Academic literature on the topic 'CANCER-ASSOCIATED MICROBE'

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Journal articles on the topic "CANCER-ASSOCIATED MICROBE"

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Gnanasekar, Aditi, Neil Shende, Jaideep Chakladar, et al. "Abstract 3528: Influence of obesity-associated intra-tumor microbes on exacerbating cancer severity." Cancer Research 82, no. 12_Supplement (2022): 3528. http://dx.doi.org/10.1158/1538-7445.am2022-3528.

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Abstract Background: Despite there being a well-established connection between the gut microbiome and metabolic disease in humans, intra-tumor microbes and the mechanisms by which they regulate cell signaling, inflammation, and adipocyte growth to exacerbate disease severity in cancer patients also suffering from obesity remains largely unclear. In this study, we identified microbes to be distinctly abundant in cancer patients who are obese and correlated microbe abundance to patient survival, clinical variables, and immunological genes and pathways, in order to mechanistically explain how dif
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Bose, Mukulika, and Pinku Mukherjee. "Microbe–MUC1 Crosstalk in Cancer-Associated Infections." Trends in Molecular Medicine 26, no. 3 (2020): 324–36. http://dx.doi.org/10.1016/j.molmed.2019.10.003.

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Li, Wei Tse, Anjali S. Iyangar, Rohan Reddy, et al. "The Bladder Microbiome Is Associated with Epithelial–Mesenchymal Transition in Muscle Invasive Urothelial Bladder Carcinoma." Cancers 13, no. 15 (2021): 3649. http://dx.doi.org/10.3390/cancers13153649.

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The intra-tumor microbiome has recently been linked to epithelial–mesenchymal transition (EMT) in a number of cancers. However, the relationship between EMT and microbes in bladder cancer has not been explored. In this study, we profiled the abundance of individual microbe species in the tumor samples of over 400 muscle invasive bladder carcinoma (MIBC) patients. We then correlated microbe abundance to the expression of EMT-associated genes and genes in the extracellular matrix (ECM), which are key players in EMT. We discovered that a variety of microbes, including E. coli, butyrate-producing
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Malik, Hafiza Iqra, and Muhammad Imran Qadir. "Relation between Gut Microbiota and Cancer." JOURNAL OF MICROBIOLOGY AND MOLECULAR GENETICS 2, no. 1 (2021): 45–54. http://dx.doi.org/10.52700/jmmg.v2i1.28.

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Human has about 100 trillion symbiotic microbes in the gut with 300-1000 different species. Gut microbiota is associated with host metabolism, obesity, diabetes, hepatic disorder, and cancer. Nowadays, studies are focusing on the role of gut microbiota in cancer. Evidence shows that Fusobacterium is associated with colorectal cancer when its genome was confirmed by 16SRNA analysis and PCR technique in cancerous cell. The complete mechanism of gut microbe involvement in cancer is still unknown. There may be some association of toxic metabolites of gut microbes, dietary substances, and the immun
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Sayed, Ibrahim M., Anirban Chakraborty, Amer Ali Abd El-Hafeez, et al. "The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells." Cells 9, no. 9 (2020): 1980. http://dx.doi.org/10.3390/cells9091980.

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Colorectal cancer (CRC) is the third most prevalent cancer, while the majority (80–85%) of CRCs are sporadic and are microsatellite stable (MSS), and approximately 15–20% of them display microsatellite instability (MSI). Infection and chronic inflammation are known to induce DNA damage in host tissues and can lead to oncogenic transformation of cells, but the role of DNA repair proteins in microbe-associated CRCs remains unknown. Using CRC-associated microbes such as Fusobacterium nucleatum (Fn) in a coculture with murine and human enteroid-derived monolayers (EDMs), here, we show that, among
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Ponath, Falk, Caroline Tawk, Yan Zhu, Lars Barquist, Franziska Faber, and Jörg Vogel. "RNA landscape of the emerging cancer-associated microbe Fusobacterium nucleatum." Nature Microbiology 6, no. 8 (2021): 1007–20. http://dx.doi.org/10.1038/s41564-021-00927-7.

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Uzelac, Matthew, Wei Tse Li, Jaideep Chakladar, Daniel John, and Weg M. Ongkeko. "Abstract LB110: Racial and ethnic disparities associated with the intratumor microbiome in female cancers." Cancer Research 83, no. 8_Supplement (2023): LB110. http://dx.doi.org/10.1158/1538-7445.am2023-lb110.

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Abstract Background: The intratumor microbiome is implicated in tumor initiation, progression, and altered immune response to cancer therapies. Furthermore, recent studies have revealed correlations between microbial abundance and racial disparities in cancer. While these investigations provide novel insights into cancer disparities research, few have investigated which racial and ethnic disparities exist for patients with female malignancies. In this study, we characterized the intratumor microbiome according to racial and ethnic disparities in common female malignancies including breast, cer
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Armstrong, Heather, Michael Bording-Jorgensen, Stephanie Dijk, and Eytan Wine. "The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It." Cancers 10, no. 3 (2018): 83. http://dx.doi.org/10.3390/cancers10030083.

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Cancer is a multifaceted condition, in which a senescent cell begins dividing in an irregular manner due to various factors such as DNA damage, growth factors and inflammation. Inflammation is not typically discussed as carcinogenic; however, a significant percentage of cancers arise from chronic microbial infections and damage brought on by chronic inflammation. A hallmark cancer-inducing microbe is Helicobacter pylori and its causation of peptic ulcers and potentially gastric cancer. This review discusses the recent developments in understanding microbes in health and disease and their poten
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Wang, Di, Yan Cui, Yuxuan Cao, Yuehan He, and Hui Chen. "Human Microbe-Disease Association Prediction by a Novel Double-Ended Random Walk with Restart." BioMed Research International 2020 (August 11, 2020): 1–8. http://dx.doi.org/10.1155/2020/3978702.

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Microorganisms in the human body play a vital role in metabolism, immune defense, nutrient absorption, cancer control, and prevention of pathogen colonization. More and more biological and clinical studies have shown that the imbalance of microbial communities is closely related to the occurrence and development of various complex human diseases. Finding potential microbial-disease associations is critical for understanding the pathology of a few diseases and thus further improving disease diagnosis and prognosis. In this study, we proposed a novel computational model to predict disease-associ
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Liu, Yunjie, Yao-zhong Zhang, and Seiya Imoto. "Microbial Gene Ontology informed deep neural network for microbe functionality discovery in human diseases." PLOS ONE 18, no. 8 (2023): e0290307. http://dx.doi.org/10.1371/journal.pone.0290307.

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The human microbiome plays a crucial role in human health and is associated with a number of human diseases. Determining microbiome functional roles in human diseases remains a biological challenge due to the high dimensionality of metagenome gene features. However, existing models were limited in providing biological interpretability, where the functional role of microbes in human diseases is unexplored. Here we propose to utilize a neural network-based model incorporating Gene Ontology (GO) relationship network to discover the microbe functionality in human diseases. We use four benchmark da
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Dissertations / Theses on the topic "CANCER-ASSOCIATED MICROBE"

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HASHMI, RAMSHA. "IN-SILICO STUDY BASED EVIDENCE OF MICROBE DRIVEN MODULATION OF CANCER PROGNOSIS." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18898.

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Cancer has been a major cause of disease burden on humanity for eons with one-fifth of all instances of cancer being connected with microbial prevalence and dysbiosis. There has been an inrush of instances asserting the dual character of human microbiota in maintaining homeostasis and its association with various ailments, including cancer. The diverse microbiota inhabiting the gut constitute a complicated symbiotic relationship conferring benefits to the organisms’ body in numerous ways, such as aiding metabolism, immunity, and nutrition. The microbiome has been seen to be affected by b
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Books on the topic "CANCER-ASSOCIATED MICROBE"

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Wells, Anjanette, Vetta L. Sanders Thompson, Will Ross, Carol Camp Yeakey, and Sheri Notaro. Poverty and Place. The Rowman & Littlefield Publishing Group, 2018. https://doi.org/10.5040/9781978725898.

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This bookexamines ways in which cancer health disparities exist due to class and context inequities even in the most advanced society of the world. This volume, while articulating health disparities in the St. Louis, Missouri metropolitan area, including East St. Louis, Illinois, seeks to move beyond deficit models to focus on health equity. As cancer disparities continue to persist for low-income and women of color, the promotion and attainment of health equity becomes a matter of paramount importance. The volume demonstrates the importance of place and the historical inequity in socio-enviro
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Book chapters on the topic "CANCER-ASSOCIATED MICROBE"

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Fehri, Emna, Emna Ennaifer, Monia Ardhaoui, Haifa Tounsi, Rahima Bel Haj Rhouma, and Samir Boubaker. "TLR AND CANCER: THE ENIGMATIC CROSS TALK." In Thirty Years since the Discovery of Toll-Like Receptors. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.1004101.

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The connection between inflammation and cancer has been well recognized at the epidemiological, biological, and pharmacological levels. Unresolved chronic inflammation is implicated in most stages of cancer development and thus can induce certain solid tumors. The molecular regulators of these linkages are emerging and should be well-decorticated. Toll-like receptors (TLRs) recognize pathogen/microbe-associated molecular patterns (PAMPs/MAMPs) and death–associated molecular patterns (DAMPs) secreted from dying or damaged cells of the host. TLRs can be pro and anti-tumorigenic depending on the
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Yaro, Prof Abubakar, Dr Catherine Johnson, and Dr Pranab Kumar Bhattacharya. "EPSTEIN BARR VIRUS (EBV)-ASSOCIATED CANCER BIOMARKERS FOR DIAGNOSIS, PROGNOSIS AND THERAPY: NARRATIVE REVIEW." In Microbes of Medical Importance. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/nbennurmmch9.

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Oncoviruses are viruses that cause different cancers. To enable them survive, these viruses have evolved strategies that have direct or indirect carcinogenic effect by either encoding viral oncogenes which plays a role in the transformation of cells or causing persistent infection which results in chronic inflammation with significant tumorigenic effect. In most cases, virus do not directly initiate the Oncogenic process but plays a role in the acquisition of the risk factors that are linked with the development of cancer (Fig 1) over many years because the process of cancer development involv
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Gilbert, Brent, and Taryn Naidoo. "Urobiome and Bladder Cancer." In Update on Bladder Cancer. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.107515.

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Microbiome studies, fueled by the availability of high-throughput DNA-based techniques, have shown that microbiome alterations is associated with human disease including cancer. Traditionally, bladder epithelium and urine have been considered sterile in healthy individuals. This was based primarily on microbiological urine cultures, best suited for detecting aerobic, fast-growing uropathogens. Microbiome and new culturing techniques have shown that urine is not sterile but contains distinct commensal microorganisms and that alterations in commensal bladder microbes is associated with bladder c
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Mane, Vinuta, Suresh B. Arakera, Shubhangi Pingle, and Lucky Thakkar. "Lectin as an Anticancer Therapeutic Agent." In Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-9258-8.ch017.

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Every year nearly 9.6 million people die from cancer worldwide. One third of cancer deaths are due to behavioural and dietary risks and lack of physical activity. Lectins are powerful oral and parental immunogens and some of their physiological effects are intricately linked to interference with immune function. Lectins are produced by wide range of living organisms from microbes to mammals. They function as both allergens and heamagglutinins. Various lectins have been identified which are associated with different types of cancers. Because of this property, they are currently employed as ther
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Vijendra, Poornima D., Pratap G. K., Kumar Vadlapudi, and Manjula S. "Natural Products for Treating Colorectal Cancer." In Handbook of Research on Natural Products and Their Bioactive Compounds as Cancer Therapeutics. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-9258-8.ch005.

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Colorectal cancer (CRC) is one of the causes of cancer-related mortalities across the globe. Epidemiological studies reveal the risk factors for CRC are genetic and environmental factors. The current therapeutic methods for CRC are associated with side effects and drug resistance. Gut microbiome therapy is one of the recent approaches for the prevention of CRC, reducing its progression and improving the effectiveness of colorectal cancer treatment by modulating the gut microbiome. The use of phytoconstituents is another approach. These compounds increase the gene expression of the cell cycle i
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Singh, Shilpi, Bindu Kumari, Sonal Sinha, Gireesh Kumar Singh, Suaib Lqman, and Dhananjay Kumar Singh. "Probiotics Based Anticancer Immunity In Stomach Cancer." In Probiotics in Anticancer Immunity. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815124781123030010.

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Stomach cancer is a global health challenge due to its increasing prevalence. The intestinal microbiota of humans plays a vital role in producing short-chain fatty acids, developing resistance towards pathogenic microbes, nutrient absorption, modulation in immunological response, metabolism, synthesis of vitamins, and gut immune system development. Many diseases or disorders, including cancers, obesity, psychiatric illnesses, rheumatoid arthritis, and inflammatory bowel syndrome, are associated with an imbalance of microbiotas. Earlier reports suggest that probiotics via the oral route act as
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Riddell, Anna, and C. Y. William Tong. "Gastro-intestinal, Hepatic, Pancreatic, and Biliary Infections." In Tutorial Topics in Infection for the Combined Infection Training Programme. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198801740.003.0041.

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The gastro-intestinal tract (GIT) hosts the most numerous and diverse reservoir of microbes in humans. There is increasing interest in the relationship between the GIT microbiome and human health. Obesity, diabetes, allergy, and a number of inflammatory diseases have been linked with the human GIT microbiome. Infections of the GIT arise either as a result of a change in the relationship between the commensal microbes colonizing the GIT (endogenous infection) or entry in to the GIT of a micro-organism which causes disease (exogenous infection). Commensals most commonly invade host tissues as a
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Lehtinen, Matti. "Etiological Studies on Cervical Neoplasia – A Showcase of Causal Inferencing." In Human Papillomavirus Vaccination and Screening in the Elimination of HPV-Associated Cancers: Evidence-Based Randomized Trials. BENTHAM SCIENCE PUBLISHERS, 2024. https://doi.org/10.2174/9789815305487124010003.

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Preventive medicine is largely about identification of causes of diseases and their removal. Cervical cancer in Finland is firstly a showcase and secondly a use-case of preventive medicine. Firstly, etiological studies on cervical cancer were for long confounded by the fact that sexually transmitted infections are surrogates of both risktaking behaviour in adolescent and young adult population, and occurrence of cervical cancer in middle-aged women. Identifying oncogenic human papillomaviruses (HPVs) as the true cause of cervical cancer among the multitude of different sexually transmitted mic
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Ali, Muhammad Shahbaz, Hammad Naeem, Shamas Murtaza, Nighat Raza, and Umar Farooq. "Probiotic Bacteria and Plants." In Medicinal Plants: Microbial Interactions, Molecular Techniques and Therapeutic Trends. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815136838123010009.

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Probiotics are microorganisms, when consumed, give health benefits due to improvement in the activity of gut microflora. Various health claims are associated with probiotics e.g. modulation of the immune system, mitigation of lactose intolerance, protection from infections and maintenance of healthy gut microflora. They have also been demonstrated to be helpful in treating a wide range of illnesses, including cancer, inflammatory bowel syndrome, diarrhea brought on by antibiotics, and infantile diarrhea. Streptococcus, Bacillus, Enterococcus, Escherichia coli, Bifidobacterium, Lactobacillus, a
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Annapoorani, Angusamy, Arumugam Veera Ravi, Sundaram Janarthanan, and Kandasamy Kathiresan. "Antimicrobials from Mangroves." In Frontiers in Antimicrobial Agents. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815080148123030010.

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Mangroves are a promising source of antimicrobials owing to the bioavailability of genes, plant metabolites and biological diversity. Mangroves are known for their many biological properties, such as antibacterial, antifungal, antiviral and anti-cancer activities etc. Besides mangroves, the microbes associated with mangroves are called endophytes, which are proven effective antimicrobials and are also well-known for their many other pharmacological properties. Mangrove extracts coated with nanoparticles exhibit better antimicrobial activity due to their easy absorption and distribution propert
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Conference papers on the topic "CANCER-ASSOCIATED MICROBE"

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Ternes, Dominik, Martine Schmitz, Léa Grandmougin, et al. "Abstract A09: Understanding the role of colorectal cancer-associated microbes in colorectal cancer." In Abstracts: AACR Special Conference on the Microbiome, Viruses, and Cancer; February 21-24, 2020; Orlando, FL. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.mvc2020-a09.

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Attaluri, Anilchandra, Ronghui Ma, and Liang Zhu. "Using MicroCT Imaging to Quantify Heat Generation Distribution Induced by Magnetic Nanoparticles." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19033.

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In the past decade, there have been renewed interests in using magnetic nanoparticles as heating agents when subjected to an alternating magnetic field in cancer treatments. Due to the technical advancement in manufacturing nano-sized magnetic particles, nanoparticle hyperthermia has emerged as an attractive alternative to costly and risky surgical procedures because of its few associated complications and targeted delivery of thermal energy to the tumor.
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Nolte, David, Shadia Jalal, and Ran An. "Twin-Neural-Network Differential Autoencoder and Dynamic-Contrast Optical Coherence Tomography for Cancer Diagnostics." In CLEO: Applications and Technology. Optica Publishing Group, 2022. http://dx.doi.org/10.1364/cleo_at.2022.am5i.6.

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Dynamic-contrast optical coherence tomography (OCT) using en face digital holography senses intracellular dynamics in living tumor tissue. Intracellular motions produce ultra-low-frequency Doppler shifts for speeds down to nanometers per second (10 mHz) and up to microns per second (10 Hz). Cancer drugs applied to human tumor biopsies induce changes in these dynamics and produce specific Doppler signatures of therapeutic efficacy. We have developed a new type of deep neural network that performs as a differential autoencoder with high common-mode rejection that isolates Doppler signatures asso
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Choi, Sae Rome, Hye-ran Moon, Natalia Ospina, et al. "DRUG-DISCOVERY-ON-CHIP: DISCOVERY AND VALIDATION OF TARGETS IN PANCREATIC CANCER USING MICROFLUIDIC PANCREATIC CANCER-ASSOCIATED COAGULATION MODELS." In The 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems. Chemical and Biological Microsystems Society, 2024. https://doi.org/10.70477/kdid3348.

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