Academic literature on the topic 'Calcium activated chlorine channels'

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Journal articles on the topic "Calcium activated chlorine channels"

1

Hartzell, Criss, Ilva Putzier, and Jorge Arreola. "CALCIUM-ACTIVATED CHLORIDE CHANNELS." Annual Review of Physiology 67, no. 1 (2005): 719–58. http://dx.doi.org/10.1146/annurev.physiol.67.032003.154341.

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2

Hao, Feng, Zhong Hai Yuan, Zhi Xin Wang, et al. "Plasmid Construction of TMEM16A-pcDNA3.1 and its Application to Transient and Stable Transfection of FRT Cells." Advanced Materials Research 554-556 (July 2012): 1734–37. http://dx.doi.org/10.4028/www.scientific.net/amr.554-556.1734.

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Calcium-activated chloride channels (CaCCs) play pivotal roles in many physiological Activities, including transepithelial fluid secretion, smooth muscle contraction and sensory transduction. TMEM16A is a bona fide calcium-activated chloride channel,which was discovered by three independent labs in 2008 after Calcium-activated chloride channel current was recorded about thirty years ago. In this study, DNA fragments encoding mouse TMEM16A with green fluorescence protein (GFP) fusion protein were subcloned into pcDNA3.1/Zeo. Transient transfection condition was optimized and Fischer Thyroid epi
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3

Hussy, N. "Calcium-activated chloride channels in cultured embryonic Xenopus spinal neurons." Journal of Neurophysiology 68, no. 6 (1992): 2042–50. http://dx.doi.org/10.1152/jn.1992.68.6.2042.

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1. Single-channel currents were recorded from Xenopus spinal neurons developing in vitro using the patch-clamp technique, to identify the channels underlying the large and small macroscopic Ca(2+)-activated Cl- currents (ICl(Ca)) present in these cells. 2. Channels of large (maxi-channels; 310 pS) and smaller conductance (mini-channels; 50-60 pS) are activated by elevation of cytoplasmic Ca2+ concentration. Channel activity is not altered by subsequent removal of Ca2+ from the bath, arguing against a direct ligand-type Ca2+ dependence. The much higher incidence of channel activation in cell-at
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4

Thomas, Miracle, Mark Simms, and Prosper N’Gouemo. "Activation of Calcium-Activated Chloride Channels Suppresses Inherited Seizure Susceptibility in Genetically Epilepsy-Prone Rats." Biomedicines 10, no. 2 (2022): 449. http://dx.doi.org/10.3390/biomedicines10020449.

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Inherited seizure susceptibility in genetically epilepsy-prone rats (GEPR-3s) is associated with increased voltage-gated calcium channel currents suggesting a massive calcium influx resulting in increased levels of intraneuronal calcium. Cytosolic calcium, in turn, activates many processes, including chloride channels, to restore normal membrane excitability and limit repetitive firing of the neurons. Here we used EACT and T16Ainh-A01, potent activator and inhibitor of calcium-activated channels transmembrane protein 16A (TMEM16A), respectively, to probe the role of these channels in the patho
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5

Yamamura, Hisao. "TMEM16 as calcium-activated chloride channels." Folia Pharmacologica Japonica 142, no. 3 (2013): 144. http://dx.doi.org/10.1254/fpj.142.144.

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6

Li, Weiyan, Christopher Thaler, and Paul Brehm. "Calcium Channels in Xenopus Spinal Neurons Differ in Somas and Presynaptic Terminals." Journal of Neurophysiology 86, no. 1 (2001): 269–79. http://dx.doi.org/10.1152/jn.2001.86.1.269.

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Calcium channels play dual roles in cell signaling by promoting membrane depolarization and allowing entry of calcium ions. Patch-clamp recordings of calcium and calcium-dependent currents from the soma of Xenopus spinal neurons indicate key functional differences from those of presynaptic terminals. Both terminals and somas exhibit prominent high-voltage-activated (HVA) calcium current, but only the soma expresses additional low-voltage-activated (LVA) T-type current. Further differences are reflected in the HVA current; N- and R-type channels are predominant in the soma while the terminal ca
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7

Dibattista, Michele, Asma Amjad, Devendra Kumar Maurya, et al. "Calcium-activated chloride channels in the apical region of mouse vomeronasal sensory neurons." Journal of General Physiology 140, no. 1 (2012): 3–15. http://dx.doi.org/10.1085/jgp.201210780.

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The rodent vomeronasal organ plays a crucial role in several social behaviors. Detection of pheromones or other emitted signaling molecules occurs in the dendritic microvilli of vomeronasal sensory neurons, where the binding of molecules to vomeronasal receptors leads to the influx of sodium and calcium ions mainly through the transient receptor potential canonical 2 (TRPC2) channel. To investigate the physiological role played by the increase in intracellular calcium concentration in the apical region of these neurons, we produced localized, rapid, and reproducible increases in calcium concen
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8

Pozdnyakov, Ilya, Olga Matantseva, and Sergei Skarlato. "Consensus channelome of dinoflagellates revealed by transcriptomic analysis sheds light on their physiology." Algae 36, no. 4 (2021): 315–26. http://dx.doi.org/10.4490/algae.2021.36.12.2.

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Ion channels are membrane protein complexes mediating passive ion flux across the cell membranes. Every organism has a certain set of ion channels that define its physiology. Dinoflagellates are ecologically important microorganisms characterized by effective physiological adaptability, which backs up their massive proliferations that often result in harmful blooms (red tides). In this study, we used a bioinformatics approach to identify homologs of known ion channels that belong to 36 ion channel families. We demonstrated that the versatility of the dinoflagellate physiology is underpinned by
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9

Kaneko, Hiroshi, Frank Möhrlen, and Stephan Frings. "Calmodulin Contributes to Gating Control in Olfactory Calcium-activated Chloride Channels." Journal of General Physiology 127, no. 6 (2006): 737–48. http://dx.doi.org/10.1085/jgp.200609497.

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In sensory neurons of the peripheral nervous system, receptor potentials can be amplified by depolarizing Cl currents. In mammalian olfactory sensory neurons (OSNs), this anion-based signal amplification results from the sequential activation of two distinct types of transduction channels: cAMP-gated Ca channels and Ca-activated Cl channels. The Cl current increases the initial receptor current about 10-fold and leads to the excitation of the neuron. Here we examine the activation mechanism of the Ca-dependent Cl channel. We focus on calmodulin, which is known to mediate Ca effects on various
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10

Lalonde, Melanie, Melanie Kelly, and Steven Barnes. "Calcium-activated chloride channels in the retina." Channels 2, no. 4 (2008): 252–60. http://dx.doi.org/10.4161/chan.2.4.6704.

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