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Dissertations / Theses on the topic 'Cancer cells metabolism'

Author: Grafiati

Published: 14 March 2023

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1

Simon, Molas Helga. "Exploring the regulation and function of TIGAR in cancer cells." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667414.

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The TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) gene was described in 2006 by Dr. Karen Vousden's group in response to the induction of the tumour suppressor gene p53. Since then, numerous studies have focused on clarifying the role of this gene in the metabolism of tumour cells. TIGAR was initially described as an enzyme with bisphosphatase activity on fructose-2,6-bisphosphate, a key metabolite in the positive allosteric regulation of phosphofructokinase-1, which catalyses a key reaction in glycolysis. Through this bisphosphatase activity, TIGAR reduces the levels of fructose-2,

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2

Board, Mary. "A study of energy metabolism in neoplastic cells." Thesis, University of Oxford, 1990. http://ora.ox.ac.uk/objects/uuid:d3e13e31-3fe8-4cd8-ad71-50d4e7df4d27.

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3

Vermeersch, Kathleen A. "Systems-level characterization of ovarian cancer metabolism." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54258.

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The purpose of this thesis was to characterize cancer metabolism in vitro using epithelial ovarian cancer as a model on an untargeted, systems-level, basis with particular attention paid to the difference between cancer stem cell metabolism and cancer cell metabolism. Two-dimensional gas chromatography coupled to mass spectrometry was used to measure the metabolite profiles of the ovarian cancer and cancer stem cell lines under normal baseline conditions and also under chemotherapeutic and environmental perturbations. These two cell lines exhibited significant metabolic differences under norma

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4

Hjertman, Magnus. "Protein modification with hydrophobic prenyl groups in malignant cells /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-7349-063-6/.

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5

Ross, Helen L. "The metabolism of benzo(a)pyrene in human cells." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253019.

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6

Pyne, Emily Seton. "The Impact of Stromal Cells on the Metabolism of Ovarian Cancer Cells in 3D Culture." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/74931.

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Academic: Ovarian cancer is the leading cause of death among female gynecologic cancers. Current treatments include surgical debulking, and chemotherapy. However, better interventions are needed to reduce the mortality rate of metastatic disease. Ovarian cancer cells have displayed the ability to aggregate and form 3D homogeneous and heterogeneous spheroids, which can function as micrometastases. Ovarian cancer spheroids survive independently prior to adhering to an endothelial tissue. Since aggregation has been shown to provide a survival advantage to the spheroids and increased their aggres

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7

Wang, Feng. "Interaction between pancreatic cancer and beta cells : intraislet significance of islet amyloid polypeptide /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3300-6/.

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8

Maddula, Sasidhar [Verfasser]. "Cell cycle phase specific metabolism of colon cancer cells: a metabolome study / Sasidhar Maddula." München : Verlag Dr. Hut, 2011. http://d-nb.info/1018980911/34.

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9

E, Pranzini. "Metabolic reprogramming of colorectal cancer cells resistant to 5-FU." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1095546.

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Metabolic rearrangements are essential to satisfy the different needs of cancer cells during tumorigenesis. Recent studies highlighted a role for such metabolic reprogramming in adaptation to therapies and chemo-resistance development. 5-fluorouracil (5-FU) is an antimetabolite drug widely used as a first-line treatment for colorectal cancer. Despite several advantages of 5-FU, its clinical application is still greatly limited, due to the acquisition of drug resistance. In the first part of this thesis, we illustrate the role of micro RNAs (miRNAs) in reprogramming colon cancer cells toward

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10

Bellio, Chiara. "Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424111.

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Ovarian cancer is the fourth leading cause of cancer-related death in women and the leading cause of gynecologic cancer death. Moreover, it is regarded as a therapy resistant tumor, because it shows the formation of more aggressive recurrence of the primary tumor as a result of chemotherapy. This chemo-resistance is thought to be related to the presence of the Cancer Stem Cells (CSC). Tumor cells are characterized by a high glycolytic metabolism even in the presence of oxygen, the so-called Warburg effect; however, it is unclear whether this condition is also shared by CSC. We identified ov

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11

Charalambous, Michalis. "Investigating the metabolism of breast cancer cells using 1H-NMR based metabonomics." Thesis, University of Leeds, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.659185.

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Background There are complex metabolic processes occurring in normal, benign and malignant breast cells. To date, there have been relatively few NMR and metabonomic studies investigating these processes in either cultured breast cells or in human biofluids. Aims To develop a combination method of harvesting and lysing cultured breast cells without using any chemicals, which may affect their metabolism, and to determine and compare the metabolic profile of MCF-7 and MCF_7MMU-2 human breast cancer cells by 1 H-NMR spectroscopy and metabonomics. A second aim was to collect and compare by 1 H-NMR-

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12

Cufí, González Sílvia. "Bioenergetics mechanism and autophagy in breast cancer stem cells." Doctoral thesis, Universitat de Girona, 2015. http://hdl.handle.net/10803/295461.

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Aquest és el primer informe que demostra que l'autofàgia està mecànicament vinculat al manteniment de les cèl•lules tumorals que expressen alts nivells de CD44 i baixos nivells de CD24, que són típics de les cèl•lules mare del càncer de mama. Els nostres resultats actuals proporcionen una nova visió de com la divisió mitocondrial s'integra a la xarxa de la transcripció impulsada per factors de reprogramació, especifica de la pluripotència única de les cèl•lules mare. L'autofàgia pot controlar la refractarietat de novo de carcinomes de mama amb el gen HER2 amplificat per l'anticòs monoclonal

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13

MUGNAIONI, CAMILLA. "Bisphosphoglyceratemutase (BPGM): a central role in metabolism of proliferating cells." Doctoral thesis, Università di Siena, 2016. http://hdl.handle.net/11365/1008257.

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Many kind of cancer cells exploit glycolysis rather than oxidative phosphorylation for energy production even in the presence of oxygen. This kind of metabolism, although less efficient in terms of ATP production, generates high levels of glycolytic intermediates necessary to support the high biosynthetic flux of rapidly proliferating cells. . This mechanism is further enhanced in cancer cells by the expression of a particular form of pyruvate kinase -M2 (PKM2) which promote a low efficiency glycolysis (in terms or ATP production) and consequently an increase in the formation of biosynthetic m

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14

Xu, Xiangcong. "THE MOLECULAR MECHANISMS OF IRON AND FERRITIN METABOLISM IN." University of Sydney, 2008. http://hdl.handle.net/2123/3535.

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Doctor of Philosophy(PhD)<br>Iron (Fe) is essential for cell growth and replication as many Fe-containing proteins catalyse key reactions involved in energy metabolism (cytochromes, mitochondrial aconitase and Fe-S proteins of the electron transport chain), respiration (hemoglobin and myoglobin) and DNA synthesis (ribonucleotide reductase). If not appropriately shielded, Fe could participate in one-electron transfer reactions that lead to the production of extremely toxic free radicals. The Fe storage protein, ferritin, is essential to protect cells against Fe-mediated oxidative stress by acco

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Asiri, Sumayyah. "Role of Cu metabolism in the cisplatin-sensitive and resistant ovarian cancer cells." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29652.

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Ovarian cancer is the fourth most common cancer among women worldwide, leading to high mortality rates. Platinum anti-cancer drugs have been widely used in the treatment of ovarian cancers, but the development of resistance to these drugs is a rapidly growing impediment for their clinical use. Studies of the cell morphology using IncuCyte Zoom and HoloMonitor M4 have shown that A2780.CisR cells contained heterogeneous cell populations that partially underwent epithelial-to-mesenchymal transition (EMT). Mesenchymal A2780.CisR cells were likely to be more resistant to a cytotoxic natural killer

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Xu, Xiangcong. "THE MOLECULAR MECHANISMS OF IRON AND FERRITIN METABOLISM IN NORMAL AND NEOPLASTIC CELLS." Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3535.

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Iron (Fe) is essential for cell growth and replication as many Fe-containing proteins catalyse key reactions involved in energy metabolism (cytochromes, mitochondrial aconitase and Fe-S proteins of the electron transport chain), respiration (hemoglobin and myoglobin) and DNA synthesis (ribonucleotide reductase). If not appropriately shielded, Fe could participate in one-electron transfer reactions that lead to the production of extremely toxic free radicals. The Fe storage protein, ferritin, is essential to protect cells against Fe-mediated oxidative stress by accommodating excess Fe into its

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17

Pilotto, G. "Metabolic and molecular profiling of ovarian cancer stem cells and cancer non-stem counterpart." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425716.

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Epithelial Ovarian Cancer (EOC) is a very malignant neoplasm, accounting for 5% of cancer mortality in women. Although progress has been made in EOC treatments by improved debulking surgery and platinum-taxane regimens, the 5-year survival rate of advanced-stage EOC remains below 30%. This poor prognosis relies on the one hand on the late diagnosis and on the other on the chemo-resistance occurring after only a few months from the completion of treatment. The reasons for recurrence and cancer drug resistance remain uncertain. Recent evidence suggests that EOC, akin most tumors, contains a tin

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18

Hyroššová, Petra. "Not to be picky: PEPCK-M ensures metabolic flexibility in cancer cells and neuronal progenitors." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/672607.

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Phosphoenolpyruvate carboxykinase (PEPCK) is an enzyme that catalyses decarboxylation of oxaloacetate to phosphoenolpyruvate and it is part of gluconeogenic/glyceroneogenic pathway. There are two known isoforms of PEPCK, the mitochondrial and the cytosolic isozyme that are catalysing chemically identical reactions, but they differ in regulation and expression pattern. Selective presence of mitochondrial isoform of this enzyme (PEPCK-M, PCK2) in all types of cancer examined and in cycling neuroprogenitors, suggests a functional relationship with the metabolic adaptations of these cells. This th

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19

Macoritto, Michael. "Mechanisms of vitamin D receptor and retinoid X receptor mediated hormone resistance and cell differentiation in normal and cancer cells." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111887.

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Vitamin D is a precursor to a steroid hormone, 1,25 dihydroxyvitamin D (1,25(OH)2D). After its discovery and the characterization of its receptor, the vitamin D receptor (VDR), it was initially thought only to be involved in calcium homeostasis, but further research revealed an important role for vitamin D in the regulation of cell growth and differentiation of such cells as osteoblasts and bone marrow adipocytes. 1,25(OH)2D has also been shown to be a strong inhibitor and pro-differentiator of keratinocytes. The anti-proliferative and pro-differentiative properties of this hormone have led to

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Zasada, Christin. "Experimental and mathematical analysis of the central carbon metabolism in cancer and stem cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18309.

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Die Entstehung von Tumoren und damit einhergehenden Veränderungen wurden insbesondere im letzten Jahrzehnt kontrovers diskutiert. Bisher standen nur wenige Datensätze mit ausreichender Datendichte zur Verfügung um eine umfassende Untersuchung der Regulation des Stoffwechsels durchzuführen. Die in dieser Arbeit zusammengefassten Projekte adressieren verschiedene Aspekte der Stoffwechselregulation und beschreiben die Verknüpfung von Zellkulturexperimenten mit innovativen Hochdurchsatz-Technologien, komplexer Datenanalyse und Computer-basierter Modellierung zur Bestimmung der Stoffwechselflüsse i

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21

Ojo, Evelyn. "Approaches to Improve the Proliferation and Activity of Natural Killer Cells for Adoptive Cell Therapy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1536760957918928.

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22

Iwamoto, Masayoshi. "Regulation of 18F-FDG Accumulation in Colorectal Cancer Cells with Mutated KRAS." Kyoto University, 2015. http://hdl.handle.net/2433/199162.

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23

Anderson, Angela S. "Characterization of Metabolic Differences in Benign, Slow Developing and Tumor Initiating Ovarian Cancers." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/50812.

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Ovarian cancer is known as the "silent killer," due to its late diagnosis and frequent recurrence after initial treatment. Finding a new way to diagnose and treat ovarian cancer in conjunction with current therapies is paramount. By capitalizing on metabolic changes that occur during cancer progression, interventions can be developed. The Nobel laureate Otto Warburg is credited with discovering an altered metabolic state within cancer cells known as the Warburg effect. In the Warburg effect, cancer cells participate in an increased rate of aerobic glycolysis with an excess secretion of lac

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24

Polat, Ibrahim H. "Functional role of pentose phosphate pathway and glutamine in cancer cell metabolism." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/402580.

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In this thesis, tumor metabolic reprogramming has been exploited in order to propose new targets in cancer treatment. On one hand, we explored the pentose phosphate pathway (PPP) enzymes as putative therapeutic targets against breast and colon cancer. We observed that inhibition of ox-PPP enzymes G6PD in colon cancer cells and 6PGD in breast cancer cells halted cell prolifertion, resulted in cell cycle arrest and apoptosis. We also demosntrated that in colon cancer cells G6PD is strongly regulated by the glutamine availability mediated by NRF2 transcription factor. Moreover, 6PGD inhibition de

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Venturelli, Leonardo. "Glucose coated nanoparticles for mesenchymal cancer cells recognition." Doctoral thesis, Università degli studi di Trieste, 2015. http://hdl.handle.net/10077/10901.

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2013/2014<br>Lo scopo del presente progetto di Dottorato riguarda la possibilità di riconoscere ed identificare le cellule mesenchimali del cancro sfruttando il metabolismo iper-attivato, nonché de-regolato, delle stesse. Una delle differenze principali tra le cellule epiteliali e quelle mesenchimali, del cancro, è il metabolismo ed in particolare il così detto Effetto Warburg (da Otto Einrich Warburg il suo scopritore e sostenitore, nel 1926). Nello specifico, questo effetto riguarda la caratteristica delle cellule tumorali di preferire, come via metabolica, la glicolisi alla classica fosfori

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Aguilar, Fadó Esther. "Metabolic reprogramming and vulnerabilities of prostate cancer stem cells independent or epithelial-mesenchymal transition." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/291812.

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Metastasis represents the most life-threatening aspect of tumorigenesis and is the leading cause of death by cancer. Intensive research in this field has shed light on some of the molecular strategies employed by the heterogeneous cancer cell populations to leave the primary tumor, disseminate and grow new colonies in distant organs. In any given tumor, one important functional category of cancer cells is represented by cancer stem cells (CSCs), endowed with self-renewal and tumor-initiating potentials. Moreover, the epithelial-mesenchymal transition (EMT) program represents a process of fund

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Wilson, Miranda Sophie Claire. "The role of FOXO3a in the cellular stress response and metabolism of breast cancer cells." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/10131.

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The development of acquired resistance to chemotherapeutic drugs is often a limiting factor in the treatment of cancer. In this study, I investigated alterations in MAP kinase signalling and metabolism in a doxorubicin/epirubicin-resistant breast cancer cell line. Doxorubicin, also known as adriamycin, is one of the most important drugs in the treatment of breast cancer. The MAP kinases ERK, JNK, and p38 have all been linked to drug response and tumorigenesis, as well as apoptosis, in different cell types. I found that ERK activity was downregulated in the resistant cell line, while transcript

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Ramírez, Peinado Silvia. "Caracterización de la muerte celular inducida mediante la inhibición del metabolismo de la glucosa." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/107756.

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Las células tumorales presentan alteraciones metabólicas. Una de las diferencias con las células no transformadas es que los tumores usan más glucosa incluso en condiciones de normoxia, lo que se utiliza actualmente para visualizar tumores mediante la técnica de PET. Ultimamente se están desarrollando terapias basadas en estas particularidades metabólicas de las células tumorales, que las hacen más sensibles a inhibición del metabolismo glicolítico. Aquí estudiamos la muerte producida por la falta de glucosa en sarcomas y otros tipos tumorales. La privación de glucosa induce apoptosis o nec

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PALORINI, ROBERTA. "K-ras cancer cell fate under glucose deprivation is influenced by alteration of bioenergetic metabolism." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41975.

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Molte cellule tumorali, al fine di generare ATP e sostenere i processi anabolici, si servono principalmente della glicolisi piuttosto che della respirazione mitocondriale. Di conseguenza, il glucosio assume un ruolo critico per la sopravvivenza e la proliferazione delle cellule tumorali. Inoltre, attraverso la via dei pentosi fosfati, il glucosio porta alla formazione di NADPH, contribuendo al mantenimento nelle cellule dell’equilibrio ossidativo. Nondimeno, il glucosio può entrare anche nel pathway biosintetico delle esosammine (HBP), sostenendo la N- e O-glicosilazione di lipidi e proteine,

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Qian, Yanrong. "Internalization of Extracellular ATP in Cancer Cells and Development of New Generations of Anticancer Glucose Transport Inhibitors." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1416411921.

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31

Miettinen, M. (Minna). "17β-hydroxysteroid dehydrogenase types 1 and 2:expression and activities in various tissues and cell lines and effect of the type 1 enzyme on estrogen-dependent growth of breast cancer cells". Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514254163.

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Abstract 17β-Hydroxysteroid dehydrogenases (17HSDs) catalyze the reactions between 17-hydroxy and 17-keto steroids. In the present study, the enzyme activities and tissue distribution of 17HSD type 1, type 2 and type 4 were characterized. Furthermore, the role of 17HSD type 1 in estrogen-dependent growth was studied in MCF-7 breast cancer cells which were stably transfected with type 1 cDNA. Endogenous oxidative 17HSD activity found in COS-m6 monkey kidney cells was first compared with that of human placental 17HSD. Cultured COS-m6 cells exclusively possessed oxidative 17HSD activity, convert

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Ikeda, Atsushi. "Colorectal cancer-derived CAT1-positive extracellular vesicles alter nitric oxide metabolism in endothelial cells and promote angiogenesis." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265183.

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Kim, Jin Young Leo. "METABOLIC CONTROL OF THE EPIGENOME IN GLIOBLASTOMA STEM CELLS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case157616602610095.

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Jones, Travis Hamilton. "On the Interactions of Electromagnetic Fields with Human Cells." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1587493583447491.

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André, Fanny. "Influence du métabolisme mitochondrial dans la survie et la mort des cellules tumorales : intérêt du ciblage mitochondrial pour le traitement des cancers." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL2S001/document.

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La mitochondrie occupe un rôle essentiel au sein des cellules cancéreuses. Etant la source principale de synthèse d’ATP mais est également le lieu de réactions anaboliques et cataboliques, la mitochondrie supporte le développement tumoral. De plus, la mitochondrie est également impliquée dans la réponse aux stress cellulaire en régulant notamment l’autophagie ou la mort des cellules cancéreuses.Dans ce contexte, nous avons démontré que la fonction mitochondriale peut altérer la réponse au stress réticulaire permettant la survie des cellules tumorales. En effet, la surexpression de la protéine

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36

Liuzzi, Francesca <1992&gt. "Modulation of cancer energy metabolism: the role of the ATPase inhibitor factor 1 (IF1) in the bioenergetics of cancer cells experiencing oxygen deprivation." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amsdottorato.unibo.it/9515/1/PhD%20thesis_Francesca%20Liuzzi.pdf.

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IF1, the endogenous inhibitor protein of mitochondrial F1Fo-ATPase, has raised interest in cancer research due to its overexpression in solid tumours compared to normal tissues. Physiologically, IF1 protects cells from energy depletion by limiting the ATP hydrolytic activity of ATP synthase triggered by mitochondrial depolarization caused by oxygen deficiency as it occurs during ischemic episodes. Considering both the physiological function of IF1 and that cancer cells in solid tumour are frequently exposed to oxygen deprivation, we hypothesized that IF1 overexpression represents a strategy th

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Fuhr, Luise Anna. "The Circadian Clock Modulates Tumour Progression and Drug Response in Colorectal Cancer Cells through Metabolic Phenotype Rewiring." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/20850.

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Die zirkadiane Uhr ist ein endogenes Zeitmesssystem, das die Anpassung physiologischer Prozesse an die geophysikalische Zeit ermöglicht. Die zirkadiane Uhr besteht aus einem zentralen Schrittmacher und peripheren Uhren in jeder Zelle. Bei Säugern ist eine bestimmte Anzahl von Uhr-Genen in regulatorischen Schleifen miteinander verbunden, wodurch Oszillationen in der Expression der Uhr-Gene sowie in zahlreichen Zielgenen erzeugt werden. Zielgene der zirkadianen Uhr sind unter anderem an zellulären Prozessen beteiligt, die eine Rolle bei der Tumorentstehung und -progression spielen. Funktionsstör

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Tousignant, Kaylyn Davis. "Investigation of metabolic rewiring in prostate cancer cells during the adaptive response to androgen-targeted therapies." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/180822/1/Kaylyn_Tousignant_Thesis.pdf.

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The development of therapy resistance is a major obstacle in the successful treatment of advanced prostate cancer. This thesis investigated mechanisms that help drive therapy resistance and discovered that prostate cancer cells can utilise different metabolic pathways in order to become resistant to current therapies. This project also explores new therapeutic strategies to use in combination with current treatments to help fight disease progression and improve outcomes for men with prostate cancer.

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Du, Toit Therina. "An investigation into the influence of rooibos (Aspalathus linearis) on androgen metabolism in normal and prostate cancer cells." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96926.

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Thesis (MSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: In this study, the influence of rooibos on the catalytic activity of enzymes 17β -hydroxysteroid dehydrogenase type 3 (17βHSD3), 17β-hydroxysteroid dehydrogenase type 5 (AKR1C3), 17β-hydroxysteroid dehydrogenase type 2 (17βHSD2), 5α-reductase type 1 (SRD5A1) and 5α-reductase type 2 (SRD5A2), which catalyse prostate androgen metabolism, was investigated. The activities of both 17βHSD3 and AKR1C3 heterologously expressed in CHO-K1 and HEK293 cells were inhibited significantly by rooibos, with rooibos reducing the conversion of

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Kim, Byoungjin. "Intracellular metabolism of cancer cells and drug delivery using gold nanoparticles in an in vitro 3D tumor model." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/dissertations/AAI3359901/.

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Rodríguez-García, Ana. "PFKFB3: un gen clau en la reprogramació de les cèl·lules canceroses." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/523481.

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L’objectiu d’aquesta tesi doctoral és profunditzar en els mecanismes que fan de PFKFB3 un gen clau en la reprogramació metabòlica. En concret, s’estudia els mecanismes de connexió de la insulina i el TGF-β1 amb el metabolisme de la glucosa i PFKFB3 en les línies cel·lulars de carcinoma de colon (HT29) i glioblastoma multiforme (T98G), respectivament. PFKFB3 és un enzim bifuncional homodimèric que pertany a la família de la 6-fosfofructo-2-quinasa/fructosa-2,6- bisfosfatasa (PFK-2/FBPasa-2), que controla la conversió entre la fructosa-6-fosfat (Fru-6-P) a fructosa-2,6-bisfosfat (Fru-2,6-P2).

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Vianello, Caterina. "Innovative mitochondrial and metabolic targets to enhance cisplatin response: studies on cancer cells with acquired and intrinsic resistance." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425345.

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Cisplatin is one of the most potent anticancer agents used in the treatment of various solid tumors. Unfortunately the onset of resistance is the main limit of this therapy and severely compromises the treatment effectiveness. Although several studies regarding cisplatin resistance have been performed, the molecular mechanisms are not completely understood. Classically, cisplatin is studied as a DNA-damaging chemotherapy agent, but more recent investigations showed that only 5-10% of intracellular platinum is bound to nuclear DNA, while the great majority of the intracellular drug can interact

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Zodda, Erika. "Characterization of Endothelial Cells dysfunction associated to Acute Myocardial Infarction: modulation of metabolic pathways as a new therapeutic approach." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668403.

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The endothelium plays a pivotal role in the development of cardiovascular disease (CVD) and emerging evidence indicates that pathological blood vessel responses and endothelial dysfunction are associated with metabolic alterations in endothelial cells (ECs). This project aims at performing a complete characterization of the metabolic profiles of an endothelial pathological Acute Myocardial Infarction (AMI) model of 8 patients. The results discussed throughout this thesis are part of this attempt, and brought to the identification of the insights and causes of the AMI pathology, as a consequen

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Huichalaf, Carbonell Mariela [Verfasser], and Stefan [Akademischer Betreuer] Wölfl. "Metabolic Profiling of Cancer Cells and Correlations between Metabolism, Gene Expression and Drug Sensitivity / Mariela Huichalaf Carbonell ; Betreuer: Stefan Wölfl." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177383950/34.

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Deshmukh, Abhijeet Popatrao. "The Role of Secreted Frizzled-related Protein-4 (sFRP4) in the Epigenetics, Metabolism and Chemo-sensitisation of Cancer Stem Cells." Thesis, Curtin University, 2017. http://hdl.handle.net/20.500.11937/65388.

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This study investigated molecular signals involved in sustaining CSCs and ways to target their activity using sFRP4 alone or in combination with chemotherapeutic drugs, possible involvement of methylation-mediated silencing of the sFRP gene family, and metabolic reprogramming by relocating metabolic flux to glycolysis or oxidative phosphorylation. sFRPs have an ability to sensitize tumour cells to chemotherapeutic drugs, thereby enhancing cell death. Altogether, sFRP4 treatment compromises the cell proliferation, and critically affects the cell survival mechanisms of CSCs.

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Brown, Ashley Kaye. "Investigating the Effect of Energy Substrates and LPS-activation on the In Vitro Energy Metabolism of BV-2, RAW264.7 and VM-M3 Cells." Thesis, Boston College, 2016. http://hdl.handle.net/2345/bc-ir:106811.

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Thesis advisor: Thomas N. Seyfried<br>Two major metabolic phenomena observed in cancer cells include the Warburg effect and Crabtree effect. The Crabtree effect is the in vitro inhibition of respiration by glucose. The influence of glucose on the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of tumorigenic RAW264.7 and VM-M3 macrophage cells, as well as non-tumorigenic BV-2 microglia cells, was studied using the Seahorse XF96 extracellular flux analyzer. RAW264.7, VM-M3, and BV-2 cells incubated in glucose medium displayed a significantly lower OCR and higher ECAR c

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Alok, Kumar. "Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy." Kyoto University, 2020. http://hdl.handle.net/2433/254514.

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Simojoki, M. (Marja). "Type I and type III collagen metabolites and peritoneal cells in predicting the clinical outcome of epithelial ovarian cancer patients." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514269322.

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Abstract Malignant tissue growth induces marked biochemical and structural changes in the extracellular matrix of the tumour and its surrounding tissues. In the present study, we evaluated the prognostic value of the serum concentration of the markers of synthesis of type I collagen (PICP, PINP) and type III collagen (PIIINP) as well as the marker of type I collagen degradation (ICTP) and compared them with the conventional indicators of prognosis (clinical stage, grade of differentiation, histological subtype, residual tumour load and the age of the patient). The prognostic value of peritonea

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Wong, Ka Yeung Mark. "Drug clearance mechanisms and chemotherapy response." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28094.

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Cytotoxic chemotherapeutic agents have a major role in the treatment of cancers. However, many cytotoxic agents have a narrow therapeutic window with best treatment response achieved only within a small range of drug concentrations.

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Rainer, Roman Josef. "Identification of differential regulation in central carbon metabolism between related cell lines." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/22117.

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Darmkrebszellen und T-Zellen regulieren ihren zentralen Kohlenstoffmetabolismus um ihren anabolen Bedarf zu erfüllen. Tumorzellen mit einer KRAS- oder BRAF-Mutation zeigen ein schnelles Wachstum, welches eine Umprogrammierung des Metabolismus vor aussetzt. Der mitochondriale T-Zellen-Aktivierungsinhibitor (TCAIM) ist bekannt dafür die mitochondriale Zellstruktur zu beeinflussen. Der Einfluss auf den Metabolismus nicht klar. In dieser Arbeit präsentiere ich erstmalig ein mathematische Model des zentralen Kohlen stoffmetabolismus in Darmkrebszellen und T-Zellen. Mithilfe dieses Modells an

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