Academic literature on the topic 'Calcium phosphate cement, biocompatibility, mesenchymal stem cell, bone regeneration'

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Journal articles on the topic "Calcium phosphate cement, biocompatibility, mesenchymal stem cell, bone regeneration"

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Thinh, Nguyen Tien. "ENZYMATIC PREPARATION OF MODULATED–BIODEGRADABLE HYDROGEL NANOCOMPOSITES BASED CHITOSAN/GELATIN AND BIPHASIC CALCIUM PHOSPHATE NANOPARTICLES." Vietnam Journal of Science and Technology 55, no. 1B (2018): 185. http://dx.doi.org/10.15625/2525-2518/55/1b/12107.

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In the study, injectable chitosan–4 hydroxyphenylacectamide acid (CHPA) and gelatin–tyramine (GTA)–based hydrogels were enzymatically prepared, in which could encapsulate biphasic calcium phosphate nanoparticles (BCP NPs) for enhancing bone regeneration. The in situ formation of hydrogel composite was varied from 35 to 80 seconds depending on concentration of H2O2. Collagenase–mediated biodegradation of the hydrogel composite could be modulated from 3 days to over one month depending on amount of the formulated CHPA. Live/dead cell viability assay indicated that the hydrogel composite enhanced
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Gandolfi, Maria Giovanna, Chiara Gardin, Fausto Zamparini, et al. "Mineral-Doped Poly(L-lactide) Acid Scaffolds Enriched with Exosomes Improve Osteogenic Commitment of Human Adipose-Derived Mesenchymal Stem Cells." Nanomaterials 10, no. 3 (2020): 432. http://dx.doi.org/10.3390/nano10030432.

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Exosomes derived from mesenchymal stem cells are extracellular vesicles released to facilitate cell communication and function. Recently, polylactic acid (PLA), calcium silicates (CaSi), and dicalcium phosphate dihydrate (DCPD) have been used to produce bioresorbable functional mineral-doped porous scaffolds-through thermally induced phase separation technique, as materials for bone regeneration. The aim of this study was to investigate the effect of mineral-doped PLA-based porous scaffolds enriched with exosome vesicles (EVs) on osteogenic commitment of human adipose mesenchymal stem cells (h
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Lesci, Isidoro Giorgio, Leonardo Ciocca, Odila Mezini, and Norberto Roveri. "Synthetic Biomimetic HA Composite Scaffolds for the Bone Regenerative Medicine Using CAD-CAM Technology." Key Engineering Materials 672 (January 2016): 235–46. http://dx.doi.org/10.4028/www.scientific.net/kem.672.235.

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The study of nanocrystalline calcium phosphate physical-chemical characteristics and, thereafter, the possibility to imitate bone mineral for the development of new advanced biomaterials is constantly growing. The availability to use synthetic biomimetic hydroxylapatites (HA), since they are the most important inorganic constituents of hard tissues in vertebrates, represents a great turning point in bone tissue engineering because of their chemical similarity to the biological mineral component. The ability to control the architecture and strength of a bone tissue engineering scaffold is criti
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Gunnella, Francesca, Elke Kunisch, Victoria Horbert, et al. "In Vitro Release of Bioactive Bone Morphogenetic Proteins (GDF5, BB-1, and BMP-2) from a PLGA Fiber-Reinforced, Brushite-Forming Calcium Phosphate Cement." Pharmaceutics 11, no. 9 (2019): 455. http://dx.doi.org/10.3390/pharmaceutics11090455.

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Bone regeneration of sheep lumbar osteopenia is promoted by targeted delivery of bone morphogenetic proteins (BMPs) via a biodegradable, brushite-forming calcium-phosphate-cement (CPC) with stabilizing poly(l-lactide-co-glycolide) acid (PLGA) fibers. The present study sought to quantify the release and bioactivity of BMPs from a specific own CPC formulation successfully used in previous in vivo studies. CPC solid bodies with PLGA fibers (0%, 5%, 10%) containing increasing dosages of GDF5, BB-1, and BMP-2 (2 to 1000 µg/mL) were ground and extracted in phosphate-buffered saline (PBS) or pure she
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Hu, Longwei, Yang Wang, Hongya Pan, et al. "Apoptosis repressor with caspase recruitment domain (ARC) promotes bone regeneration of bone marrow-derived mesenchymal stem cells by activating Fgf-2/PI3K/Akt signaling." Stem Cell Research & Therapy 12, no. 1 (2021). http://dx.doi.org/10.1186/s13287-021-02253-5.

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Abstract Objectives This study aims to investigate whether apoptosis repressor with caspase recruitment domain (ARC) could promote survival and enhance osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). Materials and methods The lentivirus transfection method was used to establish ARC-overexpressing BMSCs. The CCK-8 method was used to detect cell proliferation. The BD Pharmingen™ APC Annexin V Apoptosis Detection kit was used to detect cell apoptosis. The osteogenic capacity was investigated by OCN immunofluorescence staining, ALP analysis, ARS assays, and RT-PCR
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Chen, Mingjiao, Meng Zhou, Yao Fu, Jin Li, and Zi Wang. "Effects of miR-672 on the angiogenesis of adipose-derived mesenchymal stem cells during bone regeneration." Stem Cell Research & Therapy 12, no. 1 (2021). http://dx.doi.org/10.1186/s13287-021-02154-7.

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Abstract Background Sufficient vascular network plays an important role in the repair of bone defects. Bone morphogenetic protein 2 (BMP2) being a key regulator of angiogenesis has attracted the attention of researchers. In addition, evidence has suggested that BMP2 coordinates with microRNAs (miRNAs) to form intracellular networks regulating mesenchymal stem cells (MSCs) angiogenesis. Elucidating the underlying mechanisms that are regulating adipose-derived mesenchymal stem cells (ADSCs) angiogenesis might provide more effective method to enhance bone regeneration. Methods We identified the s
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Dissertations / Theses on the topic "Calcium phosphate cement, biocompatibility, mesenchymal stem cell, bone regeneration"

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Vater, Corina. "Biologische Charakterisierung neuartiger nanokristalliner Calciumphosphatzemente für die Knochenregeneration." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-37761.

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Ziel der vorliegenden Arbeit war die biologische Charakterisierung neuartiger nanostrukturierter und für die Knochenregeneration geeigneter Calciumphosphatzemente (CPC). Hierzu wurde ein aus α-Tricalciumphosphat, Calciumhydrogenphosphat, gefälltem Hydroxylapatit und Calciumcarbonat bestehender CPC verwendet, der mit den Biomolekülen Cocarboxylase, Glucuronsäure, Weinsäure, Glucose-1-phosphat, Arginin, Lysin und Asparaginsäure-Natriumsalz modifiziert wurde. Ermittelt wurde dabei der Einfluss der Modifikationen auf die Proteinadsorption und die Biokompatibilität. In Vorversuchen wurden die Zemen
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Vater, Corina. "Biologische Charakterisierung neuartiger nanokristalliner Calciumphosphatzemente für die Knochenregeneration." Doctoral thesis, 2009. https://tud.qucosa.de/id/qucosa%3A25300.

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Ziel der vorliegenden Arbeit war die biologische Charakterisierung neuartiger nanostrukturierter und für die Knochenregeneration geeigneter Calciumphosphatzemente (CPC). Hierzu wurde ein aus α-Tricalciumphosphat, Calciumhydrogenphosphat, gefälltem Hydroxylapatit und Calciumcarbonat bestehender CPC verwendet, der mit den Biomolekülen Cocarboxylase, Glucuronsäure, Weinsäure, Glucose-1-phosphat, Arginin, Lysin und Asparaginsäure-Natriumsalz modifiziert wurde. Ermittelt wurde dabei der Einfluss der Modifikationen auf die Proteinadsorption und die Biokompatibilität. In Vorversuchen wurden die Zemen
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