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Dissertations / Theses on the topic 'Cag Type IV Secretion System'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Pham, Kieu Thuy [Verfasser], and Wolfgang [Akademischer Betreuer] Fischer. "Functional characterization of the Helicobacter pylori Cag Type IV secretion system components CagH, CagI and CagL / Kieu Thuy Pham ; Betreuer: Wolfgang Fischer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1124780033/34.

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2

Jiménez, Soto Luisa Fernanda. "Studies on the function of the Cag Type IV Secretion System of Helicobacter pylori with integrin Beta1." kostenfrei, 2009. http://edoc.ub.uni-muenchen.de/10659/.

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3

Jimenez, Soto Luisa Fernanda. "Studies on the function of the Cag Type IV Secretion System of Helicobacter pylori with integrin Beta1." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-106597.

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4

Zeitler, Anna Friederike [Verfasser], and Rainer [Akademischer Betreuer] Haas. "Identification of cellular mechanisms interfering with the Helicobacter pylori cag type IV secretion system / Anna Friederike Zeitler ; Betreuer: Rainer Haas." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1230754679/34.

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5

Lopez-Lozano, Nina. "Caractérisation structurale de nanomachines bactériennes impliquées dans l'adaptabilité et la virulence." Electronic Thesis or Diss., Bordeaux, 2023. http://www.theses.fr/2023BORD0482.

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Cette thèse est divisée en deux thématiques.La première porte sur le système de Sécrétion de TypeIV cag (cag-SST4) d’Helicobacter pylori. Il s’agit d’une machinerie de sécrétion complexe enchâssée dans l’enveloppe cellulaire de la bactérie, lui permettant d’injecter l’oncoprotéine CagA dans les cellules épithéliales gastriques humaines. Cette toxine est considérée comme un facteur de virulence majeur d’H. pylori. Elle interagit avec des protéines de l’hôte, perturbant la signalisation cellulaire et entraînant des modifications pouvant favoriser le développement de maladies gastrointestinales,

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6

Bauer, Bianca. "Molekulare Charakterisierung von Typ IV Sekretionssytem-spezifischen Wirtszellantworten und bakteriellen Virulenzfaktoren des humanen Magenpathogens Helicobacter pylori." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16045.

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Das humane Magenpathogen Helicobacter pylori (H. pylori) besiedelt den menschlichen Magen und kann zu der Entstehung schwerwiegender Krankheiten wie Magenkrebs und Magengeschwüren führen. Die Pathogenese ist eng mit dem bakteriellen Typ IV Sekretionssystems (T4SS) assoziiert, das die Translokation des Effektorproteins CagA in die Wirtszelle vermittelt. Bisher ist noch unbekannt, in welchem Ausmaß wirtszellspezifische Faktoren die T4SS induzierte Pathogenese beeinflussen. Dieser Aspekt wurde in dieser Arbeit durch die Analyse verschiedenster Zelllinien das erste Mal systematisch untersucht. Int

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7

Connery, Sarah. "Reconstitution and localisation studies of a type IV secretion system." Thesis, Birkbeck (University of London), 2014. http://bbktheses.da.ulcc.ac.uk/75/.

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Bacterial conjugation is the transport of a DNA molecule from a donor cell to a recipient. Since bacteria do not reproduce sexually, conjugation is a major contributor to prokaryotic genome plasticity and the spread of antibiotic resistance genes. A Type IV Secretion System (T4SS) mediates the DNA transport during conjugation. T4SSs are large macromolecular assemblies embedded in the membrane of bacteria, and are associated with pathogenesis, bacterial conjugation and natural transformation. They are a versatile family of secretion systems, who transport a wide variety of substrates, such as v

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8

Sutten, Eric Lynn. "The immunogenicity of the type IV secretion system in Anaplasma marginale." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Summer2009/e_sutten_072409.pdf.

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Thesis (M.S. in veterinary science)--Washington State University, August 2009.<br>Title from PDF title page (viewed on Aug. 7, 2009). "Department of Veterinary Microbiology and Pathology." Includes bibliographical references.

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9

Schindele, Franziska Maria [Verfasser], and Rainer [Akademischer Betreuer] Haas. "Development and application of a novel Cag type IV secretion reporter assay in Helicobacter pylori / Franziska Maria Schindele ; Betreuer: Rainer Haas." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1156173116/34.

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10

Engledow, Amanda Suzanne. "Role of type IV secretion systems in trafficking of virulence determinants of Burkholderia cenocepacia." Thesis, [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1841.

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11

Nikraftar, Sarah. "Localization of Type IV Pilin Polymerization Proteins in Clostridium perfringens." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/71742.

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Clostridium perfringens is a spore-forming anaerobic Gram-positive rod which has gliding motility through type IV Pili (TFP). Since the discovery of TFP in Gram-positive bacteria is relatively new, more studies are required to understand the mechanism and interaction of the proteins of this machinery. Moreover, the similarities between TFP and type 2 secretion system (T2SS) suggest that C. perfringens has also a T2SS. We studied the localization of TFP ATPases, PilB1, PilB2 and PilT in Bacillus subtilis to compare the localization in an organism other than C. perfringens and which lacks any

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12

Niu, Hua. "The Role of Cellular Autophagy and Type IV Secretion System in Anaplasma phagocytophilum Infection." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1211307210.

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13

Netto, Diogo dos Santos. "Development of a database for classification and analysis of type IV secretion systems." Laboratório Nacional de Computação Científica, 2008. http://www.lncc.br/tdmc/tde_busca/arquivo.php?codArquivo=198.

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The type IV secretion system can be classified as a large family of macromolecule transporters divided in three recognized sub-families involved in different bacterial functions. The major sub-family of T4SS is the conjugation system, which allows transfer of genetic material as a nucleoprotein via cell contact among bacteria. Analogously to bacterial conjugation, the T4SS can transfer genetic material from bacteria to eukaryotic cells; such is the case of T-DNA transfer of Agrobacterium tumefaciens to host plant cells. The system of effector proteins transport constitutes the second sub-famil

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14

Salomonsson, Emelie. "The role of the Type IV pili system in the virulence of Francisella tularensis." Doctoral thesis, Umeå universitet, Molekylärbiologi (Teknisk-naturvetenskaplig fakultet), 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1656.

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Francisella tularensis is a Gram-negative intracellular pathogen causing the zoonotic disease tularemia. F. tularensis can be found almost all over the world and has been recovered from several animal species, even though the natural reservoir of the bacterium and parts of its life cycle are still unknown. Humans usually get infected after handling infected animals or from bites of blood-feeding arthropod vectors. There are four subspecies of F. tularensis: the highly virulent tularensis (Type A) that causes a very aggressive form of the disease, with mortality as high as 60% if untreated, the

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15

Oliveira, Luciana Coutinho de. "Characterization of structure, dynamics, function and interactions of components from the type IV secretion system of Xanthomonas citri by solution nuclear magnetic resonance." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-15092016-084423/.

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Bacteria use specialized systems, called secretion systems, in order to translocate substrates to the environment or to other cells, or even to uptake molecules from the exterior environment. Six different secretion systems have been described in Gram-negative bacteria. The Type IV Secretion System (T4SS) is involved in translocation of virulence factors, bacterial conjugation, uptake and release of DNA, and in the secretion of antibacterial toxins. The T4SS channel corresponds to a toroidal upramolecular complex consisting of 14 repetitions of the VirB7-VirB9-VirB10 heterotrimer. This channel

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16

Sundin, Charlotta. "Type III Secretion Mediated Translocation of Effector Exoenzymes by Pseudomonas aeruginosa." Doctoral thesis, Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-174.

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17

Jacobsen, Theis. "Structure and assembly of bacterial type IV filaments unravelled by an integrative approach." Electronic Thesis or Diss., Sorbonne université, 2022. http://www.theses.fr/2022SORUS146.

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La superfamille des filaments de type IV (TFF) est un groupe de machines moléculaires localisées dans la membrane des bactéries et des archées. Ces machines associent des polymères protéiques de manière non-covalente appelés des pili, qui s’étendent depuis la cellule pour réaliser plusieurs fonctions qui ont évolué spécifiquement pour s’adapter à des organismes hôtes différents. La superfamille TFF comprend le système de sécrétion de type II (T2SS) et les pili de type IVa (T4aP). Le T2SS induit la sécrétion de substrats chez les bactéries Gram-négatives. Ces substrats sont en général des enzym

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18

Cheng, Zhihui. "Transcriptional regulators of Ehrlichia chaffeensis during intracellular development and the roles of OmpA in the bacterial infection and survival." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1227561447.

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19

Lautner, Monika. "Untersuchungen zum Aufbau, zur Funktion und zur Verbreitung von genomischen Inseln in der Gattung Legionella." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16676.

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Der Austausch von genetischem Material über horizontalen Gentransfer, stellt einen wichtigen Mechanismus in der bakteriellen Evolution dar. Legionella pneumophila Stämme codieren für verschiedene Typ IV Sekretionssysteme (T4SS) und integrative konjugative Elemente, die zur genomischen Variabilität der intrazellulären Erreger beitragen. L. pneumophila Corby codiert auf der genomischen Insel Trb-1 für ein funktionelles Konjugations- und T4ASS. Trb-1 ist innerhalb des tRNAPro Gens integriert und kann in einer chromosomalen oder zirkulären episomalen Form existieren. Zusätzlich zu den trb/tra Gene

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20

Heller, Eva Maria [Verfasser], and Lotte [Akademischer Betreuer] Sogaard-Andersen. "Biochemical characterization of the relaxase TraI, the coupling protein TraD and the hypothetical protein Yaf of the novel Type IV Secretion System from the human pathogen Neisseria gonorrhoeae / Eva-Maria Heller. Betreuer: Lotte Sogaard-Andersen." Marburg : Philipps-Universität Marburg, 2014. http://d-nb.info/105193463X/34.

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21

Borin, Paula Fernanda Lacarini. "Caracterização estrutural da proteína hipotética XACb0033 da bactéria Xanthomonas axonopodis pv. citri." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248423.

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Orientador: Ljubica Tasic<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-16T13:55:17Z (GMT). No. of bitstreams: 1 Borin_PaulaFernandaLacarini_M.pdf: 1689128 bytes, checksum: c3f8712ed17691069b7fabb711257101 (MD5) Previous issue date: 2010<br>Resumo: A Xanthomonas axonopodis pv. citri (Xac) é uma bactéria Gram-negativa que parasita plantas cítricas e é responsável pela doença conhecida como cancro cítrico, que apresenta grande importância econômica em todo mundo. Acredita-se que a infecção da célula hospedeira ocorre

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22

Bueno, Natalia Fernanda. "Caracterização de dois pares efetor/inibidor associados ao sistema de secreção tipo IV de Xanthomonas citri." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-24082018-094918/.

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O sistema de secreção tipo IV (T4SS) da família de bactérias Xanthomonadaceae transfere efetores (X-Tfes) com a capacidade de matar outras bactérias, conferindo uma vantagem em comunidades bacterianas mistas para colonizar diferentes nichos como o solo ou as superfícies das plantas. Os X-Tfes possuem diferentes domínios putativos com atividades hidrolíticas contra componentes do envelope celular bacteriano do tipo: glicohidrolases, transglicosilases, amidases e lipases. Os X-Tfes por sua atividade biológica inata podem ocasionar dano intracelular para a bactéria que os produz. Para se proteger

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23

Lopes, Thais Pereira. "Caracterização estrutural do complexo de proteinas hipoteticas - XACb0032/XACb0033 da bacteria Xanthomonas axonopodis pv. citri." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248422.

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Orientador: Ljubica Tasic<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-09T16:14:23Z (GMT). No. of bitstreams: 1 Lopes_ThaisPereira_M.pdf: 827343 bytes, checksum: a4f6f9404835341a96ecd4f5ca467c69 (MD5) Previous issue date: 2007<br>Resumo: A bactéria gram-negativa Xanthomonas axonopodis pv. citri (Xac) é responsável pelo cancro cítrico, uma doença de grande importância econômica em todo o mundo. Seus mecanismos de virulência ainda são pouco conhecidos, mas acredita-se que o processo de translocação das proteínas de v

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24

Souza, Diorge Paulo de. "Estudos estruturais e de interações proteína-proteína envolvendo componentes de um sistema de secreção do tipo IV de Xanthomonas axonopodis pv. citri." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-08112010-092717/.

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Xanthomonas axonopodis pv. citri (Xac) é o causador do cancro de plantas cítricas. Entre os potenciais fatores de virulência codificados por Xac, está o Sistema de Secreção do Tipo IV (T4SS), um grande complexo multiprotéico que atravessa o periplasma e as membranas interna e externa de bactérias Gram-negativas. O T4SS está envolvido com secreção de proteínas e/ou DNA para o meio extracelular ou diretamente no interior da célula do hospedeiro. Este Sistema requer tipicamente 12 proteínas para realizar suas funções: VirB1-VirB11 e VirD4. O T4SS codificado pelo cromossomo de Xac está aparentemen

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25

Arantxa, Camus Etchecopar. "Mécanismes moléculaires impliqués dans la formation de biofilm à l’interface eau-composés organiques hydrophobes." Thesis, Pau, 2014. http://www.theses.fr/2014PAUU3032/document.

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Les composés organiques hydrophobes (HOC), une grande famille de molécules naturelles ou d’origine anthropique incluant les lipides et les hydrocarbures, constituent une part significative de la matière organique dans les écosystèmes marins. Du fait de leur faible solubilité dans l’eau, les bactéries qui les dégradent requièrent la mise en place de fonctions cellulaires spécifiques permettant d’augmenter la fraction assimilable de ces HOC. La formation de biofilms à l’interface eau-HOC est une de ces stratégies adaptatives. C’est le cas pour Marinobacter hydrocarbonoclasticus SP17, modèle d’ét

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26

Santos, Netto Diogo dos. "Desenvolvimento de um banco de dados para classificação e análise de sistemas de secreção do tipo IV bacteriano." Laboratório Nacional de Computação Científica, 2008. https://tede.lncc.br/handle/tede/120.

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Made available in DSpace on 2015-03-04T18:51:16Z (GMT). No. of bitstreams: 1 Anexos-Final.pdf: 7146890 bytes, checksum: bb4f151b856a0b67e03a2261753fccfe (MD5) Previous issue date: 2008-10-31<br>Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior<br>The type IV secretion system can be classified as a large family of macromolecule transporters divided in three recognized sub-families involved in different bacterial functions. The major sub-family of T4SS is the conjugation system, which allows transfer of genetic material as a nucleoprotein via cell contact among bacteria. Analogousl

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27

Dangla, Pélissier Gauthier. "Identification et caractérisation des régulateurs du transfert horizontal de l’îlot de pathogénicité PAPI-1 chez Pseudomonas aeruginosa PA14." Thesis, Aix-Marseille, 2020. http://www.theses.fr/2020AIXM0136.

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Le transfert horizontal d’ADN est un des moteurs importants de l’évolution. Par ce biais, les bactéries acquièrent de nouvelles voies métaboliques, résistent à de plus en plus de stress environnementaux et s’adaptent aux stratégies thérapeutiques. Chez P. aeruginosa PA14, l’îlot de pathogénicité majeur acquis par transfert horizontal est nommé PAPI-1. Cet îlot augmente considérablement la virulence de P. aeruginosa PA14. Cet îlot, appartenant à la famille des ICE, est capable de se transmettre de façon autonome au sein de l’espèce P. aeruginosa via une machinerie de conjugaison (SST4-GI) impli

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28

Jiménez, Soto Luisa Fernanda [Verfasser]. "Studies on the function of the Cag Type IV Secretion System of Helicobacter pylori with integrin β1 [Beta-1] / submitted by Luisa Fernanda Jiménez Soto". 2009. http://d-nb.info/997741716/34.

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29

Morgan, John Kent 1974. "Analysis of the Coxiella burnetii type iv secretion system region I during infection." 2009. http://digital.library.okstate.edu/etd/Morgan_okstate_0664D_10554.pdf.

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30

Kohler, Petra L. "Components of the Neisseria gonorrhoeae type IV secretion system and their interactions with peptidoglycan." 2008. http://www.library.wisc.edu/databases/connect/dissertations.html.

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31

Sharifahmadian, Mahzad. "Structural and Biochemical Characterization of VirB8 Protein in Type IV Secretion Systems." Thèse, 2017. http://hdl.handle.net/1866/19323.

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Secretion is the passage of macromolecules across cellular membranes. In bacteria, secretion is essential for virulence and survival. Gram-negative bacteria use specialized envelope-spanning multiprotein complexes to secrete macromolecules called type IV secretion system (T4SS). T4SSs mediate the secretion of monomeric proteins, multisubunit protein toxins and nucleoprotein complexes. Also, they contribute to the horizontal spread of plasmid-encoded antibiotic resistance genes. Consequently, they are potential targets for antivirulence drugs. Gram- negative bacteria have two membranes that the

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32

Pabón, Wilmara Salgado. "Neisseria gonorrhoeae processing of chromosomal DNA for direct secretion via a type IV secretion system : requirement of a novel relaxase homologue /." 2008. http://www.library.wisc.edu/databases/connect/dissertations.html.

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33

Um, Nlend Ingrid. "New insights into small molecules inhibitors and protein-protein interactions of VirB8 : a critical conserved component of the type IV secretion system." Thèse, 2015. http://hdl.handle.net/1866/13799.

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34

Mary, Charline. "Analyse du rôle de l’interaction de VirB6 avec VirB10 dans le système de sécrétion de type IV." Thèse, 2018. http://hdl.handle.net/1866/21188.

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35

Casu, Bastien. "Caractérisation biochimique, structurale et inhibition du système de sécrétion de type IV par l’étude des protéines VirB8." Thèse, 2018. http://hdl.handle.net/1866/20745.

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