Relevant bibliographies by topics / Cancer research ; chalcone

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Cancer research ; chalcone'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Cancer research ; chalcone"

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Tantawy, Mohamed A., Farid M. Sroor, Magda F. Mohamed, et al. "Molecular Docking Study, Cytotoxicity, Cell Cycle Arrest and Apoptotic Induction of Novel Chalcones Incorporating Thiadiazolyl Isoquinoline in Cervical Cancer." Anti-Cancer Agents in Medicinal Chemistry 20, no. 1 (2020): 70–83. http://dx.doi.org/10.2174/1871520619666191024121116.

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Background: Chalcones are naturally occurring compounds found in various plant species which are widely used for the traditional popular treatments. Chalcones are distinguished secondary metabolites that are reported to display diverse biological activities such as antiviral, antiplatelet, anti-inflammatory, anticancer, antibacterial and antioxidant agents. The presence of a,ß-unsaturated carbonyl group in chalcones is assumed to be responsible for their bioactivity. In addition, heterocyclic compounds having nitrogen such as isoquinolines are of considerable interest as they constitute the co
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Fikroh, Retno Aliyatul, Sabirin Matsjeh, and Chairil Anwar. "Synthesis and Anticancer Activity of 2’-hydroxy-2-bromo-4,5-dimetoxychalcone Against Breast Cancer (MCF-7) Cell Line." Molekul 15, no. 1 (2020): 34. http://dx.doi.org/10.20884/1.jm.2020.15.1.558.

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Breast cancer is one of cancer causes of death in woman. Chemotherapy is one cancer treatment give toxic effects on normal cells. Alternative of cancer treatment by using flavonoid derivative have potent anticancer to reduce side effects of cancer. Chalcone is family of flavonoid that have biological activity. Chalcone derivatives have potential compound as anticancer agent. Chalcone with the presence halogen, metoxy group in ring B is know to inhibit cancer cells. The aims of this research were to synthesize chalcone derivate with bromo, methoxy, and hyroxy group in ring chalcone and to deter
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Rathore, Swati, Shweta Mishra, Debarshi K. Mahapatra, Shailendra Patil, and Asmita G. Patil. "Thoughtful Insights into the Therapeutic Armamentarium of Chalcones: 10 Years of Glorious Journey." Current Bioactive Compounds 16, no. 6 (2020): 747–808. http://dx.doi.org/10.2174/1573407215666190411150734.

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Background: Naturally occurring chalcones afford diverse pharmacological activities such as anticancer, anti-malarial, anti-inflammatory, anti-tubercular, anti-hypertensive, anti-arrhythmic, antidiabetic, anti-angiogenic, anti-obesity, antiplatelet, anti-oxidant, hypolipidemic and anti-gout. They are frequently being used by the various researchers to design and develop new synthetic chalcones and many novel hybrid analogs as bioactive drugs. Many of these drugs are hybrid molecules, which are designed through molecular hybridization theory, and have displayed multiple pharmacological and medi
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Harmastuti, Nuraini, Rina Herowati, Dyah Susilowati, Harno Dwi Pranowo, and Sofia Mubarika. "SYNTHESIS AND CYTOTOXIC ACTIVITY OF CHALCONE DERIVATIVES ON HUMAN BREAST CANCER CELL LINES." Indonesian Journal of Chemistry 12, no. 3 (2012): 261–67. http://dx.doi.org/10.22146/ijc.21340.

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Chalcone, an α,β-unsaturated ketone, has been shown have many biological activities such as anticancer and antifungi. This research was conducted to synthesize the chalcone derivatives and to obtain their cytotoxic activity on human cervix cancer cell lines. Synthesis of chalcone and its derivatives, 4II-methylchalcone, 4II-methoxychalcone, and 3II,4II-dichlorochalcone was carried out using starting materials of benzaldehide and acetofenon, p-methylacetophenone, p-methoxyacetophenone, as well as m,p-dichloroacetophenone through Claisen Schmidt condensation catalized by NaOH in ethanol at 15 °C
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Lu, Chao-Fan, Sheng-Hui Wang, Xiao-Jing Pang, et al. "Synthesis and Biological Evaluation of Amino Chalcone Derivatives as Antiproliferative Agents." Molecules 25, no. 23 (2020): 5530. http://dx.doi.org/10.3390/molecules25235530.

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Chalcone is a common scaffold found in many biologically active compounds. The chalcone scaffold was also frequently utilized to design novel anticancer agents with potent biological efficacy. Aiming to continue the research of effective chalcone derivatives to treat cancers with potent anticancer activity, fourteen amino chalcone derivatives were designed and synthesized. The antiproliferative activity of amino chalcone derivatives was studied in vitro and 5-Fu as a control group. Some of the compounds showed moderate to good activity against three human cancer cells (MGC-803, HCT-116 and MCF
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Mathew, Bijo, Della Grace Thomas Parambi, Vishnu Sankar Sivasankarapillai, et al. "Perspective Design of Chalcones for the Management of CNS Disorders: A Mini-Review." CNS & Neurological Disorders - Drug Targets 18, no. 6 (2019): 432–45. http://dx.doi.org/10.2174/1871527318666190610111246.

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: The development of chalcone-based compounds for CNS disorders has been explored by many research groups. Chalcones are being considered as a potent organic scaffold with widespread applications in the field of drug discovery and medicinal chemistry. The planar or semi-planar geometry of chalcones with various functionalities impinged on the terminal aromatic systems renders the molecule its bio-activity including anti-cancer, anti-malarial, anti-microbial, anti-fungal, antileishmanial, anti-viral, anti-diabetic, anti-hypertensive properties, etc. Moreover, cutting-edge research has been exec
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Sansalone, Lorenzo, Eduardo Veliz, Nadia Myrthil, et al. "Novel Curcumin Inspired Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death." Cancers 11, no. 3 (2019): 357. http://dx.doi.org/10.3390/cancers11030357.

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Glioblastoma (GBM) has a dismal prognosis and successful elimination of GBM stem cells (GSCs) is a high-priority as these cells are responsible for tumor regrowth following therapy and ultimately patient relapse. Natural products and their derivatives continue to be a source for the development of effective anticancer drugs and have been shown to effectively target pathways necessary for cancer stem cell self-renewal and proliferation. We generated a series of curcumin inspired bis-chalcones and examined their effect in multiple patient-derived GSC lines. Of the 19 compounds synthesized, four
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Salem, Marwa S., Rasha A. Hussein, and Wael M. El-Sayed. "Substitution at Phenyl Rings of Chalcone and Schiff Base Moieties Accounts for their Antiproliferative Activity." Anti-Cancer Agents in Medicinal Chemistry 19, no. 5 (2019): 620–26. http://dx.doi.org/10.2174/1871520619666190225122338.

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Background: In a continuous combat against cancer, which is one of the leading causes of mortality now, chalcone and Schiff bases moieties have been incorporated and their antiproliferative activities and associated mechanisms against liver (HepG2) and breast (MCF-7) cell lines in addition to normal fibroblasts (WI-38) have been examined. Methods: Derivatives 4 and 5 of Schiff bases only and chalcone derivatives of Schiff bases 1 and 2 were devoid of any antiproliferative activity. All three compounds (3, 6, and 7) with significant antiproliferative activity were selective and caused no growth
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Kaur, Harmeet, Sapna D. Desai, Jasbir Singh, and Balasubramanian Narasimhan. "Morpholine Based Diazenyl Chalcones: Synthesis, Antimicrobial Screening and Cytotoxicity Study." Anti-Cancer Agents in Medicinal Chemistry 18, no. 15 (2019): 2193–205. http://dx.doi.org/10.2174/1871520618666180830152701.

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Background: Microbial infections have been the major cause of morbidity and mortality for the centuries and continue to present the formidable challenge to the human health. Several studies have been performed to explore the antimicrobial potential of various synthesized chalcone derivatives. The morpholine derivatives are also gaining considerable importance due to diverse biological activities. Hybridization of morpholine and chalcone moiety together can be the useful approach for the development of new effective antimicrobial agents. Methods: A new series of morpholine based heterocyclic di
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Predes, Danilo, Luiz F. S. Oliveira, Laís S. S. Ferreira та ін. "The Chalcone Lonchocarpin Inhibits Wnt/β-Catenin Signaling and Suppresses Colorectal Cancer Proliferation". Cancers 11, № 12 (2019): 1968. http://dx.doi.org/10.3390/cancers11121968.

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The deregulation of the Wnt/β-catenin signaling pathway is a central event in colorectal cancer progression, thus a promising target for drug development. Many natural compounds, such as flavonoids, have been described as Wnt/β-catenin inhibitors and consequently modulate important biological processes like inflammation, redox balance, cancer promotion and progress, as well as cancer cell death. In this context, we identified the chalcone lonchocarpin isolated from Lonchocarpus sericeus as a Wnt/β-catenin pathway inhibitor, both in vitro and in vivo. Lonchocarpin impairs β-catenin nuclear loca
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Dissertations / Theses on the topic "Cancer research ; chalcone"

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Ciupa, Alexander. "Chalcone derivatives in cancer research and tissue engineering." Thesis, University of Bath, 2013. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604571.

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The chalcone motif is a privileged structure present in an extensive range of biologically active molecules. The chalcone structure can also serve as a versatile starting material for more complex molecules in medicinal chemistry. Eleutherobin, isolated from the Australian coral Eleutherobia and sarcodictyin, isolated from the Mediterranean coral Sarcodictyon roseum are natural products displaying nanomolar cytotoxicity against a range of cancer cell lines including Taxol®-resistant cell lines. Both natural products act as microtubule stabilising agents and will be valuable additions to the cl
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Book chapters on the topic "Cancer research ; chalcone"

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"Chalcone and Their Derivatives as Anticancer Agents." In Topics in Anti-Cancer Research Volume 6, edited by Zahoor A. Wani and Suaib Luqman. Bentham Science Publishers Ltd., 2017. http://dx.doi.org/10.2174/9781681084558117060007.

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McCluskey, Adam, and Cecilia Russell. "Chalcones: Potential Anticancer Agents." In Translational Research in Cancer. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.91441.

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Chalcones in their various guises have been considered either valid and critically important lead compounds in the development of novel anticancer agents or as pan assay interference compounds, PAINS. Medicinal chemistry is replete with exemplars from both “camps” progressing to clinical utility. Chalcones offer a simple starting point for the development of specific compounds with high levels of activity toward key biological targets. Chalcones have been shown to display a wide array of anticancer compounds. This chapter seeks to offer an overview of key examples in an effort to encourage further reading and research in development in this intriguing space.
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Conference papers on the topic "Cancer research ; chalcone"

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Hussein, Ola, Feras Alali, Ala-Eddin Al Moustafa, and Ashraf Khalil. "Design, Synthesis and Biological Evaluation of Novel Chalcone Analogs as Potential Therapeutic Agents for Castration-Resistant Prostate Cancer." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0179.

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Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of patients ultimately progress to a lethal form of the disease, termed as castration-resistant prostate cancer (CRPC), which currently lacks curative therapeutic options and is associated with poor prognosis. Therefore, the development of novel treatment modalities for PCa is urgently needed. Chalcones, also known as 1,3-diphenyl-2-propen-1-ones, are among the highly attractive
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Journal articles
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