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Dissertations / Theses on the topic 'Cancer and medicinal'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Shi, Dong-Fang. "The medicinal chemistry of antitumour benzazoles." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283645.

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2

Vasconcellos, Maria Carolina Bayeux Leme Montanari de. "Atividade antitumoral, isolamento e identificação dos principios ativos da Kielmeyera coriacea Mart & Zucc." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317829.

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Orientador: João Ernesto de Carvalho, Mary Ann Foglio<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-12T10:21:24Z (GMT). No. of bitstreams: 1 Vasconcellos_MariaCarolinaBayeuxLemeMontanaride_D.pdf: 13749681 bytes, checksum: 04f58739b213e3f9a71a8aac87660d56 (MD5) Previous issue date: 2008<br>Resumo: Kielmeyera coriacea Mart & Zucc (Clusiacea), conhecida popularmente como PauSanto (Alves e caL, 2000), foi uma das espécies do Cerrado que apresentou atividade antiproliferativa significativa em ensaios preliminares, sendo então

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3

Waheed, Abdul. "Isolation and characterisation of potential anticancer compounds from medicinal plants." Thesis, Kingston University, 2011. http://eprints.kingston.ac.uk/22906/.

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The research work presented in this thesis deals with the anticancer activity of four medicinal plants: 'Caralluma tuberculata' (Asclepiadaceae), 'Fagonia indica' (Zygophyllaceae), 'Solanum surattense' (Solanaceae) and 'Arisaema utile' (Araceae) that originate from the North West and Himalayan regions of Pakistan. Through a bioactivity-guided fractionation approach, the crude and resultant organic fractions were tested on cultured breast cancer cells (MCF-7 and MDA MB-468) and colorectal carcinoma cells (Caco-2) in vitro. Five new compounds out of seven in total were isolated from potent fract

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4

Baatjies, Lucinda. "In vitro cytotoxic effects of selected Nigerian medicinal plant extracts on cancer cell lines." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/d1008191.

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Cancer is a disease that imposes a heavy burden on public health and poses a challenge to science. The World Health Organization estimates that 80 percent of people in developing countries of the world rely on traditional medicine for their primary health needs, and about 85 percent of traditional medicine involves the use of plant extracts. This is particularly true in Africa where a large percentage of the population depends upon medicinal plants for health care. Therefore, detailed screening and evaluation of bioactive substances for chemotherapeutic purposes of African plants are urgently

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5

Borges, Dayane Oliveira. "Ensaio Clínico randomizado Inclusão da terapia complementar no manejo da êmese e mucosite em pacientes oncológicos /." Botucatu, 2019. http://hdl.handle.net/11449/181861.

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Orientador: Regina Célia Popim<br>Resumo: A presença de náusea, vômitos e mucosite são relatos frequentes em pacientes com câncer em quimioterapia. O presente estudo teve por objetivo a utilização de gengibre e camomila no manejo da êmese e mucosite nos pacientes com câncer de mama e pulmão em quimioterapia. Método: Trata-se de ensaio clínico randomizado, no qual foram incluídos 73 pacientes, sendo 48 com câncer de mama e 25 com câncer de pulmão, dos quais 24 e 11, respectivamente, constituíram o grupo controle. O grupo controle recebeu as orientações convencionais da instituição e o grupo exp

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6

Techatanawat, Isariya. "Chemistry and cytotoxic activity of some Thai medicinal plants used to treat cancer." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427990.

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7

KHALIL, MOHAMAD. "Phytochemical composition and biological activity of extracts from Lebanese medicinal plants." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/1002418.

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The Mediterranean area especially the eastern part including Lebanon, is rich in term of plant biodiversity, including high valuable medicinal plants that are largely used by people as herbal medicine, these plants represent an important source of plant-derived bioactive compounds, besides, there is a need to characterize these compounds, evaluate their bioactivity and clarify scientifically the use of these plant as traditional and alternative medicine, lack of these information may limit their use, by contrast, studying the compositions and bioactivity of these plants may improve their use,

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8

McClymont, Kyle Stephen. "Novel SMAC Mimetics as Peptide-based Small Molecule Inhibitors of IAPs to Induce Apoptosis in Cancer Cells." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32795.

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SMAC (Secondary Mitochondria-derived Activator of Caspases) mimetics have generated significant interest as potential chemotherapeutic compounds via their ability to promote apoptosis in cancer cells. These molecules target several Inhibitor of Apoptosis Proteins (IAPs) whose elevated expression is ubiquitous with tumorigenesis. We report several novel SMAC based peptidomimetics which appear to mirror the anti-IAP activity of SMAC in vitro. Elements of reported SMAC mimetics were combined with unique structural features to design novel, efficacious IAP antagonists. Our approach included modifi

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9

Singh, Shilpa. "SYNTHESIS AND BIOLOGICAL EVALUATION OF SECOND GENERATION ANIBAMINE ANALOGUES AS NOVEL ANTI-PROSTATE CANCER AGENTS." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/359.

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Prostate cancer is the most prevalent non-cutaneous cancer among men. Since the 19th century when Virchow first introduced the concept of inflammation in cancer, chemokines and their receptors have garnered a lot of interest. Chemokine receptor CCR5 has been especially implicated in many disease states and recently found to be over expressed in prostate cancer cell lines. Anibamine, a natural CCR5 antagonist discovered in 2004, has been found to have significant anti-prostate cancer activity at micromolar level. To optimize this compound and also discover a novel pharmacophore, exploration of

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10

Zhang, Chao. "Anti-liver cancer effect of polyphyllin VII and its molecular mechanisms." Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3690802.

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11

Dalela, Manu. "Synthesis, characterization and biological evaluation of poly(styreneco-maleic anhydride) as a drug delivery vehicle for cancer therapy." Thesis, IIT Delhi, 2016. http://localhost:8080/xmlui/handle/12345678/7037.

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12

Horniblow, Richard David. "The use of alginates and polyphenols in medicinal iron chelation for the improvement of colonic health." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6663/.

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Iron is central to the aetiology of gastrointestinal disease. Specifically, the toxic effects of excess, unabsorbed "luminal" iron ingested from the diet has been shown to be important in the development of inflammatory bowel disease and intestinal cancer. A platform for therapeutic intervention is likely to involve chelation of this luminal pool of iron. As such, a range of dietary iron chelators have been tested for their iron binding capacity. Natural biopolymers extracted from seaweed (alginates) and a variety of natural polyphenolic compounds were stratified in terms of their iron binding

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13

Mbandezi, Yamkela. "Evaluation of cytotoxic activity of gold nanoparticles naturally synthesised from South African indigenous medicinal plant extracts." University of the Western Cape, 2018. http://hdl.handle.net/11394/6786.

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>Magister Scientiae - MSc<br>Nanotechnology has emerged as a promising field in the quest to address health conditions. Green nanotechnology is a fairly new branch of nanotechnology, which aims to produce and utilize nanomaterials in a way that is safe for living organisms and their environment. Plant extracts are increasingly used in the green synthesis of gold nanoparticles (AuNPs), which involves the reduction of sodium tetrachloroaurate (III) dehydrate by phytochemicals present in the plant extract. It is probable that the green synthesised AuNPs are more biocompatible than chemically synt

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14

ALMEIDA, Marcel Lucas de. "Síntese, caracterização e atividade biológica de novos derivados e atividade biológica de novos derivados da 3-(acridina-9-imetil) tiazolidina-2,4-diona." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/16873.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-04-29T14:00:29Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Minha dissertação final para biblioteca.pdf: 6771552 bytes, checksum: cc238895a0629230ce30655a760f5a10 (MD5)<br>Made available in DSpace on 2016-04-29T14:00:29Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Minha dissertação final para biblioteca.pdf: 6771552 bytes, checksum: cc238895a0629230ce30655a760f5a10 (MD5) Previous issue date: 2015-02-19<

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15

Chen, Yi-Chun. "Bioactivities of selected Sutherlandia frutescens (L.) R. Br. leaf extracts." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5035.

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Thesis (M.S.)--University of Missouri-Columbia, 2007.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on October 23, 2007) Includes bibliographical references.

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16

Vaidergorn, Miguel de Menezes. "Desenvolvimento de uma biblioteca de ?-aminoálcoois o álcoois e aziridinas com potencial atividade antitumoral." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/60/60138/tde-12122016-163124/.

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O anel aziridínico é conhecido desde o final do século XIX e apresenta alta reatividade devido a sua alta energia de ligação e tensão do anel, o que o torna um valioso aliado na síntese orgânica, especialmente em reações com nucleófilos. Estas características também o tornam reativo frente à nucleófilos biológicos, tais como os ácidos nucléicos. Tal fato leva a uma toxicidade celular e pode ser dirigida a substratos específicos, como no caso de quimioterápicos, levando à alquilação de DNA em células tumorais. Este anel pode ser sintetizado a partir de ?-aminoálcoois, cuja classe de compostos a

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17

Wang, Yue. "Exploration of the novel anticancer mechanisms of medicinal compounds involving calpain and S100A4 in the treatment of colon cancer." HKBU Institutional Repository, 2016. http://repository.hkbu.edu.hk/etd_oa/270.

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In summary, this thesis has explored the anti-cancer mechanisms of novel medicinal compounds via targeting calpains or S100A4 in the treatment of colon cancer, which could facilitate future establishment of effective medicinal compounds in the treatment of metastatic colon cancers with known molecular targets.;The incidence of colon cancer in Hong Kong and worldwide is on a rising trend, while its metastatic development is the leading cause of cancer-related deaths. Understanding the molecular mechanisms of how tumors progress and metastasize to secondary sites, at both biological and genetic

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18

Zhong, Zhang Feng. "Evaluation of the anti-breast cancer activities of furanodiene and germacrone isolated from Chinese medicine Rhizoma curcumae." Thesis, University of Macau, 2011. http://umaclib3.umac.mo/record=b2524999.

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19

Yang, Xiaotong, and 楊曉彤. "The anticancer mechanisms of polysaccharide peptide (PSP) derived fromthe Chinese medicinal fungus coriolus versicolor." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31246229.

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20

Burroughs, Sarah. "Design and Synthesis of HIF-1 Inhibitors as Anti-cancer Therapeutics." Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/chemistry_diss/78.

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Cancer is responsible for one fourth of the total deaths and is the second leading cause of death, behind heart disease, in the United States. However, there are as many approaches to curing cancer as there are types of cancer. One important issue in solid tumors is hypoxia, a lack of oxygen, which promotes angiogenesis and anaerobic metabolism, which can increase cancer progression and metastasis. The HIF transcription factor is responsible for the mediation of many processes involved during hypoxia and is linked to poor patient prognosis, increased cancer progression, and invasiveness of tum

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21

Essack, Magbubah. "Screening extracts of indigenous South African plants for the presence of anti-cancer compounds." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_8767_1210844967.

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<p>Early man dabbled with the use of plant extracts to cure ailments. This practice has been passed down from generation to generation and today more than 50% of the world'sdrugs are natural products or derivatives thereof. Scientists have thus established a branch of research called natural product research. This branch of research involves the identification and purification of secondary metabolites with a specific biological activity. The methodology involves the screening of plant products for a specific biological activity, purification of the biologically active natural product by separa

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22

Meyers, Ross Owen. "Anticancer Structure-Activity Relationships of Semi-Synthetic Analogs of Nordihydroguaiaretic Acid." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1086%5F1%5Fm.pdf&type=application/pdf.

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23

Choi, Bong-Jin. "Statistical Analysis, Modeling, and Algorithms for Pharmaceutical and Cancer Systems." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5200.

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The aim of the present study is to develop a statistical algorithm and model associ- ated with breast and lung cancer patients. In this study, we developed several statistical softwares, R packages, and models using our new statistical approach. In the present study, we used the five parameters logistic model for determining the optimal doses of a pharmaceutical drugs, including dynamic initial points, an automatic process for outlier detection and an algorithm that develops a graphic user interface(GUI) program. The developed statistical procedure assists medical scientists by reducing their

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24

Smith, Breland Elise. "Small Molecule Approaches Toward Therapeutics for Alzheimer's Disease and Colon Cancer." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/337213.

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The research described in this dissertation is focused on the knowledge-based, often in silico assisted design, targeted synthesis, and biological evaluation of small molecules of interest for two translational medicinal chemistry projects. The first project (Part 1) is aimed at the identification of blood brain barrier (BBB) penetrable dual specificity tyrosine phosphorylation regulated kinase-1A (DYRK1A) inhibitors as a potential disease modifying approach to mitigate cognitive deficits associated with Alzheimer's neurodegeneration. Two major series with potent activity against DYRK1A were i

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25

Maia, Pedro Ivo da Silva. "Complexos de interesse medicinal em terapia ou diagnóstico, envolvendo os elementos Au, Pd, Pt, Re e Tc, com tiossemicarbazonas S,N,S-tridentadas." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-01022012-160613/.

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Esta tese apresenta a síntese de uma nova classe de tiossemicarbazonas/tiossemicarbazidas (H2L1) potencialmente S,N,S-doadoras, obtida através de reações entre cloreto de N-[N\',N\'-dialquilamino(tiocarbonil)]benzimidoílas e 4,4-dialquiltiossemicarbazidas, as quais apresentaram um efeito citotóxico bastante promissor contra células de câncer de mama humano da linhagem MCF-7. Estas tiossemicarbazonas foram utilizadas na preparação de novos complexos de metais de transição, incluindo os elementos Au, Pd, Pt, Re e Tc, os quais foram caracterizados com base em espectroscopias no IV, absorção

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26

Uddin, Shaikh Jamal. "Cytotoxicity Screening of Bangladeshi Medicinal Plants and Isolation and structural Elucidation of Novel Anti-Cancer Compounds from Acrostichum aureum." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/365889.

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This thesis describes the cytotoxicity and phytochemical screening of 16 selected medicinal plants collected from the tidal forests of the coastal Sundarban and locations within the Khulna district of Bangladesh. The selected plants were successively extracted with n-hexane, dichloromethane, methanol and water. The methanol and aqueous extracts were then screened for cytotoxic activity (MTT assay) against one normal mouse fibroblast and three human cancer cell lines (gastric, colon and breast cancer). The results supported some of the traditional uses and reported cytotoxic activity for some o

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27

Parenti, Marco Daniele <1975&gt. "Cancer and aging: a multidisciplinary medicinal chemistry approach on relevant biological targets such as proteasome, sirtuins and interleukin 6." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6801/1/parenti_marcodaniele_tesi.pdf.

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It is well known that ageing and cancer have common origins due to internal and environmental stress and share some common hallmarks such as genomic instability, epigenetic alteration, aberrant telomeres, inflammation and immune injury. Moreover, ageing is involved in a number of events responsible for carcinogenesis and cancer development at the molecular, cellular, and tissue levels. Ageing could represent a “blockbuster” market because the target patient group includes potentially every person; at the same time, oncology has become the largest therapeutic area in the pharmaceutical industr

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Parenti, Marco Daniele <1975&gt. "Cancer and aging: a multidisciplinary medicinal chemistry approach on relevant biological targets such as proteasome, sirtuins and interleukin 6." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6801/.

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It is well known that ageing and cancer have common origins due to internal and environmental stress and share some common hallmarks such as genomic instability, epigenetic alteration, aberrant telomeres, inflammation and immune injury. Moreover, ageing is involved in a number of events responsible for carcinogenesis and cancer development at the molecular, cellular, and tissue levels. Ageing could represent a “blockbuster” market because the target patient group includes potentially every person; at the same time, oncology has become the largest therapeutic area in the pharmaceutical industr

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29

Du, Boulay Courtney Jerome. "Virtual Screening for Inhibitors of Anti-apoptotic Proteins: DCK, BCL-XL, MCL-1, MDMX, and MDM2." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4664.

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←Within this dissertation the topic of virtual screening is discussed with regard to three different cancer targets and also a brief introduction of the tools used in virtual screening. In Chapter 1, the reader will be introduced to virtual screening and the programs that are used in virtual screening. In Chapter 2, the first of three projects are discussed. This project consists of the work that was done to find inhibitors of the P53 binding domain of MDMX. In this project the mobility of residues within the binding site of MDMX are discussed and the ways in which we attempted to model h

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30

Miller, Zachary C. "THE DEVELOPMENT OF NOVEL NON-PEPTIDE PROTEASOME INHIBITORS FOR THE TREATMENT OF SOLID TUMORS." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacy_etds/87.

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The proteasome is a large protein complex which is responsible for the majority of protein degradation in eukaryotes. Following FDA approval of the first proteasome inhibitor bortezomib for the treatment of multiple myeloma (MM) in 2003, there has been an increasing awareness of the significant therapeutic potential of proteasome inhibitors in the treatment of cancer. As of 2017, three proteasome inhibitors are approved for the treatment of MM but in clinical trials with patients bearing solid tumors these existing proteasome inhibitors have demonstrated poor results. Notably, all three FDA-ap

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31

Huang, Jie Min. "An amentoflavone derivative induces apoptosis and interferes with cell proliferation in melanoma by inhibition of the JAK2STAT3 signaling pathway." Thesis, University of Macau, 2017. http://umaclib3.umac.mo/record=b3690910.

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32

Zhu, Peili. "Anti-hepatocellular carcinoma mode and mechanism of action of antrodia camphorata mycelia." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/605.

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Hepatocellular carcinoma (HCC), the major form of primary liver cancer, is a common cause of cancer-related death worldwide. Signal transducer and activator of transcription 3 (STAT3) plays a pivotal role in the pathogenesis of HCC. Inhibition of STAT3 signaling has been proposed as a promising strategy for treating HCC. Due to the limitations of conventional therapeutics, increasing attention has been paid to complementary and alternative medicines (CAM) including traditional Chinese medicine (TCM) for the management of HCC. Antrodia camphorata (AC), a medicinal mushroom, is historically used

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33

Xie, Yanqi. "SEMISYNTHETIC AURONES: A FAMILY OF NEWLY DISCOVERED TUBULIN INHIBITORS AS ANTINEOPLASTIC AGENTS." UKnowledge, 2019. https://uknowledge.uky.edu/biochem_etds/44.

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Aurones belong to an uncommon class of plant flavonoids that provide the bright yellow coloration of some ornamental flowers and that possess a range of biological activities. Structure-activity relationships (SAR) in the aurone pharmacophore identified heterocyclic variants of the (Z)-2-benzylidene-6-hydroxybenzofuran-3(2H)-one scaffold that possessed low nanomolar in vitro potency in cell proliferation assays using various cancer cell lines, in vivo potency in prostate cancer PC-3 xenograft and zebrafish models, selectivity for the colchicine-binding site on tubulin, and absence of appreciab

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Essel, Augustine. "Synthesis of a Water Soluble Resveratrol Derivative as a Potential Anti-Cancer Drug." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etd/1738.

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Research on development of water soluble anti-cancer drugs is one of the great challenges of modern medicinal chemistry. Resveratrol (Res) is one of the many phytoalexins producing stilbenoids present in several medicinal plants, grape skin, peanuts, and red wine. It has been found to exhibit anti-cancer, anti-inflammatory, and anti-oxidant properties. Water solubility and bioavailability are some of the setbacks of this interesting compound. In view of this, effort has been made to synthesize amino acid derivative of resveratrol to improve its bioavailability and solubility in water. Methyl 4

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35

Hui, Pui-yan, and 許珮茵. "The combined effect of Chinese medicinal extract polysaccharide peptide (PSP) and the chemotherapeutic agents-cytarabine, doxorubicinand etoposide in human leukemic cells and normal human T-lymphocytes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B27776311.

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Miller, Andrew B. "Antimicrobial and Anticancer Activity of Essential Oils from Guatemalan Medicinal Plants." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2411.

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Guatemalan medicinal plants were collected and screened for the presence of essential oils using steam distillation. Oil was found in 63 species from 24 families and was tested in tube dilution assays for activity against Escherichia coli, Staphylococcus aureus, Streptococcus mutans, Lactobacillus acidophilus and Candida albicans. Several essential oils were highly active with 20 instances of oils inhibiting the microbes at an MIC of 0.31 µl/ml. Oils were also tested against cancerous and established cell lines using a 15% (v/v) agar-media which was developed to improve essential oil solubilit

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37

Bailey, Helen Victoria. "Drug design and novel anti-cancer therapeutics : inhibitors of 17β hydroxysteroid dehydrogenase type 3". Thesis, University of Bath, 2007. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512267.

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Herein, we describe the design and synthesis of novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 which convert androstenedione into testosterone, which is then converted into dihydrotestosterone (DHT). This isozyme has been implicated in the growth of prostate cancer. Using an in silico pharmacophore model initial targets were planned, based around a diphenylether hydrophobic head linked to a 4-substituted piperidine ring. Over 45 compounds were synthesised and many show significant biological activity when evaluated in a 17β-HSD type 3 biological assay. The most potent compound in

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Babanyinah, Godwin Kweku. "Theranostic Nanoparticles Folic Acid-Carbon Dots-Drug(s) for Cancer." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/etd/3892.

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This study aims to prepare theranostic nanoparticles (NPs) that are expected to increase cancer diagnostics and therapeutic efficacy. We prepared the NPs constituting carbon dots (CDs) as an imaging agent, folic acid as a targeting agent, doxorubicin (DOX), or gemcitabine (GEM) as chemotherapy agents. The NPs include noncovalent FA-CDs-DOX, covalent CDs-FA-DOX, and covalent FA-CDs-GEM. Through ultraviolet-visible spectroscopy, fluorescence spectroscopy, and Fourier transform-infrared spectroscopy, the fabrication of these NPs was confirmed. It was discovered that the high drug loading efficien

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Cruz, Elisa Castañeda Santa. "Estudo de novas moléculas antitumorais em linhagens de células de câncer de próstata e mama hormônio-dependentes." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-09112015-161010/.

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Os cânceres de próstata e de mama estão entre as neoplasias mais comuns diagnosticadas na população ocidental. No Brasil, estes dois tipos de neoplasia são as principais causas de morte cuja incidência continua crescendo anualmente, sendo mais comum na população acima de 40 anos. As terapias utilizadas para os tratamentos de ambas as neoplasias estão baseadas principalmente nos receptores de hormônio (andrógeno e estrógeno). Embora muitos fármacos tenham sido desenvolvidos para os tratamentos destas patologias ao longo do tempo, eles perdem eficácia em caso de neoplasias resistentes, que apres

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Cadorette, Veronica R. "Chemical investigation of Dicranum fulvum for anticancer activity." Thesis, Virginia Tech, 1989. http://hdl.handle.net/10919/44706.

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<p>Biological screening of extracts of various bryophytes showed that the species Dicranum fulvum gave extracts with activity in both <u>in vitro</u> and <u>in vivo</u> bioassays. This plant was thus selected for extraction and fractionation, monitored by i<u>in vitro</u> bioassays.</p> <p>Isolation was guided by a combination of bioassay and chemical methods, and led to the isolation of three compounds, betulin, 9,l9- cyclolanostâ 23â eneâ 3,25â diol, and B-sitosterol. Purification was achieved by open column, flash column, gel filtration, thin layer chromatography, the chromatotr

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Shah, Khyati Niral. "Mechanism of tamoxifen resistance in breast cancer." Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/138.

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Acquired tamoxifen resistance develops in the majority of hormone responsive breast cancers and frequently involves overexpression of the PI3K/AKT axis. Here, breast cancer cells, with elevated endogenous AKT or overexpression of activated AKT exhibited tamoxifen-stimulated cell proliferation and enhanced cell motility. To gain mechanistic insight on AKT-induced endocrine resistance, gene expression profiling was performed to determine the transcripts that are differentially expressed post-tamoxifen therapy under conditions of AKT overexpression. Consistent with the biological outcome, many of

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Liao, Yueh Ying. "The Reaction of a Water Soluble Platinum Compound with Methionine and Derivatives." TopSCHOLAR®, 2010. http://digitalcommons.wku.edu/theses/153.

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Water soluble platinum complexes are a recent area of emphasis of cisplatin chemistry. The water soluble complexes could have a reduced toxicity compared with cisplatin. Oxaliplatin, which has an oxalate leaving group, has previously been shown to have less nephro-toxicity and higher water solubility than cisplatin. [Pt(en)(oxalate)] (en = ethylenediamine) has been prepared from Pt(en)Cl2 and silver oxalate. This complex has been reacted with methionine and N-acetylmethionine at different molar ratios. At high Pt: methionine ratios, chelates with the sulfur and nitrogen atoms of the methionine

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Huang, Yingbo. "Intrapulmonary Inoculation of Multicellular Tumor Spheroids to Construct an Orthotopic Lung Cancer Xenograft Model that Mimics Four Clinical Stages of Non-small Cell Lung Cancer." Scholarly Commons, 2019. https://scholarlycommons.pacific.edu/uop_etds/3596.

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Lung cancer leads in mortality among all types of cancer in the US and Non-small cell lung cancer (NSCLC) is the major type of lung cancer. Immuno-compromised mice bearing xenografts of human lung cancer cells represent the most common animal models for studying lung cancer biology and for evaluating potential anticancer agents. However, orthotopic lung cancer models based on intrapulmonary injection of suspended cancer cells feature premature leakage of the cancer cells to both sides of the lung within five days, which generates a quick artifact of metastasis and thus belies the development a

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Dattani, Poonam. "Development and Characterization of LDV Peptide Targeted Nanocarriers for Paclitaxel Delivery: A Comparative Study of Micelles, Liposomes and Solid Lipid Nanoparticles." Scholarly Commons, 2019. https://scholarlycommons.pacific.edu/uop_etds/3623.

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Nanocarriers have been established as delivery vehicles to target cancer tumors. However, premature drug leakage is one of the major reasons for inefficient drug delivery of nanocarriers to the tumor. Drug diffusion out of the nanocarriers or destabilization of drug loaded nanocarriers by physiological interactions with blood cells, serum proteins, and cell membranes upon systemic administration contribute to premature drug release. In this study, targeted micelles, liposomes and solid lipid nanoparticles (SLNs) of similar composition were prepared and characterized to compare physicochemical

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Tawfike, Ahmed. "Metabolomics and dereplication studies of endophytic metabolites from some Egyptian medicinal plants in the search for new potential anti-cancer and antimicrobial drugs." Thesis, University of Strathclyde, 2015. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=25719.

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Endophytes are microbes that inhabit living, internal tissues of plants without causing any immediate, apparent negative effects. Endophytic fungi associated with medicinal plants represent a potential source of novel chemistry and biology. This study involved isolation of three endophytic fungal strains from two Egyptian medicinal plants, Terminalia laxiflora and Markhamia platicalyx. Identification of the strains has been achieved through molecular biological methods. Metabolomic profiling, using 2D-NMR and HR-ESIFTMS were done at different stages of the growth phase for both solid and liqui

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Barbosa, Círia Vieira. "Avaliação do potencial antineoplásico de plantas medicinais utilizadas como coadjuvantes no tratamento do câncer pelos pacientes do CACON / UFAL." Universidade Federal de Alagoas, 2009. http://repositorio.ufal.br/handle/riufal/914.

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Plants have been used as sources of medicinal agents for millennia. Plant extracts and derived active principles have served as a major source for new pharmaceuticals for treatment of malignant tumors. In this work, we described the plants most used as anticancer agents, by the population treated on the Oncology Service of the University Hospital (Maceió-AL). The aim of this work was evaluate the toxicological effects of those plants and to value the antitumoral activity of the extracts and juices against human tumor cell lines and in neoplasic assays in vivo. Initially, the plants were collec

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Vankayala, Sai Lakshmana Kumar. "Computational Approaches for Structure Based Drug Design and Protein Structure-Function Prediction." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4601.

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This dissertation thesis consists of a series of chapters that are interwoven by solving interesting biological problems, employing various computational methodologies. These techniques provide meaningful physical insights to promote the scientific fields of interest. Focus of chapter 1 concerns, the importance of computational tools like docking studies in advancing structure based drug design processes. This chapter also addresses the prime concerns like scoring functions, sampling algorithms and flexible docking studies that hamper the docking successes. Information about the different kin

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GULOTTA, Maria Rita. "Computational methodologies applied to Protein-Protein Interactions for molecular insights in Medicinal Chemistry." Doctoral thesis, Università degli Studi di Palermo, 2021. http://hdl.handle.net/10447/479127.

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In living systems, proteins usually team up into “molecular machinery” implementing several protein-to-protein physical contacts – or protein-protein interactions (PPIs) – to exert biological effects at both cellular and systems levels. Deregulations of protein-protein contacts have been associated with a huge number of diseases in a wide range of medical areas, such as oncology, cancer immunotherapy, infectious diseases, neurological disorders, heart failure, inflammation and oxidative stress. PPIs are very complex and usually characterised by specific shape, size and complementarity. The pr

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Pan, Wenhui. "Isolation, identification, bioactivity evaluation and structure-activity relationship studies of tricothecenes and the miliusa constituents." HKBU Institutional Repository, 2018. https://repository.hkbu.edu.hk/etd_oa/547.

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Background: Natural products have attracted high attention due to their great contribution in drug discovery. Many natural products have shown to be effectively against different disease targets including cancer, malaria and HIV. And their structural diversity is a rich resource for the discovery of novel bioactive compounds. This thesis is to explore plant natural products for their potential in treatment of malaria and cancer diseases. Malaria is still considered as a major global health problem, affecting a large population of the world, especially in the developing countries. Effective dru

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Egbichi, Ifeanyi M. "An investigation into the bioactivity of Sutherlandia frutescens (Cancer bush)." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1777.

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Thesis (MSc (Biochemistry))--University of Stellenbosch, 2009.<br>Sutherlandia frutescens (S. frutescens), sub-species microphylla, is a member of the Fabacea family and is used as a herbal remedy for the treatment of several ailments which include influenza, diabetes, cancer, tuberculosis, chronic fatigue syndrome, rheumatoid arthritis, anxiety, clinical depression, and more recently, those living with human immunodeficiency virus/ acquired immune deficiency syndrome (HIV/AIDS) (1-4). Many of the symptoms of these ailments are associated with a perturbation of the stress response which m

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