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Journal articles on the topic 'Caffeine metabolism rate'

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1

Lader, Malcolm, Claire Cardwell, Philip Shine, and Nigel Scott. "Caffeine withdrawal symptoms and rate of metabolism." Journal of Psychopharmacology 10, no. 2 (1996): 110–18. http://dx.doi.org/10.1177/026988119601000205.

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2

Ashihara, Hiroshi, Hisayo Shimizu, Yoshiyuki Takeda, Takeo Suzuki, Fiona M. Gillies, and Alan Crozier. "Caffeine Metabolism in High and Low Caffeine Containing Cultivars of Camellia sinensis." Zeitschrift für Naturforschung C 50, no. 9-10 (1995): 602–7. http://dx.doi.org/10.1515/znc-1995-9-1002.

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Abstract The metabolism of [8-14C ]adenine and [2-14C]caffeine was examined in leaf segments from flush shoots of tea cultivars with high and low caffeine content. The caffeine biosynthesis pathway from AMP via theobromine was operative in both high and low caffeine containing cultivars. There was a m ore rapid rate of caffeine biosynthesis from [8-14C ]adenine in the high caffeine cultivars while the rate of degradation of both adenine nucleotides and caffeine into CO2 was greatest in cultivars with a low endogenous caffeine content. Cell-free p reparations from tea shoots contained an N-meth
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Vaughan, Roger A., Randi Garcia-Smith, Marco Bisoffi, Kristina A. Trujillo, and Carole A. Conn. "Effects of Caffeine on Metabolism and Mitochondria Biogenesis in Rhabdomyosarcoma Cells Compared with 2,4-Dinitrophenol." Nutrition and Metabolic Insights 5 (January 2012): NMI.S10233. http://dx.doi.org/10.4137/nmi.s10233.

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Purpose This work investigated if treatment with caffeine or 2,4-dinitrophenol (DNP) induce expression of peroxisome proliferator-activated receptor coactivator 1 alpha (PGC-1α) and increase both mitochondrial biosynthesis and metabolism in skeletal muscle. Methods Human rhabdomyosarcoma cells were treated with either ethanol control (0.1% final concentration) caffeine, or DNP at 250 or 500 μM for 16 or 24 hours. PGC-1α RNA levels were determined using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). PGC-1α protein and mitochondrial content was determined using flow cyto
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4

Bracco, D., J. M. Ferrarra, M. J. Arnaud, E. Jequier, and Y. Schutz. "Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women." American Journal of Physiology-Endocrinology and Metabolism 269, no. 4 (1995): E671—E678. http://dx.doi.org/10.1152/ajpendo.1995.269.4.e671.

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The magnitude of coffee-induced thermogenesis and the influence of coffee ingestion on substrate oxidation were investigated in 10 lean and 10 obese women, over two 24-h periods in a respiratory chamber. On one occasion the subjects consumed caffeinated coffee and on the other occasion, decaffeinated coffee. The magnitude of thermogenesis was smaller in obese (4.9 +/- 2.0%) than in lean subjects (7.6 +/- 1.3%). The thermogeneic response to caffeine was prolonged during the night in lean women only. The coffee-induced stimulation of energy expenditure was mediated by a concomitant increase in l
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5

Fenster, L., C. Quale, R. A. Hiatt, M. Wilson, G. C. Windham, and N. L. Benowitz. "Rate of Caffeine Metabolism and Risk of Spontaneous Abortion." American Journal of Epidemiology 147, no. 5 (1998): 503–10. http://dx.doi.org/10.1093/oxfordjournals.aje.a009477.

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6

Masi, Camilla, Caterina Dinnella, Nicola Pirastu, John Prescott, and Erminio Monteleone. "Caffeine metabolism rate influences coffee perception, preferences and intake." Food Quality and Preference 53 (October 2016): 97–104. http://dx.doi.org/10.1016/j.foodqual.2016.06.002.

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7

Wu, Shou En, and Wei-Liang Chen. "Exploring the Association between Urine Caffeine Metabolites and Urine Flow Rate: A Cross-Sectional Study." Nutrients 12, no. 9 (2020): 2803. http://dx.doi.org/10.3390/nu12092803.

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Examination of urine excretion of caffeine metabolites has been a simple but common way to determine the metabolism and effect of caffeine, but the relationship between urinary metabolites and urine flow rate is less discussed. To explore the association between urinary caffeine metabolite levels and urine flow rate, 1571 participants from the National Health and Nutrition Examination Survey (NHANES) 2011–2012 were enrolled in this study. We examined the association between urinary caffeine metabolites and urine flow rate with linear regression models. Separate models were constructed for male
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8

Brown, Christopher R., Peyton Jacob III, Margaret Wilson, and Neal L. Benowitz. "Changes in rate and pattern of caffeine metabolism after cigarette abstinence." Clinical Pharmacology and Therapeutics 43, no. 5 (1988): 488–91. http://dx.doi.org/10.1038/clpt.1988.63.

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9

Pascua, Stephanie M., Gabrielle E. McGahey, Ning Ma, Justin J. Wang, and Michelle A. Digman. "Caffeine and Cisplatin Effectively Targets the Metabolism of a Triple-Negative Breast Cancer Cell Line Assessed via Phasor-FLIM." International Journal of Molecular Sciences 21, no. 7 (2020): 2443. http://dx.doi.org/10.3390/ijms21072443.

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Triple-negative tumor cells, a malignant subtype of breast cancer, lack a biologically targeted therapy. Given its DNA repair inhibiting properties, caffeine has been shown to enhance the effectiveness of specific tumor chemotherapies. In this work, we have investigated the effects of caffeine, cisplatin, and a combination of the two as potential treatments in energy metabolism for three cell lines, triple-negative breast cancer (MDA-MB-231), estrogen-receptor lacking breast cancer (MCF7) and breast epithelial cells (MCF10A) using a sensitive label-free approach, phasor-fluorescence lifetime i
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10

Lopes, Cátia R., Andreia Oliveira, Ingride Gaspar, et al. "Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas." Biomolecules 13, no. 1 (2023): 106. http://dx.doi.org/10.3390/biom13010106.

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Adenosine receptors mainly control synaptic function, and excessive activation of adenosine receptors may worsen the onset of many neurological disorders. Accordingly, the regular intake of moderate doses of caffeine antagonizes adenosine receptors and affords robust neuroprotection. Although caffeine intake alters brain functional connectivity and multi-omics analyses indicate that caffeine intake modifies synaptic and metabolic processes, it is unclear how caffeine intake affects behavior, synaptic plasticity and its modulation by adenosine. We now report that male mice drinking caffeinated
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Del Rio, G., R. Menozzi, G. Zizzo, A. Avogaro, P. Marrama, and A. Velardo. "Increased cardiovascular response to caffeine in perimenopausal women before and during estrogen therapy." European Journal of Endocrinology 135, no. 5 (1996): 598–603. http://dx.doi.org/10.1530/eje.0.1350598.

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Del Rio G, Menozzi R, Zizzo G, Avogaro A, Marrama P, Velardo A. Increased cardiovascular response to caffeine in perimenopausal women before and during estrogen therapy. Eur J Endocrinol 1996; 135:598–603. ISSN 0804–4643 Perimenopause and menopause may be associated with an increased risk of cardiovascular disease, so we have investigated the cardiovascular and catecholamine response to caffeine in perimenopausal women compared to young cycling premenopausal subjects. Caffeine (250 mg per os) was administered to nine perimenopausal women and nine premenopausal women. The perimenopausal women r
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12

Arciero, Paul J., and Michael J. Ormsbee. "Relationship of blood pressure, behavioral mood state, and physical activity following caffeine ingestion in younger and older women." Applied Physiology, Nutrition, and Metabolism 34, no. 4 (2009): 754–62. http://dx.doi.org/10.1139/h09-068.

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The purpose of this study was to examine the age-related differences in blood pressure, heart rate, and behavioral mood state after caffeine ingestion in younger and older women. Using a placebo-controlled, double-blind design, 10 younger (Y; 18–22 years) and 10 older (O; 50–67 years) healthy women who were moderate consumers of caffeine (self-reported mean intake: Y, 139 ± 152 mg·day–1; O, 204 ± 101 mg·day–1) were investigated. All volunteers were characterized for fasting plasma glucose, insulin, free-fatty acids and caffeine levels, body composition, cardiovascular fitness, physical activit
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Polinski, Kristen, Alexandra Purdue-Smithe, Sonia Robinson, et al. "Maternal Caffeine Intake and DNA Methylation in Newborn Cord Blood." Current Developments in Nutrition 5, Supplement_2 (2021): 802. http://dx.doi.org/10.1093/cdn/nzab046_099.

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Abstract Objectives Prior research has suggested that epigenetic mechanisms may underly associations between maternal caffeine intake and adverse childhood metabolic outcomes. We examined preconception and early pregnancy maternal caffeine exposure with DNA methylation (DNAm) patterns in the cord blood of 378 neonates. Methods DNAm was profiled by the Infinium MethylationEPIC BeadChip in women enrolled in the EAGeR Trial. Maternal serum was collected 1–2 cycles preconception and at 8 weeks gestation as was self-reported caffeinated beverage intake through standardized questionnaires or daily d
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Dumont, Larry J., Swaroopa Yerrabothala, Gregory J. Tsongalis, Xiaoyun Fu, James C. Zimring, and John Roback. "Correlation Between Red Blood Cell Survival and Cytochrome P450 1A2 Enzyme Activity." Blood 122, no. 21 (2013): 3658. http://dx.doi.org/10.1182/blood.v122.21.3658.3658.

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Abstract Background Autologous red blood cell (RBC) 24h recovery in healthy volunteers is known to be highly variable between subjects, but repeatable within subjects. We previously performed metabolic screening on 2 subjects (HR) with consistently high historical 24h recoveries (85%, 88%) and 2 subjects (LR) with lower recoveries (74%, 74%). We observed that the HR subjects had lower RBC caffeine levels than the grand average for the study, while LR subjects had higher levels. Because these differences were not explained by the subjects’ self-reported caffeine consumption, we hypothesized tha
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15

Packard, P. T., and R. R. Recker. "Caffeine does not affect the rate of gain in spine bone in young women." Osteoporosis International 6, no. 2 (1996): 149–52. http://dx.doi.org/10.1007/bf01623939.

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16

Arnanda, Bramita Beta, Sri Suparwitri, and Pinandi Sri Pudyani. "Effect of caffeine in chocolate (Theobroma cacao) on the alveolar bone mineral density in guinea pigs (Cavia cobaya) with orthodontic tooth movement." Dental Journal (Majalah Kedokteran Gigi) 53, no. 3 (2020): 164. http://dx.doi.org/10.20473/j.djmkg.v53.i3.p164-169.

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Background: The benefits of chocolate have attracted significant attention from clinicians, especially the active compound of caffeine on bone metabolism. The bone density significantly affected the rate of tooth movement. Purpose: This study aims to analyse the effect of the dose and the duration of caffeine consumption in chocolate on alveolar bone mineral density in orthodontic tooth movement. Methods: Forty-eight male guinea pigs (Cavia cobaya) aged between 3-4 months and weighing 300-350 grams were divided into four groups (group A control, group B caffeine dose of 2.3 mg, group C caffein
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Suvi, Silva, Saima Timpmann, Maria Tamm, Martin Aedma, Kairi Kreegipuu, and Vahur Ööpik. "Effects of caffeine on endurance capacity and psychological state in young females and males exercising in the heat." Applied Physiology, Nutrition, and Metabolism 42, no. 1 (2017): 68–76. http://dx.doi.org/10.1139/apnm-2016-0206.

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Acute caffeine ingestion is considered effective in improving endurance capacity and psychological state. However, current knowledge is based on the findings of studies that have been conducted on male subjects mainly in temperate environmental conditions, but some physiological and psychological effects of caffeine differ between the sexes. The purpose of this study was to compare the physical performance and psychological effects of caffeine in young women and men exercising in the heat. Thirteen male and 10 female students completed 2 constant-load walks (60% of thermoneutral peak oxygen co
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18

Bottoms, L., H. Hurst, A. Scriven, et al. "The effect of caffeine mouth rinse on self-paced cycling performance." Comparative Exercise Physiology 10, no. 4 (2014): 239–45. http://dx.doi.org/10.3920/cep140015.

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The aim of the study was to determine whether caffeine mouth rinse would improve 30 min self-paced cycling trial. Twelve healthy active males (age 20.5±0.7 years, mass 87.4±18.3 kg) volunteered for the study. They attended the laboratory on 3 separate occasions performing a 30 min self-paced cycling trial. On one occasion water was given as a mouth rinse for 5 s (PLA), on another occasion a 6.4% maltodextrin (CHO) solution was given for 5 s and finally a caffeine solution (containing 32 mg of caffeine dissolved in 125 ml water; CAF) was given for 5 s. Distance cycled, heart rate, ratings of pe
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Marinda Sukmawanta, Shafara Najla, Dyah Ratna Wulan, Kristina Widjajanti, Noor Isnaini Azkiya, and Yanty Maryanty. "Ekstrak Kafein sebagai Inhibitor Korosi Alami pada Logam Aluminium dalam Media Larutan Asam Sulfat dan Biosolar." Jurnal Riset Kimia 13, no. 1 (2022): 68–75. http://dx.doi.org/10.25077/jrk.v13i1.488.

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This research, the caffeine extract of arabica coffee beans, cacao beans, and black tea leaves will be tested as a corrosion inhibitor on aluminium in an acidic environment and in biodiesel containing acid. This condition resembles the metabolism of microorganisms in biodiesel which produces H2SO4 as one of the causes of corrosion. Arabica coffee, cacao beans and black tea are natural organic ingredients containing caffeine which can inhibit corrosion. In the maceration process used a variable ratio of 70% ethanol solvent with organic matter, namely 225 grams of organic matter with 450 grams o
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20

Snowdowne, K. W. "Subcontracture depolarizations increase sarcoplasmic ionized calcium in frog skeletal muscle." American Journal of Physiology-Cell Physiology 248, no. 5 (1985): C520—C526. http://dx.doi.org/10.1152/ajpcell.1985.248.5.c520.

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The hypothesis that the sarcoplasmic concentration of ionized calcium (Cai) of frog skeletal muscle may control its rate of metabolism was examined by monitoring the changes in Cai due to perturbations that are known, from the work of previous investigators, to alter the rate of metabolism. Cai was measured with aequorin, which was microinjected into isolated fibers in sufficient quantity to detect basal Cai. When these fibers were exposed to 5-18 mM KCl, 75 mM RbCl2, or 100 mM CsCl2, there was an increase in the aequorin signal. The potassium-evoked increase in the aequorin signal was diminis
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Beaven, C. Martyn, Peter Maulder, Adrian Pooley, Liam Kilduff, and Christian Cook. "Effects of caffeine and carbohydrate mouth rinses on repeated sprint performance." Applied Physiology, Nutrition, and Metabolism 38, no. 6 (2013): 633–37. http://dx.doi.org/10.1139/apnm-2012-0333.

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Our purpose was to examine the effectiveness of carbohydrate and caffeine mouth rinses in enhancing repeated sprint ability. Previously, studies have shown that a carbohydrate mouth rinse (without ingestion) has beneficial effects on endurance performance that are related to changes in brain activity. Caffeine ingestion has also demonstrated positive effects on sprint performance. However, the effects of carbohydrate or caffeine mouth rinses on intermittent sprints have not been examined previously. Twelve males performed 5 × 6-s sprints interspersed with 24 s of active recovery on a cycle erg
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Lopes-Silva, João Paulo, Jonatas Ferreira da Silva Santos, and Emerson Franchini. "Can caffeine supplementation reverse the effect of time of day on repeated-sprint exercise performance?" Applied Physiology, Nutrition, and Metabolism 44, no. 2 (2019): 187–93. http://dx.doi.org/10.1139/apnm-2018-0373.

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The aim of this study was to evaluate if caffeine can reduce the negative influence of diurnal variations on repeated-sprint performance, in addition to investigating if caffeine in the afternoon would potentiate performance compared with the morning. Thirteen physically active men took part in this randomized, double-blind, placebo-controlled and crossover study. All participants underwent a repeated-sprint ability test (10 × 6 s cycle sprints, with 30 s of rest) at 60 min after ingestion of either 5 mg·kg−1 or placebo under 4 different conditions: morning with caffeine ingestion, morning wit
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Delleli, Slaheddine, Ibrahim Ouergui, Hamdi Messaoudi, et al. "Acute Effects of Caffeine Supplementation on Physical Performance, Physiological Responses, Perceived Exertion, and Technical-Tactical Skills in Combat Sports: A Systematic Review and Meta-Analysis." Nutrients 14, no. 14 (2022): 2996. http://dx.doi.org/10.3390/nu14142996.

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Although the effects of caffeine supplementation on combat sports performance have been extensively investigated, there is currently no consensus regarding its ergogenic benefits.This systematic review with meta-analysis aimed to summarize the studies investigating the effects of caffeine supplementation on different aspects of performance in combat sports and to quantitatively analyze the results of these studies to better understand the ergogenic effect of caffeine on combat sports outcomes. A systematic search for randomized placebo-controlled studies investigating the effects of caffeine s
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Moschino, Laura, Sanja Zivanovic, Caroline Hartley, Daniele Trevisanuto, Eugenio Baraldi, and Charles Christoph Roehr. "Caffeine in preterm infants: where are we in 2020?" ERJ Open Research 6, no. 1 (2020): 00330–2019. http://dx.doi.org/10.1183/23120541.00330-2019.

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The incidence of preterm birth is increasing, leading to a growing population with potential long-term pulmonary complications. Apnoea of prematurity (AOP) is one of the major challenges when treating preterm infants; it can lead to respiratory failure and the need for mechanical ventilation. Ventilating preterm infants can be associated with severe negative pulmonary and extrapulmonary outcomes, such as bronchopulmonary dysplasia (BPD), severe neurological impairment and death. Therefore, international guidelines favour non-invasive respiratory support. Strategies to improve the success rate
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Zhang, Meijia, Haiyan Hong, Bo Zhou, et al. "The expression of atrial natriuretic peptide in the oviduct and its functions in pig spermatozoa." Journal of Endocrinology 189, no. 3 (2006): 493–507. http://dx.doi.org/10.1677/joe.1.06483.

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Locally synthesized atrial natriuretic peptide (ANP) and its receptors have been found in reproductive tissues of various mammals, and play an important role in the acrosome reaction of human sperm. The objective of the present study was to examine the expression of ANP and its receptors in pig spermatozoa and oviduct, and the effect of ANP on pig spermatozoa function. The expression of ANP and its receptors was analyzed by RT-PCR. Only natriuretic peptide receptors-A (NPRA) mRNA was detected in fresh sperm. While the levels of natriuretic peptide receptors-C (NPRC) mRNA were low with no obvio
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Antonov, A. G., V. D. Vybornov, M. Y. Balandin, et al. "Practical guidelines for standardising the measurement of resting metabolism by indirect calorimetry: a literature review." Sports medicine: research and practice 12, no. 2 (2022): 96–104. http://dx.doi.org/10.47529/2223-2524.2022.2.11.

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Accurate resting metabolic rate readings are essential for dietary planning and body composition monitoring not only for healthy individuals but also for athletes. A number of factors can alter resting metabolic rate during its measurement by indirect calorimetry. The methodology used may affect the results of the study. A clear standardisation of this procedure is needed to obtain the most accurate results.Purpose: To review the literature to determine the optimal subject condition and methodology for the resting metabolism measurement procedure using indirect calorimetry.Materials and method
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Jackson, Joshua G., and Stanley A. Thayer. "Mitochondrial Modulation of Ca2+-Induced Ca2+-Release in Rat Sensory Neurons." Journal of Neurophysiology 96, no. 3 (2006): 1093–104. http://dx.doi.org/10.1152/jn.00283.2006.

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Ca2+-induced Ca2+-release (CICR) from ryanodine-sensitive Ca2+ stores provides a mechanism to amplify and propagate a transient increase in intracellular calcium concentration ([Ca2+]i). A subset of rat dorsal root ganglion neurons in culture exhibited regenerative CICR when sensitized by caffeine. [Ca2+]i oscillated in the maintained presence of 5 mM caffeine and 25 mM K+. Here, CICR oscillations were used to study the complex interplay between Ca2+ regulatory mechanisms at the cellular level. Oscillations depended on Ca2+ uptake and release from the endoplasmic reticulum (ER) and Ca2+ influx
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28

Júdice, Pedro B., João P. Magalhães, Diana A. Santos, et al. "A moderate dose of caffeine ingestion does not change energy expenditure but decreases sleep time in physically active males: a double-blind randomized controlled trial." Applied Physiology, Nutrition, and Metabolism 38, no. 1 (2013): 49–56. http://dx.doi.org/10.1139/apnm-2012-0145.

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Research on the effect of caffeine on energy expenditure (EE), physical activity (PA), and total sleep time (TST) during free-living conditions using objective measures is scarce. We aimed to determine the impact of a moderate dose of caffeine on TST, resting EE (REE), physical activity EE (PAEE), total EE (TEE), and daily time spent in sedentary, light, moderate, and vigorous intensity activities in a 4-day period and the acute effects on heart rate (HR) and EE in physically active males. Using a double-blind crossover trial (ClinicalTrials.gov ID: NCT01477294) with two conditions (4 days eac
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Masodsai, Kunanya, Thanachai Sahaschot, and Rungchai Chaunchaiyakul. "Cardiorespiratory, Metabolic, and Performance Changes from the Effects of Creatine and Caffeine Supplementations in Glucose–Electrolyte-Based Sports Drinks: A Double-Blind, Placebo-Controlled Study." Sports 11, no. 1 (2022): 4. http://dx.doi.org/10.3390/sports11010004.

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The purpose of this study is to investigate the additive effects of creatine and caffeine on changes in the cardiorespiratory system, metabolism, and performance of soccer players. Seventeen male soccer players randomly ingested three sports drinks comprising the following: glucose–electrolyte-based (Drink 1, control; D1), glucose–electrolyte-based drink + 5 g creatine (Drink 2; D2), and glucose–electrolyte-based drink + 5 g creatine + 35 mg caffeine (Drink 3; D3) during a 15 min recovery period after the modified Loughborough Intermittent Shuttle Test (LIST) on a standard outdoor soccer field
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Oskarsson, Johanna, and Kerry McGawley. "No individual or combined effects of caffeine and beetroot-juice supplementation during submaximal or maximal running." Applied Physiology, Nutrition, and Metabolism 43, no. 7 (2018): 697–703. http://dx.doi.org/10.1139/apnm-2017-0547.

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Dietary supplements such as caffeine and beetroot juice are used by athletes in an attempt to optimize performance and therefore gain an advantage in competition. The aim of this study was to investigate the individual and combined effects of caffeine and beetroot-juice supplementation during submaximal and maximal treadmill running. Seven males (maximal oxygen uptake: 59.0 ± 2.9 mL·kg–1·min–1) and 2 females (maximal oxygen uptake: 53.1 ± 11.4 mL·kg–1·min–1) performed a preliminary trial followed by 4 experimental test sessions. Each test session consisted of two 5-min submaximal running bouts
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Kennedy, Michael D., Ashley V. Galloway, Leanne J. Dickau, and Megan K. Hudson. "The cumulative effect of coffee and a mental stress task on heart rate, blood pressure, and mental alertness is similar in caffeine-naïve and caffeine-habituated females." Nutrition Research 28, no. 9 (2008): 609–14. http://dx.doi.org/10.1016/j.nutres.2008.06.003.

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Richardson, T., A. Rozkovec, P. Thomas, J. Ryder, C. Meckes, and D. Kerr. "Influence of Caffeine on Heart Rate Variability in Patients With Long-Standing Type 1 Diabetes." Diabetes Care 27, no. 5 (2004): 1127–31. http://dx.doi.org/10.2337/diacare.27.5.1127.

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Talanian, Jason L., and Lawrence L. Spriet. "Low and moderate doses of caffeine late in exercise improve performance in trained cyclists." Applied Physiology, Nutrition, and Metabolism 41, no. 8 (2016): 850–55. http://dx.doi.org/10.1139/apnm-2016-0053.

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The aim of the present study was to assess if low and moderate doses of caffeine delivered in a carbohydrate-electrolyte solution (CES) late in exercise improved time-trial (TT) performance. Fifteen (11 male, 4 female) cyclists (age, 22.5 ± 0.9 years; body mass, 69.3 ± 2.6 kg; peak oxygen consumption, 64.6 ± 1.9 mL·min−1·kg−1) completed 4 double-blinded randomized trials. Subjects completed 120 min of cycling at ∼60% peak oxygen consumption with 5 interspersed 120-s intervals at ∼82% peak oxygen consumption, immediately followed by 40-s intervals at 50 W. Following 80 min of cycling, subjects
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Turley, Kenneth R., Travis DeSisso, and Jonathan W. Gerst. "Effects of Caffeine on Physiological Responses to Exercise: Boys versus Men." Pediatric Exercise Science 19, no. 4 (2007): 481–92. http://dx.doi.org/10.1123/pes.19.4.481.

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We compared the influence of caffeine on physiological responses to exercise between boys and men. Fifty-two participants (26 boys and 26 men) participated in a double blind, randomized, double crossover study. Each participant received the caffeinated (5 mg/kg) drink (CAF) and placebo (PL) twice each on 4 separate days. One hour after drink consumption preexercise heart rate (HR) and blood pressure (BP) were measured. Then while the participants rode stationary cycle ergometers at two different exercise intensities, HR, BP, and oxygen consumption (VO2) were measured. Blood pressure was not si
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Green, James M., Alyssa Olenick, Caroline Eastep, and Lee Winchester. "Caffeine effects on velocity selection and physiological responses during RPE production." Applied Physiology, Nutrition, and Metabolism 41, no. 10 (2016): 1077–82. http://dx.doi.org/10.1139/apnm-2016-0098.

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Caffeine (CAF) blunts estimated ratings of perceived exertion (RPE) but the effects on RPE production are unclear. This study examined effects of acute caffeine ingestion during treadmill exercise where participants exercised at prescribed RPE 4 and 7. Recreational runners (maximal oxygen consumption = 51.4 ± 9.8 mL·kg−1·min−1) (n = 16) completed a maximal treadmill test followed by trials where they selected treadmill velocity (VEL) (1% grade) to produce RPE 4 and RPE 7 (10 min each). RPE production trials followed CAF (6 mg·kg−1) or placebo (PLA) (counterbalanced) ingestion. Participants wer
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Andreazzi, Ana Eliza, Sabrina Grassiolli, Paula Beatriz Marangon, et al. "Impaired Sympathoadrenal Axis Function Contributes to Enhanced Insulin Secretion in Prediabetic Obese Rats." Experimental Diabetes Research 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/947917.

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The involvement of sympathoadrenal axis activity in obesity onset was investigated using the experimental model of treating neonatal rats with monosodium L-glutamate. To access general sympathetic nervous system activity, we recorded the firing rates of sympathetic superior cervical ganglion nerves in animals. Catecholamine content and secretion from isolated adrenal medulla were measured. Intravenous glucose tolerance test was performed, and isolated pancreatic islets were stimulated with glucose and adrenergic agonists. The nerve firing rate of obese rats was decreased compared to the rate f
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Nawaji, Tasuku, Natsumi Yamashita, Haruka Umeda, et al. "Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish." Pharmaceuticals 13, no. 12 (2020): 456. http://dx.doi.org/10.3390/ph13120456.

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Zebrafish are used widely in biomedical, toxicological, and developmental research, but information on their xenobiotic metabolism is limited. Here, we characterized the expression of 14 xenobiotic cytochrome P450 (CYP) subtypes in whole embryos and larvae of zebrafish (4 to 144 h post-fertilization (hpf)) and the metabolic activities of several representative human CYP substrates. The 14 CYPs showed various changes in expression patterns during development. Many CYP transcripts abruptly increased at about 96 hpf, when the hepatic outgrowth progresses; however, the expression of some cyp1s (1b
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Vicente-Salar, Néstor, Encarna Fuster-Muñoz, and Alejandro Martínez-Rodríguez. "Nutritional Ergogenic Aids in Combat Sports: A Systematic Review and Meta-Analysis." Nutrients 14, no. 13 (2022): 2588. http://dx.doi.org/10.3390/nu14132588.

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Nutritional ergogenic aids (NEAs) are substances included within the group of sports supplements. Although they are widely consumed by athletes, evidence-based analysis is required to support training outcomes or competitive performance in specific disciplines. Combat sports have a predominant use of anaerobic metabolism as a source of energy, reaching peak exertion or sustained effort for very short periods of time. In this context, the use of certain NEAs could help athletes to improve their performance in those specific combat skills (i.e., the number of attacks, throws and hits; jump heigh
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Basrai, Maryam, Anna Schweinlin, Juliane Menzel, et al. "Energy Drinks Induce Acute Cardiovascular and Metabolic Changes Pointing to Potential Risks for Young Adults: A Randomized Controlled Trial." Journal of Nutrition 149, no. 3 (2019): 441–50. http://dx.doi.org/10.1093/jn/nxy303.

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ABSTRACTBackgroundCase reports suggest a link between energy drinks (EDs) and adverse events, including deaths.ObjectivesWe examined cardiovascular and metabolic effects of EDs and mixtures providing relevant ingredients of EDs compared to a similarly composed control product (CP) without these components.MethodsThis randomized, crossover trial comprised 38 adults (19 women, mean BMI 23 kg/m2, mean age 22 y). We examined effects of a single administration of a commercial ED, the CP, and the CP supplemented with major ED-ingredients at the same concentrations as in the ED. The study products we
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Rebollo-Hernanz, Miguel, Yolanda Aguilera, Maria A. Martin-Cabrejas та Elvira Gonzalez de Mejia. "Bioactives From Coffee By-Products Stimulate Liver Metabolism and Mitochondrial Bioenergetics via AMPK/PGC-1α/Nrf2 and IRS/AKT/GLUT2 Pathways In Vitro". Current Developments in Nutrition 6, Supplement_1 (2022): 332. http://dx.doi.org/10.1093/cdn/nzac053.073.

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Abstract Objectives This study aimed to investigate the effect of the main bioactive compounds from the coffee silverskin and coffee husk on hepatic lipid and glucose metabolism and mitochondrial bioenergetics using an in vitro model mimicking non-alcoholic fatty liver disease. Methods HepG2 cells were treated with 50 μmol L−1 caffeine, chlorogenic, caffeic, protocatechuic, or gallic acids, or kaempferol, or the aqueous extracts from the coffee silverskin (CSE, 100 μg mL−1) or the coffee husk (CHE, 100 μg mL−1) in the presence of palmitic acid (500 μmol L−1). Cell metabolism biomarkers were as
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Andrade-Souza, Victor Amorim, Romulo Bertuzzi, Gustavo Gomes de Araujo, David Bishop, and Adriano Eduardo Lima-Silva. "Effects of isolated or combined carbohydrate and caffeine supplementation between 2 daily training sessions on soccer performance." Applied Physiology, Nutrition, and Metabolism 40, no. 5 (2015): 457–63. http://dx.doi.org/10.1139/apnm-2014-0268.

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This study aimed to investigate whether isolated or combined carbohydrate (CHO) and caffeine (CAF) supplementation have beneficial effects on performance during soccer-related tests performed after a previous training session. Eleven male, amateur soccer players completed 4 trials in a randomized, double-blind, and crossover design. In the morning, participants performed the Loughborough Intermittent Shuttle Test (LIST). Then, participants ingested (i) 1.2 g·kg−1 body mass·h−1 CHO in a 20% CHO solution immediately after and 1, 2, and 3 h after the LIST; (ii) CAF (6 mg·kg−1 body mass) 3 h after
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Freerksen, D. L., N. A. Schroedl, G. V. Johnson, and C. R. Hartzell. "Increased aerobic glucose oxidation by cAMP in cultured regenerated skeletal myotubes." American Journal of Physiology-Cell Physiology 250, no. 5 (1986): C713—C719. http://dx.doi.org/10.1152/ajpcell.1986.250.5.c713.

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Previous studies of embryonic rat skeletal muscle cultures suggested that there was a correlation between intracellular adenosine 3',5'-cyclic monophosphate (cAMP) concentration and activities of enzymes of oxidative energy metabolism. We investigated the ability of agents that elevate intracellular cAMP by three different mechanisms (activation of adenylate cyclase, inhibition of phosphodiesterase, and analogues) to alter not only the activities of 11 glycolytic and mitochondrial enzymes but also the rate of flux through aerobic glucose oxidation in intact myotubes derived from regenerating r
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Porto, Andrey Alves, Cicero Jonas R. Benjamim, Luana Almeida Gonzaga, et al. "Caffeine intake and its influences on heart rate variability recovery in healthy active adults after exercise: A systematic review and meta-analysis." Nutrition, Metabolism and Cardiovascular Diseases 32, no. 5 (2022): 1071–82. http://dx.doi.org/10.1016/j.numecd.2022.01.015.

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Mahdavi, Sara, Paolo Palatini, and Ahmed El-Sohemy. "CYP1A2 Genetic Variation, Coffee Intake, and Kidney Dysfunction." JAMA Network Open 6, no. 1 (2023): e2247868. http://dx.doi.org/10.1001/jamanetworkopen.2022.47868.

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ImportanceCaffeine is detoxified by cytochrome P450 1A2 (CYP1A2), and genetic variation in CYP1A2 impacts the rate of caffeine clearance. Factors that may modify the association between coffee intake and kidney disease remain unclear.ObjectiveTo assess whether CYP1A2 genotype modifies the association between coffee intake and kidney dysfunction.Design, Setting, and ParticipantsThe Hypertension and Ambulatory Recording Venetia Study (HARVEST) was a prospective cohort study of individuals with stage 1 hypertension in Italy; HARVEST began on April 1, 1990, and follow-up is ongoing. The current st
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Lindqvist, Anders, Karl Dreja, Karl Swärd, and Per Hellstrand. "Effects of oxygen tension on energetics of cultured vascular smooth muscle." American Journal of Physiology-Heart and Circulatory Physiology 283, no. 1 (2002): H110—H117. http://dx.doi.org/10.1152/ajpheart.00040.2001.

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Chronic hypoxia is a clinically important condition known to cause vascular abnormalities. To investigate the cellular mechanisms involved, we kept rings of a rat tail artery for 4 days in hypoxic culture (HC) or normoxic culture (NC) (Po 2 = 14 vs. 110 mmHg) and then measured contractility, oxygen consumption ( J o2 ), and lactate production ( J lac) in oxygenated medium. Compared with fresh rings, basal ATP turnover ( J ATP) was decreased in HC, but not in NC, with a shift from oxidative toward glycolytic metabolism. J o2 during mitochondrial uncoupling was reduced by HC but not by NC. Glyco
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Devenney, Simon, Shane Mangan, Marcus Shortall, and Kieran Collins. "Effects of carbohydrate mouth rinse and caffeine on high-intensity interval running in a fed state." Applied Physiology, Nutrition, and Metabolism 43, no. 5 (2018): 517–21. http://dx.doi.org/10.1139/apnm-2017-0458.

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The current study aims to identify if mouth rinsing with a 6% carbohydrate mouth-rinse (CMR) solution and mouth rinsing and ingestion of caffeine (CMR+CAFF) can affect exercise performance during steady-state (SS) running and high-intensity intervals (HIIT) in comparison with a 0% control solution (PLA) when in a fed state. Eight recreationally trained males completed 3 trials (CMR, CMR+CAFF, and PLA) of 45 min SS running and an HIIT protocol (90% peak treadmill velocity) until fatigue in a double blinded, repeated-measures study. Participants ingested a capsule of either CAFF or PLA before an
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Jaffe, Craig A., D. Kim Turgeon, Kenneth Lown, Roberta Demott-Friberg, and Paul B. Watkins. "Growth hormone secretion pattern is an independent regulator of growth hormone actions in humans." American Journal of Physiology-Endocrinology and Metabolism 283, no. 5 (2002): E1008—E1015. http://dx.doi.org/10.1152/ajpendo.00513.2001.

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The importance of gender-specific growth hormone (GH) secretion pattern in the regulation of growth and metabolism has been demonstrated clearly in rodents. We recently showed that GH secretion in humans is also sexually dimorphic. Whether GH secretion pattern regulates the metabolic effects of GH in humans is largely unknown. To address this question, we administered the same daily intravenous dose of GH (0.5 mg · m−2 · day−1) for 8 days in different patterns to nine GH-deficient adults. Each subject was studied on four occasions: protocol 1 (no treatment), protocol 2 (80% daily dose at 0100
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Bantu, Sravani, Shirisha R. Vallepu, Mouna Gunda, and Vaishali Thudi. "Incidental Pheochromocytoma: Silent but Violent." Journal of the Endocrine Society 5, Supplement_1 (2021): A137—A138. http://dx.doi.org/10.1210/jendso/bvab048.277.

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Abstract Background: Pheochromocytoma is a rare catecholamine secreting neuroendocrine tumor. It arises from the chromaffin cells of adrenal medulla. It is diagnosed in 5–6.5% of adrenal incidentalomas which is not common. The usual clinical presentation includes the classic triad of sweating, headache and tachycardia. However, asymptomatic cases are seen in 8% of the patients with pheochromocytoma. We present a clinically asymptomatic patient diagnosed during work up of adrenal incidentaloma. The possible etiology for silent presentation includes one of the following:(i) Presence of a smaller
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Nesbeth, Paula-Dene, Veronika Fedirko, Dean Jones, et al. "An Untargeted Metabolomic Study of the Effects of Vitamin D and/or Calcium Supplementation Among Individuals at High Risk for Colorectal Neoplasms." Current Developments in Nutrition 4, Supplement_2 (2020): 343. http://dx.doi.org/10.1093/cdn/nzaa044_042.

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Abstract Objectives To obtain preliminary data on the independent and synergistic anti-neoplastic effects of 1-year supplementation with vitamin D3 and/or calcium on the plasma metabolome and metabolic pathways among individuals at high risk for colorectal neoplasms. Methods This study was an untargeted metabolomic analysis that used data and biosamples from a completed, large, multicenter, randomized, placebo-controlled, clinical trial of vitamin D3 (1000 IU/d) and/or calcium (1200 mg/d via calcium carbonate) for preventing colorectal adenoma recurrence. High resolution liquid chromatography-
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Yuan, Shuai, and Susanna C. Larsson. "An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study." Diabetologia 63, no. 11 (2020): 2359–71. http://dx.doi.org/10.1007/s00125-020-05253-x.

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Abstract Aims/hypothesis The aim of this study was to use Mendelian randomisation (MR) to identify the causal risk factors for type 2 diabetes. Methods We first conducted a review of meta-analyses and review articles to pinpoint possible risk factors for type 2 diabetes. Around 170 possible risk factors were identified of which 97 risk factors with available genetic instrumental variables were included in MR analyses. To reveal more risk factors that were not included in our MR analyses, we conducted a review of published MR studies of type 2 diabetes. For our MR analyses, we used summary-leve
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