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Dissertations / Theses on the topic 'Cancer immunity'

Author: Grafiati
Published: 14 December 2024

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1

Zunino, Barbara. "Dialogue entre le métabolisme et l’immunité dans le traitement des cancers." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4113.

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Il est connu depuis de nombreuses années que le métabolisme des cellules cancéreuses diffère de celui des cellules saines. La Restriction Calorique (RC) est connue pour prolonger la durée de vie et pour limiter l’oncogenèse. Ainsi, il a été montré que la RC et ses mimétiques comme le 2-deoxyglucose (2DG) augmentent l’efficacité de la chimiothérapie et peuvent aussi induire une immunité anti-tumorale. J’ai pu montrer qu’en régulant le métabolisme via la restriction calorique (ou des mimétiques) nous pouvions moduler l’expression de la protéine anti-apoptotique Mcl-1. Ainsi nous avons établi in
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2

They, Laetitia. "Renforcement des effets immunomodulateurs d’un anticorps monoclonal anti-tumoral : étude des effets potentialisateurs de thérapies combinées et analyse des mécanismes impliqués." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT076/document.

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Le mélanome est la forme la plus agressive des cancers de la peau. Si sa prise en charge à des stades précoces est de bon pronostic, l’espérance de vie des patients chute dramatiquement pour les stades métastatiques. Malgré les avancées thérapeutiques spectaculaires récentes, le problème majeur réside dans la résistance aux traitements et la récidive et le défi principal est désormais de tendre vers un contrôle efficace et durable. Les anticorps monoclonaux (AcM) ont la capacité de cibler et éliminer spécifiquement la cellule tumorale tout en recrutant des cellules du système immunitaire, perm
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3

Zunino, Barbara. "Dialogue entre le métabolisme et l’immunité dans le traitement des cancers." Electronic Thesis or Diss., Nice, 2014. http://www.theses.fr/2014NICE4113.

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Il est connu depuis de nombreuses années que le métabolisme des cellules cancéreuses diffère de celui des cellules saines. La Restriction Calorique (RC) est connue pour prolonger la durée de vie et pour limiter l’oncogenèse. Ainsi, il a été montré que la RC et ses mimétiques comme le 2-deoxyglucose (2DG) augmentent l’efficacité de la chimiothérapie et peuvent aussi induire une immunité anti-tumorale. J’ai pu montrer qu’en régulant le métabolisme via la restriction calorique (ou des mimétiques) nous pouvions moduler l’expression de la protéine anti-apoptotique Mcl-1. Ainsi nous avons établi in
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4

Decque, Adrien. "Etude de la SUMOylation dans l’immunité innée et l’oncogenèse." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066312/document.

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La SUMOylation est une modification post-traductionnelle réversible permettant de diversifier les fonctions de centaines de substrats. Elle est impliquée dans des processus essentiels à la cellule et à l'organisme, tels que la réparation de l'ADN, la mitose, la transcription. A l'aide de modèles murins génétiquement modifiés déficients pour l'unique enzyme E2 de SUMOylation, UBC9, nous avons caractérisé les conséquences de la réduction de la SUMOylation sur l'immunité innée et l'oncogenèse.Nous révélons un rôle majeur de la SUMOylation dans la régulation négative du gène codant pour l'IFN- . L
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5

Meyer, Andrea Michael. "Ro52 in innate immunity, proliferation control and cancer /." Zürich : ETH, 2009. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18198.

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6

Al, Khathami Ali Gaithan. "Towards gastric cancer immunotherapy : assessment of cancer immunity and potential immune targets." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8855/.

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Gastric cancer (GC), the fourth most common malignancy worldwide, has poor prognosis and treatment innovation is needed. The aims of this project were to investigate immune targets and treatment strategies for GC. I identified new T-cell epitopes in three Epstein-Barr virus (EBV) tumor antigens, LMP1, LMP2 and BARF1, expressed in the 10% of GC cases positive for EBV. T-cell clones showed that a BARF1-specific CD4 T-cell epitope restricted by HLA-DR51, an allele common in the population, was presented by an EBV-positive epithelial cancer cell line. Analysing blood and fresh tumor from newly dia
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7

Titu, Liviu. "Specific cytotoxic lymphocyte immunity against telomerase in colorectal cancer." Thesis, University of Hull, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273656.

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8

Gajurel, Damodar. "Boosting Anti-Cancer Immunity with a Novel Chimeric Molecule." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/370742.

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High mortality, second only to cardiovascular causes, and high morbidity (physical as well as psychological) from cancer are unacceptable. Despite many years of multi-modality (conventional) treatment with surgery, radiotherapy, and chemotherapy, the status of cancer management, especially lung cancer, is still not satisfactory and alternate management strategies need to be developed. Anti-tumour immunotherapy is being explored as a potential new form of cancer therapies. Cancer vaccines, as forms of immunotherapy, have been developed and tested in clinical trials. Unfortunately, almost all of
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9

Lemay, Chantal. "Harnessing Oncolytic Virus-mediated Anti-tumour Immunity." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23318.

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Treatment of permissive tumours with the oncolytic virus (OV) VSV-Δ51 leads to a robust anti-tumour T cell response, which contributes to efficacy; however, many tumours are not permissive to in vivo treatment with VSV-Δ51. In an attempt to channel the immune stimulatory properties of VSV-Δ51 and broaden the scope of tumours that can be treated by an OV, a potent oncolytic vaccine platform was developed, consisting of tumour cells infected with VSV-Δ51. I demonstrate that prophylactic immunization with this infected cell vaccine (ICV) protected mice from subsequent tumour challenge, and expres
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10

Aloulou, Nijez. "Rôle de la leptine dans le cancer colorectal humain." Thesis, Paris Est, 2008. http://www.theses.fr/2008PEST0027.

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Par sa fréquence et sa gravité, le CCR représente un réel problème de santé publique. Avec 37000 nouveaux cas par an et 15% des décès, il constitue la 2ème cause de mortalité par cancer en France. Malgré d'importants progrès thérapeutiques durant cette dernière décennie, il rest un cancer de mauvais pronostic. Des facteurs génétiques et environnementaux ont été impliqués dans la genèse de ce cancer. La caractérisation moléculaire du CCR a permis d'identifier les tumeurs par instabiblité génique, appelées MSI (Microsatelite Instability) possédant des anomalies de réparation d'appariement d'ADN
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11

Thornton, Lisa Marie. "Stress and immunity in a longitudinal study of breast cancer patients." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117578022.

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12

Hollingworth, James. "The manipulation of cellular immunity by monoclonal antibodies in cancer patients." Thesis, University of Leicester, 1994. http://hdl.handle.net/2381/34109.

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The role of an immune response in the development and regulation of tumour growth is outlined. The historical development of immunotherapy in the treatment of human cancer is reviewed and the mechanisms by which immunity may be manipulated in vitro and in vivo with respect to improving cancer immunotherapy are discussed. The experimental studies and laboratory methods finally used are presented and validated in chapter 3. Non-major histocompatibility-restricted cellular cytotoxicity was assessed in a standard 4-hour 51chromium-release assay and peripheral blood cell populations were examined u
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13

Maugeri, P. M. "STATES OF CANCER IMMUNITY: THE ETHICAL DIMENSIONS OF HPV VACCINATION POLICIES." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/214786.

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Human Papillomavirus (HPV) is a sexually transmitted virus, recognized to be the necessary, yet not sufficient, cause of cervical cancer. Vaccines for individual administration targeting HPV are available today. In this dissertation I undertake a normative analysis of existing HPV vaccination programmes and evaluate how current policy alternatives put in balance competing moral concerns at stake. To this aim, I explore the ethical dimension of the different policy models, with respect to issues of respect for individual choice, expected coverage rates, and population health goals. My goal is
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14

Seipp, Robyn Patricia. "The role of tapasin and its isoforms in antigen presentation and tumor immunity." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/558.

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Major Histocompatibility Complex (MHC) Class I molecules present peptides to CD8⁺ T cells and are essential for most adaptive immune responses. The first described-spliced tapasin (“isoform 1”) plays a critical role in MHC-I antigen presentation by facilitating peptide loading onto MHC-I molecules in the endoplasmic reticulum (ER). This thesis examines the expression, localization and function of two novel, alternatively-spliced isoforms of human tapasin that lack exon 7 (“isoform 2”) or both exons 6 and 7 (“isoform 3”). Isoform 1 contains a di-lysine ER-retention motif; the two novel isoforms
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15

Darwish, Ammar. "Systemic and mucosal immunity in patients with periampullary cancer, obstructive jaundice and chronic pancreatitis." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/systemic-and-mucosal-immunity-in-patients-with-periampullary-cancer-obstructive-jaundice-and-chronic-pancreatitis(b6e3ee83-3e4e-4b34-8c36-8eb75c3961cc).html.

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Introduction: Derangement of systemic and mucosal immunity, which are the integral components of the immune system, increases the risk of septic complications in patients postoperatively. The aims of this study were to investigate the integrity of systemic immunity as well as the mucosal immune system in patients with pancreatic cancer (PC), chronic pancreatitis (CP) and obstructive jaundice (OJ).Method: Healthy controls, as well as four groups of patients were studied. These included; jaundiced patients with PC, jaundiced patients secondary to benign disease (choledocholithiasis), non-jaundic
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16

Decque, Adrien. "Etude de la SUMOylation dans l’immunité innée et l’oncogenèse." Electronic Thesis or Diss., Paris 6, 2014. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2014PA066312.pdf.

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La SUMOylation est une modification post-traductionnelle réversible permettant de diversifier les fonctions de centaines de substrats. Elle est impliquée dans des processus essentiels à la cellule et à l'organisme, tels que la réparation de l'ADN, la mitose, la transcription. A l'aide de modèles murins génétiquement modifiés déficients pour l'unique enzyme E2 de SUMOylation, UBC9, nous avons caractérisé les conséquences de la réduction de la SUMOylation sur l'immunité innée et l'oncogenèse.Nous révélons un rôle majeur de la SUMOylation dans la régulation négative du gène codant pour l'IFN- . L
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17

Calvet, Christophe. "Immunological aspects of anticancer electroporation-based treatments." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114816.

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L'électrochimiothérapie est un traitement anticancéreux utilisé en routine en Europe dans près de 130 centres de traitement du cancer. Le taux de réponse objective atteint 85 % pour le traitment de tumeurs cutanées et sous-cutanées et des études sont en cours afin d'appliquer ce traitement à des tumeurs profondes. Au cours de ce doctorat, les méchanismes sous-jacents à cette excellente efficacité antitumorale ont été étudiés. Dans un premier temps, l'objectif a été d'évaluer la capacité de l'électrochimiothérapie à induire la mort des cellules souches cancéreuses, considérées comme les racines
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18

Allen, Paul David. "Investigation into the effects of suramin and interleukin-2 on anti-tumour immunity." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309057.

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The use of rhIL-2 to augment antitumour immunity was seen as having great potential for the treatment of neoplasia, but the efficacy of immunotherapy has remained poor despite encouraging experimental data. A reason for this could be active immunosuppression by the tumour mediated by the secretion of suppressor factors. Suramin is a polyanionic drug which blocks and inhibits a range of growth factors and cytokines. This project investigates the potential of suramin to act as an adjunct to rhIL-2 based immunotherapy by acting as a blockade to suppressor factors. In vitro studies showed that rhI
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19

Marcheteau, Elie. "Effet de l'inhibition par ARN interférence de la thrombospondine-1 sur la potentialisation de la réponse immune dans un contexte tumoral." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30083.

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Le cancer du sein est actuellement le cancer le plus fréquent et le plus mortel chez la femme. Malgré le fait que la prise en charge des patientes ait été améliorée dans nos sociétés occidentales au cours des dernières années, la principale cause de mortalité reste la dissémination métastatique. Force est de constater que de nombreuses stratégies thérapeutiques, comme des traitements anti-angiogéniques ou des immunothérapies ciblant des points de contrôle immunitaire, sont toujours en échec dans ce type de cancer, notamment dans les cancers du sein triple négatifs (TNBC), forme la plus agressi
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20

Draganov, Dobrin Draganov. "MFG-E8 Blockade Enhances Tumor Immunity in a Murine Breast Cancer Model." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10512.

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Milk fat globule - epidermal growth factor - factor 8 protein (MFG-E8) is an important mediator of the tolerogenic functions of GM-CSF, and a dominant-negative RGE mutant augments the therapeutic potential of irradiated, GM-CSF-secreting tumor vaccines (GVAX) in the MFG-E8-negative B16 melanoma model. The frequent expression of MFG-E8 in various solid and hematological malignancies, however, prompted us to investigate the effect of the RGE mutant in a MFG-E8-positive transplantable breast tumor model. Here, we report that MFG-E8 blockade augmented anti-tumor humoral responses and modulated imm
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21

Sarvaria, Anushruti. "The differential role of regulatory B cells in cancer and allo-immunity." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/55298.

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A new wave of research recognizes a distinct subset of B regulatory cells (Breg) that maintain immune tolerance. Breg cells have been shown to exert immunoregulatory functions through the production of interleukin (IL)-10 and appear to play important roles in autoimmunity and in cancer. Despite the extensive body of evidence reinforcing the notion of B cells as potential regulatory cells, some controversy over the paucity of markers that can unequivocally identify Bregs still exists. To study the role of Breg in immune surveillance, I designed a comprehensive multi‐parameter panel of surface a
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22

Prat, Mélissa. "Les macrophages au sein du microenvironnement tumoral : étude et modulation des mécanismes moléculaires et cellulaires de la réponse anti-tumorale au cours de carcinoses péritonéales." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30116.

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Les macrophages (Mφs) possèdent une remarquable plasticité phénotypique et fonctionnelle qui leur permet de s’adapter aux différents signaux de leur microenvironnement. Au sein du microenvironnement tumoral, les Mφs ou TAMs (Tumor-associated Mφs) représentent la population leucocytaire majeure. Au cours du développement tumoral, les cellules transformées contribuent à éduquer les TAMs qui acquièrent alors des propriétés permissives à la croissance tumorale. Ainsi, il est aujourd’hui admis que les TAMs, initialement de phénotype M1 anti-tumoral, vont se différencier vers un phénotype M2 capable
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23

Roberts, Mark G. "Investigating the Effects of Nucleosome Remodeling Factor Knockdown on Anti-Tumor Immunity." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4285.

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The nucleosome remodeling factor (NURF) is a chromatin remodeling complex involved in early animal development and is implicated in a number of cancers. In previous work, knockdown of NURF’s largest subunit, BPTF, resulted in diminished tumor growth in mouse cancer cell lines. Other studies in our lab demonstrated increased activation of T-lymphocytes into BPTF KD tumors. In order to examine if this approach has any therapeutic potential, this work investigates the effects of BPTF knockdown in established tumors by using recombinant adenoviruses (rAd), as well as observe the way the immune sys
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24

McLarnon, Andrew. "Cellular mechanisms of alloreactive immunity following stem cell transplantation." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3064/.

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Allogeneic stem cell transplantation is associated with a powerful T cell-mediated ‘graft-versus-leukaemia’ (GvL) effect and also ‘graft-versus-host disease’ (GvHD). Developing therapies to improve survival relies on greater understanding of these responses in order to enhance GvL and suppress GvHD. To gain an increased understanding of the mechanisms of GvHD I measured frequencies of Th1, Th17 and Treg subsets in the blood of 32 GvHD patients (during and outside of disease episodes) and in 21 patients who did not suffer GvHD. No associations between T cell subset frequencies or serum cytokine
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25

Millar, David George. "The role of idiotype-specific immunity in antigen receptor diversity." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/1520/.

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Lymphocytes express antigen receptors which are formed by re-arrangement of gene segments. Mutations acquired during this process, predominantly in the complementarity determining regions (CDRs), result in generation of non-germline sequences. Through analysing the CDR3 sequence, this study attempts to determine whether editing of the lymphocyte repertoire is present in an HLA-dependant manner. Data presented demonstrates a decrease frequency of CDR3-derived HLA-A2 binding peptides in HLA-A2+ donors (0.03% (SYFPEITHI) and 0.35% (BIMAS)) compared with HLA-A2- donors (0.24% (SYFPEITHI, p=0.01) a
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26

Sabbah, Shereen. "T cell immunity to Kaposi’s sarcoma-associated herpesvirus latent proteins." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3273/.

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T cell immunity is important for the control of Kaposi’s sarcoma-associated herpesvirus (KSHV) disease, yet little is known about KSHV-specific immunity in healthy donors. Screening PBMCs from such donors by ELISpot analysis identified weak responses to the KSHV latent antigens; antigens expressed in the virus associated pathologies. We generated T cell clones to the latent proteins LANA and vFLIP and determined whether they recognised target cells. CD8+ clones poorly recognised targets expressing vFLIP or LANA, through mechanisms which reduce target protein synthesis: vFLIP used rare codons i
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27

Pallan, Lalit. "Investigating T cell immunity against the oncogenic Merkel cell polyomavirus." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7165/.

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Merkel cell polyomavirus (MCV) is a causative factor in Merkel cell cancer (MCC). This aggressive skin maligrancy is associated with UV-light exposure, ageing or immunosuppression, implying immune constraint of MCC development. We examined immune control over MCV in MCC patients by comparing immune parameters with donor groups who share risk factors alongside healthy controls. This showed MCC patients had frequent and strong MCV antibody responses but no differences in responses to other polyomaviruses suggesting no general defect in humoral immunity to these viruses. MCC patients had lower fr
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28

Williams, Marc Adrian. "A study of granulocyte-macrophage colony stimulating factor and the immunological function of the monocyte against malignancy and infection." Thesis, Queen Mary, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367835.

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29

Ahmed, Jahangir. "Optimisation of the Lister strain of vaccinia virus for use as an anticancer immunotherapeutic agent." Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9519.

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The premise of this project was to engineer a novel viral platform with the capacity to enhance antitumour immunity. To this effect, the N1L gene was disrupted in a Lister strain vaccinia viral backbone that had previously been engineered to be tumour selective (VVL15ΔN1L) and armed with transgenes encoding murine and human versions of GMCSF and IL12. In vitro, they retained potency for infecting, replicating in and killing a panel of murine, Syrian hamster and human cancer cells; all viruses were able to express their transgenes to detectable levels upon infection of every tumour cell line. I
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30

Leppänen, J. (Joni). "The role of hypoxia, innate immunity receptors and stromal response in pancreatic cancer." Doctoral thesis, Oulun yliopisto, 2019. http://urn.fi/urn:isbn:9789526221809.

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Abstract Pancreatic cancer remains one of the deadliest malignancies, with dismal prognosis. Pancreatic cancer arises from precursor lesions called pancreatic intraepithelial neoplasia. Toll-like receptors (TLR) are receptors of the innate immunity responsible for initiating immune responses against invading pathogens. Their involvement in cancer progression is becoming evident. Hypoxia is a typical characteristic of pancreatic cancer and linked to poor prognosis. Typically, pancreatic cancer has an abundant desmoplastic stroma that contributes to the hypoxia and poor delivery of anti-tumor dr
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31

Bergin, Stephen Michael. "Hypothalamic brain-derived neurotrophic factor regulates lymphocyte immunity, energy balance, and cancer progression." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487669797216355.

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32

Rothschilds, Adrienne Marie. "Engineering protein-based modulators of allergic, temporal, and checkpoint blockade anti-cancer immunity." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/123064.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 128-137).<br>Effective cancer treatment of the future requires incorporating diverse and innovative aspects of immunity to fight against cancer, accounting for pharmacokinetic and temporal barriers of therapeutics, and engineering approaches to understand and improve upon current immunotherapies. This thesis addresses these challenges in three projects utilizing the Wittrup Lab's quantitative, engineering approa
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Mansi, Laura. "Intégration de l’analyse de l’immunomodulation induite par les inhibiteurs de mTOR dans leur développement en cancérologie." Thesis, Bourgogne Franche-Comté, 2017. http://www.theses.fr/2017UBFCE012.

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Le rôle central de la voie mTOR (mammalian Target Of Rapamycin) dans l’homéostasie cellulaire suscite un réel intérêt dans de nombreux domaines thérapeutiques. Les inhibiteurs de mTOR (mTORi) sont utilisés en prévention du rejet de greffe par leur action d’inhibition de l’activation lymphocytaire T et l’induction de lymphocytes T régulateurs (Treg). En cancérologie, les mTORi sont utilisés pour leur action anti-proliférative et anti-angiogénique. Cependant, l’efficacité clinique de ces traitements reste modeste. Bien que des mécanismes de résistance aux mTORi intrinsèques à la cellule tumorale
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34

Janho, Dit Hreich Serena. "Rôle de l'immunomodulateur P2RX7 dans le cancer et la fibrose pulmonaire." Electronic Thesis or Diss., Université Côte d'Azur, 2022. http://www.theses.fr/2022COAZ6020.

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Malgré de nouvelles connaissances biologiques et des avancées thérapeutiques récentes, les cancers du poumon sont encore la première cause de décès liés au cancer alors que la fibrose pulmonaire idiopathique est incurable. Il est donc urgent d'élaborer de nouvelles approches pour aider les patients atteins de ces pathologies.P2RX7 est un récepteur canal activé par de fortes concentrations d'ATP extracellulaire (ATPe), concentrations retrouvées dans les tissus tumoraux et fibreux. Il joue un rôle majeur dans la modulation du système immunitaire par sa capacité à activer l'inflammasome NLRP3 et
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Sfondrini, Lucia. "Enhancement of anti-tumour immunity by transduction with a Mycobacterium tuberculosis gene." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342892.

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36

Peng, Judy Chun-Ju. "Optimization of Dendritic cells for cancer immunotherapy /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18443.pdf.

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37

Clever, David C. Clever. "T Cell-Intrinsic PHD Proteins Regulate Pulmonary Immunity." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471868519.

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38

Bingula, Rea. "Non-small cell lung cancer, immunity and microbiota : laying ground for the gut-lung-lung cancer axis in human subjects." Thesis, Université Clermont Auvergne‎ (2017-2020), 2019. http://www.theses.fr/2019CLFAS009.

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Le cancer du poumon est la principale cause de décès par cancer dans le monde. En dépit de la variété de traitements disponibles, tels que la chirurgie, la chimiothérapie, la radiothérapie et l’immunothérapie, la survie moyenne à 5 ans est de 60 %. L’une des raisons sous-jacente est une très grande variabilité de réponse au traitement, expliquée par les antécédents génétiques du patient et depuis peu par son microbiote. Le terme « microbiote » regroupe les bactéries, les archées, les champignons, les virus et les protistes qui colonisent notre organisme. Des études utilisant des modèles animau
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O'Hara, Richard James. "Interleukin-12 a pivotal cytokine in cell mediated immunity : the role in colorectal cancer." Thesis, University of Hull, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395426.

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40

Moynihan, Kelly D. (Kelly Dare). "Engineering immunity : enhancing T Cell vaccines and combination immunotherapies for the treatment of cancer." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/113960.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2017.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 127-140).<br>Checkpoint blockade with antibodies against CTLA-4 or PD-1 has demonstrated that an endogenous adaptive immune response can be stimulated to elicit durable tumor regressions in metastatic cancer, but these dramatic responses are confined to a minority of patients¹-³. This outcome is likely due in part to the complex network of immunosuppressive pathways present in advanced tumors, which necessitate
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41

Namjoshi, Prachi Mukund. "Th-1 Cytokine and Antibody Mediated Immunity against HER Family Expressing Breast Cancer Cells." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1461250751.

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42

Zhao, Junjie. "MECHANISMS OF SINGLE IG IL-1-RELATED RECEPTOR MEDIATED SUPPRESSION OF COLON TUMORIGENESIS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459761067.

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43

Zheng, Ying, and 鄭盈. "A complementary activation of peripheral NK cell immunity in EBV related nasopharyngeal carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B34605162.

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44

Grandal, Rejo Beatriz. "Beyond Breast Cancer : The Interplay of Immunity, Comedications, and Comorbidities in Treatment Response and Outcomes." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASL063.

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Le cancer a provoqué près de 10 millions de décès en 2020, il est prévu qu'il affectera presque 24,5 millions de personnes d'ici 2035 en raison des changements de mode de vie, du vieillissement et des facteurs environnementaux. Le cancer du sein (CS) est le diagnostic de cancer le plus fréquent et la première cause de mortalité oncologique chez les femmes. L'incidence du CS s'accroît avec l'âge, en parallèle avec la prévalence croissante des conditions concomitantes (comorbidités) et des prescriptions de médicaments chroniques (comédications), signalées chez environ la moitié de tous les patie
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45

Do, Priscilla. "Immune Attunement: Fortifying Anti-Tumor Immunity Via T Cell Co-Stimulation." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492568422442233.

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46

Bonsang-Kitzis, Hélène. "Caractérisation moléculaire et immunité des cancers du sein triple-négatifs." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS162.

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Le cancer du sein triple négatif (CSTN) est le sous-type de cancer du sein le plus hétérogène et le plus défavorable. La pierre angulaire du traitement de ces tumeurs repose sur la chimiothérapie systémique, de plus en plus fréquemment administrée en néoadjuvant, puisqu’aucune thérapie ciblée n’est à ce jour validée. L'obtention d'une réponse complète histologique (RCH) constitue un marqueur pronostique favorable majeur ainsi qu'un test in vivo de la sensibilité aux médicaments anti-tumoraux. L’objectif de notre travail de thèse a donc été d’apporter des éléments de compréhension de cette hété
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47

Jacqueline, Camille. "Communautés d’agents infectieux et incidence des cancers : le rôle de l’écologie du système immunitaire." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT066.

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Le cancer est un problème majeur en santé humaine représentant l’une des principales causes de décès dans le monde. Depuis le début du 20ème siècle, le parasitisme a émergé comme un facteur déterminant pour expliquer la vulnérabilité face au cancer, avec un nombre croissant d’agents infectieux reconnus comme oncogènes. En parallèle, les virus oncolytiques ont attiré une attention considérable pour leur intérêt thérapeutique. Cependant, le rôle des autres agents infectieux dans le développement du cancer est resté largement inexploré même s’ils sont l’un comme l’autre soumis aux pressions du sy
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48

Yi, Xin. "RNASE L MANIPULATES MACROPHAGES IN INNATE IMMUNITY AND TUMOR GROWTH." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1342151674.

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Kerr, J. P. "Cytotoxic T cell costimulation : biology and potential for generating long-lasting immunity." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/375471/.

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50

Wu, Salene M. "Relationship of General and Health-related Anxiety and Worry to Markers of Inflammation in Women with Advanced Cancer." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1356624916.

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