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Relevant bibliographies by topics / Calceolarioside E

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Academic literature on the topic 'Calceolarioside E'

Author: Grafiati

Published: 4 June 2025

Last updated: 8 July 2025

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Journal articles on the topic "Calceolarioside E"

1

Pieretti, Stefano, Anella Saviano, Adriano Mollica, Azzurra Stefanucci, Anna Maria Aloisi, and Marcello Nicoletti. "Calceolarioside A, a Phenylpropanoid Glycoside from Calceolaria spp., Displays Antinociceptive and Anti-Inflammatory Properties." Molecules 27, no. 7 (2022): 2183. http://dx.doi.org/10.3390/molecules27072183.

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Phenylpropanoid glycosides are a class of natural substances of plant origin with interesting biological activities and pharmacological properties. This study reports the antinociceptive and anti-inflammatory effects of calceolarioside A, a phenylpropanoid glycoside previously isolated from various Calceolaria species. In models of acute nociception induced by thermal stimuli, such as the hot plate and tail flick test, calceolarioside administered at doses of 1, 5, and 10 μg in the left cerebral ventricles did not modify the behavioral response of mice. In an inflammatory based persistent pain model as the formalin test, calceolarioside A at the high dose tested (100 μg/paw) reduced the licking activity induced by formalin by 35% in the first phase and by 75% in the second phase of the test. In carrageenan-induced thermal hyperalgesia, calceolarioside A (50 and 100 μg/paw) was able to significantly reverse thermal hyperalgesia induced by carrageenan. The anti-inflammatory activity of calceolarioside A was then assessed using the zymosan-induced paw edema model. Calceolarioside A (50 and 100 μg/paw) induced a significant reduction in the edema from 1 to 4 h after zymosan administration. Measuring IL-6, TNFα, and IL-1β pro-inflammatory cytokines released from LPS-stimulated THP-1 cells, calceolarioside A in a concentration-dependent manner reduced the release of these cytokines from THP-1 cells. Taken together, our results highlight, for the first time, the potential and selective anti-inflammatory properties of this natural-derived compound, prompting its rationale use for further investigations.

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2

Amirova, Kristiana M., Petya A. Dimitrova, Andrey S. Marchev, et al. "Biotechnologically-Produced Myconoside and Calceolarioside E Induce Nrf2 Expression in Neutrophils." International Journal of Molecular Sciences 22, no. 4 (2021): 1759. http://dx.doi.org/10.3390/ijms22041759.

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The pathological manifestation of various diseases can be suppressed by the activation of nuclear factor erythroid 2 p45-related factor 2 (Nrf2), a transcriptional regulator of the cellular redox balance. Haberlea rhodopensis Friv. is a resurrection plant species endemic for Bulgaria, containing biologically active phenylethanoid glycosides that might possess antioxidant or redox activity. This study aimed to analyze the metabolic profile of in vitro cultured H. rhodopensis and to identify molecules that increase Nrf2 expression in bone marrow neutrophils. Fractions B, D, and E containing myconoside, or myconoside and calceolarioside E in ratios 1:0.6 and 0.25:1 were found to be the most active ones. Fraction B (200 µg/mL) improved neutrophil survival and strongly increased the Nrf2 intracellular level, while D and E, as well as, myconoside and calceolarioside E at the same ratios had a superior effect. Calceolarioside E (32 µg/mL) had stronger activity than myconoside, the effect of which was very similar to that of 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester (CDDO-Me), used as a positive control. These data indicate that both molecules, used alone or in combination have stimulatory activity on the endogenous Nrf2 level, indicating their therapeutic potential to regulate the cellular redox homeostasis oxidative stress-associated pathologies.

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3

Amirova, Kristiana, Petya Dimitrova, Andrey Marchev, et al. "Biotechnologically-Produced Myconoside and Calceolarioside E Induce Nrf2 Expression in Neutrophils." International Journal of Molecular Sciences 22, no. 4 (2021): 1759. https://doi.org/10.3390/ijms22041759.

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The pathological manifestation of various diseases can be suppressed by the activation of nuclear factor erythroid 2 p45-related factor 2 (Nrf2), a transcriptional regulator of the cellular redox balance. Haberlea rhodopensis Friv. is a resurrection plant species endemic for Bulgaria, containing biologically active phenylethanoid glycosides that might possess antioxidant or redox activity. This study aimed to analyze the metabolic profile of in vitro cultured H. rhodopensis and to identify molecules that increase Nrf2 expression in bone marrow neutrophils. Fractions B, D, and E containing myconoside, or myconoside and calceolarioside E in ratios 1:0.6 and 0.25:1 were found to be the most active ones. Fraction B (200 µg/mL) improved neutrophil survival and strongly increased the Nrf2 intracellular level, while D and E, as well as, myconoside and calceolarioside E at the same ratios had a superior effect. Calceolarioside E (32 µg/mL) had stronger activity than myconoside, the effect of which was very similar to that of 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester (CDDO-Me), used as a positive control. These data indicate that both molecules, used alone or in combination have stimulatory activity on the endogenous Nrf2 level, indicating their therapeutic potential to regulate the cellular redox homeostasis oxidative stress-associated pathologies.

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4

Kim, Do-Sung, Hyung-Ryong Kim, Eun-Rhan Woo, et al. "Protective effect of calceolarioside on adriamycin-induced cardiomyocyte toxicity." European Journal of Pharmacology 541, no. 1-2 (2006): 24–32. http://dx.doi.org/10.1016/j.ejphar.2006.04.045.

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5

Judeh, Zaher, and Duc Khong. "Short Synthesis of Phenylpropanoid Glycosides Calceolarioside A and Syringalide B." Synlett 29, no. 08 (2018): 1079–83. http://dx.doi.org/10.1055/s-0036-1591753.

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An efficient and practical three-step synthesis of phenylpropanoid glycosides calceolarioside A and syringalide B in >62% overall yield is disclosed. The key step involves the chemoselective and regioselective direct O-4 cinnamoylation of unprotected 2-phenylethyl-β-d-glucosides with cinnamic anhydrides using a chiral 4-pyrrolidinopyridine organocatalyst. This approach serves as a model for the short synthesis of phenylpropanoid glycosides acylated at O-4 without protection/deprotection steps.

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6

Khong, Duc Thinh, and Zaher M. A. Judeh. "Short synthesis of phenylpropanoid glycosides calceolarioside-B and eutigoside-A." Tetrahedron Letters 58, no. 1 (2017): 109–11. http://dx.doi.org/10.1016/j.tetlet.2016.11.116.

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7

Poddar, Avijit, Anindita Banerjee, Srijani Ghanta, and Sharmila Chattopadhyay. "In vivo Efficacy of Calceolarioside A against Experimental Visceral Leishmaniasis." Planta Medica 74, no. 5 (2008): 503–8. http://dx.doi.org/10.1055/s-2008-1034373.

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8

Zhou, Yang, Junxin Zhou, Jianyong Chen, et al. "Effects of Zinc, Manganese, and Molybdenum Fertilizers on Growth and Main Medicinal Metabolites of Stauntonia leucantha Leaves." Horticulturae 11, no. 2 (2025): 123. https://doi.org/10.3390/horticulturae11020123.

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Zinc, manganese, and molybdenum have a significant impact on plant growth and the accumulation of metabolites. However, the impact of zinc, manganese, and molybdenum on the growth and metabolic substances of Stauntonia leucantha leaves is still unclear. To explore the effects of zinc, manganese, and molybdenum on growth and main medicinal metabolites of Stauntonia leucantha leaves, to provide a reference for the fertilizer application method of Stauntonia leucantha, a three-factor, three-level orthogonal design with five-year-old field Stauntonia leucantha as the test material. The results showed that fertilization with zinc and molybdenum significantly enhanced the medicinal value of Stauntonia leucantha leaves. The leaf growth of Stauntonia leucantha mainly concentrated in 0–120 days after fertilizer application and gradually slowed down in 120–180 days after fertilizer application, significantly affected by zinc and manganese. Zinc significantly increased the content of chlorophyll, oleanolic acid, rutin, and calceolarioside B. Manganese significantly increased the content of chlorophyll and rutin while inhibiting the accumulation of oleanolic acid and calceolarioside B. Molybdenum significantly increased the content of oleanolic acid and rutin but did not affect chlorophyll b content. Based on a comprehensive analysis, the optimum fertilizer combination for leaf quality of Stauntonia leucantha leaves was identified as Zn3Mn1Mo3 (T7), 6 g/plant of zinc sulfate, 3 g/plant of ammonium molybdate, but no manganese sulfate.

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9

Ali, Iqra, Muhammad Asif Rasheed, Simona Cavalu, et al. "Identification of Natural Lead Compounds against Hemagglutinin-Esterase Surface Glycoprotein in Human Coronaviruses Investigated via MD Simulation, Principal Component Analysis, Cross-Correlation, H-Bond Plot and MMGBSA." Biomedicines 11, no. 3 (2023): 793. http://dx.doi.org/10.3390/biomedicines11030793.

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The pandemic outbreak of human coronavirus is a global health concern that affects people of all ages and genders, but there is currently still no effective, approved and potential drug against human coronavirus, as many other coronavirus vaccines have serious side effects while the development of small antiviral inhibitors has gained tremendous attention. For this research, HE was used as a therapeutic target, as the spike protein displays a high binding affinity for both host ACE2 and viral HE glycoprotein. Molecular docking, pharmacophore modelling and virtual screening of 38,000 natural compounds were employed to find out the best natural inhibitor against human coronaviruses with more efficiency and fewer side effects and further evaluated via MD simulation, PCA, DCCR and MMGBSA. The lead compound ‘Calceolarioside B’ was identified on the basis of pharmacophoric features which depict favorable binding (ΔGbind −37.6799 kcal/mol) with the HE(5N11) receptor that describes positive correlation movements in active site residues with better stability, a robust H-bond network, compactness and reliable ADMET properties. The Fraxinus sieboldiana Blume plant containing the Calceolarioside B compound could be used as a potential inhibitor that shows a higher efficacy and potency with fewer side effects. This research work will aid investigators in the testing and identification of chemicals that are effective and useful against human coronavirus.

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10

Hennebelle, Thierry, Sevser Sahpaz, Henry Joseph, and François Bailleul. "Phenolics and Iridoids of Lippia Alba." Natural Product Communications 1, no. 9 (2006): 1934578X0600100. http://dx.doi.org/10.1177/1934578x0600100906.

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The phytochemical investigation of polar extracts of Lippia alba led to the isolation of a new acetylated flavonoid, apigenin-7-O-[(3-O-acetyl)β-D-glucopyranuronyl(1→2)]-β-D-glucopyranuronide, and of seventeen known compounds: seven iridoids (theveside, geniposidic acid, shanzhiside methyl ester, caryoptoside, 8-epi-loganin, mussaenoside and geniposide), six phenylpropanoids (cistanoside F, forsythoside B, calceolarioside E, acteoside, isoacteoside and 2-acetylacteoside) and four flavonoids (apigenin-7-O-glucuronide, luteolin-7-O-glucuronide, apigenin-7-O-diglucuronide and luteolin-7-O-diglucuronide).

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