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Dissertations / Theses on the topic 'Cancer tumer'

Author: Grafiati
Published: 6 September 2023
Last updated: 31 July 2025

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1

Lale, Shantanu Vijay. "Development of stimuli responsive polymeric nanosystems for cancer therapeutics." Thesis, IIT Delhi, 2016. http://localhost:8080/xmlui/handle/12345678/6999.

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2

McGinley, Susan. "Sensitizing Tumor Response to Cancer Therapy." College of Agriculture and Life Sciences, University of Arizona (Tucson, AZ), 2008. http://hdl.handle.net/10150/622086.

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3

Hoarau, Jessica. "Halfway Between 2D Models and Animal Models : a New Multicellular 3D Spheroid Model Organized to Study Tumor-Endothelium Interactions in Ovarian Cancer." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS111.

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Le cancer de l'ovaire (CO) est la cinquième cause de décès chez les femmes qui se caractérise par son diagnostic tardif (stades FIGO III et IV) et par l’importance de ses métastases abdominales souvent observées au moment du diagnostic. Le traitement repose sur une chirurgie cytoréductive complète associée à une chimiothérapie. Malheureusement, parmi les patientes ayant une rémission clinique complète après la fin du traitement initial, 60% des personnes atteintes d'un cancer épithélial de l'ovaire (CEO) à un stade avancé rechuteront dans les cinq ans.L'importance de la néo-angiogenèse dans le
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4

Stemmer, Kerstin. "Molecular Characteristics of Kidney Cancer." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-73925.

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5

Bonneau, Claire. "Étude des mécanismes de récidive métastatique dans les cancers du sein luminaux de stade précoce : impact du microenvironnement tumoral Caractérisation moléculaire des cancers du sein en pratique clinique A subset of activated cancer associated fibroblasts is associated with distant relapse in early luminal breast cancers." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2365&f=17162.

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Les cancers du sein de stade précoce constituent un enjeu de santé publique du fait de leur fréquence élevée (70% des nouveaux cas diagnostiqués). Parmi eux, les cancers luminaux (exprimant les récepteurs hormonaux sans surexpression de l’HER2) de stade T1N0, de moins de 2cm sans envahissement ganglionnaire, ont un pronostic spontanément favorable et font ainsi l’objet de peu d’études dédiées. Néanmoins certaines de ces patientes (5 à 10% à 10 ans) vont récidiver avec des métastases à distance et mourir. L’identification de facteurs pronostiques pour ces tumeurs et une meilleure compréhension
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Dacheux, Estelle. "Implication de la protéine onco-suppressive BRCA1 dans la régulation de la traduction." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10077.

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BRCA1 est l’un des deux gènes majeur de prédisposition au cancer du sein. Les multiples partenaires protéiques de BRCA1 lui confèrent de nombreuses fonctions par lesquelles elle peut assurer la surveillance de l’intégrité cellulaire. L’équipe dans laquelle j’ai mené ma thèse a identifié un nouveau partenaire protéique de BRCA1, la protéine de liaison au poly(A) des ARN messagers PABP1, et a ainsi mis en lumière l’implication de BRCA1 dans la régulation de la traduction [1]. Durant ma thèse, j’ai étudié cette nouvelle fonction de BRCA1 et essayé de comprendre si, et comment, elle pourrait contr
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7

Pålsson, Birger. "Tumour marker CA-50 in pancreatic cancer." Lund : Dept. of Surgery, Lund University, 1993. http://catalog.hathitrust.org/api/volumes/oclc/38154714.html.

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8

Muller, Laure. "Modélisation et traitement du signal de rétrodiffusion lumineuse dans les tissus vivants appliques à la détection de bas niveaux de saturation en oxygène : contribution à l'optimisation de la dosimétrie en thérapie photodynamique anticancéreuse." Vandoeuvre-les-Nancy, INPL, 1994. http://www.theses.fr/1994INPL120N.

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La thérapie photodynamique, basée sur l'affinité pour les tissus tumoraux d'un agent photosensibilisant est un traitement anticancéreux prometteur mais encore en phase de recherche. Parmi les paramètres inconnus, l'action de l'oxygène est un élément essentiel a la définition d'une dosimétrie efficace de la lumière. En effet, sa détermination permet une optimisation de l'action phototoxique ainsi que la détermination d'un seuil de réussite thérapeutique. A ces fins, le développement d'un système adapte aux mesures par voie endoscopique, seul accès au site tumoral, permettant l'évaluation de l'é
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9

Payne, Kyle K. "Immunotherapy of Cancer: Reprogramming Tumor/Immune Cellular Crosstalk to Improve Anti-Tumor Efficacy." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3939.

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Immunotherapy of cancer has been shown to be promising in prolonging patient survival. However, complete elimination of cancer and life-long relapse-free survival remain to be major challenge for anti-cancer therapeutics. We have previously reported that ex vivo reprogramming of tumor-sensitized immune cells by bryostatin 1/ionomycin (B/I) and the gamma-chain (γ-c) cytokines IL-2, IL-7, and IL-15 resulted in the generation of memory T cells as well as CD25+ NKT cells and CD25+ NK cells. Adoptive cellular therapy (ACT) utilizing these reprogrammed immune cells protected FVBN202 mice from tumor
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10

Fumagalli, Debora. "Evaluation of tumor heterogeneity in breast cancer." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/229735.

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Le cancer du sein est le cancer le plus fréquent chez la femme et représente la principale cause de mortalité liée au cancer. Le décés est habituellement causé par le développement de résistance aux traitements et la propagation métastatique de la maladie. Malgré la pertinence clinique, la complexité moléculaire de la maladie et sa dynamique restent à ce jour peu connues.Depuis longtemps, l’hétérogénéité du cancer du sein a été observée au niveau histologique et du profil évolutif clinique, et ces différences ont servi de base pour la classification de la maladie. Avec le développement des tec
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11

Ahmed, Atique U. "Targeting cancer through tumor-selective mRNA stabilization." Thesis, Open University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441144.

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12

Gallerani, Giulia <1986&gt. "Circulating Tumor Cells Investigation in Esophageal Cancer." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7343/1/gallerani_giulia_tesi.pdf.

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Background: An increasing number of studies have established that circulating tumor cells (CTCs) are a heterogeneous population in which cells have different degrees of metastatic potential mainly due to epithelial-mesenchymal transition (EMT). This study aimed to assess the feasibility of circulating esophageal cancer cells identification, characterization and to evaluate their prognostic value in esophageal cancer Methods: In order to closely mimic CTC heterogeneity, MC10A and HMEL cell lines differently forced in EMT are used. Single cell analysis was conducted by DEPArray. We assigned a
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Gallerani, Giulia <1986&gt. "Circulating Tumor Cells Investigation in Esophageal Cancer." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7343/.

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Background: An increasing number of studies have established that circulating tumor cells (CTCs) are a heterogeneous population in which cells have different degrees of metastatic potential mainly due to epithelial-mesenchymal transition (EMT). This study aimed to assess the feasibility of circulating esophageal cancer cells identification, characterization and to evaluate their prognostic value in esophageal cancer Methods: In order to closely mimic CTC heterogeneity, MC10A and HMEL cell lines differently forced in EMT are used. Single cell analysis was conducted by DEPArray. We assigned a
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14

Grillet, Fanny. "Identification et caractérisation des cellules tumorales circulantes dans le cancer colorectal." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONT3510.

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La présence de métastases est un facteur de mauvais pronostic dans les cancers solides et une meilleure compréhension de la dissémination tumorale est nécessaire afin d'améliorer la prise en charge de ces formes avancées. Les cellules tumorales circulantes (CTC) représentent un intérêt majeur dans la pathologie tumorale, d'une part sur le plan clinique en tant que marqueur prédictif et pronostique et d'autre part sur le plan de la compréhension des mécanismes impliqués dans la formation des métastases. Les CTC sont rares et hétérogènes et restent mal caractérisées, et ce, particulièrement dans
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15

Silva, Alexandra Isabel Marques da. "Potencial utilização do ácido acetilsalicílico como anticancerígeno." Master's thesis, [s.n.], 2014. http://hdl.handle.net/10284/4867.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>A aspirina, cuja substância ativa é o ácido acetilsalicílico, representa um dos medicamentos mais utilizados em todo o mundo. Desde a Idade Média até aos dias de hoje, têm vindo a ser descritas inúmeras propriedades terapêuticas nomeadamente: analgésica, antipirética, anti-inflamatória, anti-plaquetária, entre outras. No presente, para além do seu uso no alívio da dor ligeira a moderada, febre e inflamação, a aspirina assume
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Anduran, Emilie. "Bioreductive Activated Prodrugs to Target Tumor Hypoxia." Electronic Thesis or Diss., Montpellier, Ecole nationale supérieure de chimie, 2022. https://theses.enscm.fr/ENSCM_2022_ANDURAN.pdf.

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L'hypoxie est une caractéristique bien connue du microenvironnement dans les tumeurs solides, associée à l'agressivité, aux métastases et à un impact négatif sur le pronostic thérapeutique. Les tumeurs hypoxiques sont généralement résistantes à la radiothérapie et à la chimiothérapie. Considérant son rôle central dans la progression tumorale et la résistance au traitement, l'hypoxie tumorale est considérée comme une cible validée à exploiter en oncologie pour développer des outils diagnostiques et thérapeutiques. Les différences significatives entre le microenvironnement hypoxique et les tissu
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Calixto, João Paulo Duarte. "Concentration of tumor biomarkers using aqueous biphasic systems." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15353.

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Mestrado em Bioquímica - Bioquímica Clínica<br>According to the World Health Organization, around 8.2 million people die each year with cancer. Most patients do not perform routine diagnoses and the symptoms, in most situations, occur when the patient is already at an advanced stage of the disease, consequently resulting in a high cancer mortality. Currently, prostate cancer is the second leading cause of death among males worldwide. In Portugal, this is the most diagnosed type of cancer and the third that causes more deaths. Taking into account that there is no cure for advanced stages of pro
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18

Pearce, Janina V. "The Role of Tumor and Tumor Microenvironment on Breast Cancer-Associated Adipocyte Plasticity." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5933.

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Cancer-associated cachexia is a condition defined by a sustained net-negative energy imbalance. Although the different types of adipose tissue – white, beige, and brown – have been implicated in contributing to cancer-associated cachexia, the mechanisms of these maladaptive changes and their impact on whole-body energy expenditure have not been fully elucidated. Using breast cancer as our model, we demonstrate white adipose tissue browning in murine and human breast cancer; furthermore, we demonstrate that this effect is extremely localized and takes place early in tumor progression. We utiliz
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19

Carvalho, Mafalda Barroso. "Mecanismos virais no Cancro da Próstata: influência do vírus XMRV no aparecimento da doença." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/4076.

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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>Introdução – O cancro da próstata tem tido uma enorme prevalência a nível mundial, justificando um elevado número de estudos não só na procura de novos tratamentos mais eficazes como também dos agentes que causam esta patologia, visto ser essencial saber a sua origem para a introdução de estratégias de prevenção. As causas que levam ao seu aparecimento são ainda desconhecidas, embora se saiba já a influência de alguns fatores, ta
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20

Mendoza, Erin. "Role of p53 in Adaptation to the Tumor Microenvironment." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/204113.

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Tumors cells grow in nutrient and oxygen-deprived microenvironments and adapt to the suboptimal growth conditions by altering their metabolic pathways. The adaptation process commonly creates a tumor phenotype of high glycolytic potential and aggressive growth characteristics which facilitate metastasis and confer resistance to radiation and chemotherapy. Understanding the mechanisms that allow tumors to adapt and survive in their microenvironment is crucial to cancer prevention and control. It was hypothesized that the tumor microenvironment would induce signaling and enzymatic changes, whi
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Mook, Olaf Roger Franciscus. "Tumor development of colon cancer in rat liver." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/88454.

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22

Ho, Victor Wing Heng. "Manipulating the tumor microenvironment to slow cancer growth." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42239.

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The tumor microenvironment encompasses all of the factors and accessory cells which interact with a tumor and, more often than not, are co-opted by tumor-secreted factors to help the cancer grow. In this thesis, we examined elements of the tumor microenvironment, specifically the cancer-promoting M2 macrophages (MΦs) and tumor glucose supply and metabolism. In the vast majority of advanced cancer patients and tumor-bearing animals, their tumors contain MΦs that are profoundly skewed to a cancer-promoting M2 phenotype, which often correlates with a poor prognosis. As well, these same tumor tiss
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23

Shun, Kitty. "Study of two putative prostate cancer tumor markers." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111937.

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The following thesis is based on my study of two candidate prostate cancer tumor markers, namely telomerase and CD9. Accordingly, the thesis will be divided in two main chapters describing the results obtained for each protein. Although these proteins are de-regulated in prostate cancer cells, little is known about their regulation and function in prostate cells. For example, telomerase is generally inactive in normal cells and reactivated in cancer cells and CD9 is a transmembrane protein that is lost as prostate cancer progresses. In chapter 2, I will show that introduction of normal human c
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Eduardo, Rodrigo. "Exploring Tumor Macrophage Interaction in Anaplastic Thyroid Cancer." Master's thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica António Xavier, 2019. http://hdl.handle.net/10362/130111.

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"Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer, with very high mortality rate. Tumor-associated macrophages (TAMs) can represent up to 70% of ATC’s tumor mass, making them an interesting target for novel therapies. In this thesis, the aim was to further understand the crosstalk between ATC and TAMs. To achieve that, cell surface proteomics of two ATC cell lines (C3948 and T235), in mono- or co-culture with THP-1-derived macrophage-like cells, was performed. The protein Spry-4, an inhibitor of the MAPK-ERK pathway, was found to be downregulated in C3948 cells up
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Shahi, Thakuri Pradip. "MODELING ANTI-CANCER DRUG RESISTANCE USING TUMOR SPHEROIDS." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1574725861735168.

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Donald, Carlton Dewitt. "Metastatic characteristics of tumor progression in Prostate Cancer." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1995. http://digitalcommons.auctr.edu/dissertations/3299.

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Tumor biologist have long appreciated that both cell to cell and cell to extracellular matrix (ECM) interactions are involved in the invasive and metastatic events that are characteristic of malignancy. Cancer cell attachment to and invasion of an ECM has been associated with metastatic potential of cell lines of the Dunning rat prostate model. It was postulated that differences observed in the metastatic potential of four Dunning cell lines may correlate with cell-matrix interactions. Four cell lines, highly metastatic ML, MLL, AT-3 and non-metastatic AT-1 were studied. The adhesive, invasive
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To, Nhu Hanh. "Effet des radiations ionisantes sur le système immunitaire de l'hôte et de la tumeur dans un modèle murin d'allogreffe et des cancers du sein localement avancés." Electronic Thesis or Diss., Paris 12, 2022. http://www.theses.fr/2022PA120071.

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La radiothérapie (RT) fait partie des principales armes thérapeutiques dans le traitement des cancers. Actuellement en France, on estime à environ 200.000 le nombre de patients qui reçoivent une RT a divers stades de leur maladie chaque année.L'impact de la RT sur le système immunitaire est reconnu pour son effet "myéloablatif" depuis plusieurs décennies chez les malades candidats aux greffes mais aussi chez les victimes des accidents nucléaires et des explosions aux bombes atomiques ayant induit une insuffisance médullaire mortelle. Au plan thérapeutique, des effets immunostimulateurs de la R
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Zajac, Olivier. "Cancer associated fibroblasts stimulate cancer resistance to therapy." Electronic Thesis or Diss., Université Paris sciences et lettres, 2024. http://www.theses.fr/2024UPSLS001.

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Les patients atteints d'un cancer du rectum localement avancé reçoivent généralement une chimioradiothérapie à base de 5-FU et de radiation. Cependant, seulement 10 à 30 % d'entre eux obtiennent une réponse complète au traitement avec une excellente survie à long terme. En plus de la résistance inhérente des cellules cancéreuses au traitement, le microenvironnement de la tumeur semble jouer un rôle crucial dans a réponse tumorale. Les fibroblastes associés au cancer (CAFs), les cellules non cancéreuses prédominantes dans le cadre de la tumeur, sont organisés autour des cellules cancéruses et,
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Petty, Aaron. "Novel MIG-7 expression increases tumor cell invasion and tumor progression." Online access for everyone, 2008. http://www.dissertations.wsu.edu/Thesis/Spring2008/a_petty_040908.pdf.

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Mehrara, Esmaeil. "Quantitative analysis of tumor growth and response to therapy /." Göteborg : Department of Radiation Physics, University of Gothenburg, 2010. http://hdl.handle.net/2077/21548.

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Prokop, Katherine Jane. "Cell Death Characterization In Tumor Constructs Using Irreversible Electroporation." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/51655.

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Pancreatic and prostate cancer are both prevalent cancers in the United States with pancreatic being one of the most aggressive of all cancers and prostate cancer being one of the most common, ranking as the number one cancer in men. Treatment of both cancers can be quite challenging as the anatomy of the pancreas and prostate, as well as the development and diagnosis of the disease can greatly limit treatment options. Therefore, it is necessary to develop new cancer treatments to help manage and prevent these cancers. Irreversible electroporation is a new non-thermal focal ablation the
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Silveira, Willian Abraham da. "Genetic profile analysis of tumor stem cells in locally advanced breast cancer." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17145/tde-05012016-144854/.

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INTRODUCTION: Breast cancer is the most common cancer in women worldwide and metastatic dissemination is the principal factor related to death by this disease. Breast cancer stem cells (bCSC), defined in this work as the ALDH1high/LIN-/ESA+ population, are thought to be responsible for metastasis and chemoresistance. The objective of this work is to find gene master regulators, in particular transcription factors (TFs), which are controlling the bCSC phenotype. METHODS: We used in this work two groups of datasets with transcriptome data, the discovery dataset group contains one dataset obtaine
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Teinturier, Romain. "Étude des fonctions biologiques et oncosuppressives du gène MEN1 dans le cancer de la prostate et du sein, et son implication dans la régulation de l'expression des récepteurs nucléaires." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1082/document.

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Les mutations du gène suppresseur de tumeur MEN1 sont connues depuis de nombreuses années, pour être à l'origine du syndrome des Néoplasies endocriniennes multiples de type 1 (Syndrome des NEM1). Ce syndrome constitue une maladie héréditaire associée à une perte d'hétérozygotie progressive du gène MEN1, affectant principalement les organes endocrines. Plus récemment, l'implication du gène MEN1 a émergé dans la tumorigénèse d'autres organes, et plus particulièrement dans dans le cancer du sein et le cancer de la prostate, où son rôle reste encore très controversé. Pour mieux déterminer le rôle
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mattei, gianluca. "Tumor Microenvironment: Bioinformatics and Systems Biology Approaches." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1070301.

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Cancers develop in complex microenvironments whose importance was emerging during last years. In fact, cancer microenvironment influences tumor progression and leads to the raising of chemotherapics resistance. Thus, a shift of the focus from cancer cells to cancer cells in their environment is crucial for studying the molecular and metabolic features of tumors in physiological contexts. Within the microenvironment, cancer associated fibroblasts (CAF) are attracting the attention of scientific community since, up to date, it is clear that they are the main component involved in the organizatio
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Svanberg, Frida, and Timothy Shen. "EN FÖRÄNDRAD IDENTITET : Sexualitetens påverkan i samband med bröstcancer. En litteraturöversikt." Thesis, Högskolan i Skövde, Institutionen för hälsa och lärande, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-10471.

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Bakgrund: I Sverige drabbas 8000 kvinnor av bröstcancer varje år. Dessa kvinnor utsätts för både kroppsliga och emotionella biverkningar och förändringar. Syfte: Syftet med denna litteraturöversikt är att belysa hur kvinnor som drabbas av bröstcancer upplever att deras sexualitet påverkas av sjukdom och behandling. Metod: Metoden var en litteraturstudie. Resultat: Ett huvudtema framkom en förändrad identitet; och fem subteman: kroppsliga förändringar, känna sig okvinnlig, relationens betydelse, kommunikationens betydelse för att komma vidare och sjukvårdens betydelse. Slutsats: Resultatet visa
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Lexander, Helena. "Protein expression in prostate cancer /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-617-4/.

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Tachijian, Nataly. "The effect of deactivation or silencing of tumor stroma with angiogenesis inhibitor on malignancy of tumor metastases." Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445622.

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Background: Neuroblastoma (NB) is a pediatric tumor in infants and young children. The survival rate is only around 50 percent for high-risk NB despite advanced and intense multi-modal therapy. Current research aims to find new effective treatment additional to modern therapy to improve prognosis of high-risk NB in children. As such, SU11248 may be a valuable approach for improving treatment and survival as growth factors have crucial roles in tumor growth, angiogenesis, and metastasis. Aim: The aim of this investigation was to examine tissues from SU11248 treated and nontreated tumor-bearing
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Singh, Sunil. "Engineered Organotypic Breast Tumor Model for Mechanistic Studies of Tumor-Stromal Interactions and Drug Discovery." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1616940345310981.

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Jansson, Agneta. "Molecular alterations in colorectal cancer /." Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2002/med743s.pdf.

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Chau, Wing-ka, and 周穎嘉. "Characterization of ovarian tumor-initiating cells and mechanisms of chemoresistance." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197834.

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Chemoresistance remains a major clinical obstacle to effective management of ovarian cancer. Cancer stem cells (or tumor-initiating cells, TICs) have been discovered recently, and have played a pivotal role in changing the view of cancer development; however, the molecular mechanisms by which these cells escape conventional therapies remain elusive. In this study, TICs were isolated from ovarian cancer cells as tumor spheres with specific stem properties under TIC-selective conditions. Unlike non-TICs, TICs strongly express stem cell factor (SCF) and c-Kit. Blocking SCF-c-Kit by SCF neutralizi
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Kassouf, Toufic. "Rôle de la tyrosine kinase Syk, un candidat suppresseur de tumeur, dans l'adhérence intercellulaire et l’intégrité épithéliale de la glande mammaire." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONT3518.

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La spleen tyrosine kinase (Syk) est une protéine kinase cytoplasmique qui intervient dans la signalisation immunitaire. Notre équipe a montré pour la première fois que Syk est exprimée aussi dans les cellules épithéliales mammaires et que son expression est perdue au cours de l’acquisition d’un phénotype invasif/métastatique. Syk agit comme un suppresseur de tumeurs et de métastases dans des modèles de xénogreffes de cancer du sein. Ces observations ont été étayées par des études cliniques qui montrent que la perte d’expression de Syk correspond à un risque accru de développement de métastases
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42

Castellana, Donatello. "Tumor-derived microvesicles in cancer progression : In vitro study in a prostate cancer model." Université Louis Pasteur (Strasbourg) (1971-2008), 2008. http://www.theses.fr/2008STR13034.

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La membrane joue un rôle clé dans un large nombre de processus physiologiques. Lors d’une activation cellulaire, l’externalisation de PS sur la membrane plasmique est suivie par l’émission de microvésicules membranaires (MV). Les MV reflétant le profil antigénique de la cellule et de la stimulation dont elles sont originaires. Le microenvironnement tumoral est enrichi en MV libérées par les cellules qui constitue le tissu cancéreux. En nous focalisant sur l’implication des fibroblastes nous proposons un modèle in vitro dans lequel les cellules normales et cancéreuses communiquent entre elles v
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43

Lara, Ana. "FDG tumor volumetric parameters and outcome in lung cancer and head and neck cancer." Thesis, Boston University, 2012. https://hdl.handle.net/2144/12464.

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Thesis (M.A.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Lung cancer (LC) is the leading cause of cancer mortality worldwide and second most common type of cancer in the United States in both genders. Moreover, Head and neck cancer (HNC) is the sixth most common cance
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44

Atieh, Youmna Marie Lyne. "Interplay between cancer cells and cancer-associated fibroblasts in tumor invasion and metastasis formation." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066140/document.

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Les carcinomes sont des cancers touchant plusieurs organes du corps humain, notamment les seins, le pancréas, les poumons, l'intestin… et sont issus de la transformation de cellules épithéliales en cellules tumorales. Au cours du développement d'une tumeur, les cellules cancéreuses, contrairement aux cellules normales, acquièrent la capacité de se déplacer dans le corps humain, jusqu'à coloniser des organes voisins. Ces colonies sont appelées métastases. Le processus métastatique est responsable de 90% des décès dans le cadre des carcinomes. Ce processus n'est pas dû à l'action isolée des cell
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45

Atieh, Youmna Marie Lyne. "Interplay between cancer cells and cancer-associated fibroblasts in tumor invasion and metastasis formation." Electronic Thesis or Diss., Paris 6, 2017. http://www.theses.fr/2017PA066140.

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Les carcinomes sont des cancers touchant plusieurs organes du corps humain, notamment les seins, le pancréas, les poumons, l'intestin… et sont issus de la transformation de cellules épithéliales en cellules tumorales. Au cours du développement d'une tumeur, les cellules cancéreuses, contrairement aux cellules normales, acquièrent la capacité de se déplacer dans le corps humain, jusqu'à coloniser des organes voisins. Ces colonies sont appelées métastases. Le processus métastatique est responsable de 90% des décès dans le cadre des carcinomes. Ce processus n'est pas dû à l'action isolée des cell
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46

Pedrosa, Ana Rita Ponce Álvares de Águeda. "The role of Jagged1 in adult angiogenesis and in solid tumor development." Doctoral thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2016. http://hdl.handle.net/10400.5/10698.

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Tese especialmente elaborada para obtenção do grau de Doutor em Ciências Veterinárias, especialidade de Ciências Biológicas e Biomédicas<br>Jagged1 (Jag1) is a Notch signaling ligand, which has been described as essential for developmental angiogenesis and to play an important role in several aspects of tumor biology. However the underlying mechanism related to Jagged1/Notch signaling still remain incompletely understood. Therefore this thesis analyzed Jagged1 driven Notch signaling enrolment in adult angiogenesis settings, and in tumor development. To address the role of endothelial Jag1 in
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47

Berthel, Elise. "Recherche des ARNm dont la traduction est régulée par la protéine BRCA1 : vers l’identification de nouveaux outils théranostiques des tumeurs du sein déficientes en BRCA1." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1045/document.

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BRCA1 est l'un des deux gènes majeur de prédisposition au cancer du sein. Les multiples partenaires protéiques de BRCA1 lui confèrent de nombreuses fonctions par lesquelles elle peut assurer la surveillance de l'intégrité cellulaire. L'équipe dans laquelle j'ai mené ma thèse a identifié un nouveau partenaire protéique de BRCA1, la protéine de liaison au poly(A) des ARN messagers PABP1, et a ainsi mis en lumière l'implication de BRCA1 dans la régulation de la traduction. De plus, de récents travaux suggèrent que dans des conditions dangereuses pour la cellule et potentiellement oncogéniques, co
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48

PAZIENZA, VALERIO. "Impact of engineered food on tumor growth and chemoresistance in the frame of pancreatic cancer." Doctoral thesis, Università di Foggia, 2017. http://hdl.handle.net/11369/361941.

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L’impatto della dieta (in particolare quella associate a cicli di restrizione calorica) sui benefici della salute sono stati già dimostrati. Questi includono il miglioramento delle malattie cardiovascolari, insulino resistenza, diabete, disordini immuni, rallentamento dei processi di invecchiamento ed in particolare il ridotto rischio per il cancro. Recenti studi in modelli animali ed in modelli in vitro hanno scoperto un nesso tra i cicli di restrizione calorica ed il ridotto rischio di cancro ed un migliorata efficacia della chemioterapia che è stata già descritta per alcuni tipi di cancro.
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49

Karp, Cristina M. "HRPAP20 a novel tumor progression regulator in breast cancer /." Cincinnati, Ohio : University of Cincinnati, 2005. http://www.ohiolink.edu/etd/view.cgi?acc%5Fnum=ucin1108156644.

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Huijbers, Elisabeth J. M. "Development of a Cancer Vaccine Targeting Tumor Blood Vessels." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170887.

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A treatment strategy for cancer is the suppression of tumor growth by directing an immune response to the tumor vessels, which will destroy the tissue. In this thesis we describe the development of a vaccine that targets antigens expressed around angiogenic vasculature in most solid tumors. These antigens are alternative spliced extra domains of glycoproteins present in the extracellular matrix; e.g. the extra domain-B (ED-B) and extra domain-A (ED-A) of fibronectin and the C-domain of tenascin-C (TNCC). We show that it is possible to break self-tolerance and induce a strong antibody response
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