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Journal articles on the topic 'CAM'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Picone, Carmela M., James C. Grotta, Rosa Earls, Roger Strong, and John Dedman. "Immunohistochemical Determination of Calcium—Calmodulin Binding Predicts Neuronal Damage after Global Ischemia." Journal of Cerebral Blood Flow & Metabolism 9, no. 6 (1989): 805–11. http://dx.doi.org/10.1038/jcbfm.1989.114.

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Since ionic Ca2+ binds with intracellular calmodulin (CaM) before activating proteases, kinases, and phospholipases, demonstration of persistent Ca2+ –CaM binding in neurons destined to show ischemic cellular injury would support the concept that elevated intracellular Ca2+ plays a causative role in ischemic neuronal damage. In order to characterize Ca2+ –CaM binding, we used a sheep anti-CaM antibody (CaM-Ab) which recognizes CaM that is not bound to Ca2+ or brain target proteins. Therefore, immunohistochemical staining of brain sections by labeled CaM-Ab represented only unbound CaM. Six nor

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Babu, Numbury Surendra, and Didugu Jayaprakash. "Computational Study of the Stability of Tautomers and equilibrium constants of Cyanuric acid (CA) in Different solvents." JOURNAL OF ADVANCES IN CHEMISTRY 11, no. 2 (2015): 3485–97. http://dx.doi.org/10.24297/jac.v11i2.6691.

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In the present investigation, the tautomeric and equilibrium of Cyanuric acid has been studied using Hartifock (HF) method in the gas phase and different solvents using the PCM model. The relative energies of these tautomers have been calculated at the HF level of theory using 6-311++ G (d,p) basis set. Energetics and relative stabilities of the tautomers were compared and analyzed in both the gaseous and different solvents. The results indicate that the keto tautomer (CA1) is the most stable form in the gas phase and other solvents. The order of stability of isomers was found to be CA1 > C

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3

Ge, Zheng Hao, Wei Huang, Wei Hua Liu, and Zhi Heng Zhai. "CAD/CAM/CAE for the Parallel Indexing Cam Mechanisms." Applied Mechanics and Materials 44-47 (December 2010): 475–79. http://dx.doi.org/10.4028/www.scientific.net/amm.44-47.475.

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This paper takes the parallel indexing cam mechanism as research object and analyzes the formation of the profile of cam. On the basis of Visual C++6.0 object-oriented method, we have successfully developed the CAD/CAE/CAM system of parallel indexing cam mechanisms, which provides the parameter input dialogue frame with friendly interface. We can generate accurate profile data by using it, then create the three-dimensional model of the parallel indexing cam and assemble it with other parts under the Pro/E environment. At last, we don’t build virtual prototype until we transform the model into

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4

RUBANKA, Mykola, Volodymyr DVORZHAK, Zhyhad ZHLALI, YURYJ SHCHERBAN, and VOLODYMYR ONOFRIICHUK. "FEATURES OF THE USE OF MODERN AUTOMATED PROJECTING SYSTEMS OF MACHINE-BUILDING INDUSTRIES." Herald of Khmelnytskyi National University. Technical sciences 329, no. 6 (2023): 38–44. http://dx.doi.org/10.31891/2307-5732-2023-329-6-38-43.

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The purpose of the study covered in this publication is to analyze the features of the use of modern automated projecting systems, in particular CAD/CAM/CAE technologies from the point of view of the feasibility of introducing into the technological process of manufacturing products of a machine-building enterprise. The most popular specialized integrated CAD/CAM/CAE systems of the highest category for solving design and technological problems of varying complexity are listed, the features of their use are revealed, the main advantages and disadvantages and the most significant functionality a

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Babcock, Donner F., James Herrington, Paul C. Goodwin, Young Bae Park, and Bertil Hille. "Mitochondrial Participation in the Intracellular Ca2+ Network." Journal of Cell Biology 136, no. 4 (1997): 833–44. http://dx.doi.org/10.1083/jcb.136.4.833.

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Calcium can activate mitochondrial metabolism, and the possibility that mitochondrial Ca2+ uptake and extrusion modulate free cytosolic [Ca2+] (Cac) now has renewed interest. We use whole-cell and perforated patch clamp methods together with rapid local perfusion to introduce probes and inhibitors to rat chromaffin cells, to evoke Ca2+ entry, and to monitor Ca2+-activated currents that report near-surface [Ca2+]. We show that rapid recovery from elevations of Cac requires both the mitochondrial Ca2+ uniporter and the mitochondrial energization that drives Ca2+ uptake through it. Applying imagi

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Kubota, Yoshihisa, John A. Putkey, Harel Z. Shouval, and M. Neal Waxham. "IQ-Motif Proteins Influence Intracellular Free Ca2+ in Hippocampal Neurons Through Their Interactions With Calmodulin." Journal of Neurophysiology 99, no. 1 (2008): 264–76. http://dx.doi.org/10.1152/jn.00876.2007.

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Calmodulin (CaM) is most recognized for its role in activating Ca2+–CaM-dependent enzymes following increased intracellular Ca2+. However, CaM's high intracellular concentration indicates CaM has the potential to play a significant role as a Ca2+ buffer. Neurogranin (Ng) is a small neuronal IQ-motif–containing protein that accelerates Ca2+ dissociation from CaM. In cells that contain high concentrations of both Ng and CaM, like CA1 pyramidal neurons, we hypothesize that the accelerated Ca2+ dissociation from CaM by Ng decreases the buffering capacity of CaM and thereby shapes the transient dyn

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Todorovic, Aleksandar, and Vojkan Lazic. "Computer aided design and manufacturing of dental restorations - “computerized impression” technology." Serbian Dental Journal 53, no. 1 (2006): 42–53. http://dx.doi.org/10.2298/sgs0601042t.

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CAD/CAM technology (Computer Aided Design / Computer Aided Manufacturing) in the matter of fact helps in design and development of two-dimensional or three-dimensional models and their realization on numerical controlled machines. The key to direct or indirect CAD/CAM dental restorations is the measurement of dental preparation in the mouth or on the plaster die. The aim of this paper is to describe the possibilities and the way of function of different computer aided inspection (CAI) systems as a first part of CAD/CAM systems. Different researchers have presented several approaches of methods

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8

Rojas Lazo, Oswaldo, and Julio Salas Bacalla. "PRODUCCIÓN AUTOMATIZADA SISTEMAS CAD/CAE/CAM." Industrial Data 2, no. 1 (2014): 38. http://dx.doi.org/10.15381/idata.v2i1.6469.

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<span>El presente artículo muestra los resultados de la investigación realizada por los autores sobre el tema y proponen la creación de un laboratorio de producción automatizada con tres áreas definidas: Confecciones, Calzado y Control Numérico.</span>

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9

Kyratsis, Panagiotis, Konstantinos Kakoulis, and Angelos P. Markopoulos. "Advances in CAD/CAM/CAE Technologies." Machines 8, no. 1 (2020): 13. http://dx.doi.org/10.3390/machines8010013.

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10

Ali, Nur Shidaa Mohd, Abu Bakar Salleh, Thean Chor Leow, Raja Noor Zaliha Raja Abd Rahman, and Mohd Shukuri Mohamad Ali. "The Influence of Calcium toward Order/Disorder Conformation of Repeat-in-Toxin (RTX) Structure of Family I.3 Lipase from Pseudomonas fluorescens AMS8." Toxins 12, no. 9 (2020): 579. http://dx.doi.org/10.3390/toxins12090579.

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Calcium-binding plays a decisive role in the folding and stabilization of many RTX proteins, especially for the RTX domain. Although many studies have been conducted to prove the contribution of Ca2+ ion toward the folding and stabilization of RTX proteins, its functional dynamics and conformational structural changes remain elusive. Here, molecular docking and molecular dynamics (MD) simulations were performed to analyze the contribution of Ca2+ ion toward the folding and stabilization of the RTX lipase (AMS8 lipase) structure. AMS8 lipase contains six Ca2+ ions (Ca1–Ca6). Three Ca2+ ions (Ca

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11

KASE, Kiwamu. "An Introduction of Outline of CAD/CAE/CAM/CAT (1)." Journal of the Japan Society for Precision Engineering 79, no. 2 (2013): 144–47. http://dx.doi.org/10.2493/jjspe.79.144.

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KASE, Kiwamu. "An Introduction of Outline of CAD/CAE/CAM/CAT (2)." Journal of the Japan Society for Precision Engineering 79, no. 3 (2013): 223–26. http://dx.doi.org/10.2493/jjspe.79.223.

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13

KASE, Kiwamu. "An Introduction of Outline of CAD/CAE/CAM/CAT (3)." Journal of the Japan Society for Precision Engineering 79, no. 4 (2013): 309–13. http://dx.doi.org/10.2493/jjspe.79.309.

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14

Wang, J. H., and P. T. Kelly. "Regulation of synaptic facilitation by postsynaptic Ca2+/CaM pathways in hippocampal CA1 neurons." Journal of Neurophysiology 76, no. 1 (1996): 276–86. http://dx.doi.org/10.1152/jn.1996.76.1.276.

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1. Current- and voltage-clamp recordings with simultaneous field potential recordings were used to study the cellular and molecular mechanisms that contribute to synaptic facilitation at CA1 synapses in rat hippocampal slices. Microelectrodes used for intracellular recordings were also used to inject modulators of intracellular signal pathways into postsynaptic CA1 neurons. 2. Paired-pulse stimulation at constant stimulus intensity was used to analyze the relationship between the first evoked response (R1) and the absolute value of paired-pulse synaptic facilitation (R2-R1). The magnitudes of

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15

Wang, L. S., F. Wei, and H. Wang. "Based on the Target Track Cam Design Method and Numerical Solution Research." Applied Mechanics and Materials 143-144 (December 2011): 463–67. http://dx.doi.org/10.4028/www.scientific.net/amm.143-144.463.

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In this paper, a new design method of cam is developed .To illustrate this method,a car which adopts cam mechanism to achieve specific movements is designed. By establishing the relationship between the point coordinates of cam profile and the track through the relevant mathematical models, and using the infinitesimal elements method to solve the models, the discrete points coordinates of the cam profile are obtained. The displacement, velocity and acceleration of the direction arm are simulated by Pro/E. the accurate trace of cam profile can be obtained by the method. To make the CAD/CAE/CAM

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16

Haswendra, Aditya Reza. "AN OVERVIEW OF LAN/WLAN IN CAD/CAM/CAE APPLICATIONS." Journal of Mechanical Science and Engineering 7, no. 1 (2020): 007–11. http://dx.doi.org/10.36706/jmse.v7i1.35.

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Computer network is an interface of two or more computers that is built for the purpose of sharing, information, data, and resources. Computer network has nodes that serve as the origin, route, and receiver of data. Computer network is built using a combination of hardware and software. LANs and WLANs are the most common form of computer network and they are used intensively and extensively in CAD/CAM/CAE applications. This review talks about the latest implementation of LANs/WLANs in CAD/CAM/CAE applications, their limitations, and consideration for their usage. There are four aspects that a

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17

Prabhu, N., M. Dev Anand, and V. Sundar. "Integrated CAD/CAE/CAM System for Scorbot-ER Vu Plus Industrial Robot Manipulator." Applied Mechanics and Materials 389 (August 2013): 747–53. http://dx.doi.org/10.4028/www.scientific.net/amm.389.747.

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Robots are required to operate in different environmental conditions facing varieties of end-effector to perform the workspace interactions. This paper deals with integrated CAD/CAE/CAM system for SCORBOT-ER Vu plus Industrial robot manipulator. The DH (DenavitHartenberg) coordinate transformation method was used to perform the robot position analysis. The robot manipulator parametric solid models were constructed using Pro/ENGINEER (Pro/E). Pro/Mechanica was used to simulate the dynamic simulation and working space, CATIA was used to implement the cutting simulation, and the prototype was man

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18

Iadarola, Paul. "CAD-CAM." Journal of the American Dental Association 125, no. 8 (1994): 1052. http://dx.doi.org/10.14219/jada.archive.1994.0126.

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19

Haselden, Geoffrey. "CAD/CAM." International Journal of Refrigeration 10, no. 3 (1987): 131. http://dx.doi.org/10.1016/0140-7007(87)90001-6.

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20

Doorner, Mike. "CAD/CAM." Design Studies 7, no. 1 (1986): 52–53. http://dx.doi.org/10.1016/0142-694x(86)90012-8.

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21

Gambassi, G., R. G. Hansford, S. J. Sollott, B. A. Hogue, E. G. Lakatta, and M. C. Capogrossi. "Effects of acidosis on resting cytosolic and mitochondrial Ca2+ in mammalian myocardium." Journal of General Physiology 102, no. 3 (1993): 575–97. http://dx.doi.org/10.1085/jgp.102.3.575.

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Acidosis increases resting cytosolic [Ca2+], (Cai) of myocardial preparations; however, neither the Ca2+ sources for the increase in Cai nor the effect of acidosis on mitochondrial free [Ca2+], (Cam) have been characterized. In this study cytosolic pH (pHi) was monitored in adult rat left ventricular myocytes loaded with the acetoxymethyl ester (AM form) of SNARF-1. A stable decrease in the pHi of 0.52 +/- 0.05 U (n = 16) was obtained by switching from a bicarbonate buffer equilibrated with 5% CO2 to a buffer equilibrated with 20% CO2. Electrical stimulation at either 0.5 or 1.5 Hz had no effe

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22

Kuang, Wei Hua, and Li Si Chen. "Virtual Product Development and Reliability Design of Camera Cover." Key Engineering Materials 460-461 (January 2011): 40–43. http://dx.doi.org/10.4028/www.scientific.net/kem.460-461.40.

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The paper finished the design of injection molding by UG MoldWizard module, and realized numerical simulation and analysis of injection process by MoldFlow software. Best gate location was obtained. Fill time was deeply studied. Though the mold designing process, it completed the CAD/CAM/CAE integration of the injection molding, and achieved the optimal design of the mold. NC machining of the mold core was programmed by UG NX software. CAD/CAM/CAE greatly improved the development efficient of the mold.

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23

Szymanski, Pawel T., Grazyna Szymanska, and Raj K. Goyal. "Differences in calmodulin and calmodulin-binding proteins in phasic and tonic smooth muscles." American Journal of Physiology-Cell Physiology 282, no. 1 (2002): C94—C104. http://dx.doi.org/10.1152/ajpcell.00257.2001.

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To determine whether densities of calmodulin (CaM) and CaM-binding proteins are related to phasic and tonic behavior of smooth muscles, we quantified these proteins in the opossum esophageal body (EB) and lower esophageal sphincter (LES), which represent phasic and tonic smooth muscles, respectively. Gel electrophoresis, immunoprecipitation, Western blot, and hemagglutinin epitope-tagged CaM (HA-CaM) overlay assay with quantitative scanning densitometry and phosphorylation measurements were used. Total protein content in the two smooth muscles was similar (∼30 mg protein/g frozen tissue). Tota

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Shen, Mei, Ning Zhang, Sanduo Zheng, et al. "Calmodulin in complex with the first IQ motif of myosin-5a functions as an intact calcium sensor." Proceedings of the National Academy of Sciences 113, no. 40 (2016): E5812—E5820. http://dx.doi.org/10.1073/pnas.1607702113.

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The motor function of vertebrate myosin-5a is inhibited by its tail in a Ca2+-dependent manner. We previously demonstrated that the calmodulin (CaM) bound to the first isoleucine-glutamine (IQ) motif (IQ1) of myosin-5a is responsible for the Ca2+-dependent regulation of myosin-5a. We have solved the crystal structure of a truncated myosin-5a containing the motor domain and IQ1 (MD-IQ1) complexed with Ca2+-bound CaM (Ca2+-CaM) at 2.5-Å resolution. Compared with the structure of the MD-IQ1 complexed with essential light chain (an equivalent of apo-CaM), MD-IQ1/Ca2+-CaM displays large conformatio

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Jin, Zhi Gang, Wu Ji Jiang, and Min Xia Yu. "Design and Manufacturing of Air Conditioner Panel Hot Runner Injection Mold Based on CAD/CAE/CAM." Applied Mechanics and Materials 42 (November 2010): 68–72. http://dx.doi.org/10.4028/www.scientific.net/amm.42.68.

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Take air conditioner panel for example, it is introduced that the whole process of hot runner injection mold design and manufacture based on CAD/CAE/CAM technology. The panel structure and injection process were analyzed using HuaSu CAE software, then the panel structure was designed using UG/Mold Wizard software, the NC programming and manufacture simulating of the formed parts were done by UG/MACHINE module at last. Compared with the traditional mold design method, CAD/CAE/CAM technology not only can improve the efficiency, shorten production period, but also can reduce the cost of mold desi

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Katoh, Hiroshi. "Simulation Advancement in Automotive Development: A Brief Review." Applied Mechanics and Materials 761 (May 2015): 22–26. http://dx.doi.org/10.4028/www.scientific.net/amm.761.22.

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The automotive development process is advancing through the utilization of CAD/CAM/CAE. This advancement is being enhanced by proper utilization of CAD/CAM integration, Digital prototyping and Digital mock-up. Until recently, CAD has played the leading role for the digitalization of automotive development. However, recent trend shows that, the leading role is shifted from CAD to analysis simulation. Three-dimensional design, which utilizes digital mock-up, is becoming the main tool for product design. Here, the functional capability and predictive assessment by CAE is the core technology. In a

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Sukarno, Ragil, I. Wayan Sugita, and Eko Arif Syaefudin. "PELATIHAN DASAR-DASAR CAD/CAM/CAE DAN SOFTWARE AUTOCAD UNTUK GURU-GURU SMK BIDANG KEAHLIAN TEKNIK MESIN DI WILAYAH KABUPATEN BEKASI." Sarwahita 11, no. 2 (2014): 122. http://dx.doi.org/10.21009/sarwahita.112.10.

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Di dunia industri, proses desain sebuah produk tidak lagi menggunakan cara-cara yang konvensional, akan tetapi menggunakan sebuah sarana komputer melalui sebuah software desain dan optimasi yang biasa disebut dengan istilah CAD/CAM/CAE. Namun, seiring dengan tantangan persaingan global yang sudah didepan mata, masih banyak guru-guru SMK terutama di wilayah Kecamatan Tarumajaya dan sekitarnya di Kabupaten Bekasi yang belum mumpuni dalam penguasaan teknologi informasi atau teknologi komputer di bidang desain dan analisa. Tujuan dari kegiatan pelatihan ini adalah untuk memberikan pengetahuan baru

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Brohus, Malene, Mads T. Søndergaard, Sui Rong Wayne Chen, Filip van Petegem, and Michael T. Overgaard. "Ca2+-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains." Biochemical Journal 476, no. 2 (2019): 193–209. http://dx.doi.org/10.1042/bcj20180545.

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Abstract The Ca2+ sensor calmodulin (CaM) regulates cardiac ryanodine receptor (RyR2)-mediated Ca2+ release from the sarcoplasmic reticulum. CaM inhibits RyR2 in a Ca2+-dependent manner and aberrant CaM-dependent inhibition results in life-threatening cardiac arrhythmias. However, the molecular details of the CaM–RyR2 interaction remain unclear. Four CaM-binding domains (CaMBD1a, -1b, -2, and -3) in RyR2 have been proposed. Here, we investigated the Ca2+-dependent interactions between CaM and these CaMBDs by monitoring changes in the fluorescence anisotropy of carboxytetramethylrhodamine (TAMR

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GAO, Sande, and Atsushi KATO. "3209 Research on CAD/CAE/CAM for a Die Cast." Proceedings of Design & Systems Conference 2007.17 (2007): 311–14. http://dx.doi.org/10.1299/jsmedsd.2007.17.311.

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Tran, Oanh, Silke Kerruth, Catherine Coates, et al. "Ca2+-Dependent and -Independent Calmodulin Binding to the Cytoplasmic Loop of Gap Junction Connexins." International Journal of Molecular Sciences 24, no. 4 (2023): 4153. http://dx.doi.org/10.3390/ijms24044153.

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Ca2+/calmodulin (Ca2+/CaM) interaction with connexins (Cx) is well-established; however, the mechanistic basis of regulation of gap junction function by Ca2+/CaM is not fully understood. Ca2+/CaM is predicted to bind to a domain in the C-terminal portion of the intracellular loop (CL2) in the vast majority of Cx isoforms and for a number of Cx-s this prediction has proved correct. In this study, we investigate and characterise both Ca2+/CaM and apo-CaM binding to selected representatives of each of the α, β and γ connexin family to develop a better mechanistic understanding of CaM effects on g

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Wang, Feng Jun. "Point-Based CAD/CAM Geometric Model Design." Advanced Materials Research 690-693 (May 2013): 2757–61. http://dx.doi.org/10.4028/www.scientific.net/amr.690-693.2757.

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At present, CAD/CAM technology is applied in many areas, and machinery manufacturing was one of these areas in which CAD/CAM technology is the first and most widely used. With the development of CAD/CAM technology, CAD/CAM technology has become a key technology to improve the design and manufacturing standards, and enhance the competitiveness of the industry. In this paper, the concept of point-based geometric models used in CAD/CAM is proposed, the definition of the point-based geometric model and its CAD/CAM application process are suggested, and the geometric characteristics of the point-ba

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Duret, Francois. "Dental CAD/CAM." Journal of the American Dental Association 123, no. 6 (1992): 11–12. http://dx.doi.org/10.14219/jada.archive.1992.0197.

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Isenberg, Barry P. "CAD-CAM Comments." Journal of the American Dental Association 124, no. 5 (1993): 14. http://dx.doi.org/10.14219/jada.archive.1993.0115.

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Mahmud, A., and P. Patel. "Let's CAD/CAM." British Dental Journal 228, no. 2 (2020): 59. http://dx.doi.org/10.1038/s41415-020-1212-8.

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Ghosh, S. K. "CAD/CAM dictionary." Journal of Mechanical Working Technology 18, no. 3 (1989): 354. http://dx.doi.org/10.1016/0378-3804(89)90094-6.

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World Dental Federation, FDI. "CAD/CAM Dentistry." International Dental Journal 68, no. 1 (2018): 18–19. http://dx.doi.org/10.1111/idj.12373.

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Arnetzl, G., and G. V. Arnetzl. "CAD/CAM-Systeme." Stomatologie 110, no. 3 (2013): 10–18. http://dx.doi.org/10.1007/s00715-013-0229-x.

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Kameyama, Masaki, Etsuko Minobe, Dongxue Shao, Jianjun Xu, Qinghua Gao, and Liying Hao. "Regulation of Cardiac Cav1.2 Channels by Calmodulin." International Journal of Molecular Sciences 24, no. 7 (2023): 6409. http://dx.doi.org/10.3390/ijms24076409.

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Cav1.2 Ca2+ channels, a type of voltage-gated L-type Ca2+ channel, are ubiquitously expressed, and the predominant Ca2+ channel type, in working cardiac myocytes. Cav1.2 channels are regulated by the direct interactions with calmodulin (CaM), a Ca2+-binding protein that causes Ca2+-dependent facilitation (CDF) and inactivation (CDI). Ca2+-free CaM (apoCaM) also contributes to the regulation of Cav1.2 channels. Furthermore, CaM indirectly affects channel activity by activating CaM-dependent enzymes, such as CaM-dependent protein kinase II and calcineurin (a CaM-dependent protein phosphatase). I

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Gamper, Nikita, and Mark S. Shapiro. "Calmodulin Mediates Ca2+-dependent Modulation of M-type K+ Channels." Journal of General Physiology 122, no. 1 (2003): 17–31. http://dx.doi.org/10.1085/jgp.200208783.

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To quantify the modulation of KCNQ2/3 current by [Ca2+]i and to test if calmodulin (CaM) mediates this action, simultaneous whole-cell recording and Ca2+ imaging was performed on CHO cells expressing KCNQ2/3 channels, either alone, or together with wild-type (wt) CaM, or dominant-negative (DN) CaM. We varied [Ca2+]i from &lt;10 to &gt;400 nM with ionomycin (5 μM) added to either a 2 mM Ca2+, or EGTA-buffered Ca2+-free, solution. Coexpression of wt CaM made KCNQ2/3 currents highly sensitive to [Ca2+]i (IC50 70 ± 20 nM, max inhibition 73%, n = 10). However, coexpression of DN CaM rendere

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Xu, Jian-Jun, Li-Ying Hao, Asako Kameyama, and Masaki Kameyama. "Calmodulin reverses rundown of L-type Ca2+ channels in guinea pig ventricular myocytes." American Journal of Physiology-Cell Physiology 287, no. 6 (2004): C1717—C1724. http://dx.doi.org/10.1152/ajpcell.00105.2004.

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Calmodulin (CaM) is implicated in regulation of Ca2+ channels as a Ca2+ sensor. The effect of CaM on rundown of L-type Ca2+ channels in inside-out patch form was investigated in guinea pig ventricular myocytes. Ca2+ channel activity disappeared within 1–3 min and did not reappear when the patch was excised and exposed to an artificial intracellular solution. However, application of CaM (0.03, 0.3, 3 μM) + 3 mM ATP to the intracellular solution within 1 min after patch excision resulted in dose-dependent activation of channel activity. Channel activity averaged 11.2%, 94.7%, and 292.9%, respect

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Ge, Qing, Yin Wang, and Ji Jun Ding. "Research of the CAD/CAM Technology Applications in Product Model-Making." Applied Mechanics and Materials 37-38 (November 2010): 972–75. http://dx.doi.org/10.4028/www.scientific.net/amm.37-38.972.

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With the flourish of the industrial design, the product model-making has become a professional sector. Based on the CAD/CAM technology, product model-making is vigorous flourishing. CAD/CAM technology consists of computer-aided design and computer aid manufacture. The paper presents an analysis on CAD/CAM Technology Application in forklift product model-making, where the product model-making for the CAD/CAM manufacture includes modeling CAD/CAM technology in the product data model and CAD/CAM integration NC programming system in the product model NC machining applications.

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"CAD/CAM/ CAE bugs." Smart Materials Bulletin 2002, no. 7 (2002): 3. http://dx.doi.org/10.1016/s1471-3918(02)00705-0.

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Thines, Louise, Hyunbum Jang, Zhigang Li, et al. "Disruption of Ca²⁺/calmodulin:KSR1 interaction lowers ERK activation." Protein Science 33, no. 5 (2024). http://dx.doi.org/10.1002/pro.4982.

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AbstractKSR1, a key scaffold protein for the MAPK pathway, facilitates ERK activation upon growth factor stimulation. We recently demonstrated that KSR1 binds the Ca2+‐binding protein calmodulin (CaM), thereby providing an intersection between KSR1‐mediated and Ca2+ signaling. In this study, we set out to generate a KSR1 point mutant with reduced Ca2+/CaM binding in order to unravel the functional implications of their interaction. To do so, we solved the structural determinants of complex formation. Using purified fragments of KSR1, we showed that Ca2+/CaM binds to the CA3 domain of KSR1. We

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"CAD/CAM/CAE [Product News]." IEEE Computational Science and Engineering 2, no. 3 (1995): 82. http://dx.doi.org/10.1109/mcse.1995.414898.

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"CAD/CAM/CAE and PDM software." Materials & Design 17, no. 4 (1996): 227–28. http://dx.doi.org/10.1016/s0261-3069(97)88940-6.

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"Distributed CAE and CAD/CAM systems." Advances in Engineering Software (1978) 7, no. 1 (1985): 51. http://dx.doi.org/10.1016/0141-1195(85)90110-x.

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Μenges, G. "CAE/CAD/CAM in Plastics Processing." Journal of Polymer Engineering 6, no. 1-4 (1986). http://dx.doi.org/10.1515/polyeng.1986.6.1-4.1.

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"CAE/CAD/CAM-Software auf neuen Arbeitsplatzrechnern." Zeitschrift für wirtschaftlichen Fabrikbetrieb 83, no. 1 (1988): 45. http://dx.doi.org/10.1515/zwf-1988-830123.

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Afify, Mohammed, Younes Moubachir, Zouhair Guennoun, and Jamila Hassar. "A hybrid CAD/CAE/CAM project‐based laboratory framework integrating topology optimization and laser powder bed fusion for engineering education." Computer Applications in Engineering Education, April 9, 2024. http://dx.doi.org/10.1002/cae.22745.

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AbstractIn the era of Industry 4.0, laser‐based additive manufacturing (LBAM) has gained substantial momentum in the production of complex lightweight structures in several domains such as aerospace, civil, and biomedical engineering. The increasing demand for consistent and precise manufacturing processes has urged the manufacturing industry to consider the coupling of topology optimization (TO) and laser powder bed fusion (LPBF) in the design of sophisticatedly novel topologies that are unattainable through traditional processes. Notably, this union has demonstrated a highly efficient and pr

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Kirkwood, Robert, and James A. Sherwood. "Sustained Integration for Computer-Aided Manufacturing: Integrating With Successive Versions of Step or IGES Files." Journal of Computing and Information Science in Engineering 18, no. 4 (2018). http://dx.doi.org/10.1115/1.4040024.

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Computer-aided design (CAD)/computer-aided manufacturing (CAM)/computer-aided engineering (CAE) integration offers designers, analysts, and manufacturers the opportunity to share data efficiently throughout the product development process. CAM for NC programing and tool design integrated with solid model data from CAD systems represents a large portion of the CAD/CAM/CAE domain. Sustained integration whereby successive changes to a CAD model are reintegrated with downstream applications is considered the most advanced and useful integration. Sustained integration is typically maintained when w

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