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Journal articles on the topic 'Calcium complex association'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Mirela, Mitu, Fița Ancuța, Balaci Teodora, Stănescu Andreea, and Crețu Emma. "BRAIN Journal - Study of the Formulation and Preparation of Chewable Tablets With a Calcium Complex Association and Vitamin D3." Brain Journal 1, https://www.edusoft.ro/brain/index.php/brain/article/view/116/237 (2010): 80–90. https://doi.org/10.5281/zenodo.1036720.

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ABSTRACT The experimental study objective was the development of chewable tablets with the calcium complex association, the minerals and vitamin D3 for children, subject to the rules as stipulated by the Romanian Pharmacopoeia Xth edition. Generating sources of calcium, used as raw materials in the preparation of these tablets are natural products represented by complex mineral rich in calcium - Lactoval°R HiCal (ratio of calcium and phosphorus is 2,2:1, report the same as breast milk) and 30% bovine colostrums [1, 3], making the absorption of calcium should be increased. Also, in order to fix

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Ibrahim, Salah M., and Ansam mahdi khaleel. "GINGIVAL HYPERPLASIA AND SYSTEMIC DISEASE: A COMPLEX INTERPLAY." Frontline Medical Sciences and Pharmaceutical Journal 04, no. 10 (2024): 23–37. http://dx.doi.org/10.37547/medical-fmspj-04-10-03.

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This study investigated the association between gingival hyperplasia and various systemic diseases and medications. Data from 1055 patients were analyzed, including those with leukemia, pregnancy, diabetes, and those taking medications known to induce gingival hyperplasia (phenytoin, cyclosporine, calcium channel blockers). Results indicated a significantly higher prevalence of gingival hyperplasia in patients with leukemia (40%, 95% CI: 30-50%) and poorly controlled diabetes (25%, 95% CI: 20-30%) compared to the control group (4%, 95% CI: 2-6%). Pregnancy also showed a statistically significa

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Karami, S., P. Brennan, M. Navratilova, et al. "Vitamin D Pathway Genes, Diet, and Risk of Renal Cell Carcinoma." International Journal of Endocrinology 2010 (2010): 1–11. http://dx.doi.org/10.1155/2010/879362.

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Mediated by binding to the high-affinity vitamin D receptor (VDR), vitamin D forms a heterodimer complex with the retinoid-X-receptor (RXR). Variation in both genes has been shown to modify renal cell carcinoma (RCC) risk. Therefore, we investigated whetherVDRandRXRApolymorphisms modify associations between RCC risk and frequency of dietary intake of vitamin D and calcium rich foods, and occupational ultraviolet exposure among 777 RCC case and 1035 controls from Central and Eastern Europe. A positive association was observed in this population between increasing dietary intake frequency of yog

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Chantler, P. D. "Calcium-dependent association of a protein complex with the lymphocyte plasma membrane: probable identity with calmodulin-calcineurin." Journal of Cell Biology 101, no. 1 (1985): 207–16. http://dx.doi.org/10.1083/jcb.101.1.207.

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A protein complex is shown to participate in a calcium-dependent association with plasma membranes purified either from pig mesenteric lymph node lymphocytes or from human lymphoblastoid cell lines. Plasma membranes prepared in the presence of calcium possess this complex; those prepared in the absence of calcium (5 mM EGTA) do not. The complex associates itself with the inner cytoplasmic surface of the plasma membrane. This complex is referred to as the "acidic protein band" because of its location during migration upon alkaline-urea gel electrophoresis. The complex dissociates from the plasm

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Chatterjee, Ranee, and Pao-Hwa Lin. "Serum calcium and its complex association with incident type 2 diabetes." American Journal of Clinical Nutrition 104, no. 4 (2016): 957–58. http://dx.doi.org/10.3945/ajcn.116.143321.

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Pereida-Jaramillo, Elizabeth, Gabriela B. Gómez-González, Angeles Edith Espino-Saldaña, and Ataúlfo Martínez-Torres. "Calcium Signaling in the Cerebellar Radial Glia and Its Association with Morphological Changes during Zebrafish Development." International Journal of Molecular Sciences 22, no. 24 (2021): 13509. http://dx.doi.org/10.3390/ijms222413509.

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Radial glial cells are a distinct non-neuronal cell type that, during development, span the entire width of the brain walls of the ventricular system. They play a central role in the origin and placement of neurons, since their processes form structural scaffolds that guide and facilitate neuronal migration. Furthermore, glutamatergic signaling in the radial glia of the adult cerebellum (i.e., Bergmann glia), is crucial for precise motor coordination. Radial glial cells exhibit spontaneous calcium activity and functional coupling spread calcium waves. However, the origin of calcium activity in

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Thelen, Kurt D., Evelyn P. Jackson, and Donald Penner. "The Basis for the Hard-Water Antagonism of Glyphosate Activity." Weed Science 43, no. 4 (1995): 541–48. http://dx.doi.org/10.1017/s0043174500081613.

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Hard-water cations, such as Ca+2and Mg+2, present in the spray solution can greatly reduce the efficacy of glyphosate. These cations potentially compete with the isopropylamine in the formulation for association with the glyphosate anion.14C-Glyphosate absorption by sunflower was reduced in the presence of Ca+2. The addition of ammonium sulfate overcame the observed decrease in14C-glyphosate absorption. Nuclear Magnetic Resonance (NMR) was used to study the chemical effects of calcium and calcium plus ammonium sulfate (AMS) on the glyphosate molecule. Data indicate an association of calcium wi

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Kapiloff, Michael S., Nicole Jackson, and Nathan Airhart. "mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope." Journal of Cell Science 114, no. 17 (2001): 3167–76. http://dx.doi.org/10.1242/jcs.114.17.3167.

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The physical association of regulatory enzymes and ion channels at relevant intracellular sites contributes to the diversity and specificity of second messenger-mediated signal transduction in cells. mAKAP is a scaffolding protein that targets the cAMP-dependent protein kinase A and phosphodiesterase type 4D3 to the nuclear envelope of differentiated cardiac myocytes. Here we present data that the mAKAP signaling complex also includes nuclear envelope-resident ryanodine receptors and protein phosphatase 2A. The ryanodine receptor is the major cardiac ion channel responsible for calcium-induced

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Nichols, C. Blake, Charles F. Rossow, Manuel F. Navedo, et al. "Sympathetic Stimulation of Adult Cardiomyocytes Requires Association of AKAP5 With a Subpopulation of L-Type Calcium Channels." Circulation Research 107, no. 6 (2010): 747–56. http://dx.doi.org/10.1161/circresaha.109.216127.

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Rationale: Sympathetic stimulation of the heart increases the force of contraction and rate of ventricular relaxation by triggering protein kinase (PK)A-dependent phosphorylation of proteins that regulate intracellular calcium. We hypothesized that scaffolding of cAMP signaling complexes by AKAP5 is required for efficient sympathetic stimulation of calcium transients. Objective: We examined the function of AKAP5 in the β-adrenergic signaling cascade. Methods and Results: We used calcium imaging and electrophysiology to examine the sympathetic response of cardiomyocytes isolated from wild type

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Lykken, Guinevere L., GuoZhou Chen, Evan D. Brutinel, Lingling Chen, and Timothy L. Yahr. "Characterization of ExsC and ExsD Self-Association and Heterocomplex Formation." Journal of Bacteriology 188, no. 19 (2006): 6832–40. http://dx.doi.org/10.1128/jb.00884-06.

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ABSTRACT Expression of the Pseudomonas aeruginosa type III secretion system (T3SS) is induced by calcium depletion and is positively regulated by the ExsA transcriptional activator and negatively regulated by the ExsD antiactivator. Under conditions permissive for expression of the T3SS, the negative regulatory activity of ExsD is antagonized by a direct binding interaction with ExsC. In the present study, the ExsC-ExsD binding interaction was characterized. Individually, both ExsC and ExsD form self-associated complexes, as judged by bacterial monohybrid and gel filtration experiments. A mixt

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Shao, Ying, Kirk J. Czymmek, Patricia A. Jones, et al. "Dynamic interactions between L-type voltage-sensitive calcium channel Cav1.2 subunits and ahnak in osteoblastic cells." American Journal of Physiology-Cell Physiology 296, no. 5 (2009): C1067—C1078. http://dx.doi.org/10.1152/ajpcell.00427.2008.

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Voltage-sensitive Ca2+ channels (VSCCs) mediate Ca2+ permeability in osteoblasts. Association between VSCC α1- and β-subunits targets channel complexes to the plasma membrane and modulates function. In mechanosensitive tissues, a 700-kDa ahnak protein anchors VSCCs to the actin cytoskeleton via the β2-subunit of the L-type Cav1.2 (α1C) VSCC complex. Cav1.2 is the major α1-subunit in osteoblasts, but the cytoskeletal complex and subunit composition are unknown. Among the four β-subtypes, the β2-subunit and, to a lesser extent, the β3-subunit coimmunoprecipitated with the Cav1.2 subunit in MC3T3

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Li, Danni, Jinming Li, and Yanfang Guo. "Genome-wide association study knowledge-driven pathway analysis of alcohol dependence implicates the calcium signaling pathway." Chinese Medical Journal 127, no. 12 (2014): 2229–35. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20132647.

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Background Alcohol dependence (AD) is a serious and common public health problem. The identification of genes that contribute to the AD variation will improve our understanding of the genetic mechanism underlying this complex disease. Previous genome-wide association studies (GWAS) and candidate gene genetic association studies identified individual genes as candidates for alcohol phenotypes, but efforts to generate an integrated view of accumulative genetic variants and pathways under alcohol drinking are lacking. Methods We applied enrichment gene set analysis to existing genetic association

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Labrador, Vénus, Kuang‐Den Chen, Yi‐Shuan Li, Sylvaine Muller, Jean‐François Stoltz, and Shu Chien. "Interactions of mechanotransduction pathways." Biorheology: The Official Journal of the International Society of Biorheology 40, no. 1-3 (2003): 47–52. http://dx.doi.org/10.1177/0006355x2003040001003008.

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Integrins may serve as mechanosensors in endothelial cells (ECs): shear stress causes integrin–Shc association, assembly of the signaling complex and then leads to JNK activation. Flow also mediates selective and cell‐specific alterations in vascular cell G‐protein expression that correlate with changes in cell‐signalling, G‐protein functionality and modulate Ca2+ concentration. In this study, we explored the cross‐talks between EC membrane mechanosensors, such as integrins, ion channels, and G‐proteins in shear stress‐induced signal transduction by their specific inhibition. Confluent monolay

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Dr., Suhas M. "Serum Calcium and Serum Magnesium Levels in Newly Detected Hypertensive Patients." International Journal of Medical and Pharmaceutical Research 5, no. 1 (2024): 30–35. https://doi.org/10.5281/zenodo.10517390.

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<strong>Background</strong>: Hypertension is a complex cardiovascular disorder with multifactorial etiology. This study aimed to investigate the association between serum calcium and magnesium levels and hypertension. <strong>Methods</strong>: A prospective observational study was conducted with 100 newly diagnosed hypertensive patients and 100 normotensive controls. Serum calcium and magnesium levels were measured, and their correlation with blood pressure was analyzed. <strong>Results</strong>: Hypertensive patients exhibited significantly higher serum calcium levels (9.8 ± 0.6 mg/dL)

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Peng, Qisheng, Shikha Malhotra, and Mary Beth Humphrey. "Association of TREM2-DAP12 with DAP10 is required for the regulation of PI3K in macrophages (98.18)." Journal of Immunology 184, no. 1_Supplement (2010): 98.18. http://dx.doi.org/10.4049/jimmunol.184.supp.98.18.

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Abstract The regulation of PI3K following TREM2 ligation in macrophages is unclear and was the focus of this study. Immunoprecipitation studies show that DAP10 signaling adapter protein is required for recruitment of PI3K (p85 subunit) to a TREM2-DAP12 complex following TREM2 ligation. Once recruited to the complex, PI3K mediates TREM2-DAP12 dependent activation of AKT and ERK1/2. Compared to wild type macrophages, TREM2 stimulation failed to induce p85 recruitment to DAP12 in DAP10-deficient macrophages leading to a significant reduction in activated AKT and ERK1/2. Calcium flux induced by TR

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Kypta, R. M., H. Su, and L. F. Reichardt. "Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex." Journal of Cell Biology 134, no. 6 (1996): 1519–29. http://dx.doi.org/10.1083/jcb.134.6.1519.

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Cadherins are calcium-dependent cell adhesion molecules that play fundamental roles in embryonic development, tissue morphogenesis, and cancer. A prerequisite for their function is association with the actin cytoskeleton via the catenins. Tyrosine phosphorylation of beta-catenin, which correlates with a reduction in cadherin-dependent cell adhesion, may provide cells with a mechanism to regulate cadherin activity. Here we report that beta-catenin immune precipitates from PC12 cells contain tyrosine phosphatase activity which dephosphorylates beta-catenin in vitro. In addition, we show that a m

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Debowska, Malgorzata, Lu Dai, Alicja Wojcik-Zaluska, et al. "Association between Biomarkers of Mineral and Bone Metabolism and Removal of Calcium and Phosphate in Hemodialysis." Blood Purification 49, no. 1-2 (2019): 71–78. http://dx.doi.org/10.1159/000503623.

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Background: A significant drop of serum phosphate and calcium removal or loading during hemodialysis induce reactions in mineral and bone remodeling that may inversely affect phosphate and calcium removal during dialysis. Objectives: We aimed to analyze the interdependencies between biomarkers of mineral and bone metabolism and removal of phosphate and calcium during hemodialysis, as this complex relationship is not fully understood. Methods: Three subsequent hemodialysis sessions during a 1-week treatment cycle with interdialytic periods of 2–2-3 days were monitored in 25 anuric patients. Cal

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Avery, Jade, Tennille Leak-Johnson, and Sharon C. Francis. "Association between MCU Gene Polymorphisms with Obesity: Findings from the All of Us Research Program." Genes 15, no. 4 (2024): 512. http://dx.doi.org/10.3390/genes15040512.

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Obesity is a public health crisis, and its prevalence disproportionately affects African Americans in the United States. Dysregulation of organelle calcium homeostasis is associated with obesity. The mitochondrial calcium uniporter (MCU) complex is primarily responsible for mitochondrial calcium homeostasis. Obesity is a multifactorial disease in which genetic underpinnings such as single-nucleotide polymorphisms (SNPs) may contribute to disease progression. The objective of this study was to identify genetic variations of MCU with anthropometric measurements and obesity in the All of Us Resea

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Emond, Michelle R., Sayantanee Biswas, Cheasequah J. Blevins, and James D. Jontes. "A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion." Journal of Cell Biology 195, no. 7 (2011): 1115–21. http://dx.doi.org/10.1083/jcb.201108115.

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During embryonic morphogenesis, adhesion molecules are required for selective cell–cell interactions. The classical cadherins mediate homophilic calcium-dependent cell adhesion and are founding members of the large and diverse cadherin superfamily. The protocadherins are the largest subgroup within this superfamily, yet their participation in calcium-dependent cell adhesion is uncertain. In this paper, we demonstrate a novel mechanism of adhesion, mediated by a complex of Protocadherin-19 (Pcdh19) and N-cadherin (Ncad). Although Pcdh19 alone is only weakly adhesive, the Pcdh19–Ncad complex exh

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Chao, Jun-Tzu, Peichun Gui, Gerald W. Zamponi, George E. Davis та Michael J. Davis. "Spatial association of the Cav1.2 calcium channel with α5β1-integrin". American Journal of Physiology-Cell Physiology 300, № 3 (2011): C477—C489. http://dx.doi.org/10.1152/ajpcell.00171.2010.

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Engagement of α5β1-integrin by fibronectin (FN) acutely enhances Cav1.2 channel (CaL) current in rat arteriolar smooth muscle and human embryonic kidney cells (HEK293-T) expressing CaL. Using coimmunoprecipitation strategies, we show that coassociation of CaL with α5- or β1-integrin in HEK293-T cells is specific and depends on cell adhesion to FN. In rat arteriolar smooth muscle, coassociations between CaL and α5β1-integrin and between CaL and phosphorylated c-Src are also revealed and enhanced by FN treatment. Using site-directed mutagenesis of CaL heterologously expressed in HEK293-T cells,

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Findeisen, Felix, and Daniel L. Minor. "Disruption of the IS6-AID Linker Affects Voltage-gated Calcium Channel Inactivation and Facilitation." Journal of General Physiology 133, no. 3 (2009): 327–43. http://dx.doi.org/10.1085/jgp.200810143.

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Two processes dominate voltage-gated calcium channel (CaV) inactivation: voltage-dependent inactivation (VDI) and calcium-dependent inactivation (CDI). The CaVβ/CaVα1-I-II loop and Ca2+/calmodulin (CaM)/CaVα1–C-terminal tail complexes have been shown to modulate each, respectively. Nevertheless, how each complex couples to the pore and whether each affects inactivation independently have remained unresolved. Here, we demonstrate that the IS6–α-interaction domain (AID) linker provides a rigid connection between the pore and CaVβ/I-II loop complex by showing that IS6-AID linker polyglycine mutat

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Chitaev, Nikolai A., and Sergey M. Troyanovsky. "Adhesive But Not Lateral E-cadherin Complexes Require Calcium and Catenins for Their Formation." Journal of Cell Biology 142, no. 3 (1998): 837–46. http://dx.doi.org/10.1083/jcb.142.3.837.

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We examined intercadherin interactions in epithelial A-431 cells producing endogenous E-cadherin and recombinant forms of E-cadherin tagged either by myc or by flag epitopes. Three distinct E-cadherin complexes were found. The first is a conventional E-cadherin–catenin complex consisting of one E-cadherin molecule linked either to β-catenin/α-catenin or to plakoglobin/α-catenin dimers. The second is a lateral E-cadherin complex incorporating two E-cadherin– catenin conventional complexes combined in parallel fashion via dimerization of the NH2-terminal extracellular domain of E-cadherin. The t

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da Silva, Maria Canellas, and Sarah Kuzmiak-Glancy. "Phosphate Regulates the Acute Changes in Complex V Association in Skeletal Muscle Mitochondria During Calcium Overload." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1865 (September 2024): 149250. http://dx.doi.org/10.1016/j.bbabio.2024.149250.

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Castro, Ricardo I., Luis Morales-Quintana, Nancy Alvarado, et al. "Design and Optimization of a Self-Assembling Complex Based on Microencapsulated Calcium Alginate and Glutathione (CAG) Using Response Surface Methodology." Polymers 13, no. 13 (2021): 2080. http://dx.doi.org/10.3390/polym13132080.

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The aim of this work was to characterize and optimize the formation of molecular complexes produced by the association of calcium alginate and reduced glutathione (GSH). The influence of varying concentrations of calcium and GSH on the production of microcapsules was analyzed using response surface methodology (RSM). The microcapsules were characterized by thermogravimetric analysis (TGA-DTG) and infrared spectroscopy (FTIR) in order to assess the hydration of the complexes, their thermal stability, and the presence of GSH within the complexes. The optimum conditions proposed by RSM to reach t

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Rajasekaran, A. K., M. Hojo, T. Huima, and E. Rodriguez-Boulan. "Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions." Journal of Cell Biology 132, no. 3 (1996): 451–63. http://dx.doi.org/10.1083/jcb.132.3.451.

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We characterized the role of the E-cadherin adhesion system in the formation of epithelial tight junctions using the calcium switch model. In MDCK cells cultured in low (micromolar) calcium levels, the tight junctional protein Zonula Occludens-1 (ZO-1) is distributed intracellularly in granular clusters, the larger of which codistribute with E-cadherin. Two hours after activation of E-cadherin adhesion by transfer to normal (1.8 mM) calcium levels, ZO-1 dramatically redistributed to the cell surface, where it localized in regions rich in E-cadherin. Immunoprecipitation with ZO-1 antibodies of

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Jahan, Ishrat, Hazera Akter, Md Azizul Hossain, Rezoana Najnin, Md Ashraful Islam, and Kazi Abdul Mannan. "Association between Serum Calcium Level and Hypoxic-Ischemic Encephalopathy (HIE) Stages in Term Neonate with Perinatal Asphyxia." Journal of Comilla Medical College Teachers' Association 28, no. 2 (2024): 87–91. https://doi.org/10.3329/jcomcta.v28i2.78019.

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Background: Perinatal asphyxia (PNA) is a devastating clinical condition because it causes permanent brain damage, even death of the newborn. Perinatal asphyxia is a common neonatal problem in our context. There is a need to identify neonates with PNA who will be at high risk for hypoxic ischemic encephalopathy and multi-organ dysfunction. Objective: To evaluate the association between serum calcium level and hypoxic-ischemic encephalopathy (HIE) stages in term neonate with perinatal asphyxia. Methods: A cross-sectional study was conducted in the Department of Paediatrics, Comilla Medical Coll

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Mische, S. M., M. S. Mooseker, and J. S. Morrow. "Erythrocyte adducin: a calmodulin-regulated actin-bundling protein that stimulates spectrin-actin binding." Journal of Cell Biology 105, no. 6 (1987): 2837–45. http://dx.doi.org/10.1083/jcb.105.6.2837.

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Adducin is an erythrocyte membrane skeletal phosphoprotein comprised of two related subunits of 105,000 and 100,000 Mr. These peptides form a functional heterodimer, and the smaller of the two binds calmodulin in a calcium-dependent fashion. Although this protein has been physicochemically characterized, its function remains unknown. We have examined the interaction of human adducin with actin and with human erythrocyte spectrin using sedimentation, electrophoretic, and morphologic techniques. Purified adducin binds actin at physiologic ionic strength and bundles it into arrays of laterally ar

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Campiglio, Marta, Pierre Costé de Bagneaux, Nadine J. Ortner, Petronel Tuluc, Filip Van Petegem, and Bernhard E. Flucher. "STAC proteins associate to the IQ domain of CaV1.2 and inhibit calcium-dependent inactivation." Proceedings of the National Academy of Sciences 115, no. 6 (2018): 1376–81. http://dx.doi.org/10.1073/pnas.1715997115.

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The adaptor proteins STAC1, STAC2, and STAC3 represent a newly identified family of regulators of voltage-gated calcium channel (CaV) trafficking and function. The skeletal muscle isoform STAC3 is essential for excitation–contraction coupling and its mutation causes severe muscle disease. Recently, two distinct molecular domains in STAC3 were identified, necessary for its functional interaction with CaV1.1: the C1 domain, which recruits STAC proteins to the calcium channel complex in skeletal muscle triads, and the SH3-1 domain, involved in excitation–contraction coupling. These interaction si

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Deaglio, Silvia, Tiziana Vaisitti, Richard Billington, et al. "CD38/CD19: a lipid raft–dependent signaling complex in human B cells." Blood 109, no. 12 (2007): 5390–98. http://dx.doi.org/10.1182/blood-2006-12-061812.

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Abstract The present work deals with the mechanisms of signal transduction mediated via CD38 in normal and neoplastic human B lymphocytes. The results indicate that CD38 is a receptor and that CD38-mediated signals are tightly regulated at 3 distinct levels. The first concerns the structural organization of CD38, which is clearly divided into monomeric and dimeric forms. The second level of regulation is based on the dynamic localization of CD38 molecules in lipid microdomains within the plasma membrane. Lateral associations with other proteins, namely with the CD19/CD81 complex, determine the

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Liu, Li, Olle Harbecke, Hans Elwing, Per Follin, Anna Karlsson, and Claes Dahlgren. "Desensitization of Formyl Peptide Receptors Is Abolished in Calcium Ionophore-Primed Neutrophils: An Association of the Ligand-Receptor Complex to the Cytoskeleton Is Not Required for a Rapid Termination of the NADPH-Oxidase Response." Journal of Immunology 160, no. 5 (1998): 2463–68. http://dx.doi.org/10.4049/jimmunol.160.5.2463.

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Abstract Binding of ligands to N-formyl peptide chemoattractant receptors exposed on human neutrophils generates signals in the cells that induce an activation of the superoxide anion producing NADPH-oxidase. Ligand binding is followed by a rapid association of the ligand-receptor complex with the cytoskeleton, a process leading to desensitization of the cells with respect to NADPH-oxidase activation. We show that neutrophils that have experienced an intracellular calcium rise obtained through interaction with the calcium-specific ionophore ionomycin are “primed” with respect to the FMLP-induc

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Apicco, Daniel J., Evgeny Shlevkov, Catherine L. Nezich та ін. "The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release". Proceedings of the National Academy of Sciences 118, № 1 (2020): e2006476118. http://dx.doi.org/10.1073/pnas.2006476118.

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Inositol-1,4,5-triphosphate (IP3) kinase B (ITPKB) is a ubiquitously expressed lipid kinase that inactivates IP3, a secondary messenger that stimulates calcium release from the endoplasmic reticulum (ER). Genome-wide association studies have identified common variants in the ITPKB gene locus associated with reduced risk of sporadic Parkinson’s disease (PD). Here, we investigate whether ITPKB activity or expression level impacts PD phenotypes in cellular and animal models. In primary neurons, knockdown or pharmacological inhibition of ITPKB increased levels of phosphorylated, insoluble α-synucl

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Voorhies, Kirsten, Kendra Young, Fang-Chi Hsu, et al. "Association of PHACTR1 with Coronary Artery Calcium Differs by Sex and Cigarette Smoking." Journal of Cardiovascular Development and Disease 11, no. 7 (2024): 194. http://dx.doi.org/10.3390/jcdd11070194.

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Background: Coronary artery calcium (CAC) is a marker of subclinical atherosclerosis and is a complex heritable trait with both genetic and environmental risk factors, including sex and smoking. Methods: We performed genome-wide association (GWA) analyses for CAC among all participants and stratified by sex in the COPDGene study (n = 6144 participants of European ancestry and n = 2589 participants of African ancestry) with replication in the Diabetes Heart Study (DHS). We adjusted for age, sex, current smoking status, BMI, diabetes, self-reported high blood pressure, self-reported high cholest

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Askari, Masoumeh, Arefeh Abbaszadeh, Mansoore Saharkhiz, et al. "A study of the association between cognitive abilities and dietary intake in young women." Nutrition and Health 26, no. 3 (2020): 263–70. http://dx.doi.org/10.1177/0260106020940116.

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Background: Cognitive abilities comprise activities that relate to receiving and responding to information from the environment, internal processing, making complex decisions, and then responding to this in the context of behavior. Aim: The current study investigated the association between dietary intake and seven aspects of cognitive abilities among healthy young women. Methods: The study was carried out among 182 women aged 18–25 years. A valid and reliable food frequency questionnaire containing 65 food items was used to estimate dietary intake. Neuropsychological function and cognitive ab

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Cipolletta, E., S. Monaco, A. S. Maione, et al. "Calmodulin-Dependent Kinase II Mediates Vascular Smooth Muscle Cell Proliferation and Is Potentiated by Extracellular Signal Regulated Kinase." Endocrinology 151, no. 6 (2010): 2747–59. http://dx.doi.org/10.1210/en.2009-1248.

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Vascular smooth muscle cell (VSMC) proliferation contributes to vascular remodeling in atherosclerosis and hypertension. Calcium-dependent signaling through calcium/calmodulin-dependent kinase II (CaMKII) and ERK1/2 activation plays an important role in the regulation of VSMC proliferation by agents such as α-adrenergic receptor agonists. Nevertheless, how the CaMKII and ERK pathways interact in VSMCs has yet to be characterized. The aim of the present study was to clarify this interaction in response to α1-adrenergic receptor-mediated VSMC proliferation. We discovered that phenylephrine stimu

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Ramanagoudr-Bhojappa, Ramanagouda, Yong Miao та Monika Vig. "High affinity associations with α-SNAP enable calcium entry via Orai1 channels". PLOS ONE 16, № 10 (2021): e0258670. http://dx.doi.org/10.1371/journal.pone.0258670.

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Molecular steps that activate store-operated calcium entry (SOCE) via Orai channel supramolecular complex remain incompletely defined. We have earlier shown that α-SNAP regulates the on-site functional assembly and calcium selectivity of Orai1 channels. Here we investigate the molecular basis of its association with Orai, Stim and find that the affinity of α-SNAP for Orai and Stim is substantially higher than previously reported affinities between Stim and Orai sub-domains. α-SNAP binds the coiled-coil 3 (CC3) sub-domain of Stim1. Mutations of Tryptophan 430 in Stim1-CC3 disrupted α-SNAP assoc

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Ivasenko, Ruslan N., Yuri V. Popov, Marina I. Fomina, Tatiyana I. Mikhalitsyna, and Elena D. Skilskaya. "Mineral Associations of Gold-Ore Occurences, Berental Ore Cluster (North-East of Russia)." UNIVERSITY NEWS. NORTH-CAUCASIAN REGION. NATURAL SCIENCES SERIES, no. 1 (205) (March 31, 2020): 53–61. http://dx.doi.org/10.18522/1026-2237-2020-1-53-61.

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Berental prospective ore cluster (Magadan region) hosts a many ore occurrences, which differ in mineral composition, ore productivity, features of secondary and primary dispersion halos. As a result of the study of ores, mineral associations have been characterized, the stages of formation of ore occurrences and the alteration of the ore cluster have been established. The interrelation of five genetic types of native gold with mineral associations is revealed. Key ore occurrences have formed during several stages of ore formation associated with the evolution of a common hydro-thermal system.

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Béguin, Pascal, Kazuaki Nagashima, Ramasubbu N. Mahalakshmi, et al. "BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis." Journal of Cell Biology 205, no. 2 (2014): 233–49. http://dx.doi.org/10.1083/jcb.201304101.

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Voltage-gated calcium channels (VGCCs) are key regulators of cell signaling and Ca2+-dependent release of neurotransmitters and hormones. Understanding the mechanisms that inactivate VGCCs to prevent intracellular Ca2+ overload and govern their specific subcellular localization is of critical importance. We report the identification and functional characterization of VGCC β-anchoring and -regulatory protein (BARP), a previously uncharacterized integral membrane glycoprotein expressed in neuroendocrine cells and neurons. BARP interacts via two cytosolic domains (I and II) with all Cavβ subunit

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Xie, Guofeng, and Jean-Pierre Raufman. "Association of protein kinase A with AKAP150 facilitates pepsinogen secretion from gastric chief cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 281, no. 4 (2001): G1051—G1058. http://dx.doi.org/10.1152/ajpgi.2001.281.4.g1051.

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Cross talk between signal transduction pathways augments pepsinogen secretion from gastric chief cells. A-kinase anchoring proteins (AKAPs) associate with regulatory subunits of protein kinase A (PKA), protein kinase C (PKC), and protein phosphatase 2B (PP2B) and localize this protein complex to specific cell compartments. We determined whether an AKAP-signaling protein complex exists in chief cells and whether this modulates secretion. In Western blots, we identified AKAP150, a rodent homologue of human AKAP79 that coimmunoprecipitates with PKA, PKC, and actin. The association of PKA and PP2B

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Andrino, Sandra, Valentina Lorenzo, Susana Dunner, Elisabeth Contreras, Javier Cañón, and Natalia Sevane. "Syringohydromyelia in Dogs: The Genomic Component Underlying a Complex Neurological Disease." Animals 12, no. 19 (2022): 2622. http://dx.doi.org/10.3390/ani12192622.

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Syringohydromyelia (SHM) is a neurological disorder characterized by the appearance of fluid-containing cavities within the spinal cord. Although SHM is thought to be under multigenic control, the molecular basis of this disease remains poorly defined. A genome-wide association study (GWAS) was carried out comparing the whole genome sequences (WGS) from 12 dogs with SHM and 2 panels of 26 dogs (either older than 5 years and showing the absence of SHM or belonging to breeds not susceptible to SHM) to identify candidate genes associated with the development of SHM. Seven candidate genes were ide

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García, Jesús. "The calcium channel α2/δ1 subunit interacts with ATP5b in the plasma membrane of developing muscle cells". American Journal of Physiology-Cell Physiology 301, № 1 (2011): C44—C52. http://dx.doi.org/10.1152/ajpcell.00405.2010.

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The α2/δ1 and α11.1 subunits are present at a 1:1 ratio in the dihydropyridine receptor (DHPR) from adult skeletal muscle. In contrast, during early myotube development α2/δ1 is present at higher levels than α11.1 and localizes at the ends of the cells, suggesting that α2/δ1 may have a role independent from DHPRs. We sought to identify binding partners of α2/δ1 at a period when levels of α11.1 are low. Analysis of protein complexes in their native configuration established that α2/δ1 may be associating with ATP5b, a subunit of a mitochondrial ATP synthase complex. This interaction was confirme

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Vervloet, Marc G. "Shedding Light on the Complex Regulation of FGF23." Metabolites 12, no. 5 (2022): 401. http://dx.doi.org/10.3390/metabo12050401.

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Early research has suggested a rather straightforward relation between phosphate exposure, increased serum FGF23 (Fibroblast Growth Factor 23) concentrations and clinical endpoints. Unsurprisingly, however, subsequent studies have revealed a much more complex interplay between autocrine and paracrine factors locally in bone like PHEX and DMP1, concentrations of minerals in particular calcium and phosphate, calciprotein particles, and endocrine systems like parathyroid hormone PTH and the vitamin D system. In addition to these physiological regulators, an expanding list of disease states are sh

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Pateel, Deepak Gowda Sadashivappa, Shilpa Gunjal, Liew Fong Fong, and Nur Sulwana Mohd Hanapi. "Association of Salivary Statherin, Calcium, and Proline-Rich Proteins on Oral Hygiene: A Cross-Sectional Study." International Journal of Dentistry 2021 (February 23, 2021): 1–6. http://dx.doi.org/10.1155/2021/1982083.

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Background. Saliva, as a complex biofluid, plays a pivotal role in maintaining oral health and tooth integrity. There has been inconsistent data available on the relationship between salivary parameters and oral health. This study aims to investigate the association between salivary statherin, acidic proline-rich proteins (aPRP), and calcium with oral hygiene status. Methods. One hundred and eighty-eight healthy subjects aged between 18 and 50 years with varying oral hygiene status who gave consent to participate were included in this cross-sectional study. The subjects were recruited from pri

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Meng, Haoliang, Yan He, Yukun Rui, et al. "Genetic Predisposition and Mitochondrial Dysfunction in Sudden Cardiac Death: Role of MCU Complex Genetic Variations." Cells 14, no. 10 (2025): 728. https://doi.org/10.3390/cells14100728.

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Sudden cardiac death (SCD) is a major cause of cardiovascular mortality, with coronary artery disease-related SCD (SCD-CAD) being the most prevalent form. Genetic factors and mitochondrial dysfunction, particularly in calcium homeostasis, are critical in SCD-CAD. However, the specific genetic factors linked to mitochondrial dysfunction in SCD-CAD remain poorly understood. In this case-control study, we analyzed 229 SCD-CAD cases and 598 controls from a Southern Han Chinese population, focusing on 12 insertion-deletion (indel) variants across six mitochondrial calcium uniporter (MCU) complex ge

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Josse, S., C. Faucheux, A. Soueidan, et al. "A Novel Drug Delivery System for Bisphosphonates: Innovative Strategy for Local Treatment of Bone Resorption." Key Engineering Materials 284-286 (April 2005): 399–402. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.399.

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One type of potent aminobisphosphonate (Zoledronate) has been chemically associated onto b-tricalcium phosphate [b-TCP] and calcium deficients apatite [CDA]. Two different association modes have been observed, according to the nature of the Calcium Phosphate [CaP] support and/or the initial concentration of the Zoledronate solution. b-TCP appears to promote Zoledronate-containing crystals formation. On the other hand, at concentrations < 0.05 mol.L-1 CDA seems to undergo chemisorption of the drug through a surface adsorption process, due to PO3 for PO4 exchange, which is well described by F

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Beáta, Jakó, Benedek Theodora, Suciu Zsuzsanna, and Benedek I. "Correlations Between Regional Accumulation of Calcium in the Culprit Arteries and Plaque Burden in Acute Coronary Syndromes." Acta Medica Marisiensis 59, no. 5 (2013): 270–73. http://dx.doi.org/10.2478/amma-2013-0063.

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Abstract Introduction: The association between a high calcium score at the level of the unstable coronary lesions and the different characteristic of culprit lesions which result in an acute coronary syndrome (ACS) has not been described yet. We aimed to study the correlation between the accumulation of calcium within the vessel wall of a coronary artery and the plaque burden of culprit lesions that develop an acute coronary event. Material and methods: A total of 45 patients with ACS (22 unstable angina, 23 nonST elevation myocardial infarction) underwent 64-slice CCTA. In all patients a comp

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Smith, Andrew L., Michael R. Dohn, Meredith V. Brown, and Albert B. Reynolds. "Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin." Molecular Biology of the Cell 23, no. 1 (2012): 99–110. http://dx.doi.org/10.1091/mbc.e11-06-0497.

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The dynamic functional linkage of cadherins with the underlying actin cytoskeleton is tightly regulated to achieve proper cell–cell adhesion. p120-catenin (p120) regulates both cadherin stability and actin dynamics, but the relationship between these two functions remains unclear. Using a novel proteomic approach called reversible cross-link immunoprecipitation, or ReCLIP, we previously identified a physical interaction between p120 and Rho-associated protein kinase 1 (ROCK1), a major effector of RhoA. In this paper, we show that a discrete fraction of cellular ROCK1 coimmunoprecipitates with

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Petrovic, Mira, and Marija Kastelan-Macan. "The uptake of inorganic phosphorus by insoluble metal-humic complexes." Water Science and Technology 34, no. 7-8 (1996): 253–58. http://dx.doi.org/10.2166/wst.1996.0629.

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Interaction and binding of dissolved orthophosphate on insoluble complexes of marine humic substances and calcium, magnesium, iron and aluminium have been studied. The results pointed out that solubility of metal-humic and fulvic complexes increases as the pH of the suspension increases with strong phosphorus fixation at pH-values between 4 and 6. The possible mechanism of this binding involves formation of a complex association in which metal ions bound to the humic substances act as a bridge between humic macromolecules and phosphate anion.

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Coluccio, LM, and A. Bretscher. "Mapping of the microvillar 110K-calmodulin complex: calmodulin-associated or -free fragments of the 110-kD polypeptide bind F-actin and retain ATPase activity." Journal of Cell Biology 106, no. 2 (1988): 367–73. http://dx.doi.org/10.1083/jcb.106.2.367.

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The 110K-calmodulin complex isolated from intestinal microvilli is an ATPase consisting of one polypeptide chain of 110 kD in association with three to four calmodulin molecules. This complex is presumably the link between the actin filaments in the microvillar core and the surrounding cell membrane. To study its structural regions, we have partially cleaved the 110K-calmodulin complex with alpha-chymotrypsin; calmodulin remains essentially intact under the conditions used. As determined by 125I-calmodulin overlays, ion exchange chromatography, and actin-binding assays, a 90-kD digest fragment

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Fu, Yingli, Na Zhou, Wei Bai, et al. "Association of the CACNA2D2 gene with schizophrenia in Chinese Han population." PeerJ 8 (February 5, 2020): e8521. http://dx.doi.org/10.7717/peerj.8521.

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Background Schizophrenia (SCZ) is a severely complex psychiatric disorder in which ~80% can be explained by genetic factors. Single nucleotide polymorphisms (SNPs) in calcium channel genes are potential genetic risk factors for a spectrum of psychiatric disorders including SCZ. This study evaluated the association between SNPs in the voltage-gated calcium channel auxiliary subunit alpha2delta 2 gene (CACNA2D2) and SCZ in the Han Chinese population of Northeast China. Methods A total of 761 SCZ patients and 775 healthy controls were involved in this case-control study. Three SNPs (rs3806706, rs

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Ullah, Khalil, Sajid Ur Rehman, Ramsha Nadeem, Muhammad Abubakar, and Qasim Raza. "Association of Vitamin D Deficiency in Newly Diagnosed Pulmonary Tuberculosis." Pakistan Journal of Medical and Health Sciences 15, no. 10 (2021): 2572–73. http://dx.doi.org/10.53350/pjmhs2115102572.

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Aim: Relationship between Vitamin D deficiency and pulmonary tuberculosis. Methodology: Study duration: November 2020 to April 2021 Sampling technique: A case-control study Setting: Hayatabad Medical Complex, Peshawar It included 30 adult newly identified sputum-quality pulmonary tuberculosis patients and 30 age and sex matched healthy cases as controls. All cases had undergone a thorough medical examination and repeated laboratory tests, including vitamin D, calcium, and sputum for AFB and X-ray chest. Results: Majority were males (88%). In the Study group, BMI decreased significantly i.e. 19

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