Relevant bibliographies by topics / Calcium Activated Potassium (BK) Channels

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Academic literature on the topic 'Calcium Activated Potassium (BK) Channels'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Calcium Activated Potassium (BK) Channels"

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Art, J. J., Y. C. Wu, and R. Fettiplace. "The calcium-activated potassium channels of turtle hair cells." Journal of General Physiology 105, no. 1 (1995): 49–72. http://dx.doi.org/10.1085/jgp.105.1.49.

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A major factor determining the electrical resonant frequency of turtle cochlear hair cells is the time course of the Ca-activated K current (Art, J. J., and R. Fettiplace. 1987. Journal of Physiology. 385:207-242). We have examined the notion that this time course is dictated by the K channel kinetics by recording single Ca-activated K channels in inside-out patches from isolated cells. A hair cell's resonant frequency was estimated from its known correlation with the dimensions of the hair bundle. All cells possess BK channels with a similar unit conductance of approximately 320 pS but with d
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Zang, Kai, Yuwen Zhang, Jie Hu, and Yun Wang. "The Large Conductance Calcium- and Voltage-activated Potassium Channel (BK) and Epilepsy." CNS & Neurological Disorders - Drug Targets 17, no. 4 (2018): 248–54. http://dx.doi.org/10.2174/1871527317666180404104055.

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Background & Objective: The large conductance, calcium- and voltage-activated potassium channels (BK) are widely distributed channel proteins which exist in virtually every cell type of mammals and function to influence membrane excitability and Ca2+ signaling. BK channels can be activated by the increase of the intracellular Ca2+ concentration, a consequence of neuronal excitation, and then terminate the action potential with the outward K+ flux. Moreover, after-hyperpolarization induced by BK channels closes Cav channels and thus precludes excessive Ca2+ influx. Considering this negative
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Chen, Xinzhe. "Research progress on calcium-activated potassium ion channels." Theoretical and Natural Science 62, no. 1 (2024): 160–65. http://dx.doi.org/10.54254/2753-8818/62/20241522.

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Abstract. Potassium ion channels are diverse and widely distributed, playing a key role in a variety of physiological and pathological processes. According to the size of the conductance, they can be divided into large conductive calcium activated potassium channel (BK channel), medium conductive calcium activated potassium channel (IK channel) and small conductive calcium activated potassium channel (SK channel). In recent years, remarkable progress has been made in studying these three ion channels, and a series of therapeutic drugs have emerged. According to the single channel conductance,
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Lara, Jesús, Juan José Acevedo, and Carlos G. Onetti. "Large-Conductance Ca2+-Activated Potassium Channels in Secretory Neurons." Journal of Neurophysiology 82, no. 3 (1999): 1317–25. http://dx.doi.org/10.1152/jn.1999.82.3.1317.

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Large-conductance Ca2+-activated K+ channels (BK) are believed to underlie interburst intervals and contribute to the control of hormone release in several secretory cells. In crustacean neurosecretory cells, Ca2+entry associated with electrical activity could act as a modulator of membrane K+ conductance. Therefore we studied the contribution of BK channels to the macroscopic outward current in the X-organ of crayfish, and their participation in electrophysiological activity, as well as their sensitivity toward intracellular Ca2+, ATP, and voltage, by using the patch-clamp technique. The BK c
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McKay, M. C., S. I. Dworetzky, N. A. Meanwell, et al. "Opening of large-conductance calcium-activated potassium channels by the substituted benzimidazolone NS004." Journal of Neurophysiology 71, no. 5 (1994): 1873–82. http://dx.doi.org/10.1152/jn.1994.71.5.1873.

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1. We used electrophysiological techniques to examine the effects of 5-trifluoromethyl-1-(5-chloro-2-hydroxyphenyl)-1,3-dihydro-2H-benzimidaz ole- 2-one (NS004) on large-conductance calcium-activated potassium (BK) channels. 2. We used recordings from excised membrane patches (cell-attached and inside-out single-channel configurations) and whole-cell patch-clamp recordings to examine the effects of NS004 on single BK channels and whole-cell outward currents, respectively, in rat GH3 clonal pituitary tumor cells. We also tested NS004 on voltage-clamped BK channels isolated from rat brain plasma
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Pérez, Guillermo J., Mayurika Desai, Seth Anderson, and Fabiana S. Scornik. "Large-conductance calcium-activated potassium current modulates excitability in isolated canine intracardiac neurons." American Journal of Physiology-Cell Physiology 304, no. 3 (2013): C280—C286. http://dx.doi.org/10.1152/ajpcell.00148.2012.

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We studied principal neurons from canine intracardiac (IC) ganglia to determine whether large-conductance calcium-activated potassium (BK) channels play a role in their excitability. We performed whole cell recordings in voltage- and current-clamp modes to measure ion currents and changes in membrane potential from isolated canine IC neurons. Whole cell currents from these neurons showed fast- and slow-activated outward components. Both current components decreased in the absence of calcium and following 1–2 mM tetraethylammonium (TEA) or paxilline. These results suggest that BK channels under
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Maqoud, Fatima, Michela Cetrone, Antonietta Mele, and Domenico Tricarico. "Molecular structure and function of big calcium-activated potassium channels in skeletal muscle: pharmacological perspectives." Physiological Genomics 49, no. 6 (2017): 306–17. http://dx.doi.org/10.1152/physiolgenomics.00121.2016.

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The large-conductance Ca2+-activated K+ (BK) channel is broadly expressed in various mammalian cells and tissues such as neurons, skeletal muscles (sarco-BK), and smooth muscles. These channels are activated by changes in membrane electrical potential and by increases in the concentration of intracellular calcium ion (Ca2+). The BK channel is subjected to many mechanisms that add diversity to the BK channel α-subunit gene. These channels are indeed subject to alternative splicing, auxiliary subunits modulation, posttranslational modifications, and protein-protein interactions. BK channels can
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Starrett Jr., John E., Steven I. Dworetzky, and Valentin K. Gribkoff. "Modulators of Large-Conductance Calcium-Activated Potassium (BK) Channels as Potential Therapeutic Targets." Current Pharmaceutical Design 2, no. 4 (1996): 413–28. http://dx.doi.org/10.2174/1381612802666220926184514.

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BK channels are large conductance calcium-activated potassium channels that are found in many tissues, including excitable cells such as myocytes and neurons. The high conductance and dependence on calcium of BK channels suggests that modulation of these channels may have a pronounced effect on tissues in which they are expressed. Within the past four years, a variety of small molecules and natural product-derived modulators of BK channels have been described. This review will focus on compounds which are openers and blockers of BK channels and their therapeutic potential, with introductory se
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Feng, Xinghua, Zhuangzhuang Zhao, Qian Li, and Zhiyong Tan. "Lysosomal Potassium Channels: Potential Roles in Lysosomal Function and Neurodegenerative Diseases." CNS & Neurological Disorders - Drug Targets 17, no. 4 (2018): 261–66. http://dx.doi.org/10.2174/1871527317666180202110717.

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Background & Objective: The lysosome is a membrane-enclosed organelle widely found in every eukaryotic cell. It has been deemed as the stomach of the cells. Recent studies revealed that it also functions as an intracellular calcium store and is a platform for nutrient-dependent signal transduction. Similar with the plasma membrane, the lysosome membrane is furnished with various proteins, including pumps, ion channels and transporters. So far, two types of lysosomal potassium channels have been identified: large-conductance and Ca2+-activated potassium channel (BK) and TMEM175. TMEM175 has
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Hunsberger, Michael S., and Michelle Mynlieff. "BK potassium currents contribute differently to action potential waveform and firing rate as rat hippocampal neurons mature in the first postnatal week." Journal of Neurophysiology 124, no. 3 (2020): 703–14. http://dx.doi.org/10.1152/jn.00711.2019.

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This work describes the early developmental trends of large-conductance calcium-activated potassium (BK) channel activity. Early developmental trends in expression of BK channels, both total expression and relative isoform expression, have been previously reported, but little work describes the effect of these changes in expression patterns on excitability. Here, we show that early changes in BK channel expression patterns lead to changes in the role of BK channels in determining the action potential waveform and neuronal excitability.
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Dissertations / Theses on the topic "Calcium Activated Potassium (BK) Channels"

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Macdonald, Stephen Hsiao-Feng. "Alternative splicing of large-conductance calcium- and voltage-activated potassium (BK) channels." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/29237.

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The aim of this thesis was to test the hypotheses that: i) alternative splicing may control subcellular localisation of BK channel α-subunits and ii) splice variants are differentially expressed in tissues, using the murine BK channel as the model system. To address whether alternative splice variants may be trafficked specifically to different subcellular compartments, epitope-tagged BK channel splice variants were expressed in a mammalian epithelial and endocrine cells. STREX and ZERO variants, in contrast to splice variant Δe23 that is C-terminally truncated, efficiently trafficked to the p
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Krishnamoorthy, Gayathri. "MECHANISM OF CALCIUM DEPENDENT GATING OF BKCa CHANNELS: RELATING PROTEIN STRUCTURE TO FUNCTION." online version, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1144444855.

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Apolinar, Sanrda. "BK channel involvement in beta-adrenergic relaxation of murine tracheal smooth muscle a thesis /." San Antonio : UTHSC, 2008. http://learningobjects.library.uthscsa.edu/cdm4/item_viewer.php?CISOROOT=/theses&CISOPTR=32&CISOBOX=1&REC=3.

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Coghill, Lorraine Sheila. "Regulation of large conductance calcium- and voltage-activated potassium (BK) channel splice variants by protein kinase A." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23309.

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Wynne, Patricia M. "Ethanol Sensitivity and Tolerance of Rat Neuronal BK Channels: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/399.

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BK channels are well studied targets of acute ethanol action. They play a prominent role in neuronal excitability and have been shown to play a significant role in behavioral ethanol tolerance in invertebrates. The focus of my work centers on the effects of alcohol on the BK channel and comprises studies that examine how subcellular location affects acute ethanol sensitivity and how duration of acute alcohol exposure impacts the development of rapid tolerance. My results also provide potential mechanisms which underlie acute sensitivity and rapid tolerance. I first explore BK channel sensitivi
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Feinberg-Zadek, Paula Leslie. "Alcohol Modulation of Human BK Channels Evidence for β-Subunit Dependent Plasticity in Functional Ethanol Tolerance: A Dissertation". eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/195.

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Alcoholism is responsible for more than 6% of deaths internationally per annum. The development of acute tolerance to ethanol (EtOH) is a critical component of alcoholism. Previous studies identified large conductance calcium-activated potassium (BK) channels as potential EtOH targets in a variety of species and cells. In order to elucidate mechanisms underlying tolerance development, I used inside-out patch clamp techniques to measure EtOH induced changes in channel activity (measured as open probability) of hSlo, hSlo+β1, and hSlo+β4 channels exogenously expressed in HEK 293 cells. I show th
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Georgiou, Panayiotis Paulou. "Calcium-activated potassium-channels in mammalian eggs." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/29774.

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Millership, Joanne Ella. "Regulation and function of calcium-activated potassium channels." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503016.

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Bi, Danlei. "Palmitoylation of large conductance voltage- and calcium-dependent potassium (BK) channels." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/17286.

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S-palmitoylation is a reversible post-translational lipid modification of proteins by adding a 16-carbon palmitate onto a cysteine residue. Palmitoylation has been shown to control the trafficking and function of many signalling proteins including ion channels. In this Thesis, palmitoylation is shown to control both the plasma membrane expression and gating properties of large conductance calcium- and voltage- dependent potassium (BK) channels. The BK channel is assembled from four pore-forming α-subunits. Each α-subunit contains seven transmembrane domains (S0-S6), with an extracellular N-ter
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D'hoedt, Dieter. "Structure-function analyses of small-conductance, calcium-activated potassium channels." Diss., [S.l.] : [s.n.], 2005. http://edoc.ub.uni-muenchen.de/archive/00006036.

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Books on the topic "Calcium Activated Potassium (BK) Channels"

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Slimp, Jefferson C. Neurophysiology of Multiple Sclerosis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199341016.003.0003.

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Any discussion of the pathomechanisms and treatments of MS benefits from an understanding of the physiology of the neuronal membrane and the action potential. Neurons and glia, are important for signal propagation, synaptic function, and neural development. The neuronal cell membrane, maintains different ionic environments inside and outside the cell, separating charge across the membrane and facilitating electrical excitability. Ion channels allow flow of sodium, potassium, and calcium ions across the membrane at selected times. At rest, potassium ion efflux across the membrane establishes th
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Book chapters on the topic "Calcium Activated Potassium (BK) Channels"

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Kume, Hiroaki. "Large-Conductance Calcium-Activated Potassium Channels." In Calcium Signaling In Airway Smooth Muscle Cells. Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-01312-1_4.

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Kaczorowski, Gregory J., and Thomas R. Jones. "High Conductance Calcium-Activated Potassium Channels." In Airways Smooth Muscle: Peptide Receptors, Ion Channels and Signal Transduction. Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7362-8_8.

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Lingle, Christopher J., Christopher R. Solaro, Murali Prakriya, and Jiu Ping Ding. "Calcium-Activated Potassium Channels in Adrenal Chromaffin Cells." In Ion Channels. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4899-1775-1_7.

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Blanc, Eric, and Hervé Darbon. "Pharmacology of Small-Conductance, Calcium-Activated K+Channels." In Potassium Channels in Cardiovascular Biology. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1303-2_14.

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Zhang, Miao, and Heike Wulff. "Small-Conductance Calcium-Activated Potassium (SK) Channels." In Textbook of Ion Channels Volume II. CRC Press, 2023. http://dx.doi.org/10.1201/9781003096276-8.

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Adams, Paul R., David A. Brown, Andrew Constanti, Robert B. Clark, and Leslie Satin. "Calcium-Activated Potassium Channels in Bullfrog Sympathetic Ganglion Cells." In Calcium in Biological Systems. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2377-8_21.

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Bartschat, D. K., and M. P. Blaustein. "Calcium-Activated Potassium Channels in Presynaptic Nerve Terminals." In Topics in the Neurosciences. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2307-5_6.

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Kemp, Paul J., Chris Peers, and Anthony Lewis. "Oxygen Sensing by Human Recombinant Large Conductance,Calcium-activated Potassium Channels." In Advances in Experimental Medicine and Biology. Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9280-2_27.

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Kemp, Paul J., Matthew E. Hartness, and Chris Peers. "Oxygen Sensing by Human Recombinant Large Conductance, Calcium-activated Potassium Channels." In Advances in Experimental Medicine and Biology. Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9280-2_73.

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Wolff, Daniel, Cecilia Vergara, Ximena Cecchi, and Ramon Latorre. "Characterization of Large-Unitary-Conductance Calcium-Activated Potassium Channels in Planar Lipid Bilayers." In Ionic Channels in Cells and Model Systems. Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5077-4_20.

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Conference papers on the topic "Calcium Activated Potassium (BK) Channels"

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Vang, Alexander, Anlong Li, and Gaurav Choudhary. "Effect Of Large Conductance Calcium-Activated Potassium (BK) Channel Opener, NS1619, On Normoxic And Hypoxic Pulmonary Vasculature." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a4833.

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Pe�aranda, Angelina, Blas Echebarria, Enrique Alvarez-Lacalle, and Inmaculada R. Cantalapiedra. "Effects of Small Conductance Calcium Activated Potassium Channels in Cardiac Myocytes." In 2017 Computing in Cardiology Conference. Computing in Cardiology, 2017. http://dx.doi.org/10.22489/cinc.2017.308-050.

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Gupta, Bindiya, Puja Kumari, Shalini Rajaram, Rajarshi Kar, Priyanka Gogoi, and Sandhya Jain. "2022-RA-366-ESGO Calcium activated potassium channels (KCNMA1) as biomarker of pre invasive and invasive cervical cancer." In ESGO 2022 Congress. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-esgo.866.

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Lo, Wing-Yee, Corinna Mohr, Friederike Steudel, et al. "Abstract 2030: The role of genetic variation in calcium-activated potassium channels in breast cancer patients treated with tamoxifen." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2030.

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Yim, Peter, George Gallos, Yi Zhang, and Charles W. Emala. "Concomitant Blockade Of Calcium-Activated Chloride Channels (CACC) And Sodium Potassium Chloride Cotransporter (NKCC) Attenuates Acetylcholine Contractions In Human Airway Smooth Muscle." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a6033.

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