particular carriers to release this ingredient. In so doing, we prepared six creams based upon different oils (Sesame oil, Rice oil, Walnut oil, Coco
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Durnova, N. A., A. Yu Karetnikova, D. S. Isaev, A. R. Klantsataya, and A. S. Sheremetyeva. "Complex effect of caffeine and dioxidine on behavioral responses in mice in Porsolt test." RUDN Journal of Medicine 24, no. 4 (2020): 315–24. http://dx.doi.org/10.22363/2313-0245-2020-24-4-315-324.

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Relevance. In light of the popularization of the use of caffeine-containing products, the question of the combined use of caffeine with substances exhibiting a toxic effect remains open. The doses of caffeine, which have a pronounced antidepressant effect, are also insufficiently studied. The aim of the study was to study the effect of repeated administration of caffeine and dioxidine on the behavioral responses of mice in the Porsolt test. Materials and methods. The experiment was carried out on 36 outbred male mice, divided into 6 groups. Experimental groups for 15 days of the study received
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Filippova, A. V., A. P. Pereverzev, E. Yu Ebzeeva, and O. D. Ostroumova. "Mildronate. Chronic fatigue syndrome." Medical alphabet, no. 7 (June 16, 2020): 15–20. http://dx.doi.org/10.33667/2078-5631-2020-7-15-20.

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Chronic fatigue syndrome (CFS) is a state of constant, impairing quality of life, fatigue, lasting more than 6 months, inexplicable by any of coexisting patient’s pathological conditions. The prevalence of CFS in the world is approximately 2 % of the population (120–140 mln inhabitants of Earth). The etiology of CFS is unknown. Several theories of development of CFS have been proposed (immune, infectious, endocrine, metabolic, neurological, psychiatric), however, none of them fully explains the clinical manifestations of CFS. There is no specific treatment for this condition. This article pres
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Imshinetskiy, Igor, Victoria Kashepa, Konstantine Nadaraia, et al. "PEO Coatings Modified with Halloysite Nanotubes: Composition, Properties, and Release Performance." International Journal of Molecular Sciences 24, no. 1 (2022): 305. http://dx.doi.org/10.3390/ijms24010305.

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In this work, the properties of the coatings formed on the Mg-Mn-Ce alloy by plasma electrolytic oxidation (PEO) in electrolytes containing halloysite nanotubes (HNTs) were investigated. The incorporation of halloysite nanotubes into the PEO coatings improved their mechanical characteristics, increased thickness, and corrosion resistance. The studied layers reduced corrosion current density by more than two times in comparison with the base PEO layer without HNTs (from 1.1 × 10–7 A/cm2 to 4.9 × 10–8 A/cm2). The presence of halloysite nanotubes and products of their dihydroxylation that were fo
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Pilegaard, Kirsten, Anne Sophie Majgaard Uldall, and Gitte Ravn-Haren. "Intake of Food Supplements, Caffeine, Green Tea and Protein Products among Young Danish Men Training in Commercial Gyms for Increasing Muscle Mass." Foods 11, no. 24 (2022): 4003. http://dx.doi.org/10.3390/foods11244003.

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Sixty-three men (15–35 years of age) regularly training in Danish gyms and supplement users were interviewed about the use of supplemental protein and food supplements, intake of caffeine- and (-)-epigallocathechin-3-gallate (EGCG)-containing supplements and beverages and any experienced adverse effects. Protein powder (60%), fish oil (54%) and multivitamin/mineral supplements (41%) were the most popular products. The daily supplementary protein intake (mean 0.42 g/kg body weight, users only) in adult men contributed substantially to their protein intake and exceeded the recommended allowance
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Schmitt, Gabriela Cristina, Marcelo Dutra Arbo, Andréia Louise Lorensi, et al. "Gender differences in biochemical markers and oxidative stress of rats after 28 days oral exposure to a mixture used for weight loss containing p-synephrine, ephedrine, salicin, and caffeine." Brazilian Journal of Pharmaceutical Sciences 52, no. 1 (2016): 59–68. http://dx.doi.org/10.1590/s1984-82502016000100007.

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ABSTRACT The association of p-synephrine, ephedrine, salicin, and caffeine in dietary supplements and weight loss products is very common worldwide, even though ephedrine has been prohibited in many countries. The aim of this study was to evaluate a 28-day oral exposure toxicity profile of p-synephrine, ephedrine, salicin, and caffeine mixture (10:4:6:80 w/w respectively) in male and female Wistar rats. Body weight and signs of toxicity, morbidity, and mortality were observed daily. After 28 days, animals were euthanized and blood collected for hematological, biochemical, and oxidative stress
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A, Babagana, Hassan LG, Mshelia HE, Liman MG, Maiyama SY, and Ahmed M. "Characterization and Toxicity Studies of Caffeine Isolated from Root Bark Extract of Piliostigma thonningii (Schum.)." Arid Zone Journal of Basic and Applied Research 1, no. 2 (2022): 36–47. http://dx.doi.org/10.55639/607ciou.

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Caffeine is the most frequently ingested pharmacologically active substance in the World. It is found in common coffee, tea, soft drinks, in products containing cocoa or chocolate, and in medications among others. Because of its wide consumption at different levels by most of the people, the scientific community as well as the general public have expressed interest in the potential for caffeine to produce adverse effects on human health. This study was carried out to isolate and characterize caffeine from root bark extract of Piliostigma thonningii and to study the toxicity profile of the isol
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Robles-Martinez, Pamela, Xiaoyan Xu, Sarah J. Trenfield, et al. "3D Printing of a Multi-Layered Polypill Containing Six Drugs Using a Novel Stereolithographic Method." Pharmaceutics 11, no. 6 (2019): 274. http://dx.doi.org/10.3390/pharmaceutics11060274.

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Three-dimensional printing (3DP) has demonstrated great potential for multi-material fabrication because of its capability for printing bespoke and spatially separated material conformations. Such a concept could revolutionise the pharmaceutical industry, enabling the production of personalised, multi-layered drug products on demand. Here, we developed a novel stereolithographic (SLA) 3D printing method that, for the first time, can be used to fabricate multi-layer constructs (polypills) with variable drug content and/or shape. Using this technique, six drugs, including paracetamol, caffeine,
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48

Truter, I. "Prescribing of meprobamate-containing combination analgesics in South Africa." South African Family Practice 58, no. 6 (2016): 1–6. http://dx.doi.org/10.4102/safp.v58i6.4609.

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Background: Meprobamate is a constituent of various combination analgesics in South Africa. Due to the lack of recent literature on the prescribing patterns of combination analgesics containing meprobamate and in the light of its possible higher re-scheduling, this study was conducted. The primary aim was to establish the extent of meprobamate-containing combination analgesic prescribing using a prescription claims database.Methods: A retrospective, cross-sectional drug utilisation study was conducted on prescription data of a medical insurance scheme administrator in South Africa for 2011.Res
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Manore, Melinda M. "Dietary Supplements for Improving Body Composition and Reducing Body Weight: Where Is the Evidence?" International Journal of Sport Nutrition and Exercise Metabolism 22, no. 2 (2012): 139–54. http://dx.doi.org/10.1123/ijsnem.22.2.139.

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Weight-loss supplements typically fall into 1 of 4 categories depending on their hypothesized mechanism of action: products that block the absorption of fat or carbohydrate, stimulants that increase thermogenesis, products that change metabolism and improve body composition, and products that suppress appetite or give a sense of fullness. Each category is reviewed, and an overview of the current science related to their effectiveness is presented. While some weight-loss supplements produce modest effects (<2 kg weight loss), many have either no or few randomized clinical trials examining th
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Diel, Friedhelm, Friedhelm Diel, Roman Khanferyan, and Roman Khanferyan. "Sports and energy drinks." Foods and Raw Materials 6, no. 2 (2018): 379–91. http://dx.doi.org/10.21603/2308-4057-2018-2-379-391.

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Presently, sports and energy drinks are widely spread not only among athletes, but also among ordinary people of different ages. The purpose of these beverages is to effectively compensate for the loss of water, energy and electrolytes in the human body before or after some exhausting activities. A questionnaire survey on energy drinks conducted in all eight federal districts of the Russian Federation shows that the younger groups of the Russian population (aged 12–17 and 18–30) drink tonic beverages more often than the older groups (aged 31–45 and 45–60). Further, a recent rise in unreasonabl
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