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Journal articles on the topic 'Cancer ratio'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Atchyuta, M., I. V. Renuka, P. Premalatha, PAV Krishnamacharyulu, Chitturi Ramya, and U. Pravallika. "Lymphnodal Ratio in Prognostication of Stage III Colon Cancer." Indian Journal of Pathology: Research and Practice 8, no. 2 (2019): 153–58. http://dx.doi.org/10.21088/ijprp.2278.148x.8219.4.

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Verma, Akash, Rucha S. Dagaonkar, Dominic Marshall, John Abisheganaden, and R. W. Light. "Differentiating Malignant from Tubercular Pleural Effusion by Cancer Ratio Plus (Cancer Ratio: Pleural Lymphocyte Count)." Canadian Respiratory Journal 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/7348239.

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Background. We performed prospective validation of the cancer ratio (serum LDH : pleural ADA ratio), previously reported as predictive of malignant effusion retrospectively, and assessed the effect of combining it with “pleural lymphocyte count” in diagnosing malignant pleural effusion (MPE).Methods. Prospective cohort study of patients hospitalized with lymphocyte predominant exudative pleural effusion in 2015.Results. 118 patients, 84 (71.2%) having MPE and 34 (28.8%) having tuberculous pleural effusion (TPE), were analysed. In multivariate logistic regression analysis, cancer ratio, serum L

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Eruku, Dr Baburao. "Differentiating malignant effusions from other exudative effusions by cancer ratio and cancer ratio plus." International Journal of Advanced Research in Medicine 3, no. 2 (2021): 525–29. http://dx.doi.org/10.22271/27069567.2021.v3.i2h.453.

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Ellis, Libby, Aurélien Belot, Bernard Rachet, and Michel P. Coleman. "The Mortality-to-Incidence Ratio Is Not a Valid Proxy for Cancer Survival." Journal of Global Oncology, no. 5 (December 2019): 1–9. http://dx.doi.org/10.1200/jgo.19.00038.

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PURPOSE The ratio of cancer mortality and cancer incidence rates in a population has conventionally been used as an indicator of the completeness of cancer registration. More recently, the complement of the mortality-to-incidence ratio (1-M/I) has increasingly been presented as a surrogate for cancer survival. We discuss why this is mistaken in principle and misleading in practice. METHODS We provide an empirical assessment of the extent to which trends in the 1-M/I ratio reflect trends in cancer survival. We used national cancer incidence, mortality and survival data in England to compare tre

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Abhinav, Manish, Garg Nita, and Sharma Narotam. "Serum CA125, CEA, CA125/CEA ratio and LDH levels in Ovarian Cancer." Indian Journal of Genetics and Molecular Research 7, no. 1 (2018): 17–20. http://dx.doi.org/10.21088/ijgmr.2319.4782.7118.3.

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Fujisawa, Daisuke, Shino Umezawa, Maiko Fujimori, and Mitsunori Miyashita. "Prevalence and associated factors of perceived cancer-related stigma in Japanese cancer survivors." Japanese Journal of Clinical Oncology 50, no. 11 (2020): 1325–29. http://dx.doi.org/10.1093/jjco/hyaa135.

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Abstract This study aimed to examine the prevalence and associated factors of perceived cancer-related stigma among Japanese cancer survivors. In this web-based survey involving 628 Japanese cancer survivors, perceived cancer-related stigma, quality of life (Quality of Life-Cancer Survivors Instrument), psychological distress (K6) and perceived social support (multidimensional scale of perceived social support) were evaluated. Perceived cancer-related stigma was endorsed by 61.2% of the participants. Perceived cancer-related stigma was significantly associated with quality of life (R = 0.35–0.

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P. G., Naveen, and K. Veena L. Karanth. "Derived neutrophil by lymphocytes ratio is a misnomer, implication of derived leucocytes ratio in diagnosing gastric cancers." International Surgery Journal 6, no. 1 (2018): 82. http://dx.doi.org/10.18203/2349-2902.isj20185187.

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Background: Gastric malignant neoplasms are well-known common malignant disease seen in routine clinical practice. In India incidence are comparatively low but accounts for significant mortality and morbidity. Gastric malignancy incidence adds significant numbers every year to cancer related deaths worldwide. And prognosis is not satisfactory in spite of medical innovations and technological advancements. Early diagnosis helps for successful surgical removal of gastric cancer and to achieve a curative resections. Present study objectives are to solve the paradox of misnomer derived neutrophil

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Kim, Sunsuk, Moon Kyung Joo, Jong-Jae Park, et al. "Neutrophil-to-lymphocyte ratio to predict metachronous cancer after curative resection of early gastric cancer." Journal of Clinical Oncology 42, no. 3_suppl (2024): 313. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.313.

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313 Background: We investigate the predictive value of inflammatory markers for occurrence of metachronous cancers among patients who underwent endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) and are judged as curative resection (CR). Methods: We enrolled patients who were diagnosed as EGC and underwent ESD during 2006 and 2020. We retrospective collected data of inflammatory indexes such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and erythrocyte sediment ratio (ESR). Results: A total of 1,011 patients underwent ESD for EGC, achieved CR an

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Gawiński, Cieszymierz, Andrzej Mróz, Katarzyna Roszkowska-Purska, et al. "A Prospective Study on the Roles of the Lymphocyte-to-Monocyte Ratio (LMR), Neutrophil-to-Lymphocyte Ratio (NLR), and Platelet-to-Lymphocyte Ratio (PLR) in Patients with Locally Advanced Rectal Cancer." Biomedicines 11, no. 11 (2023): 3048. http://dx.doi.org/10.3390/biomedicines11113048.

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Rectal cancer constitutes over one-third of all colorectal cancers (CRCs) and is one of the leading causes of cancer-related deaths in developed countries. In order to identify high-risk patients and better adjust therapies, new markers are needed. Systemic inflammatory response (SIR) markers such as LMR, NLR, and PLR have proven to be highly prognostic in many malignancies, including CRC; however, their roles in locally advanced rectal cancer (LARC) are conflicting and lack proper validation. Sixty well-selected patients with LARC treated at the Maria Sklodowska-Curie National Research Instit

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Yasuda, Koji. "The correlation of neutrophil/lymphocyte ratio and tumor reduction ratio in preoperative chermoradiotherapy for advanced rectal cancer." Journal of Clinical Oncology 32, no. 3_suppl (2014): 633. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.633.

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633 Background: Preoperative chemoradiotherapy (CRT) is widely used for the treatment of advanced lower rectal cancer and is considered to reduce the local recurrence rate and improve the anus preservation rate. However, the tumor reduction effect varies among patients, and thus far, no factor has yet been found to be effective in the prediction of therapeutic efficacy. Recent studies have shown tumor immunity in the tumor microenvironment to be involved in the anti-tumor effect of radiation and anti-cancer drugs. Among these studies, some show that the neutrophil/lymphocyte (NL) ratio in bloo

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International, Journal of Medical Science and Innovative Research (IJMSIR). "A Cross Sectional Study to Determine The Efficacy of Serum LDH: Pleural Fluid Ada Ratio As A Biomarker of Malignant Pleural Effusion in IRD, SMS Medical College, Jaipur." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 4 (2024): 151–58. https://doi.org/10.5281/zenodo.15422923.

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<strong>Abstract</strong> <strong>Introduction</strong>: The malignant pleural effusion is one of the most common causes of exudative pleural effusion. There is no accurate and commonly accepted biochemical marker of MPE, hence using common parameters two ratio serum LDH: pleural fluid ADA (cancer ratio) and cancer ratio: pleural fluid lymphocyte count (cancer ratio plus) derived and their efficacy in identification of MPE is studied. <strong>Methods</strong>: 60 undiagnosed pleural effusion patients were studied in a hospital based cross sectional observational analytical study. The values of

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Yazici, Pinar, Mehmet Mihmanli, Emre Bozkurt, Feyza Ozturk, and Mehmet Uludag. "Which is the best predictor of thyroid cancer: thyrotropin, thyroglobulin or their ratio?" HORMONES 15, no. 2 (2016): 256–63. http://dx.doi.org/10.14310/horm.2002.1677.

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Ari, Aziz, and Feray Gunver. "Comparison of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio in patients with thyroiditis and papillary tumors." Journal of International Medical Research 47, no. 5 (2019): 2077–83. http://dx.doi.org/10.1177/0300060519838392.

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Objective The neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) have recently been introduced as prognostic markers of thyroid cancer and strong inflammatory markers. The study was performed to investigate the association of the PLR and NLR with thyroid inflammation and papillary cancer. Methods Patients with thyroiditis and patients with papillary carcinomas were compared with sex-, age-, and body mass index-matched healthy controls. The NLR and PLR were calculated and compared among the three groups. Results The NLR was significantly higher in patients with thyroiditis an

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Gawiński, Cieszymierz, Anna Hołdakowska, and Lucjan Wyrwicz. "Correlation between Lymphocyte-to-Monocyte Ratio (LMR), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR) and Extramural Vascular Invasion (EMVI) in Locally Advanced Rectal Cancer." Current Oncology 30, no. 1 (2022): 545–58. http://dx.doi.org/10.3390/curroncol30010043.

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Rectal cancer constitutes around one-third of all colorectal cancers. New markers are required to optimize the treatment. Extramural vascular invasion (EMVI) is a magnetic resonance imaging (MRI)-based negative prognostic marker. Lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR) are blood-based systemic inflammatory response markers with proven prognostic value in many cancers, including CRC. We hypothesized whether there is a relationship between LMR, NLR, PLR and the presence of EMVI on pre-treatment MRI in patients with locally ad

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Rosa, Fausto, Antonio Pio Tortorelli, Sergio Alfieri, and Giovanni Battista Doglietto. "Lymph Node Ratio for Gastric Cancer." Annals of Surgery 259, no. 4 (2014): e65. http://dx.doi.org/10.1097/sla.0000000000000316.

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Gawiński, Cieszymierz. "Reproducibility of lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with locally advanced rectal cancer." Journal of Clinical Oncology 40, no. 4_suppl (2022): 166. http://dx.doi.org/10.1200/jco.2022.40.4_suppl.166.

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166 Background: Rectal cancer constitutes over one-third of all colorectal cancers (CRC) and is one of the leading cause of cancer-related death in developed countries. Treatment modalities applied in locally advanced tumors differ substantially among research centers. In order to identify high-risk patients and better adjust the therapy new markers are needed. Systemic inflammatory response (SIR) markers such as LMR, NLR and PLR have been proved highly prognostic in many malignancies, including CRC; however, they lack proper validation. In our study we assessed the reproducibility of LMR, NLR

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Wang, Jeanny, Eric Engels, and Minkyo Song. "Abstract 2250: Eosinophil-to-lymphocyte ratio and cancer risk in the UK Biobank." Cancer Research 82, no. 12_Supplement (2022): 2250. http://dx.doi.org/10.1158/1538-7445.am2022-2250.

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Abstract Background: Eosinophils exhibit anti-tumor cytotoxic responses in the tumor microenvironment. Some atopic diseases, characterized by elevated peripheral eosinophils, are inversely associated with cancer risk. The balance of atopy and immunity may be estimated by an eosinophil-to-lymphocyte ratio (ELR). This study aims to understand the role of ELR as a biomarker in carcinogenesis. Methods: We evaluated 445,404 adults aged 37-73 years at baseline in a prospective cohort study, the UK Biobank, who were cancer-free at initial assessment, had more than one year of follow-up, and had basel

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Bahgat, Taha. "Breast cancer prognostication with neutrophil–lymphocyte ratio and platelet–lymphocyte ratio." Al-Azhar Assiut Medical Journal 15, no. 4 (2017): 179. http://dx.doi.org/10.4103/azmj.azmj_45_16.

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López Altamirano, Joselyn Macarena, and Daniela Alexandra Rosero Freire. "Prognostic efficacy of platelet/lymphocyte ratio and neutrophil/lymphocyte ratio in patients with gastric cancer." Salud, Ciencia y Tecnología 3 (January 26, 2023): 232. http://dx.doi.org/10.56294/saludcyt2023232.

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Cancer is the main cause of death before age 70. Gastric cancer (GC) is responsible for 1 in 13 deaths worldwide and is predominant in men. Inflammation is closely related to cancer, as it activates different blood cells such as neutrophils, lymphocytes, platelets, etc. A bibliographic review was carried out to collect and analyze studies concerning the prognostic efficacy of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patients with gastric cancer. Upon analysis, several studies indicated that elevated values of both NLR and PLR show poor prognosis. However, we sug

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FIRAT, Sevde Nur, Işılay TAŞKALDIRAN, Şerife KUŞKONMAZ, and Cavit ÇULHA. "AST/ALT (De Ritis) Ratio in Early Stage Differentiated Thyroid Cancer." Kocaeli Üniversitesi Sağlık Bilimleri Dergisi 8, no. 2 (2022): 125–28. http://dx.doi.org/10.30934/kusbed.1009993.

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Objective: Differentiated thyroid cancers are the most common endocrine cancers and their frequency is increasing with the increase in imaging possibilities. In various malignancies; Even in the absence of liver metastases, it was determined that AST value increased compared to ALT due to increased metabolism, tissue damage and rapid tumor turnover. This rate is known as the De Ritis rate, and in our study, we planned to evaluate whether there is a relationship between histopathological subtype, multifocality, disease stage and risk group and AST/ALT (De Ritis) ratio in early stage thyroid can

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Kumarasamy, Chellan, Vaibhav Tiwary, Krishnan Sunil, et al. "Prognostic Utility of Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Monocyte–Lymphocyte Ratio in Head and Neck Cancers: A Detailed PRISMA Compliant Systematic Review and Meta-Analysis." Cancers 13, no. 16 (2021): 4166. http://dx.doi.org/10.3390/cancers13164166.

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Inflammation plays a major role in cancer development and progression and has the potential to be used as a prognostic marker in cancer. Previous studies have attempted to evaluate Platelet-to-lymphocyte ratio (PLR), neutrophil–lymphocyte ratio (NLR) or monocyte–lymphocyte ratio (MLR) as indicators of inflammation/prognostic markers in cancer, but there is no common consensus on their application in clinical practice. The aim of this systematic review and meta-analysis is to (a) assess the prognostic efficacy of all three prognostic markers in comparison to each other and (b) investigate the p

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Wiranata, Sinta, Ida Ayu Widya Anjani, I. Putu Gede Septiawan Saputra, et al. "Pretreatment Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as a Stage Determination in Breast Cancer." Open Access Macedonian Journal of Medical Sciences 8, B (2020): 1058–63. http://dx.doi.org/10.3889/oamjms.2020.5336.

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BACKGROUND: Breast cancer tends to respond differently to treatments, which are usually determined by clinicopathological characteristics. Several studies evaluated the role of the peripheral blood test as diagnostic and prognostic markers in several types of solid cancer and neutrophil-to-lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR) are two of them which already tested. However, the evidence in breast cancer is still lacking.  AIM: Therefore, the study aimed to investigate the value of NLR and PLR as biomarkers concerning breast cancer stage. METHODS: A retrospecti

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Budiana, Budian, Bayu Mahendra, Putra Wiradnyana, Darmayasa Darmayasa, Fajar Marta, and Suwanpramana Suwanpramana. "C-Reactive Protein/Albumin (Crp/Alb) Ratio as a Predictor of Ovarian Cancer." Jurnal Health Sains 4, no. 5 (2023): 79–90. http://dx.doi.org/10.46799/jhs.v4i5.913.

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Ovarian cancer is a type of cancer with a high incidence and mortality rate in Indonesia and worldwide. C-reactive protein (CRP) is an inflammatory marker meanwhile albumin is an indicator of nutritional deficiencies in ovarian cancer. This study is a diagnostic test for ovarian cancer in women aged >18 years and without previous history of ovarian cancer who underwent laparotomy or laparoscopy at Prof. Ngoerah General Hospital, Denpasar. Samples were taken by consecutive sampling. CRP examination was carried out in the laboratory by immunoturbidimetry method using the CRP Latex Kit (Roche)

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Ecin, Seval Müzeyyen, and Deniz Gezer. "Evaluation of the clinical and prognostic importance of infection parameters in thyroid cancers: A cross-sectional study." Medicine 102, no. 49 (2023): e36532. http://dx.doi.org/10.1097/md.0000000000036532.

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Thyroid cancers are among the most common endocrine cancers. An inflammation is associated with many stages of cancer. Therefore, in this study, we aimed to evaluate whether it has a prognostic significance inflammation marker. Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio, systemic inflammation response, systemic immune-inflammation index, and neutrophils to lymphocytes and platelets ratio (N/LP) in patients diagnosed with thyroid cancer in the internal medicine outpatient clinic and operated between March 1, 2017 and May 1, 2022 were evaluated retrospectiv

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Subhankar Saren, Animesh Mandal, Amit Kumar Das, Ranjit Kumar Haldar, and Sudipta Pandit. "Identifying malignant pleural effusion from tubercular pleural effusion by study of cancer ratio and cancer ratio plus." Asian Journal of Medical Sciences 16, no. 2 (2025): 97–102. https://doi.org/10.71152/ajms.v16i2.4323.

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Background: Early detection of malignant pleural effusions (MPE) through routine biochemical tests will go a long way in improving morbidity and mortality of these patients. Aims and Objectives: The current study was aimed to observe the usefulness of cancer ratio (CR) and CR plus to diagnose malignant effusions early in disease evolution. Materials and Methods: The study was a cross-sectional comparative observational study conducted at the indoor and outdoor facility of Respiratory Medicine department of Institute of Post Graduate Medical Education and Research, Kolkata. Results: Sixty-one p

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Asif, Aqua, Vinson Wai-Shun Chan, Filzah Hanis Osman, et al. "The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Small Renal Cell Carcinomas after Image-Guided Cryoablation or Radio-Frequency Ablation." Cancers 15, no. 7 (2023): 2187. http://dx.doi.org/10.3390/cancers15072187.

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There is a lack of cheap and effective biomarkers for the prediction of renal cancer outcomes post-image-guided ablation. This is a retrospective study of patients with localised small renal cell cancer (T1a or T1b) undergoing cryoablation or radiofrequency ablation (RFA) at our institution from 2003 to 2016. A total of 203 patients were included in the analysis. In the multivariable analysis, patients with raised neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) pre-operatively, post-operatively and peri-operatively are associated with significantly worsened cancer-s

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Zhang, Yu, Le Wang, Yunduo Liu, et al. "Preoperative Neutrophil-Lymphocyte Ratio Before Platelet-Lymphocyte Ratio Predicts Clinical Outcome in Patients With Cervical Cancer Treated With Initial Radical Surgery." International Journal of Gynecologic Cancer 24, no. 7 (2014): 1319–25. http://dx.doi.org/10.1097/igc.0000000000000219.

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ObjectiveSeveral inflammatory parameters are applied to predict the survival of patients with various cancers. Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are 2 nonspecific markers of systemic inflammation. This study aimed to evaluate the clinicopathologic and prognostic values of NLR and PLR in patients with cervical cancer undergoing primary radical hysterectomy with pelvic lymphadenectomy.MethodsA total of 460 cervical cancer patients were enrolled in this study. These patients were histologically confirmed with cervical cancer from February 2005 to June 2008, at

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Turchan, William Tyler, Sean P. Pitroda, and Ralph R. Weichselbaum. "Combined radio-immunotherapy: An opportunity to increase the therapeutic ratio of oligometastasis-directed radiotherapy." Neoplasia 27 (May 2022): 100782. http://dx.doi.org/10.1016/j.neo.2022.100782.

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Gupta, Dr Ashumi, Dr Urvashi Singh, Dr Mohan Lal Gupta, Dr Narendra Mogra, and Dr Medha Mathur. "Significance of neutrophil lymphocyte ratio and platelet lymphocyte ratio in lung cancer." Tropical Journal of Pathology and Microbiology 5, no. 11 (2019): 872–77. http://dx.doi.org/10.17511/jopm.2019.i11.07.

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Kartolo, Adi, Ryan Holstead, Sidra Khalid, et al. "Serum neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in prognosticating immunotherapy efficacy." Immunotherapy 12, no. 11 (2020): 785–98. http://dx.doi.org/10.2217/imt-2020-0105.

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Aim: To examine neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in prognosticating immunotherapy efficacy. Methods: A retrospective study of 156 patients with metastatic melanoma and non-small-cell lung cancer on PD-1 inhibitors. Results: Baseline NLR ≥5 was associated with worse progression-free survival (hazard ratio [HR]: 1.53; 95% CI: 1.01–2.31; p = 0.043) but nonsignificant worse overall survival trend (HR: 1.51; 95% CI: 0.98–2.34; p = 0.064). PLR ≥200 was associated with worse overall survival (HR: 1.94; 95% CI: 1.29–2.94; p = 0.002) and worse progression-free

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Beyhan Sagmen, Seda, Coskun Dogan, Sevda Comert, Nesrin Kiral, Ali Fidan, and Elif Torun Parmaksiz. "Prognostic Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Lung Cancer." Medical Laboratory Technology Journal 5, no. 1 (2019): 32. http://dx.doi.org/10.31964/mltj.v5i1.211.

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Numerous studies determined that the neutrophil/lymphocyte (NLR) and platelet/lymphocyte ratios (PLR) had prognostic value in several cancer types. This study aimed to evaluate the relationship between NLR and PLR values with the survival time of lung cancer patients. Patients diagnosed with lung cancer between January 2014 and December 2016, were retrospectively evaluated. Demographic characteristics, disease stages, laboratory parameters recorded, and the relationship of NLR and PLR values with the survival time and the disease stage evaluated. NLR and PLR were categorized into two groups. S

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Lee, Yen-Chien, Yen-Ling Lee, and Chung-Yi Li. "BRCA Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies." Medicina 57, no. 9 (2021): 905. http://dx.doi.org/10.3390/medicina57090905.

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Background and Objectives:BRCA1 and BRCA2 are genes located in different chromosomes that are disproportionately associated with hereditary breast and ovarian cancer syndrome. Their association with other cancers remains to be explored. Materials and Methods: We systematically reviewed cohort studies to explore the association of BRCA 1 and BRCA2 with various cancers except lung cancer. We searched PubMed, Medline (EBSCOhost) and relevant articles published up to 10 May 2021. The odds ratio, standardised morbidity rate and cancer-specific standardised incidence ratio were pooled together as re

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Tran, Thi-Van-Trinh, Cari M. Kitahara, Florent de Vathaire, Marie-Christine Boutron-Ruault, and Neige Journy. "Thyroid dysfunction and cancer incidence: a systematic review and meta-analysis." Endocrine-Related Cancer 27, no. 4 (2020): 245–59. http://dx.doi.org/10.1530/erc-19-0417.

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In this study, we aimed to evaluate site-specific cancer risks associated with hyperthyroidism or hypothyroidism. We performed a systematic review of observational studies reporting associations between hyperthyroidism or hypothyroidism and subsequent site-specific cancer incidence, in MEDLINE and the COCHRANE library (inception-28/01/2019) (PROSPERO: CRD42019125094). We excluded studies with thyroid dysfunction evaluated as a cancer biomarker or after prior cancer diagnosis and those considering transient thyroid dysfunction during pregnancy or severe illnesses. Risk of bias was assessed usin

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Nguyen, Mai Ly Thi, Chi Pham, Quoc Vuong Le, et al. "The diagnostic and prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio on gastric cancer patients." Medicine 102, no. 31 (2023): e34357. http://dx.doi.org/10.1097/md.0000000000034357.

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Gastric cancer (GC) is the remaining concern of cancer-associated health burden. Valuable predictive and prognostic indicators support the early diagnosis and improve outcome. Immune escape and inflammation are important cancer hallmarks. The prognostic and diagnostic value of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) was reported in some cancers. But these cheap and convenient indexes are far from clinical use. Thus, investigation the alteration of those index on GC is needed to impose the use of those indexes in clinic. The study recruited seventy-seven hosp

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Athanasiou, Antonios, Michael Spartalis, and Eleftherios Spartalis. "Platelets-to-lymphocyte ratio and esophageal cancer." Journal of Thoracic Disease 10, no. 8 (2018): E650—E651. http://dx.doi.org/10.21037/jtd.2018.07.41.

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Vergote, Ignace B., Peter A. van Dam, Gert M. Laekeman, Guy H. Keersmaeckers, Frans L. Uyttenbroeck, and Arnold G. Herman. "Prostacyclin/Thromboxane Ratio in Human Breast Cancer." Tumor Biology 12, no. 5 (1991): 261–66. http://dx.doi.org/10.1159/000217713.

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Clifford, Gary M., Mauro Lise, Silvia Franceschi, and Alexandra U. Scherrer. "CD4/CD8 ratio and lung cancer risk." Lancet HIV 4, no. 3 (2017): e103. http://dx.doi.org/10.1016/s2352-3018(17)30027-9.

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Raza, Syed Ahsan, Ramzan tahir, Mirelle Schnitzer, and Jack Siemiatycki. "Worldwide Sex Ratio Variations in Cancer Incidence." Annals of Epidemiology 27, no. 8 (2017): 507–8. http://dx.doi.org/10.1016/j.annepidem.2017.07.113.

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Ong, Hui Shan, Sandhya Gokavarapu, Li Zhen Wang, Zhen Tian, and Chen Ping Zhang. "Low Pretreatment Lymphocyte-Monocyte Ratio and High Platelet-Lymphocyte Ratio Indicate Poor Cancer Outcome in Early Tongue Cancer." Journal of Oral and Maxillofacial Surgery 75, no. 8 (2017): 1762–74. http://dx.doi.org/10.1016/j.joms.2016.12.023.

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Matuszczak, Milena, Adam Kiljańczyk, Wojciech Marciniak, et al. "Antioxidant Properties of Zinc and Copper—Blood Zinc-to Copper-Ratio as a Marker of Cancer Risk BRCA1 Mutation Carriers." Antioxidants 13, no. 7 (2024): 841. http://dx.doi.org/10.3390/antiox13070841.

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Pathogenic mutations in BRCA1 (BReast CAncer gene 1) confer high risks of both breast (up to 70%) and ovarian (up to 40%) cancers. Zinc (Zn) and copper (Cu) are essential for various physiological functions, including antioxidant reactions. Their balance, reflected in the Zn/Cu ratio, plays a crucial role in maintaining redox homeostasis, which is vital for cancer prevention. This study examines the antioxidant properties of Zn and Cu, specifically focusing on the blood Zn/Cu ratio as a potential marker for cancer risk among BRCA1 mutation carriers. The study cohort consisted of 989 initially

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Mosalem, Osama, Saud Alsubait, Shouq Kherallah, et al. "Impact of pre-treatment lymphocyte monocyte ratio and neutrophil lymphocyte ratio on pathologic response in breast cancer patients receiving neoadjuvant chemotherapy." Journal of Clinical Oncology 39, no. 15_suppl (2021): e12623-e12623. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e12623.

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e12623 Background: Hematologic markers have been looked at as potential prognostic biomarkers in a variety of cancers. Ni and colleagues (2014) have shown that an elevated pre-treatment lymphocyte-to-monocyte ratio (LMR) was significantly associated with improved disease-free survival (DFS) in patients with locally advanced breast cancer receiving neoadjuvant chemotherapy (NACT). Given the prognostic implications of hematologic inflammatory parameters, we sought to understand if such biomarkers will predict response to neoadjuvant chemotherapy (NACT) in patients with breast cancer. Methods: We

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Zhu, Xuming, Huizhu Song, Yan Chen, Feifei Han, Qiong Wang, and Yubao Cui. "Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Blood to Distinguish Lung Cancer Patients from Healthy Subjects." Disease Markers 2020 (October 16, 2020): 1–5. http://dx.doi.org/10.1155/2020/8844698.

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Objective. Inflammation-driven markers play a crucial role in tumorigenesis and tumor progression. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in blood are systemic inflammatory response markers. Some reports have showed that NLR and PLR are related to a poor prognosis in patients with lung cancer. However, little studies have reported whether NLR and PLR can be diagnostic markers for lung cancer. The aim of the current study is to investigate the roles of NLR and PLR in diagnosing lung cancer. Methods. This study analyzed data from lung cancer patients and

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Pyo, Jung-Soo, Young-Min Shin, and Dong-Wook Kang. "Prognostic Implication of Metastatic Lymph Node Ratio in Colorectal Cancers: Comparison Depending on Tumor Location." Journal of Clinical Medicine 8, no. 11 (2019): 1812. http://dx.doi.org/10.3390/jcm8111812.

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Background: The proportion of the number of involved lymph nodes (LNs) to the number of examined LNs—defined as metastatic LN ratio (mLNR)—has been considered as a prognostic parameter. This study aims to elucidate the prognostic implication of the mLNR in colorectal cancer (CRC) according to the tumor location. Methods: We evaluated the correlation between prognoses and the involved and examined LNs as well as mLNR according to the tumor location in 266 surgically resected human CRCs. Besides, to evaluate the optimal cutoff for high and low mLNRs, we investigated the correlation between mLNR

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Gawiński, Cieszymierz, Mariola Winiarek, Sebastian Rybski, Maciej Temnyk, Katarzyna Kokoszyńska, and Lucjan Wyrwicz. "Reproducibility of pretreatment lymphocyte-to-monocyte ratio (LMR) in rectal cancer." Journal of Clinical Oncology 36, no. 4_suppl (2018): 715. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.715.

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715 Background: Lymphocyte-to-monocyte ratio (LMR) is a strong prognostic factor in many cancers. Recently, in Polish-2 study it was demonstrated to have a predictive value for hypofractionated neoadjuvant radiotherapy in rectal cancer (WCGIC 2017). LMR > 2.6 was associated with significant improvement of overall survival after short-course radiotherapy (5x5 Gy) and consolidating chemotherapy when compared to chemoradiotherapy (HR 0.36). To our knowledge this is the first observation on use of a predictive biomarker for hypofractionated radiotherapy. In this study we assessed the intra-pati

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Ming, Xinliang, Shili Qiu, Xuefang Liu, et al. "Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis." Technology in Cancer Research & Treatment 18 (January 1, 2019): 153303381882110. http://dx.doi.org/10.1177/1533033818821106.

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Background: The prognostic value of tenascin-C in different types of cancers remains controversial. To clarify its prognostic value on overall survival rates, we have conducted a meta-analysis to quantitatively assess the prognostic roles of tenascin-C for patients with cancer. Methods: We systematically searched all published studies about the role of tenascin-C in cancers on PubMed, Web of Science, Cochrane Library, and Embase. The pooled hazard ratio with 95% confidence intervals was used to analyze the association between tenascin-C expression level and overall survival of patients with ca

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Mezzanotte, Guerrino, Cesare Cislaghi, Adriano Decarli, and Carlo La Vecchia. "Cancer Mortality in Broad Italian Geographical Areas, 1975-1977." Tumori Journal 72, no. 2 (1986): 145–52. http://dx.doi.org/10.1177/030089168607200205.

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Death certification rates from various cancers or groups of cancers in broad Italian geographical areas (North/Center/South) over the period 1975-1977 were analyzed. In both sexes, there was a clear North/South gradient, with considerably higher rates in the North for total cancer mortality as well as for most common neoplasms. The geographical variation was more marked in males (North/South ratio for total cancer mortality = 1.75 at all ages and 1.70 truncated 35-64 years) than in females (ratio = 1.48 at all ages and 1.28 truncated 35-64). Although, in general terms, the present results conf

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Lee, Suee, Sung Yong Oh, Hyuk-Chan Kwon, et al. "The clinical significance of neutrophil-lymphocyte ratio versus platelet-lymphocyte ratio in patients with metastatic gastric cancer." Journal of Clinical Oncology 30, no. 15_suppl (2012): e14686-e14686. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e14686.

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e14686 Background: Several inflammatory response materials could be biomarkers for prediction of prognosis of cancer patients. The neutrophil/lymphocyte ratio (NLR), and the platelet/lymphocyte ratio (PLR) has been introduced for prognostic scoring system in several cancer. The objective of this study was to determine whether the neutrophil-lymphocyte ratio (NLR), or the platelet-lymphocyte ratio (PLR) are significant prognostic marker in metastatic gastric cancer. Methods: We analyzed 150 patients with metastatic gastric cancer who received mFOLFOX regimen as the first-line chemotherapy. The

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Goldacre, Michael J., Lianne M. Kurina, Clare J. Wotton, David Yeates, and Valerie Seagroatt. "Schizophrenia and cancer: an epidemiological study." British Journal of Psychiatry 187, no. 4 (2005): 334–38. http://dx.doi.org/10.1192/bjp.187.4.334.

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BackgroundFor decades there has been interest in the possibility that people with schizophrenia might have some protection against cancer, and that, if this were so, it might hold clues about aetiological mechanisms in schizophrenia.AimsTo study cancer incidence in schizophrenia.MethodCohort analysis of linked hospital and death records was used to compare cancer rates in people with schizophrenia with a reference cohort.ResultsWe did not find a reduced risk for cancer overall (rate ratio 0.99, 95% CI 0.90–1.08) or for most individual cancers. There was, however, a significantly low rate ratio

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Hechter, Sharon, Ivan Nikiforov, and David B. Greenberg. "Gastrointestinal cancer trends in the Hispanic population: A SEER database population study (2000-2019)." Journal of Clinical Oncology 41, no. 16_suppl (2023): e16331-e16331. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e16331.

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e16331 Background: Cancer continues to be the leading cause of death in the Hispanic population. Gastrointestinal cancer surveillance data in Hispanic individuals has only recently become available in the last 3 decades. Differences in incidence rates among Hispanics and Non-Hispanic Whites (NHWs) need further elucidation. In this study, we analyzed trends in Hispanics and NHW populations across multiple gastrointestinal cancers. Methods: Gastrointestinal cancers (liver, colon and rectum, pancreas, esophagus, gallbladder, stomach, small intestine, anus, anal canal and anorectum) diagnosed betw

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Hechter, Sharon, Ivan Nikiforov, and David B. Greenberg. "Gastrointestinal cancer trends in the Hispanic population: A SEER database population study (2000-2019)." Journal of Clinical Oncology 42, no. 3_suppl (2024): 725. http://dx.doi.org/10.1200/jco.2024.42.3_suppl.725.

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725 Background: Cancer continues to be the leading cause of death in the Hispanic population. Gastrointestinal cancer surveillance data in Hispanic individuals has only recently become available in the last 3 decades. Differences in incidence rates among Hispanics and Non-Hispanic Whites (NHWs) need further elucidation. In this study, we analyzed trends in Hispanics and NHW populations across multiple gastrointestinal cancers. Methods: Gastrointestinal cancers (liver, colon and rectum, pancreas, esophagus, gallbladder, stomach, small intestine, anus, anal canal and anorectum) diagnosed between

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