Academic literature on the topic 'Cancer-On-Chip'

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Journal articles on the topic "Cancer-On-Chip"

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Torisawa, Yu-suke, Yuta Mishima, and Shin Kaneko. "Developing thymus-on-a-chip and cancer-on-a-chip for cancer immunotherapy." Impact 2019, no. 2 (2019): 33–35. http://dx.doi.org/10.21820/23987073.2019.2.33.

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Zhang, Xiaojun, Mazharul Karim, Md Mahedi Hasan, et al. "Cancer-on-a-Chip: Models for Studying Metastasis." Cancers 14, no. 3 (2022): 648. http://dx.doi.org/10.3390/cancers14030648.

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The microfluidic-based cancer-on-a-chip models work as a powerful tool to study the tumor microenvironment and its role in metastasis. The models recapitulate and systematically simplify the in vitro tumor microenvironment. This enables the study of a metastatic process in unprecedented detail. This review examines the development of cancer-on-a-chip microfluidic platforms at the invasion/intravasation, extravasation, and angiogenesis steps over the last three years. The on-chip modeling of mechanical cues involved in the metastasis cascade are also discussed. Finally, the popular design of mi
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Komen, Job, Sanne M. van Neerven, Elsbeth G. B. M. Bossink, et al. "The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts." Micromachines 13, no. 5 (2022): 739. http://dx.doi.org/10.3390/mi13050739.

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The cancer xenograft model in which human cancer cells are implanted in a mouse is one of the most used preclinical models to test the efficacy of novel cancer drugs. However, the model is imperfect; animal models are ethically burdened, and the imperfect efficacy predictions contribute to high clinical attrition of novel drugs. If microfluidic cancer-on-chip models could recapitulate key elements of the xenograft model, then these models could substitute the xenograft model and subsequently surpass the xenograft model by reducing variation, increasing sensitivity and scale, and adding human f
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Lin, Tianxiu. "Organ-on-a-Chip Models for Pancreatic Cancer Research." International Journal of Sciences Volume 9, no. 2020-02 (2020): 49–56. https://doi.org/10.5281/zenodo.3980037.

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Pancreatic cancer is the one of lowest survival rate cancer among all kinds of cancer. This is because its early syndromes are very different from other fatal diseases. Although with the development of the detection and management, more than 96% of the patients cannot live more than 5 years after diagnosis. Survival rate is low for those with malignant disease in the pancreas, because surgical resection at present may cut off the only chance of the cure. Unfortunately, 80–85% of patients are present with advanced unresectable pathology. Furthermore, pancreatic cancer responds poorly to most ch
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Lee, I.-Chi. "Cancer-on-a-chip for Drug Screening." Current Pharmaceutical Design 24, no. 45 (2019): 5407–18. http://dx.doi.org/10.2174/1381612825666190206235233.

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: The oncology pharmaceutical research spent a shocking amount of money on target validation and drug optimization in preclinical models because many oncology drugs fail during clinical trial phase III. One of the most important reasons for oncology drug failures in clinical trials may due to the poor predictive tool of existing preclinical models. Therefore, in cancer research and personalized medicine field, it is critical to improve the effectiveness of preclinical predictions of the drug response of patients to therapies and to reduce costly failures in clinical trials. Three dimensional (
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Hao, Hsu-Chao, and Da-Jeng Yao. "Detection of Cancer Cells on a Chip." Current Topics in Medicinal Chemistry 15, no. 15 (2015): 1543–50. http://dx.doi.org/10.2174/1568026615666150414150950.

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Elmusrati, Mohammed, and Nureddin Ashammakhi. "Cancer-on-a-Chip and Artificial Intelligence." Journal of Craniofacial Surgery 29, no. 7 (2018): 1682–83. http://dx.doi.org/10.1097/scs.0000000000004703.

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Reed, Sarah C., Chad Potts, P. Brent Ferrell, and Ben H. Park. "Abstract 1210: Modeling clonal hematopoiesis of indeterminate potential (CHIP) in solid tumors: genotype-specific effects on tumor growth and immune microenvironment." Cancer Research 85, no. 8_Supplement_1 (2025): 1210. https://doi.org/10.1158/1538-7445.am2025-1210.

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Abstract Clonal Hematopoiesis of Indeterminate Potential (CHIP) is characterized by expanded blood cell clones containing somatic mutations in leukemia-associated genes in patients without hematologic malignancies. CHIP incidence increases with age, and it is primarily associated with an increased risk of transformation to myeloid neoplasms and cardiovascular disease. Growing evidence indicates that CHIP is associated with aberrant inflammatory signaling, and retrospective analyses have revealed increased risk or poor outcomes in a wide range of diseases. We hypothesized that CHIP alters the i
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Zuchowska, Agnieszka, and Sandra Skorupska. "Multi-organ-on-chip approach in cancer research." Organs-on-a-Chip 4 (December 2022): 100014. http://dx.doi.org/10.1016/j.ooc.2021.100014.

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Fey, M. F. "The impact of chip technology on cancer medicine." Annals of Oncology 13 (October 2002): 109–13. http://dx.doi.org/10.1093/annonc/mdf647.

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Dissertations / Theses on the topic "Cancer-On-Chip"

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Chatagnon, Amandine. "Spécificité de liaison et de répression de la " Methyl-CpG-Binding Domain protein 2 " (MBD2) : identification de gènes cibles impliqués dans les cancers." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00603777.

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De nombreux gènes suppresseurs de tumeurs sont inactivés par hyperméthylation dans les cancers. Cette inactivation serait en partie initiée par la protéine, MBD2 (Methyl-CpG-Binding Domain protein 2). Cette protéine recrute au niveau de séquences méthylées des complexes enzymatiques capables de modifier la structure chromatinienne et crée ainsi des régions fonctionnellement inactives. Dès lors, ce répresseur apparaît être une cible potentielle pour combattre le cancer. Dans cette perspective, rechercher les cibles de MBD2 et comprendre sa capacité à contrôler l'expression génique semblent cruc
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Maassarani, Mahmoud El. "Identification de gènes cibles d'ErbB380kDa et caractérisation de leur implication au cours de la progression du cancer de la prostate." Thesis, Poitiers, 2014. http://www.theses.fr/2014POIT2275/document.

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Pour croître et proliférer, les cellules cancéreuses de la prostate activent des voies de signalisation dépendantes des androgènes. L'intervention thérapeutique en première ligne du cancer de la prostate (CaP) s'appuie donc d’abord sur le blocage de l'axe androgènes-récepteur aux androgènes (RA) mais rapidement, les patients développent des tumeurs résistantes (CRPC, Castration Resistant Prostate Cancer).Les récepteurs à activité tyrosine kinase de la famille ErbB semblent jouer un rôle dans cette résistance, en particulier le récepteur ErbB3. En effet, l'inactivation des voies en aval d'ErbB1
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Alexander, Frank. "RTEMIS: Real-Time Tumoroid and Environment Monitoring Using Impedance Spectroscopy and pH Sensing." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5168.

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This research utilizes Electrical Impedance Spectroscopy, a technique classically used for electrochemical analysis and material characterization, as the basis for a non-destructive, label-free assay platform for three dimensional (3D) cellular spheroids. In this work, a linear array of microelectrodes is optimized to rapidly respond to changes located within a 3D multicellular model. In addition, this technique is coupled with an on chip micro-pH sensor for monitoring the environment around the cells. Finally, the responses of both impedance and pH are correlated with physical changes within
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Han, Arum. "Microfabricated Multi-Analysis System for Electrophysiological Studies of Single Cells." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/11639.

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A micro-electrophysiological analysis system (-EPAS) using various microfabrication techniques for single cell study was developed. Conventional microfabrication techniques combined with plastic and polymer microfabrication techniques have been used to realize the system. The system is capable of performing patch clamp recording and whole cell electrical impedance spectroscopy (EIS) on a single cell. Methodologies for single cell manipulation were developed. The ion channel activities of primary cultured bovine chromaffin cells were measured in both the patch clamping mode and the whole ce
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Veith, Irina. "Lung Cancer On-Chip for Immunotherapy Response Profiling Apoptosis Mapping in Space and Time of 3D Tumor Ecosystems Reveals Transmissibility of Cytotoxic Cancer Death." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL036.

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Le cancer du poumon non à petites cellules (CPNPC) est l'une des rares maladies tumorales, avec mélanome et carcinome vésical, pour lesquelles les médicaments immuno-oncologiques ont conduit à une révolution thérapeutique. Seuls 20 à 30% des patients atteints de CPNPC bénéficient de la monothérapie avec inhibiteurs des points de contrôle immunitaires (ICP) avec des réponses durables, tandis que les combinaisons ont conduit à réponse longue dans jusqu'à 40% des patients. Notre étude vise à mieux caractériser la modulation du microenvironnement tumoral lors d'un traitement ICP, plus ou moins une
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Browne, Andrew W. "Translational Lab-on-a-Chips with the Development of a Novel Cancer Screening Method." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275659036.

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Salmanzadehdozdabi, Alireza. "Microfluidic differentiation of subpopulations of cells based on their bioelectrical signature." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/19370.

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Applications for lab-on-a-chip devices have been expanding rapidly in the last decade due to their lower required volume of sample, faster experiments, smaller tools, more control, and ease of parallelization compared to their macroscale counterparts. Moreover, lab-on-a-chip devices provide important capabilities, including isolating rare cells from body fluids, such as isolating circulating tumor cells from blood or peritoneal fluid, which are not feasible or at least extremely difficult with macroscale devices. Particles experience different forces (and/or torques) when they are suspended in
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Saint-Auret, Gaëlle. "Identification de la signature moléculaire de C/EBPβ dans la cellule d'hépatome humain Hep3B". Rouen, 2008. http://www.theses.fr/2008ROUES057.

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Le foie joue un rôle essentiel dans les régulations métaboliques complexes qui participent largement à l'homéostasie de l'organisme. De plus, cet organe orchestre les changements qualitatifs et quantitatifs intervenant dans la production de protéines de défense immédiatement nécessaires à la réponse à un syndrome inflammatoire aigü systémique et au retour progressif à l'homéostasie qui s'ensuit. Le facteur de transcription CCAAT enhancer-binding protein beta (C/EBPβ) enrichi dans le foie est très impliqué dans tous ces processus. Toutefois, il existe de nombreuses incohérences quant au rôle pr
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Ahmad-Cognart, Hamizah. "Study of the Metastatic Process of Circulating Tumour Cells by Organ-on-a-Chip In Vitro Models." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC139/document.

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90% de la mortalité par cancer provient de tumeurs disséminées, ou métastases. Ces métastases se forment à partir de cellules tumorales qui s'échappent d'une tumeur primaire, circulent dans le sang, puis quittent les vaisseaux sanguins pour enfin aller nicher dans des organes distants et former des tumeurs secondaires. Les processus par lesquels ces cellules circulantes envahissent les organes distants, remodèlent leur environnement pour créer une «niche micrométastatique», prolifèrent pour produire des métastases macroscopiques, sont mal connus, principalement en raison d'un manque de modèles
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Godier, Claire. "Développement de cancer sur puce : application au cancer du pancréas." Electronic Thesis or Diss., Université de Lorraine, 2024. http://www.theses.fr/2024LORR0164.

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L'adénocarcinome canalaire pancréatique (PDAC) est considéré comme l'une des formes les plus agressives du cancer du pancréas. En raison des limites des modèles précliniques traditionnels pour simuler la complexité du microenvironnement tumoral, un taux d'échec supérieur à 90 % est observé pour les nouvelles molécules thérapeutiques. Pour pallier cette insuffisance, l'enrichissement des modèles précliniques par l'ajout d'une troisième dimension est devenu nécessaire. Bien que les modèles tels que les sphéroïdes et organoïdes aient été introduits, leur reproductibilité et leur coût demeurent pr
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Books on the topic "Cancer-On-Chip"

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Nanobiosensors for Personalized and Onsite Biomedical Diagnosis. Institution of Engineering & Technology, 2016.

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Book chapters on the topic "Cancer-On-Chip"

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Tong, Ziqiu, Wing-Yin Tong, Bo Peng, Yingkai Wei, Arianna Oddo, and Nicolas H. Voelcker. "Using Integrated Cancer-on-Chip Platforms to Emulate and Probe Various Cancer Models." In Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-59596-1_4.

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Caballero, David, Rui L. Reis, and Subhas C. Kundu. "Engineering Patient-on-a-Chip Models for Personalized Cancer Medicine." In Advances in Experimental Medicine and Biology. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-36588-2_4.

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Bretti, Gabriella, Elio Campanile, Marta Menci, and Roberto Natalini. "A Scenario-Based Study on Hybrid PDE-ODE Model for Cancer-on-Chip Experiment." In SEMA SIMAI Springer Series. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-60773-8_3.

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Ho-Pun-Cheung, Alexandre, Hafid Abaibou, Philippe Cleuziat, and Evelyne Lopez-Crapez. "Detection of Single-Nucleotide Polymorphisms in Cancer-Related Genes by Minisequencing on a Microelectronic DNA Chip." In Microarrays. Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-303-5_13.

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Yang, Yamin, and Hongjun Wang. "Microfluidic Technologies for Head and Neck Cancer: From Single-Cell Analysis to Tumor-on-a-Chip." In Early Detection and Treatment of Head & Neck Cancers. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-69859-1_3.

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Parihar, Arpana, Nishant Kumar Choudhary, Dipesh Singh Parihar, and Raju Khan. "Tumor-on-a-Chip: Microfluidic Models of Hypoxic Tumor Microenvironment." In Hypoxia in Cancer: Significance and Impact on Cancer Therapy. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-0313-9_14.

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Lopez-Muñoz, Gerardo A., Sheeza Mughal, and Javier Ramón-Azcón. "Correction to: Sensors and Biosensors in Organs-on-a-Chip Platforms." In Microfluidics and Biosensors in Cancer Research. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-04039-9_23.

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Li, Caiwei, Jiao Zhai, and Yanwei Jia. "Digital Microfluidics with an On-Chip Drug Dispenser for Single or Combinational Drug Screening." In Microfluidic Systems for Cancer Diagnosis. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-3271-0_3.

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Elnour, Ahmed A. M., Nureddin Ashammakhi, and El Bashier Sallam. "Opportunities for Investing in Organ-on-a-Chip (OoC) Technology, Breast-on-a-Chip (BoC) as an Example Technology Transfer into Islamic Development Bank Members Countries (IsDB-MCs)." In Gum Arabic and Breast Cancer Biology. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-8518-6_7.

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Elnour, Ahmed A. M., Abdurahmani Hamid Nour, and Nureddin Ashammakhi. "Breast-on-a-Chip Technology Application Using Acacia Gums (AGs) Secondary Metabolites Extract (SME)." In Gum Arabic and Breast Cancer Biology. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-8518-6_10.

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Conference papers on the topic "Cancer-On-Chip"

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Khoubafarin, Somaiyeh, Cyrus Koogan, and Aniruddha Ray. "High-Resolution On-Chip Fluorescence Microscopy for Rapid Screening of Chemotherapeutic Drugs." In Novel Techniques in Microscopy. Optica Publishing Group, 2025. https://doi.org/10.1364/ntm.2025.nw1c.4.

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We developed a cost-effective high-resolution on-chip fluorescence microscope with a wide field-of-view, enabling the imaging of several hundred cells simultaneously. This microscope was used to study drug-induced oxidative stress and cell death in cancer cells.
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Beykou, Melina, Costanza Gulli, Vicky Bousgouni, Nicolas Moser, Chris Bakal, and Pantelis Georgiou. "Dynamic pH fluctuations in cancer cells on CMOS-based Lab-on-Chip ISFET arrays." In 2024 IEEE Biomedical Circuits and Systems Conference (BioCAS). IEEE, 2024. https://doi.org/10.1109/biocas61083.2024.10798162.

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Sima, Felix, Kotaro Obata, Mirai Hanzawa, et al. "Ultrafast laser processing of transparent materials for testing cancer cell behavior in tumor-on-chip models." In Laser-based Micro- and Nanoprocessing XIX, edited by Rainer Kling, Wilhelm Pfleging, and Koji Sugioka. SPIE, 2025. https://doi.org/10.1117/12.3041206.

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Lin, Ching-Yi, Yann Gilpin, Zixin Chen, Elizabeth Wayne, and Marc Dandin. "Towards a Lab-on-a-Chip as a Service (LoCaaS) Framework for in Vitro Cancer Cell Assays." In 2024 22nd IEEE Interregional NEWCAS Conference (NEWCAS). IEEE, 2024. http://dx.doi.org/10.1109/newcas58973.2024.10666355.

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Yapeter, Calista Adele, Katerina-Theresa Mantikas, Costanza Gulli, et al. "Electrochemical Sensing of the Colorectal Cancer BRAF p.V600E Mutation Using a Lab-on-Chip Integrated DNA Amplification Analysis Method." In 2024 IEEE SENSORS. IEEE, 2024. https://doi.org/10.1109/sensors60989.2024.10784606.

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Singh, Jagbir, Priyankkumar Patel, Balaji Shesharao Ingole, et al. "Advanced Computational Methods for Pelvic Bone Cancer Detection: Efficacy comparison of Convolutional Neural Networks." In 2024 IEEE 17th International Symposium on Embedded Multicore/Many-core Systems-on-Chip (MCSoC). IEEE, 2024. https://doi.org/10.1109/mcsoc64144.2024.00055.

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Zolala, Hengameh, Fahimeh Gholamshahi, and Maryam Saadatmand. "Improving U-shaped traps in a microfluidic chip to trap cancer cells to form spheroids using simulation." In 2024 31st National and 9th International Iranian Conference on Biomedical Engineering (ICBME). IEEE, 2024. https://doi.org/10.1109/icbme64381.2024.10895316.

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Liao, Han-Jung, Jean-An Chieh, Yu-Chen Chen, et al. "Lung Cancer On Chip for Testing Immunotherapy." In 2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers). IEEE, 2021. http://dx.doi.org/10.1109/transducers50396.2021.9495530.

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Chang, Kuo-Wei, Tushar Harishchandra Punde, Gaurav Prashant Pendharkar, et al. "Lung cancer model on chip for drug testing." In TRANSDUCERS 2015 - 2015 18th International Solid-State Sensors, Actuators and Microsystems Conference. IEEE, 2015. http://dx.doi.org/10.1109/transducers.2015.7181006.

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Darabi, Jeff, and Joseph Schober. "A Microfluidic Platform for On-Chip Analysis of Circulating Tumor Cells." In ASME 2021 Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2021. http://dx.doi.org/10.1115/fedsm2021-65766.

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Abstract Studies have shown that primary tumor sites begin shedding cancerous cells into peripheral blood at early stages of cancer, and the presence and frequency of circulating tumor cells (CTCs) in blood is directly proportional to disease progression. The challenge is that the concentration of the CTCs in peripheral blood may be extremely low. In the past few years, several microfluidic-based concepts have been investigated to isolate CTCs from whole blood. However, these devices are generally hampered by complex fabrication processes and very low volumetric throughputs, which may not be p
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