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Journal articles on the topic 'Calvaria de rat'

Author: Grafiati

Published: 8 July 2023

Last updated: 31 July 2025

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1

Anavi, Yakir, Gal Avishai, Shlomo Calderon, and Dror M. Allon. "Bone Remodeling in Onlay Beta-Tricalcium Phosphate and Coral Grafts to Rat Calvaria: Microcomputerized Tomography Analysis." Journal of Oral Implantology 37, no. 4 (2011): 379–86. http://dx.doi.org/10.1563/aaid-joi-d-09-00128.1.

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Abstract This study was conducted to establish the efficiency of microcomputerized tomography (micro-CT) in detection of trabecular bone remodeling of onlay grafts in a rodent calvaria model, and to compare bone remodeling after onlay grafts with beta-tricalcium phosphate (TCP) or coral calcium carbonate. Ten rats received calvarial onlay blocks—5 with TCP and 5 with coral calcium carbonate. The grafts were fixed with a titanium miniplate screw and were covered with a collagen resorbable membrane. Three months after surgery, the calvaria were segmented, and a serial 3-dimensional micro-CT scan

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2

Apaza Alccayhuaman, Karol Ali, Patrick Heimel, Stefan Tangl, et al. "Human versus Rat PRF on Collagen Membranes: A Pilot Study of Mineralization in Rat Calvaria Defect Model." Bioengineering 11, no. 5 (2024): 414. http://dx.doi.org/10.3390/bioengineering11050414.

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Platelet-rich fibrin, the coagulated plasma fraction of blood, is commonly used to support natural healing in clinical applications. The rat calvaria defect is a standardized model to study bone regeneration. It remains, however, unclear if the rat calvaria defect is appropriate to investigate the impact of human PRF (Platelet-Rich Fibrin) on bone regeneration. To this end, we soaked Bio-Gide® collagen membranes in human or rat liquid concentrated PRF before placing them onto 5 mm calvarial defects in Sprague Dawley rats. Three weeks later, histology and micro-computed tomography (μCT) were pe

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3

Badwelan, Mohammed, Mohammed Alkindi, Osama Alghamdi, Abeer Ahmed, Sundar Ramalingam та Ali Alrahlah. "Bone Regeneration Using PEVAV/β-Tricalcium Phosphate Composite Scaffolds in Standardized Calvarial Defects: Micro-Computed Tomographic Experiment in Rats". Materials 14, № 9 (2021): 2384. http://dx.doi.org/10.3390/ma14092384.

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Bone regeneration using beta-tricalcium phosphate (β-TCP) can be practiced using a biocomposite scaffold. Poly(ethylene-co-vinylalcohol)/poly(δ-valerolactone)/β-tricalcium phosphate (PEVAV/β-TCP) composite scaffolds showed promising in vitro results. This study evaluated the bone regenerative potential of PEVAV/β-TCP biocomposite scaffolds in standardized calvarial defects in a rat model over 4 and 10 weeks. Bilateral calvarial defects (5 mm in diameter and about 1.5 mm thick, equivalent to the thickness of the calvaria) were created in 40 male Wistar albino rats. The defects were grafted with

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Allon, Irit, Yakir Anavi, and Dror M. Allon. "Topical Simvastatin Improves the Pro-Angiogenic and Pro-Osteogenic Properties of Bioglass Putty in the Rat Calvaria Critical-Size Model." Journal of Oral Implantology 40, no. 3 (2014): 251–58. http://dx.doi.org/10.1563/aaid-joi-d-11-00222.

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Objective was to describe the effect of bioactive glass putty with and without topical simvastatin on new bone formation in critical-sized defects of rat calvaria. A calvarial bone defect was created in 20 male Wistar rats and filled with bioactive glass alone (n = 10) or combined with simvastatin (n = 10). After 4 weeks, the defects were histomorphometrically evaluated for volume fraction (Vv) of woven bone, vessel density, bioglass quantity, and inflammation. Compared to the bioglass-only group, rats treated with simvastatin had greater Vv of blood vessels (3.3% ± 0.7 vs 1.6% ± 0.1, P = .000

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Ishimoto, Takuya, Tatsushi Sakamoto, and Takayoshi Nakano. "Orientation of Biological Apatite in Rat Calvaria Analyzed by Microbeam X-Ray Diffractometer." Materials Science Forum 638-642 (January 2010): 576–81. http://dx.doi.org/10.4028/www.scientific.net/msf.638-642.576.

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A microbeam X-ray diffractometer is a powerful tool to analyze oriented biological apatite (BAp) crystallites in bones since BAp orientation is one of the dominant controlling factors for bone mechanical function. The formation of BAp orientation seems to be partly affected by the bone formation process, including membranous or intracartilaginous ossification, the direction and the rate of bone growth, the mineral apposition rate, etc. However, the detailed process and the mechanisms of the organization of BAp orientation during the bone formation process are still not understood. In this stud

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Agarwal, M. K., F. Mirshahi, M. Mirshahi, et al. "Evidence for receptor-mediated mineralocorticoid action in rat osteoblastic cells." American Journal of Physiology-Cell Physiology 270, no. 4 (1996): C1088—C1095. http://dx.doi.org/10.1152/ajpcell.1996.270.4.c1088.

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Aldosterone significantly enhanced the proliferation of osteoblastic cells from rat calvaria, and this effect was inhibited by RU 26752 and ZK 91587, two antagonists specific to the mineralocorticoid receptor (MCR). In addition, aldosterone inhibited the activity of alkaline phosphatase, a marker of the osteoblastic phenotype, and this effect was also reversed by RU 26752. Cytoplasmic staining of MCR was observed in rat calvaria osteoblasts incubated with a specific polyclonal antiserum raised against rat kidney MCR. This anti-MCR immunoglobulin G immunoprecipitated and macroaggregated the MCR

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7

Kim, Yesel, and Jeong-Kui Ku. "Rat Calvaria Model Mimicking the Intraoral Lesion of Medication-Related Osteonecrosis in the Jaw: A Preliminary Test." Journal of Clinical Medicine 12, no. 21 (2023): 6731. http://dx.doi.org/10.3390/jcm12216731.

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Numerous preclinical intraoral models have been proposed to study medication-related osteonecrosis of the jaws (MRONJ). However, an extraoral animal model is necessary to investigate the effects of interventions such as grafts or direct therapeutics. This study aimed to establish a MRONJ rat model on the calvaria. Seven rats were allocated to either the control or MRONJ group. The MRONJ group received injections of zoledronic acid and dexamethasone to induce osteonecrosis over 4 weeks. Two weeks after these injections, the maxillary first molar was extracted, and two calvaria defects were crea

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8

Kim, Duck Hyun, Kang Sik Lee, Jung Hwa Kim, Jae Suk Chang, and Yung Tae Kim. "The Influence of Bioactive Glass Particles on Osteolysis." Key Engineering Materials 330-332 (February 2007): 193–96. http://dx.doi.org/10.4028/www.scientific.net/kem.330-332.193.

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We observed the cytotoxicity of human bone marrow stromal cells(hBMSCs) by microparticles of bioactive glass with four particle groups(same chemical composition-45S5 but produced by two different manufacturer and two different size groups). In vivo test using rat calvaria were also carried out. The apoptosis rates of all small particle groups(10-20 ㎛) were increased than large(500-700 ㎛ or 200-900 ㎛) particle groups in any culture time and any amount of particles with statistical significance. In vivo study we observed pathologic signs such as macrophages and foreign-body giant cells in rat ca

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9

Schmidt, Luis Eduardo, Henrique Hadad, Igor Rodrigues de Vasconcelos, et al. "Critical Defect Healing Assessment in Rat Calvaria Filled with Injectable Calcium Phosphate Cement." Journal of Functional Biomaterials 10, no. 2 (2019): 21. http://dx.doi.org/10.3390/jfb10020021.

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(1) Background: The tissue engineering field has been working to find biomaterials that mimic the biological properties of autogenous bone grafts. (2) Aim: To evaluate the osteoconduction potential of injectable calcium phosphate cement implanted in critical defects in rat calvaria. (3) Methods: In the calvarial bone of 36 rats, 7-mm diameter critical size defects were performed. Afterwards, the animals were randomly divided into three groups according to filler material: a blood clot group (BC), blood clot membrane group (BCM), and an injectable β-tricalcium phosphate group (HBS) cement group

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10

Han, Qingbin, Delu Zhao, Xiaohong Wang, et al. "Composite barrier membrane for bone regeneration: advancing biomaterial strategies in defect repair." RSC Advances 15, no. 2 (2025): 1290–99. https://doi.org/10.1039/d4ra07623k.

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11

Schmid, Christoph, Irene Schläpfer, Eva Futo, et al. "Triiodothyronine (T3) stimulates insulin-like growth factor (IGF)-1 and IGF binding protein (IGFBP)-2 production by rat osteoblasts in vitro." Acta Endocrinologica 126, no. 5 (1992): 467–73. http://dx.doi.org/10.1530/acta.0.1260467.

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Osteoblast-like cells prepared from neonatal rat calvariae and grown under serum-free conditions produce IGF-1 and IGFBPs. In contrast to growth hormone, T3 and PTH increased both IGF-1 mRNA expression and net IGF-1 release in calvaria cells. In addition, they stimulated net production of IGFBP-3 and of an IGFBP with an apparent molecular weight of 32 kDa which was recognized by an antiserum against rat IGFBP-2. Bone cells expressed remarkably high levels of mRNA for IGFBP-2, the predominant IGFBP in serum of newborn rats. T3 at low physiological concentrations but not growth hormone stimulate

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12

Nasirzade, Jila, Karol Alí Apaza Alccayhuaman, Zahra Kargarpour, et al. "Acid Dentin Lysate Failed to Modulate Bone Formation in Rat Calvaria Defects." Biology 10, no. 3 (2021): 196. http://dx.doi.org/10.3390/biology10030196.

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Autogenous tooth roots are increasingly applied as a grafting material in alveolar bone augmentation. Since tooth roots undergo creeping substitution similar to bone grafts, it can be hypothesized that osteoclasts release the growth factors stored in the dentin thereby influencing bone formation. To test this hypothesis, collagen membranes were either soaked in acid dentin lysates (ADL) from extracted porcine teeth or serum–free medium followed by lyophilization. Thereafter, these membranes covered standardized 5-mm-diameter critical-size defects in calvarial bone on rats. After four weeks of

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Silva, I. I. C., S. Pimentel-Soares, Rafael C. Bittencourt, and José Mauro Granjeiro. "Natural Bovine Anorganic Apatite and Collagen Presents Osteoconductivity and Contribute to Bone Repair of Rat Calvaria Critical Size Defect." Key Engineering Materials 396-398 (October 2008): 249–52. http://dx.doi.org/10.4028/www.scientific.net/kem.396-398.249.

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The aim of this study was verify the biological efficacy of the use of a xenograft for bone loss therapy. Blood clot, particulate autogenous bone or anorganic bovine xenograft filled critical size defects (CSD) in rat calvaria (8mm diameter). After 0, 7, 30 and 90 days the animals were killed and macroscopic, radiographic and histopathological analysis were conducted. Although no treatment promoted the total closure of bone defect, autogenous bone group had better bone repair after 90 days, followed by xenograft group that exhibited direct bone neoformation onto, and around, the particles conf

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14

Oldberg, A., B. Jirskog-Hed, S. Axelsson, and D. Heinegård. "Regulation of bone sialoprotein mRNA by steroid hormones." Journal of Cell Biology 109, no. 6 (1989): 3183–86. http://dx.doi.org/10.1083/jcb.109.6.3183.

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In this report we demonstrate an increase in the steady-state level of bone sialoprotein (BSP) mRNA in rat calvaria and a rat osteosarcoma cell line (ROS 17/2.8) after treatment with the synthetic glucocorticoid, dexamethasone. In contrast, 1.25-dihydroxyvitamin D3 reduced the amount of BSP mRNA in calvaria and inhibited the dexamethasone induction in ROS 17/2.8 cells. The increase in BSP mRNA is most likely due to an increase in the transcriptional rate. The stability of mRNA was unchanged after dexamethasone treatment with a half-life of approximately 5 h. Nuclear transcription experiments w

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15

Raposo-Amaral, Cassio Eduardo, Ana Beatriz Albino de Almeida, Gustavo Paschoal, et al. "Histological and radiological changes in cranial bone in the presence of bone wax." Acta Cirurgica Brasileira 26, no. 4 (2011): 274–78. http://dx.doi.org/10.1590/s0102-86502011000400005.

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PURPOSE: To quantify the amount of bone formation in the calvarial region of Wistar rats after craniotomy using bone wax as a haemostatic agent. METHODS: Surgery to produce bilateral, symmetric, full-thickness cranial defects (area: 18 mm²) was performed in eight animals. The right side of the cranium remained open and the edges of the left side osseous defect was covered with bone wax. Calvaria were imaged immediately after surgery and 12 weeks postoperatively by computerized tomography. The areas of the bone defects were measured in three-dimensional images using Magics 13.0 (Materialise-Bel

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16

Cornish, Jillian, Karen E. Callon, David H. Coy, et al. "Adrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo." American Journal of Physiology-Endocrinology and Metabolism 273, no. 6 (1997): E1113—E1120. http://dx.doi.org/10.1152/ajpendo.1997.273.6.e1113.

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Adrenomedullin is a 52-amino acid vasodilator peptide produced in many tissues, including bone. It has 20% sequence identity with amylin, a regulator of osteoblast growth, and circulates in picomolar concentrations. The present study assesses whether adrenomedullin also acts on osteoblasts. At concentrations of 10−12 M and greater, adrenomedullin produced a dose-dependent increase in cell number and [3H]thymidine incorporation in cultures of fetal rat osteoblasts. This effect was also seen with adrenomedullin-(15—52), -(22—52), and -(27—52), but adrenomedullin-(40—52) was inactive. These effec

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17

NAKAMURA, Hiroaki, Azumi HIRATA, Takehito TSUJI, and Toshio YAMAMOTO. "Immunolocalization of Keratan Sulfate Proteoglycan in Rat Calvaria." Archives of Histology and Cytology 64, no. 1 (2001): 109–18. http://dx.doi.org/10.1679/aohc.64.109.

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18

Fukae, Makoto, Takako Tanabe, and Marie Yamada. "Mineralized phase matrix proteinases of newborn rat calvaria." Journal of Bone and Mineral Metabolism 8, no. 3 (1990): 12–18. http://dx.doi.org/10.1007/bf02377368.

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19

Nefussi, Jean R., Gabriel Brami, Dominique Modrowski, Martine Obcuf, and Nadine Forest. "Sequential Expression of Bone Matrix Proteins During Rat Calvaria Osteoblast Differentiation and Bone Nodule Formation In Vitro." Journal of Histochemistry & Cytochemistry 45, no. 4 (1997): 493–503. http://dx.doi.org/10.1177/002215549704500402.

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We investigated the expression of osteocalcin (OC), bone sialoprotein (BSP), osteonectin (ON), and alkaline phosphatase (ALP) during cell differentiation and bone nodule formation by fetal rat calvaria cells, using immunofluorescent and immunogold techniques at light and electron microscopic levels. Six hours after plating all proteins were expressed in calvaria cells. However, expression was not detected during the proliferation phase after plating. Cell morphological modifications were observed in osteoblastic cells expressing ALP, OC, and BSP, but not ON. During the matrix formation phase,

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20

Lima, Julia Raulino, Priscilla Barbosa Ferreira Soares, Lucas de Souza Goulart Pereira, Leidys Rodríguez Perdomo, Suzane Cristina Pigossi, and Guilherme José Pimentel Lopes de Oliveira. "Histomorphometric comparison of two different preclinical models to evaluate the bone repair in grafted areas." Brazilian Journal of Oral Sciences 23 (June 3, 2024): e243937. http://dx.doi.org/10.20396/bjos.v23i00.8673937.

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Aim: This study was performed to compare two different rat defect models (critical calvaria defects versus guided bone regeneration in the mandibular ramus) used to evaluate bone repair in grafted areas. Methods: A total of 12 rats were allocated in two groups according the experimental model used to evaluate the bone repair in grafted areas: a critical sized-calvaria defect of 5 mm filled with bone graft (n=6) and a mandibular ramus filled with the bone graft associated with a Teflon dome-shaped membrane (n=6). Both groups were grafted with deproteinized bovine bone graft. After 60 days, the

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21

Freitas, Gileade P., Helena B. Lopes, Alann T. P Souza, et al. "Effect of cell therapy with osteoblasts differentiated from bone marrow or adipose tissue stromal cells on bone repair." Regenerative Medicine 14, no. 12 (2019): 1107–19. http://dx.doi.org/10.2217/rme-2019-0036.

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Aim: The aim of this study was to investigate the effect of local injection of osteoblasts differentiated from bone marrow (BM-OB) or adipose tissue (AT-OB) mesenchymal stromal cells on bone tissue formation. Materials & methods: Defects were created in rat calvaria and injected with BM-OB or AT-OB and phosphate-buffered saline without cells were injected as control. Bone formation was evaluated 4 weeks postinjection. Results: Injection of BM-OB or AT-OB resulted in higher bone formation than that obtained with control. The bone tissue induced by cell injections exhibited similar mechanica

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22

Ohya, Keiichi, Shoji Yamada, Rolf Felix, and Herbert Fleisch. "Effect of bisphosphonates on prostaglandin synthesis by rat bone cells and mouse calvaria in culture." Clinical Science 69, no. 4 (1985): 403–11. http://dx.doi.org/10.1042/cs0690403.

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1. Bisphosphonates are potent inhibitors of bone resorption and also inhibit prostaglandin (PG) E2 synthesis in bone cells. Therefore we have investigated whether a correlation exists between inhibition of bone resorption and inhibition of PGE2 formation. 2. Initially, bisphosphonates were tested for their effect on the release of [14C]PGE2 from rat calvaria cells labelled with [14C]arachidonic acid and stimulated by bradykinin, thrombin and mechanical manipulation. The effect on [14C]-PGE2 synthesis was not correlated with the known inhibitory activity of bisphosphonates on bone resorption. 3

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23

Ljunggren, Östen, and Sverker Ljunghall. "Carboxyterminal telopeptide of type I collagen, ICTP, as a marker of matrix degradation in neonatal mouse calvarial bones, in vitro." Bioscience Reports 12, no. 5 (1992): 407–11. http://dx.doi.org/10.1007/bf01121504.

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Bone resorption, in vitro, is often measured as the release of prelabelled45Ca from neonatal mouse calvarial bones, or from fetal rat long bones. In this report we describe a technique to measure the breakdown of bone-matrix, in vitro. We also describe a new way to dissect neonatal mouse calvarial bones, in order to obtain large amounts of bone samples. Twelve bone fragments were dissected out from each mouse calvaria and were thereafter cultured in CMRL 1066 culture medium in serum-free conditions in 0.5 cm2 multiwell culture dishes. Matrix degradation after treatment with parathyroid hormone

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Fujimoto, R., H. E. Takahashi, T. Tanizawa, N. Yamamoto та K. Tokunaga. "Effect of transforming growth factor-β on rat calvaria". Bone 13, № 5 (1992): A11. http://dx.doi.org/10.1016/8756-3282(92)90501-m.

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25

Schuster, George S., Norris L. O'Dell, John T. Wilson, and David C. Ward. "Replication of rat virus in neonatal calvaria in culture." In Vitro Cellular & Developmental Biology 24, no. 10 (1988): 1042–46. http://dx.doi.org/10.1007/bf02620879.

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26

Walenga, Ronald W., and William Bergstrom. "Stimulation of calcium uptake in rat calvaria by prostacyclin." Prostaglandins 29, no. 2 (1985): 191–202. http://dx.doi.org/10.1016/0090-6980(85)90201-1.

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27

Brasileiro, Ravel Bezerra, Edgar Pereira Carreiro Junior, Zildenilson da Silva Sousa, Eduardo Diogo Gurgel-Filho, Fabio de Almeida-Gomes, and Roberta Barroso Cavalcante. "Histological Response and Bone Neoformation of Bioceramic Cements in Rat Calvaria." Journal of Advances in Medicine and Medical Research 37, no. 4 (2025): 1–13. https://doi.org/10.9734/jammr/2025/v37i45775.

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Aims: This study evaluated the level of inflammatory infiltrate, vasodilation, granulation tissue, and bone regeneration of two repair materials: White MTA (Angelus, Londrina, Brazil) and Bio-C Repair (Angelus, Londrina, Brazil) in rat calvaria. Study Design: This is an in vivo study with a sample of adult Wistar rats, approximately three months old and weighing between 250 and 300 grams. Place and Duration of Study: The selected analysis periods were 7, 30, and 60 days, corresponding to the following divisions: Group 1 (7 days): 5 rats; Group 2 (30 days): 5 rats; Group 3 (60 days): 5 rats. Me

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Sundar, Ramalingam, A. Bhagavandas Rai, Naveenkumar Jayakumar, and Darshan D. Divakar. "Calvarial bone defect regeneration using beta-tricalcium phosphate: a translational research study in rat animal model." International Journal of Research in Medical Sciences 10, no. 11 (2022): 2420. http://dx.doi.org/10.18203/2320-6012.ijrms20222836.

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Background: Guided bone regeneration (GBR) using osteoconductive graft materials has been used for osseous defect healing. The aim of this translational research study was to design and test a critical size calvarial defect (CSD) model in rats, to test GBR with beta-tricalcium phosphate (beta-TCP), using histology and micro computed tomography (micro-CT) assessment.Methods: Female Wistar albino rats (n=10) weighing 300 grams and aged 6-weeks were used and full thickness CSD were created in calvaria following exposure under general anesthesia. CSD were randomly divided into two groups for treat

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Hirsch, Wâneza Dias Borges, Alexandre Weber, Janaine Ferri, et al. "An Analysis of the Biocompatibility, Cytotoxicity, and Bone Conductivity of Polycaprolactone: An In Vivo Study." Polymers 16, no. 16 (2024): 2271. http://dx.doi.org/10.3390/polym16162271.

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Background: Tissue engineering represents a promising field in regenerative medicine, with bioresorbable polymers such as polycaprolactone (PCL) playing a crucial role as scaffolds. These scaffolds support the growth and repair of tissues by mimicking the extracellular matrix. Objective: This study aimed to assess the in vivo performance of three-dimensional PCL scaffolds by evaluating their effects on bone repair in rat calvaria and the tissue reaction in subcutaneous implant sites, as well as their impact on major organs such as the kidneys, lungs, and liver. Methods: Three-dimensional scaff

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Bonnelye, Edith, Vanessa Kung, Catherine Laplace, Deborah L. Galson та Jane E. Aubin. "Estrogen Receptor-Related Receptor α Impinges on the Estrogen Axis in Bone: Potential Function in Osteoporosis". Endocrinology 143, № 9 (2002): 3658–70. http://dx.doi.org/10.1210/en.2002-220095.

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Abstract The orphan nuclear estrogen receptor-related receptor α (ERRα) is expressed by osteoblastic cells and plays a functional role in osteoprogenitor proliferation and differentiation. To dissect further the role of ERRα in bone, we investigated the effects of estrogen (E2) on ERRα both in vitro and in vivo. Chronic treatment of fetal rat calvaria cells with E2-stimulated bone nodule formation and up-regulated ERRα mRNA expression at early (10 h and d 8) but not later times in culture, suggesting a link between ERRα and E2 during osteoprogenitor proliferation. ERRα mRNA levels were signifi

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TSAI, SHIAO-WEN, FU-YIN HSU, and YNG JIIN WANG. "ENCAPSULATION AND GROWTH CHARACTERISTICS OF THREE DIFFERENT CELLS IN ALGINATE GEL BEADS CONTAINING RECONSTITUTED COLLAGEN FIBERS." Biomedical Engineering: Applications, Basis and Communications 18, no. 02 (2006): 62–66. http://dx.doi.org/10.4015/s1016237206000129.

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Alginate gel beads containing reconstituted collagen fibers were fabricated and used to culture three different cells - GH3 pituitary tumor cells, L929 fibroblasts and rat calvaria osteoblasts. These cells when entrapped within the collagen-containing alginate behaved differently from those grown in the alginate matrix. Of the three cells tested, the existence of collagen fibers is most beneficial for the viability and proliferation of GH3 cells which can grow either as suspended or attached to the matrix. For the case of osteoblasts derived from the primary culture of rat calvaria, most of th

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Monção, Mauricio Mitsuo, Carina Soares do Nascimento, Isabela Cerqueira Barreto, and Roberto Paulo Correia de Araújo. "Analysis of surface morphology and elemental composition in a glass-ceramic implanted in rat calvaria using MEV and EDX." Concilium 24, no. 16 (2024): 96–109. http://dx.doi.org/10.53660/clm-3904-24q28.

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The objective of this study was to analyze the surface morphology and elemental composition of a glass-ceramic developed with different proportions of wollastonite (W) and tricalcium phosphate (TCP) implanted in a rat calvaria. The glass-ceramic was prepared with a mixture of W and TCP powders in proportions (W%/TCP%) equal to 20/80%, 60/40% and 80/20%, followed by sintering and processing to obtain granules with sizes between 400 and 600 μm, which were implanted in rat calvaria and analyzed at biological points of 7, 15 and 45 days after implantation. For morphological analysis, the samples w

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Maccarinelli, Giuseppina, Valeria Sibilia, Antonio Torsello, et al. "Ghrelin regulates proliferation and differentiation of osteoblastic cells." Journal of Endocrinology 184, no. 1 (2005): 249–56. http://dx.doi.org/10.1677/joe.1.05837.

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It has previously been reported that growth hormone secretagogues (GHS) may have a role in the regulation of bone metabolism in animals and humans. In this study we evaluated the effect of ghrelin, the endogenous ligand of GHS receptors, on the proliferation rate and on osteoblast activity in primary cultures of rat calvaria osteoblasts. In the same experiments, we compared the effects of ghrelin with those of hexarelin (HEXA) and EP-40737, two synthetic GHS with different characteristics. Both ghrelin and HEXA (10−11−10−8 M) significantly stimulated osteoblast proliferation at low concentrati

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Jang, Yong-Seok, So-Hee Moon, Thuy-Duong Thi Nguyen, et al. "In vivo bone regeneration by differently designed titanium membrane with or without surface treatment: a study in rat calvarial defects." Journal of Tissue Engineering 10 (January 2019): 204173141983146. http://dx.doi.org/10.1177/2041731419831466.

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The current objective was to evaluate six groups of titanium membranes in a rat calvarial defect model, regarding the surface treatment with or without calcium-phosphate coating and surface topography with no, small, or large holes. Critical size defects (Ф = 8 mm, n = 42) were surgically created in rat calvaria, and then were treated by one of the six groups. Biopsies were obtained at 4 weeks (n = 5 per group) for micro-computed tomography and histomorphometric analyses. Fluorochrome bone markers were injected in two rats each group at 1 (Alizarin red), 3 (Calcein green) and 5 weeks (Oxytetra

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Zambuzzi, Willian F., Gustavo V. O. Fernandes, Flávia G. Iano, Mileni da S. Fernandes, José Mauro Granjeiro, and Rodrigo Cardoso Oliveira. "Exploring anorganic bovine bone granules as osteoblast carriers for bone bioengineering: a study in rat critical-size calvarial defects." Brazilian Dental Journal 23, no. 4 (2012): 315–21. http://dx.doi.org/10.1590/s0103-64402012000400002.

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It is known that current trends on bone bioengineering seek ideal scaffolds and explore innovative methods to restore tissue function. In this way, the objective of this study was to evaluate the behavior of anorganic bovine bone as osteoblast carrier in critical-size calvarial defects. MC3T3-E1 osteoblast cells (1x10(5) cells/well) were cultured on granules of anorganic bovine bone in 24-well plates and after 24 h these granules were implanted into rat critical-size calvarial defects (group Biomaterial + Cells). In addition, other groups were established with different fillings of the defect:

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Iwai, Satoshi, Kayo Kuyama, Noboru Kuboyama, et al. "Osteogenic Potential of Human Dental Follicle Cells on Rat Calvaria." Journal of Hard Tissue Biology 22, no. 1 (2013): 95–104. http://dx.doi.org/10.2485/jhtb.22.95.

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Yoshiko, Yuji, Norihiko Maeda, and Jane E. Aubin. "Stanniocalcin 1 Stimulates Osteoblast Differentiation in Rat Calvaria Cell Cultures." Endocrinology 144, no. 9 (2003): 4134–43. http://dx.doi.org/10.1210/en.2003-0130.

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Lee, Won-Bum, Caifeng Wang, Jung-Han Lee, et al. "Whitlockite Granules on Bone Regeneration in Defect of Rat Calvaria." ACS Applied Bio Materials 3, no. 11 (2020): 7762–68. http://dx.doi.org/10.1021/acsabm.0c00960.

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Kasahara, Shinji, Seiji Nishikawa, Hiroshi Ishida, et al. "The role of 5′-methylthioadenosine on rat calvaria cell differentiation." Biochemical and Biophysical Research Communications 182, no. 2 (1992): 817–23. http://dx.doi.org/10.1016/0006-291x(92)91805-z.

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Massas, Ruth, Rafi Korenstein, Dieter Bincmann, and Peter Tetsch. "Membrane potential of rat calvaria bone cells: Dependence on temperature." Journal of Cellular Physiology 144, no. 1 (1990): 1–11. http://dx.doi.org/10.1002/jcp.1041440102.

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Adamek, G., R. Felix, H. L. Guenther, and H. Fleisch. "Fatty acid oxidation in bone tissue and bone cells in culture. Characterization and hormonal influences." Biochemical Journal 248, no. 1 (1987): 129–37. http://dx.doi.org/10.1042/bj2480129.

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Fatty acid oxidation and its hormonal modulation were investigated in cultured rat calvaria and in cultivated cell populations. The latter were obtained from calvaria of newborn rats by sequential time-dependent digestion with collagenase, yielding eight cell populations: the early ones containing mainly fibroblasts, the middle ones being osteoblast-like, and late ones osteoblast-osteocyte-like. In calvaria, fatty acid oxidation was increased by adding 0.1 mM- and 1.0 mM-palmitate to the medium, containing 10% (v/v) fetal-calf serum. No effect was found after parathyrin addition in vitro or wh

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Calasans-Maia, Monica, G. V. O. Fernandes, Antonella M. Rossi, et al. "Effect of Hydroxyapatite and Zinc-Containing Hydroxyapatite on Osseous Repair of Critical Size Defect in the Rat Calvaria." Key Engineering Materials 361-363 (November 2007): 1273–76. http://dx.doi.org/10.4028/www.scientific.net/kem.361-363.1273.

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Hydroxyapatite (HA), widely used as bone graft, can be modified by the incorporation of bivalent cations (Mg2+ and Zn2+) and its gradual release could favor the bone repair. The purpose of this research was to evaluate the effect of the HA and zinc-containing hydroxyapatite (Zn-HA) in the bone repair in rat calvaria in comparison to autogenous bone. Critical size defect in the calvaria was filled with the graft material and the samples were harvested at the 30, 90 and 180 days. The light microcopy observations showed the biocompatibility of the graft materials. In the Zn-HA group the area of n

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Araùjo, Carlos R. G., Carlo Astarita, Riccardo D'Aquino, and André A. Pelegrine. "Evaluation of Bone Regeneration in Rat Calvaria Using Bone Autologous Micrografts and Xenografts: Histological and Histomorphometric Analysis." Materials 13, no. 19 (2020): 4284. http://dx.doi.org/10.3390/ma13194284.

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The aim of this study was to investigate the effect of the use of autologous micrografts obtained by the Rigenera® Micrografting Technology and xenograft on critical size defects created in the calvaria of rats. Forty-eight rats were randomly divided into four groups for each of the two evaluation times (15 and 30 days) (n = 6). After general anesthesia, a 5-mm diameter bone defect was created in the calvaria of each animal. Each defect was filled with the following materials: blood clot, autologous bone graft, xenograft, and xenograft associated with autologous micrografts. Histomorphometric

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Biewer, Bob, Eric Rompen, Michel Mittelbronn, Gaël P. Hammer, Pascale Quatresooz, and Felix Kleine Borgmann. "Effects of Minocycline Hydrochloride as an Adjuvant Therapy for a Guided Bone Augmentation Procedure in The Rat Calvarium." Dentistry Journal 11, no. 4 (2023): 92. http://dx.doi.org/10.3390/dj11040092.

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This in vivo study reports the influence of minocycline-HCl administration on extra-skeletal bone generation in a Guided Bone Augmentation model, utilizing titanium caps placed on the intact as well as perforated calvaria of rats. The test group was administered 0.5 mg/mL minocycline-HCl with the drinking water, and the amount of bone tissue in the caps was quantified at three time points (4, 8 and 16 weeks). A continuously increased tissue fill was observed in all groups over time. The administration of minocycline-HCl as well as perforation of the calvaria increased this effect, especially w

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Dalla Costa, Karen L., Juliana Lacerda Dias, Izaura M. Crunivel Araújo, et al. "Local application of melatonin associated or not to xenogeneic material, in critical defects of rat calvaria." Acta Odontológica Latinoamericana 37, no. 2 (2024): 123–33. http://dx.doi.org/10.54589/aol.37/2/123.

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Melatonin (MLT) is a hormone that can stimulate bone formation and inhibit bone resorption, among other functions. Aim: To evaluate the effect on new bone formation of MLT applied locally to critical defects created in the calvaria of rats, compared to the effect of Bio-Oss® xenogeneic bone substitute (BO), by analyzing histomorphometry, microtomography and gene expression. Materials and Method: Two critical defects (5.0 mm in diameter) were created in the calvaria of 36 adults male Wistar rats. The rats were divided randomly into two groups: a test group, in which one of the defects was fille

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Lee, Dong Joon, Yonsil Park, Wei-Shou Hu, and Ching-Chang Ko. "Osteogenic Potential of Multipotent Adult Progenitor Cells for Calvaria Bone Regeneration." Advances in Medicine 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/2803081.

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Osteogenic cells derived from rat multipotent adult progenitor cells (rMAPCs) were investigated for their potential use in bone regeneration. rMAPCs are adult stem cells derived from bone marrow that have a high proliferation capacity and the differentiation potential to multiple lineages. They may also offer immunomodulatory properties favorable for applications for regenerative medicine. rMAPCs were cultivated as single cells or as 3D aggregates in osteogenic media for up to 38 days, and their differentiation to bone lineage was then assessed by immunostaining of osteocalcin and collagen typ

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Câmara-Pereira, Eliana dos Santos, Ana Emília Holanda Rolim, Evelyn Reale, et al. "Analysis of Bone Repair Tissue after Implantation of Biomaterials and Application of Vibratory Waves." Materials Science Forum 775-776 (January 2014): 9–12. http://dx.doi.org/10.4028/www.scientific.net/msf.775-776.9.

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Bone tissue in ideal conditions morphofunctional remodeling properly. The bone can be affected by fractures, tumors, hormonal dysfunction, senescence, genetic modifications, among others. In such circumstances, the proper diet, drug use, exercise and other factors are important to the prevention of bone mineral loss. The effect of kinesiotherapy obtained through the application of vibratory waves administered through the vibrating platform, Juvent1000 ® already been established in the prevention of bone mineral density, muscular trophism, among other systems in humans. The response by analyzin

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Al Qabbani, Ali, K. G. Aghila Rani, Sausan AlKawas, et al. "Evaluation of the osteogenic potential of demineralized and decellularized bovine bone granules following implantation in rat calvaria critical-size defect model." PLOS ONE 18, no. 12 (2023): e0294291. http://dx.doi.org/10.1371/journal.pone.0294291.

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The aim of this study was to compare the ability of demineralized (DMB) and decellularized (DCC) bovine bone granules to support bone regeneration in rat calvaria critical-size defects. DMB and DCC were prepared using a previously published method. The granule size used ranged between 500 and 750 μm. A total of forty-eight Sprague-Dawley rats were divided into two groups (n = 24). A pair of 5 mm diameter defects were created on the calvaria of the rats in the right and left parietal bone in both groups. Group A animals received DMB granules and Group B received DCC granules in the right pariet

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Schneider Werner Vianna, Thiago, Suelen Cristina Sartoretto, Adriana Terezinha Neves Novellino Alves, et al. "Nanostructured Carbonated Hydroxyapatite Associated to rhBMP-2 Improves Bone Repair in Rat Calvaria." Journal of Functional Biomaterials 11, no. 4 (2020): 87. http://dx.doi.org/10.3390/jfb11040087.

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Many biomaterials are used for Bone Morphogenetic Proteins (BMPs) delivery in bone tissue engineering. The BMP carrier system’s primary function is to hold these growth factors at the wound’s site for a prolonged time and provide initial support for cells to attach and elaborate the extracellular matrix for bone regeneration. This study aimed to evaluate the nanostructured carbonated hydroxyapatite microspheres (nCHA) as an rhBMP-2 carrier on rats calvaria. A total of fifteen male Wistar rats were randomly divided into three groups (n = 5): clot (control group), rhBMP-2 associated with collage

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Schmid, Ch, Th Steiner, and E. R. Froesch. "Triiodothyronine increases responsiveness of cultured rat bone cells to parathyroid hormone." Acta Endocrinologica 111, no. 2 (1986): 213–16. http://dx.doi.org/10.1530/acta.0.1110213.

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Abstract. Osteoblast-like cells prepared from calvaria of newborn rats and grown in culture for 1 week show markedly increased ornithine decarboxylase (ODC) activity upon exposure to parathyroid hormone (PTH) for 4 h. Triiodothyronine (T3) increases ODC activity of the cultures in long-term experiments but does not stimulate cell replication. Moreover, PTH responsiveness is enhanced by T3. Thus, T3 acts directly on bone cells, and the clinical observation of bone sensitization to PTH by thyroid hormones is confirmed at the cellular level.

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