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Journal articles on the topic 'Calcium activated chlorine channels'

Author: Grafiati

Published: 14 March 2023

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1

Hartzell, Criss, Ilva Putzier, and Jorge Arreola. "CALCIUM-ACTIVATED CHLORIDE CHANNELS." Annual Review of Physiology 67, no. 1 (2005): 719–58. http://dx.doi.org/10.1146/annurev.physiol.67.032003.154341.

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2

Hao, Feng, Zhong Hai Yuan, Zhi Xin Wang, et al. "Plasmid Construction of TMEM16A-pcDNA3.1 and its Application to Transient and Stable Transfection of FRT Cells." Advanced Materials Research 554-556 (July 2012): 1734–37. http://dx.doi.org/10.4028/www.scientific.net/amr.554-556.1734.

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Calcium-activated chloride channels (CaCCs) play pivotal roles in many physiological Activities, including transepithelial fluid secretion, smooth muscle contraction and sensory transduction. TMEM16A is a bona fide calcium-activated chloride channel，which was discovered by three independent labs in 2008 after Calcium-activated chloride channel current was recorded about thirty years ago. In this study, DNA fragments encoding mouse TMEM16A with green fluorescence protein (GFP) fusion protein were subcloned into pcDNA3.1/Zeo. Transient transfection condition was optimized and Fischer Thyroid epi

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3

Hussy, N. "Calcium-activated chloride channels in cultured embryonic Xenopus spinal neurons." Journal of Neurophysiology 68, no. 6 (1992): 2042–50. http://dx.doi.org/10.1152/jn.1992.68.6.2042.

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1. Single-channel currents were recorded from Xenopus spinal neurons developing in vitro using the patch-clamp technique, to identify the channels underlying the large and small macroscopic Ca(2+)-activated Cl- currents (ICl(Ca)) present in these cells. 2. Channels of large (maxi-channels; 310 pS) and smaller conductance (mini-channels; 50-60 pS) are activated by elevation of cytoplasmic Ca2+ concentration. Channel activity is not altered by subsequent removal of Ca2+ from the bath, arguing against a direct ligand-type Ca2+ dependence. The much higher incidence of channel activation in cell-at

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4

Thomas, Miracle, Mark Simms, and Prosper N’Gouemo. "Activation of Calcium-Activated Chloride Channels Suppresses Inherited Seizure Susceptibility in Genetically Epilepsy-Prone Rats." Biomedicines 10, no. 2 (2022): 449. http://dx.doi.org/10.3390/biomedicines10020449.

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Inherited seizure susceptibility in genetically epilepsy-prone rats (GEPR-3s) is associated with increased voltage-gated calcium channel currents suggesting a massive calcium influx resulting in increased levels of intraneuronal calcium. Cytosolic calcium, in turn, activates many processes, including chloride channels, to restore normal membrane excitability and limit repetitive firing of the neurons. Here we used EACT and T16Ainh-A01, potent activator and inhibitor of calcium-activated channels transmembrane protein 16A (TMEM16A), respectively, to probe the role of these channels in the patho

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5

Yamamura, Hisao. "TMEM16 as calcium-activated chloride channels." Folia Pharmacologica Japonica 142, no. 3 (2013): 144. http://dx.doi.org/10.1254/fpj.142.144.

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6

Li, Weiyan, Christopher Thaler, and Paul Brehm. "Calcium Channels in Xenopus Spinal Neurons Differ in Somas and Presynaptic Terminals." Journal of Neurophysiology 86, no. 1 (2001): 269–79. http://dx.doi.org/10.1152/jn.2001.86.1.269.

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Calcium channels play dual roles in cell signaling by promoting membrane depolarization and allowing entry of calcium ions. Patch-clamp recordings of calcium and calcium-dependent currents from the soma of Xenopus spinal neurons indicate key functional differences from those of presynaptic terminals. Both terminals and somas exhibit prominent high-voltage-activated (HVA) calcium current, but only the soma expresses additional low-voltage-activated (LVA) T-type current. Further differences are reflected in the HVA current; N- and R-type channels are predominant in the soma while the terminal ca

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7

Dibattista, Michele, Asma Amjad, Devendra Kumar Maurya, et al. "Calcium-activated chloride channels in the apical region of mouse vomeronasal sensory neurons." Journal of General Physiology 140, no. 1 (2012): 3–15. http://dx.doi.org/10.1085/jgp.201210780.

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The rodent vomeronasal organ plays a crucial role in several social behaviors. Detection of pheromones or other emitted signaling molecules occurs in the dendritic microvilli of vomeronasal sensory neurons, where the binding of molecules to vomeronasal receptors leads to the influx of sodium and calcium ions mainly through the transient receptor potential canonical 2 (TRPC2) channel. To investigate the physiological role played by the increase in intracellular calcium concentration in the apical region of these neurons, we produced localized, rapid, and reproducible increases in calcium concen

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8

Pozdnyakov, Ilya, Olga Matantseva, and Sergei Skarlato. "Consensus channelome of dinoflagellates revealed by transcriptomic analysis sheds light on their physiology." Algae 36, no. 4 (2021): 315–26. http://dx.doi.org/10.4490/algae.2021.36.12.2.

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Ion channels are membrane protein complexes mediating passive ion flux across the cell membranes. Every organism has a certain set of ion channels that define its physiology. Dinoflagellates are ecologically important microorganisms characterized by effective physiological adaptability, which backs up their massive proliferations that often result in harmful blooms (red tides). In this study, we used a bioinformatics approach to identify homologs of known ion channels that belong to 36 ion channel families. We demonstrated that the versatility of the dinoflagellate physiology is underpinned by

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9

Kaneko, Hiroshi, Frank Möhrlen, and Stephan Frings. "Calmodulin Contributes to Gating Control in Olfactory Calcium-activated Chloride Channels." Journal of General Physiology 127, no. 6 (2006): 737–48. http://dx.doi.org/10.1085/jgp.200609497.

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In sensory neurons of the peripheral nervous system, receptor potentials can be amplified by depolarizing Cl currents. In mammalian olfactory sensory neurons (OSNs), this anion-based signal amplification results from the sequential activation of two distinct types of transduction channels: cAMP-gated Ca channels and Ca-activated Cl channels. The Cl current increases the initial receptor current about 10-fold and leads to the excitation of the neuron. Here we examine the activation mechanism of the Ca-dependent Cl channel. We focus on calmodulin, which is known to mediate Ca effects on various

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10

Lalonde, Melanie, Melanie Kelly, and Steven Barnes. "Calcium-activated chloride channels in the retina." Channels 2, no. 4 (2008): 252–60. http://dx.doi.org/10.4161/chan.2.4.6704.

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11

Kolesnikov, Dmitrii, Anastasiia Perevoznikova, Konstantin Gusev, Lyubov Glushankova, Elena Kaznacheyeva, and Alexey Shalygin. "Electrophysiological Properties of Endogenous Single Ca2+ Activated Cl− Channels Induced by Local Ca2+ Entry in HEK293." International Journal of Molecular Sciences 22, no. 9 (2021): 4767. http://dx.doi.org/10.3390/ijms22094767.

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Microdomains formed by proteins of endoplasmic reticulum and plasma membrane play a key role in store-operated Ca2+ entry (SOCE). Ca2+ release through inositol 1,4,5-trisphosphate receptor (IP3R) and subsequent Ca2+ store depletion activate STIM (stromal interaction molecules) proteins, sensors of intraluminal Ca2+, which, in turn, open the Orai channels in plasma membrane. Downstream to this process could be activated TRPC (transient receptor potential-canonical) calcium permeable channels. Using single channel patch-clamp technique we found that a local Ca2+ entry through TRPC1 channels acti

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12

Gomez-Hernandez, Juan-Manuel, Walter Stühmer, and Anant B. Parekh. "Calcium dependence and distribution of calcium-activated chloride channels inXenopusoocytes." Journal of Physiology 502, no. 3 (1997): 569–74. http://dx.doi.org/10.1111/j.1469-7793.1997.569bj.x.

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13

Kourie, J. I., D. R. Laver, G. P. Ahern, and A. F. Dulhunty. "A calcium-activated chloride channel in sarcoplasmic reticulum vesicles from rabbit skeletal muscle." American Journal of Physiology-Cell Physiology 270, no. 6 (1996): C1675—C1686. http://dx.doi.org/10.1152/ajpcell.1996.270.6.c1675.

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A Ca(2+)-activated Cl- channel is described in sarcoplasmic reticulum (SR) enriched vesicles of skeletal muscle incorporated into lipid bilayers. Small chloride (SCl) channels (n = 20) were rapidly and reversibly activated when cis- (cytoplasmic) [Ca2+] was increased above 10(-7) M, with trans-(luminal) [Ca2+] at either 10(-3) or 10(-7) M. The open probability of single channels increased from zero when cis-[Ca2+] was 10(-7) M to 0.61 +/- 0.12 when [Ca2+] was 10(-4) M. High- and low-conductance levels in single-channel activity were activated at different cis-[Ca2+]. Channel openings to the ma

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14

Tang, Xiang D., Heather Daggett, Markus Hanner, et al. "Oxidative Regulation of Large Conductance Calcium-Activated Potassium Channels." Journal of General Physiology 117, no. 3 (2001): 253–74. http://dx.doi.org/10.1085/jgp.117.3.253.

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Reactive oxygen/nitrogen species are readily generated in vivo, playing roles in many physiological and pathological conditions, such as Alzheimer's disease and Parkinson's disease, by oxidatively modifying various proteins. Previous studies indicate that large conductance Ca2+-activated K+ channels (BKCa or Slo) are subject to redox regulation. However, conflicting results exist whether oxidation increases or decreases the channel activity. We used chloramine-T, which preferentially oxidizes methionine, to examine the functional consequences of methionine oxidation in the cloned human Slo (hS

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15

Eggermont, J. "Calcium-activated Chloride Channels: (Un)known, (Un)loved?" Proceedings of the American Thoracic Society 1, no. 1 (2004): 22–27. http://dx.doi.org/10.1513/pats.2306010.

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16

Kurtz, A. "Do Calcium-Activated Chloride Channels Control Renin Secretion?" Physiology 5, no. 2 (1990): 43–46. http://dx.doi.org/10.1152/physiologyonline.1990.5.2.43.

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The rate of renin secretion from renal juxtaglomerular epithelioid cells appears to be inversely correlated to intracellular Ca activity. Such a dependency of renin secretion on Ca activity could be controlled by Ca-activated Cl channels that may be involved in the volume control of juxtaglomerular cells.

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17

Kuan, Ai-Seon, Yu-Li Ni, and Tsung-Yu Chen. "Electrophysiological Properties of TMEM16A Calcium-Activated Chloride Channels." Biophysical Journal 106, no. 2 (2014): 145a. http://dx.doi.org/10.1016/j.bpj.2013.11.838.

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18

Mercer, A. J., K. Rabl, G. E. Riccardi, N. C. Brecha, S. L. Stella, and W. B. Thoreson. "Location of Release Sites and Calcium-Activated Chloride Channels Relative to Calcium Channels at the Photoreceptor Ribbon Synapse." Journal of Neurophysiology 105, no. 1 (2011): 321–35. http://dx.doi.org/10.1152/jn.00332.2010.

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Vesicle release from photoreceptor ribbon synapses is regulated by L-type Ca2+ channels, which are in turn regulated by Cl− moving through calcium-activated chloride [Cl(Ca)] channels. We assessed the proximity of Ca2+ channels to release sites and Cl(Ca) channels in synaptic terminals of salamander photoreceptors by comparing fast (BAPTA) and slow (EGTA) intracellular Ca2+ buffers. BAPTA did not fully block synaptic release, indicating some release sites are <100 nm from Ca2+ channels. Comparing Cl(Ca) currents with predicted Ca2+ diffusion profiles suggested that Cl(Ca) and Ca2+ channels

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19

Ackerman, M. J., K. D. Wickman, and D. E. Clapham. "Hypotonicity activates a native chloride current in Xenopus oocytes." Journal of General Physiology 103, no. 2 (1994): 153–79. http://dx.doi.org/10.1085/jgp.103.2.153.

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Xenopus oocytes are frequently utilized for in vivo expression of cellular proteins, especially ion channel proteins. A thorough understanding of the endogenous conductances and their regulation is paramount for proper characterization of expressed channel proteins. Here we detail a novel chloride current (ICl.swell) responsive to hypotonicity in Xenopus oocytes using the two-electrode voltage clamp technique. Reducing the extracellular osmolarity by 50% elicited a calcium-independent chloride current having an anion conductivity sequence identical with swelling-induced chloride currents obser

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20

Mangel, A. W., L. Scott, and R. A. Liddle. "Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 270, no. 2 (1996): G287—G290. http://dx.doi.org/10.1152/ajpgi.1996.270.2.g287.

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To examine the role of calcium channels in depolarization-activated cholecystokinin (CCK) release, studies were performed in an intestinal CCK-secreting cell line, STC-1. Blockade of potassium channels with barium chloride (5 mM) increased the release of CCK by 374.6 +/- 46.6% of control levels. Barium-induced secretion was inhibited by the L-type calcium-channel blocker, nicardipine. Nicardipine (10(-9)-10(-5) M) produced a dose-dependent inhibition in barium-stimulated secretion with a half-maximal inhibition (IC50) value of 0.1 microM. A second L-type calcium-channel blocker, diltiazem (10(

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21

Jensen, B. L., P. Ellekvist, and O. Skott. "Chloride is essential for contraction of afferent arterioles after agonists and potassium." American Journal of Physiology-Renal Physiology 272, no. 3 (1997): F389—F396. http://dx.doi.org/10.1152/ajprenal.1997.272.3.f389.

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A depolarizing chloride efflux has been suggested to activate voltage-dependent calcium channels in renal afferent arteriolar smooth muscle cells in response to vasoconstrictors. To test this proposal, rabbit afferent arterioles were microperfused, and the contractile dose responses to norepinephrine, angiotensin II (ANG II), and potassium were measured after chloride depletion and compared with controls. Chloride depletion did not change arteriolar diameters, but the response to norepinephrine was markedly reduced when chloride was substituted with gluconate (n = 6) or isethionate (n = 6). Re

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22

Elorza-Vidal, Xabier, Héctor Gaitán-Peñas, and Raúl Estévez. "Chloride Channels in Astrocytes: Structure, Roles in Brain Homeostasis and Implications in Disease." International Journal of Molecular Sciences 20, no. 5 (2019): 1034. http://dx.doi.org/10.3390/ijms20051034.

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Astrocytes are the most abundant cell type in the CNS (central nervous system). They exert multiple functions during development and in the adult CNS that are essential for brain homeostasis. Both cation and anion channel activities have been identified in astrocytes and it is believed that they play key roles in astrocyte function. Whereas the proteins and the physiological roles assigned to cation channels are becoming very clear, the study of astrocytic chloride channels is in its early stages. In recent years, we have moved from the identification of chloride channel activities present in

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23

Zamoyski, V. L., E. V. Bovina, and V. V. Grigoriev. "Properties of Calcium-Activated Chloride Currents in Rat Purkinje Cerebellum Neurons." Biomedical Chemistry: Research and Methods 1, no. 3 (2018): e00034. http://dx.doi.org/10.18097/bmcrm00034.

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The presence of calcium-activated chloride current was shown using on freshly isolated rat Purkinje cerebellum neiurones and the pacth-clamp method in the whole-cell configuration. Chloride currents appeared in sodium-free external solution and reversibly disappeared in chloride-free or calcium-free external solution. Replacing of K+ ions (120 mM) to Cs+ ions in micropipette (120 mM) show the chloride currents even with 140 mM Na+ in external solution. This current was blocked to 80–100% by nifluminic acid (25–100 ΜM). It was found out that well known blockers of potassium channels tetraethyla

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24

Forrest, Abigail S., Talia C. Joyce, Marissa L. Huebner, et al. "Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension." American Journal of Physiology-Cell Physiology 303, no. 12 (2012): C1229—C1243. http://dx.doi.org/10.1152/ajpcell.00044.2012.

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Pulmonary artery smooth muscle cells (PASMCs) are more depolarized and display higher Ca2+ levels in pulmonary hypertension (PH). Whether the functional properties and expression of Ca2+-activated Cl− channels (ClCa), an important excitatory mechanism in PASMCs, are altered in PH is unknown. The potential role of ClCa channels in PH was investigated using the monocrotaline (MCT)-induced PH model in the rat. Three weeks postinjection with a single dose of MCT (50 mg/kg ip), the animals developed right ventricular hypertrophy (heart weight measurements) and changes in pulmonary arterial flow (pu

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25

Flores, C. A., L. P. Cid, F. V. Sepúlveda, and M. I. Niemeyer. "TMEM16 proteins: the long awaited calcium-activated chloride channels?" Brazilian Journal of Medical and Biological Research 42, no. 11 (2009): 993–1001. http://dx.doi.org/10.1590/s0100-879x2009005000028.

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26

Pifferi, Simone. "Permeation Mechanisms in the TMEM16B Calcium-Activated Chloride Channels." PLOS ONE 12, no. 1 (2017): e0169572. http://dx.doi.org/10.1371/journal.pone.0169572.

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27

Ni, Yu-Li, Ai-Seon Kuan, and Tsung-Yu Chen. "Activation and Inhibition of TMEM16A Calcium-Activated Chloride Channels." PLoS ONE 9, no. 1 (2014): e86734. http://dx.doi.org/10.1371/journal.pone.0086734.

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28

Salzer, Isabella, and Stefan Boehm. "Calcium-activated chloride channels: Potential targets for antinociceptive therapy." International Journal of Biochemistry & Cell Biology 111 (June 2019): 37–41. http://dx.doi.org/10.1016/j.biocel.2019.04.006.

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29

Hoffmann, Else Kay, Niels Bjerre Holm, and Ian Henry Lambert. "Functions of volume-sensitive and calcium-activated chloride channels." IUBMB Life 66, no. 4 (2014): 257–67. http://dx.doi.org/10.1002/iub.1266.

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30

Jeng, Grace, Muskaan Aggarwal, Wei-Ping Yu, and Tsung-Yu Chen. "Activating Individual Subunits of TMEM16A Calcium-Activated Chloride Channels." Biophysical Journal 110, no. 3 (2016): 290a—291a. http://dx.doi.org/10.1016/j.bpj.2015.11.1571.

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31

Kuruma, Akinori, and H. Criss Hartzell. "Dynamics of calcium regulation of chloride currents inXenopus oocytes." American Journal of Physiology-Cell Physiology 276, no. 1 (1999): C161—C175. http://dx.doi.org/10.1152/ajpcell.1999.276.1.c161.

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Ca-activated Cl currents are widely expressed in many cell types and play diverse and important physiological roles. The Xenopus oocyte is a good model system for studying the regulation of these currents. We previously showed that inositol 1,4,5-trisphosphate (IP3) injection into Xenopus oocytes rapidly elicits a noninactivating outward Cl current ( I Cl1-S) followed several minutes later by the development of slow inward ( I Cl2) and transient outward ( I Cl1-T) Cl currents. In this paper, we investigate whether these three currents are mediated by the same or different Cl channels. Outward

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32

Jan, Lily. "Contribution of Potassium Channels and Calcium-Activated Chloride Channels to Neuronal Signaling." Biophysical Journal 104, no. 2 (2013): 196a. http://dx.doi.org/10.1016/j.bpj.2012.11.1104.

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33

Hao, Feng, Yi Ju Hou, Chen Zhao, et al. "Expression Clone of TMEM16A as a Calcium-Activated Chloride Channels in CHO Cells." Advanced Materials Research 709 (June 2013): 832–35. http://dx.doi.org/10.4028/www.scientific.net/amr.709.832.

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There is compelling evidence that TMEM16A fuctions as calcium-activated chloride channels (CaCCS), which was discovered by three independent labs in 2008 after Calcium-activated chloride channel current was first recorded in the 1980s. CaCCs are involved in many physiological processes, including transepithelial fluid secretion, smooth muscle contraction , sensory signal transduction and others. CaCCs are considers as potential drug therapy of hypertension, secretoy diarrheas, neuropathic pain, asthma, cystic fibrosis and certain tumors. In our previous study, TMEM16A with green fluorescence p

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34

KOTLIKOFF, MICHAEL I, and YONG-XIAO WANG. "Calcium Release and Calcium-Activated Chloride Channels in Airway Smooth Muscle Cells." American Journal of Respiratory and Critical Care Medicine 158, supplement_2 (1998): S109—S114. http://dx.doi.org/10.1164/ajrccm.158.supplement_2.13tac600.

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35

Vocke, Kerstin, Kristin Dauner, Anne Hahn, et al. "Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels." Journal of General Physiology 142, no. 4 (2013): 381–404. http://dx.doi.org/10.1085/jgp.201311015.

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Calcium-dependent chloride channels serve critical functions in diverse biological systems. Driven by cellular calcium signals, the channels codetermine excitatory processes and promote solute transport. The anoctamin (ANO) family of membrane proteins encodes three calcium-activated chloride channels, named ANO 1 (also TMEM16A), ANO 2 (also TMEM16B), and ANO 6 (also TMEM16F). Here we examined how ANO 1 and ANO 2 interact with Ca2+/calmodulin using nonstationary current analysis during channel activation. We identified a putative calmodulin-binding domain in the N-terminal region of the channel

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36

Xu, Yanfang, Pei Hong Dong, Zhao Zhang, Gias Uddin Ahmmed, and Nipavan Chiamvimonvat. "Presence of a calcium-activated chloride current in mouse ventricular myocytes." American Journal of Physiology-Heart and Circulatory Physiology 283, no. 1 (2002): H302—H314. http://dx.doi.org/10.1152/ajpheart.00044.2002.

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The properties of several components of outward K+ currents, including the pharmacological and kinetics profiles as well as the respective molecular correlates, have been identified in mouse cardiac myocytes. Surprisingly little is known with regard to the Ca2+-activated ionic currents. We studied the Ca2+-activated transient outward currents in mouse ventricular myocytes. We have identified a 4-aminopyridine (4-AP)- and tetraethyl ammonium-resistant transient outward current that is Ca2+ dependent. The current is carried by Cl−and is critically dependent on Ca2+ influx via voltage-gated Ca2+

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37

Richards, N. W., R. J. Lowy, S. A. Ernst, and D. C. Dawson. "Two K+ channel types, muscarinic agonist-activated and inwardly rectifying, in a Cl- secretory epithelium: the avian salt gland." Journal of General Physiology 93, no. 6 (1989): 1171–94. http://dx.doi.org/10.1085/jgp.93.6.1171.

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Patches of membrane on cells isolated from the nasal salt gland of the domestic duck typically contained two types of K+ channel. One was a large-conductance ("maxi") K+ channel which was activated by intracellular calcium and/or depolarizing membrane voltages, and the other was a smaller-conductance K+ channel which exhibited at least two conductance levels and displayed pronounced inward rectification. Barium blocked both channels, but tetraethylammonium chloride and quinidine selectively blocked the larger K+ channel. The large K+ channel did not appear to open under resting conditions but

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38

Amjad, Asma, Andres Hernandez-Clavijo, Simone Pifferi, et al. "Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons." Journal of General Physiology 145, no. 4 (2015): 285–301. http://dx.doi.org/10.1085/jgp.201411348.

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Pheromones are substances released from animals that, when detected by the vomeronasal organ of other individuals of the same species, affect their physiology and behavior. Pheromone binding to receptors on microvilli on the dendritic knobs of vomeronasal sensory neurons activates a second messenger cascade to produce an increase in intracellular Ca2+ concentration. Here, we used whole-cell and inside-out patch-clamp analysis to provide a functional characterization of currents activated by Ca2+ in isolated mouse vomeronasal sensory neurons in the absence of intracellular K+. In whole-cell rec

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39

Koumi, S., R. Sato, and T. Aramaki. "Characterization of the calcium-activated chloride channel in isolated guinea-pig hepatocytes." Journal of General Physiology 104, no. 2 (1994): 357–73. http://dx.doi.org/10.1085/jgp.104.2.357.

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Macroscopic and unitary currents through Ca(2+)-activated Cl- channels were examined in enzymatically isolated guinea-pig hepatocytes using whole-cell, excised outside-out and inside-out configurations of the patch-clamp technique. When K+ conductances were blocked and the intracellular Ca2+ concentration ([Ca2+]i) was set at 1 microM (pCa = 6), membrane currents were observed under whole-cell voltage-clamp conditions. The reversal potential of the current shifted by approximately 60 mV per 10-fold change in the external Cl- concentration. In addition, the current did not appear when Cl- was o

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40

Leblanc, Normand, Jonathan Ledoux, Sohag Saleh, et al. "Regulation of calcium-activated chloride channels in smooth muscle cells: a complex picture is emerging." Canadian Journal of Physiology and Pharmacology 83, no. 7 (2005): 541–56. http://dx.doi.org/10.1139/y05-040.

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Calcium-activated chloride channels (ClCa) are ligand-gated anion channels as they have been shown to be activated by a rise in intracellular Ca2+ concentration in various cell types including cardiac, skeletal and vascular smooth muscle cells, endothelial and epithelial cells, as well as neurons. Because ClCa channels are normally closed at resting, free intracellular Ca2+ concentration (~100 nmol/L) in most cell types, they have generally been considered excitatory in nature, providing a triggering mechanism during signal transduction for membrane excitability, osmotic balance, transepitheli

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41

Morel, Jean-Luc, Nathalie Mokrzycki, Guy Lippens, Hervé Drobecq, Pierre Sautière, and Michel Hugues. "Characterization of a Family of Scorpion Toxins Modulating Ca2+-Activated Cl− Current in Vascular Myocytes." Toxins 14, no. 11 (2022): 780. http://dx.doi.org/10.3390/toxins14110780.

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The pharmacology of calcium-activated chloride current is not well developed. Peptides from scorpion venom present potent pharmacological actions on ionic conductance used to characterize the function of channels but can also be helpful to develop organic pharmacological tools. Using electrophysiological recording coupled with calcium measurement, we tested the potent effect of peptides extracted from Leuirus quinquestratus quinquestratus venom on the calcium-activated chloride current expressed in smooth muscle cells freshly dissociated from rat portal veins. We identified one peptide which s

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42

Loewen, Matthew E., Sherif E. Gabriel, and George W. Forsyth. "The calcium-dependent chloride conductance mediator pCLCA1." American Journal of Physiology-Cell Physiology 283, no. 2 (2002): C412—C421. http://dx.doi.org/10.1152/ajpcell.00477.2001.

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The regulatory behavior, inhibitor sensitivity, and properties of the whole cell chloride conductance observed in cells expressing the cDNA coding for a chloride conductance mediator isoform of the CLCA gene family, pCLCA1, have been studied. Common C-kinase consensus phosphorylation sites between pCLCA1 and the closely related human isoform hCLCA1 are consistent with a role for calcium in channel activation. Both channels are activated rapidly on exposure to the calcium ionophore ionomycin. Direct involvement of calcium in the activation of pCLCA1 was supported by the finding that treatment w

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O'Driscoll, Kate E., William J. Hatton, Heather R. Burkin, Normand Leblanc, and Fiona C. Britton. "Expression, localization, and functional properties of Bestrophin 3 channel isolated from mouse heart." American Journal of Physiology-Cell Physiology 295, no. 6 (2008): C1610—C1624. http://dx.doi.org/10.1152/ajpcell.00461.2008.

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Bestrophins are a novel family of proteins that encode calcium-activated chloride channels. In this study we establish that Bestrophin transcripts are expressed in the mouse and human heart. Native mBest3 protein expression and localization in heart was demonstrated by using a specific polyclonal mBest3 antibody. Immunostaining of isolated cardiac myocytes indicates that mBest3 is present at the membrane. Using the patch-clamp technique, we characterized the biophysical and pharmacological properties of mBest3 cloned from heart. Whole cell chloride currents were evoked in both HEK293 and COS-7

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Keating, N., and L. R. Quinlan. "Small conductance potassium channels drive ATP-activated chloride secretion in the oviduct." American Journal of Physiology-Cell Physiology 302, no. 1 (2012): C100—C109. http://dx.doi.org/10.1152/ajpcell.00503.2010.

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The molecular mechanisms controlling fluid secretion within the oviduct have yet to be determined. As in other epithelia, both secretory and absorptive pathways are likely to work in tandem to drive appropriate ionic movement to support fluid movement across the oviduct epithelium. This study explored the role of potassium channels in basolateral extracellular ATP (ATPe)-stimulated ion transport in bovine oviduct epithelium using the Ussing chamber short-circuit current ( ISC) technique. Basal ISC in bovine oviduct epithelium comprises both chloride secretion and sodium absorption and was inhi

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Arreola, J., J. E. Melvin, and T. Begenisich. "Activation of calcium-dependent chloride channels in rat parotid acinar cells." Journal of General Physiology 108, no. 1 (1996): 35–47. http://dx.doi.org/10.1085/jgp.108.1.35.

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The Ca2+ and voltage dependence of Ca(2+)-activated Cl- currents in rat parotid acinar cells was examined with the whole-cell patch clamp technique. Acinar cells were dialyzed with buffered free Ca2+ concentrations ([Ca2+]i) from &lt; 1 nM to 5 microM. Increasing [Ca2+]i induced an increase in Cl- current at all membrane potentials. In cells dialyzed with [Ca2+]i &gt; 25 nM, depolarizing test pulses activated a Cl- current that was composed of an instantaneous and a slow monoexponential component. The steady-state current-voltage relationship showed outward rectification at low [Ca2+]i

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Nilius, B., J. Prenen, G. Szücs, et al. "Calcium-activated chloride channels in bovine pulmonary artery endothelial cells." Journal of Physiology 498, no. 2 (1997): 381–96. http://dx.doi.org/10.1113/jphysiol.1997.sp021865.

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Cruz-Rangel, Silvia, José J. De Jesús-Pérez, Juan A. Contreras-Vite, Patricia Pérez-Cornejo, H. Criss Hartzell, and Jorge Arreola. "Gating modes of calcium-activated chloride channels TMEM16A and TMEM16B." Journal of Physiology 593, no. 24 (2015): 5283–98. http://dx.doi.org/10.1113/jp271256.

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Dalati, S., and M. L. Day. "124. THE ROLE OF CALCIUM ACTIVATED CHLORIDE CHANNELS AT FERTILISATION." Reproduction, Fertility and Development 22, no. 9 (2010): 42. http://dx.doi.org/10.1071/srb10abs124.

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Sperm entry into the oocyte triggers a signal transduction pathway resulting in intracellular calcium [Ca2+] oscillations that coincide with hyperpolarisations in membrane potential (Em). Ca2+ oscillations have been previously described and found to be important for embryo development, yet Em hyperpolarisations and their importance at fertilisation still remains unclear. Thimerosal, a sulfhydryl reagent, has been shown to mimic the physiological changes caused by sperm following fertilisation. It does this by direct sensitisation of the inositol 1,4,5-triphosphate receptor-1 to basal levels of

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Sun, Yuyang, Lutz Birnbaumer, and Brij B. Singh. "TRPC1 regulates calcium‐activated chloride channels in salivary gland cells." Journal of Cellular Physiology 230, no. 11 (2015): 2848–56. http://dx.doi.org/10.1002/jcp.25017.

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Kamaleddin, Mohammad Amin. "Molecular, biophysical, and pharmacological properties of calcium-activated chloride channels." Journal of Cellular Physiology 233, no. 2 (2017): 787–98. http://dx.doi.org/10.1002/jcp.25823.

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