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Dissertations / Theses on the topic 'Cancer cells Breast Genes'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Wright, Paul Kingsley. "Identification of oestrogen-regulated genes in breast cancer cells." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493073.

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Oestrogens are critical agents in the aetiopathogenesis of breast cancer. Oestradiol (E2) acts via the oestrogen receptor (ER) to control the expression of specific genes, the full repertoire of which has not been established.

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2

Kao, Ruey-Ho. "Application of differential display technique to breast cancer tissue." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342256.

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3

Melkoumian, Zaroui K. "Pharmacological regulation of c-myc gene expression in human breast cancer cells." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2218.

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Thesis (Ph. D.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains x, 152 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 119-149).

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4

Chen, Chien-Cheng. "Mechanisms of transcriptional activation of estrogen responsive genes in breast cancer cells." Thesis, [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1869.

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5

Lafta, Inam Jasim. "STAG3 gene expression in breast cancer cells." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/12329/.

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The expression of cohesin genes has been found to be disregulated in a number of cancers including prostate, breast and squamous cell carcinoma; and mutations in genes that encode cohesin components have been noticed in colorectal cancer and myeloid malignancies (reviewed by Rhodes et al., 2011). It has been suggested that members of the cohesin complex might be considered as a subgroup of cancer biomarkers (Xu et al., 2011a). Therefore, this study focused on studying the expression of STAG genes in breast cancer cell lines and primary breast tumours. More attention was paid for STAG3, because

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6

Eyre, Rachel. "Determining the genes responsible for drug resistance in ovarian and breast cancer stem cells." Thesis, University of Newcastle Upon Tyne, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.576535.

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The majority of deaths in ovarian and breast cancer are caused by recurrent metastatic disease which is usually multidrug resistant. This progression has been hypothesised to be due in part to the presence of cancer stem cells, a subset of cells which are capable of self renewal and are able to survive chemotherapy and migrate to distant sites. Side population (SP) cells, identified by the efflux of the DNA binding dye Hoechst 33342 through ABC transporters, are a known adult stem cell group and have been suggested as a cancer stem cell in various cancers. The aims of this study were (i) to de

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7

Crook, Simon. "Identification and verification of genes regulated in breast cancer cells by the antiprogestin, Onapristone." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250455.

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8

Akhavantabasi, Shiva. "Functional Characterization Of Two Potential Breast Cancer Related Genes." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614275/index.pdf.

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Cancer may arise as a result of deregulation of oncogenes and/or tumor suppressors. Although much progress has been made for the identification of such cancer related genes, our understanding of the complex tumorigenesis pathways is still not complete. Therefore, to improve our understanding of how certain basic mechanisms work in normal and in cancer cells, we aimed to characterize two different breast cancer related genes. First part of the study focused on subcellular localization USP32 (Ubiquitin Specific Protease 32) to help understand the function of this uncharacterized gene. USP32 is a

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9

Davis, Jessica. "Identification of novel anti-hormone-induced pro-survival genes in oestrogen receptor-positive breast cancer cells." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/98607/.

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The growth inhibitory actions of antihormones in the treatment of oestrogen receptor-positive (ER+) breast cancer are compromised by the development of resistance. There is emerging evidence that antihormones can rapidly induce expression of genes that enable cells to survive the initial impact of these agents and ultimately aid the acquisition of resistance. The aims of this thesis were to identify novel antihormone-induced pro-survival genes in a panel of ER+ breast cancer cell lines and to determine whether such genes contribute to the limited efficacy of antihormones during response and su

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10

Wiese, Meike. "Characterisation of HP1γ in mammalian cells". Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273362.

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The degree of chromatin compaction plays a fundamental role in controlling the accessibility of DNA to the transcription machinery as well as other DNA-dependent biological pathways. The mammalian HP1 (Heterochromatin protein 1) protein family consists of three members: HP1α, β and γ. Each paralogue regulates formation and maintenance of heterochromatin by binding to the repressive chromatin marks H3K9me2/3 with their chromodomains (CDs). Despite high sequence conservation, each HP1 paralogue possesses specific functions, which are likely to be cell type specific. The aim of my thesis was to f

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11

Uppalapati, Lakshmi Deepthi. "Identification and characterization of unique tumoricidal genes in rat umbilical cord matrix stem cells." Thesis, Kansas State University, 2010. http://hdl.handle.net/2097/16797.

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Master of Science<br>Department of Anatomy & Physiology<br>Masaaki Tamura<br>Rat umbilical cord matrix stem cells (UCMSC) have been shown to exhibit a remarkable ability to control rat mammary adenocarcinoma (Mat B III) cell proliferation both in vivo and in vitro. To study the underlying mechanisms and genes involved in Mat B III growth attenuation, total RNA was extracted from the naïve rat UCMSC alone and those co-cultured with Mat B III in Transwell culture dishes. Gene expression profiles of naive rat UCMSC alone and those cocultured with Mat B III cells were investigated by microarray a

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12

Ngwenya, Sharon Khethiwe. "Regulation of E2F-1 gene expression in human breast cancer cells." Texas A&M University, 2003. http://hdl.handle.net/1969.1/2302.

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17β-Estradiol induces E2F-1 gene expression in ZR-75 and MCF-7 human breast cancer cells. Analysis of the E2F-1 gene promoter in MCF-7 cells previously showed that hormone-induced transactivation required interactions between estrogen receptor α (ERα)/Sp1 bound to upstream GC-rich sites and NFYA bound to downstream CCAAT sites within the -169 to -54 promoter region. This promoter region was also E2-responsive in ERα-positive ZR-75 cells; however, further analysis of the promoter showed that cooperative ERα/Sp1/NFY interactions were not necessary for hormone-induced transactivation in ZR-75 cel

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13

Bankole, Habeeb Adebodun. "In silico and molecular validation of identified putative genes and functional analysis of a N K G2D ligand as a breast cancer biomarkers." University of the Western Cape, 2015. http://hdl.handle.net/11394/4864.

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Philosophiae Doctor - PhD<br>The current diagnostic, prognostic, predictive and therapeutic monitoring methods used for breast cancer are limited. Thus, research into more specific, sensitive and effective strategies is required. Breast cancer is the most prevalent form of cancer in women worldwide and accounts for the most common cause of death in women every year. Cancer development is characterized by a wide spread of genetic abnormalities of gene sequences that can be used in detecting and monitoring treatment of the disease as a result of altered gene expression patterns which leave a t

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14

Lu, Shan. "Characterization, Epigenetic Drug Effect, and Gene Delivery to Breast Cancer Cells." University of Akron / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=akron1447718189.

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15

Motevalli, Azadeh. "Expression of shelterin and shelterin-associated genes in breast cancer cell lines." Thesis, Brunel University, 2014. http://bura.brunel.ac.uk/handle/2438/8492.

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Mammalian telomeric DNA consists of tandem repeats of the sequence TTAGGG associated with a specialized set of proteins, known collectively as Shelterin. These telosomal proteins protect the ends of chromosomes against end-to-end fusion and degradation. The objective of this project was to investigate whether expression of Shelterin and Shelterin-associated proteins are altered, and influence the protection and maintenance of telomeres, in breast cancer cells. Initial findings showed that most of the Shelterin and Shelterin-associated genes were significantly down-regulated (at the mRNA expres

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16

Calvo, Vidal Verónica Alejandra. "Searching for a functional relationship between the breast cancer susceptibility gene BRCA1 and the progesterone receptor in breast cancer cells." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7239.

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Germ-line mutations in the breast cancer susceptibility gene BRCA1 strongly increase the risk of developing breast and ovarian cancer in women. Different hypothesis have been proposed to explain this tissue specificity. One of the most argued hypothesis is the one that proposes a link between BRCA1 and ovarian hormones' action. Much data have been published in the last years pointing to an important role of progesterone receptor (PR) in inducing normal mammary development and also breast cancer formation. This study aimed to search for a functional relationship between BRCA1 and PR in breast c

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17

Egwuekwe, Ejike Roland. "Vitamin D Receptor Gene Polymorphisms Knowledge And Breast Cancer In Texas." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/6199.

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Breast cancer is a world health problem and is a leading cause of cancer-related death among women in the United States. However, breast cancer risks were reported to be reduced through exposure to Vitamin D through its Receptors identified as the p53 target gene. The purpose of this study was to assess the associations between VDR gene polymorphisms knowledge/awareness and decisions to reduce breast cancer risks and likelihood of mammogram screening among women in Texas. Data from survey were used. Roy adaptation model was the theoretical framework that guided this quasi- experimental, quanti

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18

Smith, David John. "Transcriptional regulation of the human cathepsin D gene in breast cancer cells." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320396.

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19

Slahudeen, Sameera. "Red palm oil as a therapeutic agent in triple-negative breast cancer patients." University of the Western Cape, 2020. http://hdl.handle.net/11394/8094.

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Magister Scientiae (Medical Bioscience) - MSc(MBS)<br>Purpose: Breast cancer is one of the most frequent and fatal diseases women all around the globe are challenged with today. In women, breast cancer has the highest mortality rate of all cancers and the incidence rate is on the increase. It is estimated that by the year 2025, 19.3 million women will become a victim of this grave health problem. This disease is a result of the formation of malignant tumours caused by genetic alterations that are involved in the proliferation of cells, cellular differentiation and the disturbance in homeostasi

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20

Wierer, Michael 1982. "Role of PLK1 in steroid hormone signaling in breast cancer cells." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/283474.

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Steroid receptors (SRs) are hormone-induced transcription factors that regulate gene expression by their concerted actions with coregulatory proteins. Performing a quantitative mass spectrometry-based interaction screen in breast cancer cells, we identified Polo-like kinase 1 to interact with progesterone receptor (PR) and estrogen receptor (ER) in presence of their respective hormone stimuli. PLK1 is recruited to chromatin and regulates SR-dependent and –independent gene transcription. Global gene expression analysis let us observe that PLK1-coactivated genes are enriched in developmental fun

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21

Clayton, Simon James. "Regulation of oestrogen receptor and oestrogen responsive genes by insulin, IGF-I, oestrogen and antioestrogens in breast cancer cells." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283743.

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22

Ohta, Naomi. "Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes." Thesis, Kansas State University, 2013. http://hdl.handle.net/2097/16730.

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Master of Science<br>Department of Anatomy and Physiology<br>Masaaki Tamura<br>Previous studies have shown that both human and rat umbilical cord matrix mesenchymal stem cells (UCMSC) possess the ability to control the growth of breast carcinoma cells. Comparative analysis of two types of UCMSC suggest that rat UCMSC-dependent growth regulation is significantly stronger than that of human UCMSC. Accordingly, the present study was designed to clarify their different tumoricidal abilities by analyzing gene expression profiles in two types of UCMSC. Gene expression profiles were studied by microa

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23

Khan, Shaheen Munawar Ali. "Mechanisms of hormonal regulation of CAD gene expression and inhibition by Aryl hydrocarbon receptor agonist in human breast cancer cells." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4935.

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The CAD gene is trifunctional and expresses carbamoylphosphate synthetase/aspartate carbamyltransferase/dihydroorotase, which are required for pyrimidine biosynthesis. CAD gene activities are induced in MCF-7 human breast cancer cells, and treatment of MCF-7 or ZR-75 cells with 17b-estradiol (E2) resulted in a 3-5 fold increase in CAD mRNA levels in both cell lines. E2 induced reporter gene activity in MCF-7 and ZR-75 cells transfected with a construct containing the growth-responsive -90/+115 (pCAD1) region of the CAD gene promoter, which contains three upstream GC-rich and two downstream E-b

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24

Christensen, Kimberly Laura. "The developmental regulator SIX1 plays multiple roles in breast cancer initiation and progression /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Biophysics & Genetics, Program in Molecular Biology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 115-132). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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25

Park, Jung. "The transcription factor activator protein family of genes in mammary gland development and breast cancer progression." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/5596.

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Breast cancer is currently the second most common form of cancer and the second leading cause of death due to cancer in the United States. Breast cancer itself is subdivided into at least four subtypes, luminal A, luminal B, HER2-enriched, and basal-like, based on genomewide molecular expression patterns. Luminal A is the most common form and typically characterized by high levels of estrogen receptor (ER). HER2-enriched cancers usually, but not always, harbor amplified copies of the HER2 oncogene. Luminal B cancers share characteristics with the luminal A and HER2-enriched subtypes. Finally,

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26

Abdel, Rahim Ma'en Ahmad. "Gene silencing in cancer cells using siRNA : genetic and functional studies." Diss., Texas A&M University, 2004. http://hdl.handle.net/1969.1/218.

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Sequence-specific small interfering RNA (siRNA) duplexes can be used for gene silencing in mammalian cells and as mechanistic probes for determining gene function. Transfection of siRNA for specificity protein 1 (Sp1) in MCF-7 or ZR-75 cells decreased Sp1 protein in nuclear extracts, and immunohistochemical analysis showed that Sp1 protein in transfected MCF-7 cells was barely detectable. Decreased Sp1 protein in MCF-7 was accompanied by a decrease in basal and estrogen-induced transactivation and cell cycle progression. These results clearly demonstrate the key role of Sp1 protein in regulati

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27

Tezcan, Okan. "Metastatic Behaviour Of Doxorubicin Resistant Mcf-7 Breast Cancer Cells After Vimentin Silencing." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615553/index.pdf.

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Chemotherapy is one of the common treatments in cancer therapy. The effectiveness of chemotherapy is limited by several factors one of which is the emergence of multidrug resistance (MDR). MDR is caused by the activity of diverse ATP binding cassette (ABC) transporters that pump drugs out of the cells. There are several drugs which have been used in treatment of cancer. One of them is doxorubicin that intercalates and inhibits DNA replication. However, doxorubicin has been found to cause development of MDR in tumors. It has been reported that there is a correlation between multidrug resistance

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28

Labrèche, Cédrik. "The Role of Periostin in ErbB2-Driven Mammary Tumorigenesis and its Gene Regulation in ErbB2+ Cancer Cells." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/42753.

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Breast cancer is a highly heterogeneous disease with multiple drivers and a complex regulatory network. Periostin (Postn) is a matricellular protein involved in a plethora of cancer types and other diseases. More specifically, Postn has been shown to be involved in various processes of tumor progression such as angiogenesis, cell survival, invasion, and metastasis. A high Postn level in breast cancer has been corelated with a more aggressive phenotype. Despite extensive research, it remains unclear what Postn is doing to the cancer environment and how cancer cells regulate Postn. Here, we asse

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29

Wood, Timothy Paul. "Identification of key mechanism in the cytotoxic effect of two novel anti-cancer compounds on breast cancer cells." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/24532.

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Organometallic chemotherapeutic agents, many of which target DNA, have been shown to be effective in the treatment of cancer. With that said though, these compounds have a number of side affects such as nephrotoxicity. Two novel compounds, Ferrocene [ferrocenoyltrichloroacetone] and Rhodium-ferrocene [(1.5 cyclooctadiene)(1-ferrocenyl- 4,4,4-trichloro-1,3-butanedionate], synthesised by the research group of J Swarts (University of the Free State) were evaluated to determine their mechanism of action and their potential use as novel therapeutic agents. It is hypothesized, by merit of their chem

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30

Sancho, Medina Mònica. "Role of linker Histone H1 variants in cell proliferation, Chromatin Structure and Gene expression in breast cancer cells." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7118.

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At least eleven histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition of playing a structural role, H1 seems to be involved in the activation and repression of gene expression. It is not well known whether the different variants have specific roles or regulate specific promoters. We have explored this by inducible shRNA-mediated knock-down of each of the H1 variants in a human breast cancer cell line. Rapid inhibition of each H1 variant was not compensated by changes

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31

Kim, Ju Young. "Transcriptional regulation of glycosyltransferase genes in MCF-7 human breast cancer cell line following drug treatment." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29866.

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Bioinformatics is a subfield in computational science that is principally focused on developing methods and performing data analytics in the areas of proteomics and genomics. In this thesis I draw a link between proteomics and genomics by focusing on the regulation patterns of glycosyltransferase (GT) genes in breast cancer cell line following the treatment with a large set of Food and Drug Administration (FDA) approved drugs. This is based on the understanding that aberrant glycosylation in breast cancer tumours stem from altered GT gene expression. A major goal of genomic research is the ide

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32

Husbeck, Bryan. "Changes in gene expression induced by thioredoxin-1 in MCF-7 human breast cancer cells." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/280113.

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Thioredoxin-1 (Trx-1) is a small redox protein that is overexpressed in a number of human cancers. Elevated levels of Trx-1 in tumors is associated with increased cell proliferation, decreased apoptosis, and decreased patient survival. However, the mechanism(s) for the growth stimulating and anti-apoptosis effects of Trx-1 are unknown. We used DNA microarray technology to identify genes whose expression was altered in MCF-7 breast cancer cells stably transfected with wild-type Trx-1 (MCF-7/Trx 9) or a redox inactive mutant Trx-1 (MCF-7/SerB 4) compared to empty-vector transfected cells (MCF-7/

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33

Bellucci, Luca. "The role of histone variant H2A. Z in the regulation of gene expression in breast cancer cells." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/1939/.

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Pendant mes trois ans de thèse, j'ai étudié les mécanismes de régulation génique impliqués dans le cancer du sein. Je me suis intéressé en particulier à la régulation épigénétique du gène p21 dans les cellules cancéreuses mammaires hormono-indépendantes, ERa-négatives (MDA-MB231). Nous avons démontré que l'activation du gène p21 dans ces cellules était p53 indépendante, stimulée en utilisant des inhibiteurs des histones deacétylases et contrôlée par l'acétylation du variant d'histone H2A. Z. Mes études ont permis la rédaction et publication d'un article (Bellucci et al. , 2013 [1]). Selon les

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34

Hunter, Rebecca Stephanie. "Inhibition of ErbB2 and Thymidylate Synthase by a Multi-Targeted Small-Interfering RNA in Human Breast Cancer Cell Lines." Yale University, 2008. http://ymtdl.med.yale.edu/theses/available/etd-08092007-140112/.

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The therapeutic potential of a novel multi-targeted small-interfering RNA (siRNA) was investigated in human breast cancer cells. Previous studies had identified an siRNA that specifically and potently inhibited expression of thymidylate synthase (TS) by directly targeting human TS mRNA. TS is a folate-dependent enzyme that catalyzes the key reaction involved in synthesizing nucleotide precursors for DNA biosynthesis, and as such, it plays a critical role in maintaining cell growth. The goal of this thesis was to design and develop a novel siRNA molecule that targeted TS mRNA as well as a cellu

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35

Higgins, Kelly Jean. "Regulation of vascular endothelial growth factor receptor-2 in pancreatic and breast cancer cells by Sp proteins." Texas A&M University, 2003. http://hdl.handle.net/1969.1/6010.

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Vascular endothelial growth factor receptor-2 (VEGFR2) is a key angiogenic factor, and angiogenesis is an important physiological process associated with neovascularization, growth, and metastasis of many different tumors. The mechanism of VEGFR2 gene expression was investigated in MiaPaCa-2, Panc-1, and AsPC-1 pancreatic cancer cells transfected with a series of VEGFR2 promoter deletion/mutated constructs, and the results indicated that the GC-rich Ã¢ÂÂ60 to Ã¢ÂÂ37 region of the promoter was essential for VEGFR2 expression in these cell lines. EMSA and ChIP assays showed that Sp proteins

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36

D’Anello, Laura <1980&gt. "Epigenetic control of the basal-like gene expression profile via Interleukin-6 in breast cancer cells." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3368/.

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37

Gu-Trantien, Chunyan. "Gene expression profiling of CD4+ T cells infiltrating human breast carcinomas identified CXCL13-producing T follicular helper cells associated with tertiary lymphoid structures and better patient outcome." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209474.

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<p>Over the past decade, studies using murine models have led to the demonstration that CD4+ T helper (Th) cells play a critical role in the control of cancer progression. Additional support for their importance comes from the growing body of recent clinical/translational research data demonstrating the importance of tumor-infiltrating T and B lymphocytes in long-term patient survival for various types of cancer, including breast cancer (BC). As the key population coordinating adaptive immune responses, the role(s) played by individual Th subsets in cancer immunity remains largely controversia

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38

Stone, Andrew. "Identification of genes associated with the maintenance of the tamoxifen resistant breast cancer cell phenotype following tamoxifen withdrawal." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/55814/.

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Despite the benefit tamoxifen has provided for millions of breast cancer patients worldwide, almost all patients with metastatic disease and as many as 40 of patients receiving adjuvant tamoxifen treatment will acquire resistance to the drugs inhibitory effect on breast cancer cell growth. Previous studies in the Tenovus Centre have demonstrated that the development of anti-oestrogen resistance in vitro is associated with aberrant growth factor signaling which facilitates a more aggressive cell phenotype. The aim of the present study was to determine whether the undesirable characteristics of

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39

Singh, Anjana. "Development of a reporter gene assay to determine estrogen receptor activity in purified primary breast cancer cells." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418052.

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40

Man, Yicun [Verfasser]. "On the functional relevance of the gene DEP domain containing 1 in breast cancer cells / Yicun Man." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1035405989/34.

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41

Montanez-Wiscovich, Marjorie E. "Discerning the Role of LMO4 as a Global Modulator of G2/M Cell Cycle Progression and Centrosome Cycle in Breast Cancer Cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1259899890.

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42

Jeffy, Brandon David. "Molecular interactions between endogenous and exogenous factors: Regulation of BRCA-1 tumor suppressor gene expression in breast cancer cells." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/280421.

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This dissertation focuses on the central hypothesis that in breast cancer cells containing the estrogen receptor-α (ER-α+) and wild-type p53, the BRCA-1 tumor suppressor gene is positively regulated by the steroid hormone estrogen and negatively regulated by Aromatic Hydrocarbon Receptor (AhR) ligands which damage DNA. In this dissertation, we demonstrate that BRCA-1 promoter activity is reduced by the DNA damaging agent Benzo[a]pyrene in breast cancer cells containing both a functional estrogen receptor and p53 pathway. In addition, our data suggests that exposure of MCF-7 breast cancer cells

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43

Ghatge, Radhika P. "Medroxyprogesterone acetate : a dual function hormone that is both a progestin and an androgen in human breast cancer cells /." Connect to full text via ProQuest. IP filtered, 2005.

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44

Mardilovich, Katerina. "Insulin Receptor Substrate-2 (IRS-2): A Novel Hypoxia-Responsive Gene in Breast Cancer: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/533.

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Breast cancer is the most common malignancy among women in the U.S. While many successful treatments exist for primary breast cancer, very few are available for patients with metastatic disease. The purpose of this study was to understand the role of Insulin Receptor Subtrate-2 (IRS-2) in breast cancer metastasis. IRS-2 belongs to the IRS family of cytoplasmic adaptor proteins that mediate signaling from cell surface receptors, many of which have been implicated in cancer. Although the IRS proteins are highly homologous in structure and have some complementary functions, growing evidence suppo

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45

Richter, Suzanne C. "New approaches to molecular diagnostics, identification of differentially expressed genes in breast cancer cell lines using cDNA aray hybridization and sequence analysis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0009/MQ40773.pdf.

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46

Yilmaz, Selis. "Antioxidant And Cytotoxic Properties Of Salvia Absconditiflora And Effects On Cyp1a1, Cyp1b1 Gene Expressions In Breast Cancer Cell Lines." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615663/index.pdf.

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Salvia genus is a widely cultivated genus and used in medicine for various purposes as having antimicrobial, antioxidant, anticarcinogen and anti-inflammatory features. In this study the aim was to investigate phenolic composition of Salvia absconditiflora and understand the possible effects of those constituents in cancer related drug metabolizing enzymes. Salvia absconditiflora showed 80,43 % Radical Scavenging Activity against DPPH radical. Total flavonoid content was found as one third of total phenolic content. Presence of important phenolic acids and flavonoids such as caffeic acid, lute

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Albuquerque, Andreia de, Sepp Kaul, Georg Breier, Petra Krabisch, and Nikos Fersis. "Multimarker Analysis of Circulating Tumor Cells in Peripheral Blood of Metastatic Breast Cancer Patients: A Step Forward in Personalized Medicine." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136627.

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Aim: To develop an immunomagnetic assay for the isolation of circulating tumor cells (CTCs) followed by the analysis of a multimarker panel, which will enable the characterization of these malignant cells with high accuracy. Patients and Methods: Peripheral blood (PB) was collected from 32 metastatic breast cancer patients and 42 negative controls. The antibodies BM7 and VU1D9 were used for immunomagnetic tumor cell enrichment. A real-time reverse transcription-polymerase chain reaction (RT-PCR) approach for the markers KRT19, SCGB2A2, MUC1, EPCAM, BIRC5 and ERBB2 was used for CTC detection an

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Albuquerque, Andreia de, Sepp Kaul, Georg Breier, Petra Krabisch, and Nikos Fersis. "Multimarker Analysis of Circulating Tumor Cells in Peripheral Blood of Metastatic Breast Cancer Patients: A Step Forward in Personalized Medicine." Karger, 2012. https://tud.qucosa.de/id/qucosa%3A27718.

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Aim: To develop an immunomagnetic assay for the isolation of circulating tumor cells (CTCs) followed by the analysis of a multimarker panel, which will enable the characterization of these malignant cells with high accuracy. Patients and Methods: Peripheral blood (PB) was collected from 32 metastatic breast cancer patients and 42 negative controls. The antibodies BM7 and VU1D9 were used for immunomagnetic tumor cell enrichment. A real-time reverse transcription-polymerase chain reaction (RT-PCR) approach for the markers KRT19, SCGB2A2, MUC1, EPCAM, BIRC5 and ERBB2 was used for CTC detection an

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Silveira, Giórgia Gobbi da. "Relação entre o gene B-Cell-Specific Moloney Murine Leukemia Virus Integration Site 1 (BMI-1) e genes reguladores da recombinação homóloga em carcinomas ductais invasores da mama." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/17/17143/tde-08082014-112232/.

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Bmi-1 é uma proteína do grupo Polycomb capaz de induzir atividade de telomerase, levando à imortalização de células epiteliais. As células, quando imortalizadas, se tronam mais susceptíveis a danos em dupla fita (double-strand breaks (DSB))e a recombinação homóloga é uma das duas vias de reparo dos DSBs. Dentre os genes reguladores da recombinação homóloga temos o BRCA-1, que está envolvido na resposta ao dano associado à proteína RAD51, que por sua vez se acumula rapidamente nos focos de dano ao DNA após a sinalização do H2AX, que têm se mostrado um excelente marcador de dano celular por se a

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Neil, Jason Robert. "TGF-ß promotes cancer progression through the xIAP:TAB₁:TAK₁:IKK axis in mammary epithelial cells /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Pharmacology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 117-147). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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