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Journal articles on the topic 'Cancellous bone defects'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

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1

Dorea, H. C., H. D. Cantwell, R. Read, L. Armbrust, R. Pool, J. K. Roush, C. Boyle, and R. M. McLaughlin. "Evaluation of healing in feline femoral defects filled with cancellous autograft, cancellous allograft or Bioglass." Veterinary and Comparative Orthopaedics and Traumatology 18, no. 03 (July 2005): 157–68. http://dx.doi.org/10.1055/s-0038-1632947.

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SummaryCancellous bone grafting is a widely accepted technique in human and veterinary orthopaedic surgery. However, the use of autogenous bone graft is limited by the additional surgical time required to harvest the graft, the morbidity associated with the donor site, and the limited availability of cancellous bone, especially in feline patients. Various allografts and bone graft substitutes are available commercially but have not been fully evaluated for efficacy in the cat. The purpose of this study was to compare the incorporation of autogenous and allogenous cancellous bone graft and Biog

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Díaz-Bertrana, C., P. Lafuente, P. Fontecha, I. Durall, and J. Franch. "Beta-tricalcium phosphate as a synthetic cancellous bone graft in veterinary orthopaedics." Veterinary and Comparative Orthopaedics and Traumatology 19, no. 04 (October 2006): 196–204. http://dx.doi.org/10.1055/s-0038-1633001.

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SummaryThe clinical use of β-tricalcium phosphate (β-TCP) as a synthetic cancellous bone graft in veterinary orthopaedics is herein reported. The retrospective study was based on 13 clinical cases belonging to 11 dogs and one cat. The weights of the dogs ranged from 3.4 to 48 kg. One female cat weighing 3.5 kg completed the study. The clinical cases were six arthrodeses (four carpal, two tarsal), one hypertrophic non-union (femur), one atrophic non-union (metacarpal bones) and five long-bone fractures (two femurs, one tibia, two radii) possessing subcritical-sized bone defects. The β-TCP used

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Verboket, René D., Tanja Irrle, Yannic Busche, Alexander Schaible, Katrin Schröder, Jan C. Brune, Ingo Marzi, Christoph Nau, and Dirk Henrich. "Fibrous Demineralized Bone Matrix (DBM) Improves Bone Marrow Mononuclear Cell (BMC)-Supported Bone Healing in Large Femoral Bone Defects in Rats." Cells 10, no. 5 (May 19, 2021): 1249. http://dx.doi.org/10.3390/cells10051249.

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Regeneration of large bone defects is a major objective in trauma surgery. Bone marrow mononuclear cell (BMC)-supported bone healing was shown to be efficient after immobilization on a scaffold. We hypothesized that fibrous demineralized bone matrix (DBM) in various forms with BMCs is superior to granular DBM. A total of 65 male SD rats were assigned to five treatment groups: syngenic cancellous bone (SCB), fibrous demineralized bone matrix (f-DBM), fibrous demineralized bone matrix densely packed (f-DBM 120%), DBM granules (GDBM) and DBM granules 5% calcium phosphate (GDBM5%Ca2+). BMCs from d

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Schneppendahl, J., T. T. Lögters, M. Sager, M. Wild, M. Hakimi, J. Windolf, J. P. Grassmann, and P. Jungbluth. "Treatment of a diaphyseal long-bone defect with autologous bone grafts and platelet-rich plasma in a rabbit model." Veterinary and Comparative Orthopaedics and Traumatology 28, no. 03 (2015): 164–71. http://dx.doi.org/10.3415/vcot-14-05-0079.

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Summary Introduction: Large bone defects are a therapeutic challenge to surgeons and are often associated with a high morbidity. The use of autologous cancellous bone graft represents an essential therapeutic option and is considered the gold standard. However, the use of platelet-rich plasma (PRP) for improving bone defect healing has been discussed controversially. The aim of this study was to evaluate the treatment of a diaphyseal long-bone defect in a rabbit model with a combination of PRP and autologous cancellous bone. Material and methods: A monocortical long-bone defect in the radial d

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5

Zheng, Chong, Hai-yang Ma, Yin-qiao Du, Jing-yang Sun, Ji-wei Luo, Dong-bin Qu, and Yong-gang Zhou. "Finite Element Assessment of the Screw and Cement Technique in Total Knee Arthroplasty." BioMed Research International 2020 (October 15, 2020): 1–7. http://dx.doi.org/10.1155/2020/3718705.

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Background. The screw and cement technique is a convenient method used to rebuild medial tibial plateau defects in primary total knee arthroplasty (TKA). The objective of this study was to perform a finite element assessment to determine the effect of different numbers of screws on the stability of TKA and to determine whether differences exist between two different insertion angles. Method. Six tibial finite element models with defects filled with screws and cement and one model with defects filled only with cement were generated. Contact stresses on the surface of cancellous bone in differen

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Murata, Koichi, Shunsuke Fujibayashi, Bungo Otsuki, Takayoshi Shimizu, and Shuichi Matsuda. "Repair of Iliac Crest Defects with a Hydroxyapatite/Collagen Composite." Asian Spine Journal 14, no. 6 (December 31, 2020): 808–13. http://dx.doi.org/10.31616/asj.2019.0310.

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Study Design: Retrospective study.Purpose: This study aimed to assess the effect of refilling with hydroxyapatite/collagen (HAp/Col) composite on an iliac crest defect after spinal fusion.Overview of Literature: The use of iliac crest bone graft has been the gold standard in spinal fusion for a long time because of its biological and non-immunologic properties. Few reports have addressed how bone defects recover after iliac crest bone harvest following spinal fusion.Methods: Cancellous bone was collected from the anterior iliac crest during lateral interbody fusion (LIF), and the bone void of

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Dogan, E., and Z. Okumus. "Cuttlebone used as a bone xenograft in bone healing." Veterinární Medicína 59, No. 5 (July 15, 2014): 254–60. http://dx.doi.org/10.17221/7519-vetmed.

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This study was conducted to examine the potential of cuttlebone xenograft in the healing of bone using radiography and histology for a period of 24 weeks. One hundred and five New Zealand male rabbits with radius defects in the metaphyseal region were divided into five groups treated with cuttlebone, demineralized bone matrix, bovine cancellous graft, and tricalcium phosphate. The control was no treatment. Clinical, radiological, biochemical and histological evaluations were made 1, 2, 3, 4, 6, 12, and 24 weeks after surgery. Physiological measurements (body temperature, heart rate, and respir

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8

Borghetti, Alain, Giséle Novakovitch, Francis Louise, Didier Simeone, and Jean Fourel. "Cryopreserved Cancellous Bone Allograft in Periodontal Intraosseous Defects." Journal of Periodontology 64, no. 2 (February 1993): 128–32. http://dx.doi.org/10.1902/jop.1993.64.2.128.

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9

Singh, Luthra Jatinder, and Salim A. L. Habsi. "Biological Reconstruction of Varus Deformity in Primary Total Knee Replacement Using Bone Graft and Description of a New Technique." Journal of Orthopaedics, Trauma and Rehabilitation 25, no. 1 (June 1, 2018): 69–72. http://dx.doi.org/10.1016/j.jotr.2017.11.001.

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Peripheral bony defects of the tibia can be seen in patients with osteoarthritis of the knee. These defects must be corrected at the time of total knee replacement to ensure correct placement and alignment of the components. We describe a new technique for correcting large tibial defect by using bone graft, where the uncontained defects were converted to contained defects using bone graft and the contained defect was impacted with cancellous bone. Between 2006 and 2010, 48 cases of primary total knee arthroplasty were reconstructed using autologous bone graft. Of 48 cases, five cases had large

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10

Aspenberg, P., J. Wittbjer, and K. G. Thorngren. "Bone matrix and marrow versus cancellous bone in rabbit radial defects." Archives of Orthopaedic and Traumatic Surgery 106, no. 6 (October 1987): 335–40. http://dx.doi.org/10.1007/bf00456866.

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11

Xu, Guo Hua, Xiao Jian Ye, Wen Yuan, Shu Cai, Jian Gang Shi, and Jian Ru Xiao. "Repairing the Dog's Femoral Defect with the Autologous Osteoblast Integrated the Nano-Calcium Phosphate/Zirconia Scaffold." Key Engineering Materials 336-338 (April 2007): 1662–65. http://dx.doi.org/10.4028/www.scientific.net/kem.336-338.1662.

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In this paper, we study the effect of repairing the dog's femoral defects with the artificial bone integrating the nano-calcium phosphates/zirconia porous artificial bone scaffold with the autologous osteoblasts. We transplanted the artificial bone to the femoral defect of the dog, and at the same time, simple scaffold and the autologous cancellous bone were implanted as the control group. 3 months after the transplantation, the specimen was taken out with complete integration with the bone in these 3 groups and the bone defect got the complete bone union. The mechanics strength test showed th

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Shani, J., and U. Segal. "Surgical management of large segmental femoral and radial bone defects in a dog." Veterinary and Comparative Orthopaedics and Traumatology 23, no. 01 (2010): 66–70. http://dx.doi.org/10.3415/vcot-09-04-0047.

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SummaryIn this case report, we describe the use of a cylindrical titanium mesh cage combined with cancellous bone graft to surgically manage large segmental bone defects in a dog. A seven-year-old, neutered male cross-breed dog, with highly comminuted fractures of the right femur and the left radius and ulna, was referred for treatment. Previous open reduction and internal fixation of these fractures had failed. Following implant removal and debridement of each bone, a 71 mm segmental femoral defect and a 27 mm segmental radial defect were present. A commercially available cylindrical titanium

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Kanjilal, Deboleena, Christopher Grieg, Maya Deza Culbertson, Sheldon S. Lin, Michael Vives, Joseph Benevenia, and J. Patrick O’Connor. "Improved osteogenesis in rat femur segmental defects treated with human allograft and zinc adjuvants." Experimental Biology and Medicine 246, no. 16 (May 26, 2021): 1857–68. http://dx.doi.org/10.1177/15353702211019008.

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Bone allograft is widely used to treat large bone defects or complex fractures. However, processing methods can significantly compromise allograft osteogenic activity. Adjuvants that can restore the osteogenic activity of processed allograft should improve clinical outcomes. In this study, zinc was tested as an adjuvant to increase the osteogenic activity of human allograft in a Rag2 null rat femoral defect model. Femoral defects were treated with human demineralized bone matrix (DBM) mixed with carboxy methyl cellulose containing ZnCl2 (0, 75, 150, 300 µg) or Zn stearate (347 µg). Rat femur d

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Nečas, Alois, Pavel Proks, Lucie Urbanová, Robert Srnec, Ladislav Stehlík, Michal Crha, Petr Raušer, et al. "Healing of Large Segmental Bone Defect after Implantation of Autogenous Cancellous Bone Graft in Comparison to Hydroxyapatite and 0.5% Collagen Scaffold Combined with Mesenchymal Stem Cells." Acta Veterinaria Brno 79, no. 4 (2010): 607–12. http://dx.doi.org/10.2754/avb201079040607.

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At present, attention is focused on research into possibilities of healing large bone defects by the method of mini-invasive osteosynthesis, using implantation of biomaterials and mesenchymal stem cells (MSCs). This study evaluates the healing of segmental femoral defects in miniature pigs based on the radiological determination of the callus: cortex ratio at 16 weeks after ostectomy. The size of the formed callus was significantly larger (p < 0.05) in animals after transplantation of an autogenous cancellous bone graft (group A, callus : cortex ratio of 1.77 ± 0.33) compared to animals aft

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Heikkilä, Jouni T., Heikki J. Aho, Antti Yli-urpo, Risto-Pekka Happonen, and Allan J. Aho. "Bone formation in rabbit cancellous bone defects filled with bioactive glass granules." Acta Orthopaedica Scandinavica 66, no. 5 (January 1995): 463–67. http://dx.doi.org/10.3109/17453679508995588.

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16

Richter, M., F. Laurent, and J. M. Chausse. "Homologous cancellous bone grafts for large jaw defects caused by bone cysts." Journal of Oral and Maxillofacial Surgery 44, no. 6 (June 1986): 447–53. http://dx.doi.org/10.1016/s0278-2391(86)80009-x.

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17

Joo, Min Wook, Seung Jae Chung, Seung Han Shin, and Yang-Guk Chung. "The Effect of Autologous Platelet-Rich Plasma on Bone Regeneration by Autologous Mesenchymal Stem Cells Loaded onto Allogeneic Cancellous Bone Granules." Cells Tissues Organs 203, no. 6 (2017): 327–38. http://dx.doi.org/10.1159/000454915.

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To develop a clinically effective bone regeneration strategy, we compared bone regeneration using allogeneic cancellous bone granule scaffolds loaded with autologous bone marrow-derived mesenchymal stem cells (BM-MSC) with or without autologous platelet-rich plasma (PRP). Critical-sized segmental bone defects were made at the mid-shaft of both radiuses in 41 New Zealand White rabbits. Small-sized allogeneic cancellous bone granules (300-700 μm in diameter) loaded with BM-MSC were implanted on one side, and PRP was added. On the other side, autologous BM-MSC loaded onto allogeneic cancellous gr

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18

McLaughlin, R., J. Hoskinson, and Dominique Griffon. "Effects of a Bone Inducing Agent Derived from a Cultured Human Osteosarcoma Cell Line after Orthotopic and Heterotopic Implantation in the Dog." Veterinary and Comparative Orthopaedics and Traumatology 09, no. 01 (1996): 22–8. http://dx.doi.org/10.1055/s-0038-1632497.

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SummaryBIA, a Bone Inducing Agent extracted from a cultured human osteosarcoma cell line (Saos–2), is highly osteoinductive in the skeletal muscle of athymic mice and promotes early osseous union of stabilized femoral non-unions in rats. To evaluate its effect in dogs, ten milligrams of BIA mixed with an equal amount of pure bovine collagen type I was compared with 20 mg of bovine collagen alone, a gelatin capsule alone, and fresh autogenous cancellous graft, after orthotopic and heterotopic implantation in Beagles.For osteoinductive bioassays, each implant was placed in the latissimus dorsi m

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19

Srnec, Robert, Andrea Nečasová, Pavel Proks, Miša Škorič, Zita Filipejová, Lucy Vojtová, and Alois Nečas. "Femoral bone defect healing using two novel biocompatible degradable materials." Acta Veterinaria Brno 89, no. 2 (2020): 163–69. http://dx.doi.org/10.2754/avb202089020163.

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This study was conducted as an in vivo experiment in adult miniature pigs with the aim to test two new biomaterials. An iatrogenic defect was made into the central femoral diaphysis in the experimental animals and subsequently fixated by bridging plate osteosynthesis. Into the defect we implanted a cancellous autograft (control group), a pasty injectable scaffold (EXP A), and a porous 3D cylinder (EXP B). Radiological examination was performed in all animals at 0, 10, 20, 30 weeks after surgical procedure and histological assessment was performed. In the newly formed bone the osteoblastic acti

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Nesheiwat, F., WM Brown, and KM Healey. "Post-traumatic first metatarsal reconstruction using coralline hydroxyapatite." Journal of the American Podiatric Medical Association 88, no. 3 (March 1, 1998): 130–34. http://dx.doi.org/10.7547/87507315-88-3-130.

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Autogenous bone grafting has been the standard approach to reconstruction of trauma-induced metatarsal defects. However, this treatment has well-known disadvantages related to the harvesting, size, shape, and availability of autografts. The authors used a synthetic hydroxyapatite bone-graft substitute manufactured from a marine coral with a morphology similar to that of cancellous bone in the reconstruction of a large, post-traumatic first metatarsal defect. The authors found grafting with coralline hydroxyapatite to be a safe and effective substitute for autogenous bone grafting in the post-t

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Kashimada, K., T. Yamashita, K. Tsuji, A. Nifuji, S. Mizutani, Y. Nabeshima, and M. Noda. "Defects in growth and bone metabolism in klotho mutant mice are resistant to GH treatment." Journal of Endocrinology 174, no. 3 (September 1, 2002): 403–10. http://dx.doi.org/10.1677/joe.0.1740403.

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Klotho mutant (kl/kl) mice exhibit growth retardation after weaning, and previous electron microscopic examination of GH-producing cells in pituitary glands revealed a reduction in GH granules. However, it has not been known whether growth retardation in klotho mutant mice is related to the loss of GH function. We therefore examined whether treatment with GH could rescue the retardation of growth. At the end of 3 weeks of treatment with human GH, the body weight of wild-type (WT) mice was increased. In contrast, body weight was not increased in klotho mutant mice even after the treatment with

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22

Cockshutt, Joanne, A. B. Kuzma, and R. M. McLaughlin. "Stacked Veterinary Cuttable Plates for Treatment of Comminuted Diaphyseal Fractures in Cats." Veterinary and Comparative Orthopaedics and Traumatology 05, no. 01 (1992): 22–25. http://dx.doi.org/10.1055/s-0038-1633139.

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Comminuted long bone fractures in four cats were repaired using stacked 2.0/2.7 mm cuttable plates. The plates were used as “lengthening plates", spanning cortical defects to maintain limb length. The defects were filled with autogenous cancellous bone graft. The plates did not fracture through unfilled screw holes and good to excellent limb function returned in all four cats.

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Touré, A., M. Fusellier, B. Fellah, B. Bouvy, P. Weiss, O. Gauthier, and K. Minier. "BMP-2 delivered from a self-cross-linkable CaP/hydrogel construct promotes bone regeneration in a critical-size segmental defect model of non-union in dogs." Veterinary and Comparative Orthopaedics and Traumatology 27, no. 06 (2014): 411–21. http://dx.doi.org/10.3415/vcot-14-03-0036.

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SummaryObjectives: To determine whether the addition of recombinant human bone morphogenetic protein (rhBMP-2) to a self-crosslinkable cellulosic hydrogel/biphasic calcium phosphate (BCP) granules construct promotes bone healing in critical-size ulnar defects in dogs.Methods: A standardized 2 cm long ulnar ostectomy was performed bilaterally in five dogs to compare bone healing with hydrogel/BCP constructs associated with or without rhBMP-2. Cancellous-bone autografts were used as positive controls in unilateral ulnar defects in five additional dogs. Radiographically, bone healing was evaluate

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24

Muroi, Norihiro, Nobuo Kanno, Shuji Suzuki, Yasuji Harada, and Yasushi Hara. "Application of autologous cortical bone grafts for femoral non-union fractures in two dogs." Veterinary Record Case Reports 8, no. 1 (February 2020): e000826. http://dx.doi.org/10.1136/vetreccr-2019-000826.

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Two dogs with non-union fractures and osteomyelitis in the femoral diaphysis were referred to the authors’ hospital. During surgery, the defects were reconstructed using autologous cortical bones harvested from the contralateral femoral diaphysis. Graft fixation was performed by a double-plate technique in both cases. Autogenous cancellous bone was also grafted between the host bone and the graft in both cases. Antibiotics were administered for two to three weeks. In cases 1 and 2, no loosening of the implant or lameness was observed after 31 months and 10 months, respectively. Autologous cort

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Lin, Chun-Cheng, Shih-Chieh Lin, Chao-Ching Chiang, Ming-Chau Chang, and Oscar Kuang-Sheng Lee. "Reconstruction of Bone Defect Combined with Massive Loss of Periosteum Using Injectable Human Mesenchymal Stem Cells in Biocompatible Ceramic Scaffolds in a Porcine Animal Model." Stem Cells International 2019 (November 23, 2019): 1–8. http://dx.doi.org/10.1155/2019/6832952.

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Clinically, in patients who sustain severe open fractures, there is not only a segmental bone defect needed to be reconstructed but also insufficient healing capacity due to concomitant damages to the periosteum and surrounding soft tissues. For studying the reconstruction of bone defects associated with massive loss of periosteum and surrounding soft tissues, there are no well-established preclinical models in large animals in the literature. The purpose of the study was to generate a large animal model of bone defect with massive periosteum loss and to adopt a tissue engineering approach to

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Sagliyan, A., E. Karabulut, E. Unsaldi, and I. Yaman. "Evaluation of the activity of intraarticular hyaluronic acid in the repair of experimentally induced osteochondral defects of the stifle joint in dogs." Veterinární Medicína 54, No. 1 (February 11, 2009): 33–40. http://dx.doi.org/10.17221/3043-vetmed.

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The present study examined the results of using hyaluronic acid with autogenetic cancellous grafts in the treatment of experimentally induced osteochondral defects in the stifle joints of dogs. In this study, 10 mature dogs of different breeds, weights and of both sexes were used. General anesthesia and usual operation procedures were followed. A 10 mm deep defect was created on the femoral sulcus of the trochlea with a drill tip of 8 mm in diameter. The defects in the right and left legs were filled with autogenic cancellous grafts taken from the metaphysial region of the tibia. The left legs

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27

Primley, Donald M. "Dacron mesh tray and cancellous bone in reconstruction of mandibular defects." Journal of Oral and Maxillofacial Surgery 44, no. 10 (October 1986): 840. http://dx.doi.org/10.1016/0278-2391(86)90180-1.

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28

Albert, T. W., J. D. Smith, E. C. Everts, and T. A. Cook. "Dacron Mesh Tray and Cancellous Bone in Reconstruction of Mandibular Defects." Archives of Otolaryngology - Head and Neck Surgery 112, no. 1 (January 1, 1986): 53–59. http://dx.doi.org/10.1001/archotol.1986.03780010055010.

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29

JOHNSON, E. E., M. R. URIST, T. P. SCHMALZRIED, A. CHOTIVICHIT, H. K. HUANG, and G. A. M. FINERMAN. "Autogeneic Cancellous Bone Grafts in Extensive Segmental Ulnar Defects in Dogs." Clinical Orthopaedics and Related Research &NA;, no. 243 (June 1989): 254???265. http://dx.doi.org/10.1097/00003086-198906000-00039.

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30

Voor, Michael J., Eric M. Yoder, and Robert L. Burden. "Xenograft Bone Inclusion Improves Incorporation of Hydroxyapatite Cement Into Cancellous Defects." Journal of Orthopaedic Trauma 25, no. 8 (August 2011): 483–87. http://dx.doi.org/10.1097/bot.0b013e318224a3c2.

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Shaheen, Marwa Y., Amani M. Basudan, Abdurahman A. Niazy, Jeroen J. J. P. van den Beucken, John A. Jansen, and Hamdan S. Alghamdi. "Effect of Systemic Zoledronic Acid Dosing Regimens on Bone Regeneration in Osteoporotic Rats." Applied Sciences 11, no. 4 (February 22, 2021): 1906. http://dx.doi.org/10.3390/app11041906.

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The aim of this study was to evaluate the regeneration of bone defects created in the femoral condyle of osteoporotic rats, following intravenous (IV) zoledronate (ZA) treatment in three settings: pre-bone grafting (ZA-Pre), post-bone grafting (ZA-Post), and pre- plus post-bone grafting (ZA-Pre+Post). Twenty-four female Wistar rats were ovariectomized (OVX). After 12 weeks, bone defects were created in the left femoral condyle. All defects were grafted with a particulate inorganic cancellous bovine bone substitute. ZA (0.04 mg/kg, weekly) was administered to six rats 4 weeks pre-bone graft pla

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Ford, Samuel E., and J. Kent Ellington. "Management of Distal Tibial Metaphyseal Bone Defects With an Intramedullary Nitinol Scaffold: A Novel Technique." Foot & Ankle Specialist 10, no. 4 (November 21, 2016): 368–71. http://dx.doi.org/10.1177/1938640016679708.

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Difficult problems that are faced when reconstructing severe pilon fractures include filling metaphyseal defects and supporting an impacted, multifragmented articular surface. Supplements to plate fixation currently available in a surgeon’s armamentarium include cancellous bone autograft, structural bone allograft, demineralized bone matrix, and calcium-based cements. Cancellous autograft possesses limited inherent mechanical stability and is associated with graft site morbidity. Structural allografts incorporate inconsistently and are plagued by late resorption. Demineralized bone matrix also

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Al-Muaid, Jaleel, Mario Franciolli, and Kaj Klaue. "Tubular Remodeling of Massive Cancellous Bone Graft in the Treatment of Long Bone Defects." European Journal of Trauma and Emergency Surgery 33, no. 6 (May 15, 2007): 654–58. http://dx.doi.org/10.1007/s00068-007-6136-3.

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34

Matsushita, Takehiko, Shu Watanabe, Daisuke Araki, Tomoyuki Matsumoto, Koji Takayama, Masahiro Kurosaka, and Ryosuke Kuroda. "High tibial osteotomy combined with cancellous bone graft and osteochondral autograft transplantation in a patient with massive osteochondral defects in the medial femoral condyle." Journal of Orthopaedic Surgery 25, no. 1 (January 1, 2017): 230949901668501. http://dx.doi.org/10.1177/2309499016685016.

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Treatment of massive osteochondral defects of the medial femoral condyle is challenging. A 46-year-old man who had a medial femoral condyle fracture on his left knee underwent osteosynthesis in a hospital, but the pain remained and the patient was referred to our hospital 8 months after the surgery. Radiographs showed a varus alignment of the leg, and magnetic resonance image showed a massive necrotic area in the medial femoral condyle. The patient received high tibial osteotomy (HTO) combined with iliac cancellous bone graft and an osteochondral autograft transplantation. Pain and the knee fu

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35

Arts, J. J. C., J. W. M. Gardeniers, M. L. M. Welten, N. Verdonschot, B. W. Schreurs, and P. Buma. "TCP-HA Granules and Impacted Morselized Cancellous Bone Graft Mixes for Acetabular Reconstruction with the Bone Impaction Grafting Technique. A Loaded and Critical Sized Defect Model in the Goat." Key Engineering Materials 284-286 (April 2005): 869–72. http://dx.doi.org/10.4028/www.scientific.net/kem.284-286.869.

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With the bone impaction grafting technique, a 50/50 volume mix of morselized cancellous bone (MCB) with TCP-HA granules was used to reconstruct a critical sized acetabular defect in the goat. The biological activity of the MCB/TCP-HA mix was assessed after 15 weeks. Defects filled with 100% MCB, currently the gold standard for this technique, were used as controls. In the 100% MCB defects, a new trabecular bone structure was found in which scarce incorporated remnants of the original graft material were present. In the MCB/TCP-HA defects, MCB was also resorbed or incorporated into new bone. De

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Horstmann, Peter F., Werner H. Hettwer, and Michael M. Petersen. "Treatment of benign and borderline bone tumors with combined curettage and bone defect reconstruction." Journal of Orthopaedic Surgery 26, no. 3 (September 1, 2018): 230949901877492. http://dx.doi.org/10.1177/2309499018774929.

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Purpose: The management of bone defects following simple curettage of bone tumors is controversial and in light of the numerous emerging substitutes for bone grafts, we wished to review and report our experience with the use of cancellous allograft bone in the treatment of benign and borderline bone tumors. Methods: We reviewed the medical records of 164 consecutive patients with benign or borderline bone tumors treated with simple curettage at our orthopedic oncology center between 2009 and 2013. Postoperative radiological changes were evaluated by a modified Neer’s classification in defects

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Lewis, Christine S., Jordan Katz, Maribel I. Baker, Peter R. Supronowicz, Elise Gill, and Ronald R. Cobb. "Local Antibiotic Delivery with Bovine Cancellous Chips." Journal of Biomaterials Applications 26, no. 4 (September 6, 2010): 491–506. http://dx.doi.org/10.1177/0885328210375729.

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Infected bone defects and osteomyelitis are encountered frequently in trauma cases. Currently, the standard of care for osteomyelitis cases is prolonged systemic antibiotic therapy and implantation of antibiotic carrier beads. However, this method requires a secondary surgery to remove the beads after the infection has cleared. In the present study a common bone void filler was investigated for its ability to be infused with an antibiotic. This study demonstrates that the xenograft material tested can be loaded with gentamicin and release clinically relevant levels of the drug for at least 14

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Henrich, Dirk, Kerstin Wilhelm, Joerg Warzecha, Johannes Frank, John Barker, Ingo Marzi, and Caroline Seebach. "Human Endothelial-Like Differentiated Precursor Cells Maintain Their Endothelial Characteristics When Cocultured with Mesenchymal Stem Cell and Seeded onto Human Cancellous Bone." Mediators of Inflammation 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/364591.

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Introduction. Cancellous bone is frequently used for filling bone defects in a clinical setting. It provides favourable conditions for regenerative cells such as MSC and early EPC. The combination of MSC and EPC results in superior bone healing in experimental bone healing models.Materials and Methods. We investigated the influence of osteogenic culture conditions on the endothelial properties of early EPC and the osteogenic properties of MSC when cocultured on cancellous bone. Additionally, cell adhesion, metabolic activity, and differentiation were assessed 2, 6, and 10 days after seeding.Re

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Enemark, Hans, John Jensen, and Carles Bosch. "Mandibular Bone Graft Material for Reconstruction of Alveolar Cleft Defects: Long-Term Results." Cleft Palate-Craniofacial Journal 38, no. 2 (March 2001): 155–63. http://dx.doi.org/10.1597/1545-1569_2001_038_0155_mbgmfr_2.0.co_2.

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Objective To analyze the long-term effect of mandibular bone as donor material in bone grafting of the alveolar process defect in patients with unilateral cleft lip and palate (UCLP), compared with iliac crest cancellous bone. Method During a 7-year period, 101 UCLP patients were bone grafted, 57 cases with iliac crest cancellous bone and 44 with mandibular symphyseal bone. The long-term results with an observation time of more than 4 years were analyzed with respect to marginal bone level and dental and gingival condition in the grafted area. Complications were recorded. Results The bone leve

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Gellrich, N. C., G. Hauschild, M. Fehr, K. H. Bormann, K. Rohn, S. Spalthoff, M. Rücker, H. Kokemüller та M. C. Nolff. "Comparison of two β-tricalcium phosphate composite grafts used for reconstruction of mandibular critical size bone defects". Veterinary and Comparative Orthopaedics and Traumatology 22, № 02 (2009): 96–102. http://dx.doi.org/10.3415/vcot-08-04-0038.

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Summary Objective: The aim was to compare osseointegration of blood perfused β-tricalcium phosphate cylinders (β-TCPB) with similar composites that were additionally loaded with cancellous bone and bone marrow (β-TCPB/BM/CB) for mandibular reconstruction. Methods: Twelve German Black-Headed sheep with an average weight of 72.5 ± 10 kg underwent segmental re-section of the right hemi-mandible. The animals that were assigned to group A (n=6) were reconstructed using β-TCPB while the sheep that were assigned to group B received β-TCPB/BM/CB grafts. Tissue quality was histologically assessed and b

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Silva, R. V., J. A. Camilli, C. A. Bertran, and N. H. Moreira. "The use of hydroxyapatite and autogenous cancellous bone grafts to repair bone defects in rats." International Journal of Oral and Maxillofacial Surgery 34, no. 2 (March 2005): 178–84. http://dx.doi.org/10.1016/j.ijom.2004.06.005.

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van Dyk, GE, LM Dejardin, G. Flo, and LL Johnson. "Cancellous bone grafting of large osteochondral defects: an experimental study in dogs." Arthroscopy: The Journal of Arthroscopic & Related Surgery 14, no. 3 (April 1998): 311–20. http://dx.doi.org/10.1016/s0749-8063(98)70148-3.

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Pereira, G. C. T., E. N. Kubiak, B. Levine, F. S. Chen, and P. E. Di Cesare. "Cavitary acetabular defects treated with morselized cancellous bone graft and cementless cups." International Orthopaedics 31, no. 4 (September 19, 2006): 445–50. http://dx.doi.org/10.1007/s00264-006-0220-x.

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Šponer, Pavel, Tomáš Kučera, Jindra Brtková, Karel Urban, Zuzana Kočí, Pavel Měřička, Aleš Bezrouk, Šimona Konrádová, Alžběta Filipová, and Stanislav Filip. "Comparative Study on the Application of Mesenchymal Stromal Cells Combined with Tricalcium Phosphate Scaffold into Femoral Bone Defects." Cell Transplantation 27, no. 10 (September 11, 2018): 1459–68. http://dx.doi.org/10.1177/0963689718794918.

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This prospective study sought to evaluate the healing quality of implanted ultraporous β-tricalcium phosphate sown with expanded autologous mesenchymal stromal cells (MSCs) into femoral defects during revision hip arthroplasty. A total of 37 osseous defects in 37 patients were treated and evaluated concerning bone regeneration. Nineteen subjects received β-tricalcium phosphate graft material serving as a carrier of expanded autologous MSCs (the trial group A), nine subjects received β-tricalcium phosphate graft material only (the study group B) and nine subjects received cancellous allografts

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Lu, Jian, Qi-Yang Wang, and Jia-Gen Sheng. "Exosomes in the Repair of Bone Defects: Next-Generation Therapeutic Tools for the Treatment of Nonunion." BioMed Research International 2019 (August 4, 2019): 1–11. http://dx.doi.org/10.1155/2019/1983131.

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Nonunion with bone defects, a common complication after long bone fracture, is a major challenge for orthopaedic surgeons worldwide because of the high incidence rate and difficulties in achieving successful treatment. Bone defects are the main complications of nonunion. The conventional biological treatments for nonunion with bone defects involve the use of autologous bone grafts or bone graft substitutes and cell-based therapy. Traditional nonunion treatments have always been associated with safety issues and various other complications. Bone grafts have limited autologous cancellous bone an

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Giavaresi, Gianluca, Milena Fini, Jonathan Salvage, Nicolò Nicoli Aldini, Roberto Giardino, Luigi Ambrosio, Luigi Nicolais, and Matteo Santin. "Bone regeneration potential of a soybean-based filler: experimental study in a rabbit cancellous bone defects." Journal of Materials Science: Materials in Medicine 21, no. 2 (September 22, 2009): 615–26. http://dx.doi.org/10.1007/s10856-009-3870-6.

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Markel, M. D., and P. D. Hanson. "Bone and Cartilage Transplantation." Veterinary and Comparative Orthopaedics and Traumatology 05, no. 04 (1992): 163–69. http://dx.doi.org/10.1055/s-0038-1633104.

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SummaryBone and cartilage transplantation have included autogenic, allogenic, and xenogenic tissues. Non-vascular cortical bone grafts are incorporated through a process of resorption, vascular invasion, and new bone deposition. Cancellous grafts are incorporated through a process of bone deposition followed by resorption. A variety of proteins, enzymes and enzyme inhibitors, collectively termed osteogenins, have been identified to have osteo-inductive activity. The incorporation of cartilage grafts differs from that of bone in several ways, largely due to differences in nutrition of the graft

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Djapic, T., V. Kusec, M. Jelic, S. Vukicevic, and M. Pecina. "Compressed homologous cancellous bone and bone morphogenetic protein (BMP)-7 or bone marrow accelerate healing of long-bone critical defects." International Orthopaedics 27, no. 6 (December 1, 2003): 326–30. http://dx.doi.org/10.1007/s00264-003-0496-z.

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Chan, Yi-Sheng, Steve Wen-Neng Ueng, Ching-Jen Wang, Shiuann-Sheng Lee, En-Kai Chao, and Chun-Hsiung Shin. "Management of Small Infected Tibial Defects with Antibiotic-Impregnated Autogenic Cancellous Bone Grafting." Journal of Trauma: Injury, Infection, and Critical Care 45, no. 4 (October 1998): 758–64. http://dx.doi.org/10.1097/00005373-199810000-00023.

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Gogolewski, Sylwester, and Katarzyna Gorna. "Biodegradable polyurethane cancellous bone graft substitutes in the treatment of iliac crest defects." Journal of Biomedical Materials Research Part A 80A, no. 1 (January 2007): 94–101. http://dx.doi.org/10.1002/jbm.a.30834.

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