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Dissertations / Theses on the topic 'Cancer microenvironment'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Zhang, Xiao Mei. "Tumour Microenvironment, Cancer Stem Cells and Radiation Response in Oropharyngeal Cancer." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14476.

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The incidence of Human papillomavirus (HPV) induced oropharyngeal squamous cell carcinoma (OSCC) is rising. HPV-positive OSCC is associated with a favourable prognosis, the mechanism is not fully understood and could be related to intrinsic radiosensitivity of the HPV-positive OSCC. The aim of this candidature was to study the influence of tumour microenvironment on radiosensitivity by examine HIF-1α in OSCC and by using in vitro 3D tumour models. The main finding of the HIF-1α study was the HPV status remains the strongest prognostic factor in OSCC. Hypoxia might be an important factor in HP

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2

Ho, Victor Wing Heng. "Manipulating the tumor microenvironment to slow cancer growth." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42239.

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The tumor microenvironment encompasses all of the factors and accessory cells which interact with a tumor and, more often than not, are co-opted by tumor-secreted factors to help the cancer grow. In this thesis, we examined elements of the tumor microenvironment, specifically the cancer-promoting M2 macrophages (MΦs) and tumor glucose supply and metabolism. In the vast majority of advanced cancer patients and tumor-bearing animals, their tumors contain MΦs that are profoundly skewed to a cancer-promoting M2 phenotype, which often correlates with a poor prognosis. As well, these same tumor tiss

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3

Pepin, Francois. "Bioinformatics approaches to understanding the breast cancer microenvironment." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92240.

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Breast cancer is a complex disease that requires the acquisition of several traits in order to proliferate and spread to nearby and distant tissues. However, many combinations are possible, making it harder to determine their significance. Genome-wide approaches such as gene expression profiling have provided an unbiased and global tool to investigate those traits, allowing investigators to both separate tumors into biologically meaningful categories and then to investigate their features in that context. A well-organized effort is required in order to collect and analyze the large number of s

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4

Jiménez, Sánchez Alejandro. "Characterisation of the tumour microenvironment in ovarian cancer." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/287935.

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The tumour microenvironment comprises the non-cancerous cells present in the tumour mass (fibroblasts, endothelial, and immune cells), as well as signalling molecules and extracellular matrix. Tumour growth, invasion, metastasis, and response to therapy are influenced by the tumour microenvironment. Therefore, characterising the cellular and molecular components of the tumour microenvironment, and understanding how they influence tumour progression, represent a crucial aim for the success of cancer therapies. High-grade serous ovarian cancer provides an excellent opportunity to systematically

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5

Hodkinson, Philip Simon. "Tumour microenvironment interactions of small cell lung cancer." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4254.

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Small cell lung cancer (SCLC) is characterised by rapid growth, early metastatic spread and poor long-term survival. The tumour is initially sensitive to chemotherapy and thus objective response rates are high. Unfortunately, this response is often short-lived and SCLC recurs with acquired drug resistance, resulting in early patient death. Despite intensive chemo- and radiotherapy regimes survival has not improved significantly in 20 years. Prior research suggests a critical role for the tumour microenvironment in the pathogenesis of other cancers. Therefore, investigating interactions between

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6

mattei, gianluca. "Tumor Microenvironment: Bioinformatics and Systems Biology Approaches." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1070301.

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Cancers develop in complex microenvironments whose importance was emerging during last years. In fact, cancer microenvironment influences tumor progression and leads to the raising of chemotherapics resistance. Thus, a shift of the focus from cancer cells to cancer cells in their environment is crucial for studying the molecular and metabolic features of tumors in physiological contexts. Within the microenvironment, cancer associated fibroblasts (CAF) are attracting the attention of scientific community since, up to date, it is clear that they are the main component involved in the organizatio

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7

Mendoza, Erin. "Role of p53 in Adaptation to the Tumor Microenvironment." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/204113.

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Tumors cells grow in nutrient and oxygen-deprived microenvironments and adapt to the suboptimal growth conditions by altering their metabolic pathways. The adaptation process commonly creates a tumor phenotype of high glycolytic potential and aggressive growth characteristics which facilitate metastasis and confer resistance to radiation and chemotherapy. Understanding the mechanisms that allow tumors to adapt and survive in their microenvironment is crucial to cancer prevention and control. It was hypothesized that the tumor microenvironment would induce signaling and enzymatic changes, whi

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8

Lal, Neeraj. "Exploring immunogenomic influences on the microenvironment of colorectal cancer." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7601/.

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This thesis focussed on the immunobiology of colorectal cancer (CRC). It explored the role of the γδ T cell ligand Endothelial Protein C Receptor (EPCR) in tumourigenesis, and subsequently characterised the relationship between intra-tumoural immunity and tumour genetics. In silico analyses and immunohistochemistry indicated EPCR was commonly overexpressed in epithelial cancers including CRC. EPCR was upregulated due to gene amplification and DNA hypomethylation alongside neighbouring genes on chromosome 20q, a region previously implicated in tumourigenesis. These results clarify why EPCR is u

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9

Reticker-Flynn, Nathan Edward. "Engineered approaches to querying the microenvironment of cancer metastasis." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/101851.

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Thesis: Ph. D. in Biomedical Engineering, Harvard-MIT Program in Health Sciences and Technology, 2013.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 165-191).<br>Cancer metastasis is the underlying mechanism of 90% of cancer-related deaths, yet few therapeutics exist that directly target it. Part of this scarcity is attributable to a general lack of knowledge with regards to the underlying mechanisms that mediate traversal of the sequential steps required for malignant dissemination. Recently, biologists and clinicians have gained appreciation for the r

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10

Neisen, Jessica. "Chemokine regulation of microenvironment-enhanced invasion in prostate cancer." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677956.

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The interaction between a tumour and the surrounding non-malignant stroma impacts on nearly every aspect of malignant progression. The heterogeneity of the tumour microenvironment (TME), however, makes mapping this interaction difficult. Each stromal population contributes to various functions and each tumour type has its own distinct pathway of interaction with different stromal populations. The majority of these interactions are mediated by soluble factors secreted into the TME. The aim of this study was to elucidate the role that IL-8 signalling may play in prostate tumour interaction with

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11

Pham, Hoang Son. "Membrane Heparan Sulfate Proteoglycans in the breast cancer microenvironment." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/212715/1/Hoang%20Son_Pham_Thesis.pdf.

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This project investigated the role of the cellular microenvironment in regulating human breast cancer (BC) models by examining members of the Heparan Sulfate Proteoglycan (HSPG) family of glycoproteins. Small interfering RNAs were used to in vitro to inhibit HSPG gene expression and examine effects on target gene expression, cell proliferation and cell migration in BC cell lines. Findings suggested HSPGs (i.e., Sydencan 1/4, SDC1/4) promote BC proliferation via Akt/Wnt signalling and also influence BC cell migration. As such the SDC1/4 HSPGs can be considered as potential biomarkers for the ea

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12

D'Angelo, Edoardo. "Decellularized colorectal cancer matrix as bioactive microenvironment for in vitro 3D cancer research." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3426811.

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Three-dimensional (3D) cancer models are overlooking the scientific landscape with the primary goal of bridging the gaps between two-dimensional (2D) cell cultures, animal models and clinical research. In this thesis, we describe an innovative tissue engineering approach applied to colorectal cancer (CRC) starting from decellularized human biopsies in order to generate an organotypic 3D bioactive model. This in vitro 3D system recapitulates the ultrastructural environment of native tissue as demonstrated by histology, immunohistochemistry, immunofluorescence and scanning electron microscopy an

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13

Angell, Helen K. "Immune modulation of the tumour microenvironment." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12641/.

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Regulatory T cells (Tregs) are a distinct lymphocyte lineage, functionally defined as T cells that inhibit an immune response, which is crucial for maintaining peripheral tolerance and the prevention of autoimmunity. Tregs have been implicated in tumour immune evasion, suppressing the anti-tumour immune response, resulting in tumour progression. The aim of this PhD was to recognise how Tregs function and understand how they are able to modulate tumour immunology. In order to research their proposed role in cancer, it was necessary to be able to phenotype, sort and expand functional Tregs. In p

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14

Daukšte, Liene. "Mathematical Modelling of Cancer Cell Population Dynamics." Thesis, University of Canterbury. Mathematics and Statistics, 2012. http://hdl.handle.net/10092/9356.

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Mathematical models, that depict the dynamics of a cancer cell population growing out of the human body (in vitro) in unconstrained microenvironment conditions, are considered in this thesis. Cancer cells in vitro grow and divide much faster than cancer cells in the human body, therefore, the effects of various cancer treatments applied to them can be identified much faster. These cell populations, when not exposed to any cancer treatment, exhibit exponential growth that we refer to as the balanced exponential growth (BEG) state. This observation has led to several effective methods of estimat

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15

McCloskey, Curtis. "Exploring the Tumor and Premetastatic Microenvironment of the Ovary." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38624.

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Ovarian cancers are the most lethal gynecological malignancies, responsible for more than 150,000 deaths around the globe annually. Among ovarian cancers, high-grade serous ovarian cancer has a 5-year survival rate of only 40%. This poor survival is due to a widespread lack of understanding of this disease, from suboptimal prevention and screening methods to failures in treatment. Moving towards novel prevention and treatment methods requires better models of ovarian cancer that phenotypically and genetically recapitulate the features of ovarian cancers that are seen clinically. This thesis hi

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16

Mota, Fernando Luis da Cruz Fernandes. "The immune microenvironment in HPV-related cervical neoplasia." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287582.

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17

Kovacheva, V. N. "Modelling and analysis of the tumour microenvironment of colorectal cancer." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/77506/.

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New bioimaging techniques have recently been proposed to visualise the colocation or interaction of several proteins within individual cells, displaying the heterogeneity of neighbouring cells within the same tissue specimen. Such techniques could hold the key to understanding complex biological systems such as the protein interactions involved in cancer. However, there is a need for new algorithmic approaches that analyse the large amounts of multi-tag bioimage data from cancerous and normal tissue specimens in order to begin to infer protein networks and unravel the cellular heterogeneity at

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18

Tam, Christine. "Defining microenvironment-induced transcription profiles in breast cancer liver metastases." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123094.

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Breast cancer is the most common type of cancer diagnosed in Canadian women, with metastatic spread contributing to the majority of cancer-related deaths. The liver is the third most frequent site of breast cancer metastasis, but not much is known about the hepatic microenvironment's role in regulating the growth and survival of metastatic cells in the liver. In order to elucidate these interactions, we used laser capture microdissection and microarray analysis to compare gene expression patterns of liver metastases and primary tumors. We employed liver-aggressive 4T1 breast cancer cells deriv

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19

Werbeck, Jillian Lee. "Genetic Contributions of the Tumor Microenvironment in Breast Cancer Metastasis." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306436090.

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20

Kurtinović, Andrea. "Exploring the tumor microenvironment to improve immunotherapy for bladder cancer." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-366582.

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Bladder cancer, as one of the most common cancer types and with high recurrence risk, is considered a candidate for novel immunotherapy strategies. An important aspect of the research for immunotherapy drug development for bladder cancer is to study the tumor microenvironment (TME) and it’s immune contexture. Besides tumor-infiltrating lymphocytes (TILs) as the main drivers of anti-tumor response, recent studies revealed the importance of tumor-associated tertiary lymphoid structures (TLSs) and high endothelial venules (HEVs) in the TME. Structures similar to these were found to spontaneously

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21

YOUSAFZAI, MUHAMMAD SULAIMAN. "Cancer cell mechanics and cell microenvironment: An optical tweezers study." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908097.

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Since cancer metastasis is a complex process, lot of research has been carried out to identify different hallmarks for its diagnosis and cure. Mechanical alterations in cancer cells during cell spreading to adjacent tissues and other organs of the body emerged as a prominent hallmark in the last decade. In this thesis we employed a mechanistic approach and used stiffness (elasticity) as a marker to study cell’s mechanical response in varying microenvironmental conditions. Cell– microenvironment mechanical interaction is a blend of cell-matrix and cell-cell interactions. Therefore we adopted

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22

TOTI, ALESSANDRA. "TUMOUR MICROENVIRONMENT: PROTEIN MEDIATORS OF INTERCELLULAR CROSSTALK." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1070249.

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Tumor progression is not only due to the aggressiveness of cancer cells but also to the support given by tumour reactive stroma; reason why the study of stromal cell involvement in tumor microenvironment has become extremely important in the last decades. Tumor mass is a complex network of cancer and stromal cells, and fibroblasts are the main component. Under the influence of tumor cells, fibroblasts engage a transdifferentiation program converting them into their active form (myofibroblast), the so called cancer associated fibroblasts (CAFs), that, in turn, are able to enhance tumor cells gr

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23

Perera, Mihindukulasuriya Weliweriyage Sumeth. "Regulation of exosome secretion and functions by mTORC1 signalling and the microenvironment." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:78e423ad-226a-40b5-8010-350d872097a8.

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Cancer cells require survival strategies to respond to microenviromental changes and out-compete their neighbours. They activate stress response mechanisms under extreme microenvironmental conditions, some of which are controlled by the amino acid-sensitive kinase complex, mechanistic Target of Rapamycin Complex 1 (mTORC1). Exosomes are secreted nanovesicles made inside intracellular endosomal compartments that mediate a specialised and complex form of intercellular signalling that can reprogramme target cells via the action of multiple active cargos. I investigated whether mTORC1 activity mig

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24

Benard, Audrey. "IR imaging in breast cancer: from histopathological recognition to characterization of tumour microenvironment." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209682.

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Breast cancer is a global public health problem since it is the most frequently diagnosed cancer in women in Western countries. Clinical guidelines for breast cancer prognosis/diagnosis are currently based on tumour size, histological type and grade, lymph node status as well as the expression of various cellular receptors. Yet, current predictions remain unsatisfactory to identify the best treatment for the individual patient. The search for identifying new predictive and prognostic factors is ongoing. Furthermore, compelling evidences have solidified the notion that the evolving epithelial c

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25

O'Connor, John C. "The role of the bone microenvironment in prostate cancer bone metastasis." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 271 p, 2007. http://proquest.umi.com/pqdweb?did=1394657781&sid=14&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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26

Fong, Jenna. "Breast cancer cells affect bone cell differentiation and the bone microenvironment." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104758.

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Breast carcinoma is the most commonly diagnosed cancer among women worldwide, with approximately 1 in 7 expected to be affected during her lifetime. The spread of breast cancer to secondary sites is generally incurable. Bone is the preferred site of metastasis, where the development of a secondary tumour causes severe osteolysis, hypercalcemia and a considerable pain burden. However, how breast cancer cells establish supportive interactions with bone cells is not well understood. We have examined the effects of factors released from MDA-MB-231 and 4T1 breast cancer cells on the differentiation

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Haider, Marie-Therese. "The tumour microenvironment as a potential therapeutic target in breast cancer." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/15729/.

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Increasing evidence suggests that breast cancer (BC) progression involves interaction between the tumour and the surrounding stroma, the tumour microenvironment (TME). Work presented in this thesis is based on the hypothesis that anti-cancer therapies influence the bone microenvironment (BME), contributing to enhanced treatment efficacy. Thus, the BME was established as a therapeutic target for BC using in vivo models, imaging and molecular analysis. Novel evidence of early effects of the bisphosphonate Zoledronic acid (ZOL) on cells other than the osteoclast, its main target, are presented. I

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Truong, Danh, Julieann Puleo, Alison Llave, Ghassan Mouneimne, Roger D. Kamm, and Mehdi Nikkhah. "Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment." NATURE PUBLISHING GROUP, 2016. http://hdl.handle.net/10150/621806.

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In this study, to model 3D chemotactic tumor-stroma invasion in vitro, we developed an innovative microfluidic chip allowing side-by-side positioning of 3D hydrogel-based matrices. We were able to (1) create a dual matrix architecture that extended in a continuous manner, thus allowing invasion from one 3D matrix to another, and (2) establish distinct regions of tumor and stroma cell/ECM compositions, with a clearly demarcated tumor invasion front, thus allowing us to quantitatively analyze progression of cancer cells into the stroma at a tissue or single-cell level. We showed significantly en

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Cohen, Courtney Alicia. "The Omental Fat Band as an Immunomodulatory Microenvironment for Ovarian Cancer." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/50968.

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Cancer research is evolving. Historically concerned with the mechanisms by which malignant cells circumvent cell death signaling and maintain unchecked proliferation, focus has shifted to the complex interactions between the tumor cell and the surrounding microenvironment. Ovarian cancer has one of the highest incidence-to-death ratios of all cancers, and is typically asymptomatic until the later stages, often resulting in metastasis prior to discovery. Naturally occurring phenotypes like lactation and child-bearing (parity) reduce ovarian cancer incidence, but the mechanisms are not understoo

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Celesti, G. "MESENCHYMAL FEATURES MEDIATED BY TWIST1 IN COLORECTAL CANCER CELLS AND MICROENVIRONMENT." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/158084.

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Background. Colorectal cancer (CRC) is a major cause of death for cancer in western countries, ranking third in both sexes. Therapeutic developments in the past decades have extended life expectancy in patients with advanced disease (i.e., stage III), and even for those with distant metastasis (i.e., stage IV). Most treatments for advanced disease nowadays include a combination of chemotherapy with target therapy. Despite advances, the fact that metastatic colorectal cancer remains largely incurable, pushes to pursue a better understanding of the factors underlying cancer progression. Nowadays

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Zajac, Olivier. "Cancer associated fibroblasts stimulate cancer resistance to therapy." Electronic Thesis or Diss., Université Paris sciences et lettres, 2024. http://www.theses.fr/2024UPSLS001.

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Les patients atteints d'un cancer du rectum localement avancé reçoivent généralement une chimioradiothérapie à base de 5-FU et de radiation. Cependant, seulement 10 à 30 % d'entre eux obtiennent une réponse complète au traitement avec une excellente survie à long terme. En plus de la résistance inhérente des cellules cancéreuses au traitement, le microenvironnement de la tumeur semble jouer un rôle crucial dans a réponse tumorale. Les fibroblastes associés au cancer (CAFs), les cellules non cancéreuses prédominantes dans le cadre de la tumeur, sont organisés autour des cellules cancéruses et,

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Jaeschke, Anna. "Dissecting the role of tissue-specific cancer-associated fibroblasts in the prostate tumour microenvironment." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/212448/1/Anna%20Jaeschke%20Thesis.pdf.

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Much of what we know today about prostate cancer is derived from studying cancer cells grown on a 2D plastic substrate, not representing the complex structure of a three-dimensional tumour. In this work, bioengineered cancer models provided physiologically relevant research platforms to gain novel insights into the interactions between different cell types present in the tumour. Distinct features of the cancerous and healthy tissues were found that have the potential to be explored for new diagnostic approaches. Advanced toolkits were developed to support the use of bioengineered models to the

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Chauhan, Vikash Pal Singh. "Re-Engineering the Tumor Microenvironment to Enhance Drug Delivery." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10405.

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Tumors are similar to organs, with unique physiology giving rise to an unusual set of transport barriers to drug delivery. Cancer therapy is limited by non-uniform drug delivery via blood vessels, inhomogeneous drug transport into tumor interstitium from the vascular compartment, and hindered transport through tumor interstitium to the target cells. Four major abnormal physical and physiological properties contribute to these transport barriers. Accumulated solid stress compresses blood vessels to diminish the drug supply to many tumor regions. Immature vasculature with high viscous and geomet

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Confeld, Matthew Ian. "A Nano-Sized Approach to Exploiting the Pancreatic Tumor Microenvironment." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/31354.

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Ito, Koichi. "Galectin-1 as a Potent Target for Cancer Therapy: Role in the Tumour Microenvironment." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/367472.

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Despite many new and significant discoveries made in cancer research in the last few decades, only limited improvements in overall responses to treatment have occurred. The frustrating gaps between the scientific evidence and minor advances in clinical outcomes as well as unacceptable treatment failure must be overcome by improving current cancer therapies and developing more effective anti-cancer strategies. The term “tumour heterogeneity” refers to the formation of a tumour containing areas with distinguishable phenotypic features within its microenvironment. The realisation that a tumour ti

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Wells, Richard John Beringer. "A characterisation of the tumour microenvironment in murine pancreatic cancer as a target for combination immunotherapy." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708779.

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Sundquist, E. (Elias). "The role of tumor microenvironment on oral tongue cancer invasion and prognosis." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526217659.

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Abstract Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity. The 5-year mortality of OTSCC remains at about 50%. The tumor microenvironment (TME) is now recognized as an important factor in cancer progression and metastasis, as well as a tool for prognostication. The aim of this study was to elucidate the roles of TME hypoxia and soluble factors on cancer cell migration and invasion, and the prognostic value of two extracellular matrix (ECM) molecules: tenascin-C (TNC) and fibronectin (FN). Hypoxia was studied using oral squamous cell carcinoma cells in mi

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Cadassou, Octavia. "Cancer and microenvironment : the functional interplay between intra- and extracellular nucleotide metabolisms." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1189/document.

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Les nucléotides jouent un rôle majeur dans une pléiade de processus biologiques comme la composition des acides nucléiques, la signalisation, ou la régulation de la balance énergétique. Les nucléotides extracellulaires exercent également des fonctions biologiques. Par conséquent, des dérégulations des pools de nucléotides impactent l’homéostasie de multiples façons, par exemple en promouvant l’instabilité génétique ou un environnement immunosuppresseur. Or, ces paramètres font partie des « Hallmarks du Cancer » décrits par Hanahan et Weinberg. Ces observations confirment l’éventualité d’un rôl

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Rees, Peter Adam. "The role of extrinsic clotting pathway activation in the colorectal cancer microenvironment." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-extrinsic-clotting-pathway-activation-in-the-colorectal-cancer-microenvironment(3249687f-147d-4a41-9ca1-76471e9baac1).html.

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Malignancy is associated with a hypercoagulable state manifested clinically by an increased incidence of venous thromboembolism (VTE). Colorectal cancer (CRC) patients who develop VTE have reduced survival. This increased mortality extends beyond the acute VTE event, suggesting that VTE is associated with aggressive tumour biology. Tissue factor (TF) and other clotting factors have been implicated in this process. However, the significance of clotting factors in the tumour microenvironment (TME) remains unknown. The aim of this thesis is to i) determine if a procoagulant TME is a biomarker for

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Entenberg, David. "Enabling research into the tumour microenvironment : novel photonics assays for cancer research." Thesis, University of Kent, 2018. https://kar.kent.ac.uk/70176/.

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Physics and engineering principles have long been applied to the development of instrumentation and assays that have significantly advanced biological research. In particular, photonics based instruments and assays have proven to be powerful tools that enable researchers to investigate biological processes in vivo. The research described in this thesis covers a range of photonics based instruments and assays that expand the capabilities researchers have to investigate challenging biological problems. These advances give researchers new tools for directly visualising dynamic biological events i

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Balanis, Nikolas G. "DIVERSE ROLES FOR EGF RECEPTOR SIGNALING IN THE BREAST CANCER TUMOR MICROENVIRONMENT." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1371572946.

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Ramos, Rodrigo Nalio. "The immunosuppressive microenvironment in cancer : local and systemic effects on patients' monocytes." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10270.

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Chez les patients atteints de cancer, les cellules néoplasiques échappent au contrôle du système immunitaire en raison de leur faible immunogénicité et d'une capacité exacerbée à moduler le micro-environnement. Nous décrivons ici les effets de ce micro-environnement tumoral sur la différenciation locale et systémique des monocytes et l'impact de la présence de Macrophages-Associés aux Tumeurs (TAM) CD163+ sur la survie des patientes atteintes de cancer du sein. Par une analyse de cytométrie en flux, nous décrivons un composition hétérogène des sous-types de TAM CD163low et CD163high, où nous a

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Hoffmann, Caroline. "Dendritic Cells in Head and Neck Cancer Microenvironment : From Mechanisms to Biomarkers." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS308/document.

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L’objectif de ce travail était de comprendre l’état moléculaire des cellules dendritiques (CD) dans le microenvironnement tumoral. En intégrant l’analyse de tumeurs humaines par cytométrie en flux, de transcriptome, de secretome tumoral et l’analyse d’une base de données d’interaction CD-lymphocyte T générées in vitro, j’ai obtenus 2 résultats majeurs. Tout d’abord, nous proposons une nouvelle classification de CD activées humaines, qui sont soit « secrétantes », c’est-à-dire spécialisées dans la production de cytokines et chemokines, soit « aidantes » c’est-à-dire spécialisées dans l’inductio

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MINOLI, LUCIA. "TUMOR MICROENVIRONMENT IN EXPERIMENTAL PRECLINICAL MOUSE MODELS OF HUMAN CANCER: MORPHOLOGICAL APPROACH." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/704551.

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One of the recent advancements in oncological research has been the recognition of the tumor microenvironment (TME) as a relevant participant during all stages of the evolution of a neoplastic process. Indeed, over the past decades, tumors have been considered through a changing perspective: no longer as a growth of homogeneous neoplastic cells, but as an actual organ composed of different cell populations and structures: the parenchyma being the neoplastic population and the stroma, including the vascular network and infiltrating cells. The tumor microenvironment has a dual role in tumor biol

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Ahmady, Farah. "The role of immune cells in ovarian cancer." Thesis, Federation University Australia, 2022. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/184111.

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Ovarian cancer remains the leading cause of gynaecological disease related death in women worldwide. Patients given standard treatment have low survival rates and immunotherapy remains unsuccessful. This is largely due to the suppressive tumour microenvironment (TME) and the interaction of the different cells being poorly understood. This has sparked interest in understanding the functions of immune cells and their contribution to the TME. In chapter 3, B and T cells were characterised in samples collected from chemo-naïve highgrade serous ovarian cancer (HGSOC) patients and compared to benign

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Seehawer, Marco [Verfasser], and Lars [Akademischer Betreuer] Zender. "Necroptosis microenvironment directs lineage commitment in liver cancer / Marco Seehawer ; Betreuer: Lars Zender." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1200916948/34.

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Hsia, Lin-Ting. "Identification and characterisation of myofibroblast markers in human colon and colorectal cancer microenvironment." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:dbd04889-9e7d-4175-90bb-aabb09dd21c9.

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Myofibroblasts (MFs) are one of the most significant stromal cell types in epithelia such as in the gut. They play an important role in regulating the normal colorectal stem cell niche and facilitating tumour initiation, growth and progression through inter-cell signalling. Abundant presence of MFs is often associated with poor prognosis in cancers. The aim of this project is to identify new myofibroblast markers to distinguish them from others cells in the stroma, and also to establish patterns of myofibroblast gene regulation. First, we identify the membrane protein that home-raised IgG1 ant

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Bergomas, Francesca. "Tertiary lymphoid tissue in colorectal cancer : a key player of the immune microenvironment." Thesis, Open University, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701365.

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Tumour infiltrating Iymphocytes influence colorectal cancer (CRC) progression. However, Iymphocyte infiltration comes in different flavours and evidence has been provided that the spatial distribution of immune cells within the tumour tissue is an important immunological feature. The aim of this thesis was to investigate how the dual localization of tumour infiltrating Iymphocytes (TILs) can affect their function in the tumour microenvironment. The project started with the analysis of the CD3 compartment, as CD3+ T cell infiltration (C03-TILs) is a recognized positive prognostic factor for CRC

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Pearce, Janina V. "The Role of Tumor and Tumor Microenvironment on Breast Cancer-Associated Adipocyte Plasticity." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5933.

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Cancer-associated cachexia is a condition defined by a sustained net-negative energy imbalance. Although the different types of adipose tissue – white, beige, and brown – have been implicated in contributing to cancer-associated cachexia, the mechanisms of these maladaptive changes and their impact on whole-body energy expenditure have not been fully elucidated. Using breast cancer as our model, we demonstrate white adipose tissue browning in murine and human breast cancer; furthermore, we demonstrate that this effect is extremely localized and takes place early in tumor progression. We utiliz

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Cartaxo, Ana L. "Tumor microenvironment models: ex vivo, in vitro and in silico approaches to address targeted therapies." Doctoral thesis, Universidade Nova de Lisboa, Instituto de Tecnologia Química e Biológica António Xavier, 2020. http://hdl.handle.net/10362/105645.

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"Cancer is the second leading cause of mortality worldwide, despite the extraordinary advances in the last two decades due to the development of targeted therapies. These target particular molecules required for cell growth and tumorigenesis; nonetheless, de novo or acquired resistance to therapy often lead to patient relapse and disease progression. There is cumulating evidence supporting the importance of tumor microenvironment (TME)-driven mechanisms in cancer progression and drug resistance. Therefore, there is a need for cancer models in which crit

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