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Dissertations / Theses on the topic 'Calcium channels – Animal models'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

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1

Jeffs, Graham J. "The effect of sodium/calcium exchanger 3 (NCX3) knockout on neuronal survival following global cerebral ischaemia in mice." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0063.

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Cerebral ischaemia is a leading cause of disability and death world-wide. The only effective treatments are thrombolytic therapy (plasminogen activator; tPA) and hypothermia (33?C). However, tPA has limited clinical application due to its short therapeutic time window and its specific application in thrombo-embolic stroke. Moderate hypothermia (33?C) is only being used following cardiac arrest in comatose survivors. Hence more treatments are urgently required. The first step in developing new treatments is the identification and characterisation of a potential therapeutic target. Since brain d

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2

Diffley, Leonie. "Calcium regulation and ion channel remodelling in an animal model of heart failure." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493676.

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CHF is a complex disease that results in the remodelling of the heart at every level, from the gross anatomy down to the levels of the ion channel resulting in aberrant signalling and contractile dysfunction. The QT interval of the cardiac ECG is frequently increased in heart failure, suggesting ion channel remodelling which has proarrhythmic consequences. One of the aims of this study was to determine the changes that occur from the in vivo level, down to the level of the ion channel that may contribute to arrhythmogenesis.

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3

DeRemigio, Hilary. "Markov chain models of instantaneously coupled intracellular calcium channels." W&M ScholarWorks, 2008. https://scholarworks.wm.edu/etd/1539623334.

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Localized calcium elevations known as calcium puffs or sparks are cellular signals arising from cooperative activity of clusters of inositol 1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RyRs) located at calcium release sites on the endoplasmic or sarcoplasmic reticulum membrane. When Markov chain models of these intracellular calcium-regulated calcium channels are coupled via a mathematical representation of the calcium microdomain, simulated calcium release sites may exhibit the phenomenon of "stochastic calcium excitability" where the IP3Rs or RyRs open and close in a concer

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4

Calcraft, Peter James. "Two-pore channels and NAADP-dependent calcium signalling." Thesis, St Andrews, 2010. http://hdl.handle.net/10023/888.

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5

Muller, Yunhua Li 1963. "Developmentally regulated expression of the calcium-dependent potassium channel and calcium channels during maturation of the rat cerebellum." Diss., The University of Arizona, 1996. http://hdl.handle.net/10150/282231.

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Potassium channels govern the duration and frequency of excitable membrane events, and thus may regulate voltage-dependent signals that are important in neuronal development. This study assesses the developmental expression of two classes of K⁺ channels in vivo and in vitro in the rat cerebellum. In vivo, the level of mslo-related transcript for the Ca²⁺-dependent K⁺ channel (KCa) was shown by Northern analysis to be upregulated during development, whereas transcripts for delayed rectifier (KD) channels remained fairly constant. The same pattern of in vivo development was demonstrated with fun

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6

Matias, Madeleine Gundayao. "Animal calcium release-activated calcium (CRAC) channels are homologous and derived from the ubiquitous Cation Diffusion Facilitators." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p1453033.

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Thesis (M.S.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed June 25, 2008). Available via ProQuest Digital Dissertations. Includes bibliographical references (p. 48-51).

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7

Giannattasio, Bartolomeo. "Characterization of ATP receptors and voltage-dependent calcium ion channels in cardiovascular cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1060781044.

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8

Giblin, Kathryn Anne. "Is epilepsy a preventable disorder? New evidence from animal models." Yale University, 2010. http://ymtdl.med.yale.edu/theses/available/etd-03052010-144943/.

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Epilepsy accounts for 0.5% of the global burden of disease, and primary prevention of epilepsy represents one of the three 2007 NINDS Epilepsy Research Benchmarks. Efforts to understand and intervene in the process of epileptogenesis have yielded fruitful preventative strategies in animal models. This article reviews the current understanding of epileptogenesis, introduces the concept of a "critical period" for epileptogenesis, and examines strategies for epilepsy prevention in animal models of both acquired and genetic epilepsies. As proof of principle, we investigated whether early preventat

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9

Rakers, Cordula Marijke [Verfasser]. "The role of glial calcium changes in animal models of stroke / Cordula Marijke Rakers." Bonn : Universitäts- und Landesbibliothek Bonn, 2015. http://d-nb.info/1121105599/34.

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10

Kaurstad, Guri. "Cardiomyocyte function and calcium handling in animal models of inborn and aquired maximal oxygen uptake." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for sirkulasjon og bildediagnostikk, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-16549.

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Hjertemuskelcellefunksjon og kalsiumhåndtering i dyremodeller med medfødt og ervervet maksimalt oksygenopptak Hjerte-karsykdommer er i dag årsaken til flest dødsfall i Europa. Selv om det er kjent at et høyt maksimalt oksygenopptak kan virke beskyttende mot hjerte-karsykdom både hos friske og de med økt risiko, vil studier av de underliggende mekanismene bidra med verdifull informasjon til utvikling av fremtidige retningslinjer for behandling og forebygging av hjertekarsykdom. Maksimalt oksygenopptak er hos de fleste av oss avhengig av hjertets slagvolum som igjen bestemmes av hjertemuskelcel

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11

Li, Zhaoyang, and 李朝陽. "Novel strontium fortified calcium salt for enhancing bone formation: an in vitro and in vivo large animal modelstudy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39557108.

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12

Barrett, Curtis F. "Modulation of N-type Calcium Channels in Rat Superior Cervical Ganglion Neurons: A Dissertation." eScholarship@UMMS, 2001. https://escholarship.umassmed.edu/gsbs_diss/144.

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This thesis details my examination of several mechanisms for modulation of N-type calcium channels in neonatal rat superior cervical ganglion (SCG) neurons. The first part of this work characterizes cross-talk between two distinct mechanisms of modulation: readily-reversible inhibition induced by activation of heterotrimeric G-proteins (termed G-protein-mediated inhibition), and phosphorylation of the channel by protein kinase C (PKC). Data previously presented by other groups suggested that one effect of activating PKC is to prevent G-protein-mediated inhibition. The goal of this project was

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13

Schampel, Andrea [Verfasser], and Stefanie [Gutachter] Kürten. "Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis / Andrea Schampel ; Gutachter: Stefanie Kürten." Würzburg : Universität Würzburg, 2017. http://d-nb.info/1139641344/34.

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14

Danielsson, Christian. "Role of the hERG-channel in arrhythmia and teratogenicity studies in animal models and the human embryonic heart /." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-831-0/.

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15

Köth, Jessica [Verfasser]. "Cardiac L‐type calcium channels and expression of RGK proteins in mouse models associated with type 2 diabetes / Jessica Köth." Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/1170778097/34.

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16

Rahmati, Vahid, Knut Kirmse, Dimitrije Marković, Knut Holthoff, and Stefan J. Kiebel. "Inferring Neuronal Dynamics from Calcium Imaging Data Using Biophysical Models and Bayesian Inference." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-203385.

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Calcium imaging has been used as a promising technique to monitor the dynamic activity of neuronal populations. However, the calcium trace is temporally smeared which restricts the extraction of quantities of interest such as spike trains of individual neurons. To address this issue, spike reconstruction algorithms have been introduced. One limitation of such reconstructions is that the underlying models are not informed about the biophysics of spike and burst generations. Such existing prior knowledge might be useful for constraining the possible solutions of spikes. Here we describe, in a no

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17

Witczak, Carol A. "Regulation of coronary smooth muscle intracellular Ca²⁺ levels in porcine models of hyperlipidemia, diabetic dyslipidemia, and exercise training." free to MU Campus, others may purchase, 2003. http://www.lib.umi.com/cr/mo/fullcit?p3091979.

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18

Young, Lois-May. "Evaluation of polycyclic amines as modulators of calcium homeostasis in models of neurodegeneration / Young L." Thesis, North-West University, 2012. http://hdl.handle.net/10394/7591.

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Compromised calcium homeostasis in the central nervous system (CNS) is implicated as a major contributor in the pathology of neurodegeneration. Dysregulation of Ca2+ homeostasis initiates downstream Ca2+–dependent events that lead to apoptotic and/or necrotic cell death. Increases in the intracellular free calcium concentration ([Ca2+]i) may be the result of Ca2+ influx from the extracellular environment or Ca2+ release from intracellular Ca2+ stores such as the endoplasmic reticulum (ER). Influx from the extracellular environment is controlled predominantly by voltage gated calcium channels (

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19

Wynne, Patricia M. "Ethanol Sensitivity and Tolerance of Rat Neuronal BK Channels: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/399.

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BK channels are well studied targets of acute ethanol action. They play a prominent role in neuronal excitability and have been shown to play a significant role in behavioral ethanol tolerance in invertebrates. The focus of my work centers on the effects of alcohol on the BK channel and comprises studies that examine how subcellular location affects acute ethanol sensitivity and how duration of acute alcohol exposure impacts the development of rapid tolerance. My results also provide potential mechanisms which underlie acute sensitivity and rapid tolerance. I first explore BK channel sensitivi

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20

McCullough, Brendan J. "The deafwaddler mouse as a model for human hearing loss /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/10627.

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21

Kaizik, Stephan Martin. "Analysis of mouse models of insulin secretion disorders." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:4d44b68a-a0a0-4c92-8809-00ddbfe3e636.

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22

Korhonen, T. (Topi). "Mathematical modeling of the regulation, development and genetically engineered experimental models of cardiac excitation-contraction coupling." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514290756.

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Abstract Excitation-contraction coupling (ECC) is a process linking the electrical excitation of the muscle cell (myocyte) membrane to the contraction of the cell. In this study the possibilities of mathematical modeling were studied in current ECC research. Mathematical modeling was employed in two distinct ECC research areas, the enzymatic regulation of ECC and ECC during cardiac myocyte development. Despite the distinction, both of these are extremely complex biological systems characterized by diverse and partly contradictory reported experimental results, with a large part based on genet

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23

Ferreira, Juliana Cunha. "Efeito do carbonato de cálcio e do carbonato de sevelamer na remodelação óssea e na calcificação arterial em um modelo experimental de uremia com doença óssea adinâmica." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-09082013-131710/.

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INTRODUÇÃO: Há poucos modelos experimentais de doença óssea adinâmica (DOA) e os mecanismos fisiopatológicos dessa doença não são completamente compreendidos. Além disso, os efeitos dos quelantes de fósforo (P) na DOA têm sido pouco estudados. Este estudo objetivou estabelecer um modelo de DOA e avaliar os efeitos da terapia com carbonato de cálcio (Ca) e carbonato de sevelamer (sevelamer) sobre os distúrbios do metabolismo mineral e ósseo da doença renal crônica (DMO-DRC), no modelo estabelecido. MÉTODOS: Experimento 1: A DOA e a DRC foram induzidas por nefrectomia 5/6 (Nx) e paratireoidectom

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24

Salmon, Benjamin. "ASARM et biominéralisation de progéniteurs pulpaires." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T072.

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Dans le rachitisme hypophosphatémique lié à l’X (XLH), MEPE (Matrix Extracellular PhosphoglycoprotEin), une protéine non collagénique impliquée dans la biominéralisation, subit un clivage pathologique de son extrémité C-terminale. Les peptides ainsi libérés sont porteurs d’un domaine ASARM (acidic serine- and aspartate- rich motif) très conservé dans l’évolution. ASARM inhibe la réabsorption tubulaire du phosphate et la minéralisation de la matrice extracellulaire osseuse. Précédemment, notre équipe a identifié des taux élevés de ce peptide ASARM dérivé de MEPE dans la dentine issue de patient

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25

Schampel, Andrea. "Beneficial therapeutic effects of the L-type calcium channel antagonist nimodipine in experimental autoimmune encephalomyelitis – an animal model for multiple sclerosis." Doctoral thesis, 2017. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-148952.

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Multiple sclerosis (MS) is the most prevalent neurological disease of the central nervous system (CNS) in young adults and is characterized by inflammation, demyelination and axonal pathology that result in multiple neurological and cognitive deficits. The focus of MS research remains on modulating the immune response, but common therapeutic strategies are only effective in slowing down disease progression and attenuating the symptoms; they cannot cure the disease. Developing an option to prevent neurodegeneration early on would be a valuable addition to the current standard of care for MS. Ba

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26

WILSON, DAVID LYNN. "MODELING OF SINGLE CHANNEL AND WHOLE CELL CURRENT MEASUREMENTS WITH APPLICATION TO CALCIUM CHANNELS (NEURON, BIOPHYSICS, MARKOVIAN MODELS)." Thesis, 1985. http://hdl.handle.net/1911/15942.

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Modern measurements of membrane, ionic channel molecules consist of whole cell current relaxations obtained using various voltage pulse protocols, current noise power spectra from small numbers of channels, and single channel intervals in the form of waiting, closed, and open time histograms. A state-variable description was developed for predicting these measurements from Markovian state models, and it was used to analyze the parameter identifiability properties of the models and measurements. Computer programs were developed for estimating model parameters; these included maximum likelihood

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27

Brown, Chester M. "Influence of thyroid hormonal status on gene expression for calcium channels in the developing olfactory bulb and cerebellum of the postnatal rat /." 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3269849.

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Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007.<br>Source: Dissertation Abstracts International, Volume: 68-06, Section: B, page: 3581. Advisers: Esmail Meisami; Philip Best. Includes bibliographical references (leaves 98-117) Available on microfilm from Pro Quest Information and Learning.

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28

Wadel, Kristian. "The mechanism mediating fast neurotransmitter release at the calyx of Held synapse." Doctoral thesis, 2008. http://hdl.handle.net/11858/00-1735-0000-0006-B4F6-F.

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29

"Expression and localization of Alzheimer's disease (AD)-related proteins in senescence-accelerated mouse (SAM) and normal mouse." 2002. http://library.cuhk.edu.hk/record=b6073386.

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by Yao Hong-Bing.<br>"January 2002."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2002.<br>Includes bibliographical references (p. 113-135).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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30

Tétreault, Marie-Philippe. "Modifications post-traductionnelles des canaux calciques cardiaques de type L : identification des résidus asparagine qui participent à la glycosylation de la sous-unité auxiliaire CaVα2δ1". Thèse, 2015. http://hdl.handle.net/1866/13897.

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Les canaux calciques de type L CaV1.2 sont principalement responsables de l’entrée des ions calcium pendant la phase plateau du potentiel d’action des cardiomyocytes ventriculaires. Cet influx calcique est requis pour initier la contraction du muscle cardiaque. Le canal CaV1.2 est un complexe oligomérique qui est composé de la sous-unité principale CaVα1 et des sous-unités auxiliaires CaVβ et CaVα2δ1. CaVβ joue un rôle déterminant dans l’adressage membranaire de la sous-unité CaVα1. CaVα2δ1 stabilise l’état ouvert du canal mais le mécanisme moléculaire responsable de cette modulatio

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31

McKenney, Mikaela Lee. "Coronary artery disease progression and calcification in metabolic syndrome." Thesis, 2014. http://hdl.handle.net/1805/6460.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>For years, the leading killer of Americans has been coronary artery disease (CAD), which has a strong correlation to the U.S. obesity epidemic. Obesity, along with the presence of other risk factors including hyperglycemia, hypercholesterolemia, dyslipidemia, and high blood pressure, comprise of the diagnosis of metabolic syndrome (MetS). The presentation of multiple MetS risk factors increases a patients risk for adverse cardiovascular events. CAD is a complex progressive disease. We utilized the superb model of CAD and MetS, the Os

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32

Segura, Emilie. "Déterminants moléculaires du clivage protéolytique nécessaire à la fonction de la sous-unité CaVα2δ1 du canal calcique CaV1.2". Thèse, 2016. http://hdl.handle.net/1866/18902.

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Le canal calcique de type-L CaV1.2 participe au couplage excitation-contraction des cardiomyocytes. Cav1.2 est composé d’une sous-unité principale CaVα1, associée aux sous-unités auxiliaires CaVβ et CaVα2δ1. Lorsque présente à la membrane, c’est CaVα2δ1 qui est responsable de moduler la densité du courant calcique. Elle ne possède qu’un seul segment transmembranaire présent du côté C-terminal, au niveau de la protéine δ, ce qui en fait une protéine transmembranaire de type I. Certaines protéines qui appartiennent à cette famille doivent être clivées au niveau du site dit « omega », une modific

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33

Landry, Caroline. "Identification de nouvelles cibles thérapeutiques dans la dysfonction primaire du greffon suite à une transplantation pulmonaire." Thesis, 2020. http://hdl.handle.net/1866/25665.

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Introduction : La dysfonction primaire du greffon (DPG) post-transplantation pulmonaire est la principale cause de décès en phase péri-opératoire. Sa physiopathologie n’est pas encore totalement élucidée mais les lésions d’Ischémie/Reperfusion (I/R) pourraient constituer un facteur important de son développement. L’I/R et la DPG sont caractérisées par des dommages de l’endothélium vasculaire et de l’épithélium alvéolaire, un œdème pulmonaire et une réaction inflammatoire exacerbée. La résorption de l’œdème dépend du rétablissement de l’intégrité fonctionnelle alvéolaire, dont la capacité à réa

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