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Engler, Jennifer [Verfasser]. "Cancer Care and Cancer Patients’ Experiences with Cancer / Jennifer Engler." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1180994191/34.
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OLSSON, MILLA, and CAROLINE ROSELL. "Telemedicine for Lung Cancer Patients." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-136951.
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Den svenska sjukvården står idag för ett antal utmaningar om den skall fortsatt kunna erbjuda god service som vårdgivare och vara attraktiv som arbetsgivare. Bland annat diskuteras frågor som förvärrad platsbrist, läkarbrist samt avstånd till specialistsjukvård. På Karolinska Universitetssjukhuset i Solna ligger Radiumhemmet och där behandlas bland annat lungcancerpatienter. Där diskuteras huruvida telemedicin kan vara en möjlig väg för att lösa ovanstående problem. Denna uppsats utreder på vilket sätt telemedicin kan användas på Radiumhemmet för lungcancerpatienter. För att kunna utreda en telemedicinsk lösnings möjligheter på Radiumhemmet genomfördes intervjuer och fokusgrupper med personalen. Externa experter från sjukvården och industri intervjuades och ett besök gjordes på barnsjukhuset Childrens Healthcare of Atlanta, USA, där man har kommit långt i användningen av telemedicin. Det finns delar av verksamheten på Radiumhemmet där telemedicin skulle kunna bidra till att skapa möjligheter till en tätare kontakt mellan patient och vårdpersonal. Detta i syfte att lugna oroliga patienter och hjälpa till med lättare symptombedömningar och på så sätt minska väntetiderna. Genom de undersökningar som utfördes upptäcktes dock även svagheter i en telemedicinsk lösning avsedd för lungcancerpatienter. Patientgruppen ofta är äldre med liten erfarenhet av datorer och sjukdomen är allvarlig. Det krävs personlig kontakt och fysiska undersökningar, men i vilken utsträckning är individuellt. Telemedicin kanske inte kan ses som en absolut lösning för de problem som råder i sjukvården idag när det kommer till lungcancerpatienter, men väl som ett komplement. Om lungcancerpatienter är den optimala målgruppen är ifrågasättbart men att telemedicin kan underlätta i den svenska sjukvården står klart.Nowadays the health care system in Sweden is faced with several challenges like shortage of space, physicians and long distances to specialized health care. A possible solution for this being discussed at the lung cancer department of Karolinska University 2 Hospital is the use of telemedicine. If implemented it would be part of the followup treatment. The objective of our research is to find out if this technology can help improve the health care. In order to investigate the opportunity for a telemedicine solution, we collected qualitative data from multiple different sources. This included two doctors specialized in lung cancer, and a focus group with nurses from Radiumhemmet. We also conducted interviews with relevant individuals outside the hospital including Nirav Desai who is the Founder and CEO of Hands On Telehealth; furthermore, we visited the Children’s Healthcare of Atlanta based in Atlanta, Georgia where telemedicine is used on a daily basis. Thanks to the carried out research, we have discovered that telemedicine could be used in certain scenarios and contribute towards a more frequent contact between the patient and the medical professionals. Thus, this new technique could help nurses execute lighter symptoms assessment remotely and reduce waiting times. We also discovered some inconveniences in a telemedicine solution designed for lung cancer patients. We personally do not think they are the best target group for such a solution since the patients are mostly the elderly with little computer experience. Also the disease is severe and requires physical examinations where the telemedicine existing today would not improve the care giving. To all intents and purposes, telemedicine might not be the only and ultimate solution for the problems identified within healthcare for lung cancer patients at Radiumhemmet, but it can work well as a supplement. 3
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Fredrix, Elisabeth Wilhelmina Hubertina Maria. "Energy metabolism in cancer patients." Maastricht : Maastricht : Datawyse ; University Library, Maastricht University [Host], 1990. http://arno.unimaas.nl/show.cgi?fid=5567.
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Kaur, Jasmine. "Preventative Vaccine for Cancer patients." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/413312.
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Cancer is an age-old disease and a leading cause of mortality worldwide. It starts with the development of abnormal cells that multiply to form tumours and may lead to metastasis causing damage to healthy tissues and organs of the body. Lung cancer is the most common type of cancer with significant morbidity and mortality globally and is of major concern for the society. Decades of research and innovation in the treatment of cancer led to the development of certain conventional therapies such as surgery, radiotherapy, and chemotherapy that are being effectively used. However, these traditional therapies have a disadvantage of destroying healthy cells and tissues in its close proximity, leading to other severe diseases and side effects. Therefore, a much-advanced approach to treat cancer without causing severe side effects became an important area of research. Improvements in the field of anti-cancer therapies led to a strategy to combine traditional treatment approaches to destroy cancer cells. Additionally, treatments such as targeted therapies, hormone therapy, and precision medicine came into existence. Alternatively, the immune system was analysed to determine an effective approach that could control proliferation of cancer cells and cause limited or no damage to other cells. This area of cancer therapeutics, known as immunotherapy, targets the immune system to enhance its ability of recognizing invasive neoplasms. Our immune system in response to an infection immediately activates immune cells, creating a protective immunity for decades. Unfortunately, this immune response often fails when fighting against cancer and is unable to entirely eliminate tumour cells or develop effective immunity. Cancer vaccines, a branch of immunotherapy that has potential therapeutic benefits can build immunity and ultimately lead to prevention from future illness. These have been employed to treat the disease using tumour associated antigens and various adjuvants or immune stimulators and only a few have been in clinical trials. The potential of such cancer vaccines can be exploited to further develop treatment strategies to prevent tumour occurrence and provide long-lasting immunity. This study was designed to primarily explore the potential of a novel immune stimulator, RNA:DNA hybrid and an established TLR9 agonist, CpG 7909. Furthermore, these agonists were used to develop a preventative cancer vaccine in association with a tumour associated carbohydrate antigen, Globo-H to determine whether the novel formulation could improve immune response and trigger antigen presentation in vitro and in vivo. In an in vivo setting, these were also investigated against lung cancer to determine their potential in preventing tumour occurrence. Within this study RAW 264.7 mouse macrophages were initially exposed to varying concentrations of CpG 7909, RNA:DNA hybrid, and Globo-H to determine the optimum dose concentration for the activation of antigen presenting cells by measuring the level of TNF-α secreted in cell culture supernatant. Following dose optimization, the individual agents were combined in a vaccine formulation, sharing the same antigen, where two cell lines, mouse RAW 264.7 macrophages and human monocytic cell line, THP-1 that was differentiated into macrophages and dendritic cells were exposed to the vaccines. TNF-α, IL-12 and IL-6 cytokine response was analysed as measured by ELISA and real-time PCR that were determined to be partially significant in response to the vaccines. The degree of immune response demonstrated by RNA:DNA hybrid-based vaccine (HG-Vax) confirmed that HG-Vax is more effective than CpG 7909-based vaccine (CG-Vax). This response was further analysed in an in vivo model where C57/BL mice were exposed to immune stimulators and vaccines separately for 14- and 28-days before end point termination. Serum was analysed for IL-12 and TNF-α to determine the level of inflammatory response. Even though statistical significance was not achieved in vivo, contrasting observations compared to the in vitro model were exhibited. Secretion of IL-12 in animals confirmed the induction of an anti-tumour immune response. Interestingly, cytokines induced by single dose CG-Vax persisted for a longer period of time in blood in comparison to HG-Vax. However, opposite was true with the booster immunization. In animal model of lung cancer, statistical significance validates that booster immunization with HG-Vax triggers an immune response and upregulates MHC II expression. Unfortunately, CG-Vax did not induce a significant immune response and failed to induce MHC II expression in an in vivo model of lung cancer. Although these findings present RNA:DNA hybrid to be a novel immune stimulator that may have the potential to be used in future cancer vaccinations, further investigation on its immunological potential and mechanism of action remains of need.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Pharmacy & Med Sci
Griffith Health
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McMenamin, Úna. "Pharmacological exposures, cancer treatments and disease progression among cancer patients." Thesis, Queen's University Belfast, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.679267.
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The evidence base for the effect of common pharmacological exposures among patients diagnosed with cancer is sparse. Routinely collected health data however, can facilitate the conduct of pharmacoepidemiological research into cancer care and outcomes. This PhD study comprised (i) a systematic review of angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) use and cancer progression and survival; (ii) a systematic review and meta-analysis of non-steroidal anti-inflammatory drug (NSAID) use and colorectal cancer outcomes; (iii) a nested-case control study of ACEI and ARB use and risk of breast cancer mortality; (iv) a nested-case control study of ACEI and ARB use and risk of prostate cancer mortality and; (v) an overview of cancer treatments received among women, recently diagnosed with breast cancer in Northern Ireland. Individual studies identified within the first systematic review showed inconsistencies with respect to the association between ACEls/ARBs and cancer outcomes and following on from this, findings from two large population-based studies indicated little evidence of a beneficial association between ACEI or ARB use and breast and prostate cancer mortality outcomes, respectively, although a possible protective association was noted for ACEls and risk of prostate cancer mortality. Similarly, there was limited evidence to suggest an association between NSAID use and clinical outcomes from colorectal cancer, based on findings from the second systematic review and meta-analysis. Using data sources from within the Northern Ireland Cancer Registry, a retrospective population-based dataset of breast cancer patients, recently diagnosed in Northern Ireland was constructed. Cancer treatments were deemed appropriate and particular attention was given to adjuvant systemic therapies (including chemotherapy and hormone therapy). This dataset will enable future data linkage with dispensed medication records. Considering the frequency with which ACEls, ARBs, as well as NSAIDs are prescribed, further research into cancer outcomes with respect to these agents is warranted.
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Wolfman, Jessica Heather Kloss Jacqueline D. "Cancer specific stress and insomnia severity among breast cancer patients /." Philadelphia, Pa. : Drexel University, 2009. http://hdl.handle.net/1860/3024.
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Radu, Calin. "Optimising Radiotherapy in Rectal Cancer Patients." Doctoral thesis, Uppsala universitet, Enheten för onkologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172531.
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Rectal cancer is the eight most common cancer diagnosis in Sweden in both men and women, with almost 2000 new cases per year. Radiotherapy, which is an important treatment modality for rectal cancer, has evolved during the past decades. Diagnostic tools have also improved, allowing better staging and offering information used to make well-founded decisions in multidisciplinary team conferences. In a retrospective study (n=46) with locally advanced rectal cancer (LARC) patients, unfit for chemoradiotherapy, patients were treated with short-course radiotherapy. Delayed surgery was done when possible. Radical surgery was possible in 89% of the patients who underwent surgery (80%). Grade IV diarrhoea affected three elderly patients. Target radiation volume should be reduced in elderly or metastatic patients. In a prospective study (n=68) with LARC patients, magnetic resonance imaging (MRI) and 2-18F-fluoro-2-D-deoxyglucose (FDG) positron emission tomography (PET) were used to determine if FDG-PET could provide extra treatment information. Information from FDG-PET changed the stage of 10 patients. Delineation with FDG-PET generally resulted in smaller target volumes than MRI only. Seven of the most advanced LARC patients in the above cohort were used for a methodological study to determine if dose escalation to peripheral, non-resectable regions was feasible. Simultaneous integrated boost plans with photons and protons were evaluated. While toxicity was acceptable in five patients with both protons and photons, two patients with very large tumours had unacceptable risk for intestinal toxicity regardless of modality. In the interim analysis of the Stockholm III Trial (n=303, studying radiotherapy-fractionation and timing of surgery in relation to radiotherapy) compliance was acceptable and severe acute toxicity was infrequent, irrespective of fractionation. Short-course radiotherapy with immediate surgery tended to give more postoperative complications, but only if surgery was delayed more than 10 days after the start of radiotherapy. Quality-of-life in the Stockholm III Trial was studied before, during and shortly after treatment using the EORTC QLQ-C30 and CR38 questionnaires. Surgery accounted for more adverse effects than radiotherapy in all groups. Postoperatively, the poorest quality-of-life was seen in patients given short-course radiotherapy followed by immediate surgery. No postoperative differences were seen between the two groups with delayed surgery.
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Nna, Emmanuel Okechukwu. "Molecular profiling of prostate cancer patients." Thesis, Cranfield University, 2009. http://dspace.lib.cranfield.ac.uk/handle/1826/4527.
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In the UK, more than 30 000 men are diagnosed annually with prostate cancer (PCa) and about 10 000 men die from it each year. Although several molecular markers have been associated with prostate cancer development and/ or progression, only few of them are used in diagnostic pathology. The current standard tests include serum PSA test, digital rectal examination and histology of prostate biopsy. Recently the PCA-3 molecular test was approved in the European Union, and it is now used in many laboratories. But these tests are not sufficient to molecularly characterise the behaviour of prostate cancer in many patients. Through extensive literature review, a panel of sixteen molecular markers were selected for further evaluation in prostate cancer cases. They included KLK2, KLK3, MCM2, MCM5, TP53, Bcl-2, CD44, CDH1, AURKA, AURKB, and AURKC; ESR , ESR , AR, FASN, TMPRSS2: ERG, and TMPRSS2:ETV1. The aim was to examine the link between development/progression of prostate cancer and the production of diagnostic/prognostic biomarkers. An in vitro model consisting of PC-3 and PNTIA, MDA PCa 2b prostate cell lines were used to investigate the influence of steroid hormones on these biomarkers using molecular and proteomic techniques. All the three cell lines expressed AR, ESR , ESR and PSA at mRNA and protein levels. The AR expressed in PC-3 and MDA PCA 2b cells was 60 kDa while the PNT1A expressed a 90 kDa AR protein. The ESR was over-expressed in the MDA PCA 2b cells, and was also significantly up-regulated by 17 oestradiol treatment. At a concentration of 4.92 and 33.96μM 17 oestradiol inhibited the growth of 10 to 50% of PNT1A cell line and increased the doubling time three folds. Although the PC-3 cells expressed AR, it was still androgen insensitive and could not produce PSA in culture supernatants. AR and PSA were up-regulated in PNT1A cells in response to testosterone and dihydrotesterone treatment but were reduced in response to 17 oestradiol and Hydrocortisone treatment. All the molecular markers except the TMPRSS2: ERG and TMPRSS2:ETV1 were expressed in the cell lines. The MCM2 and MCM5 were not differentially expressed in response to hormonal treatment. However, the Aurora kinases A, B and C were up-regulated in response to steroid modulation. The KLK2 was only up-regulated by the androgens. Three candidate control genes: ABL1, GUS and G6PD were also evaluated in the cell lines and clinical samples; the ABL1 gene emerged as the most stably expressed house keeping gene and was subsequently used in the normalization of real time PCR assays (RQ-PCR). Analysis of the sixteen biomarkers in prostate tissues and exfoliated urine cells of benign, prostate cancer and non-involved cases (n = 228) showed that seven of the molecular markers were significantly strongly associated with prostate cancer progression (P<0.05). The Aurora kinases A and B were consistently significantly over-expressed in prostate cancer cases. The CD44 was also over-expressed in prostate cancer, and was associated with Gleason score. The TMPRSS2 fusion genes were detected in 15.6% of the prostate cancer cases. The TP53 was also over-expressed in prostate cancer, and significantly associated with tumour grade. The ESR was over-expressed in prostate cancer, and was significantly associated with high tumour grade. This implied a proliferative role for the ESR in prostate cancer progression, because the ESR was not differentially expressed among the sample groups. Concomitantly, the AR was also over-expressed in same pattern with ESR . The combination of these biomarkers: AR, ESR , CD44, TP53, TMPRSS2 fusion genes, AURKA and AURKB could molecularly characterise most prostate cancers. Therefore 2 sets of pentaplex RQ-PCR assays including ABL1 for normalization would provide a cost-effective, flexibly high throughput assay for molecular grading of tissue sections in diagnostic pathology. In addition to the gene expression studies, the genetic variation in KLK2 gene was further investigated by direct DNA sequencing, pyrosequencing and TaqMan allelic discrimination assay. Two SNPs in the gene were found significantly associated with prostate diseases. The T/T allele of rs198977 predicted the presence of prostate cancer at biopsy and was associated with high tumour grade. The A/A variant of rs2664155 was also significantly associated with the presence of benign nodular hyperplasia. The combination of gene expression and genetic variation using real time PCR applications would provide an accurate, reproducible and cheap method for molecular profiling of prostate cancer patients. An exploratory study of organic volatiles in urine of one prostate cancer patient and eight BPH patients using thermal desorption GC-MS showed that Ethanethiol, Dimethyl sulfide, Propyn-1-ol acetate, Nitro-2-propanone, pentane, Hydrazine and Nitrous oxide were differentially over-expressed in the prostate cancer patient compared to the benign cases. Further studies would be required to rule out possible contamination and drug metabolites.
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Viganó, Antonio Angelo Luciano. "Survival predictors in advanced cancer patients." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0007/MQ28996.pdf.
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Persson, Christina. "Improved Nutritional Support in Cancer Patients." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5218-3/.
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Chan, Chun-wai Raymond. "Bereavement of spouses of cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B29726694.
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Dhanbhoora, Khushnud A. "Spousal communication among patients with cancer." Virtual Press, 2007. http://liblink.bsu.edu/uhtbin/catkey/1364940.
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Using primarily grounded theory methodology, the purpose of this study was to understand how the experience of cancer affects communication patterns in married couples where one spouse has been diagnosed with cancer. Nine couples, five in which women were diagnosed with cancer and four in which men were diagnosed with cancer, were interviewed individually. They were asked questions pertaining to changes in their relationship and communication patterns since the diagnosis of cancer. Potential barriers and facilitators to communication were explored. Additionally, gender differences that could play a role in these marital communication patterns were examined. Participants were also administered a measure of mood states, the Profile of Mood States (POMS) and, a measure of family cohesion, flexibility and communication, the Family Adaptability and Cohesion Evaluation Scale-version IV (FACES IV). Findings from both qualitative and quantitative methods were triangulated.Information gathered from the interviews generated eight themes: initial reactions to diagnosis, the experience of cancer, coping strategies, impact of cancer on the spousal relationship, spousal communication prior to cancer, spousal communication since the diagnosis of cancer, barriers to communication, and impact of gender and gender role on communication and adjustment. These categories and their subcategories generated an integrated grounded theory on the dimensions of communication. The theory consisted of three interactive elements: facilitators of communication, barriers to communication and the role of gender.Findings from this study confirmed existing trends in the current literature on communication among couples facing cancer. Results demonstrated that the experienceof cancer and its treatment brought couples closer to each other, where they experienced increased intimacy and communication with their spouses. There were several factors that facilitated these changes. On the other hand, barriers to communication were also identified; however, some of these barriers also served as coping strategies for participants. Furthermore, although there were differences and similarities noted among men and women in the study, results highlighted the importance of viewing them within the context of each participant's role as a patient and a caregiver, and not merely as a result of gender.Several research and practice implications are presented. Results of this study can help health care and mental health professionals gain a better understanding of the needs of cancer patients and their families. Couples and families can also benefit from an awareness of specific facilitators and barriers to communication.Department of Counseling Psychology and Guidance Services
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Blackwelder, Reid B. "Integrative Approaches to Patients with Cancer." Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/6987.
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Vittatoe, Danielle S., and L. Lee Glenn. "Effects of Telemonitoring in Cancer Patients." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/7473.
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Motenko, Jill Swartwout. "The Spiritual Quests of Cancer Patients." Antioch University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1329323769.
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Allen, Denise M. "Future orientation of adolescent cancer patients /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487758178237076.
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Rattican, Debra. "Symptom Clusters in Lung Cancer Patients." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/352.
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SYMPTOM CLUSTERS IN LUNG CANCER PATIENTS By Debra Rattican, PhD, RN A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2012 Major Director: Debra E. Lyon, PhD. Professor and Chair Family and Community Health Nursing The purpose of the study was to examine selected relationships among symptoms common to individuals with lung cancer. The specific aims were: 1) To examine the relationship between the symptoms of dyspnea and anxiety in patients with lung cancer. 2) To examine the relationships among the symptoms of dyspnea, anxiety, and symptom cluster components (depressive symptoms, fatigue, pain) in patients with lung cancer. 3) To examine the correlation between functional ability and quality of life in patients with lung cancer. 4) To explore the relationships among the symptoms of dyspnea, anxiety, and symptom cluster components (depressive symptoms, fatigue, pain) in patients with lung cancer and patients’ functional ability. 5) To explore the relationships among the symptoms of dyspnea, anxiety, and symptom cluster components (depressive symptoms, fatigue, pain) in patients with lung cancer and patients’ quality of life. Data were gathered through online survey and analyzed using descriptive, correlation, principal component analysis, exploratory factor analysis, and forward stepwise regression techniques. A strong positive correlation was found between dyspnea and anxiety (both anxiety in general and anxiety at the time the survey was completed. While results of this study cannot provide conclusive evidence of the existence of a symptom cluster composed of depressive symptoms, fatigue, and pain, the results are consistent with other studies in this area. Significant positive correlations among these three symptoms indicate that this is a possible symptom cluster experienced by lung cancer patients in general. This study provides preliminary data on how these symptoms are related and how they affect functional ability, or the ability to perform routine activities of daily living (ADLS) and instrumental activities of daily living (IADLS), and quality of life in patients with lung cancer. Further study is needed on to better understand the symptom experience of these individuals in order to develop robust interventions targeting effective symptom management.
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Pietrucin-Materek, Marta. "Patients' preferences for cancer follow-up." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=223919.
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Introduction As a result of the growing and ageing population in developed countries, improved cancer detection and advances in cancer treatments, there are more people living with cancer for longer. The rising number of cancer survivors and increasing demand for oncology services, has sparked interest in alternative ways of delivering cancer follow-up care. Although a number of alternative cancer follow-up strategies have been developed, information about the relative importance of different characteristics of follow-up and how people trade between these characteristics is still limited. Aims and objectives The overall aim of the thesis was to understand what characteristics (called attributes and levels) of cancer follow-up services are important to survivors of cutaneous melanoma, breast, prostate and colorectal cancer; whether people make trade-offs between these characteristics; and whether survivors of different cancers with different personal characteristics express different preferences for cancer follow-up care. The aim was met by a number of objectives: •To conduct a review of the literature to gather information about characteristics of follow-up that are important to people. • To conduct semi-structured qualitative interviews with cancer survivors living in North East Scotland, to determine their views of current care and preferences for future cancer follow-up. • Based on the findings from the literature and semi-structured interviews, to determine characteristics (attributes and levels) of cancer follow-up services for inclusion in a discrete choice experiment. • To develop and carry out a discrete choice experiment to establish the relative importance of a number of attributes of cancer follow-up amongst cancer survivors treated and followed up for cutaneous melanoma, breast, prostate and colorectal cancer.
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Dasch, Kimberly B. "Affective differentiation in breast cancer patients." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 70 p, 2009. http://proquest.umi.com/pqdweb?did=1885670961&sid=7&Fmt=2&clientId=8331&RQT=309&VName=PQD.
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Ku, Wai-yin Ellen. "An exploration of the communication needs of cancer patients." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22078988.
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Knecht, Vicky Marie. "PATIENTS WITH GYNECOLOGICAL CANCER: COMPARISON OF LEARNING NEEDS OF PATIENTS AND THEIR SIGNIFICANT OTHERS." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/292091.
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Zucchero, Renee A. "Marital adjustment of older adult couples with breast cancer, prostate cancer, and couples without cancer." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1117099.
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The purpose of this study was to explore the marital adjustment of older adult couples with breast cancer, prostate cancer, and couples who have experienced neither. Participants were 64 couples in which at least one of the spouses was over 55 years of age, including 19 breast cancer couples, 20 prostate cancer couples, 25 couples who had experienced neither of these cancers. Most participants were young-old, Protestant, Caucasians from a high socioeconomic class. The breast cancer and prostate cancer participants had completed treatment an average of 39.5 months prior to participation. The methodology was a mail survey. Participants completed a demographic questionnaire, the Marital Satisfaction Questionnaire for Older Adults (MSQFOP) (Haynes et al., 1992), Primary Communication Inventory (PCI) (Navran, 1967), Miller Social Intimacy Scale (MSIS) (Miller & Lefcourt, 1982), and the Index of Sexual Satisfaction (ISS) (Hudson et al., 1981).There were no differences in the amount of discordance between the couples groups' level of marital satisfaction, communication, intimacy, and sexual satisfaction. In addition, there were no differences in the level of marital satisfaction, communication, intimacy, and sexual satisfaction between the participant groups. There was a significantly greater correlation between the prostate cancer couples' scores on the ISS than the correlation between the breast cancer couples' scores and the scores of the couples who had not experienced breast cancer or prostate cancer.The level of marital satisfaction, communication, intimacy, and sexual satisfaction reported was similar to that of the normative samples. There was no difference between the marital adjustment of the cancer couples and older couples who had experienced neither type of cancer. These results are good news for breast and prostate cancer survivors, and professionals. Older adults may be better able to incorporate the experience of cancer into their lives or are better prepared for chronic illness through anticipatory socialization. The high degree of agreement between the prostate cancer spouses on the ISS may be related to the sexual dysfunction that frequently accompanies treatment for this cancer. Future research should be qualitative and longitudinal and continue to explore the psychosocial implications of prostate cancer.Center for Gerontology
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Bashir, Kifah, and Yvonne Bengtsson. "Palliative care for pancreatic cancer - patients´ experiences." Thesis, Kristianstad University College, Department of Teacher Education, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-4609.
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To receive a diagnosis of pancreatic cancer can lead to a tremendous change in a person’s life. Thoughts regarding death may cause a personal crisis which can have negative influences on the patient’s social, mental and spiritual state. Most people with pancreatic cancer are diagnosed in a late stage of the disease. Therefore, palliative care is often one of the options that are offered to patients. Moreover, to be able to provide patients with nursing care and tend to their needs, it is very important to see them as unique individuals. The purpose with the literature review was to illustrate the experiences of palliative nursing care of patients with pancreatic cancer. A systematic literature review of scientific articles was performed. The study showed that patients’ experiences of need for information, patients’ need for time, support and personal relations, patients’ experiences of hope as well as patients’ need for symptom control were of importance in palliative nursing care.
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Al, Shehhi Ruqaiya Mohammed. "Emergency management of patients with colorectal cancer." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58335.
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Background: According to the literature, up to 30% patients with colorectal cancers (CRCs) present to the emergency department (ED) with surgical emergencies. The most common surgical presentations of these patients are: intestinal obstruction, perforation and bleeding. Palliative surgical interventions in these patients are believed to carry high risks of morbidity and mortality. Moreover, management options tend to be individualized in most cases, if not all.
Methodology: A systematic review of published literature was conducted. Articles meeting inclusion criteria were summarized. Quantitative data regarding study characteristics were analyzed and expressed as descriptive statistics. Primary outcomes of interest were post-operative complications, mortality and 5-year disease free status.
Results: 304 articles were collected from searching online data bases. Eight articles were found to match the research question and underwent a full text review. Five more articles were added from searching the grey literature. After final review, 11 articles were selected to be included in the systematic review.
Papers were assessed for methodological validity. 81.8% of studies used regression models in their analyses. Mean number of patients included in the papers was 3,567 (min= 145, max= 30,790). 50.2% of all patients were males. Most of the included studies reported mean age of more than 60 years. The mean follow-up period in days was 399.5. Analysis of different variables revealed that, CRC patients who received emergency surgery had more comorbidities (95% CI, OR=1.42 P=0.05), higher American Society of Anesthesiology classes (95% CI, OR=1.33 P=0.08), and more advanced disease (95% CI, OR=1.09 P=0.02) than CRC patients who receive surgical intervention on elective basis. Moreover, resection rate was higher in the elective group (95% CI, OR=0.5 P=0.04). In contrast, stoma creation rate was higher in the emergency group (95% CI, OR=5.08 P=0.003). Furthermore, emergency patients had higher rates of postoperative complications (95% CI, OR=4.6 P=0.007) and mortality (95% CI, OR=5.38 P=0.0001).
Conclusion: Patients requiring emergency surgery for CRC often have complex comorbidities and acute instability, and are at very high risk of postoperative complications. These findings highlight an important opportunity for the development of comprehensive systems of emergency surgical care, and, ultimately, improvement of patient outcomes.Medicine, Faculty of
Surgery, Department of
Graduate
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Somerville, Caroline Laura. "Quality of life of colorectal cancer patients." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/26954.
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Purpose: The aim of this study was to investigate the long term quality of life of colorectal cancer patients who had undergone either sphincter conserving or sphincter sacrificing surgery. It was predicted that patients who underwent sphincter-sacrificing surgery resulting in the formation of a stoma would report an inferior quality of life as indicated across several domains of quality of life compared to patients with no stoma. Method: Thirty two patients completed a battery of questionnaires measuring quality of life at an interval of between twelve and eighteen months post surgery. Quality of life was measured using two questionnaires developed by the European Organisation for Research and Treatment of Cancer: one for cancer specific quality of life (EORTC QLQ-C30) and the supplementary colorectal cancer specific module (EORTC QLQ-CR38, Aaronson et al., 1988); Hospital Anxiety and Depression Scale (HADS, Zigmong & Snaith, 1983); Body Image Scale (BIS, Hopwood, Fletcher, Lee & Al Ghazal, 2001). Data analysis: Patient age, length of time since surgery and scores on the measures were compared using independent samples t-tests. Length of time since surgery was analysed using covariance. Person’s correlation co-efficient was used to test for the level of association between measures. Results: No significant differences between the sphincter conserving and sphincter sacrificing groups were found on several domains of quality of life assessment including, physical, social, psychological and role functioning and levels of post-surgery symptoms. Significant differences were found between patients in relation to body image satisfaction and male sexual problems. Patients with a stoma showed more dissatisfaction with their body image than patients without a stoma. Males with a stoma were found to report more sexual problems than males without a stoma. Results are discussed in relation to previous research and in terms of implications for further research and psychosocial aspects of care for colorectal cancer patients.
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Eaden, Jayne Alison. "Colorectal cancer in patients with ulcerative colitis." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29610.
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The magnitude of the colorectal cancer (CRC) risk in ulcerative colitis (UC) was determined in the first meta-analysis of all 116 studies reporting the risk. For any patient with UC the risk was 2% at ten years, 8% at twenty years and 18% after thirty years. The risk was greater in children, varied geographically and has fallen since 1955. A case-control study of 204 patients across the United Kingdom demonstrated regular aminosalicylate therapy reduced cancer risk by 75% (p<0.00001). Mesalazine was particularly effective reducing risk by 81% (p=0.006). Visiting a hospital doctor more than twice a year and attending regular colonoscopies also reduced risk (84% and 78%). A family cancer history increased risk five fold. A reliable, self administered questionnaire measuring patient knowledge was developed. No correlation was found between patient knowledge and the risk of developing CRC. A randomized controlled trial compared the efficacy of a video (scripted and produced by the author) vs. an information leaflet on patient knowledge. This established that both media improved knowledge (71% and 49%) but neither intervention was significantly more effective than the other. The first nationwide audit of surveillance practices amongst gastroenterologists ascertained 94% of consultants practiced surveillance but it was extremely disorganized and considerable disagreement existed concerning the management of dysplasia. A new immunohistochemical marker for dysplasia (CYP1B1) was investigated. Although CYP1B1 showed faint staining in dysplastic tissues, it was inconsistent and presently would not improve identification of dysplasia. The CRC risk in UC is significant and may be modified through regular consumption of aminosalicylates. Resources may be better allocated at improving compliance with such medication and targeting surveillance on high risk patients. Standardization of surveillance through national guidelines is needed urgently.
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Ringash, G. Jolie. "Quality of life in laryngeal cancer patients." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0002/MQ45919.pdf.
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Burge, Frederick. "Dehydration symptoms of palliative care cancer patients." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60446.
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Controversy exists among clinicians and caregivers as to whether reduced fluid intake contributes to the suffering of those dying of advanced cancer. This study explored the distribution of proposed "dehydration state" symptoms among inpatient palliative care cancer patients. Fifty-two subjects responded to a seven item self-report questionnaire using visual analogue scales. Associations were determined between the symptom self-reports and the possible predictor variables fluid intake, serum sodium, urea and osmolality. Confounding variables considered were age, oral disease and mouth care regime. Mean symptom ratings (range 0-100 mm) were: thirst 53.8, dry mouth 60.0, bad taste 46.6, nausea 24.0, pleasure to drink 61.6, fatigue 61.8, and pain 33.5. No significant association was determined between symptom ratings and the predictor or confounding variables. Although the symptoms appear to be rated moderately severe, there was no demonstrable association between severity and fluid intake, the key concern of clinicians and families.
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Tang, Wai-ha Sherman, and 鄧惠霞. "Quality of life of gynaecological cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B43893521.
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Moretto, Patricia. "Thromboprophylaxis in Hospitalized Medically Ill Cancer Patients." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30656.
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Introduction: Thromboprophylaxis recommendations for hospitalized cancer are based on trials done for the general medically patients, as there are no randomized clinical trials(RCTs) looking at thromboprophylaxis in medically ill patients with cancer. Methods: To determine if thromboprophylaxis is safe and effective to prevent VTE these patients, a Systematic Review(SR) was done. A survey was performed to assess: clinical equipoise, trial design and minimally clinically important difference(MCID) for a potential trial. Lastly, a pilot study for an RCT was designed. Results: The pooled RR of VTE was 0.91 (95%CI:0.21 to 4.0;I2:68%) among hospitalized cancer patients receiving thromboprophylaxis compared to placebo. 63.9% believe there is clinical equipoise and 58.3% would consider participating in a RCT comparing different agents/dosing. The MCID for absolute reduction in symptomatic VTE between two arms was 2% and for “acceptable” increase in major bleeding events was 1%. Conclusion: The risk-benefit ratio of current doses of thromboprophylaxis administered to hospitalized cancer patients is unclear and additional RCTs are necessary.
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Wattanatorn, Wiboon. "Pharmacokinetics of 5-fluorouracil in cancer patients." Thesis, Robert Gordon University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389482.
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Bossaer, John B., and Kelly L. Covert. "Direct Oral Anticoagulants in Patients with Cancer." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7793.
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Purpose:This review summarizes the available evidence concerning direct oral anticoagulant (DOAC) use to treat venous thromboembolism (VTE) in patients with cancer as well as pertinent safety data on the use of DOACs in patients with both cancer and atrial fibrillation.
Summary:The introduction of DOACs into clinical practice changed the way thrombotic complications are managed and prevented in diverse patient populations, including VTE and atrial fibrillation. Low-molecular-weight heparins have been the standard of care for treating VTE in cancer patients due to superiority over vitamin K antagonists in preventing recurrent VTE. Therefore, widespread DOAC use for VTE in patients with active cancer has not been adopted.
Conclusion:Recent randomized clinical trials (SELECT-D, Hokusai VTE Cancer) have provided evidence that DOACs may have a role in treating VTE in cancer patients.
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Meikle, Claire K. "Platelet-Leukocyte Aggregation in Lung Cancer Patients." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1555937904448281.
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Hertting, Rosemarie. "Providing spiritual care for patients with cancer /." Staten Island, N.Y. : [s.n.], 1996. http://library.wagner.edu/theses/nursing/1996/thesis_nur_1996_hertt_provi.pdf.
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Tang, Wai-ha Sherman. "Quality of life of gynaecological cancer patients." Hong Kong : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13990949.
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Sands, Megan Bernice. "DETECTION OF DELIRIUM IN HOSPITALISED CANCER PATIENTS." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18948.
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Delirium is an important syndrome associated with poor outcomes for patients, carers and staff. The incidence and prevalence of delirium in people with cancer in the hospital in-patient setting, is not established. The few studies from this setting, report wide-ranging incidence and prevalence rates. Similarly, some data exist relating to reversibility of delirium in the index setting, but not a great deal is known about reversibility. Delirium detection is critical for treatment, but not well established for in-patient oncology settings. The first chapter of this thesis is a scoping review of the literature relating to incidence, prevalence and reversibility of delirium in the index setting. In addition, we sought to determine which delirium screening tools and which reference standards were used as the basis of case ascertainment to underpin epidemiological studies. Critical appraisal of methodological constraints of the studies was considered and the implications for knowledge gaps were identified. The second chapter reports findings from our original study investigating the clinical utility of the Single Question in Delirium (SQiD), a novel tool which was previously developed by the author. The methodological approach compared the SQiD against clinical review by consultant liaison psychiatrists in admitted, oncology patients. In summary this thesis provides a synthesis of knowledge to August 2017 relating to the epidemiology of delirium in admitted cancer patients and tests a short pragmatic delirium screening tool against a diagnostic reference standard. It contributes to the knowledge base relating to delirium in cancer patients admitted in the acute setting and is hypothesis generating for future research.
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Crabtree, Melody A. "Self reported effect of patient education on stress and decision making in newly diagnosed cancer patients." Virtual Press, 2000. http://liblink.bsu.edu/uhtbin/catkey/1191706.
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Educational programs covering the technical, treatment and emotional aspects of a cancer diagnosis have been shown to reduce anxiety levels, boost compliance with treatment regimens and improve survival rates. This study was designed to evaluate whether newly diagnosed cancer patients, after reviewing an educational intervention, felt they experienced decreased stress levels and more informed decision making ability. A descriptive, evaluative study was designed. Seventy-five newly diagnosed cancer patient's evaluation forms were examined. Responses were reviewed to see if these patients placed an important versus unimportant value on the individual components of an educational packet. Their responses were tallied and the results showed that an overwhelming majority of the patients felt that the packet components were important in helping them feel decreased stress levels and more informed in their decision making regarding their diagnosis of cancer. It was also determined that the majority of patients felt that the packet components were easy to understand.Department of Physiology and Health Science
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Broz, Stefne Lenzmeier. "The role of information in cancer patients' involvement in their cancer care." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1070390568.
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Broz, Stefne Lenzmeier. "The role of information in cancer patients' involvement in their cancer care." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1070390568.
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Thesis (Ph. D.)--Ohio State University, 2003.Title from first page of PDF file. Document formatted into pages; contains x, 97 p. Includes bibliographical references (p. 88-97). Available online via OhioLINK's ETD Center
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Simonich, Heather K. "Sex differences in social support among cancer patients." Virtual Press, 2001. http://liblink.bsu.edu/uhtbin/catkey/1222834.
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Social support is likely to play an especially important role in coping with a cancer diagnosis as it presents a unique set of stressors to the individual. The purpose of this study was to examine biological sex differences in the perceived availability of three modes of social support (emotional, instrumental, and informational), source of support (friends vs. family), and social support seeking behavior in a population of cancer patients. The sample included 71 men and 71 women who had been diagnosed with cancer within two years of the start of the study. No significant sex differences were found in social support seeking; however, results revealed that women perceived greater availability of emotional support as well as greater support from friends on all modes of social support than did men. Implications of these findings and future directions for research are discussed.Department of Counseling Psychology and Guidance Services
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Ramroth, Johanna Rankin. "Radiotherapy dose-fractionations and outcomes in cancer patients." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:8c5a99de-7d8c-4b19-9a91-e6cf4efa7bd2.
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Radiotherapy cures many cancers, but the optimum total doses and fractionations used to treat different cancer types remain uncertain. While conventional fractionation (≈2 Gy per fraction) is common in many countries, UK practice has been highly variable. This thesis compared different curative-intent radiotherapy dose-fractionations used in non-small cell lung and breast cancer. These two cancers together make up over a quarter of UK cancer incidence and mortality, and radiotherapy can increase cure rates of both cancers. Two studies were conducted: (A) A meta-analysis of randomised radiotherapy trials in non-small cell lung cancer and (B) A cohort study of non-small cell lung and breast cancer radiotherapy in the Thames Valley. For the meta-analysis, a systematic search was conducted. Eligible studies were randomised comparisons of two or more radiotherapy regimens. Median survival ratios were calculated for each comparison and pooled. 3,795 patients in 25 randomised comparisons of radiotherapy dose were studied. When radiotherapy was given alone, the higher dose within-trial resulted in increased survival (median survival ratio 1.13, 95% confidence interval 1.04-1.22). When radiotherapy was given with concurrent chemotherapy, the higher dose within-trial resulted in decreased survival (median survival ratio 0.83, 95% confidence interval 0.71-0.97). For the cohort study, multiple Public Health England data sources were combined to obtain information on radiotherapy, patient characteristics, and outcomes. Multivariable Cox regressions were conducted separately by cancer site. 324 non-small cell lung, 8,879 invasive breast, and 477 ductal carcinoma in situ patients were studied. In analyses of both non-small cell lung and invasive breast cancer, increasing radiotherapy dose was associated with improved survival in some treatment centres, while in other centres the opposite was true. These opposite trends by treatment centre were unlikely to be explained by chance, and they suggest that differences in patient selection were driving results. There were insufficient events among ductal carcinoma in situ patients to assess associations. Findings from the meta-analysis support consideration of further radiotherapy dose escalation trials, making use of modern methods to reduce toxicity. Findings from the cohort study suggest that it is not possible to use observational studies to examine causal effects of radiotherapy dose-fractionation. This thesis therefore shows the continued importance of conducting sufficiently large randomised trials to ascertain optimal dose-fractionation in radiotherapy.
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Sorlin, Michel. "Cancer du pancréas exocrine : à propos de 115 patients." Saint-Etienne, 1995. http://www.theses.fr/1995STET6204.
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Kooken, Wendy Carter. "Vigilance Experiences: Cancer Patients, Family Members, and Nurses." Thesis, Connect to resource online, 2008. http://hdl.handle.net/1805/1849.
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Thesis (Ph.D.)--Indiana University, 2008.Title from screen (viewed on August 27, 2009). School of Nursing, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Joan Haase, Janet Carpenter, Patricia Ebright, Rangaraj Ramanujam. Includes vita. Includes bibliographical references (leaves 303-316).
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Cheng, Wing-ming Edward. "Emotional well-being in Chinese lung cancer patients." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B3197157X.
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Oldervoll, Line Merethe. "Physical activity and exercise interventions in cancer patients." Doctoral thesis, Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, 2006. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-1685.
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Alburai'Si, Kholoud Mubarak. "Stratification of breast cancer patients : a proteomic approach." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/stratification-of-breast-cancer-patients(a8102723-9f21-4495-8401-d3e8ce503968).html.
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Breast cancer represents a heterogeneous collection of different diseases characterized by different pathological and biological features, clinical presentation, clinical behaviour, response to treatment and outcome. In current practice, pathological diagnosis and classification of breast cancer is based mainly on well-established traditional morphologic features. However, morphological features alone do not adequately reveal the molecular heterogeneity and complexity of breast cancer. Still, there are relatively few biomarkers widely used in prognostication in invasive breast cancer and in predicting response to targeted therapies, and even fewer of value in the clinical management of the pre-invasive disease of ductal carcinoma in situ (DCIS). There is therefore an unmet need for biomarkers for better classification, better prediction of prognosis and of prediction of response to therapy for both invasive breast carcinoma and DCIS. The co-expression of a HER2/HER3 combination results in more aggressive tumour growth and is associated with endocrine and chemotherapy resistance, driven not simply by receptor expression but also by signalling via the receptors dimers. Therefore, methods which directly query signalling pathway activation in breast cancer specimens are anticipated to provide important insights into the molecular ‘‘logic’’ that distinguishes cancer from normal tissues and potentially to have an important impact on personalized intervention strategies. The aim of this thesis has been directed at evaluating candidate biomarkers in breast cancer. This has been targeted at examining attributes associated with known functional properties of candidate drivers of disease or resistance to treatment rather than those traditionally based on altered expression of these biomarkers. Specifically, the work was directed at the HER1-3 members of the EGFR family of growth factor receptor in breast cancer. In this project I have in part developed, tested and evaluated two methods, which have the ability to detect protein-protein complexes at a single molecule level and thus allow the study of signalling pathways in situ. The first method is an in-house coincidence detection technology created from two recombinant fusion proteins and the second is a commercially available proximity ligation assay (PLA) method. Both approaches were able to detect the target proteins with high sensitivity and specificity, however the proximity ligation assay was subsequently used here to assess the protein complexes and activation status of the EGFR family in breast cancer patient’s samples. The patient study cohort is derived from a consecutive series of approximately 293 cases of primary operable invasive breast cancers obtained from the Guy’s and St Thomas (King’s Health Partner’s) Breast Cancer Biobank archive presenting between 1990 and 1992. In these cases, 9 different biomarkers were studied for HER family expression level, dimer expression and activation status using proximity ligation assays (PLAs). The relationship between HER activation status, dimer expression and relapse free survival (RFS) was investigated and stratified multivariate regression analysis identified factors influencing patient prognosis. In conclusion, PLA successfully and reproducibly detected HER protein complexes and phosphorylation in vivo. A significant association was identified between high levels of phosphorylated HER2 and reduced recurrence-free survival (RFS) in invasive lobular carcinoma (p = 0.04, HR 0.99, 95% CI: 0.997-1.002). High levels of HER1/HER3 dimers were associated with reduced RFS in T1 (<2cm) breast cancer patients, (p = 0.02, HR 1.84, 95% CI: 1.08-3.13). Similarly, high levels of HER1/HER3 and HER2/HER3 dimers were associated with reduced RFS in breast cancer patients with N1 nodal status (p <0.0001, HR 1.84, 95% CI: 0.58-1.93) and (p <0.0001, HR 0.64, 95% CI: 0.45-0.90) respectively). Work in this thesis demonstrates that in situ detection of HER protein complexes and activation status can be monitored robustly and with specificity in clinical specimens, providing novel prognostic information. This technique was also applied successfully to assess the HER family in a smaller number of DCIS cases. This novel technique and approach could potentially be applied for patient stratification and assist in the selection of more individualized treatment options according to tumour molecular characteristics.
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Beyer, Kathryn. "Depression in patients with cancer receiving adjuvant chemotherapy." University of Southern Queensland, Faculty of Sciences, 2009. http://eprints.usq.edu.au/archive/00006177/.
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This simple quantitative research investigated whether patients with cancer developed depression whilst receiving adjuvant chemotherapy, and whether there was a particular time in the treatment cycle that it was likely to develop. A longitudinal survey method was chosen and the instrument of use was the Beck Depression Inventory II (BDI-II). The content of this survey include factors that reflect negative attitudes towards self, performance impairment and somatic disturbances as well as general factors of depression. Twenty-six participants were given the BDI-II, and asked to report on side effects that they had experienced every two weeks whilst they were receiving chemotherapy. The study took place in two regional oncology clinics. This report demonstrates that, patients can develop depression whilst receiving adjuvant chemotherapy. The study revealed that the 5th fortnight into a patient’s chemotherapy treatment was a more vulnerable point in their treatment to develop depression. Descriptive analysis illustrated that more females than males suffered depression and that those receiving treatment for breast cancer were more likely to develop depression. Correlation statistics demonstrated a relationship between fatigue and depressive symptoms. There was no statistically significant correlation between the number of side effects experienced by participants and depression. In summary, the findings suggest that patients were more vulnerable to developing depression around the 5th fortnight of their chemotherapy cycle. This research has demonstrated throughout that depression does occur in patients receiving adjuvant chemotherapy and that female patients are more likely to develop depression than males. Due to the small sample size though, the results were not statistically significant. The findings from this research could provide direction for more thorough studies in the future. The style of reporting used throughout this thesis has been the Harvard referencing style to ensure compliance with the university requirements and to maintain consistency.
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Molenaar, Jacobus. "Treatment decision support for early breast cancer patients." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/77496.
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Kantor, Debra P. "Factors Influencing Psychological Distress in Patients with Cancer." Thesis, Adelphi University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3571079.
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Over 40% of Americans are at risk for developing cancer during their lifetime. Technological advances have resulted in improved survival rates. The uncertainty associated with the diagnosis of cancer may give rise to psychological distress. Psychological distress is a multifaceted, complex concept that has shown to interfere with the patient's quality of life, treatment regimens, and treatment outcomes. The purpose of this study was to explore the factors that influence psychological distress in patients with cancer. Influencing factors of psychological distress include medical treatments, personal concerns, family relationships, social support, spirituality, uncertainty and professional support. The theoretical framework that guided this study was derived from the Theory of Uncertainty, Chaos Theory, and review of the literature. The sample consisted of 150 patients diagnosed with non-metastatic cancer living in the suburbs of a major Northeastern United States city. Data was collected using three instruments that measured the degree of psychological distress and the influencing factors: the Distress Thermometer, Mishel's Uncertainty Scale and the Distress Inventory for Cancer-Version 2. The results of this study revealed that significant relationships exist between psychological distress and personal concerns, finances, and uncertainty. In this study the influencing factor of personal concerns was shown to mediate the other factors. Studies have shown that nurses do not routinely screen for psychological distress. Nurses involved in the care of oncology patients can utilize the results of this study to recognize the impact of cancer beyond the clinical manifestations. In addition, nurses can use the results to develop a collaborative plan of care to address the psychological distress that patients with cancer may be experiencing.
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Haseen, Farhana. "Nutritional factors and lifestyle in prostate cancer patients." Thesis, Queen's University Belfast, 2011. https://kclpure.kcl.ac.uk/portal/en/theses/nutritional-factors-and-lifestyle-in-prostate-cancer-patients(3e845f58-4e1b-4f5c-a5cc-605d084b9868).html.
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Prostate cancer is the most common male cancer in the UK. A healthy diet and lifestyle may have the potential to impact upon cancer progression, treatment related side effects, and comorbidities as well as on quality of life in prostate cancer patients. Nutrition and lifestyle behaviours are therefore important aspects to consider in the treatment of prostate cancer patients. The broad aims of this thesis were to explore the importance of health behaviours in prostate cancer patients and to identify and test a suitable intervention specifically for those who are treated with androgen deprivation therapy (ADT). To achieve these aims this thesis has documented the findings of the following studies investigating nutritional and life-style behaviours in prostate cancer patients. 1) Using the cross-sectional population-based data from California Health Interview Survey (CHIS), diet and health behaviours in men with prostate cancer were compared to men with cancer other than prostate and to non-cancer controls. No differences were noted between prostate cancer patients and controls with respect to their dietary intake and physical activity levels. 2) A systematic review was conducted to determine the effects of ADT on body composition in prostate cancer patients. Significant increases in fat and declines in lean mass were observed in prostate cancer patients treated with ADT. 3) A systematic review of the literature related to lycopene intake and prostate cancer progression suggested that evidence available to date was insufficient to draw any firm conclusions regarding the benefits of lycopene supplementation in prostate cancer patients. 4) Preliminary analysis of a RCT of a 6-month dietary and physical activity intervention in prostate cancer patients treated with ADT showed that the intervention group had significant improvements in their body composition compared with controls. Physical activity, functional capacity and dietary quality also improved in the intervention group compared with controls. Recruitment to this trial is ongoing.