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Journal articles on the topic 'Calcified lesions'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Golub, Ilana S., Angela Misic, Lucia P. Schroeder, et al. "Calcific coronary lesions: management, challenges, and a comprehensive review." AIMS Medical Science 11, no. 3 (2024): 292–317. http://dx.doi.org/10.3934/medsci.2024021.

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<p>As the prevalence of coronary artery disease continues to increase worldwide, understanding the nuances of complex calcific coronary lesions becomes paramount. Coronary artery calcium (CAC) is a well-established, widely available, and highly specific marker of subclinical and advanced atherosclerosis. It remains a vital adjudicator of atherosclerotic cardiovascular disease (ASCVD) and facilitates the up- or down-stratifying of asymptomatic, intermediate risk patients. Notably, the high prevalence of CAC in coronary heart disease (CHD) patients makes the percutaneous treatment of heavi

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2

Satish, K., M. Sandeep, and G. Indrani. "Comparison of Outcomes After Percutaneous Coronary Intervention Between Calcified and Nonclacified Lesions." Indian Journal of Cardiovascular Disease in Women WINCARS 02, no. 02 (2017): 027–31. http://dx.doi.org/10.1055/s-0038-1656406.

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AbstractIntroduction: Coronary artery calcification increases with age and associated with significant major adverse cardiovascular events. The presence of calcification makes the percutaneous coronary interventions difficult and associated with peri-procedural complications. The main objective of our study is to evaluate the outcome of patients with calcific coronary lesions compared with non-calcific lesions.Methods: Patients admitted in the cardiology department with either chronic stable angina or acute coronary syndrome who underwent percutaneous coronary interventions were included and d

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Annam, Sharath Reddy, Anil Krishna Gundala, Nitin Naik, and Lokanath Seepana. "Sequential rotablation for calcified tandem right coronary artery lesions with guide extension assistance." Medicover Journal of Medicine 1, no. 4 (2024): 158–61. https://doi.org/10.4103/mjm.mjm_32_24.

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Calcific coronary artery disease presents a major challenge for percutaneous coronary intervention as it can be associated with stent delivery failure and suboptimal stent expansion. Currently, numerous therapeutic options are available for modifying calcific coronary plaques, and also coronary imaging to assess adequacy of plaque modification. Mechanical debulking with rotational atherectomy is the time trusted plaque modification strategies for heavily calcified and recalcitrant coronary lesions prior to stenting. We report a rare case with calcified tandem right coronary artery lesions in w

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Lugenbiel, Ira, Michaela Grebner, Qianxing Zhou, et al. "Treatment of femoropopliteal lesions with the AngioSculpt scoring balloon – results from the Heidelberg PANTHER registry." Vasa 47, no. 1 (2018): 49–55. http://dx.doi.org/10.1024/0301-1526/a000671.

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Abstract. Background: Treatment of calcified femoropopliteal lesions remains challenging, even in the era of drug-eluting balloon angioplasty. Lesion recoil and dissections after standard balloon angioplasty in calcific lesions often require subsequent stent implantation. Additionally, poor patency rates in calcified lesions despite the use of drug-eluting balloons may be due to the limited penetration depth of the antiproliferative drug in the presence of vascular calcium deposits. Therefore, preparation of calcified lesions with the AngioSculpt™ scoring balloon might be a valuable option eit

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Zelaya, R., and C. J. Atkinson. "Pictorial Review of Calcified Pseudoneoplasm of the Neuroaxis and Other Calcified Intracranial Lesions." Neurographics 12, no. 1 (2022): 1–16. http://dx.doi.org/10.3174/ng.2100006.

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Neuroimaging is an essential tool in characterizing calcified intracranial lesions. This article outlines a pictorial review of different calcified lesions of the neuroaxis with discussion of distinguishing radiologic features and clinical and histologic characteristics. There will be an emphasis on the uncommon histologic entity known as calcified pseudoneoplasm of the neuroaxis (CAPNON), a non-neoplastic lesion that is sometimes mistaken for the more common neoplastic and non-neoplastic lesions. It is essential for radiologists to identify key distinguishing imaging features of various calci

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6

Consul, Nikita, Aradhana M. Venkatesan, Katherine J. Blair, et al. "Calcified Adrenal Lesions." Journal of Computer Assisted Tomography 44, no. 2 (2020): 178–87. http://dx.doi.org/10.1097/rct.0000000000000980.

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7

Cialdella, Pio, Sonia Cristina Sergi, Giuseppe Zimbardo, et al. "Calcified coronary lesions." European Heart Journal Supplements 25, Supplement_C (2023): C68—C73. http://dx.doi.org/10.1093/eurheartjsupp/suad009.

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Abstract The treatment of calcific coronary lesions is still a major interventional issue in haemodynamics laboratories. The prevalence of the disease is even increasing, considering the general ageing of the population undergoing coronarography, as well as the often associated comorbidities. In recent years, new devices have been developed that allow both better identification and also better treatment of these lesions. The aim of this review is to summarize both imaging modalities and dedicated techniques and materials, thus providing a kind of compendium for the treatment approach.

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8

Caesario, Fahreza, and Mohammad Saifur Rohman. "How to decide appropriate percutaneous coronary intervention (PCI) technique for managing heavy calcified coronary lesions: serial case-report." Heart Science Journal 5, no. 4 (2024): 87–91. http://dx.doi.org/10.21776/ub.hsj.2024.005.04.15.

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Background: Coronary artery calcification (CAC) is still challenging for interventional cardiologists. Their contribution to major adverse cardiac events occurs from the high risk of stent thrombosis or in-stent restenosis and target lesion revascularization. Optimal preparation, such as coronary plaque modification before stenting, is required to reduce the risk of periprocedural adverse events. This case presentation aimed to describe the appropriate management of heavy calcified coronary lesions. Case Presentation: Two cases of heavy calcified coronary lesions with different baselines as Ac

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Tumminello, Gabriele, Chiara Cavallino, Andrea Demarchi, and Francesco Rametta. "Bail-out unexpanded stent implantation in acute left main dissection treated with intra coronary lithotripsy: a case report." European Heart Journal - Case Reports 3, no. 4 (2019): 1–5. http://dx.doi.org/10.1093/ehjcr/ytz172.

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Abstract Background The percutaneous treatment of heavily calcified coronary lesions is challenging and presents high rate of complications. Unexpandable stent is one of the most serious complication. Both of these conditions may benefit from the intracoronary lithotripsy (ICL-Shockwave®), a new coronary percutaneous technique. Case summary This case report describes a man treated with percutaneous coronary intervention (PCI) for a left main (LM) severe calcified lesion. The PCI was complicated by a huge dissection of LM in a not completely expandable lesion. A bail-out stent implantation was

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10

Dash, Debabrata. "Managing Calcified Coronaries: the Bugaboo of Percutaneous Coronary Intervention." Clinical Cardiology and Cardiovascular Interventions 04, no. 06 (2021): 01–12. http://dx.doi.org/10.31579/2641-0419/139.

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Background Percutaneous coronary intervention (PCI) of lesions with heavily coronary artery calcium (CAC) still represents a challenge for interventionists, with increased risk of immediate complications, late failure due to stent underexpansion and malapposition, and consequently poor clinical outcome. In this focused review, we provide the summary of principles, technique and contemporary evidence for various existing and emergent plaque modifying strategies. Main text PCI of lesions with heavy CAC still poses a challenge for the interventionists due to an increased risk of incomplete lesion

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Allali, Abdelhakim, Mohamed Abdel-Wahab, Hussein Traboulsi, et al. "Impact of Lesion Preparation Technique on Side Branch Compromise in Calcified Coronary Bifurcations: A Subgroup Analysis of the PREPARE-CALC Trial." Journal of Interventional Cardiology 2020 (November 11, 2020): 1–8. http://dx.doi.org/10.1155/2020/9740938.

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Objectives. To analyze the impact of different techniques of lesion preparation of severely calcified coronary bifurcation lesions. Background. The impact of different techniques of lesion preparation of severely calcified coronary bifurcation lesions is poorly investigated. Methods. We performed an as-treated analysis on 47 calcified bifurcation lesions treated with scoring/cutting balloons (SCB) and 68 lesions treated with rotational atherectomy (RA) in the PREPARE-CALC trial. Compromised side branch (SB) as assessed in the final angiogram was the primary outcome measure and was defined as a

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Grujić, Milan, Stefan Živković, and Aleksandar Davidović. "Rotary atherectomy: Method of preparation of heavily calcified coronary artery lesions." Timocki medicinski glasnik 47, no. 4 (2022): 148–52. http://dx.doi.org/10.5937/tmg2204148g.

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Calcified lesions of coronary arteries still represent a major challenge in interventional cardiology. The sign is advanced atherosclerosis, associated with multivessel disease and the presence of complex lesions, including long lesions, chronic total occlusions, and bifurcations. Today, there are several strategies for modifying calcified lesions before percutaneous coronary intervention. They can be divided into strategies without atherectomy and strategies with atherectomy. Non-atherectomy strategies include modification balloons and intravascular lithotripsy. Atherectomy strategies are aim

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13

Kaufman, Alan J., and Stefan Tigges. "Mammography of calcified Lesions." Contemporary Diagnostic Radiology 14, no. 4 (1991): 1. http://dx.doi.org/10.1097/00219246-199114040-00001.

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14

Ueki, Yasushi, Tatsuhiko Otsuka, Kiyoshi Hibi, and Lorenz Räber. "The Value of Intracoronary Imaging and Coronary Physiology When Treating Calcified Lesions." Interventional Cardiology Review 14, no. 3 (2019): 164–68. http://dx.doi.org/10.15420/icr.2019.16.r1.

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Heavily calcified coronary artery lesions hinder the delivery of devices and limit stent expansion, resulting in low procedural success and poor clinical outcomes driven by an increase in restenosis and stent thrombosis. Intracoronary imaging provides a more precise assessment of lesions and is a critical step when deciding whether the lesion needs to be prepared with atherectomy devices. Physiological assessment of lesion significance is an important consideration to avoid unnecessary stenting. This article summarises the current data on the value of intracoronary imaging and functional asses

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15

Dini, Carlotta Sorini, Giulia Nardi, Francesca Ristalli, Alessio Mattesini, Brunilda Hamiti, and Carlo Di Mario. "Contemporary Approach to Heavily Calcified Coronary Lesions." Interventional Cardiology Review 14, no. 3 (2019): 154–63. http://dx.doi.org/10.15420/icr.2019.19.r1.

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Percutaneous treatment of heavily calcified coronary lesions still represents a challenge for interventional cardiology, with higher risk of immediate complications, late failure due to stent underexpansion and malapposition, and consequently poor clinical outcome. Good characterisation of calcium distribution with multimodal imaging is important to improve the successful treatment of these lesions. The use of traditional or new dedicated devices for the treatment of calcified lesions allows better lesion preparation; therefore, it is important that we know the different mechanisms and technic

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16

Van, Hoang. "Study on the characteristics of coronary calcification by Intravascular Ultrasound (IVUS)." Tạp chí Phẫu thuật Tim mạch và Lồng ngực Việt Nam 35 (January 6, 2022): 188–95. http://dx.doi.org/10.47972/vjcts.v35i.699.

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Background: Percutaneous coronary angiography is considered the "gold standard" for the diagnosis of coronary artery disease and provides the necessary anatomical information to provide appropriate treatment. The limitation of coronary angiography is the accurate assessment of calcified coronary lesions. Intravascular ultrasonography has many advantages in the assessment of calcified coronary lesions. Methods: The descriptive clinical study. Evaluation of calcified coronary artery lesions by intravascular ultrasound Results: From January 2019 to December 2019, at the Hanoi Heart In

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Verma, Archana, Alok Kumar, and Divyata Sachan. "Clinical Characteristics and Risk Factors for Seizures to Recur in Calcified Neurocysticercosis: Prospective Cohort Study." Acta Neurologica Taiwanica 33, no. 4 (2024): 141–46. https://doi.org/10.4103/ant.33-4_112_0052.

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Abstract Aim: Calcification of degenerating neurocysticercosis (NCC) is common and likely to occur late in the degenerative process and is important for seizure foci. The present study was aimed at identifying the clinical and radiological variables associated with seizure recurrence in people with single or multiple calcified NCC lesions. Material and Methods: We evaluated 85 adult patients with calcified NCC lesions for recurrence of seizures during the follow-up period of one year. Results: The mean age of the study population was 24.49 ± 9.17 years. Nocturnal seizures were present in 43.5%

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18

Watanabe, Yusuke, Kenichi Sakakura, Yousuke Taniguchi, et al. "Comparison of clinical outcomes of intravascular ultrasound-calcified nodule between percutaneous coronary intervention with versus without rotational atherectomy in a propensity-score matched analysis." PLOS ONE 15, no. 11 (2020): e0241836. http://dx.doi.org/10.1371/journal.pone.0241836.

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Objectives This study aimed to compare the mid-term clinical outcomes of intravascular ultrasound (IVUS)-calcified nodules between percutaneous coronary intervention (PCI) with and without rotational atherectomy (RA). Background There has been a debate whether to use RA for the revascularization of calcified nodule. Although RA can ablate the calcified structure within calcified nodule and may facilitate adequate stent expansion, RA may provoke severe coronary perforation, because calcified nodule typically shows eccentric calcification. Methods We included 204 lesions with IVUS-calcified nodu

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Naqvi, Syed Mohammad, Syed Yaseen Naqvi, Muhammad Anis Haider, et al. "Kokeshi phenomenon and coronary perforation with rotational atherectomy while treating heavily calcified coronary artery disease: A case report." Medicine 104, no. 17 (2025): e42006. https://doi.org/10.1097/md.0000000000042006.

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Rationale: Coronary artery disease remains a leading cause of morbidity, requiring complex revascularization strategies, especially in patients with heavily calcified lesions. Percutaneous coronary intervention (PCI) is a common treatment, but it carries risks such as coronary artery perforation and the rare Kokeshi phenomenon during rotational atherectomy (RA). This study aims to emphasize the challenges faced in treating heavily calcified coronary lesions, specifically focusing on the rare Kokeshi phenomenon and coronary artery perforation during RA. Patient concerns: We report the case of a

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20

Torp Kristensen, Andreas, Janus C. Jakobsen, and Niels Thue Olsen. "Percutaneous coronary intervention in calcified stenoses: a protocol for a systematic review with meta-analysis, trial sequential analysis and network meta-analysis." BMJ Open 12, no. 9 (2022): e063884. http://dx.doi.org/10.1136/bmjopen-2022-063884.

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IntroductionSeverely calcified coronary stenoses are difficult to treat with percutaneous coronary interventions. The presence of severe calcifications complicates lesion preparation, advancement of stents and achievement of full stent expansion. Intervention in these lesions is associated with an increased risk of complications and procedural failure compared with treatment of less calcified lesions. Due to the high burden of comorbidity, patients with severely calcified lesions are often excluded from interventional trials, and there is little evidence on how to treat these patients.Methods

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21

Rohman, Mohammad S., Jonny K. Fajar, Melly C. Widyaningsih, et al. "Outcomes of first-generation versus second-generation drug-eluting stents in calcified coronary lesions: A meta-analysis." Narra J 5, no. 2 (2025): e2100. https://doi.org/10.52225/narra.v5i2.2100.

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The choice between first-generation drug-eluting stents (DES) and second-generation DES in managing calcified coronary lesions remains a topic of debate. The aim of this study was to compare outcomes between first-generation DES and second-generation DES in patients with calcified coronary lesions. This meta-analysis study was conducted from October to November 2024. The databases used were Embase, Scopus, and PubMed. Relevant articles were collated, and data regarding outcomes in patients with calcified coronary lesions treated with first-generation and second-generation DES were included to

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Petousis, Stylianos, Emmanouil Skalidis, Evangelos Zacharis, George Kochiadakis, and Michalis Hamilos. "The Role of Intracoronary Imaging for the Management of Calcified Lesions." Journal of Clinical Medicine 12, no. 14 (2023): 4622. http://dx.doi.org/10.3390/jcm12144622.

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Interventional cardiologists in everyday practice are often confronted with calcified coronary lesions indicated for percutaneous transluminal coronary angioplasty (PTCA). PTCA of calcified lesions is associated with diverse technical challenges resulting in suboptimal coronary stenting and adverse long-term clinical outcomes. Angiography itself offers limited information regarding coronary calcification, and the adjuvant use of intracoronary imaging such as intravascular ultrasound (IVUS) and Optical Coherence Tomography (OCT) can guide the treatment of calcified coronary lesions, optimizing

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Mody, Rohit. "Coronary Artherectomy and Treatment of Calcified Coronaries." Research International Journal of Cardiology and Cardiovascular Medicine 02, no. 01 (2021): 019–30. http://dx.doi.org/10.37179/rijccm.000010.

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Since the introduction of fi rst balloon angioplasty, the fi eld of interventional cardiology has come a long way and witnessed the development of numerous tools and techniques. However, percutaneous coronary intervention (PCI) of heavily calcifi ed coronary artery lesions has always remained as a challenging scenario as appropriate dilation of these lesions is diffi cult which may lead to inadequate stent deployment and ultimately reduce overall procedural success, increase angiographic complications and subsequent adverse cardiovascular events. Recently, plaque modifi cation using dedicated

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Dumitrascu, Silviu, Daniela Bartos, and Claudiu Ungureanu. "Outcomes after Percutaneous Coronary Intervention in Patients with Extremely Calcified Left Main Lesions." Medicina 59, no. 5 (2023): 825. http://dx.doi.org/10.3390/medicina59050825.

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Background and Objectives: Available data with regard to the outcomes of patients with severely calcified left main (LM) lesions after revascularization by percutaneous coronary intervention (PCI) when compared to non-calcified LM lesions is unclear. Materials and Methods: The present study sought to retrospectively investigate in hospital and 1 year post-intervention outcomes of patients with extremely calcified LM lesions after PCI facilitated by calcium-dedicated devices (CdD). Seventy consecutive patients with LM PCI were included. CdD requirement was based on suboptimal results after ball

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Gedela, Maheedhar, Shenjing Li, Udit Bhatnagar, Adam Stys, and Tomasz Stys. "Orbital Atherectomy and Heavily Calcified Saphenous Vein Graft Intervention." Texas Heart Institute Journal 47, no. 1 (2020): 41–43. http://dx.doi.org/10.14503/thij-18-6640.

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Percutaneous coronary intervention in the diseased saphenous vein graft differs significantly from that in the diseased native coronary artery. After being exposed to arterial pressures over time, vein grafts have substantially different plaque characteristics, with more inflammatory cells, more diffuse disease, and less calcification. Severe calcification of saphenous vein grafts, although uncommon, poses a high risk of stent underexpansion. Orbital atherectomy for treatment of de novo calcified coronary lesions has been associated with better outcomes at 5-year follow-up. However, there are

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Caiazzo, Gianluca, Carlo Di Mario, Elvin Kedhi, and Giuseppe De Luca. "Current Management of Highly Calcified Coronary Lesions: An Overview of the Current Status." Journal of Clinical Medicine 12, no. 14 (2023): 4844. http://dx.doi.org/10.3390/jcm12144844.

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The amount of coronary calcium strongly correlates with the degree of atherosclerosis and, therefore, with the rate of future cardiac events. Calcified coronary lesions still represent a challenge for interventional cardiologists, bringing not only a higher risk of immediate complications during percutaneous coronary interventions (PCI), but also a higher risk of late stent failure due to under-expansion and/or malapposition, and therefore, have a relevant prognostic impact. Accurate identification of the calcified plaques together with the analysis of their distribution pattern within the ves

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Gupta, Ankush, Sanya Chhikara, Navreet Singh, and Krishna Prasad. "Optical coherence tomography-guided management of underexpanded stent in calcified coronary lesion." BMJ Case Reports 14, no. 1 (2021): e239143. http://dx.doi.org/10.1136/bcr-2020-239143.

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Calcified lesions often result in undilatable lesions, balloon dog-boning, poor device delivery as well as underexpanded stents (UES). This leads to an increased risk of acute and chronic stent failure. A 49-year-old man was admitted with anterior wall myocardial infarction and angiogram showed a diffuse calcific left anterior descending artery/diagonal lesion, which was stented with two overlapping drug-eluting stents. Angiogram after post-dilatation showed UES. Optical coherence tomography (OCT) confirmed UES with 58% expansion, minimum stent area (MSA) of 2.91 mm2 and 360° calcium arc aroun

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Oliveira, Marcos C. B., Maria G. M. Martin, Miriam H. Tsunemi, Gilson Vieira, and Luiz H. M. Castro. "Small calcified lesions suggestive of neurocysticercosis are associated with mesial temporal sclerosis." Arquivos de Neuro-Psiquiatria 72, no. 7 (2014): 510–16. http://dx.doi.org/10.1590/0004-282x20140080.

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Recent studies have suggested a possible relationship between temporal lobe epilepsy with mesial temporal sclerosis (MTS) and neurocysticercosis (NC). We performed a case-control study to evaluate the association of NC and MTS. Method: We randomly selected patients with different epilepsy types, including: MTS, primary generalized epilepsy (PGE) and focal symptomatic epilepsy (FSE). Patients underwent a structured interview, followed by head computed tomography (CT). A neuroradiologist evaluated the scan for presence of calcified lesions suggestive of NC. CT results were matched with patients’

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Sotomi, Yohei, Richard A. Shlofmitz, Antonio Colombo, Patrick W. Serruys, and Yoshinobu Onuma. "Patient Selection and Procedural Considerations for Coronary Orbital Atherectomy System." Interventional Cardiology Review 11, no. 1 (2016): 33. http://dx.doi.org/10.15420/icr.2015:19:2.

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Despite advances in technology, percutaneous coronary intervention (PCI) of severely calcified coronary lesions remains challenging. Rotational atherectomy is one of the current therapeutic options to manage calcified lesions, but has a limited role in facilitating the dilation or stenting of lesions that cannot be crossed or expanded with other PCI techniques due to unfavourable clinical outcome in long-term follow-up. However the results of orbital atherectomy presented in the ORBIT I and ORBIT II trials were encouraging. In addition to these encouraging data, necessity for sufficient lesion

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Sotomi, Yohei, Richard A. Shlofmitz, Antonio Colombo, Patrick W. Serruys, and Yoshinobu Onuma. "Patient Selection and Procedural Considerations for Coronary Orbital Atherectomy System." Interventional Cardiology Review 11, no. 1 (2016): 33. http://dx.doi.org/10.15420/icr.2016.11.01.33.

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Despite advances in technology, percutaneous coronary intervention (PCI) of severely calcified coronary lesions remains challenging. Rotational atherectomy is one of the current therapeutic options to manage calcified lesions, but has a limited role in facilitating the dilation or stenting of lesions that cannot be crossed or expanded with other PCI techniques due to unfavourable clinical outcome in long-term follow-up. However the results of orbital atherectomy presented in the ORBIT I and ORBIT II trials were encouraging. In addition to these encouraging data, necessity for sufficient lesion

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Rola, Piotr, Szymon Włodarczak, Mateusz Barycki, et al. "Safety and Efficacy of Orbital Atherectomy in the All-Comer Population: Mid-Term Results of the Lower Silesian Orbital Atherectomy Registry (LOAR)." Journal of Clinical Medicine 12, no. 18 (2023): 5842. http://dx.doi.org/10.3390/jcm12185842.

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Background: Coronary calcifications represent a challenging subset for the interventional cardiologist performing percutaneous coronary intervention (PCI) and are well-established risk factors for adverse outcomes. Adequate plaque modification prior to stent implantation is critical to achieve an optimal outcome following PCI. Recently, a novel orbital atherectomy device has been introduced into clinical practice to modify calcified plaques. We evaluated the mid-term safety and efficacy of OA in a high-risk “all-comers” population. Methods: We evaluated 96 consecutive patients with severely ca

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Takase, Yukinori, Tatsuya Tanaka, Satoshi Anai, et al. "Usefulness of non-slip element percutaneous transluminal angioplasty scoring balloons in treating severe calcified lesions of the carotid artery for carotid artery stenting: A case report." Surgical Neurology International 15 (March 15, 2024): 91. http://dx.doi.org/10.25259/sni_923_2023.

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Background: Treatment of calcified lesions with conventional angioplasty balloons can be difficult due to insufficient lumen expansion, high dissection rates, and repeated revascularization. We report a case in which a scoring balloon was used in lesions resistant to angioplasty with a semi-compliant balloon. Case Description: A 72-year-old man presented with severe stenosis and a highly calcified lesion in the right cervical internal carotid artery. Right carotid artery stenting (CAS) was planned to prevent future ischemic stroke events. Conventional semi-compliant balloon angioplasty was uns

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Li, Jiasong, Hongshuai Cao, Meng Li, Lixia Shu, and Changyan Lin. "A study of balloon type on calcified coronary lesion predilation: A finite element analysis." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, March 16, 2023, 095441192311578. http://dx.doi.org/10.1177/09544119231157853.

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Calcified coronary lesions have been one of the more difficult types of lesion for interventional treatment, and angioplasty is required to break the calcification before stent implantation so that the stent can expand smoothly, however, it remains unclear which type of angioplasty is optimal for different calcified lesions. In this study, a finite element approach was used to model normal balloons, cutting balloons, and AngioSculpt balloons. In addition, calcified lesions of different degrees, thicknesses, and lengths were modeled according to Intravascular ultrasound (IVUS) calcification gra

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Hemetsberger, Rayyan, Tommaso Gori, Ralph Toelg, et al. "Optical Coherence Tomography Assessment in Patients Treated With Rotational Atherectomy Versus Modified Balloons." Circulation: Cardiovascular Interventions 14, no. 3 (2021). http://dx.doi.org/10.1161/circinterventions.120.009819.

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Background: Percutaneous intervention of calcified coronary lesions often requires lesion preparation with either balloon dilatation or atherectomy. We sought to evaluate the impact of lesion preparation strategy on stent expansion following preparation of severely calcified coronary lesions with modified (cutting/scoring) balloons (MB) versus rotational atherectomy (RA) and to evaluate the impact of calcium burden as assessed by optical coherence tomography (OCT) on acute stent performance. Methods: In the PREPARE-CALC trial (Comparison of Strategies to Prepare Severely Calcified Coronary Les

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Nagata, Takako, Yoshiyasu Minami, Aritomo Katsura, et al. "Abstract 13084: Clinical Outcomes and Factors for Adverse Events in Patients With Severe Coronary Calcification Assessed by Optical Coherence Tomography." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.13084.

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Introduction: Severe coronary calcification is a known factor for worse clinical and angiographic outcomes after percutaneous coronary intervention (PCI). However, the association between lesion characteristics and post-stent findings and worse clinical outcomes in patients with severely calcified lesions remains to be elucidated. Hypothesis: Among patients with severely calcified lesions, pre and post stent findings assessed by optical coherence tomography (OCT) are associated with future adverse events. Methods: A total of 241 consecutive patients with severely calcified lesions, who underwe

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Sugizaki, Yoichiro, Mitsuaki Matsumura, Yu-Wei Chen, et al. "Stent-Edge Hinge Movement in a Calcified Lesion Is Associated With Increased Prevalence of a Calcified Nodule at Follow-Up." Circulation: Cardiovascular Interventions, May 12, 2025. https://doi.org/10.1161/circinterventions.124.015028.

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BACKGROUND: Coronary stenting alters vessel dynamics, displacing hinge movement closer to stent edges. We aimed to investigate whether calcified nodules (CNs) are more frequent at stent edges associated with calcium. METHODS: In vessels with previously implanted stents evaluated by optical coherence tomography, 4 different calcified lesions were studied: stent-edge calcified lesions with or without a CN, and unstented native calcified lesions with or without a CN. RESULTS: In 801 patients, 989 stent-edge calcified lesions and 354 unstented native calcified lesions were identified. Stent-edge c

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Abe, Hiroshi, Dai Ozaki, Takashi Tokano, and Tohru Minamino. "Successful wire placement into eccentric calcified plaque using intravascular lithotripsy." Egyptian Heart Journal 77, no. 1 (2025). https://doi.org/10.1186/s43044-025-00656-w.

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Abstract Background Eccentric calcified lesions pose significant challenges in percutaneous coronary intervention (PCI), as they are associated with an increased risk of coronary artery perforation and suboptimal stent expansion. Moreover, long-term outcomes with drug-eluting stents (DESs) in these lesions are less favorable. Intravascular lithotripsy (IVL) has emerged as a treatment option for calcified lesions. However, its efficacy in managing eccentric calcified lesions remains uncertain. Case presentation A 70-year-old male presented with angina starting a week ago. He was diagnosed with

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Matsuhiro, Y., M. Nishino, H. Nakamura, et al. "103Maximum calcium thickness is a useful predictor for under expansion after post dilatation in calcified lesions: optical coherence tomographic study." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz747.0031.

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Abstract Background Several reports have revealed that stent under expansion is associated with target lesion failure and calcified lesions usually induced inadequate stent expansion. Contemporary debulking devices such as rotational/orbital atherectomy can modify severe calcified lesions before stenting. However, it is uclear which calcium parameter is most useful predictor for stent expansion in the calcified lesions. Thus, we investigated useful calcium parameters correlating with stent expansion in the calcified lesions. Methods We enrolled 43 consecutive calcified lesions (43 patients) wh

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Sekimoto, Teruo, Yasushi Akutsu, Yuji Hamazaki, et al. "Abstract 13968: Regional Calcified Plaque Score evaluated by Computed Tomographic Angiography for Indicating the Addition of Rotational Atherectomy in Patients With Percutaneous Coronary Intervention." Circulation 132, suppl_3 (2015). http://dx.doi.org/10.1161/circ.132.suppl_3.13968.

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Introduction: Rotational atherectomy (Rota) has been proposed as the best strategy relative to all other percutaneous coronary interventions (PCI) in complex and severely calcified lesions, and the examination of calcified plaque conditions is necessary to determine whether Rota is indicated. Multidetector computed tomography coronary angiography (CTA) can provide non-invasive assessment of calcified plaques with obstructive coronary artery disease. Hypothesis: We hypothesized that regional coronary artery calcium score (CAC) of the target lesion on CTA would aid in deciding whether subsequent

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Misawa, Toru, Tetsumin Lee, Takashi Ashikaga, Toshihiro Nozato, Taishi Yonetsu, and Tetsuo Sasano. "Case Report: Drug-coated balloon after intravascular lithotripsy for the treatment of severely calcified de novo coronary artery lesion." Frontiers in Cardiovascular Medicine 11 (November 18, 2024). http://dx.doi.org/10.3389/fcvm.2024.1470785.

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In patients undergoing percutaneous coronary intervention (PCI), severely calcified lesions remain a great challenge even in the drug-eluting stent (DES) era. Intravascular lithotripsy (IVL) is effective for modification of severely calcified lesions prior to DES implantation. However, the efficacy of PCI with drug-coated balloon (DCB) following IVL has not been fully elucidated. Here, we present a case of severely calcified de novo coronary artery lesion successfully underwent PCI with DCB following IVL under optical coherence tomography (OCT) guidance as well as mid-term follow-up OCT. DCB f

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Chang, Dong-Gune, Jong-Beom Park, Ho-Young Jung, and Kyung Jin Seo. "Cervical myelopathy due to subaxial calcium pyrophosphate dihydrate (CPPD) deposition with simultaneous asymptomatic crowned dens syndrome: two case reports." BMC Musculoskeletal Disorders 21, no. 1 (2020). http://dx.doi.org/10.1186/s12891-020-03736-x.

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Abstract Background There are few reports of cervical myelopathy caused by an attack of subaxial calcium pyrophosphate dihydrate (CPPD) deposition. Moreover, there has been no report on cervical myelopathy by subaxial CPPD deposition with simultaneous asymptomatic crowned dens syndrome (CDS) at the same time. Case presentation The first case was a 68-year-old male complaining of cervical myelopathic symptoms. Plain radiographs, computed tomography (CT) and magnetic resonance imaging (MRI) findings revealed spinal cord compression by calcified round lesions at C4 as well as a calcified lesion b

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Suzuki, Yoriyasu, Masahiro Uehara, Hirohiko Ando, et al. "Clinical outcomes of percutaneous coronary intervention for severely calcified lesions: comparison between the morphologies of severely calcified coronary lesions." Heart and Vessels, September 25, 2024. http://dx.doi.org/10.1007/s00380-024-02466-7.

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AbstractExisting studies evaluating the comparison of clinical outcome of percutaneous coronary intervention (PCI) for severe calcified coronary lesions are limited, and the clinical outcomes of PCI for different morphologies of calcified lesions are controversial. Overall, consecutive 576 lesions with severe calcification that were treated with PCI from 2010 to 2021 at Nagoya Heart Center were investigated. All lesions were assessed using invasive coronary angiogram (CAG) or computed tomography-CAG at 12 months after DES implantation. We divided the patients into three groups based on the res

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Aksoy, A., C. Salazar, U. M. Becher, et al. "P973Intravascular lithotripsy for lesion preparation in calcified coronary lesions: a prospective, observational, two-center registry." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz747.0567.

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Abstract Background Intravascular coronary lithotripsy (IVL) is a novel alternative treatment for heavily calcified lesions. This study sought to determine the strategy success and safety of IVL on calcified lesions in an all-comers cohort of patients. Methods Patients with moderate and severely calcified coronary lesions were screened in two centers in Spain and Germany starting April 2018. Until February 2019, 61 patients with 67 lesions were eligible for IVL. Patients were assigned to the following groups: A) Primary IVL therapy for patients with circumferential calcified de-novo coronary l

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Tokuda, Takahiro, Keisuke Hirano, Akinobu Takemura, and Yasuhiro Oba. "Utility and safety of a novel method using a Wingman catheter for patients with lower extremity arterial disease complicated with severely calcified lesions: Wingman's bevel tip inner catheter removal technique—A prospective cohort study." Health Science Reports 6, no. 9 (2023). http://dx.doi.org/10.1002/hsr2.1586.

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AbstractBackground and AimsIn cases of lower extremity artery disease (LEAD) accompanied by heavily calcified lesions, endovascular treatment becomes necessary at times. To effectively address these challenging calcified lesions, we developed an innovative approach named WINNER (Wingman's bevel tip inner catheter removal) technique. This study investigated the effectiveness and safety of a novel method using the WINNER technique.MethodsThis was a two‐center, prospective observational study. We analyzed the clinical data of patients with LEAD complicated with severely calcified lesions who unde

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Redfors, Björn, Samin K. Sharma, Shigeru Saito, et al. "Novel Micro Crown Orbital Atherectomy for Severe Lesion Calcification." Circulation: Cardiovascular Interventions 13, no. 8 (2020). http://dx.doi.org/10.1161/circinterventions.120.008993.

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Background: Percutaneous coronary intervention of severely calcified lesions carries a high risk of adverse events despite the use of contemporary devices. The Classic Crown Orbital Atherectomy System (OAS) was safe and effective for severely calcified lesion preparation in the ORBIT II study (Evaluate the Safety and Efficacy of OAS in Treating Severely Calcified Coronary Lesions) but was not optimized for tight lesions. COAST (Coronary Orbital Atherectomy System Study) evaluated the safety and efficacy of calcified lesion preparation before stent implantation with the Diamondback 360 Micro Cr

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Chen, Zhaoyang, Mitsuaki Matsumura, Gary S. Mintz, et al. "Prevalence and Impact of Neoatherosclerosis on Clinical Outcomes After Percutaneous Treatment of Second-Generation Drug-Eluting Stent Restenosis." Circulation: Cardiovascular Interventions 15, no. 9 (2022). http://dx.doi.org/10.1161/circinterventions.121.011693.

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Background: Clinical and morphological factors associated with lipidic versus calcified neoatherosclerosis within second-generation drug-eluting stents and the impact of lipidic versus calcified neoatherosclerosis on long-term outcomes after repeat intervention have not been well studied. Methods: A total of 512 patients undergoing optical coherence tomography before percutaneous coronary intervention for second-generation drug-eluting stents in-stent restenosis were included. Neoatherosclerosis was defined as lipidic or calcified neointimal hyperplasia in ≥3 consecutive frames or ruptured lip

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Ohashi, Hiroyuki, Kakuya Kitagawa, Hirohumi Sawada, et al. "Abstract O.69: Coronary Vessel Wall Imaging By Using Multi-detector Computed Tomography And Outcomes In Patients Long After Kawasaki Disease: Potential For Risk Stratification." Circulation 131, suppl_2 (2015). http://dx.doi.org/10.1161/circ.131.suppl_2.o69.

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Background: In acute coronary syndrome (ACS) in adults after Kawasaki disease (KD), acute thrombosis occurs in culprit lesions with calcified intima even in the absence of giant aneurysms (AN) or severe stenosis. Recently, multi-detector computed tomography (MDCT), a non-invasive modality, was shown to have good diagnostic accuracy of detecting IVUS-defined intimal thickening and calcification. We investigated whether MDCT-derived vessel wall lesions are associated with coronary artery lesions (CAL) and outcomes in patients long after KD. Methods: MDCT was performed and analyzed (Vitrea fX, vs

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Wolny, R., A. Zysk, A. Chwala, et al. "Computed tomography for prediction of stent underexpansion after percutaneous recanalization of calcified coronary chronic total occlusions." European Heart Journal 45, Supplement_1 (2024). http://dx.doi.org/10.1093/eurheartj/ehae666.2425.

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Abstract Background Coronary calcifications are the leading cause of stent underexpansion after percutaneous coronary intervention (PCI) and are commonly encountered in chronic total occlusions (CTO). Coronary computed tomography angiography (CCTA) is uniquely suited for pre-procedural assessment of coronary calcifications. Recently quantitative CCTA, providing exact volumes of each plaque component, has shown additional value in future risk assessment compared with conventional qualitative CCTA. Purpose The aim of this study was to evaluate whether CCTA predicts intravascular ultrasound (IVUS

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Sakakura, Kenichi, Hiroyuki Jinnouchi, Yousuke Taniguchi, et al. "Halftime rotational atherectomy: a unique concept for diffuse long severely calcified lesions." Cardiovascular Intervention and Therapeutics, November 10, 2023. http://dx.doi.org/10.1007/s12928-023-00968-1.

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AbstractRotational atherectomy (RA) is technically more difficult in a diffuse calcified lesion than in a focal calcified lesion. We hypothesized that taking a halftime can be another option for RA to the diffuse calcified lesions. Halftime was defined as at least one long break during RA, in which an operator pulled out the Rotablator system from the guide catheter before crossing the lesion. This study aimed to compare the complications between RA with and without halftime. We included 177 diffuse long severely calcified lesions (lesion lengths ≥ 30 mm) that required RA, and divided those le

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Rao, Siddhartha, Anton Hnatov, Trisha Tarra, Amber Amparo, and Mallika Bhargava. "Crossing complex infrapopliteal lesions utilizing a front-end cutting technique: A report of two cases with a novel rotational atherectomy device." SAGE Open Medical Case Reports 11 (January 2023). http://dx.doi.org/10.1177/2050313x231198370.

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Critical limb ischemia represents the most severe stage of peripheral vascular disease and patients often present with complex, calcified infrapopliteal lesions. Atherectomy is an endovascular treatment modality that can be used to debulk otherwise uncrossable lesions. We performed a retrospective, single-center, case report of two patients who presented with critical limb ischemia and whose complex and calcified infrapopliteal lesions were treated with the 1.5 mm Phoenix Atherectomy System after prior failed angioplasty attempts. The 1.5 mm Phoenix Atherectomy System successfully debulked eac

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