Relevant bibliographies by topics / Cancer cell microenvironment

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Cancer cell microenvironment'

Author: Grafiati
Published: 2 November 2024
Last updated: 31 July 2025

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Journal articles on the topic "Cancer cell microenvironment"

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Campbell, Caroline J., and Brian W. Booth. "The Influence of the Normal Mammary Microenvironment on Breast Cancer Cells." Cancers 15, no. 3 (2023): 576. http://dx.doi.org/10.3390/cancers15030576.

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The tumor microenvironment is recognized as performing a critical role in tumor initiation, progression, and metastasis of many cancers, including breast cancer. The breast cancer microenvironment is a complex mixture of cells consisting of tumor cells, immune cells, fibroblasts, and vascular cells, as well as noncellular components, such as extracellular matrix and soluble products. The interactions between the tumor cells and the tumor microenvironment modulate tumor behavior and affect the responses of cancer patients to therapies. The interactions between tumor cells and the surrounding en
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Shive, Heather R., John S. House, Jordan L. Ferguson, Dereje D. Jima, Aubrie A. Selmek, and Dillon T. Lloyd. "Abstract PR011: Characterization of the precancerous and cancer microenvironment in a zebrafish sarcoma model." Clinical Cancer Research 28, no. 18_Supplement (2022): PR011. http://dx.doi.org/10.1158/1557-3265.sarcomas22-pr011.

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Abstract Contributions of the microenvironment to soft tissue sarcoma progression are relatively undefined, representing a major impediment to identifying essential regulatory networks in sarcomagenesis. Furthermore, genetic and molecular characteristics that distinguish precancerous versus cancerous microenvironments are not well known across human cancer types. While animal models have the potential to reveal these complex processes, significant impediments to such inquiries include (1) the difficulty in distinguishing microenvironmental cells from precancerous or cancer cells in tissue spec
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Gibson, Spencer, Tricia Choquette, Elizabeth S. Henson, Xioyan Yang, and James B. Johnston. "Abstract 2516: Analysis of CLL Celllular Environment and Response (ACCER) is a novel method to understand the microenvironment in CLL." Cancer Research 83, no. 7_Supplement (2023): 2516. http://dx.doi.org/10.1158/1538-7445.am2023-2516.

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Abstract Microenvironments such as lymph nodes and bone marrow allow chronic lymphocytic leukemia (CLL) cells to survive after drug treatments. There are limited methods to study the to study the contribution of the microenvironment. We have adapted a solid tumour microenvironment cell culture system that provides elements of the CLL microenvironment called Analysis of CLL Cellular Environment and Response (ACCER). We optimized the cell number for patient’s primary CLL cells and HS-5 human bone marrow stromal cell line that will give sufficient cell number and viability with the ACCER. We then
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Bischoff, Philip, Alexandra Trinks, Benedikt Obermayer, et al. "Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma." Oncogene 40, no. 50 (2021): 6748–58. http://dx.doi.org/10.1038/s41388-021-02054-3.

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AbstractRecent developments in immuno-oncology demonstrate that not only cancer cells, but also the tumor microenvironment can guide precision medicine. A comprehensive and in-depth characterization of the tumor microenvironment is challenging since its cell populations are diverse and can be important even if scarce. To identify clinically relevant microenvironmental and cancer features, we applied single-cell RNA sequencing to ten human lung adenocarcinomas and ten normal control tissues. Our analyses revealed heterogeneous carcinoma cell transcriptomes reflecting histological grade and onco
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Aber, Etan R., Cristina F. Contreras, Mohd Omar Sikder, et al. "Abstract LB308: Transcriptional profiling uncovers a unified program underlying the human metastatic and adjacent microenvironments." Cancer Research 84, no. 7_Supplement (2024): LB308. http://dx.doi.org/10.1158/1538-7445.am2024-lb308.

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Abstract Metastasis is the primary cause of death in patients with solid tumors, yet the treatment-refractory metastatic microenvironment is poorly characterized. To gain a comprehensive understanding of microenvironmental regulation of human metastasis, we performed single-cell RNA sequencing covering endothelial, stromal, myeloid, lymphoid, and malignant cells from 28 lung and liver samples of the metastatic microenvironment and metastasis-free adjacent microenvironment from patients with metastatic adrenocortical carcinoma compared to healthy donors for a total of 275,903 cells. We discover
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Feng, Yinghua, Xiuli Zhang, Guangpeng Wang, et al. "Comprehensive Integrated Analysis Reveals the Spatiotemporal Microevolution of Cancer Cells in Patients with Bone-Metastatic Prostate Cancer." Biomedicines 13, no. 4 (2025): 909. https://doi.org/10.3390/biomedicines13040909.

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Background/Objectives: Bone metastasis is a frequent and life-threatening event in advanced cancers, affecting up to 70–85% of prostate cancer patients. Understanding the cellular and molecular mechanisms underlying bone metastasis is essential for developing targeted therapies. This study aimed to systematically characterize the heterogeneity and microenvironmental adaptation of prostate cancer bone metastases using single-cell transcriptomics. Methods: We integrated the largest single-cell transcriptome dataset to date, encompassing 124 samples from primary prostate tumors, various bone meta
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AbdelFattah, HebatAllah Samy, Mayar Tarek Ibrahim, Mostafa Mahmoud Nasr, and Shaimaa Nasr Nasr Amin. "Cell Signaling in Cancer Microenvironment." International Journal of Advanced Biomedicine 2, no. 2 (2017): 47–51. http://dx.doi.org/10.18576/ab/020204.

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Loberg, Robert D., Christopher J. Logothetis, Evan T. Keller, and Kenneth J. Pienta. "Pathogenesis and Treatment of Prostate Cancer Bone Metastases: Targeting the Lethal Phenotype." Journal of Clinical Oncology 23, no. 32 (2005): 8232–41. http://dx.doi.org/10.1200/jco.2005.03.0841.

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Traditionally, prostate cancer treatment, as well as all cancer treatment, has been designed to target the tumor cell directly via various hormonal and chemotherapeutic agents. Recently, the realization that cancer cells exist in complex microenvironments that are essential for the tumorigenic and metastatic potential of the cancer cells is starting the redefine the paradigm for cancer therapy. The propensity of prostate cancer cells to metastasize to bone is leading to the design of novel therapies targeting both the cancer cell as well as the bone microenvironment. Tumor cells in the bone in
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Garre, Elena, Anna Gustafsson, Maria Carmen Leiva, et al. "Breast Cancer Patient-Derived Scaffolds Can Expose Unique Individual Cancer Progressing Properties of the Cancer Microenvironment Associated with Clinical Characteristics." Cancers 14, no. 9 (2022): 2172. http://dx.doi.org/10.3390/cancers14092172.

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Breast cancer is a heterogeneous disease in terms of cellular and structural composition, and besides acquired aggressive properties in the cancer cell population, the surrounding tumor microenvironment can affect disease progression and clinical behaviours. To specifically decode the clinical relevance of the cancer promoting effects of individual tumor microenvironments, we performed a comprehensive test of 110 breast cancer samples using a recently established in vivo-like 3D cell culture platform based on patient-derived scaffolds (PDSs). Cell-free PDSs were recellularized with three breas
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Kim, Jaehong. "Regulation of Immune Cell Functions by Metabolic Reprogramming." Journal of Immunology Research 2018 (2018): 1–12. http://dx.doi.org/10.1155/2018/8605471.

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Recent findings show that the metabolic status of immune cells can determine immune responses. Metabolic reprogramming between aerobic glycolysis and oxidative phosphorylation, previously speculated as exclusively observable in cancer cells, exists in various types of immune and stromal cells in many different pathological conditions other than cancer. The microenvironments of cancer, obese adipose, and wound-repairing tissues share common features of inflammatory reactions. In addition, the metabolic changes in macrophages and T cells are now regarded as crucial for the functional plasticity
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Dissertations / Theses on the topic "Cancer cell microenvironment"

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YOUSAFZAI, MUHAMMAD SULAIMAN. "Cancer cell mechanics and cell microenvironment: An optical tweezers study." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908097.

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Since cancer metastasis is a complex process, lot of research has been carried out to identify different hallmarks for its diagnosis and cure. Mechanical alterations in cancer cells during cell spreading to adjacent tissues and other organs of the body emerged as a prominent hallmark in the last decade. In this thesis we employed a mechanistic approach and used stiffness (elasticity) as a marker to study cell’s mechanical response in varying microenvironmental conditions. Cell– microenvironment mechanical interaction is a blend of cell-matrix and cell-cell interactions. Therefore we adopted
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Hodkinson, Philip Simon. "Tumour microenvironment interactions of small cell lung cancer." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4254.

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Small cell lung cancer (SCLC) is characterised by rapid growth, early metastatic spread and poor long-term survival. The tumour is initially sensitive to chemotherapy and thus objective response rates are high. Unfortunately, this response is often short-lived and SCLC recurs with acquired drug resistance, resulting in early patient death. Despite intensive chemo- and radiotherapy regimes survival has not improved significantly in 20 years. Prior research suggests a critical role for the tumour microenvironment in the pathogenesis of other cancers. Therefore, investigating interactions between
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Fong, Jenna. "Breast cancer cells affect bone cell differentiation and the bone microenvironment." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104758.

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Breast carcinoma is the most commonly diagnosed cancer among women worldwide, with approximately 1 in 7 expected to be affected during her lifetime. The spread of breast cancer to secondary sites is generally incurable. Bone is the preferred site of metastasis, where the development of a secondary tumour causes severe osteolysis, hypercalcemia and a considerable pain burden. However, how breast cancer cells establish supportive interactions with bone cells is not well understood. We have examined the effects of factors released from MDA-MB-231 and 4T1 breast cancer cells on the differentiation
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Daukšte, Liene. "Mathematical Modelling of Cancer Cell Population Dynamics." Thesis, University of Canterbury. Mathematics and Statistics, 2012. http://hdl.handle.net/10092/9356.

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Mathematical models, that depict the dynamics of a cancer cell population growing out of the human body (in vitro) in unconstrained microenvironment conditions, are considered in this thesis. Cancer cells in vitro grow and divide much faster than cancer cells in the human body, therefore, the effects of various cancer treatments applied to them can be identified much faster. These cell populations, when not exposed to any cancer treatment, exhibit exponential growth that we refer to as the balanced exponential growth (BEG) state. This observation has led to several effective methods of estimat
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Truong, Danh, Julieann Puleo, Alison Llave, Ghassan Mouneimne, Roger D. Kamm, and Mehdi Nikkhah. "Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment." NATURE PUBLISHING GROUP, 2016. http://hdl.handle.net/10150/621806.

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In this study, to model 3D chemotactic tumor-stroma invasion in vitro, we developed an innovative microfluidic chip allowing side-by-side positioning of 3D hydrogel-based matrices. We were able to (1) create a dual matrix architecture that extended in a continuous manner, thus allowing invasion from one 3D matrix to another, and (2) establish distinct regions of tumor and stroma cell/ECM compositions, with a clearly demarcated tumor invasion front, thus allowing us to quantitatively analyze progression of cancer cells into the stroma at a tissue or single-cell level. We showed significantly en
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Giraldo-Castillo, Nicolas. "The Immune Microenvironment in Clear Cell Renal Cell Carcinoma : The heterogeneous immune contextures accompanying CD8+ T cell infiltration in clear cell Renal Cell Carcinoma." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066321/document.

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Dans cette étude, nous avons tenté de décrypter les mécanismes reliant l’augmentation de lymphocytes infiltrant les tumeurs (LIT) T CD8+ et un pronostic clinique défavorable dans le cancer du rein à cellules claires (ccRCC). Pour cela, nous avons déterminé 1) la relation entre le pronostic associé à l'expression d’immune checkpoints et l’infiltrat de cellules dendritiques (DC) et de LT CD8+ et 2) les caractéristiques phénotypiques des LIT T CD8+. L’expression des immune checkpoints a été déterminée par immunohistochimie dans une cohorte de 135 ccRCC. Nous avons constaté que les densités des ce
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Kaira, Mustapha. "In situ molecular profilling of the microenvironment of breast carcinoma." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-265258.

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High stromal PDGF receptor B expression was shown to have strong prognostic value in a studyinvolving over 600 breast cancer patients however, the molecular role of the receptor in tumordevelopment remains unclear. In this project we studied the spatial distribution and expressionlevels of a panel genes and markers associated with PDGF signaling, in breast cancer tumormicroenvironment (TME) using a newly developed technique -in situ sequencing. The techniquerelies on padlock probes which we validated with corresponding RNA sequencing, microarray,and immunohistochemistry data. Our results showe
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Xing, Fei. "ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS." OpenSIUC, 2012. https://opensiuc.lib.siu.edu/dissertations/514.

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Notch signaling is often and aberrantly activated by hypoxia during tumor progression; however, the exact pathological role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In the first part of this study, we aimed to define the mechanism of Notch ligand activation by hypoxia in both primary tumor and bone stromal cells in the metastatic niche and to clarify their roles in tumor progression. We have analyzed the expression profiles of various Notch liagnds in 779 breast cancer patients in GEO database and found that the expression of Jagged2 among all five
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Kiyasu, Yoshiyuki. "Disruption of CCR1-mediated myeloid cell accumulation suppresses colorectal cancer progression in mice." Kyoto University, 2020. http://hdl.handle.net/2433/259008.

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Sundquist, E. (Elias). "The role of tumor microenvironment on oral tongue cancer invasion and prognosis." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526217659.

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Abstract Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity. The 5-year mortality of OTSCC remains at about 50%. The tumor microenvironment (TME) is now recognized as an important factor in cancer progression and metastasis, as well as a tool for prognostication. The aim of this study was to elucidate the roles of TME hypoxia and soluble factors on cancer cell migration and invasion, and the prognostic value of two extracellular matrix (ECM) molecules: tenascin-C (TNC) and fibronectin (FN). Hypoxia was studied using oral squamous cell carcinoma cells in mi
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Books on the topic "Cancer cell microenvironment"

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Prasad, Mayuri Sinha, Pranela Rameshwar, and Cristian Pablo Pennisi. The Stem Cell Microenvironment and Its Role in Regenerative Medicine and Cancer Pathogenesis. River Publishers, 2022. http://dx.doi.org/10.1201/9781003339779.

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Jamie, Goode, Chadwick Derek, Novartis Foundation, and Symposium on the Tumour Microenvironment: Causes and Consequences of Hypoxia and Acidity (2000 : London, England), eds. The tumour microenvironment: Causes and consequences of hypoxia and acidity. Wiley, 2001.

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Gianfranco, Fiorentini, Cogle Christopher R, and SpringerLink (Online service), eds. Cancer Microenvironment and Therapeutic Implications: Tumor Pathophysiology Mechanisms and Therapeutic Strategies. Springer Netherlands, 2009.

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Siemann, Dietmar W. Tumor Microenvironment. Wiley & Sons, Incorporated, John, 2011.

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Siemann, Dietmar W. Tumor Microenvironment. Wiley & Sons, Incorporated, John, 2011.

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Siemann, Dietmar W. Tumor Microenvironment. Wiley & Sons, Incorporated, John, 2010.

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Tumor microenvironment. Wiley, 2011.

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Physics of Cancer. Cambridge University Press, 2017.

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Zapperi, Stefano, and Caterina A. M. La Porta. Physics of Cancer. Cambridge University Press, 2017.

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Zapperi, Stefano, and Caterina A. M. La Porta. Physics of Cancer. Cambridge University Press, 2017.

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Book chapters on the topic "Cancer cell microenvironment"

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Zucker, Stanley, and Jian Cao. "Matrix Metalloproteinases and Cancer Cell Invasion/Metastasis." In The Tumor Microenvironment. Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6615-5_25.

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Enders, Greg H. "Ink4a Locus: Beyond Cell Cycle." In Cancer Genome and Tumor Microenvironment. Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0711-0_10.

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Sazeides, Christos, and Anne Le. "Metabolic Relationship Between Cancer-Associated Fibroblasts and Cancer Cells." In The Heterogeneity of Cancer Metabolism. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65768-0_14.

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AbstractCancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME), play an important role in cancer initiation, progression, and metastasis. Recent findings have demonstrated that the TME not only provides physical support for cancer cells but also directs cell-to-cell interactions (in this case, the interaction between cancer cells and CAFs). As cancer progresses, the CAFs also coevolve, transitioning from an inactivated state to an activated state. The elucidation and understanding of the interaction between cancer cells and CAFs will pave the way for new ca
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Ray, Suman Kumar, and Sukhes Mukherjee. "Hypoxia and Regulation of Cancer Cell Stemness." In Hypoxia and Tumor Microenvironment. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-96-1016-7_8.

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Jung, Jin G., and Anne Le. "Metabolism of Immune Cells in the Tumor Microenvironment." In The Heterogeneity of Cancer Metabolism. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65768-0_13.

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AbstractThe tumor microenvironment (TME) is a complex biological structure surrounding tumor cells and includes blood vessels, immune cells, fibroblasts, adipocytes, and extracellular matrix (ECM) [1, 2]. These heterogeneous surrounding structures provide nutrients, metabolites, and signaling molecules to provide a cancer-friendly environment. The metabolic interplay between immune cells and cancer cells in the TME is a key feature not only for understanding tumor biology but also for discovering cancer cells’ vulnerability. As cancer immunotherapy to treat cancer patients and the use of metab
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Bennani, N. Nora, and Stephen M. Ansell. "Tumor Microenvironment in T-Cell Lymphomas." In Cancer Treatment and Research. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-99716-2_3.

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Alvarez-Silva, Marcio. "Stem Cell Niche and Microenvironment." In Principles of Stem Cell Biology and Cancer. John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118670613.ch3.

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Khamaru, Somlata, Kshyama Subhadarsini Tung, and Subhasis Chattopadhyay. "Cellular Immune Responses in Tumor Microenvironment." In Cell-based Immunotherapies for Cancer. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-88695-9_1.

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Wilke, Cailin Moira, Shuang Wei, Lin Wang, et al. "T Cell and Antigen-Presenting Cell Subsets in the Tumor Microenvironment." In Cancer Immunotherapy. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-4732-0_2.

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Colombatti, Alfonso, Carla Danussi, Eliana Pivetta, and Paola Spessotto. "Cancer Stem Cells and the Microenvironment." In Advances in Cancer Stem Cell Biology. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4614-0809-3_5.

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Conference papers on the topic "Cancer cell microenvironment"

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Zhao, Yujie, Sarah S. L. Chow, Robert Serafin, Elena Baraznenok, and Jonathan T. C. Liu. "Elucidating the 3D Tissue Microenvironment via Graph Neural Networks for Cancer Risk Stratification." In Bio-Optics: Design and Application. Optica Publishing Group, 2025. https://doi.org/10.1364/boda.2025.jm4a.14.

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We propose a weakly supervised graph neural network workflow that integrates 3D histological features including cell-cell interactions for risk stratification. This framework will be developed and evaluated using 3D pathology datasets of prostate cancer.
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Kim, Taeyeon, Jisung Kwak, Yeeun Roh, Sang Jun Sim, Hyun Seok Song, and Minah Seo. "Spectroscopic Analysis of Live Cancer Cell Microenvironment with Terahertz Metasurface Biosensing Platform." In 2024 49th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz). IEEE, 2024. http://dx.doi.org/10.1109/irmmw-thz60956.2024.10697664.

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Langley, Andrew, Allison Sweeney, Christopher Nguyen, Skye Edwards, Deeksha Sankepalle, and Srivalleesha Mallidi. "Non-invasive simultaneous assessment of therapy-induced tumor microenvironmental changes in collagen and vasculature with photoacoustic imaging." In Optical Molecular Probes, Imaging and Drug Delivery. Optica Publishing Group, 2025. https://doi.org/10.1364/omp.2025.om5e.2.

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The tumor microenvironment (TME) is critical for tumor cell survival and metastasis, comprising both cellular (immune and stromal cells) and non-cellular (extracellular matrix, ECM) components. Collagen within the ECM, produced by cancer-associated fibroblasts, fosters aggressive tumor phenotypes and confers resistance to chemotherapy. To enhance the efficacy of cancer therapies, various innovative strategies are being developed to normalize or target tumor collagen. We have previously demonstrated that photodynamic therapy (PDT) at low doses, termed photodynamic priming (PDP), can degrade col
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Gileva, M. S., E. G. Ufimceva, L. F. Gulyaeva, and V. V. Kozlov. "EX VIVO CHARACTERISTICS OF NON-SMALL CELL LUNG CANCER CELLS." In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-308.

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The search for molecular markers for the identification of adenocarcinoma and squamous cell lung cancer remains an urgent problem. In this work, for the first time, an ex vivo method was used to isolate cells from tissue samples of patients with non-small cell lung cancer. Potential markers of this histological tumor type were analyzed, and the cellular composition of the immune microenvironment was also assessed, including depending on the smoking status of patients.
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Dereli-Korkut, Zeynep, and Sihong Wang. "Microfluidic Cell Arrays to Mimic 3D Tissue Microenvironment." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80411.

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We developed a functional high throughput 3D microfluidic living cell array (MLC) for anti-cancer drug screening and mechanism discovery. Contemporary drug screening methods suffer from low sample throughput and lack of abilities of mimicking the 3D microenvironment of mammalian tissues. The poor performance of anti-cancer drugs limits the efficacy at controlling the complex disease system like cancer. Systematic studies of apoptotic signaling pathways can be prominent approaches for searching active and effective treatments with less drug resistance. Hence, innovative bio-devices are needed t
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Musulin, Jelena, Daniel Štifanić, Ana Zulijani, and Zlatan Car. "SEMANTIC SEGMENTATION OF ORAL SQUAMOUS CELL CARCINOMA ON EPITHELLIAL AND STROMAL TISSUE." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.194m.

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Oral cancer (OC) is among the top ten cancers worlwide, with more than 90% being squamous cell carcinoma. Despite diagnostic and therapeutic development in OC patients’ mortality and morbidity rates remain high with no advancement in the last 50 years. Development of diagnostic tools in identifying pre-cancer lesions and detecting early-stage OC might contribute to minimal invasive treatment/surgery therapy, improving prognosis and survival rates, and maintaining a high quality of life of patients. For this reason, Artificial Intelligence (AI) algorithms are widely used as a computational aid
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Levina, Vera V., Adele Marrangoni, Elieser Gorelik, Robert Edwards, and Anna Lokshin. "Abstract 3408: Ovarian cancer stem cell cytokine microenvironment." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3408.

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Pires, Bruno Ricardo Barreto, Paulo Rohan, Caroline Borges-de-Almeida, Rafael Cardoso Maciel Costa Silva, Renata Binato, and Eliana Abdelhay. "Comprehensive analysis of TWIST1 in breast cancer and other carcinomas: an association with prognosis and tumor microenvironment." In Brazilian Breast Cancer Symposium 2024. Mastology, 2024. http://dx.doi.org/10.29289/259453942024v34s1063.

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Objective: Metastasis is the main cause of death in patients with carcinomas. This process depends on a phenotypic alteration known as epithelial–mesenchymal transition (EMT), regulated by transcription factors (TFs), including TWIST1, whose increased levels have been described in several carcinomas, including breast cancer. However, a comprehensive analysis of its expression to elucidate its predictive value still needs to be performed. This study aimed to understand the prognostic value of TWIST1 expression and its biological relevance for tumor microenvironment (TME) in breast cancer and ot
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Manandhar, Sarala, Chang-gu Kim, Su Young Oh, et al. "Abstract B21: Exostosin 1 regulates cancer cell stemness in breast cancer cells." In Abstracts: AACR Special Conference: The Function of Tumor Microenvironment in Cancer Progression; January 7-10, 2016; San Diego, CA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.tme16-b21.

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Camargo, Luana Cristina, Joao Paulo Figueiro Longo, Karen Letycia Rodrigues de Paiva, Marina Mesquita Simões, Thais Bergmann, and Victor Carlos Mello da Silva. "Immunotherapy vaccines for triple-negative breast cancer and its influence on the tumor microenvironment." In Brazilian Breast Cancer Symposium 2023. Mastology, 2023. http://dx.doi.org/10.29289/259453942023v33s1024.

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Objective: Cancer is still a complex and debilitating disease even though advances in treatment have occurred. Triplenegative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis and occurs more frequently in young women. Due to its metastatic features and unique tumor microenvironment, TNBC treatment is limited. In this study, we evaluated how three chemotherapy drugs could be used to produce vaccines with cells under immunogenic cell death. Methodology: For that, 4T1-luc2 cells were treated with cisplatin (100 μM), mitoxantrone (MTX) (15 μM), and doxorubicin (
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Reports on the topic "Cancer cell microenvironment"

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Gordon, Ryan R. Identification of Cell Nonautonomous DNA Damage Responses in the Tumor Microenvironment that Contribute to Cancer Therapy Resistance. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada577632.

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2

Gordon, Ryan R. Identification of Cell Nonautonomous DNA Damage Responses in the Tumor Microenvironment that Contribute to Cancer Therapy Resistance. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada601305.

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3

Mastro, Andrea M. Altering the Microenvironment to Promote Dormancy of Metastatic Breast Cancer Cell in a 3D Bone Culture System. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada604844.

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Mastro, Andrea M., and Erwin Vogler. Altering the Microenvironment to Promote Dormancy of Metastatic Breast Cancer Cell in a 3D Bone Culture System. Defense Technical Information Center, 2015. http://dx.doi.org/10.21236/ada621382.

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5

Ouyang, Zhiqiang, Qian Li, Guangrong Zheng, Tengfei Ke, Jun Yang, and Chengde Liao. Radiomics for predicting tumor microenvironment phenotypes in non-small cell lung cance: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.9.0060.

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Abstract:
Review question / Objective: Tumor microenvironment (TIME) phenotype is an important factor to affect the response and prognosis of immunotherapy in non-small cell lung cancer (NSCLC). Recently, accumulating studies have noninvasivly perdited the TIME phenotypes of NSCLC by using CT or PET/CT based radiomics. We will conduct this study by means of meta-analysis to eveluate the power and value of CT or PET/CT based radiomics for predicting TIME phenotypes in NSCLC patients. Condition being studied: At present, several recent prospective or retrospective cohort studies and randomized controlled
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6

She, Jingyao, Yue Chen, Chunyun Liang, Tong Chu, Jing Yu, and Peijuan Wang. Evaluating the Synergistic Impact of PD-1/PD-L1 Blockade and Platinum-Based Chemotherapy in Modulating the Tumor Microenvironment for Enhanced T Cell-Mediated Immune Responses in Advanced Endometrial Cancer: A Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2024. http://dx.doi.org/10.37766/inplasy2024.9.0121.

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7

Tang, Dean G. Microenvironment-Programmed Metastatic Prostate Cancer Stem Cells (mPCSCs). Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada613324.

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8

Luo, Yunping, and Ralph A. Reisfeld. Priming the Tumor Immune Microenvironment Improves Immune Surveillance of Cancer Stem Cells and Prevents Cancer Recurrence. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada574527.

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Reisfeld, Ralph R., Debbie Liao, and Yunping Luo. Priming the Tumor Immune Microenvironment Improves Immune Surveillance of Cancer Stem Cells and Prevents Cancer Recurrence. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada553886.

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10

Lee Sohn, Lydia. Using 3D Super-Resolution Microscopy to Probe Breast Cancer Stem Cells and Their Microenvironment. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada609488.

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