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Dissertations / Theses on the topic 'Cancer-On-Chip'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Chatagnon, Amandine. "Spécificité de liaison et de répression de la " Methyl-CpG-Binding Domain protein 2 " (MBD2) : identification de gènes cibles impliqués dans les cancers." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00603777.

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De nombreux gènes suppresseurs de tumeurs sont inactivés par hyperméthylation dans les cancers. Cette inactivation serait en partie initiée par la protéine, MBD2 (Methyl-CpG-Binding Domain protein 2). Cette protéine recrute au niveau de séquences méthylées des complexes enzymatiques capables de modifier la structure chromatinienne et crée ainsi des régions fonctionnellement inactives. Dès lors, ce répresseur apparaît être une cible potentielle pour combattre le cancer. Dans cette perspective, rechercher les cibles de MBD2 et comprendre sa capacité à contrôler l'expression génique semblent cruc

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2

Maassarani, Mahmoud El. "Identification de gènes cibles d'ErbB380kDa et caractérisation de leur implication au cours de la progression du cancer de la prostate." Thesis, Poitiers, 2014. http://www.theses.fr/2014POIT2275/document.

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Pour croître et proliférer, les cellules cancéreuses de la prostate activent des voies de signalisation dépendantes des androgènes. L'intervention thérapeutique en première ligne du cancer de la prostate (CaP) s'appuie donc d’abord sur le blocage de l'axe androgènes-récepteur aux androgènes (RA) mais rapidement, les patients développent des tumeurs résistantes (CRPC, Castration Resistant Prostate Cancer).Les récepteurs à activité tyrosine kinase de la famille ErbB semblent jouer un rôle dans cette résistance, en particulier le récepteur ErbB3. En effet, l'inactivation des voies en aval d'ErbB1

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3

Alexander, Frank. "RTEMIS: Real-Time Tumoroid and Environment Monitoring Using Impedance Spectroscopy and pH Sensing." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5168.

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This research utilizes Electrical Impedance Spectroscopy, a technique classically used for electrochemical analysis and material characterization, as the basis for a non-destructive, label-free assay platform for three dimensional (3D) cellular spheroids. In this work, a linear array of microelectrodes is optimized to rapidly respond to changes located within a 3D multicellular model. In addition, this technique is coupled with an on chip micro-pH sensor for monitoring the environment around the cells. Finally, the responses of both impedance and pH are correlated with physical changes within

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4

Han, Arum. "Microfabricated Multi-Analysis System for Electrophysiological Studies of Single Cells." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/11639.

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A micro-electrophysiological analysis system (-EPAS) using various microfabrication techniques for single cell study was developed. Conventional microfabrication techniques combined with plastic and polymer microfabrication techniques have been used to realize the system. The system is capable of performing patch clamp recording and whole cell electrical impedance spectroscopy (EIS) on a single cell. Methodologies for single cell manipulation were developed. The ion channel activities of primary cultured bovine chromaffin cells were measured in both the patch clamping mode and the whole ce

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5

Veith, Irina. "Lung Cancer On-Chip for Immunotherapy Response Profiling Apoptosis Mapping in Space and Time of 3D Tumor Ecosystems Reveals Transmissibility of Cytotoxic Cancer Death." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL036.

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Le cancer du poumon non à petites cellules (CPNPC) est l'une des rares maladies tumorales, avec mélanome et carcinome vésical, pour lesquelles les médicaments immuno-oncologiques ont conduit à une révolution thérapeutique. Seuls 20 à 30% des patients atteints de CPNPC bénéficient de la monothérapie avec inhibiteurs des points de contrôle immunitaires (ICP) avec des réponses durables, tandis que les combinaisons ont conduit à réponse longue dans jusqu'à 40% des patients. Notre étude vise à mieux caractériser la modulation du microenvironnement tumoral lors d'un traitement ICP, plus ou moins une

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6

Browne, Andrew W. "Translational Lab-on-a-Chips with the Development of a Novel Cancer Screening Method." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1275659036.

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7

Salmanzadehdozdabi, Alireza. "Microfluidic differentiation of subpopulations of cells based on their bioelectrical signature." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/19370.

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Applications for lab-on-a-chip devices have been expanding rapidly in the last decade due to their lower required volume of sample, faster experiments, smaller tools, more control, and ease of parallelization compared to their macroscale counterparts. Moreover, lab-on-a-chip devices provide important capabilities, including isolating rare cells from body fluids, such as isolating circulating tumor cells from blood or peritoneal fluid, which are not feasible or at least extremely difficult with macroscale devices. Particles experience different forces (and/or torques) when they are suspended in

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8

Saint-Auret, Gaëlle. "Identification de la signature moléculaire de C/EBPβ dans la cellule d'hépatome humain Hep3B". Rouen, 2008. http://www.theses.fr/2008ROUES057.

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Le foie joue un rôle essentiel dans les régulations métaboliques complexes qui participent largement à l'homéostasie de l'organisme. De plus, cet organe orchestre les changements qualitatifs et quantitatifs intervenant dans la production de protéines de défense immédiatement nécessaires à la réponse à un syndrome inflammatoire aigü systémique et au retour progressif à l'homéostasie qui s'ensuit. Le facteur de transcription CCAAT enhancer-binding protein beta (C/EBPβ) enrichi dans le foie est très impliqué dans tous ces processus. Toutefois, il existe de nombreuses incohérences quant au rôle pr

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9

Ahmad-Cognart, Hamizah. "Study of the Metastatic Process of Circulating Tumour Cells by Organ-on-a-Chip In Vitro Models." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC139/document.

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90% de la mortalité par cancer provient de tumeurs disséminées, ou métastases. Ces métastases se forment à partir de cellules tumorales qui s'échappent d'une tumeur primaire, circulent dans le sang, puis quittent les vaisseaux sanguins pour enfin aller nicher dans des organes distants et former des tumeurs secondaires. Les processus par lesquels ces cellules circulantes envahissent les organes distants, remodèlent leur environnement pour créer une «niche micrométastatique», prolifèrent pour produire des métastases macroscopiques, sont mal connus, principalement en raison d'un manque de modèles

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10

Godier, Claire. "Développement de cancer sur puce : application au cancer du pancréas." Electronic Thesis or Diss., Université de Lorraine, 2024. http://www.theses.fr/2024LORR0164.

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L'adénocarcinome canalaire pancréatique (PDAC) est considéré comme l'une des formes les plus agressives du cancer du pancréas. En raison des limites des modèles précliniques traditionnels pour simuler la complexité du microenvironnement tumoral, un taux d'échec supérieur à 90 % est observé pour les nouvelles molécules thérapeutiques. Pour pallier cette insuffisance, l'enrichissement des modèles précliniques par l'ajout d'une troisième dimension est devenu nécessaire. Bien que les modèles tels que les sphéroïdes et organoïdes aient été introduits, leur reproductibilité et leur coût demeurent pr

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11

Baka, Zakaria. "Élaboration de cancers sur puce pour des applications en thérapies anticancéreuses." Electronic Thesis or Diss., Université de Lorraine, 2023. http://www.theses.fr/2023LORR0175.

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Le cancer de l’ovaire constitue un véritable enjeu de santé public. Les nouveaux traitements se heurtent par ailleurs à des taux d’échec très élevés. Ceci s’explique notamment pour le manque de fiabilité des modèles précliniques classiques tels que la culture cellulaire en 2D. De nouveaux outils basés sur la culture cellulaire en 3D ont alors fait leur apparition tels que les sphéroïdes et les organoïdes. Or ces modèles ont leurs propres limites (coûts, difficultés d’application). La bio-impression 3D est une nouvelle approche permettant de créer des modèles tumoraux de manière contrôlée et re

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12

Miollis, Frédérick de. "Développement d’un système de culture in vitro 3D et microfluidique pour étudier les interactions tumeur-stroma et la résistance aux drogues de l’adénocarcinome du pancréas." Thesis, Lille, 2021. http://www.theses.fr/2021LILUI015.

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Le cancer du pancréas est l’un des cancers les plus mortels avec un pronostic extrêmement sombre. En 2020, le taux de survie à 5 ans reste très faible (de 3 à 9 % seulement) et la médiane de survie est de moins de 6 mois. Malgré des progrès dans la prise en charge des patients, les thérapies actuelles n’ont pas l’efficacité espérée. Ceci est dû à la forte chimiorésistance observée dans ce cancer. Le facteur clé de cette résistance est le microenvironnement tumoral complexe composé majoritairement de stroma et d’une matrice extracellulaire dense limitant l’accès des thérapies à la tumeur. Les l

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13

Bourg, Samantha. "Développement de systèmes miniaturisés à base d’aptamères pour la détection de biomarqueurs de cancer." Thesis, Paris Sciences et Lettres (ComUE), 2019. http://www.theses.fr/2019PSLEC020.

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Les méthodes habituelles de diagnostic du cancer sont invasives et coûteuses et permettent rarement de dépister la maladie à un stade précoce. L'apparition de biomarqueurs de cancer a été mise en évidence à un stade précoce de la maladie, bien avant le développement des symptômes. Ces marqueurs sont encore peu utilisés, notamment du fait de leur présence en faible quantité chez des individus sains, mais aussi de leur manque de spécificité pris individuellement. De nos jours, les analyses cliniques pour le diagnostic ou le suivi de certains paramètres sont effectués par division des prélèvement

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14

Shah, Pranjul, Joëlle V. Fritz, Enrico Glaab, et al. "A microfluidics-based in vitro model of the gastrointestinal human–microbe interface." NATURE PUBLISHING GROUP, 2016. http://hdl.handle.net/10150/614760.

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Changes in the human gastrointestinal microbiome are associated with several diseases. To infer causality, experiments in representative models are essential, but widely used animal models exhibit limitations. Here we present a modular, microfluidics-based model (HuMiX, human-microbial crosstalk), which allows co-culture of human and microbial cells under conditions representative of the gastrointestinal human-microbe interface. We demonstrate the ability of HuMiX to recapitulate in vivo transcriptional, metabolic and immunological responses in human intestinal epithelial cells following their

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15

Carvalho, Mariana Rodrigues de. "Tissue engineered in vitro models on a chip for cancer research." Doctoral thesis, 2019. http://hdl.handle.net/1822/64605.

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Tese de Doutoramento em Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais<br>By 2030, the global burden is expected to grow to 21.7 million new cancer cases and 13 million cancer deaths simply due to the growth and aging of the population. Among all types of cancer, colorectal cancer is a major cause of morbidity and mortality worldwide, and accounts for over 9 % of all cancer incidence. It is the third most common cancer worldwide and affects men and women equally. In order to win the battle against cancer, further advances are in great need to unveil identification of ca

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16

Sultana, Ruksar. "Lab-on-a-chip tissue engineered 3D cancer model for in-vitro anti-cancer drug screening." Thesis, 2014. http://ethesis.nitrkl.ac.in/6401/1/E-2.pdf.

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Development of in-vitro 3D cellular disease models is emerging at a fast pace. 2D culture systems are limited due to minimal cell-cell interactions and poor stromal intervention. Hence, there is a need to develop 3D models which are more physiologically relevant than 2D models & improves the prediction of drug candidates. 3D models possess more realistic multicellular complexity (cell-cell, cell-matrix interactions) and mimics in-vitro microenvironment more closely. Present study delineates the development of a novel in-vitro 3D cancer model by incorporating cancer aggregates into porous scaff

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17

Raamanathan, Archana. "Programmable bio-nano-chip immunosensor for multiplexed detection of ovarian cancer biomarkers." 2011. http://hdl.handle.net/2152/20658.

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Ovarian cancer is a high mortality disease where early stage detection may have significant survival benefits. Promising next-generation non-invasive, biomarker-based screening modalities involve longitudinal monitoring of serum biomarkers and multi-marker panel detection. Here, rapid, sensitive, precise and multiplexable diagnostic platforms can facilitate biomarker validation along with early detection and screening, and this work attempts to exploit the programmable bio-nano-chip (p-BNC) immunosensor to address these specific translational needs in ovarian cancer. First, the p-BNC was adapt

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18

Goldvasser, Pavel. "Identification of Novel Notch Target Genes in Breast Cancer." Thesis, 2011. http://hdl.handle.net/1807/30607.

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Notch signaling plays a key role in development, tissue homeostasis, and cancer. High expression levels of Notch signaling components are associated with aggressive disease and poor patient prognosis in breast cancer. Mesenchymal‐epithelial transition factor (MET) is a receptor tyrosine kinase with an established prognostic significance correlating with poor disease outcome in breast cancer patients as a result of high metastatic rate. We performed expression array analysis to identify candidate Notch target genes; we identified and validated MET as a target of NOTCH1 signaling in breast cance

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19

Jokerst, Jesse Vincent. "Next generation transduction pathways for nano-bio-chip array platforms." Thesis, 2009. http://hdl.handle.net/2152/26880.

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In the following work, nanoparticle quantum dot (QD) fluorophores have been exploited to measure biologically relevant analytes via a miniaturized sensor ensemble to provide key diagnostic and prognostic information in a rapid, yet sensitive manner—data essential for effective treatment of many diseases including HIV/AIDS and cancer. At the heart of this “nano-bio-chip” (NBC) sensor is a modular chemical/cellular processing unit consisting of either a polycarbonate membrane filter for cell-based assays, or an agarose bead array for detection of biomarkers in serum or saliva. Two applications o

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20

Weigum, Shannon Elise. "Development of a cell-based lab-on-a-chip sensor for detection of oral cancer biomarkers." 2008. http://hdl.handle.net/2152/9817.

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Oral cancer is the sixth most common cancer worldwide and has been marked by high morbidity and poor survival rates that have changed little over the past few decades. Beyond prevention, early detection is the most crucial determinant for successful treatment and survival of cancer. Yet current methodologies for cancer diagnosis based upon pathological examination alone are insufficient for detecting early tumor progression and molecular transformation. Development of new diagnostic tools incorporating tumor biomarkers could enhance early detection by providing molecular-level insight into the

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21

Tsao, Chia-Ling, and 曹嘉玲. "Using on-chip cytokine immunofluorescence assay (CIFA) to study lung cancer cell responses to external stimulations." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/sm74us.

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22

Hsieh, Hui-Hsia, and 謝蕙霞. "A Gene Chip Approach to Anti-cancer Effect of Tien-Shen Lingzhi Ethanol Extracts on Non-Small Cell Lung Cancer Cell Line." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/31056900584822048788.

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碩士<br>亞洲大學<br>生物資訊學系碩士班<br>98<br>Background: Lung cancers are among the neoplastic diseases with the worst prognosis. More treatment modalities are needed to improve clinical outcome. It’s being a new trend to search for bioactive traditional Chinese medicines (TCM). Ganoderma, also known as Lingzhi, is a TCM and has been widely used for improving human health for centuries. We have addressed the anticancer effects of Ganoderma on various cancers. In this study, a comprehensive genomic profiling was used to further explore the signal pathway for the anticancer effects of Tien Shen Lingzhi(TSL)

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23

Lu, Chung-Huan, and 呂仲桓. "The on-chip high- efficient electrofusion of dendritic cells and tumor cells for efficient cancer vaccine generation." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/r7vqda.

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碩士<br>國立清華大學<br>動力機械工程學系<br>102<br>Because people lifestyle changed, cancer has been the top ten causes of death for 13 years. In every 100 people, 28 people were dead because of cancer. Cancer is caused by either the congenital mutations or the overexpression of oncogenes. It has a powerful ability to transform proliferative and transfer. Because the activation of oncogenes mutations takes months, the diagnosis need a long time. Therefore, the cancer was considered a terminal illness. However, with the medical improvement, the surgery and chemotherapy have been used to cure malignant tumors.

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24

Lin, Wei-Liang, and 林威良. "Suppression of myofibroblast-induced cancer cell migration by macrophages: studies on a multi-chamber cell culture chip." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/89071614835484923035.

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碩士<br>國立陽明大學<br>生醫光電工程研究所<br>99<br>In the tumor microenvironment, a lot of stromal cells secret growth factors to enhance the metastasis, proliferation, and survival of cancer cells. A number of cells including fibroblasts and macrophages are involved in the metastasis of a primary tumour. We develop microfluidic cell culture chips that contain three culture chambers to co-culture lung cancer cells, macrophages, and fibroblasts to study the interactions amount them. The results showed that cancer cells were activated fibroblasts into myofibroblasts by conditional medium of cancer cell. The myo

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25

Kao, Feng-Sheng, and 高豐生. "Chip-based protein-protein interaction force measurement and cancer drug effect on cell’s Young’s modulus by atomic force microscopy." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/54530650874466921725.

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博士<br>國立交通大學<br>機械工程系所<br>101<br>In this dissertation, we demonstrated that the direct and accurate measurement of protein-protein interaction force can be done by atomic force microscopy (AFM) via immobilization of one protein on chip (imm-protein) and another on probe tip of AFM (afm-protein). Preliminarily, we observed the binding between T-cell receptor, CD28 (imm-CD28), and B-cell receptor, CD80 (afm-CD80), with an immuno-suppressive blocker, cynarin. Average unbinding forces were reduced from 61.4 pN to 38.9 pN with a blocking effect of ~37% as compared with ~9% by SPR. Using AFM as a de

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Oliveira, Ana Beatriz Brito de. "A novel approach for chip-based digital LAMP towards the quantification of prostate cancer biomarkers." Master's thesis, 2019. http://hdl.handle.net/10362/88336.

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Nucleic acids amplification-based methods can profit from the features offered by Lab-on-a-chip technologies, in particular those that aimed for molecular diagnosis purposes. Currently, isothermal amplification approaches, more precisely LAMP, have become promising alternatives to the current gold standard technology (PCR). Regardless the amplification mechanism, accurate target quantification is still challenging. To this end, the development of digital amplification methods has helped to circumvent this limitation. This thesis focused on the development of a chip-based digital LAMP system

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27

SEPE, ELISABETTA. "Cancer biomarkers detection in cell lysates by means of anisotropic fluorescence at the surface of 1D photonic crystal biochips." Doctoral thesis, 2020. http://hdl.handle.net/11573/1362079.

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Novel disposable optical biochips based on one-dimensional photonic crystals (1DPC) sustaining Bloch surface waves (BSW) are an attractive tool for the detection of several disease-related biomarkers. In response to growing global burden of cancer, one of the most significant public health challenges of the 21st century is the prevention and early diagnosis of this disease. By diagnosing in advance such disease permits to increase the survival probability of patients and to improve their life perspectives. Consequently, cancer biomarkers have gained considerable attention. Within this framewor

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28

Ferreira, Daniel André Gonçalves. "A tissue engineering approach to fabricate a stomach-on-a-chip: a biomimetic device to decode the role of CD44v6 in gastric cancer." Doctoral thesis, 2021. https://hdl.handle.net/10216/138576.

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Pilarski, Patrick Michael. "Computational analysis of wide-angle light scattering from single cells." Phd thesis, 2009. http://hdl.handle.net/10048/774.

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Thesis (Ph.D.)--University of Alberta, 2009.<br>Title from PDF file main screen (viewed on Apr. 1, 2010). A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Doctor of Philosophy, Department of Electrical and Computer Engineering, University of Alberta. Includes bibliographical references.

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