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Journal articles on the topic 'Cancer epigenetics'

Author: Grafiati

Published: 8 March 2025

Last updated: 26 July 2025

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1

Youness, Eman. "Overview on Epigenetics and Cancer." Clinical Medical Reviews and Reports 2, no. 3 (2020): 01–06. http://dx.doi.org/10.31579/2690-8794/015.

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Epigenetics is considered as the science of hereditary phenotype which does not encompass amendment in the DNA. This occurs through chemical processes that modify the phenotype, without altering the genotype. A large number of studies showed that metabolic diseases are highly associated with epigenetic alterations suggesting that epigenetic factors may play a central role in cancer. Recent advancements in the rapidly evolving field of cancer epigenetics have shown extensive reprogramming of every component of the epigenetic machinery in cancer including DNA methylation, histone modifications,

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2

Li, Jiaqiu, Hongchuan Jin, and Xian Wang. "Epigenetic Biomarkers: Potential Applications in Gastrointestinal Cancers." ISRN Gastroenterology 2014 (March 6, 2014): 1–10. http://dx.doi.org/10.1155/2014/464015.

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Genetics and epigenetics coregulate the cancer initiation and progression. Epigenetic mechanisms include DNA methylation, histone modification, chromatin remodeling, and noncoding RNAs. Aberrant epigenetic modifications play a fundamental role in the formation of gastrointestinal cancers. Advances in epigenetics offer a better understanding of the carcinogenesis and provide new insights into the discovery of biomarkers for diagnosis, and prognosis prediction of human cancers. This review aims to overview the epigenetic aberrance and the clinical applications as biomarkers in gastrointestinal c

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Pathak, Ayush, Sarthak Tomar, and Sujata Pathak. "Epigenetics and Cancer: A Comprehensive Review." Asian Pacific Journal of Cancer Biology 8, no. 1 (2023): 75–89. http://dx.doi.org/10.31557/apjcb.2023.8.1.75-89.

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Cancer is a disease with extraordinary clinical significance, with much of medical research being devoted to it. Innumerable factors are relevant in fully understanding cancer but the epigenetic aspect stands out. Epigenetics is the study of changes, often germ-line, to the genome affecting the gene expression by silencing certain genes and modifying the gene expression. The three primary mechanisms for epigenetic changes are DNA methylation, histone modification and non-coding RNA (ncRNA) associated gene silencing. While epigenetics is a pivotal mechanism for the regular maintenance of a myri

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Chou, PoChung Jordan, Rebecca Mary Peter, Ahmad Shannar, et al. "Epigenetics of Dietary Phytochemicals in Cancer Prevention." Cancer Journal 30, no. 5 (2024): 320–28. http://dx.doi.org/10.1097/ppo.0000000000000742.

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Abstract Cancer development takes 10 to 50 years, and epigenetics plays an important role. Recent evidence suggests that ~80% of human cancers are linked to environmental factors impinging upon genetics/epigenetics. Because advanced metastasized cancers are resistant to radiation/chemotherapeutic drugs, cancer prevention by relatively nontoxic “epigenetic modifiers” will be logical. Many dietary phytochemicals possess powerful antioxidant and anti-inflammatory properties that are hallmarks of cancer prevention. Dietary phytochemicals can regulate gene expression of the cellular genome via epig

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Rahman, Md, HM Jamil, Naznin Akhtar, et al. "Cancer epigenetics and epigenetical therapy." Journal of Experimental and Integrative Medicine 6, no. 3 (2016): 143. http://dx.doi.org/10.5455/jeim.270616.rw.016.

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Yadav, Rinki, Ashish Srivastava, Suresh Chandra, and A.K. Rai. "ROLE OF EPIGENETIC MECHANISMS IN VARIOUS CANCER THERAPIES." Pharmaceutical and Biological Evaluations 3, no. 2 (2016): 178–84. https://doi.org/10.5281/zenodo.51060.

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Epigenetics play a role not just in the normal functioning of the cell and its development, but also in diseases like neurological diseases and cancer. Epigenetic therapies can help to resolve non-identical problems of these pathophysiological conditions. Cancer is a complex disease with both genetic and epigenetic origins. The importance of epigenetics in cancer has been identified, and the field has emerged rapidly in recent years. Epigenetic and genetic alterations contribute to the initiation and progression of cancer. Epigenetic modifications introduced genetic changes, and usually occur

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Hatzimichael, Eleftheria, and Tim Crook. "Cancer Epigenetics: New Therapies and New Challenges." Journal of Drug Delivery 2013 (February 26, 2013): 1–9. http://dx.doi.org/10.1155/2013/529312.

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Cancer is nowadays considered to be both a genetic and an epigenetic disease. The most well studied epigenetic modification in humans is DNA methylation; however it becomes increasingly acknowledged that DNA methylation does not work alone, but rather is linked to other modifications, such as histone modifications. Epigenetic abnormalities are reversible and as a result novel therapies that work by reversing epigenetic effects are being increasingly explored. The biggest clinical impact of epigenetic modifying agents in neoplastic disorders thus far has been in haematological malignancies, and

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8

Maio, Michele. "Introduction: Cancer Epigenetics and Epigenetic Treatment of Cancer." Seminars in Oncology 32, no. 5 (2005): 435–36. http://dx.doi.org/10.1053/j.seminoncol.2005.08.001.

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9

Kanwal, Rajnee, and Sanjay Gupta. "Epigenetics and cancer." Journal of Applied Physiology 109, no. 2 (2010): 598–605. http://dx.doi.org/10.1152/japplphysiol.00066.2010.

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Epigenetic modifications are central to many human diseases, including cancer. Traditionally, cancer has been viewed as a genetic disease, and it is now becoming apparent that the onset of cancer is preceded by epigenetic abnormalities. Investigators in the rapidly expanding field of epigenetics have documented extensive genomic reprogramming in cancer cells, including methylation of DNA, chemical modification of the histone proteins, and RNA-dependent regulation. Recognizing that carcinogenesis involves both genetic and epigenetic alterations has led to a better understanding of the molecular

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10

van Engeland, Manon, Sarah Derks, Kim M. Smits, Gerrit A. Meijer, and James G. Herman. "Colorectal Cancer Epigenetics: Complex Simplicity." Journal of Clinical Oncology 29, no. 10 (2011): 1382–91. http://dx.doi.org/10.1200/jco.2010.28.2319.

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Colorectal cancer (CRC) has predominantly been considered a genetic disease, characterized by sequential accumulation of genetic alterations. Growing evidence indicates that epigenetic alterations add an additional layer of complexity to the pathogenesis of CRC, and characterize a subgroup of colorectal cancers with a distinct etiology and prognosis. Epigenetic dysregulation in colorectal cancer is organized at multiple levels, involving DNA methylation, histone modifications, nucleosomal occupancy and remodeling, chromatin looping, and noncoding RNAs. Interactions between these processes and

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Mir, Snober Shabnam, Uzma Afaq, Adria Hasan, Suroor Fatima Rizvi, and Sana Parveen. "Novel Insights into Epigenetic Control of Autophagy in Cancer." OBM Genetics 06, no. 04 (2022): 1–45. http://dx.doi.org/10.21926/obm.genet.2204170.

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The autophagy mechanism recycles the damaged and long-standing macromolecular substrates and thus maintains cellular homeostatic and proteostatic conditions. Autophagy can be an unavoidable target in cancer therapy because its deregulation leads to cancer formation and progression. Cancer can be controlled by regulating autophagy at different genetic, epigenetic, and post-translational levels. Epigenetics refers to the heritable phenotypic changes that affect gene activity without changing the sequence. Modern biology employs epigenetic alterations as molecular tools to detect and treat a wide

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Katu, Amina H. "The Role of Epigenetics in Disease Development." RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY 3, no. 2 (2024): 41–44. http://dx.doi.org/10.59298/rijpp/2024/3234144.

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Epigenetics, the study of heritable changes in gene expression without alterations to the DNA sequence, plays a critical role in the development of various diseases. These epigenetic mechanisms, which include DNA methylation, histone modifications, and non-coding RNA-mediated gene silencing, regulate essential cellular processes such as differentiation, development, and tissue-specific gene expression. Environmental factors and lifestyle choices influence these epigenetic changes, often leading to disease by modifying transcriptional profiles. This paper discusses the role of epigenetics in th

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13

Zhang, Xiaolin, Zhen Dong, and Hongjuan Cui. "Interplay between Epigenetics and Cellular Metabolism in Colorectal Cancer." Biomolecules 11, no. 10 (2021): 1406. http://dx.doi.org/10.3390/biom11101406.

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Cellular metabolism alterations have been recognized as one of the most predominant hallmarks of colorectal cancers (CRCs). It is precisely regulated by many oncogenic signaling pathways in all kinds of regulatory levels, including transcriptional, post-transcriptional, translational and post-translational levels. Among these regulatory factors, epigenetics play an essential role in the modulation of cellular metabolism. On the one hand, epigenetics can regulate cellular metabolism via directly controlling the transcription of genes encoding metabolic enzymes of transporters. On the other hand

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Liu, Yu’e, Chao Chen, Xinye Wang, et al. "An Epigenetic Role of Mitochondria in Cancer." Cells 11, no. 16 (2022): 2518. http://dx.doi.org/10.3390/cells11162518.

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Mitochondria are not only the main energy supplier but are also the cell metabolic center regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These metabolites include acetyl-CoA, α-ketoglutarate (α-KG), S-adenosyl methionine (SAM), NAD+, and O-linked beta-N-acetylglucosamine (O-GlcNAc), which are the main substrates for DNA methylation and histone post-translation modifications, essential for gene transcriptional regulation and cell fate determination. Tumorigenesis is attributed to many factors, including gene mutations and tumor microenvironment. Mitochond

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15

Taby, Rodolphe, and Jean-Pierre J. Issa. "Cancer Epigenetics." CA: A Cancer Journal for Clinicians 60, no. 6 (2010): 376–92. http://dx.doi.org/10.3322/caac.20085.

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16

Momparler, Richard L. "Cancer epigenetics." Oncogene 22, no. 42 (2003): 6479–83. http://dx.doi.org/10.1038/sj.onc.1206774.

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Laird, Peter W. "Cancer epigenetics." Human Molecular Genetics 14, suppl_1 (2005): R65—R76. http://dx.doi.org/10.1093/hmg/ddi113.

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18

Ahmed, Hafiz Ghulam Muhu-Din, Aziz Ullah, Abdul Malik, and Babar Islam. "Review; Role of epigenetics in cancer." World Journal of Biology and Biotechnology 5, no. 2 (2020): 51. http://dx.doi.org/10.33865/wjb.005.02.0304.

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The epigenetic alterations are central to numerous human diseases, counting cancer. Typically, cancer has been seen as a hereditary infection, and it is presently getting to be clear that the onset of cancer is gone before by epigenetic anomalies. Examiners within the quickly growing field of epigenetics have recorded broad genomic reconstructing in cancer cells, counting methylation of deoxyribonucleic acid (DNA), chemical alteration of the histone proteins, and RNA-dependent control. Recognizing that carcinogenesis includes both hereditary and epigenetic alterations have driven to distant be

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19

Sachdev, Sanpreet Singh, and Sonali Kohli. "Epigenetics: Unraveling the molecular threads of aging and dermal cancer." IP Indian Journal of Clinical and Experimental Dermatology 10, no. 1 (2024): 103–6. http://dx.doi.org/10.18231/j.ijced.2024.020.

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Epigenetics, the study of heritable alterations in gene expression without changes to the DNA sequence, plays a pivotal role in understanding the complex processes of aging and cancer. This manuscript delves into the intricate world of epigenetics, exploring how it influences the pathophysiology of aging and aging-related diseases, with a particular focus on cancer. We discuss the mechanisms of epigenetic regulation, the interplay between genetic and epigenetic alterations, and the potential implications for diagnosis and drug discovery.

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20

Sengupta, Deepanwita. "Epigenetic Drugs - The Future of Cancer Therapy." Annals of Experimental and Molecular Biology 2, no. 1 (2019): 1–2. http://dx.doi.org/10.23880/aemb-16000106.

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Epigenetics refers to any alteration in gene expression that occurs without affecting the underlying DNA sequence. Epigenetic mechanisms regulate the accessibility of chromatin to transcription factors by promoting nucleosomal rearrangement via the addition or removal of acetyl or/and methyl groups to histones. Nucleosomes are basic units of chromosomes comprising of 147 base pairs of DNA wrapped around an octamer of histone proteins

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21

Bassal, Mahmoud Adel. "The Interplay between Dysregulated Metabolism and Epigenetics in Cancer." Biomolecules 13, no. 6 (2023): 944. http://dx.doi.org/10.3390/biom13060944.

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Cellular metabolism (or energetics) and epigenetics are tightly coupled cellular processes. It is arguable that of all the described cancer hallmarks, dysregulated cellular energetics and epigenetics are the most tightly coregulated. Cellular metabolic states regulate and drive epigenetic changes while also being capable of influencing, if not driving, epigenetic reprogramming. Conversely, epigenetic changes can drive altered and compensatory metabolic states. Cancer cells meticulously modify and control each of these two linked cellular processes in order to maintain their tumorigenic potenti

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22

Pardo, Juan C., Vicenç Ruiz de Porras, Joan Gil, Albert Font, Manel Puig-Domingo, and Mireia Jordà. "Lipid Metabolism and Epigenetics Crosstalk in Prostate Cancer." Nutrients 14, no. 4 (2022): 851. http://dx.doi.org/10.3390/nu14040851.

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Prostate cancer (PCa) is the most commonly diagnosed malignant neoplasm in men in the Western world. Localized low-risk PCa has an excellent prognosis thanks to effective local treatments; however, despite the incorporation of new therapeutic strategies, metastatic PCa remains incurable mainly due to disease heterogeneity and the development of resistance to therapy. The mechanisms underlying PCa progression and therapy resistance are multiple and include metabolic reprogramming, especially in relation to lipid metabolism, as well as epigenetic remodelling, both of which enable cancer cells to

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23

Lee, Dong Yeul, Talha Salahuddin, and Jabed Iqbal. "Lysine-Specific Demethylase 1 (LSD1)-Mediated Epigenetic Modification of Immunogenicity and Immunomodulatory Effects in Breast Cancers." Current Oncology 30, no. 2 (2023): 2127–43. http://dx.doi.org/10.3390/curroncol30020164.

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Tumor evolution to evade immune surveillance is a hallmark of carcinogenesis, and the modulation of tumor immunogenicity has been a challenge to present therapeutic responses in immunotherapies alone for numerous cancers. By altering the cell phenotype and reshaping the tumor microenvironment, epigenetic modifications enable tumor cells to overcome immune surveillance as a mechanism of cancer progression and immunotherapy resistance. Demethylase enzymatic activity of lysine-specific demethylase 1 (LSD1), a histone demethylase first identified in 2004, plays a pivotal role in the vast cellular

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24

MacLennan, Signe A., and Marco A. Marra. "Oncogenic Viruses and the Epigenome: How Viruses Hijack Epigenetic Mechanisms to Drive Cancer." International Journal of Molecular Sciences 24, no. 11 (2023): 9543. http://dx.doi.org/10.3390/ijms24119543.

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Globally, viral infections substantially contribute to cancer development. Oncogenic viruses are taxonomically heterogeneous and drive cancers using diverse strategies, including epigenomic dysregulation. Here, we discuss how oncogenic viruses disrupt epigenetic homeostasis to drive cancer and focus on how virally mediated dysregulation of host and viral epigenomes impacts the hallmarks of cancer. To illustrate the relationship between epigenetics and viral life cycles, we describe how epigenetic changes facilitate the human papillomavirus (HPV) life cycle and how changes to this process can s

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Albany, Costantine, Ajjai S. Alva, Ana M. Aparicio, et al. "Epigenetics in Prostate Cancer." Prostate Cancer 2011 (2011): 1–12. http://dx.doi.org/10.1155/2011/580318.

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Prostate cancer (PC) is the most commonly diagnosed nonskin malignancy and the second most common cause of cancer death among men in the United States. Epigenetics is the study of heritable changes in gene expression caused by mechanisms other than changes in the underlying DNA sequences. Two common epigenetic mechanisms, DNA methylation and histone modification, have demonstrated critical roles in prostate cancer growth and metastasis. DNA hypermethylation of cytosine-guanine (CpG) rich sequence islands within gene promoter regions is widespread during neoplastic transformation of prostate ce

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Li, Yinglu, Zhiming Li, and Wei-Guo Zhu. "Molecular Mechanisms of Epigenetic Regulators as Activatable Targets in Cancer Theranostics." Current Medicinal Chemistry 26, no. 8 (2019): 1328–50. http://dx.doi.org/10.2174/0929867324666170921101947.

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Epigenetics is defined as somatically inheritable changes that are not accompanied by alterations in DNA sequence. Epigenetics encompasses DNA methylation, covalent histone modifications, non-coding RNA as well as nucleosome remodeling. Notably, abnormal epigenetic changes play a critical role in cancer development including malignant transformation, metastasis, prognosis, drug resistance and tumor recurrence, which can provide effective targets for cancer prognosis, diagnosis and therapy. Understanding these changes provide effective means for cancer diagnosis and druggable targets for better

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Hoque, Majedul, Kazi Emon, Kazi Emon Md Aktaruzzaman, Md Nahid Hasan, Arafath Jubayer, and Mohammad Sabbir Hossain. "A Mini Review on Cancer Epigenetics." Middle East Research Journal of Medical Sciences 3, no. 02 (2023): 28–38. http://dx.doi.org/10.36348/merjms.2023.v03i02.002.

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Cancer epigenetics is the study of epigenetic changes to cancer cells' DNA that don't involve a change in the nucleotide sequence but instead affect how the genetic code is expressed. The complicated disease of cancer is brought on by genetic and epigenetic changes in the regulation of cell division. Our knowledge of the molecular etiology of cancer has substantially advanced and also the discoveries in the fields of cancer genomics and epigenomics, which have improved our comprehension of the development and evolution of tumorigenic processes. The interaction between genetic and epigenetic mu

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Tarashi, Samira, Sara Ahmadi Badi, Arfa Moshiri, et al. "The inter-talk between Mycobacterium tuberculosis and the epigenetic mechanisms." Epigenomics 12, no. 5 (2020): 455–69. http://dx.doi.org/10.2217/epi-2019-0187.

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Epigenetics regulate gene function without any alteration in the DNA sequence. The epigenetics represent one of the most important regulators in different cellular processes and have initially been developed in microorganisms as a protective strategy. The evaluation of the epigenetic mechanisms is also important in achieving an efficient control strategy in tuberculosis (TB). TB is one of the most significant epidemiological concerns in human history. Despite several in vivo and in vitro studies that have evaluated different epigenetic modifications in TB, many aspects of the association betwe

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Vinokurova, Svetlana. "Epigenetics of Virus-Induced Tumors: Perspectives for Therapeutic Targeting." Current Pharmaceutical Design 23, no. 32 (2017): 4842–61. http://dx.doi.org/10.2174/1381612823666170822100627.

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About 15–20% of human cancers worldwide have viral etiology. Seven human DNA and RNA viruses are accepted to be oncogenic viruses or oncoviruses and contribute to the development of various cancer types. Human oncoviruses have developed multiple molecular mechanisms to interfere with specific cellular pathways to promote viral replication and viral life cycle maintenance in the host. Despite the diversity of oncogenic viruses, they use similar strategies for cancer development. Viral oncoproteins and viral non-coding RNAs are the key factors that can affect multiple cellular processes on both

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Liu, Na, Rongtong Zhao, Yue Ma, et al. "The Development of Epigenetics and Related Inhibitors for Targeted Drug Design in Cancer Therapy." Current Topics in Medicinal Chemistry 18, no. 28 (2019): 2380–94. http://dx.doi.org/10.2174/1568026618666181115092623.

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Epigenetics process is the heritable change in gene function that does not involve changes in the DNA sequence. Until now, several types of epigenetic mechanisms have been characterized, including DNA methylation, histone modification (acetylation, methylation, etc.), nucleosome remodeling, and noncoding RNAs. With the biological investigations of these modifiers, some of them are identified as promoters in the process of various diseases, such as cancer, cardiovascular disease and virus infection. Epigenetic changes may serve as potential “first hits” for tumorigenesis. Hence, targeting epige

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Roalsø, Marcus T. T., Øyvind H. Hald, Marina Alexeeva, and Kjetil Søreide. "Emerging Role of Epigenetic Alterations as Biomarkers and Novel Targets for Treatments in Pancreatic Ductal Adenocarcinoma." Cancers 14, no. 3 (2022): 546. http://dx.doi.org/10.3390/cancers14030546.

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Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with limited treatment options. Emerging evidence shows that epigenetic alterations are present in PDAC. The changes are potentially reversible and therefore promising therapeutic targets. Epigenetic aberrations also influence the tumor microenvironment with the potential to modulate and possibly enhance immune-based treatments. Epigenetic marks can also serve as diagnostic screening tools, as epigenetic changes occur at early stages of the disease. Further, epigenetics can be used in prognostication. The field is evolving, and this r

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Aydin, Cansu, and Rasime Kalkan. "Cancer Treatment: An Epigenetic View." Global Medical Genetics 07, no. 01 (2020): 003–7. http://dx.doi.org/10.1055/s-0040-1713610.

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AbstractCancer can be identified as an uncontrolled growth and reproduction of cell. Accumulation of genetic aberrations (mutations of oncogenes and tumor-suppressor genes and epigenetic modifications) is one of the characteristics of cancer cell. Increasing number of studies highlighted importance of the epigenetic alterations in cancer treatment and prognosis. Now, cancer epigenetics have a huge importance for developing novel biomarkers and therapeutic target for cancer. In this review, we will provide a summary of the major epigenetic changes involved in cancer and preclinical results of e

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Kandy, Rakhee Rathnam Kalari, Madan Kumar Arumugam, Mukesh Pratap Yadav, Bibhuti Bhusan Mishra, and Jyotika Sharma. "ARID4B: An Orchestrator from Stem Cell Fate to Carcinogenesis." Cells 14, no. 12 (2025): 872. https://doi.org/10.3390/cells14120872.

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All biological processes, from embryonic development to cancer, are tightly controlled by the interactions between genetics and epigenetics. An array of epigenetic modifications, such as DNA methylation, histone/chromatin modifications, and noncoding RNA-mediated targeting, are essential to regulate the heritable changes that occur during multiple cellular processes. A failure in proper regulation results in inappropriate gene expression that ultimately leads to pathological states. Groundbreaking advances in genomics and transcriptomics have revealed the potential involvement of epigenetics i

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34

Esteller, Manel. "Epigenetics in Cancer." New England Journal of Medicine 358, no. 11 (2008): 1148–59. http://dx.doi.org/10.1056/nejmra072067.

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Ahmad, Aamir. "Editorial: Cancer Epigenetics." Current Cancer Drug Targets 18, no. 1 (2017): 3–4. http://dx.doi.org/10.2174/156800961801171208144307.

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Lund, A. H. "Epigenetics and cancer." Genes & Development 18, no. 19 (2004): 2315–35. http://dx.doi.org/10.1101/gad.1232504.

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Verma, Mukesh, Padma Maruvada, and Sudhir Srivastava. "Epigenetics and Cancer." Critical Reviews in Clinical Laboratory Sciences 41, no. 5-6 (2004): 585–607. http://dx.doi.org/10.1080/10408360490516922.

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Esteller, M. "Cancer pharmaco-epigenetics." Clinica Chimica Acta 493 (June 2019): S761—S762. http://dx.doi.org/10.1016/j.cca.2019.03.1353.

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Bae, Jae‐Bum, and Young‐Joon Kim. "Cancer and epigenetics." Animal Cells and Systems 12, no. 3 (2008): 117–25. http://dx.doi.org/10.1080/19768354.2008.9647164.

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Sharma, S., T. K. Kelly, and P. A. Jones. "Epigenetics in cancer." Carcinogenesis 31, no. 1 (2009): 27–36. http://dx.doi.org/10.1093/carcin/bgp220.

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Słowikowski, Bartosz, Wojciech Owecki, Jan Jeske, et al. "Epigenetics and the neurodegenerative process." Epigenomics 16, no. 7 (2024): 473–91. http://dx.doi.org/10.2217/epi-2023-0416.

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Neurological diseases are multifactorial, genetic and environmental. Environmental factors such as diet, physical activity and emotional state are epigenetic factors. Environmental markers are responsible for epigenetic modifications. The effect of epigenetic changes is increased inflammation of the nervous system and neuronal damage. In recent years, it has been shown that epigenetic changes may cause an increased risk of neurological disorders but, currently, the relationship between epigenetic modifications and neurodegeneration remains unclear. This review summarizes current knowledge abou

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Bhattacharjee, Dipanjan, Smita Shenoy, and Kurady Laxminarayana Bairy. "DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics." Scientifica 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/6072357.

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Epigenetics deals with the interactions between genes and the immediate cellular environment. These interactions go a long way in shaping up each and every person’s individuality. Further, reversibility of epigenetic interactions may offer a dynamic control over the expression of various critical genes. Thus, tweaking the epigenetic machinery may help cause or cure diseases, especially cancer. Therefore, cancer epigenetics, especially at a molecular level, needs to be scrutinised closely, as it could potentially serve as the future pharmaceutical goldmine against neoplastic diseases. However,

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Papakonstantinou, Eleni, Konstantina Dragoumani, George P. Chrousos, and Dimitrios Vlachakis. "Exosomal Epigenetics." EMBnet.journal 29 (May 22, 2024): e1049. http://dx.doi.org/10.14806/ej.29.0.1049.

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Epigenetics is the study of heritable changes in gene expression that occur without changes to the underlying DNA sequence. Epigenetic modifications can include DNA methylation, histone modifications, and non-coding RNAs, among others. These modifications can influence the expression of genes by altering the way DNA is packaged and accessed by transcriptional machinery, thereby affecting cellular function and behavior. Epigenetic modifications can be influenced by a variety of factors, including environmental exposures, lifestyle factors, and aging, whilst abnormal epigenetic modifications hav

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Tan, Wan Ying, Snigdha Nagabhyrava, Olivia Ang-Olson, et al. "Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology." Current Issues in Molecular Biology 46, no. 7 (2024): 6533–65. http://dx.doi.org/10.3390/cimb46070390.

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Technological advancements in cell-free DNA (cfDNA) liquid biopsy have triggered exponential growth in numerous clinical applications. While cfDNA-based liquid biopsy has made significant strides in personalizing cancer treatment, the exploration and translation of epigenetics in liquid biopsy to clinical practice is still nascent. This comprehensive review seeks to provide a broad yet in-depth narrative of the present status of epigenetics in cfDNA liquid biopsy and its associated challenges. It highlights the potential of epigenetics in cfDNA liquid biopsy technologies with the hopes of enha

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Pandkar, Madhura R., and Sanjeev Shukla. "Epigenetics and alternative splicing in cancer: old enemies, new perspectives." Biochemical Journal 481, no. 21 (2024): 1497–518. http://dx.doi.org/10.1042/bcj20240221.

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In recent years, significant strides in both conceptual understanding and technological capabilities have bolstered our comprehension of the factors underpinning cancer initiation and progression. While substantial insights have unraveled the molecular mechanisms driving carcinogenesis, there has been an overshadowing of the critical contribution made by epigenetic pathways, which works in concert with genetics. Mounting evidence demonstrates cancer as a complex interplay between genetics and epigenetics. Notably, epigenetic elements play a pivotal role in governing alternative pre-mRNA splici

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LaBarge, Mark A., E. Lorena Mora-Blanco, Susan Samson, and Masaru Miyano. "Breast Cancer beyond the Age of Mutation." Gerontology 62, no. 4 (2015): 434–42. http://dx.doi.org/10.1159/000441030.

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Age is the greatest risk factor for breast cancer, but the reasons underlying this association are unclear. While there is undeniably a genetic component to all cancers, the accumulation of mutations with age is insufficient to explain the age-dependent increase in breast cancer incidence. In this viewpoint, we propose a multilevel framework to better understand the respective roles played by somatic mutation, microenvironment, and epigenetics making women more susceptible to breast cancer with age. The process of aging is associated with gradual breast tissue changes that not only corrupt the

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Agarwal, Avarna, and Prasanta Padhan. "Understanding epigenetics in health and human diseases – An overview." Journal of Integrative Medicine and Research 2, no. 4 (2024): 215–18. http://dx.doi.org/10.4103/jimr.jimr_54_24.

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Abstract: Epigenetics, the study of heritable changes in gene expression without alterations to the DNA sequence, is crucial for the complex interplay of genetic and environmental factors influencing human health. This overview traces the historical evolution of epigenetics, from early conceptualizations by Valentin Haecker and Conrad Waddington to modern insights such as epigenetic editing. Key mechanisms such as DNA methylation, histone modifications, and noncoding RNAs are explored, highlighting their roles in various diseases including cancer, cardiovascular conditions, neurodegenerative d

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Quratulain, Babar, Saeed Ayesha, A. Tabish Tanveer, Pricl Sabrina, Townley Helen, and Thorat Nanasaheb. "Novel epigenetic therapeutic strategies and targets in cancer." Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1868, no. 12 (2022): 166552. https://doi.org/10.1016/j.bbadis.2022.166552.

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The critical role of dysregulated epigenetic pathways in cancer genesis, development, and therapy has typically been established as a result of scientific and technical innovations in next generation sequencing. RNA interference, histone modification, DNA methylation and chromatin remodelling are epigenetic processes that control gene expression without causing mutations in the DNA. Although epigenetic abnormalities are thought to be a symptom of cell tumorigenesis and malignant events that impact tumor growth and drug resistance, physicians be

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Capparelli, Rosanna, and Domenico Iannelli. "Epigenetics and Helicobacter pylori." International Journal of Molecular Sciences 23, no. 3 (2022): 1759. http://dx.doi.org/10.3390/ijms23031759.

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Epigenetics regulates gene expression, cell type development during differentiation, and the cell response to environmental stimuli. To survive, bacteria need to evade the host immune response. Bacteria, including Helicobacter pylori (Hp), reach this target epigenetically, altering the chromatin of the host cells, in addition to several more approaches, such as DNA mutation and recombination. This review shows that Hp prevalently silences the genes of the human gastric mucosa by DNA methylation. Epigenetics includes different mechanisms. However, DNA methylation persists after DNA replication

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Schulz, Wolfgang A., and Karina D. Sørensen. "Epigenetics of Urological Cancers." International Journal of Molecular Sciences 20, no. 19 (2019): 4775. http://dx.doi.org/10.3390/ijms20194775.

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The major urological cancers comprise prostate adenocarcinoma, urinary bladder (or upper urinary tract) carcinoma, renal cell carcinoma, testicular cancer and penile carcinoma, in this order of incidence, each with various histological and molecular subtypes [...]

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