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Dissertations / Theses on the topic 'CAMP/cGMP'

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Published: 4 June 2021

Last updated: 9 February 2022

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1

Schobesberger, Sophie. "Changes in cardiomyocyte structure and cAMP/cGMP signalling during heart failure." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/34341.

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The contractile function of the heart depends on efficient β adrenergic receptor (βAR) signalling which involves cycling nucleotides as second messengers. Correct secondary messenger signalling is only possible in healthy, well structured cardiac myocytes. Of the three βAR subtypes present in human cardiomyocytes β1AR and β2AR classically signal via 3'-5' cyclic adenosine monophosphate (cAMP) to regulate contraction after catecholamine administration, whereby the second isoform may also be cardioprotective. The far less characterised β3AR has been controversially associated to both increasing

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2

Assender, Jean W. "Control of vascular smooth muscle cell proliferation by cyclic nucleotides." Thesis, Cardiff University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389966.

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3

Janßen, Julia Annika. "In vivo FLIM-FRET as a novel technique to assess cAMP and cGMP in the intact zebrafish heart." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-232452.

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Introduction: 23 million patients worldwide suffer from heart failure. These patients depend on cardiac research, because cardiac research enables the development of new therapeutic strategies and –targets. In cardiomyocytes, the compartmentalization of cAMP and cGMP depends on many factors. T-tubuli and PDEs are responsible for the division of cells in microdomains in which localized and specific cAMP and cGMP-signaling occurs. The aim of this thesis was to develop a method to answer the open questions that remain about the physiological and pathophysiological significance of cAMP/cGMP compar

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4

Kühn, Rainer. "Untersuchungen zur Bedeutung der cAMP- und cGMP- abhängigen Signaltransduktion in der Kontrolle der glatten Muskulatur des humanen Ureters." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-84072.

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5

Karlisch, Kaja [Verfasser], and Andreas [Gutachter] Friebe. "Die Rolle der PDE3 im cGMP/cAMP-Crosstalk in NO-GC-defizienten Mäusen / Kaja Karlisch. Gutachter: Andreas Friebe." Würzburg : Universität Würzburg, 2013. http://d-nb.info/1102826138/34.

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6

Kühn, Rainer. "Untersuchungen zur Bedeutung der cAMP- und cGMP- abhängigen Signaltransduktion in der Kontrolle der glatten Muskulatur des humanen Ureters : Eine funktionelle Studie." kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/8407/.

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7

Dünnes, Sarah [Verfasser], Andreas [Gutachter] Friebe, and Erhard [Gutachter] Wischmeyer. "Einfluss der NO-sensitiven Guanylyl-Cyclase auf den cGMP/cAMP-Crosstalk und die Steifigkeit der murinen Aorta / Sarah Dünnes ; Gutachter: Andreas Friebe, Erhard Wischmeyer." Würzburg : Universität Würzburg, 2016. http://d-nb.info/1121508316/34.

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8

Marais, Erna. "Role of cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP) and p38 mitogen activated protein kinase (p38 MAPK) in preconditioning of the ischaemic myocardium." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/53039.

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Thesis (PhD)--University of Stellenbosch, 2002.<br>ENGLISH ABSTRACT: Ischaemic preconditioning (PC) is the phenomenon whereby a short episode of coronary occlusion followed by reperfusion protects the myocardium against a subsequent period of prolonged (also called index or sustained) ischaemia. Even though the exact mechanism of PC remains to be established, it implies that the heart has an endogenous protective mechanism against ischaemia which, if identified, may have important clinical implications. The importance of establishing the mechanism of PC lies in the potential to convert

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9

Dünnes, Sarah Verfasser], Andreas [Gutachter] [Friebe, and Erhard [Gutachter] Wischmeyer. "Einfluss der NO-sensitiven Guanylyl-Cyclase auf den cGMP/cAMP-Crosstalk und die Steifigkeit der murinen Aorta / Sarah Dünnes ; Gutachter: Andreas Friebe, Erhard Wischmeyer." Würzburg : Universität Würzburg, 2016. http://d-nb.info/1121508316/34.

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10

MARTINS, Daniella Ramos. "Avaliação do relaxamento vascular induzido por um novo derivado pirazólico protótipo a fármaco (LQFM 021), possível inibidor de fosfodiesterase." Universidade Federal de Goiás, 2012. http://repositorio.bc.ufg.br/tede/handle/tde/2110.

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Made available in DSpace on 2014-07-29T16:11:50Z (GMT). No. of bitstreams: 1 Dissertacao DAniella Ramos Martins.pdf: 914272 bytes, checksum: 038f97a7fcd95721aab346f4a3bd0587 (MD5) Previous issue date: 2012-02-28<br>The inhibition of phosphodiesterases (PDEs) increases intracellular levels of cyclic nucleotides 3 ': 5'-cyclic adenosine monophosphate (cAMP) and 3 ': 5'-cyclic guanosine monophosphate (cGMP), which has many physiological and biochemical effects, especially in cardiovascular system. The objective of this study was to analyze the pharmacological effects of a new compound derived f

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11

Zaffalon, Fabiane Gilli. "Influência de diferentes isoformas de fosfodiesterases no controle da maturação de oócitos bovinos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/74/74131/tde-29012015-091454/.

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A maturação in vitro do oócito é um dos fatores limitantes na produção in vitro de embriões. In vivo, esta maturação é um processo altamente orquestrado no qual a meiose é retomada pela onda de gonadotrofina que antecede a ovulação e que induz à queda dos níveis de AMPc no oócito. No entanto, os oócitos aspirados ao serem retirados dos folículos ovarianos retomam espontaneamente a maturação comprometendo a competência de seu desenvolvimento. O AMPc é sintetizado pela adenilato ciclase (AC) e degradado pelas fosfodiesterases (PDE), existindo algumas relacionadas à degradação do AMPc e outras do

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12

Lindner, Marta. "L'activation de la phosphodiestérase de type 2 pour traiter l'insuffisance cardiaque." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS336/document.

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L’AMP cyclique (AMPc) et le GMP cyclique (GMPc) sont des seconds messagers essentiels pour la régulation de la fonction cardiaque. La concentration de l’AMPc intracellulaire est régulée par les activités d'au moins deux familles d'enzymes: les cyclases et guanylyl cyclases, responsable de la synthèse de l'AMPc et du GMPc, et les phosphodiestérases (PDE) qui interviennent dans l’hydrolyse de l'AMPc et du GMPc.Parmi la superfamille des PDEs, la PDE2 est une enzyme à double substrat qui hydrolyse à la fois l'AMPc et le GMPc et a la propriété unique d'être stimulée par le GMPc. Il a été récemment

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13

Götz, Konrad [Verfasser], Viacheslav [Akademischer Betreuer] Nikolaev, Michael P. [Akademischer Betreuer] Schön, and Peter [Akademischer Betreuer] Rehling. "Real time visualization of cGMP and cAMP dynamics in intact adult cardiomyocytes using new transgenic mice / Konrad Götz. Gutachter: Michael P. Schön ; Peter Rehling. Betreuer: Viacheslav Nikolaev." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2015. http://d-nb.info/1065882440/34.

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14

Mehel, Hind. "Rôle et régulation de la phosphodiestérase de type 2 dans l’insuffisance cardiaque." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA114831/document.

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L'AMP cyclique (AMPc) et le GMP cyclique (GMPc) sont des seconds messagers essentiels pour la régulation de la fonction cardiaque. Leurs niveaux sont régulés par l’adénylate cyclase et la guanylate cyclase, respectivement, et par les phosphodiestérases (PDEs). Cependant, une telle régulation est altérée dans l'insuffisance cardiaque (IC). En effet, la diminution de la signalisation de l’AMPc et l’augmentation de celle du GMPc est caractéristique des cœurs défaillants.Parmi la superfamille des PDEs, la PDE2 a la particularité d'être stimulée par le GMPc, conduisant ainsi à une augmentation rema

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15

Öckl, Patrick [Verfasser]. "Establishment of mass spectrometric determination of the biomarkers cAMP and cGMP and investigation of potential pathogenic processes (GPR6, telomerase, microglial activation) in animal models of Parkinson´s disease / Patrick Öckl." Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1038734835/34.

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16

Zhang, Liang. "Évaluation du rôle de nouvelles isoformes de PDE dans la compartimentation des nucléotides cycliques dans les cellules musculaires lisses vasculaires et les cardiomyocytes." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS290.

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Les deux nucléotides cycliques, AMPc et GMPc, sont des seconds messagers importants qui régulent une grande variété de fonctions cellulaires, en particulier la fonction contractile cardiovasculaire, la croissance des cardiomyocytaires et la prolifération des cellules musculaires lisses vasculaires. Les phosphodiestérases (PDE) dégradent les nucléotides cycliques et exercent un contrôle local de leur concentration intracellulaire. Une altération de la voie de signalisation des nucléotides cycliques est impliquée dans plusieurs situations pathologiques telles que l’hypertension artérielle systém

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17

Janßen, Julia Annika [Verfasser], Ali [Akademischer Betreuer] El-Armouche, Christopher [Akademischer Betreuer] Antos, Henning [Gutachter] Morawietz, and Ali [Gutachter] El-Armouche. "In vivo FLIM-FRET as a novel technique to assess cAMP and cGMP in the intact zebrafish heart / Julia Annika Janßen ; Gutachter: Henning Morawietz, Ali El-Armouche ; Ali El-Armouche, Christopher Antos." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://d-nb.info/1151816477/34.

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18

Pires, Pedro Ratto Lisboa. "Influência do hormônio folículo estimulante na via da óxido nítrico sintase em complexos cumulus-oócitos bovinos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/74/74131/tde-21022011-112344/.

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O óxido nítrico (NO) é um mensageiro químico gerado pela atividade da enzima óxido nítrico sintase (NOS) a qual foi detectada em vários órgãos incluídos os do sistema reprodutor e parece estar envolvido na maturação oocitária. No entanto, há poucos estudos sobre o papel desse sistema em oócitos da espécie bovina. Sabe-se que o NO atua pela via da guanilato ciclase (GC) estimulando a produção do nucleotídeo GMPc, que por sua vez é capaz de influenciar nos níveis de outro nucleotídeo (AMPc) via fosfodiesterases (PDE). O AMPc é um importante elemento da via de sinalização do FSH nos complexos cum

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19

Gasser, Carlos Fernando. "Konstruktion und Charakterisierung einer lichtaktivierten Phosphodiesterase." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17374.

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Genetisch kodierte Photorezeptoren in Modellorganismen begründen die Optogenetik. Sie ermöglicht die nicht-invasive, reversible und räumlich-zeitlich präzise Perturbation von zellulären und physiologischen Signalprozessen durch Licht. Natürliche photoaktivierte Adenylylzyklasen (PACs) steigern die intrazelluläre Konzentration des Botenstoffs zyklischen Adenosinmonophosphats (cAMP) durch Blaulicht. Damit erlauben sie die optogenetische Analyse von cAMP-abhängigen Signalwegen. Diese Arbeit komplementiert PACs durch die synthetische rotlichtaktivierte Phosphodiesterase LAPD zur Degradation von cA

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20

Nikolaev, Viacheslav. "Development and application of fluorescent cAMP und cGMP biosensors." Doctoral thesis, 2005. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-15673.

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The cyclic nucleotides cAMP and cGMP are two ubiquitous important second messengers, which regulate diverse physiological responses from vision and memory to blood pressure and thrombus formation. They act in cells via cAMP- and cGMP-dependent protein kinases (PKA and GK), cyclic nucleotide-gated channels and Epac. Although the concept of cyclic nucleotide signalling is well developed based on classical biochemical studies, these techniques have not allowed to analyze cAMP and cGMP in live cells with high temporal and spatial resolution. In the present study fluorescence resonance energy trans

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21

Nikolaev, Viacheslav [Verfasser]. "Entwicklung und Anwendung fluoreszierender Biosensoren für cAMP und cGMP / vorgelegt von Viacheslav Nikolaev." 2006. http://d-nb.info/981594832/34.

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22

Karlisch, Kaja. "Die Rolle der PDE3 im cGMP/cAMP-Crosstalk in NO-GC-defizienten Mäusen." Doctoral thesis, 2013. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-98857.

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Die NO-sensitive Guanylyl-Cyclase (NO-GC) ist der wichtigste Rezeptor für das freigesetzte Signalmolekül NO und katalysiert die Bildung des second Messenger cGMP. Die NO/cGMP Signalkaskade ist im kardiovaskulären System essentiell für die Hemmung der Thrombozytenaggregation und des Tonus der glatten Gefäßmuskulatur und trägt damit zur Regulation des Blutdrucks bei. In der Arbeitsgruppe wurden Mauslinien generiert, bei denen die NO-GC ubiquitär (GCKO) oder spezifisch in glatten Muskelzellen (SM-GCKO) ausgeschaltet ist. Beide Mausstämme zeigen eine arterielle Hypertonie mit einem Anstieg des sys

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23

WILSON, LINDSAY SHEA. "INTEGRATING PHOSPHOLIPID AND CYCLIC NUCLEOTIDE SIGNALING: ROLES OF PHOSPHODIESTERASES AS ENZYMES AND TETHERS." Thesis, 2011. http://hdl.handle.net/1974/6581.

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Cells of the cardiovascular system translate incoming extracellular signals from hormones and drugs through binding of cell surface receptors, and activation of intracellular signaling cascades allowing modulation of specific cellular function. cAMP and cGMP are ubiquitous second messengers that activate specific signaling machinery used to promote or inhibit cellular functions such as cell migration, cell adhesion and proliferation. Increases in intracellular cAMP or cGMP levels occurs through activation of adenylyl cyclase (cAMP) or guanylyl cyclase (cGMP) or by inhibition of the cAMP and cG

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24

Götz, Konrad. "Real time visualization of cGMP and cAMP dynamics in intact adult cardiomyocytes using new transgenic mice." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0022-5D96-7.

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25

Herrera, Natalia M. "Physiological and Molecular Effects of the Cyclic Nucleotides cAMP and cGMP on Arabidopsis thaliana." Thesis, 2012. http://hdl.handle.net/10754/255082.

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The cyclic nucleotide monophosphates (CNs), cAMP and cGMP, are second messengers that participate in the regulation of development, metabolism and adaptive responses. In plants, CNs are associated with the control of pathogen responses, pollen tube orientation, abiotic stress response, membrane transport regulation, stomatal movement and light perception. In this study, we hypothesize that cAMP and cGMP promote changes in the transcription level of genes related to photosynthesis, high light and membrane transport in Arabidopsis thaliana leaves and, that these changes at the molecular level ca

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26

Fischer, Anna. "Die Regulation aktivierender und hemmender Signalwege in humanen neutrophilen Granulozyten durch cAMP- und cGMP-erhöhende Vasodilatatoren." Doctoral thesis, 2004. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-13331.

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Neutrophile Granulozyten sind wichtige Effektorzellen des menschlichen Immunsystems. Eine Suppression der Neutrophilen kann zur Immundeffizienz mit Gefahr für bakterielle Erkrankungen und maligne Tumoren führen, eine Überstimulation dieser Zellen ist jedoch an der Entstehung der Autoimmunerkrankungen beteiligt. Im Rahmen dieser Arbeit wurden aktivierende und hemmende Wege untersucht, die für zukünftige Strategien in Prävention und Therapie dieser Erkrankungen eine wichtige Rolle spielen. Neutrophile Granulozyten enthalten VASP in hoher Konzentration. VASP ist ein bereits gut charakterisiertes

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27

陳奕中. "Pharmacological study of theophylline-based berivatives:involvement K+ channels and cAMP/cGMP enhancing activities in smooth muscle." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/14053100672862101734.

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28

Lämmle, Simon. "Die Rolle der Phosphodiesterase 2 im Herzen." Doctoral thesis, 2014. http://hdl.handle.net/11858/00-1735-0000-0023-994E-0.

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Herzinsuffizienz ist ein weltweites Gesundheitsproblem mit hoher Morbidität und Mortalität und immer noch schlechter Prognose. Ein charakteristisches Merkmal der molekularen und damit verbundenen strukturellen Veränderungen, die der terminalen Insuffizienz vorangehen ist die durch Desensitivierungsmechanismen vermittelte Abnahme des beta-adrenergen (β-AR) Signalmoleküls zyklisches Adenosinmonophosphat (cAMP) auf der einen Seite und der gleichzeitigen Zunahme des von natriuretischen Peptiden (NP) und Stickstoffmonoxid (NO) generierten zyklischen Guanosinmonophosphat (cGMP) auf der anderen Seite

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29

Bruder, Sandra [Verfasser]. "cAMP- und cGMP-bindende Tandem-GAF-Domänen : biochemische Untersuchungen mit einer cyanobakteriellen Adenylatcyclase / vorgelegt von Sandra Bruder." 2006. http://d-nb.info/978483103/34.

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30

Dünnes, Sarah. "Einfluss der NO-sensitiven Guanylyl-Cyclase auf den cGMP/cAMP-Crosstalk und die Steifigkeit der murinen Aorta." Doctoral thesis, 2016. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-141479.

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Die NO/cGMP-vermittelte Signalkaskade ist im vaskulären System entscheidend an der Regulation des Blutdrucks beteiligt. Innerhalb der Kaskade nimmt die NO-sensitive Guanylyl-Cyclase (NO-GC) eine Schlüsselfunktion als wichtigster Rezeptor für das Signalmolekül Stickstoffmonoxids (NO) ein. NO wird endogen von verschiedenen Isoformen der NO Synthase produziert. Die Bindung von NO an die NO GC führt zur Produktion des sekundären Botenstoffs cyclisches Guanosinmonophosphat (cGMP). Dieser Botenstoff aktiviert verschiedene Effektor-Moleküle und bewirkt letztlich eine Relaxation der glatten Muskulatur

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31

Janßen, Julia Annika. "In vivo FLIM-FRET as a novel technique to assess cAMP and cGMP in the intact zebrafish heart." Doctoral thesis, 2017. https://tud.qucosa.de/id/qucosa%3A30747.

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Introduction: 23 million patients worldwide suffer from heart failure. These patients depend on cardiac research, because cardiac research enables the development of new therapeutic strategies and –targets. In cardiomyocytes, the compartmentalization of cAMP and cGMP depends on many factors. T-tubuli and PDEs are responsible for the division of cells in microdomains in which localized and specific cAMP and cGMP-signaling occurs. The aim of this thesis was to develop a method to answer the open questions that remain about the physiological and pathophysiological significance of cAMP/cGMP compar

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32

Wilczek, Manuela [Verfasser]. "Paramecium biaurelia im niederfrequenten Magnetfeld : Auswirkungen auf das Schwimmverhalten, die cAMP-, cGMP- und 5-̀Methoxytryptamin-Konzentrationen / vorgelegt von Manuela Wilczek." 2001. http://d-nb.info/967655323/34.

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33

Fischer, Anna [Verfasser]. "Die Regulation aktivierender und hemmender Signalwege in humanen neutrophilen Granulozyten durch cAMP- und cGMP-erhöhende Vasodilatatoren / vorgelegt von Anna Fischer." 2005. http://d-nb.info/97518556X/34.

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34

Kühn, Rainer [Verfasser]. "Untersuchungen zur Bedeutung der cAMP- und cGMP-abhängigen Signaltransduktion in der Kontrolle der glatten Muskulatur des humanen Ureters : eine funktionelle Studie / vorgelegt von Rainer Kühn." 2008. http://d-nb.info/988921553/34.

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35

Wong, Aloysius Tze. "Nitric Oxide Binds to and Modulates the Activity of a Pollen Specific Arabidopsis Diacylglycerol Kinase." Diss., 2014. http://hdl.handle.net/10754/320295.

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Nitric oxide (NO) is an important signaling molecule in plants. In the pollen of Arabidopsis thaliana, NO causes re-orientation of the growing tube and this response is mediated by 3′,5′-cyclic guanosine monophosphate (cGMP). However, in plants, NO-sensors have remained somewhat elusive. Here, the findings of an NO-binding candidate, Arabidopsis thaliana DIACYLGLYCEROL KINASE 4 (ATDGK4; AT5G57690) is presented. In addition to the annotated diacylglycerol kinase domain, this molecule also harbors a predicted heme-NO/oxygen (H-NOX) binding site and a guanylyl cyclase (GC) catalytic domain which

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36

"Hyperglycemic impairment of CGRP-induced cAMP responses in vascular smooth muscle cells (VSMCs) and the role of cGMP/protein kinase G pathway in regulating apoptosis and proliferation of VSMCs and bone marrow stromal stem cells." 2006. http://library.cuhk.edu.hk/record=b5893055.

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Wong Cheuk Ying.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2006.<br>Includes bibliographical references (leaves 101-124).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>摘要 --- p.iv<br>Acknowledgement --- p.vi<br>List of Abbreviations --- p.vii<br>Chapter Chapter 1. --- General Introduction --- p.1<br>Chapter Chapter 2. --- Methods --- p.4<br>Chapter 2.1 --- Measurement of cAMP and cGMP in VSMCs --- p.4<br>Chapter 2.1.1 --- Cell culture --- p.4<br>Chapter 2.1.2 --- Enzyme-immunoassay colorimetric measurement for cAMP and cGMP --- p.5<br>Chapter 2.1.3 --- Statis

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