Relevant bibliographies by topics / Cancer Research Center of Hawaii

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Academic literature on the topic 'Cancer Research Center of Hawaii'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Cancer Research Center of Hawaii"

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Fukui, Jami Aya, Shirley Cheng, Shannon Lim, John Shepherd, Paulette Yamada, and Cheri Teranishi-Hashimoto. "The effect of longitudinal exercise programming in breast cancer patients." Journal of Clinical Oncology 38, no. 15_suppl (2020): TPS12124. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.tps12124.

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TPS12124 Background: Obesity and weight gain are significant concerns for breast cancer survivors. Obesity at diagnosis is an established negative prognostic factor and studies suggest that post-diagnosis weight gain may increase risk for recurrence and decrease disease free survival. Various interventions such as dietary modification, physical activity, individualized counseling, cognitive behavioral therapy, and combinations of these interventions have been studied in order to identify strategies for weight loss in breast cancer survivors. However, one of the main challenges have been to show sustainability in these interventions. Given the adverse consequences of weight gain after diagnosis, continued efforts to identify appropriate weight management interventions aimed at promoting overall health and long term survivorship are needed. Methods: We have opened an investigator initiated Breast Cancer Exercise Study that provides a tailored exercise program and body health assessments for breast cancer patients along their treatment journey. We are enrolling women diagnosed with breast cancer up to 2 years after their diagnosis into a two 12-week exercise program. Participants’ biometrics and physical assessments will be assessed at baseline to determine the appropriate exercise intensity to implement. Women will attend private 1:1, 90min sessions, 3 days/week. At the end of the initial 12-week program, biometric assessments are again performed and participants are then randomized to either: a) continue with individual exercise classes, 2 days/week or b) continue with group exercise classes, 2 days/week. The study follows their long term outcomes including cancer recurrence, exercise adherence as well as quality of life symptoms. The functional health assessment and subsequent personalized exercise program utilizes kinesiology students from University of Hawaii-Manoa during their clinical practicum and is based at our community partner facility the Rehabilitation Hospital of the Pacific. Body assessments and other biomarkers are evaluated through expertise at University of Hawaii Cancer Center. Collectively, our study exemplifies our partnership with community facilities, utilizes cutting edge research and incorporates local students, to provide an important health program for cancer patients all the while enriching our understanding of the unique patient population. The results of this project may help to develop standardized exercise protocols for breast cancer survivors and provide insights to other important health concerns. Clinical trial information: NCT04013568 .
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Palafox, N., R. Leon Guerrero, H. Robinett, J. Peterson, D. Ward, and C. W. Vogel. "Advancing Cancer Health Equity in Pacific Islanders: A 15-Year Investment in Cancer Research, Training and Outreach in Guam, Hawaii and the U.S. Associated Pacific Islands." Journal of Global Oncology 4, Supplement 2 (2018): 17s. http://dx.doi.org/10.1200/jgo.18.32100.

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Background: Pacific Islanders (PI) in Guam (GU), Hawaii (HI), and the U.S. associated Pacific Islands (USAPI) experience greater cancer health disparities compared with majority populations in GU, HI, and the U.S. continent. Social determinants including geographic, socio-cultural, and economic factors are barriers to health and health care, leading to late stage diagnosis and poor survival outcomes. PIs are also highly underrepresented among cancer researchers. Aim: The University of Guam (UOG)/University of Hawaii Cancer Center (UHCC) partnership aims to grow cancer research capacity at UOG, develop cancer health disparities research at UHCC focusing on Pacific Islanders (PI), raise awareness of cancer and cancer prevention in GU, HI and the USAPI, and increase the number of cancer and biomedical scientists of PI ancestry in the U.S. Methods: An infrastructure comprised of five principal investigators and approximately 30 participating faculty, administrative staff, and community and scientific advisory members, supported by funds from the National Cancer Institute and the partnering institutions, has provided 15 years of support for cancer research, training, and outreach designed to reduce cancer health disparities and advance health equity among Pacific Islanders in GU, HI and the USAPI. Results: Fifteen collaborative research projects have been funded through the partnership. Many of these projects have focused on the prevention of unhealthy lifestyle behaviors that lead to increased cancer risk. Prepilot, pilot and full research projects address cancer health disparities of regional relevance and global importance, notably breast, cervical and oral cancers as well as tobacco and betel nut use. A betel nut cessation intervention, the first of its kind, shows promising quit rates. This research has resulted in over 80 publications, 100+ abstracts, and 9 grant awards. The partnership has recruited and trained 26 underrepresented graduate scholars in cancer health disparities, including two scholars who have since joined UOG's faculty and are now independently conducting research, participating in the partnership as investigators, and mentoring tomorrow's scientists. UOG faculty and early stage investigators continue to receive mentorship and career development support. Outreach activities have contributed to the introduction and passage of significant cancer prevention and control legislation in Guam and Saipan. Outcomes are communicated through the partnership's Website, social media, and community reports and seminars. Conclusion: The partnership has significantly increased research capacity at UOG and cultivated interest in cancer research among underrepresented minority students at the partnering institutions. A regional research infrastructure has been established, and research findings are informing public health policy and planning. Resources have been leveraged to address PI cancer health disparities in GU, HI, and the USAPI.
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Lee, Yu-Che, Ko-Yun Chang, and Judith Hurley. "Association between breast cancer mortality-to-incidence ratios and state health disparities in the United States." Journal of Clinical Oncology 37, no. 15_suppl (2019): 1548. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.1548.

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1548 Background: Breast cancer is the most commonly diagnosed cancer and second leading cause of cancer deaths among women in the United States. The cancer mortality-to-incidence ratio (MIR) provides a population-based indicator of cancer survival and has been established previously to evaluate healthcare variations among different countries. We aim to evaluate the association, which has not been investigated before, between MIR of breast cancer and state-level health disparities in the United States. Methods: We used United States Cancer Statistics (USCS) database to calculate 6-year average of MIRs for breast cancer from 2010 to 2015. America’s Health Rankings (AHR) is a platform using weighted measures in 5 different categories (Behaviors, Community & Environment, Policy, Clinical Care and Outcomes) to determine annual state health rankings. Six-year average (2010-2015) of health uninsured rate by state was obtained from the U.S. Census Bureau and 5-year average (2010-2014) of health spending per capita by state was obtained from Centers for Medicare & Medicaid Services. The correlations between breast cancer MIRs and state health variables were calculated by linear regression analyses. Results: From 2010 through 2015, 1,390,357 females were diagnosed with breast cancer and 246,671 females died from breast cancer in the United States. The 6-year average of age-adjusted incidence rate, mortality rate and MIRs were 124.2 ± 1.3 per 100,000 population, 21.1 ± 0.6 per 100,000 and 0.170 ± 0.007, respectively. Among fifty states we included for analyses, Hawaii had the lowest MIR (0.116 ± 0.014) and Nevada had the highest MIR (0.204 ± 0.004). AHR showed Hawaii had the highest health ranking (No. 1) whereas Louisiana had the lowest health ranking (No. 50) in 2015. In our analysis, states with better health rankings, lower health uninsured rates and higher health spending per capita were significantly correlated with lower MIRs (R2 = 0.695, 0.453 and 0.253, respectively; all P < 0.001). Conclusions: The difference of MIRs for breast cancer was strongly associated with state health diversities. These findings suggest that MIR of breast cancer can be an applicable measure to evaluate and reflect the state-level health disparities in the United States. [Table: see text]
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Leon Guerrero, Rachael T., Neal A. Palafox, Margaret P. Hattori-Uchima, Hali R. Robinett, and Carl-Wilhelm Vogel. "Addressing Cancer Health Disparities in the Pacific Peoples of Hawai‘i, Guam, and the US Associated Pacific Islands Through Pacific-Focused Research Capacity Building." JCO Global Oncology, no. 6 (September 2020): 155–60. http://dx.doi.org/10.1200/go.19.00213.

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Sociocultural, geographic, and biologic factors contribute to cancer health disparities (CHDs) in Indigenous Pacific peoples (IPPs) in Guam, Hawai‘i, and the US Associated Pacific Islands (USAPI). IPPs experience a greater burden of CHDs that are associated with late-stage diagnosis and poor survival outcomes compared with majority populations in the United States. A 16-year partnership between the University of Guam (UOG) and University of Hawai‘i Cancer Center (UHCC) aims to advance health equity in Guam, Hawai‘i, and the USAPI through cancer research, training, and outreach. Investigators at collaborating institutions study issues of regional and cultural relevance in IPPs, including breast, cervical, liver, and oral cancers and use of tobacco and betel nuts (Areca nuts). Junior faculty with IPP ancestry or those who are focused on CHDs in IPPs receive mentorship and career development opportunities, academic fellowships are provided for graduate students, and Pacific Island communities are engaged through a participatory development process. The partnership has generated more than 90 peer-reviewed publications, more than 100 abstracts, and 11 grant awards. Thirty graduate scholars from under-represented minorities have been trained, including two who are now UOG faculty and are conducting independent research, contributing to the partnership, and mentoring scientists of tomorrow. Participatory community engagement has contributed to the passage of significant cancer prevention and control legislation in Hawai‘i, Guam, and Saipan. Research capacity at UOG has increased significantly, and research at UHCC has expanded to address issues unique to IPPs. Graduate students from under-represented minorities are pursuing careers in cancer research. A regional research infrastructure has been established to support team science, and research findings are informing public health policy and planning.
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Graffunder, Corinne M., Stephen W. Wyatt, Barbara Bewerse, Irene Hall, Barbara Reilley, and Rebeca Lee-Pethel. "Skin Cancer Prevention: The Problem, Responses, and Lessons Learned." Health Education & Behavior 26, no. 3 (1999): 308–16. http://dx.doi.org/10.1177/109019819902600303.

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Skin cancer is one of the most common forms of cancer and has rapidly increased during the past three decades in the United States. More than 1 million new cases of skin cancer are estimated to be diagnosed in the United States each year. The National Skin Cancer Prevention Education Program (NSCPEP) was launched by the Centers for Disease Control and Prevention (CDC) in 1994 as a national effort to address the Healthy People 2000 objectives for skin cancer prevention. The NSCPEP is a comprehensive, multidimensional public health approach that includes (1) primary prevention interventions; (2) coalition and partnership development; (3) health communications and education; and (4) surveillance, research, and evaluation. In 1994, through support from the CDC, state health departments in Arizona, California, Georgia, Hawaii, and Massachusetts initiated primary prevention intervention projects to conduct and evaluate skin cancer prevention education. This article discusses the comprehensive, multidimensional public health approach highlighting examples from the state demonstration projects.
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Cheung, Christabel K., Thuli Katerere-Virima, Laura E. Helbling, Bria N. Thomas, and Reginald Tucker-Seeley. "Capturing the financial hardship of cancer in military adolescent and young adult patients: A conceptual framework." Journal of Clinical Oncology 38, no. 29_suppl (2020): 163. http://dx.doi.org/10.1200/jco.2020.38.29_suppl.163.

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163 Background: Cancer can be a setback for young active-duty military patients, with potential implications for their financial well-being, early career paths, and young families. Despite the assumption of sufficient material support for military patients, cancer and its treatments still result in substantial out-of-pocket expenses and lost-opportunity costs that can lead to financial hardship. Although prior cancer survivorship studies have put forth a material, psychosocial, and behavioral conceptual framework for describing financial hardship following a cancer diagnosis, it is unknown whether this framework adequately depicts the experience of financial hardship among military adolescent and young adult (AYA) patients. The primary aim of the current study was to extend this conceptual model of financial hardship following a cancer diagnosis for application among military AYA patients. Methods: Using Gale and colleagues’ Framework Method for qualitative multi-disciplinary health research, the investigator team conducted focus groups and key informant interviews (n=24) with active-duty AYA cancer patients, cancer care providers, and commanding officers at both a military medical center and a military post in Hawaii. Subsequently, content analysis and thematic abstraction produced results that were sorted to characterize the material, psychosocial, and behavioral domains of financial hardship. Finally, investigators employed health behavioral change theories to construct a conceptual framework. Results: Data analysis revealed that young active-duty military patients’ experiences of financial hardship following a cancer diagnosis occur within material, psychosocial, and behavioral domains that are uniquely situated within the environments of AYA development and military culture. Hence, we elaborated upon an existing conceptual framework of the financial hardship of cancer, by extending it to capture two meso-level contexts that emerged from our findings: (1) life course development and (2) occupational culture. Conclusions: Differentiating individual experiences of financial hardship within the contexts of life course development and occupational culture, may enable the development of interventions that are informed by the aspect of financial hardship most impacted by cancer care for this special population. Future research should further explicate the meso-level contexts in our study, and investigate the associations among and between factors within these social and environmental contexts.
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Park, Jae H., Sean Devlin, Charles Lynch, et al. "Impact of Treatment Center Characteristics on Early Death Rates in Patients with Newly Diagnosed Acute Promyelocytic Leukemia: Analysis of Data from the SEER Program." Blood 128, no. 22 (2016): 4008. http://dx.doi.org/10.1182/blood.v128.22.4008.4008.

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Abstract Background: Acute promyelocytic leukemia (APL) is a unique subtype of AML with a high cure rate of 80-90% when treated with all-trans retinoic acid (ATRA)-based therapy. However, early death at presentation or during induction therapy due to hemorrhage remains the major cause for treatment failure. Using the Surveillance, Epidemiology, and End Results (SEER) data, we have previously reported an early death rate of 17.3% (Park J et al. Blood 2011;118:1248). We hypothesized that the early death may be associated with the expertise and availability of blood products at treatment centers and undertook a retrospective cohort study. Methods: APL patients diagnosed between 1992 and 2009 were identified using SEER 13 data. Patients with available survival and treatment center information were eligible for the study. Early death was defined as death within one month of diagnosis. The treatment center information was obtained from the American Hospital Association database and included the following characteristics: number of hospital beds (<200, 200-500, >500), presence of intensive care unit (ICU), presence of trauma center (as a surrogate indicator for availability of on-site blood products), and the teaching status (nonteaching, minor, major). Logistic regression was used to compare early death by selected hospital characteristics. Results: The full-set of pre-specified treatment center information were available from five SEER 13 cancer registries (Iowa, Utah, Detroit, Connecticut, Hawaii); from these registries, we identified 507 eligible patients ofwhom [154 patients (30%)] experienced an early death. Data on bed size, teaching status, ICU presence and trauma center were available in 460, 460, 445 and 434 patients, respectively. Most APL patients were treated at centers with ³200 hospital beds (n=345), dedicated ICU (n=442), trauma center (n=287) and at teaching hospitals (n=349) (see Table 1). Of the treatment center characteristics, analysis revealed that the presence of trauma center was statistically significantly associated with decreased odds of early death (odds ratio: 0.59, 95% CI: 0.39-0.91; p=0.02). Conclusions: Early death remains as the major cause of treatment failure in APL. To the best of our knowledge, this is the first and largest study reporting an association of treatment center characteristics with survival in APL, and suggests a prompt referral of APL patients to a large treatment center may further improve the outcome of these patients. Disclosures Park: Novartis: Consultancy; Baxalta: Consultancy; Juno Therapeutics: Research Funding; Amgen: Consultancy. Douer:Pfizer: Consultancy; Shire: Consultancy, Speakers Bureau; Spectrum: Consultancy; Jazz Pharmaceuticals: Honoraria; Gilled Sciences, Inc: Consultancy.
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Siegel, Robert D., Donna M. Bryant, Holley Stallings, et al. "Fertility preservation: Utilizing QOPI metrics in the quality improvement efforts of the NCI Community Cancer Centers Program (NCCCP)." Journal of Clinical Oncology 30, no. 15_suppl (2012): e16532-e16532. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e16532.

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e16532 Background: The NCCCP is a consortium of 30 community based institutions funded by the NCI. Quality of care has been a priority of the NCCCP with participation in the Quality Oncology Practice Initiative (QOPI) serving as a fundamental element in those efforts. QOPI provides both a metric for baseline assessment and a means for measuring improvement across the network. Participation in QOPI became required with expansion of the NCCCP in 2010. Utilizing QOPI methodology, we describe our efforts to optimize adherence to fertility preservation standards of care. NCI Contract No. HHSN261200800001E Methods: A data sharing agreement allows individual practice performance to be electronically forwarded to the NCI twice a year where it is aggregated with the other NCCCP QOPI participants. This allows for ongoing evaluation of group statistics as well as comparisons between participating institutions. Those practices scoring highest on individual parameters are queried for best practices. Results: In Spring 2011, 38 practices/23 NCCCP sites participated resulting in 2653 chart reviews. 258 charts were applicable to fertile individuals as defined by QOPI. 46 charts were in compliance with suggested standards (17.8%) compared with the national rate of 26.1%. Four practices performed well above the national average and became the NCCCP's leaders for establishing best practices. The NCCCP then embarked upon a process of defining barriers to compliance with the fertility preservation recommendations, created an assessment tool by which each practice could identify the degree it integrated fertility preservation into their care models, and began the process of integrating nationally available educational materials and speakers. QOPI metrics will be used to measure the impact of these interventions. Conclusions: QOPI is a useful tool for measuring quality within a network, identifying barriers to compliance with ASCO fertility preservation recommendations and assessing quality improvement efforts. This methodology has allowed us to proceed with quality initiatives despite the logistical challenges of working with institutions and physicians from Maine to Hawaii.
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Jewett, Patricia, Rachel I. Vogel, Rahel G. Ghebre, et al. "Telehealth: Reducing or increasing cancer care disparities?" Journal of Clinical Oncology 39, no. 15_suppl (2021): 1582. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.1582.

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1582 Background: During the COVID-19 pandemic, most cancer care in the United States transitioned to telehealth (phone or video visits) to reduce infection risks for patients and providers. Telehealth may simplify care logistics (e.g. reduce travel and waiting times), but it may also unintentionally exacerbate existing disparities in healthcare utilization by race/ethnicity, age, or rural/urban status. As telehealth will likely continue long-term, we examined telehealth use at a comprehensive cancer center during the COVID-19 pandemic across patient populations with established disparities in cancer treatment and outcomes. Methods: We retrospectively reviewed telehealth visits from March until December 2020 among individuals diagnosed with cancer at the University of Minnesota Masonic Cancer Center (MCC). We used Chi-squared tests and GEE logistic regression to compare video vs. phone visits by age, urban/rural status, and race/ethnicity (American Indian / American Native [AIAN], Asian, Non-Hispanic Black/African American [NH Black/AA], Hispanic, Multiple, Native Hawaiian / Pacific Islander [NHPI], NH White). Results: Over the study period, 42,171 telehealth visits were performed with 11,097 patients at the MCC. Patients had a mean age of 62.7±13.9 years; 59.2% were female; 88.7% lived in urban areas; 90.0% of patients were NH White, 4.4% NH Black/AA, 3.0% Asian, 1.5% Hispanic, 0.8% AIAN, 0.3% of multiple races, and 0.1% NHPI. The most common cancer sites were breast (24.1%), hematological (21.0%), gynecologic (10.0%), and lung (8.4%). NH White individuals were more likely (53.9%) to use video than AIAN (39.7%), Black/AA (37.8%), or NHPI individuals (34.9%). Video use was less common among rural (45.3%) than urban (53.7%; p<.0001) residents, and among individuals aged 65 or older (45.2%) vs. younger than 65 (59.5%; p<.0001). In a logistic regression, adjusted for continuous age and urban/rural status, all race/ethnic groups except Multiple were less likely to use video than NH White individuals (vs. phone; Table). Conclusions: Our findings underscore disparities in telehealth use for cancer care across historically underserved populations. Future research should evaluate potential underlying contributors to these disparities such as technology access, internet capability, and fear of discrimination. Additional research is also needed to determine whether video vs. phone visits affect cancer outcomes, therefore indicating true disparity.[Table: see text]
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Acoba, Jared David, Sharon Tamashiro, and Marci Chock. "Perceived value of cancer survivorship care among Asians and Native Hawaiian/Pacific Islanders." Journal of Clinical Oncology 38, no. 15_suppl (2020): e22522-e22522. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e22522.

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e22522 Background: Numerous studies have evaluated the impact of cancer survivorship care. However, no study to date has focused on Asian or Native Hawaiian/Pacific Islander (NH/PI) cancer survivors. It has been well documented that Asian and NH/PI patients often suffer from inferior cancer outcomes compared to White patients, and differences in their experience with cancer survivorship care could contribute to this disparity. Methods: Surveys were sent to 1410 cancer survivors who were treated at a community cancer center with curative intent and who had received survivorship care plans between Jan 2014 and June 2018. The 26-item questionnaire evaluated patients’ perception of various aspects of their survivorship care plan and follow-up physician visits. All responses were anonymous. Results: Of the 360 patients who responded, 24% were White, 54% Asian, and 13% NH/PI. Compared to Whites, Asian and NH/PI patients were younger (p = 0.004), less educated (p = 0.004), and reported a lower income (p < 0.0005). Among all patients, 62% reported that the survivorship care plan was “very helpful” and 86% rated their satisfaction with physician follow-up visits as “very good” to “excellent.” There were no racial differences in satisfaction with either survivorship care plan or physician follow-up. In a multivariate binary logistic regression, Asians and NH/PI patients were significantly more likely to rate ongoing survivorship care as helpful compared to Whites, OR 4.08 (95%CI, 2.13-7.82). Conclusions: There were no racial differences in patient satisfaction with their survivorship care plans and follow-up care. However, Asian and NH/PI patients valued ongoing cancer survivorship care follow-up significantly more than White patients. Whether more extensive survivorship care would lead to improved outcomes among Asian and NH/PI cancer patients should be investigated further.
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Dissertations / Theses on the topic "Cancer Research Center of Hawaii"

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Silberholz, John. "Analytics for Improved Cancer Screening and Treatment." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/101290.

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Thesis: Ph. D., Massachusetts Institute of Technology, Sloan School of Management, Operations Research Center, 2015.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 139-156).<br>Cancer is a leading cause of death both in the United States and worldwide. In this thesis we use machine learning and optimization to identify effective treatments for advanced cancers and to identify effective screening strategies for detecting early-stage disease. In Part I, we propose a methodology for designing combination drug therapies for advanced cancer, evaluating our approach using advanced gastric cancer. First, we build a database of 414 clinical trials testing chemotherapy regimens for this cancer, extracting information about patient demographics, study characteristics, chemotherapy regimens tested, and outcomes. We use this database to build statistical models to predict trial efficacy and toxicity outcomes. We propose models that use machine learning and optimization to suggest regimens to be tested in Phase II and III clinical trials, evaluating our suggestions with both simulated outcomes and the outcomes of clinical trials testing similar regimens. In Part II, we evaluate how well the methodology from Part I generalizes to advanced breast cancer. We build a database of 1,490 clinical trials testing drug therapies for breast cancer, train statistical models to predict trial efficacy and toxicity outcomes, and suggest combination drug therapies to be tested in Phase II and III studies. In this work we model differences in drug effects based on the receptor status of patients in a clinical trial, and we evaluate whether combining clinical trial databases of different cancers can improve clinical trial toxicity predictions. In Part III, we propose a methodology for decision making when multiple mathematical models have been proposed for a phenomenon of interest, using our approach to identify effective population screening strategies for prostate cancer. We implement three published mathematical models of prostate cancer screening strategy outcomes, using optimization to identify strategies that all models find to be effective.<br>by John Silberholz.<br>Ph. D.
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Relyea, Stephen L. (Stephen Lawrence). "An analytics approach to designing clinical trials for cancer." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/82727.

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Thesis (S.M. in Operations Research)--Massachusetts Institute of Technology, Sloan School of Management, Operations Research Center, 2013.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 67-71).<br>Since chemotherapy began as a treatment for cancer in the 1940s, cancer drug development has become a multi-billion dollar industry. Combination chemotherapy remains the leading treatment for advanced cancers, and cancer drug research and clinical trials are enormous expenses for pharmaceutical companies and the government. We propose an analytics approach for the analysis and design of clinical trials that can discover drug combinations with significant improvements in survival and toxicity. We first build a comprehensive database of clinical trials. We then use this database to develop statistical models from earlier trials that are capable of predicting the survival and toxicity of new combinations of drugs. Then, using these statistical models, we develop optimization models that select novel treatment regimens that could be tested in clinical trials, based on the totality of data available on existing combinations. We present evidence for advanced gastric and gastroesophageal cancers that the proposed analytics approach a) leads to accurate predictions of survival and toxicity outcomes of clinical trials as long as the drugs used have been seen before in different combinations, b) suggests novel treatment regimens that balance survival and toxicity and take into account the uncertainty in our predictions, and c) outperforms the trials run by the average oncologist to give survival improvements of several months. Ultimately, our analytics approach offers promise for improving life expectancy and quality of life for cancer patients at low cost.<br>by Stephen L. Relyea.<br>S.M.in Operations Research
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Cowan, Elizabeth Alice. "An investigation of the therapeutic potential of phenylaminoalkyl selenides through mechanistic and biological studies and an exploration of ciber: the center of innovative biomaterial education and research." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42937.

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The overproduction of reactive oxygen species (ROS) have been linked to diseases and other pathologies. As therapeutic agents, antioxidants have been tested and some shown to attenuate these diseases by relieving oxidative stress. The May laboratory has previously developed a family of phenylaminoalkyl selenides and has demonstrated the antihypertensive and antioxidant properties of these compounds. To further understand the antioxidant property of these selenide compounds, the two step mechanism of the reaction between the selenoxide form and glutathione was investigated by stopped-flow and mass spectrometry, leading to the detection and characterization of a novel thioselenurane intermediate. Mass spectrometry studies supported the redox cycle of the selenide compounds as a straightforward cycle with no byproducts or side reactions and was the first evidence reported of a thioselenurane intermediate present in a reduction reaction of a selenoxide. The therapeutic potential of these compounds was further supported by cell and histological studies demonstrating their ability to alleviate the cardiotoxic effect of anthracyclines without affecting the anti-cancer property of the drugs. Codosage of a phenylaminoethyl selenide with Doxorubicin decreased the infiltration of inflammation cells in the myocardium of mice. Phenylaminoethyl selenides were also able to maintain the body weight of mice treated with Doxorubicin, compared to mice treated with Doxorubicin alone. In order to make the possibility of using Phenylaminoalkyl selenides as therapeutic agents or supplements with other agents, delivery of the compounds was investigated. N acetyl phenylaminoethyl selenides were successfully encapsulated into poly(lactic-co-glycolic) (PLGA) nanoparticles using the nanoprecipitation technique. An attempt was made to demonstrate the ability of these selenide- nanoparticles to reduce cellular oxidative stress caused by incubation with LPS. Future studies are needed to optimize the loading of the selenide compounds into nanocarriers and to demonstrate the ability of the encapsulated drug to work as the free drug. The long term goal of this research is to fully understand the potential of phenylaminoalkyl selenides as an efficient therapeutic agent for ailments derived from increased levels of ROS and a state of oxidative stress. As a supplemental project funded by the National Science Foundation, the Center for Innovative Biomaterial Education and Research (CIBER) was created. Enzymatically catalyzed reaction and polymerizations were investigated using Candida antarctica Lipase B (CALB). Several CALB catalyzed Michael addition reactions were successful and yielded compounds that could be used as future reactants and monomers. As an education requirement of the project a website was created in order to educate the public of the importance, sources and uses of biomaterials. The website provides information for all levels of students and educators. This center has allowed The Georgia Institute of Technology to form relationships and exchange programs with leading universities around the world allowing the exchange of knowledge and research in biomaterials.
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Skogeby, Richard. "Performance assessment of fluorescent nuclear track detectors in physically optimised spread-out Bragg peaks : Carried out at the German Cancer Research Center." Thesis, Umeå universitet, Radiofysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144482.

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Clinical heavy ion beams provide the most accurate means of external radiation treatment of tumors available. The study of energetic heavy ions on individual cells have been hampered by shortcomings in available detector technology. The fluorescence nuclear track detector developed by the Landauer Inc. is a small chiplike detector with all the properties needed for these kinds of studies. It is biocompatible, autoclavable, does not require post-irradiation chemical processingand allows the readout of a sufficient number of physical parameters for the determination of a particle’s radiobiological and physical properties. Previous studies in clinical spread-out Bragg peaks have shown a discrepancy in what is detected to what is seen in Monte Carlo radiation transport simulations. While the fluence of heavy primary ions agrees to within one percent, the detection of fragments is underestimated by at least an order of magnitude. In this thesis the performance of the track-recording has been assessed for light ion fragmentsfrom hydrogen, helium and carbon primary particles in physically optimised spread-out Braggpeaks. The underestimation of light ion fragments for carbon beams, mentioned in previousstudies, was reproduced. The underestimation of light ion fragments is prevalent also for helium primary particles. No significant amount of lost tracks are seen in hydrogen beams. The analysis verifies the hypothesis that the detection of large angle trajectories for light ion fragments is not a principal limitation of the detector. The underestimation most probably stems from some limiting features of the readout and image analysis procedure.
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Bitsko, Matthew John. "Psychosocial Adjustment of Adolescent Cancer Survivors: Time Perspective and Positive Emotions as Mediators to Quality of Life and Benefit Finding." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/673.

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Adolescents with cancer are surviving at improved rates with levels of psychopathology in line with their healthy peers. Thus, recent psycho-oncology research is focusing on finding significant predictors to their positive adjustment and psychosocial functioning. The author examined adolescent cancer survivors (n = 50; diagnosis age = 10 – 21; 2 – 10 years post-diagnosis) to test the mediation effects of positive emotionns (satisfaction with life, subjective happiness, and optimism) and time perspective on the outcome variables quality of life and benefit finding with demographic/medical variables (gender, number of treatments received for cancer, and previous psychotherapy) as independent variables. Results indicated that positive emotions fully mediated the relationship between the number of treatments received for cancer and quality of life and partially mediated the relationship between having engaged in psychotherapy and quality of life with adolescent cancer survivors. Importantly, results indicated that patients' with a relapse diagnosis scored significantly different than those with no relapse diagnosis on quality of life. Although positive emotions were significantly associated with scores on benefit finding in a positive direction, benefit finding did not fit two of the four criteria for mediation. Time perspective indices did not meet full criteria for significant mediation with the relationships between independent and outcome variables. Regarding time perspective indices, significant associations included: prior participating in psychotherapy was associated with higher scores on a Past-Negative time perspective, the more treatments received for cancer was associated with higher scores on a Present-Focused time perspective, and higher scores on the Past-Negative time perspective was associated with lower scores on benefit finding. Discussion centers on the use of evidence-based interventions that cultivate positive emotions with adolescent cancer survivors and the utility of implementing quality of life assessment in pediatric medical settings. Continued emphasis is placed on larger sample sizes via multi-center cooperation that may better illustrate adjustment difficulties within subgroups of this population (i.e. relapse diagnosis). Future research considerations are provided for the constructs of time perspective and benefit finding.
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Marusak, Charles. "MT1-MMP: TARGETING THE CENTER OF MELANOMA METASTASIS, GROWTH AND TREATMENT RESISTANCE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1548327646756039.

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Wen-ChingChen and 陳文菁. "The Action Research to Establish a School Reentry Care Model for School-age Children with Cancer: A Case of Medical Center in Southern Taiwan." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/73745663042270030155.

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CHUNG, YA-PING, and 鍾雅萍. "Research on the Quality of Medical Relationship and Patient Behavioral Intention through the Effectiveness of Shared Decision Making - A Study of Breast Cancer REH in a Medical Center." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/73kyf7.

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碩士<br>國立高雄應用科技大學<br>企業管理系碩士在職專班<br>106<br>The Ministry of Health and Welfare has vigorously promoted the Shared Decision Making of medical and healthcare since 2016. The Sharing Decision Making aid is a medical communication tool actively promoted by medical institutions to promote the patient's safety and self-rights, and building a platform for communication and shared values by the concept of knowledge, communication , and respect. In this study, the tools of Shared Decision Making (SDM) were taken as the research focus to explore the effect of breast cancer medicine Sharing Decision-Making in patients with breast cancer surgery in Kaohsiung Veterans General Hospital. This study analyzes the attitudes and feelings for medical communication and and shared values, effectiveness of the Shared Decision Making to medical relationship quality and patient's intention. Hoping to put forward more detailed research reports and suggestions as a reference for the clinical use of medical personnel and the direction and suggestions of the development of hospital managers strategy. In this study, 67 patients who were diagnosed with breast cancer in Kaohsiung Veterans General Hospital were enrolled in this study. Using SPSS 24.0 statistical software for data analysis and hypothesis testing, the results: 1. The better medical communication and the higher the shared values, the better Shared Decision Making effectiveness. 2. Both better medical communication and share values, the higher medical relationship quality and patient behavioral intent. 3. The more consideration Shared Decision Making, the higher medical relationship quality. 4. The Shared Decision Making effectiveness plays a complete through effect in the medial communication and medical relationship quality. 5. The Shared Decision Making Effectiveness plays a complete through effect in the share values and medical relationship quality. 6. Breast cancer rehabilitation Shared Decision Making effectiveness is well in Kaohsiung Veterans General Hospital .
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Stasko, Carly. "A Pedagogy of Holistic Media Literacy: Reflections on Culture Jamming as Transformative Learning and Healing." Thesis, 2009. http://hdl.handle.net/1807/18109.

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This qualitative study uses narrative inquiry (Connelly & Clandinin, 1988, 1990, 2001) and self-study to investigate ways to further understand and facilitate the integration of holistic philosophies of education with media literacy pedagogies. As founder and director of the Youth Media Literacy Project and a self-titled Imagitator (one who agitates imagination), I have spent over 10 years teaching media literacy in various high schools, universities, and community centres across North America. This study will focus on my own personal practical knowledge (Connelly & Clandinin, 1982) as a culture jammer, educator and cancer survivor to illustrate my original vision of a ‘holistic media literacy pedagogy’. This research reflects on the emergence and impact of holistic media literacy in my personal and professional life and also draws from relevant interdisciplinary literature to challenge and synthesize current insights and theories of media literacy, holistic education and culture jamming.
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Books on the topic "Cancer Research Center of Hawaii"

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United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies. Labor, health, and education issues in the state of Hawaii: Hearing before a subcommittee of the Committee on Appropriations, United States Senate, One Hundred Eighth congress, second session, special hearing, February 18, 2004, Honolulu, HI. U.S. G.P.O., 2004.

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Kiefer, Max. MD Anderson Cancer Center, Houston, Texas. U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 2001.

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Meeting, United States President's Cancer Panel. President's Cancer Panel Meeting: Transcript of proceedings, November 16-17, 2000 : Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee. National Cancer Institute, 2000.

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United States. President's Cancer Panel. Meeting. President's cancer panel meeting: Transcript of proceedings, September 11, 2006 : University of Minnesota Cancer Center, Minneapolis, MN. National Cancer Institute, National Institutes of Health, Department of Health & Human Services, 2007.

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United States. President's Cancer Panel. Meeting. President's Cancer Panel Meeting: Cancer prevention and control research in the 21st century : Arizona Cancer Center, Kiewit Auditorium, Tucson, Arizona, November 17, 1998. National Cancer Institute, 1999.

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Moffitt Cancer Center: 25 years : A bold beginning, a boundless future. H. Lee Moffitt Cancer Center and Research Institute, 2011.

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United States. President's Cancer Panel. Meeting. President's Cancer Panel Meeting: Transcript of proceedings, June 15-16, 2000 : Eppley Cancer Center, University of Nebraska, Omaha, Nebraska. [National Cancer Institute, 2000.

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United States. President's Cancer Panel. Meeting. President's Cancer Panel Meeting: Transcript of proceedings, January 24, 2005, Memorial Sloan-Kettering Cancer Center, New York, New York. National Cancer Institute, 2005.

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United States. President's Cancer Panel. Meeting. President's Cancer Panel Meeting: Transcript of proceedings, September 27, 2004 : the Novice G. Fawcett Conference Center, Columbus, Ohio. National Cancer Institute, 2005.

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United States. President's Cancer Panel. Meeting. President's Cancer Panel Meeting: Transcript of proceedings, November 1, 2004 : the University of Texas M.D. Anderson Cancer Center, Houston, Texas. National Cancer Institute, 2005.

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Book chapters on the topic "Cancer Research Center of Hawaii"

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Donaldson, Sarah S., Michael P. Link, I. Ross McDougall, Bruce R. Parker, and Stephen J. Shochat. "Clinical investigations of children with Hodgkin’s disease at Stanford University Medical Center." In Cancer Treatment and Research. Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-1739-5_25.

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Al-Hussaini, Maysa. "Case Study: Research Ethics Committee at King Hussein Cancer Center, Jordan." In Research Ethics Forum. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-65266-5_31.

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Al-Omari, Amal. "Clinical Research Management at the King Hussein Cancer Center, Amman, Jordan." In Research Ethics Forum. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-65266-5_36.

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Cheng, Lili, Linda Stone, Shelly Farnham, Ann Marie Clark, and Melora Zaner. "HutchWorld: Lessons Learned A Collaborative Project: Fred Hutchsinson Cancer Research Center & Microsoft Research." In Virtual Worlds. Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/3-540-45016-5_2.

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Tajima, Kazuo, Kaoru Hirose, Manami Inoue, Toshiro Takezaki, and Nobuyuki Hamajima. "Exercise and Cancer Prevention: Study from Hospital-Based Epidemiologic Research Program at Aichi Cancer Center (HERPACC)." In Exercise for Preventing Common Diseases. Springer Japan, 1999. http://dx.doi.org/10.1007/978-4-431-68511-1_12.

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Zamenhof, R., H. Madoc-Jones, O. Harling, et al. "The Neutron Capture Therapy Research Program at New England Medical Center and the Massachusetts Institute of Technology." In Progress in Neutron Capture Therapy for Cancer. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3384-9_4.

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Lang, Elke, Thomas Förster, and Claus-Wilhelm von der Lieth. "The Integration of the Cambridge Crystallographic Data Files into the Relational Information Network of the German Cancer Research Center." In Software Development in Chemistry 4. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75430-2_5.

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Hussain, Fazal, Riad El Fakih, and Mahmoud Aljurf. "Data Management." In Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-64492-5_15.

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AbstractEffective data management is critical for quality research in any hematopoietic stem cell transplantation (HSCT) center for accuracy, reliability, and validity of the data. HSCT research is a dynamic and multi-domain process encompassing innovative therapeutic modalities, techniques, and interventions to change the existing standard of care and optimize survival outcomes and patients’ quality of life. Research has evolved as one of the core competencies for the standardization, accreditation, and academic standing of the transplant center. The Data Unit is the center of gravity and the hub of research (databases, registries, translational research, and randomized control trials) in a quality cancer care facility. HSCT data collection, collation, and interpretation have become an integral part of the treatment rather than an option. Quality assurance (QA) and continuous quality improvement (CQI) in data management are pivotal for credibility, measurable/quantifiable outcomes, clinically significant impact, and setting benchmarks. Quality assurance, ethical conduct, and monitoring of HSCT data are the hallmarks of a center of excellence in galvanizing the therapeutic interventions and optimizing the outcomes.
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"International Arctic Research Center Fellowships for Cancer Research." In The Grants Register 2021. Palgrave Macmillan UK, 2020. http://dx.doi.org/10.1057/978-1-349-95988-4_487.

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"International Arctic Research Center Fellowships for Cancer Research." In The Grants Register 2020. Palgrave Macmillan UK, 2019. http://dx.doi.org/10.1057/978-1-349-95943-3_471.

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Conference papers on the topic "Cancer Research Center of Hawaii"

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Paulino, Yvette C., Laura Biggs, Wayne Buente, et al. "Abstract A116: University of Guam/University of Hawaii Cancer Center Partnership leads areca (betel) nut research in the Pacific Islands." In Abstracts: Eleventh AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; November 2-5, 2018; New Orleans, LA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7755.disp18-a116.

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Robinett, Hali R., Helen JD Whippy, and Carl-Wilhelm Vogel. "Abstract B24: Stimulating the development of research and training in cancer health disparities through the University of Guam (UOG)/University of Hawaii Cancer Center (UHCC) partnership." In Abstracts: Fifth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; Oct 27–30, 2012; San Diego, CA. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1055-9965.disp12-b24.

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Robinett, Hali R., Helen J. D. Whippy, John A. Peterson, et al. "Abstract A82: University of Guam/University of Hawaii Cancer Center Partnership: Celebrating 10 years of research, training, education, and outreach to reduce cancer health disparities among Pacific Islanders." In Abstracts: Sixth AACR Conference: The Science of Cancer Health Disparities; December 6–9, 2013; Atlanta, GA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7755.disp13-a82.

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Smith, Alfred. "The University of Texas M.D. Anderson Cancer Center Proton Therapy Facility." In APPLICATION OF ACCELERATORS IN RESEARCH AND INDUSTRY: 17TH International Conference on the Application of Accelerators in Research and Industry. AIP, 2003. http://dx.doi.org/10.1063/1.1619893.

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Becerra-Fernandez, Irma, Greg Madey, Michael Prietula, Domingo Rodriguez, Ricardo Valerdi, and Timothy Wright. "Design and Development of a Virtual Emergency Operations Center for Disaster Management Research, Training, and Discovery." In 2008 41st Annual Hawaii International Conference on System Sciences. IEEE, 2008. http://dx.doi.org/10.1109/hicss.2008.115.

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Bloch, Charles, Floyd D. McDaniel, and Barney L. Doyle. "Proton Therapy At Siteman Cancer Center: The State Of The Art." In APPLICATION OF ACCELERATORS IN RESEARCH AND INDUSTRY: Twenty-First International Conference. AIP, 2011. http://dx.doi.org/10.1063/1.3586128.

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Adams-Campbell, Lucile, Kepher Makambi, Wayne Frederick, and Worta McCaskill -Stevens. "Abstract A58: Breast cancer risk estimates from the CARE and GAIL models among black women: Howard University Cancer Center experience." In Abstracts: Frontiers in Cancer Prevention Research 2008. American Association for Cancer Research, 2008. http://dx.doi.org/10.1158/1940-6207.prev-08-a58.

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Leifert, Jens A., Cornelia Schulz, Andreas Jaehne, Mirjam Elze, James Balmford, and Oliver Opitz. "Abstract B17: A novel cancer prevention management strategy at the Comprehensive Cancer Center Freiburg (CCCF), Germany." In Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Nov 7-10, 2010; Philadelphia, PA. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1940-6207.prev-10-b17.

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Rui Xue, Jianying Li, and D. J. Streveler. "Microarray gene expression profile data mining model for clinical cancer research." In 37th Annual Hawaii International Conference on System Sciences, 2004. Proceedings of the. IEEE, 2004. http://dx.doi.org/10.1109/hicss.2004.1265356.

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Elder, Sarah G., Jerry S. Lee, Michelle A. Berny-Lang, and Sean E. Hanlon. "Abstract 1568: Advancing convergence and innovation in cancer research: National Cancer Institute Center for Strategic Scientific Initiatives (CSSI)." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-1568.

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Reports on the topic "Cancer Research Center of Hawaii"

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Ukoli, Flora A., LaMonica Stewart, M. Sanderson, A. Pasipanodya, Carlton Adams, and Thomas A. Laveist. Meharry-Johns Hopkins Center for Prostate Cancer Research. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada610809.

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Ukoli, Flora A., and Thomas A. LaVeist. Meharry-Johns Hopkins Center for Prostate Cancer Research. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada617381.

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Howard, Daniel. Meharry-Johns Hopkins Center for Prostate Cancer Research. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada575947.

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Shriver, Craig D. Breast Cancer Translational Research Center of Excellence FY12-14. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada585301.

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Shriver, Craig D., and Lee Bronfman. Breast Cancer Translational Research Center of Excellence FY12-14. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada614971.

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Bovbjerg, Dana H., Christine Ambrosone, Heiddis Valdimarsdottir, Margaret McGovern, Jim Godbold, and Lina Jandorf. Genetic Factors in Breast Cancer: Center for Interdisciplinary Biobehavioral Research. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada442992.

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Bovbjerg, Dana. Genetic Factors in Breast Cancer: Center for Interdisciplinary Biobehavioral Research. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada536846.

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Bovbjerg, Dana H. Genetic Factors in Breast Cancer: Center for Interdisciplinary Behavioral Research. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada429513.

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Bovbjerg, Dana H., Christine Ambrosone, Heiddis Valdimarsdottir, Lina Jandorf, and Margaret McGovern. Genetic Factors in Breast Cancer: Center for Interdisciplinary Biobehaviorial Research. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada422523.

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Bovbjerg, Dana H., Christine Ambrosone, Heiddis Valdimarsdottir, Lina Jandorf, Margaret McGovern, and Jim Godbold. Genetic Factors in Breast Cancer: Center for Interdisciplinary Biobehavioral Research. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada462719.

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