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Journal articles on the topic 'Cancer cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Fernández-Lázaro, Diego, César Ignacio Fernández-Lázaro, and Martínez Alfredo Córdova. "Cell Death: Mechanisms and Pathways in Cancer Cells." Cancer Medicine Journal 1, no. 1 (2018): 12–23. http://dx.doi.org/10.46619/cmj.2018.1-1003.

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Programmed cell death is an essential physiological and biological process for the proper development and functioning of the organism. Apoptosis is the term that describes the most frequent form of programmed cell death and derives from the morphological characteristics of this type of death caused by cellular suicide. Apoptosis is highly regulated to maintain homeostasis in the body, since its imbalances by increasing and decreasing lead to different types of diseases. In this review, we aim to describe the mechanisms of cell death and the pathways through apoptosis is initiated, transmitted,

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2

Srivastava, A. N., Neema Tiwari, Shailendra Yadav, and Suryakant . "LUNG CANCER STEM CELLS-AN UPDATE." Era's journal of medical research 4, no. 1 (2017): 22–31. http://dx.doi.org/10.24041/ejmr2017.4.

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3

MAS, Bezerra, Ferreira LAM, Kawasaki-Oyama RS, et al. "Effectiveness of Hypoxia-Induced Accumulation of Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma." Cancer Medicine Journal 3, S1 (2020): 13–23. http://dx.doi.org/10.46619/cmj.2020.3.s1-1003.

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INTRODUCTION: The small number of cancer stem cells, which correspond to only 0.01% - 0.1% of total tumor cells, has been the biggest obstacle in understanding their biology and role in the origin and maintenance of tumors, their metastatic and recurrence potentials, and resistance to radio-chemotherapy. Therefore, promoting its accumulation will enable further studies and future advances in the diagnosis and treatment of head and neck cancer squamous cell carcinoma. OBJECTIVE: To induce cancer stem cell accumulation in primary cell cultures of head and neck squamous cell carcinoma using a hyp

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Yin, Wen, Jialing Wang, Linling Jiang, and Y. James Kang. "Cancer and stem cells." Experimental Biology and Medicine 246, no. 16 (2021): 1791–801. http://dx.doi.org/10.1177/15353702211005390.

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Being the second leading cause of death globally, cancer has been a long-standing and rapidly evolving focus of biomedical research and practice in the world. A tremendous effort has been made to understand the origin of cancer cells, the formation of cancerous tissues, and the mechanism by which they spread and relapse, but the disease still remains mysterious. Here, we made an attempt to scrutinize evidences that indicate the role of stem cells in tumorigenesis and metastasis, and cancer relapse. We also looked into the influence of cancers on stem cells, which in turn represent a major cons

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Fujimoto, Naohiro, Bin Han, Masayoshi Nomura, and Tetsuro Matsumoto. "WS1-1-1 Nitrogen-Containing Bisphosphonates Inhibit the Growth of Renal Cell Carcinoma Cells(Renal Cell Cancer)." Japanese Journal of Urology 99, no. 2 (2008): 142. http://dx.doi.org/10.5980/jpnjurol.99.142_1.

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Pratap, Dr Pushpendra D. "CANCER STEM CELLS IN CERVICAL CANCER AS BENEFICIAL GOALS AND BIOMARKERS: A COMPREHENSIVE." Era's Journal of Medical Research 10, no. 2 (2023): 51–55. http://dx.doi.org/10.24041/ejmr2023.36.

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The fourth most prevalent gynaecological malignancy affecting females globally is cervical cancer (CC). HPV (high-risk) infection has been related to the majority of CC cases. Owing to efficient screening through Pap smear and vaccination delivery, the commonness and death rate of CC have significantly decreased. Nevertheless, not all societies have access to this equally. A better therapeutic outcome may be achieved by targeting CSCs, which might play a significant impact in carcinogenesis, metastasis, recurrence, and radio / chemo –resistance of CC. The majority of tumours are made up of a t

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Lee, Cheong J., Joseph Dosch, and Diane M. Simeone. "Pancreatic Cancer Stem Cells." Journal of Clinical Oncology 26, no. 17 (2008): 2806–12. http://dx.doi.org/10.1200/jco.2008.16.6702.

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Cellular heterogeneity in cancer was observed decades ago by studies in mice which showed that distinct subpopulations of cells within a tumor mass are capable of driving tumorigenesis. Conceptualized from this finding was the stem-cell hypothesis for cancer, which suggests that only a specific subset of cancer cells within each tumor is responsible for tumor initiation and propagation, termed tumor initiating cells or cancer stem cells (CSCs). Recent data has been provided to support the existence of CSCs in human blood cell–derived cancers and solid organ tumors of the breast, brain, prostat

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Inderberg, Else Marit, and Sébastien Wälchli. "T cells successfully fighting cancer." Open Access Government 43, no. 1 (2024): 84–85. http://dx.doi.org/10.56367/oag-043-11536.

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T cells successfully fighting cancer Else Marit Inderberg and Sébastien Wälchli from Oslo University Hospital explore what we need to know about T cells successfully fighting cancer. Cell-based immunotherapy uses the patient’s own immune cells to target and kill cancer cells in a specific manner. Lymphocytes called T cells are mainly used for this type of therapy, and to target them more efficiently against cancer cells, they are genetically modified to express chimeric antigen receptors (CAR) or T cell receptors (TCR) that bind proteins or peptides presented on the surface of cancer cells. Th

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Moorthy, Rajesh Kannan, Chandhru Srinivasan, Sridharan Jayamohan, et al. "Knockdown of microRNA-375 suppresses cell proliferation and promotes apoptosis in human breast cancer cells." Indian Journal of Science and Technology 14, no. 43 (2021): 3199–209. http://dx.doi.org/10.17485/ijst/v14i43.1719.

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10

Logtenberg, Meike E. W., and Johannes Boonstra. "Cancer stem cells and addicted cancer cells." Oncology Discovery 1, no. 1 (2013): 7. http://dx.doi.org/10.7243/2052-6199-1-7.

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11

Reya, Tannishtha, Sean J. Morrison, Michael F. Clarke, and Irving L. Weissman. "Stem cells, cancer, and cancer stem cells." Nature 414, no. 6859 (2001): 105–11. http://dx.doi.org/10.1038/35102167.

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12

Pecqueur, Claire, Lisa Oliver, Kristell Oizel, Lisenn Lalier, and François M. Vallette. "Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells." International Journal of Cell Biology 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/805975.

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Abnormal metabolism and the evasion of apoptosis are considered hallmarks of cancers. Accumulating evidence shows that cancer stem cells are key drivers of tumor formation, progression, and recurrence. A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes.

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Elgaly, Maher E., Mohamed E. El Ghareeb, and Farha El shennawy. "Cord Blood Mesenchymal Stem Cells Conditioned Media Suppress Epithelial Ovarian Cancer Cells in Vitro." International Journal of Trend in Scientific Research and Development Volume-2, Issue-5 (2018): 1783–88. http://dx.doi.org/10.31142/ijtsrd18182.

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14

SK, Deshmukh. "Immune Cells in the Tumor Microenvironment and Cancer Stem Cells: Interplay for Tumor Progression." Journal of Embryology & Stem Cell Research 2, no. 2 (2018): 1–2. http://dx.doi.org/10.23880/jes-16000109.

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15

KOCHIN, Vitaly, Takayuki KANASEKI, Daiichi MOROOKA, et al. "P4-006 Natural peptidome presented by HLA-A24 of cancer and cancer stem cells." Japanese Journal of Clinical Immunology 37, no. 4 (2014): 348b. http://dx.doi.org/10.2177/jsci.37.348b.

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16

Takaishi, Shigeo, Tomoyuki Okumura, and Timothy C. Wang. "Gastric Cancer Stem Cells." Journal of Clinical Oncology 26, no. 17 (2008): 2876–82. http://dx.doi.org/10.1200/jco.2007.15.2603.

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Cancer stem cells are defined as the unique subpopulation in the tumors that possess the ability to initiate tumor growth and sustain self-renewal as well as metastatic potential. Accumulating evidence in recent years strongly indicate the existence of cancer stem cells in solid tumors of a wide variety of organs. In this review, we will discuss the possible existence of a gastric cancer stem cell. Our recent data suggest that a subpopulation with a defined marker shows spheroid colony formation in serum-free media in vitro, as well as tumorigenic ability in immunodeficient mice in vivo. We wi

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17

Afify, Chen, Yan, et al. "Method to Convert Stem Cells into Cancer Stem Cells." Methods and Protocols 2, no. 3 (2019): 71. http://dx.doi.org/10.3390/mps2030071.

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The cancer stem cell (CSC) hypothesis suggests that tumors are sustained exclusively by a small population of the cells with stem cell properties. CSCs have been identified in most tumors and are responsible for the initiation, recurrence, and resistance of different cancers. In vitro CSC models will be of great help in revisiting the mechanism of cancer development, as well as the tumor microenvironment and the heterogeneity of cancer and metastasis. Our group recently described the generation of CSCs from induced pluripotent stem cells (iPSCs), which were reprogrammed from normal cells, and/

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18

Michor, Franziska. "Mathematical Models of Cancer Stem Cells." Journal of Clinical Oncology 26, no. 17 (2008): 2854–61. http://dx.doi.org/10.1200/jco.2007.15.2421.

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Human cancers are thought to be sustained in their growth by a pathologic counterpart of normal adult stem cells: cancer stem cells. This concept was first developed in human myeloid leukemias and is today being extended to solid tumors such as breast and brain cancers. A quantitative understanding of cancer stem cells requires a mathematical framework to describe the dynamics of cancer initiation and progression, the response to treatment, and the evolution of resistance. In this review, I use chronic myeloid leukemia as an example to discuss how mathematical and computational techniques have

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19

Kiberstis, P. A. "CANCER: Reprogramming Cancer Cells." Science 305, no. 5688 (2004): 1214a. http://dx.doi.org/10.1126/science.305.5688.1214a.

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20

S, Tanabe. "Molecular Markers and Networks for Cancer and Stem Cells." Journal of Embryology & Stem Cell Research 1, no. 1 (2017): 1–13. http://dx.doi.org/10.23880/jes-16000101.

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21

Balzanelli, Mario G., Pietro Distratis, Rita Lazzaro, et al. "From Pathogens to Cancer: Are Cancer Cells Evolved Mitochondrial Super Cells?" Diagnostics 13, no. 4 (2023): 813. http://dx.doi.org/10.3390/diagnostics13040813.

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Life is based on a highly specific combination of atoms, metabolism, and genetics which eventually reflects the chemistry of the Universe which is composed of hydrogen, oxygen, nitrogen, sulfur, phosphorus, and carbon. The interaction of atomic, metabolic, and genetic cycles results in the organization and de-organization of chemical information of that which we consider as living entities, including cancer cells. In order to approach the problem of the origin of cancer it is therefore reasonable to start from the assumption that the sub-molecular level, the atomic structure, should be the con

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22

Liu, Suling, and Max S. Wicha. "Targeting Breast Cancer Stem Cells." Journal of Clinical Oncology 28, no. 25 (2010): 4006–12. http://dx.doi.org/10.1200/jco.2009.27.5388.

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There is increasing evidence that many cancers, including breast cancer, contain populations of cells that display stem-cell properties. These breast cancer stem cells, by virtue of their relative resistance to radiation and cytotoxic chemotherapy, may contribute to treatment resistance and relapse. The elucidation of pathways that regulate these cells has led to the identification of potential therapeutic targets. A number of agents capable of targeting breast cancer stem cells in preclinical models are currently entering clinical trials. Assessment of the efficacy of the agents will require

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23

Caneba, Christine A., Nadège Bellance, Lifeng Yang, Lisa Pabst, and Deepak Nagrath. "Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration." American Journal of Physiology-Endocrinology and Metabolism 303, no. 8 (2012): E1036—E1052. http://dx.doi.org/10.1152/ajpendo.00151.2012.

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Anoikis resistance, or the ability for cells to live detached from the extracellular matrix, is a property of epithelial cancers. The “Warburg effect,” or the preference of cancer cells for glycolysis for their energy production even in the presence of oxygen, has been shown to be evident in various tumors. Since a cancer cell's metastatic ability depends on microenvironmental conditions (nutrients, stromal cells, and vascularization) and is highly variable for different organs, their cellular metabolic fluxes and nutrient demand may show considerable differences. Moreover, a cancer cell's met

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24

Gedye, Craig, Adee-Jonathan Davidson, Martin R. Elmes, Jonathan Cebon, Damien Bolton, and Ian D. Davis. "Cancer stem cells in urologic cancers." Urologic Oncology: Seminars and Original Investigations 28, no. 6 (2010): 585–90. http://dx.doi.org/10.1016/j.urolonc.2009.06.010.

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25

Møller, Trine, Jaslin P. James, Kim Holmstrøm, Flemming B. Sørensen, Jan Lindebjerg та Boye S. Nielsen. "Co-Detection of miR-21 and TNF-α mRNA in Budding Cancer Cells in Colorectal Cancer". International Journal of Molecular Sciences 20, № 8 (2019): 1907. http://dx.doi.org/10.3390/ijms20081907.

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MicroRNA-21 (miR-21) is upregulated in many cancers including colon cancers and is a prognostic indicator of recurrence and poor prognosis. In colon cancers, miR-21 is highly expressed in stromal fibroblastic cells and more weakly in a subset of cancer cells, particularly budding cancer cells. Exploration of the expression of inflammatory markers in colon cancers revealed tumor necrosis factor alpha (TNF-α) mRNA expression at the invasive front of colon cancers. Surprisingly, a majority of the TNF-α mRNA expressing cells were found to be cancer cells and not inflammatory cells. Because miR-21

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26

Krishnamurthy, S., and J. E. Nör. "Head and Neck Cancer Stem Cells." Journal of Dental Research 91, no. 4 (2011): 334–40. http://dx.doi.org/10.1177/0022034511423393.

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Most cancers contain a small sub-population of cells that are endowed with self-renewal, multipotency, and a unique potential for tumor initiation. These properties are considered hallmarks of cancer stem cells. Here, we provide an overview of the field of cancer stem cells with a focus on head and neck cancers. Cancer stem cells are located in the invasive fronts of head and neck squamous cell carcinomas (HNSCC) close to blood vessels (perivascular niche). Endothelial cell-initiated signaling events are critical for the survival and self-renewal of these stem cells. Markers such as aldehyde d

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27

Dyall, Sheetal, Simon A. Gayther, and Dimitra Dafou. "Cancer Stem Cells and Epithelial Ovarian Cancer." Journal of Oncology 2010 (2010): 1–9. http://dx.doi.org/10.1155/2010/105269.

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The cancer stem cell hypothesis is becoming more widely accepted as a model for carcinogenesis. Tumours are heterogeneous both at the molecular and cellular level, containing a small population of cells that possess highly tumourigenic “stem-cell” properties. Cancer stem cells (CSCs), or tumour-initiating cells, have the ability to self-renew, generate xenografts reminiscent of the primary tumour that they were derived from, and are chemoresistant. The characterisation of the CSC population within a tumour that drives its growth could provide novel target therapeutics against these cells speci

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Runel, Gaël, Noémie Lopez-Ramirez, Julien Chlasta, and Ingrid Masse. "Biomechanical Properties of Cancer Cells." Cells 10, no. 4 (2021): 887. http://dx.doi.org/10.3390/cells10040887.

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Since the crucial role of the microenvironment has been highlighted, many studies have been focused on the role of biomechanics in cancer cell growth and the invasion of the surrounding environment. Despite the search in recent years for molecular biomarkers to try to classify and stratify cancers, much effort needs to be made to take account of morphological and nanomechanical parameters that could provide supplementary information concerning tissue complexity adaptation during cancer development. The biomechanical properties of cancer cells and their surrounding extracellular matrix have act

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29

Nunes, Toni, Diaddin Hamdan, Christophe Leboeuf, et al. "Targeting Cancer Stem Cells to Overcome Chemoresistance." International Journal of Molecular Sciences 19, no. 12 (2018): 4036. http://dx.doi.org/10.3390/ijms19124036.

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Cancers are heterogeneous at the cell level, and the mechanisms leading to cancer heterogeneity could be clonal evolution or cancer stem cells. Cancer stem cells are resistant to most anti-cancer treatments and could be preferential targets to reverse this resistance, either targeting stemness pathways or cancer stem cell surface markers. Gold nanoparticles have emerged as innovative tools, particularly for photo-thermal therapy since they can be excited by laser to induce hyperthermia. Gold nanoparticles can be functionalized with antibodies to specifically target cancer stem cells. Preclinic

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Ding, Shijie, Chunbao Li, Ninghui Cheng, Xiaojiang Cui, Xinglian Xu, and Guanghong Zhou. "Redox Regulation in Cancer Stem Cells." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/750798.

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Reactive oxygen species (ROS) and ROS-dependent (redox regulation) signaling pathways and transcriptional activities are thought to be critical in stem cell self-renewal and differentiation during growth and organogenesis. Aberrant ROS burst and dysregulation of those ROS-dependent cellular processes are strongly associated with human diseases including many cancers. ROS levels are elevated in cancer cells partially due to their higher metabolism rate. In the past 15 years, the concept of cancer stem cells (CSCs) has been gaining ground as the subpopulation of cancer cells with stem cell-like

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31

Papaccio, Federica, Francesca Paino, Tarik Regad, Gianpaolo Papaccio, Vincenzo Desiderio, and Virginia Tirino. "Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development." STEM CELLS Translational Medicine 6, no. 12 (2017): 2115–25. http://dx.doi.org/10.1002/sctm.17-0138.

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32

Sucharitha, Are. "An Overview of Cancer." Advances in Cancer Chemotherapy and Pharmacology 1, no. 1 (2023): 1–8. http://dx.doi.org/10.23880/accp-16000102.

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Cancer is defined as one of the large groups of diseases characterized by the development of abnormal cells that grow beyond their boundaries, which can invade adjoining tissues via circulation, and spread to other organs in the body. Cancer can be initiated anywhere in the body, where damaged cells grow and multiply where they shouldn't. These cells form tumors, also called neoplasm- an abnormal mass of cells. Tumors can be non-cancerous (benign) and cancerous (malignant). Cancers are grouped according to their origin of tissue or organ. Four major types of cancers- • Carcinomas – are maligna

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33

Tavartkiladze, Alexandre, Revaz Turmanidze, Gaiane Simonia, et al. "Circulating Tumor Cells and cfDNA: Key Predictive Biomarkers in Non - Small Cell Lung Cancer Progression and Treatment." International Journal of Science and Research (IJSR) 12, no. 10 (2023): 1078–81. http://dx.doi.org/10.21275/sr231013031834.

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34

Kobayashi, Hisataka, Aki Furusawa, Adrian Rosenberg, and Peter L. Choyke. "Near-infrared photoimmunotherapy of cancer: a new approach that kills cancer cells and enhances anti-cancer host immunity." International Immunology 33, no. 1 (2020): 7–15. http://dx.doi.org/10.1093/intimm/dxaa037.

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Abstract Near-infrared photoimmunotherapy (NIR-PIT) is a recently developed hybrid cancer therapy that directly kills cancer cells as well as producing a therapeutic host immune response. Conventional immunotherapies, such as immune-activating cytokine therapy, checkpoint inhibition, engineered T cells and suppressor cell depletion, do not directly destroy cancer cells, but rely exclusively on activating the immune system. NIR-PIT selectively destroys cancer cells, leading to immunogenic cell death that initiates local immune reactions to released cancer antigens from dying cancer cells. These

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35

Koliaraki, Vasiliki, Charles K. Pallangyo, Florian R. Greten, and George Kollias. "Mesenchymal Cells in Colon Cancer." Gastroenterology 152, no. 5 (2017): 964–79. https://doi.org/10.5281/zenodo.2576752.

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Mesenchymal cells in the intestine comprise a variety of cell types of diverse origins, functions, and molecular markers. They provide mechanical and structural support and have important functions during intestinal organogenesis, morphogenesis, and homeostasis. Recent studies of the human transcriptome have revealed their importance in the development of colorectal cancer, and studies from animal models have provided evidence for their roles in the pathogenesis of colitis-associated cancer and sporadic colorectal cancer. Mesenchymal cells in tumors, called cancer-associated fibroblasts, arise

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36

Zecchin, Annalisa, Gitte Borgers, and Peter Carmeliet. "Endothelial cells and cancer cells." Current Opinion in Hematology 22, no. 3 (2015): 234–42. http://dx.doi.org/10.1097/moh.0000000000000138.

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37

Subramaniam, Dharmalingam, Gaurav Kaushik, Prasad Dandawate, and Shrikant Anant. "Targeting Cancer Stem Cells for Chemoprevention of Pancreatic Cancer." Current Medicinal Chemistry 25, no. 22 (2018): 2585–94. http://dx.doi.org/10.2174/0929867324666170127095832.

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Pancreatic ductal adenocarcinoma is one of the deadliest cancers worldwide and the fourth leading cause of cancer-related deaths in United States. Regardless of the advances in molecular pathogenesis and consequential efforts to suppress the disease, this cancer remains a major health problem in United States. By 2030, the projection is that pancreatic cancer will be climb up to be the second leading cause of cancer-related deaths in the United States. Pancreatic cancer is a rapidly invasive and highly metastatic cancer, and does not respond to standard therapies. Emerging evidence supports th

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Yue, Fengming, Kanji Hirashima, Daihachiro Tomotsune, Sakiko Takizawa-Shirasawa, Tadayuki Yokoyama, and Katsunori Sasaki. "Reprogramming of retinoblastoma cancer cells into cancer stem cells." Biochemical and Biophysical Research Communications 482, no. 4 (2017): 549–55. http://dx.doi.org/10.1016/j.bbrc.2016.11.072.

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Kadhim, Shahd Abdulamer. "Purpose of Intracellular Communication Connexin 43 in Breast Cancer Cells." International Journal of Psychosocial Rehabilitation 24, no. 4 (2020): 3910–15. http://dx.doi.org/10.37200/ijpr/v24i4/pr201503.

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40

Aguilar-Gallardo, Cristóbal, and Carlos Simón. "Cells, Stem Cells, and Cancer Stem Cells." Seminars in Reproductive Medicine 31, no. 01 (2013): 005–13. http://dx.doi.org/10.1055/s-0032-1331792.

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41

Shang, Zhiyang, Yingxin Xu, Wentao Liang, et al. "Isolation of cancer progenitor cells from cancer stem cells in gastric cancer." Molecular Medicine Reports 15, no. 6 (2017): 3637–43. http://dx.doi.org/10.3892/mmr.2017.6423.

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42

Bodmer, Walter, and Vita Golubovskaya. "Cancer Immunotherapy: Where Next?" Cancers 15, no. 8 (2023): 2358. http://dx.doi.org/10.3390/cancers15082358.

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The fundamental problem of dealing with cancer is that cancer cells are so like normal cells that it is very hard to find differences that can be a basis for treatment without severe side effects. The key to successful cancer immunotherapy will be based on a very careful choice of cancer targets that are sufficiently cancer specific not to cause serious side effects. There are two fundamentally different ways to deploy the immune system for such cancer treatments. One is to increase the efficacy of the cancer patient’s own immune system so that it attacks these differences. This has been achie

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Barbato, Luisa, Marco Bocchetti, Anna Di Biase, and Tarik Regad. "Cancer Stem Cells and Targeting Strategies." Cells 8, no. 8 (2019): 926. http://dx.doi.org/10.3390/cells8080926.

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Chemoresistance is a major problem in cancer therapy as cancer cells develop mechanisms that counteract the effect of chemotherapeutic compounds, leading to relapse and the development of more aggressive cancers that contribute to poor prognosis and survival rates of treated patients. Cancer stem cells (CSCs) play a key role in this event. Apart from their slow proliferative property, CSCs have developed a range of cellular processes that involve drug efflux, drug enzymatic inactivation and other mechanisms. In addition, the microenvironment where CSCs evolve (CSC niche), effectively contribut

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Apriani, Riza, and Fajar Fauzi Abdullah. "Cytotoxic Activity of Ethyl-para-methoxycinnamate from Kaempferia galanga L. on A549 Lung Cancer and B16 Melanoma Cancer Cells." Jurnal Kimia Sains dan Aplikasi 24, no. 1 (2020): 22–28. http://dx.doi.org/10.14710/jksa.24.1.22-28.

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Kaempferia galanga L. belongs to the family of Zingiberaceae, an endangered medicinal plant with pharmacology activities. Ethyl-p-methoxycinnamate (EPMC) is an essential phytoconstituent of K. galanga rhizomes. Several studies have reported that EPMC has anticancer activities in several cancer cells, including CL-6 gallbladder cancer cells, HepG2liver cancer cells, MCF-7 breast cancer cells, and Raji lymphoma cancer cells. However, studies on A549 lung cancer and B16 melanoma cancer cells have not been reported. This study aimed to determine the anticancer activity of EPMC against A549 lung ca

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Franzè, Eleonora, Carmine Stolfi, Edoardo Troncone, Patrizio Scarozza, and Giovanni Monteleone. "Role of Interleukin-34 in Cancer." Cancers 12, no. 1 (2020): 252. http://dx.doi.org/10.3390/cancers12010252.

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Cross-talk between cancer cells and the immune cells occurring in the tumor microenvironment is crucial in promoting signals that foster tumor growth and metastasis. Both cancer cells and immune cells secrete various interleukins (IL), which, either directly or indirectly, stimulate cancer-cell proliferation, survival, and diffusion, as well as contribute to sculpt the immune microenvironment, thereby amplifying tumorigenic stimuli. IL-34, a cytokine produced by a wide range of cells, has been initially involved in the control of differentiation, proliferation, and survival of myeloid cells. M

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Hubbard, Joleen M., and Axel Grothey. "Cancer Stem Cells and Cancer Stem Cell Inhibitors in Gastrointestinal Cancers." Oncology & Hematology Review (US) 12, no. 01 (2016): 41. http://dx.doi.org/10.17925/ohr.2016.12.01.41.

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Cancer stem cells (CSCs) are a subpopulation of phenotypically distinct cancer cells that may play an important role in tumor pathogenesis. The gastrointestinal (GI) system provides a good example for investigation of the role of CSCs in tumor proliferation; GI CSCs are suitable for study due to their abundance, proliferative potential, and consistent structural arrangement that is maintained under tightly controlled signaling pathways. GI stem cells have a long lifespan and this, combined with their rapid turnover, may predispose them to forming CSCs. Alternative possible sources of GI CSCs i

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Munro, Matthew J., Susrutha K. Wickremesekera, Lifeng Peng, Swee T. Tan, and Tinte Itinteang. "Cancer stem cells in colorectal cancer: a review." Journal of Clinical Pathology 71, no. 2 (2017): 110–16. http://dx.doi.org/10.1136/jclinpath-2017-204739.

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Colorectal cancer (CRC) is the second most common cancer in women and the third most common in men. Adenocarcinoma accounts for 90% of CRC cases. There has been accumulating evidence in support of the cancer stem cell (CSC) concept of cancer which proposes that CSCs are central in the initiation of cancer. CSCs have been the focus of study in a range of cancers, including CRC. This has led to the identification and understanding of genes involved in the induction and maintenance of pluripotency of stem cells, and markers for CSCs, including those investigated specifically in CRC. Knowledge of

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Xu, Jiasheng, Kaili Liao, and Weimin Zhou. "Exosomes Regulate the Transformation of Cancer Cells in Cancer Stem Cell Homeostasis." Stem Cells International 2018 (September 23, 2018): 1–16. http://dx.doi.org/10.1155/2018/4837370.

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In different biological model systems, exosomes are considered mediators of cell-cell communication between different cell populations. Exosomes, as extracellular vesicles, participate in physiological and pathological processes by transmitting signaling molecules such as proteins, nucleic acids, and lipids. The tumor’s microenvironment consists of many types of cells, including cancer stem cells and mesenchymal cells. It is well known that these cells communicate with each other and thereby regulate the progression of the tumor. Recent studies have provided evidence that exosomes mediate the

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Yasuda, K., M. Yashiro, T. Sawada, M. Ohira, and K. Hirakawa. "Clinical significance of ERas oncogene on cancer." Journal of Clinical Oncology 25, no. 18_suppl (2007): 15083. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.15083.

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15083 Background: Embryonic stem (ES) cells are pluripotent cells derived from early mammalian embryos. When ES cells are subcutaneously injected into immunodeficient or isogenic mice, a teratoma is formed within a few weeks. This tumor is composed of all three germ layers in a disorganized fashion. Thus there could be some common molecular mechanisms shared by ES cells and somatic cancer cells. The ERas oncogene is a recently identified gene that supports the tumorigenic growth of ES cells by producing a constitutively active Ras protein. There have been no report about expression of ERas onc

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Walter, Karolin, Kanishka Tiwary, Marija Trajkovic-Arsic, et al. "MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo." Stem Cells International 2019 (June 2, 2019): 1–11. http://dx.doi.org/10.1155/2019/8475389.

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Pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease with a very poor prognosis. At the same time, its incidence is on the rise, and PDAC is expected to become the second leading cause of cancer-related death by 2030. Despite extensive work on new therapeutic approaches, the median overall survival is only 6-12 months after diagnosis and the 5-year survival is less than 7%. While pancreatic cancer is particularly difficult to treat, patients usually succumb not to the growth of the primary tumor, but to extensive metastasis; therefore, strategies to reduce the migratory and me

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