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Dissertations / Theses on the topic 'Cancer Enzymes'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Gunnarsson, Cecilia. "Steroid converting enzymes in breast cancer /." Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med908s.pdf.

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2

Ardiani, Andressa. "Engineering novel suicide enzymes for improved cancer gene therapy." Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Dissertations/Spring2009/A_Ardiani_050609.pdf.

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3

McKay, Judith A. "The expression of xenobiotic metabolising enzymes in human tumours." Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU078740.

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The cytochromes P450 (CYPs), epoxide hydrolases (EHs) and glutathione S-transferases (GSTs) are three of the major families of enzymes involved in the metabolism of xenobiotics in the human body. Immunohistochemical analysis revealed a high frequency of expression of xenobiotic metabolising enzymes in all tumour types studied, in contrast to corresponding normal tissue which displayed only low levels of expression. Further examination of the CYP1 family was carried out by immunoblot analysis. All breast tumours studied were found to express CYP1B1, and not CYP1A1 or CYP1A2. Moreover, CYP1B1 wa

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4

Willmon, Candice Lynn. "Engineering enhanced enzymes for suicide gene therapy of cancer." Online access for everyone, 2006. http://www.dissertations.wsu.edu/Dissertations/Spring2006/c%5Fwillmon%5F050206.pdf.

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5

Min, Junxia. "Sphingolipid metabolic enzymes modulate anticancer drug resistance." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/5899.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (March 5, 2007) Vita. Includes bibliographical references.

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6

Wendum, Dominique. "Enzymes du métabolisme des eicosanoïdes et tumorigenèse colorectale et intestinale." Paris 6, 2004. http://www.theses.fr/2004PA066336.

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7

RICH, WENDY LEA. "Interrelationships Of The Estrogen-Producing Enzymes Network In Breast Cancer." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1230581012.

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8

Marques, Carlos António Pascoal. "Study of tRNA modifying enzymes and codon usage bias in cancer." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/16040.

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Mestrado em Biologia Molecular e Celular<br>Recent evidences indicate that tRNA modifications and tRNA modifying enzymes may play important roles in complex human diseases such as cancer, neurological disorders and mitochondrial-linked diseases. We postulate that expression deregulation of tRNA modifying enzymes affects the level of tRNA modifications and, consequently, their function and the translation efficiency of their tRNA corresponding codons. Due to the degeneracy of the genetic code, most amino acids are encoded by two to six synonymous codons. This degeneracy and the biased usage of

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9

Ashtekar, Amruta Ashtekar. "A role for mitochondrial enzymes SDH and SOD2 in thyroid cancer." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu152355138828804.

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10

Mitchell, Irene Patricia. "Clinical, cellular and molecular aspects of carbohydrate metabolising enzymes in human tissues." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294109.

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11

Dive, C. "Flow cytoenzymology with special reference to cancer chemotherapy." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384585.

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12

Sandri, Maria Ines. "Studies of the expression and regulation of topoisomerase II." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364213.

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13

Segersten, Ulrika. "Vitamin D Hydroxylating Enzymes and Analogues in Parathyroid Tumors and Breast Cancer." Doctoral thesis, Uppsala University, Department of Surgical Sciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6008.

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<p>In hyperparathyroidism (HPT) raised serum concentrations of ionized calcium is caused by increased secretion of parathyroid hormone (PTH) by parathyroid tumors. Active vitamin D, 1α,25-dihydroxyvitamin D<sub>3</sub>, is known to suppress PTH secretion and to reduce proliferation of parathyroid tumor cells.</p><p>The aim of this thesis was to examine expression of vitamin D hydroxylating enzymes, regulating the activation and inactivation of vitamin D and to study effects of vitamin D analogues, in parathyroid tumors and breast cancer.</p><p>The vitamin D activating enzyme, CYP27B1/25-hydrox

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14

Söderström, Torbjörn. "Molecular endocrinology of target enzymes in androgen metabolism : implications for prostate cancer /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-89428-12-9/.

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15

Ramsey, Hollie-Alexandra. "Characterisation of deubiquitinase enzymes involved in androgen receptor regulation in prostate cancer." Thesis, University of Newcastle Upon Tyne, 2012. http://hdl.handle.net/10443/1509.

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The androgen receptor (AR) is a key transcription factor in prostate cancer (CaP) growth and metastases, and is the main target for CaP treatment via the use of anti-hormonal therapies. Unfortunately, this treatment is only effective in the short-term and re-growth of the tumour results in most cases, termed castrate-resistant CaP (CRCaP), this is refractory to additional chemotherapies and hence fatal. Expression and reactivation of the AR is commonly seen in CRCaP and acts as a driver of advanced CaP growth suggesting the receptor remains a suitable target for next generation CaP therapies.

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16

Mohmmad, Kareem Shokrea Ali. "The genetic modification of enzymes towards an anti-cancer prodrug activation system." Thesis, Bangor University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664600.

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Cancer is the most common cause of death worldwide and therefore attracts significant research attention. Directed enzyme-pro drug therapy offers a selective approach which can kill tumour cells whilst limiting the damage to healthy cells. Nitroreductases have potential applications in enzyme/prodrug targeted anti-cancer therapies due to their ability to convert the nontoxic prodrug CB 1954 into a cytotoxic drug that kills malignant cells. E. coli NfsB nitroreductase/CB 1954 has previously been studied but the low affinity of this enzyme for CB 1954 and its poor catalytic efficiency has thus f

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17

Veliça, Pedro Miguel do Nascimento. "Comparison of human and mouse AKR1C enzymes : implications for modeling human cancer." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/879/.

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Human aldo-keto reductases (AKR) of the 1C subfamily have been implicated in the progression of prostate, breast and endometrial carcinomas as well as leukaemias due to their ability to modify key signaling molecules: steroid hormones and prostaglandins (PGs). In leukaemia, the AKR1C3 isoform has been identified as a novel therapeutic target since its PGD2 reductase activity prevents cell differentiation. Mice are ideal organisms for in vivo studies, using knock-out or over-expression strains. However, no mouse models for AKR1C enzymes have been generated to date since the functional conservat

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18

White, James. "A kinetic study of the behaviour of plasminogen activating enzymes towards synthetic substrates." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235843.

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19

Weaver, M. R. "Studies of human serum galactosyltransferases." Thesis, University of Newcastle Upon Tyne, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378899.

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20

Hobbs, Jeanette Roseanna. "Structural studies on the DNA binding modes of topoisomerase poisons." Thesis, University of Reading, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342117.

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21

Turner, Janet Elizabeth. "Assessment of microbial enzymes for use in the determination of catecholamine metabolites in urine." Thesis, Open University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282315.

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22

Bamber, Dianne Elizabeth. "Polymorphism in loci encoding detoxyfying enzymes : its role in cancer susceptibility and outcome." Thesis, Keele University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246867.

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23

Facista, Alexander, Huy Nguyen, Cristy Lewis, et al. "Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer." BioMed Central, 2012. http://hdl.handle.net/10150/610153.

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BACKGROUND:Cancers often arise within an area of cells (e.g. an epithelial patch) that is predisposed to the development of cancer, i.e. a "field of cancerization" or "field defect." Sporadic colon cancer is characterized by an elevated mutation rate and genomic instability. If a field defect were deficient in DNA repair, DNA damages would tend to escape repair and give rise to carcinogenic mutations.PURPOSE:To determine whether reduced expression of DNA repair proteins Pms2, Ercc1 and Xpf (pairing partner of Ercc1) are early steps in progression to colon cancer.RESULTS:Tissue biopsies were ta

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24

Tillotson, Joseph, and Joseph Tillotson. "Targeting Enzymes Involved in Protein Translation and Quality Control as Potential Cancer Therapeutics." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621777.

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Activation of pathways resulting in an overexpression of oncoproteins, reliant on cap-dependent translation, or mutations of key proteins in a pathway can be advantageous to cancer cells but creates heightened protein quality control pressure. Because of this, there has been an interest in targeting enzymes involved in protein synthesis and protein quality control: such as the eukaryotic initiation factor, eIF4A, a DEAD-box RNA helicase involved in translation initiation, and p97, an AAA+ chaperone involved in protein quality control. Despite some successes in discovering both eIF4A and p97 in

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25

Palmebäck, Wegman Pia. "Studies of tamoxifen resistance in breast cancer." Doctoral thesis, Linköpings universitet, Cellbiologi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8943.

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Oestrogen is one of the most important hormonal regulators and is known to play a key role in the development and growth of breast cancer. The majority of tumours have a hormone dependent growth, and this is indicated by the presence of oestrogen receptors (ERs). About two thirds of breast cancers occur after the menopause when the ovaries have ceased to produce oestrogen and despite the low levels of circulating oestrogen’s the tumour concentrations of oestrone, oestradiol and their sulfates have been shown to be significant. Patients with hormone dependent tumours are candidates for treatmen

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26

Xintaropoulou, Chrysi. "Targeting aerobic glycolysis in breast and ovarian cancer." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29525.

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Cancer cells, unlike normal tissue, frequently rely on glycolysis for the production of energy and the metabolic intermediates required for their growth regardless of cellular oxygenation levels. This metabolic reconfiguration, termed the Warburg effect, provides a potential strategy to preferentially target tumours from a therapeutic perspective. The present study sought to investigate the glycolytic phenotype of breast and ovarian cancer, and assess the possibility of exploiting several glycolytic targets therapeutically. Initially the growth dependency of breast and ovarian cancer cells on

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27

Sacco, Joseph J. T. "Investigating roles for the deubiquitylating enzymes in the PtdIns3-K/PKB pathway in cancer." Thesis, University of Liverpool, 2012. http://livrepository.liverpool.ac.uk/11893/.

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Phosphatidylinositol 3-kinase (PtdIns3-K) signalling is a crucial survival pathway in multiple malignancies, and an exciting target for drug development. The pathway is subject to multiple regulatory mechanisms including ubiquitylation, a reversible process that can influence protein stability, localisation and activity. A family of approximately 80 deubiquitylating enzymes (DUBs) are responsible for the cleavage of ubiquitin and ubiquitin chains from protein substrates. The DUBs are attractive drug targets and have increasingly been implicated in cellular processes germane to malignancy, incl

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28

Delgoda, Rupika. "A study of arylamine N-acetyltransferase from Salmonella typhimurium." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302221.

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29

Collins, Hilary M. "The role of matrix metalloproteinases, their activators and inhibitors in colorectal tumourigenesis." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342046.

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30

Giersing, Birgitte Karin. "An agent for imaging matrix metalloproteinases." Thesis, University of Kent, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324715.

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31

Raleigh, S. M. "Involvement of cytochromes P450 (CYP) and other haem associated enzymes in the bioreduction of AQ4N, an antitumour prodrug." Thesis, De Montfort University, 1998. http://hdl.handle.net/2086/10713.

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The anthraquinone di-N-oxide AQ4N is a prodrug designed to be excluded from cell nuclei until metabolised in hypoxic tumour regions to AQ4, a DNA binder and potent inhibitor of topoisomerase II. The antitumour effects of AQ4N in rodent neoplasms are well characterised but the identity of enzymes responsible for the metabolism are unknown. The aims of the present work were to identify Cytochrome P450 (CYP) enzymes responsible for AQ4N metabolism in rat and human tissue and to conduct a preliminary investigation into the in vivo metabolism of AQ4N in tumour bearing rodents. AQ4N was found to und

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32

Stone, Helen Rosemary. "Characterisation of two deubiquitinating enzymes in the DNA damage response and replication." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6317/.

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Ub has an essential role within the DNA double strand break (DSB) response which is well documented. However the role of ubiquitin (Ub) in the regulation of replication is an emerging area of research. This thesis investigates how two deubiquitinating enzymes (DUBs), POH1 and USP50, regulate DSB repair and replication respectively. A screen of 103 siRNAs against putative DUBs in the human genome, measuring the amount of conjugated Ub after release from HU-induced damage, identified the proteasome associated DUB, POH1 as being important in regulating Ub-conjuagtes after damage. Further work fou

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33

Yengi, Lilian Gambo. "Polymorphism at loci encoding detoxifying enzymes : influence on susceptibility to cancer and inflammatory mediated pathologies." Thesis, Staffordshire University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242066.

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34

Hamdi, Yosr. "Interactions entre les gènes des enzymes antioxydantes et leurs relations avec le cancer du sein." Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25881/25881.pdf.

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35

Ulrich, Cornelia Maren. "Common polymorphisms in metabolizing enzymes : some implications for colon cancer etiology, prevention, and genetic testing /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/10923.

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36

Kopsida, Maria. "Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies." Thesis, Robert Gordon University, 2018. http://hdl.handle.net/10059/3120.

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Breast cancer is the most commonly occurring cancer in women, with incidence rates approaching 1.38 million cases per year worldwide. Over the last few decades, there have been numerous attempts to develop, synthesise and advance into the clinic novel and selective breast cancer therapies. Research work has shown that bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) exerts potent in vitro anti-cancer activities and strong DNA binding properties. The aim of this thesis was to synthetise novel bisnaphthalimidopropyl derivatives (BNIPs) and investigate their subsequent modes of actio

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37

Silvestrov, Pavel. "Computational Investigation of DNA Repair Enzymes: Determination and Characterization of Cancer Biomarkers and Structural Features." Thesis, University of North Texas, 2018. https://digital.library.unt.edu/ark:/67531/metadc1157566/.

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Genomic integrity is important for living cells' correct functioning and propagation. Deoxyribonucleic acid as a molecule is a subject to chemical reactions with agents that can come from environment as well as from internal metabolism processes. These reactions can induce damage to DNA and thus compromise the genetic information, and result in disease and death of an organism. To mitigate the damage to DNA, cells have evolved to have multiple DNA repair pathways. Presented here is a computational study of DNA repair genes. The structure of the Homo sapiens direct DNA repair gene ALKBH1 is p

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38

Day, Martin Alan. "Structural comparisons of the E. coli prodrug-activating nitroreductase enzymes, NfsA and NfsB." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4346/.

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The major and minor nitroreductase enzymes of Escherichia coli, NfsA and NfsB, have both been identified as potential prodrug activating enzymes in Gene-Directed Enzyme Prodrug Therapy (GDEPT) of cancer with 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954). NfsB mutants have been selected for their ability to sensitize cells to successively lower concentrations of CB1954. In this study the crystal structures of most improved double (T41L/N71S) and triple (T41Q/N71S/F124T) mutants have been determined using X-ray crystallography. The structures help explain the improvements seen with the mutants

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39

Manzetti, Sergio. "Studies of enzymes from two protease families: Tissue Kallikreins, ADAMs and MMPs." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16088/.

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The human kallikrein family is a family of proteolytic enzymes, classified as serine proteases, that derive from chromosome 19, locus 13.3-13.4. These enzymes are widespread in pathophysiological processes such as cancer and neurodegenerative diseases; hence studies of catalytic sites and inhibitors are important in relation to the longer term of design of therapeutic drugs. One member of the family, human kallikrein 4 (hK4) which is thought to carry out crucial functions in the prostate, was expressed in this study as a secreted protein in a baculovirus expression system, bearing a His-tag an

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40

Linassier, Claude. "Signalisation cellulaire par les enzymes de la famille des phosphatidylinositol 3-kinases : caractérisation d'un enzyme de classe III et recherche d'une application en cancérogenèse." Paris 11, 1998. http://www.theses.fr/1998PA11T062.

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Les phosphatidylinositol 3-kinases (Pl 3-kinases) sont des enzymes capables d'assurer la transduction du signal par phosphorylation en position 3 de l'anneau inositol de la molécule de phosphatidylinositol. Selon la spécificité du substrat (Ptdlns, Ptdlns(4)P, Ptdlns(4,5)P2) et la structure de l'enzyme, on distingue trois grandes classes de PI 3-kinases. Le métabolite essentiel des PI 3-kinases de classe 1 est le Ptdlns(3,4,5)P3. Ces enzymes sont notamment impliqués dans la régulation de la prolifération, de la survie cellulaire et du cytosquelette. Caractérisés par un domaine C2 et par une af

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41

Marahatta, Sujan Babu Songsak Petmitr. "Polymorphism of glutathione S-transferase omega (GSTO) gene and risk of cancer among thai tients /." Abstract, 2005. http://mulinet3.li.mahidol.ac.th/thesis/2548/cd376/4637965.pdf.

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42

Gagné, Andréanne, and Andréanne Gagné. "Expression de la protéase tissulaire HtrA1 et le pronostic des femmes atteintes de cancer épithélial de l'ovaire." Master's thesis, Université Laval, 2015. http://hdl.handle.net/20.500.11794/27482.

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Introduction : La protéase High Temperature Requirement Factor A1 (HtrA1) pourrait être associée au pronostic du cancer de l’ovaire (CO). Objectif : Évaluer l’effet de l’expression de HtrA1 dans des tissus tumoraux sur le pronostic des femmes avec un CO séreux. Méthodes : Une étude de cohorte a été menée chez 122 femmes ayant un CO séreux traitées au CHU de Québec entre 1993-2006. Par immunohistochimie, l’expression de HtrA1 a été mesurée de façon visuelle et informatisée (% noyaux positifs). Des risques relatifs (HR) de progression et de décès ont été estimés avec le modèle de Cox multivarié.

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43

Baker, Shelley Louise. "Use of a direct, positive selection strategy to generate improved prodrug-activating enzymes for cancer gene therapy." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1443/.

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E. coli NfsB nitroreductase (NTR) is currently being studied in combination with the prodrug CB1954, as a gene directed enzyme prodrug therapy. NTR reduces CB1954 at either the 2- or 4-nitro groups to produce highly cytotoxic hydroxylamine derivatives, using either NADH or NADPH as cofactor. Initial clinical trials suggest activity, with reduction in PSA and apparent delayed progression in some patients. This thesis is concerned with engineering the NTR enzyme to improve the efficiency of CB1954 activation, since this would be expected to improve the potential clinical efficacy. Site directed

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44

Lagorce, Pages Christine. "Le cancer sur endobrachyoesophage : étude de la molécule d'adhérence CD44 et des enzymes du métabolisme des eicosanoïdes." Paris 7, 2004. http://www.theses.fr/2004PA077107.

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45

Blanc-Bisson, Christèle. "Contribution à l'étude des métalloprotéases matricielles des myofibroblastes dans la fibrose et dans le cancer." Bordeaux 2, 2002. http://www.theses.fr/2002BOR28946.

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Le remodelage de la matrice extracellulaire s'effectue lors de différents processus pathologiques. La matrice extracellulaire subit des modifications qualitatives et quantitatives résultant d'un excès de synthèse des composants matriciels et/ou d'une anomalie de l'expression ou de l'activité des enzymes de dégradation. Les cellules majoritairement responsables de la synthèse de la matrice extracellulaire et des protéases matricielles sont des myofibroblastes. Nous avons montré que la cyclosporine, responsable de fibrose rénale chez l'homme, provoque une dégradation de la MT1-MMP dans des cultu

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46

Asteriou, Trias. "Cinétique de la réaction d'hydrolyse du hyaluronane catalysée par la hyaluronidase testiculaire bovine : Transposition à une hyaluronidase extraite de tumeurs cancéreuses humaines." Rouen, 2002. http://www.theses.fr/2002ROUES005.

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Le hyaluronane (HA) est un polysaccharide anionique linéaire constitué de motifs disaccharidiques (N-acétyl-D-glucosamine-b(1,3)-acide-D-glucuronique) liés en b(1,4). In vivo, son catabolisme est assuré par une famille d'enzymes, les hyaluronidases (HAase). Les HAase de type testiculaire hydrolysent les liens b(1,4). La réaction d'hydrolyse du HA catalysée par la HAase testiculaire et les paramètres qui la régulent n'ont été que peu étudiés. Par ailleurs, cette réaction semble impliquée dans le développement tumoral. Le présent manuscrit constitue une étude approfondie du mode de fonctionnemen

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47

Perkins, Denise Mary. "Isolation of and interaction of nutrients with the linoleoyl-coa desaturase complex." Thesis, Rhodes University, 1990. http://hdl.handle.net/10962/d1018264.

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The termina1 enzyme in the linoleoyl-CoA desaturase enzyme complex, delta-6-desaturase was implied in the control of cell proliferation in cancer cells. One of the aims of this study was to isolate the terminal enzyme. It was decided that in order to isolate this enzyme it was first necessary to isolate the entire complex and then to enzymatically solubilise the first two components of the complex i e cytochrome b5 reductase and cytochrome b5 from the complex resulting in a pure delta-6-desaturase . The first two components were isolated and purified using simplified and easily reproducible me

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48

Hintsala, H. R. (Hanna-Riikka). "Oxidative stress and cell adhesion in skin cancer." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526212692.

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Abstract Skin is the largest organ in our body protecting us from ultraviolet radiation and xenobiotics. UV-radiation is a common cause of squamocellular carcinoma and melanoma of the skin that cause morbidity and mortality world wide. Reactive oxygen species are constantly formed by, for example, cellular respiration and UV-radiation, and they can readily react with virtually any macromolecule within cell structures causing damage to DNA, proteins and lipids. Oxidative stress (OS) is a homeostatic process that is dysregulated in cancer cells to their benefit. Nuclear factor erythroid-2-relate

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49

Ramos, Delgado Carmen Fernanda. "Exploring PI3K signalling dynamics in pancreatic cancer." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30152.

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Les PI3K sont des enzymes qui phosphorylent le groupe hydroxyl en position 3 des phosphatidylinositols comme le PIP2 ou le PI. Ces lipides sont impliqués dans de nombreux processus cellulaires tels que la croissance, la prolifération, la motilité, l'autophagie et le trafic cellulaire. Chez les mammifères, il y a 8 isoformes de PI3K et elles sont regroupées en trois classes (I, II et III) en fonction de leur structure et spécificité du substrat. Les PI3K de classe I sont les mieux caractérisées et impliquées dans le cancer. Les rôles oncogéniques des PI3K de classe II et III restent méconnus. L

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50

Abdullah, Ammara. "Inhibitors of cytochrome P450 enzymes CYP17 and 17β-HSD3 : their role in the treatment of hormone-dependent prostate and breast cancer". Thesis, Kingston University, 2012. http://eprints.kingston.ac.uk/25093/.

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Androgens play an important part in the initiation and progression of hormone-dependent prostate and breast cancer. These types of cancers can be treated by androgen ablation therapy. However, androgen ablation is associated with short (2-3 years) remission of the disease. Therefore therapies that inhibit the systemic biosynthesis of androgens, by targeting the P450 enzymes (CYP17 and 17-[beta]HSD type 3) which catalyse androgen biosynthesis, may represent a rational approach in the treatment of androgen-dependent cancer. Inhibitors of the enzyme CYP17: ketoconazole and liarozole, have been sh

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