Academic literature on the topic 'Cancer, p53, lncRNA, non-coding RNA'

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Journal articles on the topic "Cancer, p53, lncRNA, non-coding RNA"

1

Su, Tong, Bobby Kong, Calvin Huang, Jonathan Zhu, and Colleen McHugh. "Abstract 1533: Long non-coding RNA control of cancer cell growth." Cancer Research 82, no. 12_Supplement (2022): 1533. http://dx.doi.org/10.1158/1538-7445.am2022-1533.

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Abstract Long non-coding RNAs (lncRNAs) are involved in controlling regulatory networks critical for gene expression, cellular growth, and development. Altered expression of lncRNAs are associated with tumor progression in multiple types of human cancers, but the mechanisms by which lncRNAs may control growth and proliferation in cancer cells remain unknown in most cases. Development of interventions targeting non-coding RNA regulation of cell growth would open new avenues for cancer treatment. To identify growth regulatory pathways controlled by non-coding RNAs, we used proteomics and genomic
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2

Cao, Yu, Deliang Cao, and Hongyan Ling. "The novel long non-coding RNA PANCR: A p53 activator and potential breast cancer biomarkers." Journal of Clinical Oncology 35, no. 15_suppl (2017): e23016-e23016. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e23016.

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e23016 Background: Long non-coding RNAs (LncRNAs) may serve as a biomarker and potential therapeutic target of cancers. Chromosome 16q22.1 is frequently deleted in breast cancer and may contribute to breast carcinogenesis by inactivation of tumor suppressor genes. This study characterized a new LncRNA tumor suppressor in this region, named p53 activating non-coding RNA (PANCR). This LncRNA consists of 1.5kb in length. Methods: Quantitative real-time PCR was used for examine the PANCR expression in breast cancer tissues. RNA-pull down and RNA-Immunopreicitation were used to analyze PANCR target
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3

Zhao, Dongyan, Xizhen Sun, Sidan Long, and Shukun Yao. "An autophagy-related long non-coding RNA signature for patients with colorectal cancer." Physiology International 108, no. 2 (2021): 202–20. http://dx.doi.org/10.1556/2060.2021.00125.

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AbstractAimLong non-coding RNAs (lncRNAs) have been identified to regulate cancers by controlling the process of autophagy and by mediating the post-transcriptional and transcriptional regulation of autophagy-related genes. This study aimed to investigate the potential prognostic role of autophagy-associated lncRNAs in colorectal cancer (CRC) patients.MethodsLncRNA expression profiles and the corresponding clinical information of CRC patients were collected from The Cancer Genome Atlas (TCGA) database. Based on the TCGA dataset, autophagy-related lncRNAs were identified by Pearson correlation
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Bareja, Chanchal, Apoorva Uboveja, and Daman Saluja. "Abstract 1560: Elucidating the differential regulation of novel long non coding RNAs and their mechanism of action in p73 dependent manner." Cancer Research 82, no. 12_Supplement (2022): 1560. http://dx.doi.org/10.1158/1538-7445.am2022-1560.

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Abstract INTRODUCTION: The p53 tumor suppressor family is classically activated after DNA damage and plays a central role in cell fate decisions. Although, the p53 family activates many of the same genes in response to DNA damage, p73 plays distinct biological functions in development and metastasis. It is likely that p73 activates a unique transcriptional network which is critical for its anti-metastatic and anti-invasive action. Long non-coding RNAs (lncRNAs) are a class of mRNA-like transcripts longer than 200 nucleotides. They lack protein-coding ability and are believed to be involved in
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5

Wang, Li, Zhenhong Chen, Li An, et al. "Analysis of Long Non-Coding RNA Expression Profiles in Non-Small Cell Lung Cancer." Cellular Physiology and Biochemistry 38, no. 6 (2016): 2389–400. http://dx.doi.org/10.1159/000445591.

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Background/Aims: Long non-coding RNAs (lncRNAs) play an important role in tumorigenesis. However, the role of lncRNA expression in human Non-small cell lung cancer (NSCLC) biology, prognosis and molecular classification remains unknown. Methods: We established the IncRNA profile in NSCLC by re-annotation of microarrays from the Gene expression omnibus database. Quantitative real-time PCR was used to determine expression of LINC00342. Results: 6066 differentially expressed IncRNAs were identified and we found a novel IncRNA, LINC00342 was significantly up-regulated in NSCLC tissues compared wit
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6

Zhou, Yaodong, and Qing Xia. "LncRNA H19 Promotes Lung Adenocarcinoma Progression via Binding to Mutant p53 R175H." Cancers 14, no. 18 (2022): 4486. http://dx.doi.org/10.3390/cancers14184486.

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Background: Accumulating data suggest that long non-coding RNA (lncRNA) H19 and p53are closely related to the prognosis of lung cancer. This study aims to analyze the association and interaction betweenH19 and mutant p53 R175H in lung adenocarcinoma (LAC). Methods: Mutant-type (Mt) p53 R175H was assessed by using RT-PCR in LAC cells and 100 cases of LAC tissue samples for association with H19 expression. Western blot, RNA-pull down, immunoprecipitation-Western blot and animal experiments were used to evaluate the interaction between H19 and mtp53. Results: Mtp53 R175H and H19 were over-express
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7

Toraih, Eman A., Aya El-Wazir, Mohammad H. Hussein, et al. "Expression of long intergenic non-coding RNA, regulator of reprogramming, and its prognostic value in patients with glioblastoma." International Journal of Biological Markers 34, no. 1 (2019): 69–79. http://dx.doi.org/10.1177/1724600818814459.

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Background: Long intergenic non-coding RNA, regulator of reprogramming ( LINC-ROR) is a newly identified cytoplasmic long non-coding RNA (lncRNA), which has been found to be dysregulated in different cancers. The present work aimed to quantify LINC-ROR expression profile and assess the tumor proteins p53 and caspase 3 expressions in glioblastoma tissue specimens compared to non-cancer tissues, and to correlate these expression levels with the available clinicopathological and survival data. Methods: LINC-ROR relative expression in 57 glioblastoma cancer tissues and 10 non-cancer tissues was qu
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8

Chen, Qiongyun, Xiaoqing Huang, Xuan Dong, Jingtong Wu, Fei Teng, and Hongzhi Xu. "Long non-coding RNA ERICH3-AS1 is an unfavorable prognostic factor for gastric cancer." PeerJ 8 (January 28, 2020): e8050. http://dx.doi.org/10.7717/peerj.8050.

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Long non-coding RNAs (lncRNAs) play important roles in gastric cancer (GC), but the mechanism is not fully clear. ERICH3-AS1 (ERICH3 antisense RNA1) is affiliated with the non-coding RNA class which has proven to be involved in the prognostic of GC, but the function of ERICH3-AS1 is still unclear. In this study, we aim to explore the potential function of ERICH3-AS1 in the development of GC and analyze the prognostic role of ERICH3-AS1 in GC. We found that the lncRNA ERICH3-AS1 was significantly up-regulated in GC tissues in the analysis of The Cancer Genome Atlas (TCGA) data; the Kaplan-Meier
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9

Lai, Xiaojia Zuo, Xintong Yang, et al. "PATH-03. FERROPTOSIS-RELATED LONG NON-CODING RNA SIGNATURES PREDICT PROGNOSIS IN PATIENTS WITH GLIOMA." Neuro-Oncology 23, Supplement_6 (2021): vi115. http://dx.doi.org/10.1093/neuonc/noab196.456.

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Abstract Ferroptosis, with iron-dependent and ROS-dependent, is a novel type of cell death in a variety of diseases and some studies confirmed that ferroptosis-related lncRNAs are involved in the occurrence and development of several cancers. However, the ferroptosis-related lncRNA in the role of gliomas is unclear. Here, we constructed a prognostic scoring model of ferroptosis-related lncRNAs in gliomas. Data were downloaded from the Chinese glioma genome atlas (CGGA), the cancer genome atlas, and FerrDb database. In this study, we found 1051 lncRNAs associated with ferroptosis by Spearman's
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10

Pal, Sonali, Manoj Garg, and Amit Kumar Pandey. "Deciphering the Mounting Complexity of the p53 Regulatory Network in Correlation to Long Non-Coding RNAs (lncRNAs) in Ovarian Cancer." Cells 9, no. 3 (2020): 527. http://dx.doi.org/10.3390/cells9030527.

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Amongst the various gynecological malignancies affecting female health globally, ovarian cancer is one of the predominant and lethal among all. The identification and functional characterization of long non-coding RNAs (lncRNAs) are made possible with the advent of RNA-seq and the advancement of computational logarithm in understanding human disease biology. LncRNAs can interact with deoxyribonucleic acid (DNA), ribonucleic acid (RNA), proteins and their combinations. Moreover, lncRNAs regulate orchestra of diverse functions including chromatin organization and transcriptional and post-transcr
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