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Journal articles on the topic 'Cancerous bones tumor'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Nezha, El-bouhi, Sobhi Halima, Chettati Meriem, Fadili Wafaa, and Laouad Inas. "Brown tumor of multiple facial bones associated with tertiary hyperparathyroidism in a patient on maintenance hemodialysis." GSC Advanced Research and Reviews 16, no. 3 (2023): 062–66. https://doi.org/10.5281/zenodo.10613730.

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A brown tumor is a non-cancerous bone lesion that develops due to excessive parathyroid hormone (PTH) levels and can result in bone resorption, ultimately contributing to skeletal deformities. We describe one rare case of a patient on Hemodialysis who develops a brown tumor of multiple facial bones due to Tertiary Hyperparathyroidism.

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Nezha El-bouhi, Halima Sobhi, Meriem Chettati, Wafaa Fadili, and Inas Laouad. "Brown tumor of multiple facial bones associated with tertiary hyperparathyroidism in a patient on maintenance hemodialysis." GSC Advanced Research and Reviews 16, no. 3 (2023): 062–66. http://dx.doi.org/10.30574/gscarr.2023.16.3.0359.

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A brown tumor is a non-cancerous bone lesion that develops due to excessive parathyroid hormone (PTH) levels and can result in bone resorption, ultimately contributing to skeletal deformities. We describe one rare case of a patient on Hemodialysis who develops a brown tumor of multiple facial bones due to Tertiary Hyperparathyroidism.

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Dr., Bushra Iftikhar Dr Faryad Hussain Dr. Muhammad Uzair. "A CASE REPORT ON "TIO" (TUMOUR INDUCED OSTEOMALACIA) PRESENTING MUSCULAR WEAKNESS AND NON-SPECIFIC WEAKNESS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 1778–81. https://doi.org/10.5281/zenodo.2547761.

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<em>Tumor-induced</em><em> osteomalacia is a group of rare disorder that is triggered by an abnormal immune system to a cancerous tumour known as a neoplasm. It is symbolized by a twinge in bones, fissure of bones and weak physique. The main cause of this disorder is the greater serum altitude of fibroblast escalation factor 23. These are hormone amendable phosphate, and vitamin D. Various cancerous cells release FGF-23. Mostly it is released by a little tumour cell whose location is difficult to identify. The name of that tumour is benign mesenchymal tumours. The nature of this cancer is foun

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Tiwari, Vivek, Samrat Sahoo, Mainak Roy, Samir Dwidmuthe, Prashant Bhavani, and Harshavardhan Reddy. "Aneurysmal Bone Cyst of the Third Metatarsal Treated Using Free Nonvascular Fibular Strut Graft–A Rare Case Report." Journal of Orthopaedic Case Reports 14, no. 3 (2024): 136–40. http://dx.doi.org/10.13107/jocr.2024.v14.i03.4318.

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Introduction: An aneurysmal bone cyst (ABC) is an unusual, non-cancerous bone lesion that is characterized by its lytic (causing bone loss), hemorrhagic, and expanding nature. ABCs are relatively rare, making up only 1% of all bone tumors. These cysts are typically found in long bones and the spine but are very rarely seen in the metatarsal bones, making such occurrences quite uncommon. Case Report: In this case report, we present a case of ABC of the 3rd metatarsal in a 26-year-old female with complaints of long-standing foot pain and gradually increasing swelling of the dorsum of the foot. A

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Smitha, T. V., Raunak Kumar Singh, and Naresh Santosh Shet. "Applications of Finite Element Method in Computer Tomography for Cancer and Tumors: A Review." Computer Science & Engineering: An International Journal 12, no. 1 (2022): 135–45. http://dx.doi.org/10.5121/cseij.2022.12114.

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Computer Tomography (CT) is one of the widely used methods in the field of medical imaging. We can obtain images of any parts of the body including Bones, Muscles, Fat, and Organs from CT. The CT scans of internal organs, bone, soft tissue, and blood vessels provide greater clarity and reveal more details than compared to regular X-rays. One of the best numerical methods to study the behavior of cancerous cells or tumors from CT scan images is the Finite Element (FE) method. The FE mesh consists of three steps. Those are mainly Pre mesh, Mesh, Post mesh. It is efficient to create a 3D Model of

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Warpe, Bhushan, Shweta Joshi, Karmi Patel, and Rushi Solanki. "An Unusual Case of Osteofibrous Dysplasia of Tibia in a Female Child." GAIMS Journal of Medical Sciences 4, no. 2 (2024): 157–62. https://doi.org/10.5281/zenodo.13353655.

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<strong>ABSTRACT</strong> Osteofibrous dysplasia (OFD) is an uncommon bone tumor characterized by a non-cancerous, developmental skeletal disorder. It comprises a fibrous matrix with immature bone tissue surrounded by osteoblasts, typically located in the cortex of long bones. Distinguishing between osteofibrous dysplasia, fibrous dysplasia, classical adamantinoma, and osteofibrous dysplasia-like adamantinoma can pose a diagnostic challenge. OFD is challenging to diagnose on histopathology alone without radiological and clinical correlation and we highlight the importance of the same. Therefor

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Lusyana Nur, Liesna, and Nur Fitri Widya Astuti. "Asuhan gizi pada pasien malignant neoplasma di RSD dr. Soebandi Jember." Jurnal SAGO Gizi dan Kesehatan 4, no. 2 (2023): 265. http://dx.doi.org/10.30867/gikes.v4i2.1152.

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Background: tumor disease is a deadly disease in the world. It is estimated that around 1,300 people die each year from bone tumors. Bone tumors occur due to abnormal growth of mesenchymal cells in bones, which can be malignant/cancerous. Malignant soft tissue tumors can affect anyone, especially the elderly. In developing bone tumor malignancy, it is necessary to have nutritional service assistance that can support the nutritional adequacy of sufferers.Purpose: to determine the effect of nutritional care process on the development of the malignant neoplasma patient's condition.Methods: this s

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Ermolaev, A. Yu, A. V. Yarikov, A. Ya Aleynik, et al. "Surgical methods in management of metastatic spinal cord lesions." Russian journal of neurosurgery 24, no. 2 (2022): 78–93. http://dx.doi.org/10.17650/1683-3295-2022-24-2-78-93.

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Malignant neoplasms remain the leading cause of death worldwide. The spine is a target for metastasis more often than other skeletal bones. This article details the principles of diagnosis, treatment, and the clinical picture of secondarylesions of the spinal column. The causes of pain syndrome in cancerous lesions of the spine are reviewed: compression of nerve structures, pathological fractures, spinal instability, lytic foci and paraneoplastic pain syndrome. The causes and patterns of each type of pain syndrome are described in detail. The article presents the scales used to predict the lif

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Hoshi, Isao, Ryosuke Abe, Kei Onodera, et al. "Osteosarcoma of the Mandible in an Elderly Patient." Case Reports in Dentistry 2022 (March 17, 2022): 1–5. http://dx.doi.org/10.1155/2022/2622551.

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Osteosarcoma is a malignant tumor in which the cancerous cells produce an osteoid matrix or mineralized bone. Jaw bones are affected in 6% of all osteosarcomas and are the fourth most common site of origin. Surgical treatment of osteosarcoma in elderly patients is rarely reported. Here, we report successful treatment of osteosarcoma arising in the mandible of a 90-year-old man. The patient was referred to our institution for diagnosis and treatment of an oral lesion. Intraoral examination revealed that a hard mass measuring 35 × 27 mm was located on the floor of the oral cavity, attached to th

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Andaluz López, Brigithe Nicole, Edgar Leonardo Maldonado Samaniego, Alisson Nicole Salavarría Tutivén, et al. "Unusual Pathology Presentation, Chondroblastic Osteosarcoma of the Right Calcaneal Bone." Salud, Ciencia y Tecnología 5 (April 4, 2025): 1216. https://doi.org/10.56294/saludcyt20251216.

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Introduction: tumors that form in the bones of the foot are considered an uncommon or unusual finding in the medical setting. In most cases, the tumors are identified incidentally through imaging studies, and are generally classified as benign, meaning that they are not cancerous and do not pose a significant health risk. However, it is important to exercise appropriate caution, as these malignant bone tumors, which can form in the calcaneus, are particularly aggressive in nature and require specialized care. Lesions that are considered malignant tend to manifest themselves with increased freq

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Ashar Pambudi, Radian. "DIAGNOSTIC ACCURACY OF CONTRAST-ENHANCED ULTRASOUND TO DIFFERENTIATE BENIGN AND MALIGNANT BREAST LESIONS." Journal of Advance Research in Medical & Health Science (ISSN: 2208-2425) 9, no. 4 (2023): 53–58. http://dx.doi.org/10.53555/nnmhs.v9i4.1654.

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Cancer of the breast is caused by a cluster of abnormal breast cells that continue to divide and spread throughout the breast. These cells eventually aggregate as a lump in the affected breast. If the cancerous tumor is not treated, the cancer cells may spread to other areas of the body through a process known as metastasis. A metastasis may develop in the lymph nodes located in the axilla or those located above the scapula. In addition, cancer cells have the ability to colonize the bones, lungs, liver, skin, and even the space directly under the skin. Cancer of the breast tissue is a malignan

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Lazzini, Gianmarco, and Mario D’Acunto. "Chondrogenic Cancer Grading by Combining Machine and Deep Learning with Raman Spectra of Histopathological Tissues." Applied Sciences 14, no. 22 (2024): 10555. http://dx.doi.org/10.3390/app142210555.

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Raman spectroscopy (RS) is a promising tool for cancer diagnosis. In particular, in the last years several studies have demonstrated how the diagnostic performances of RS can be significantly improved by employing machine learning (ML) algorithms for the interpretation of Raman-based data. Recently, it has been demonstrated that RS can perform an accurate classification of chondrosarcoma tissues. Chondrosarcoma is a cancer of bones, that can occur in the soft tissues near the bones. It is normally characterized by three different malignant degrees and a benign counterpart, knows as enchondroma

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Lambring, Christoffer B., Khadiza Zaman, Elin Stone, et al. "Abstract 7053: Proteomics and integrative pathway analysis to understand the mechanism of action of mithramycin and etoposide combination induced cell death in Ewing sarcoma cells." Cancer Research 85, no. 8_Supplement_1 (2025): 7053. https://doi.org/10.1158/1538-7445.am2025-7053.

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Abstract Ewing’s sarcoma (ES) is a highly aggressive cancer that primarily originates in the bones or soft tissues and is predominantly diagnosed in adolescents and young adults. The EWS-FLI1 fusion protein is considered a hallmark of ES, being expressed in approximately 85% of cases. Prognosis for advanced ES remains poor, with survival rates around 30%, and current chemotherapy regimens are associated with severe long-term side effects. Mithramycin has emerged as a promising inhibitor of EWS-FLI1; however, its clinical application is limited by dose-dependent toxicities. We hypothesize that

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Bhandari, Hitesha, Ashwini M. Patil, Prathamesh M. Pawar, et al. "A peak into metastatic Leydig cell tumor: a rare case report." International Journal of Research in Medical Sciences 12, no. 6 (2024): 2150–53. http://dx.doi.org/10.18203/2320-6012.ijrms20241579.

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Testicle tumors are a rare entity among men population, comprising 1-1.5% of all cancers. The Sex cord Stromal tumors contribute just 4% of all testicular cancers, only 10% of them are malignant. Most common sex cord-stromal tumors are the Leydig cell tumor, comprising of 75 to 80% of the total. Incidence is bimodal involving children and adults between 30 and 60 years. The commonest metastatic sites are regional lymph nodes, lung, liver, and bones. Here, we report a case of late metastatic relapsed Leydig cell tumor in a 38-year-old male. Patients with metastatic Leydig cell tumors have poor

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15

Chauhan, Saurabh, and KK Pandey. "Role of Herbal Analgesic Drugs and Their Clinical Applications In Osteosarcoma Induced Pain." Role of Herbal Analgesic Drugs and Their Clinical Applications In Osteosarcoma Induced Pain 12, no. 2 (2022): 16–41. https://doi.org/10.5281/zenodo.6659372.

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Recently, there has been a rapid rise in deforming problems like cancer, in which bone cancer is a problem that takes a long time to move. Primary bone sarcomas are rare tumors, comprising approximately 0.2% of all cancers. Their true incidence is difficult to estimate because of their rarity.<sup>1</sup> Osteosarcoma, chondrosarcoma, and Ewing sarcoma/primitive neuroectodermal tumor are the common bone sarcomas, as per Western data, with rare tumors such as fibrosarcomas, chordomas, and undifferentiated pleomorphic sarcoma constituting as the remaining subtypes. Bone sarcomas constitute as th

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16

Guo, Wen, Haitao Jiang, Haijun Li, et al. "LncRNA-SRA1 Suppresses Osteosarcoma Cell Proliferation While Promoting Cell Apoptosis." Technology in Cancer Research & Treatment 18 (January 1, 2019): 153303381984143. http://dx.doi.org/10.1177/1533033819841438.

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Objective: Osteosarcoma is a common malignant bone tumor that is frequently found in the long bones of children and adolescents. The aim of this study is to examine long noncoding RNA-steroid receptor RNA activator 1 expression in osteosarcoma to explore the biological function of long noncoding RNA steroid receptor RNA activator 1 on proliferation, migration, and invasion along with apoptosis and its regulatory mechanism, which would facilitate the early diagnosis and targeted therapy of osteosarcoma. Methods: First, microarray analysis was applied to determine the expression of long noncodin

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Sagartz, J. E., W. L. Bodley, R. M. Gamblin, C. G. Couto, L. A. Tierney, and C. C. Capen. "p53 Tumor Suppressor Protein Overexpression in Osteogenic Tumors of Dogs." Veterinary Pathology 33, no. 2 (1996): 213–21. http://dx.doi.org/10.1177/030098589603300211.

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Alterations in the p53 tumor suppressor gene have been implicated in the genesis and/or progression of the majority of human cancers, including osteosarcoma. Stabilization of the protein by mutation or interaction with other proteins prolongs its half-life, rendering it detectable by immunohistochemistry. Osteosarcoma is the most common primary canine bone tumor and is characterized by frequent early metastases. Multilobular tumors of bone involve primarily flat bones of the head and are low-grade malignancies with lower metastatic potential. The objectives of this study were to determine the

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Lo Iacono, Giorgio, Antonio Mazzella, Shehab Mohamed, et al. "The Role of Surgery in Primary Chest Wall Tumors: Over 20 Years’ Experience in Resection and Reconstruction." Cancers 15, no. 7 (2023): 2153. http://dx.doi.org/10.3390/cancers15072153.

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Background: Primary chest wall tumors comprise a heterogeneous group of neoplasms arising from soft tissues and bones. While surgical excision is the standard of care for benign tumors, the management of malignant tumors requires multimodal treatment. We conducted a predictive analysis of outcome, recurrence-free and overall survival. Methods: We retrospectively reviewed the clinical and pathological records of all patients treated in our center between 1998 and 2020. Results: 53 patients (15–85 years) were treated in our department. The average tumor diameter was 65 ± 35 mm (10–160 mm). Negat

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He, Aina, Songhai Tian, Oded Kopper, et al. "Targeted inhibition of Wnt signaling with a Clostridioides difficile toxin B fragment suppresses breast cancer tumor growth." PLOS Biology 21, no. 11 (2023): e3002353. http://dx.doi.org/10.1371/journal.pbio.3002353.

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Wnt signaling pathways are transmitted via 10 homologous frizzled receptors (FZD1-10) in humans. Reagents broadly inhibiting Wnt signaling pathways reduce growth and metastasis of many tumors, but their therapeutic development has been hampered by the side effect. Inhibitors targeting specific Wnt-FZD pair(s) enriched in cancer cells may reduce side effect, but the therapeutic effect of narrow-spectrum Wnt-FZD inhibitors remains to be established in vivo. Here, we developed a fragment of C. difficile toxin B (TcdBFBD), which recognizes and inhibits a subclass of FZDs, FZD1/2/7, and examined wh

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Gajanin, Radoslav, Aleksandar Guzijan, Vesna Gajanin, Igor Sladojevic, and Zelimir Eric. "Jejunal tumor made of primary gastrointestinal stromal tumor and metastatic breast carcinoma - an extremely rare case." Srpski arhiv za celokupno lekarstvo 145, no. 9-10 (2017): 516–21. http://dx.doi.org/10.2298/sarh161107089g.

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Introduction. The occurrence of synchronous or metachronous malignant epithelial and mesenchymal tumors is rare. Infiltrating ductal breast cancer rarely produces metastasis in the gastrointestinal tract, and when it does, it represents a significant differential diagnostic problem. Morphologically, they can mimic primary cancers localized in the gastrointestinal tract or peritoneum. Case outline. In this paper, we present a female patient with primary, synchronous bilateral breast cancer, which after five years of follow-up had given metastases to the lungs, bones, peritoneum and mesentery, a

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Faramarzi, Negar, Sumit Sohal, Roshanak Habibi, and Muhammad Sikander Akbar. "A Complex Cardiac Mass Originating from Interatrial Septum in a Patient with History of Kidney Cancer: A Case Report and Literature Review." Case Reports in Cardiology 2018 (May 31, 2018): 1–3. http://dx.doi.org/10.1155/2018/1764057.

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Cardiac tumors are a rare phenomenon, and most cases are secondary to metastatic cancers rather than primary tumors. Renal cell carcinoma (RCC) is notorious for metastasis to cardiac tissue. Tumor thrombus migration to the renal vein and inferior vena cava happens in up to 10% of patients with RCC. Transitional cell carcinomas are another form of renal cancer, which may metastasize to the heart and are associated with widespread metastasis. Here, we report a patient with a past medical history of metastatic transitional cell cancer of renal pelvis under treatment with checkpoint inhibitor ther

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Huri, Gazi. "An Atypical Metastasis of Follicular-Type Adenocarcinoma of the Thyroid Gland to Thumb." Case Reports in Orthopedics 2011 (2011): 1–3. http://dx.doi.org/10.1155/2011/735789.

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Bone metastasis in the hand is rare. The etiology of metastatic hand cancers is different from other bones. Bronchogenic carcinoma is the most common primary tumor metastasis to hand. In this paper a rare case of thumb metastasis from “follicular-type carcinoma” of the thyroid is presented.

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Morales-Molina, Alvaro, Stefano Gambera, Angela Leo, and Javier García-Castro. "Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma." Journal for ImmunoTherapy of Cancer 9, no. 3 (2021): e001703. http://dx.doi.org/10.1136/jitc-2020-001703.

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BackgroundOsteosarcoma is the most common malignant solid tumor that affects bones, however, survival rates of patients with relapsed osteosarcoma have not improved in the last 30 years. Oncolytic virotherapy, which uses viruses designed to selectively replicate in cancer cells, has emerged as a promising treatment for solid tumors. Our group uses mesenchymal stem cells (MSCs) to transport oncolytic adenoviruses (OAds) to the tumor site, a therapeutic strategy called Celyvir. This treatment has been already applied in human patients, canine patients and different mouse models. In parallel, pre

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Kim, Seul Gi, Benny Ryplida, Pham Thi My Phuong, et al. "Reduction-Triggered Paclitaxel Release Nano-Hybrid System Based on Core-Crosslinked Polymer Dots with a pH-Responsive Shell-Cleavable Colorimetric Biosensor." International Journal of Molecular Sciences 20, no. 21 (2019): 5368. http://dx.doi.org/10.3390/ijms20215368.

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Herein, we describe the fabrication and characterization of carbonized disulfide core-crosslinked polymer dots with pH-cleavable colorimetric nanosensors, based on diol dye-conjugated fluorescent polymer dots (L-PD), for reduction-triggered paclitaxel (PTX) release during fluorescence imaging-guided chemotherapy of tumors. L-PD were loaded with PTX (PTX loaded L-PD), via π–π stackings or hydrophobic interactions, for selective theragnosis by enhanced release of PTX after the cleavage of disulfide bonds by high concentration of glutathione (GSH) in a tumor. The nano-hybrid system showed fluores

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Hu, Jamie K., Hee-Won Suh, Munibah Qureshi, et al. "Nonsurgical treatment of skin cancer with local delivery of bioadhesive nanoparticles." Proceedings of the National Academy of Sciences 118, no. 7 (2021): e2020575118. http://dx.doi.org/10.1073/pnas.2020575118.

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Keratinocyte-derived carcinomas, including squamous cell carcinoma (SCC), comprise the most common malignancies. Surgical excision is the therapeutic standard but is not always clinically feasible, and currently available alternatives are limited to superficial tumors. To address the need for a nonsurgical treatment for nodular skin cancers like SCC, we developed a bioadhesive nanoparticle (BNP) drug delivery system composed of biodegradable polymer, poly(lactic acid)-hyperbranched polyglycerol (PLA-HPG), encapsulating camptothecin (CPT). Nanoparticles (NPs) of PLA-HPG are nonadhesive NPs (NNP

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Barnes, Danielle, Meredith Herman, Nahimarys Hernandez, Brooke Koltz, David Sohn, and Jacob Maier. "Poster 110: Depth of Tissue Necrosis Following Footprint Preparation with Arthroscopic Radiofrequency Ablation." Orthopaedic Journal of Sports Medicine 10, no. 7_suppl5 (2022): 2325967121S0067. http://dx.doi.org/10.1177/2325967121s00671.

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Objectives: Successful rotator cuff repair depends upon both secure fixation and biologic integration at the bone-tendon interface. Viable osteocytes and sound bony architecture contribute to the mechanical stability of suture anchor repair constructs. Furthermore, because tendons are hypovascular, preserving the microvasculature of the underlying bone bed is important. To create the bone-tendon interface, shoulder surgeons typically employ three different techniques to clear soft tissue from the footprint prior to rotator cuff repair: mechanical debridement, radiofrequency coagulation, and ra

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Shafi, Ahmed Mohamed Abdel, Sarah Fendius, and Wael Ibrahim Awad. "Ewing sarcoma of the rib presenting with hemothorax." Asian Cardiovascular and Thoracic Annals 27, no. 9 (2019): 779–81. http://dx.doi.org/10.1177/0218492319858560.

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Ewing sarcoma is a malignant primitive neuroectodermal tumor, primarily affecting the long bones in young children and adolescents. It is a rare disease but is the most common malignancy of the chest wall, accounting for 6%–16% of chest wall cancers. We report a case of Ewing sarcoma of the rib presenting with massive hemothorax in a teenage boy, with rapid disease progression.

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Kähkönen, Tiina E., Mari I. Suominen, Jenni H. E. Mäki-Jouppila, et al. "Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone." Journal of Immunology Research 2019 (May 9, 2019): 1–10. http://dx.doi.org/10.1155/2019/4260987.

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Bone metastases are prevalent in many common cancers such as breast, prostate, and lung cancers, and novel therapies for treating bone metastases are needed. Human immune system-engrafted models are used in immuno-oncology (IO) studies for subcutaneous cancer cell or patient-derived xenograft implantations that mimic primary tumor growth. Novel efficacy models for IO compounds on bone metastases need to be established. The study was performed using CIEA NOG (NOG) mice engrafted with human CD34+ hematopoietic stem cells (huNOG) and age-matched immunodeficient NOG mice. Bone phenotyping was perf

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Gomez-Brouchet, Anne, Claire Illac, Adeline Ledoux, et al. "Sphingosine Kinase-1 Is Overexpressed and Correlates with Hypoxia in Osteosarcoma: Relationship with Clinicopathological Parameters." Cancers 14, no. 3 (2022): 499. http://dx.doi.org/10.3390/cancers14030499.

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The Sphingosine kinase-1/Sphingosine 1-Phosphate (SphK1/S1P) signaling pathway is overexpressed in various cancers, and is instrumental for the adaptation to hypoxia in a number of solid tumor models, but no data are available in osteosarcoma. Here we report that SphK1 and the S1P1 receptor are involved in HIF-1α accumulation in hypoxic osteosarcoma cells. FTY720 (Fingolimod), which targets SphK1 and S1P1, prevented HIF-1α accumulation, and also inhibited cell proliferation in both normoxia and hypoxia unlike conventional chemotherapy. In human biopsies, a significant increase of SphK1 activit

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Yu, Hui, Hua Bao, Yulin Wei, et al. "Genomic characterization of metastatic lung cancers." Journal of Clinical Oncology 38, no. 15_suppl (2020): 9584. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.9584.

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9584 Background: Lung carcinomas are most often diagnosed at stage IV, with metastases, which contribute to 90% of deaths of patients. Enormous efforts have been made in previous studies in seek of underlying mechanisms and treatments that prevent or cure metastases. However, few comprehensive conclusions have been drawn on organ-specific genomic landscapes and molecular dependencies of lung cancer metastases, largely due to limited sample sizes. Methods: We employed massive targeted next generation sequencing (NGS) with a panel covering 425 cancer-related genes on 10409 samples from 8619 pati

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Tanaka, Mai, Samantha S. Dykes, and Dietmar W. Siemann. "Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling." Clinical & Experimental Metastasis 38, no. 3 (2021): 321–35. http://dx.doi.org/10.1007/s10585-021-10093-z.

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AbstractApproximately 90% of cancer-related deaths result from cancer metastasis. In prostate and breast cancers, bone is the most common site of cancer cell dissemination. Key steps in the metastatic cascade are promoted through upregulation of critical cell signaling pathways in neoplastic cells. The present study assessed the role of the receptor tyrosine kinase Axl in prostate and breast cancer cell metastasis to bones using (i) Axl knockdown neoplastic cells and osteoclast progenitor cells in vitro, (ii) intracardiac injection of Axl knockdown tumor cells in vivo, and (iii) selective Axl

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Kushchayev, Sergiy V., Yevgeniya S. Kushchayeva, Sri Harsha Tella, Tetiana Glushko, Karel Pacak, and Oleg M. Teytelboym. "Medullary Thyroid Carcinoma: An Update on Imaging." Journal of Thyroid Research 2019 (July 7, 2019): 1–17. http://dx.doi.org/10.1155/2019/1893047.

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Medullary thyroid carcinoma (MTC), arising from the parafollicular C cells of the thyroid, accounts for 1–2% of thyroid cancers. MTC is frequently aggressive and metastasizes to cervical and mediastinal lymph nodes, lungs, liver, and bones. Although a number of new imaging modalities for directing the management of oncologic patients evolved over the last two decades, the clinical application of these novel techniques is limited in MTC. In this article, we review the biology and molecular aspects of MTC as an important background for the use of current imaging modalities and approaches for thi

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Sharmin, Rahima Akter, Sharmin Quddus, Fatema Tuz Zohra, et al. "Distribution of Skeletal Metastases in Common Malignant Tumors: Observational Study at INMAS, Mohakhali." Bangladesh Journal of Nuclear Medicine 28, no. 1 (2025): 125–29. https://doi.org/10.3329/bjnm.v28i1.79540.

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Background: Bone scan is a sensitive method for detecting bone metastases but not very specific. This means it can identify most cases of bone metastases but may also show false positives due to other conditions like arthritis or healing fractures (1). However, combining clinical data with bone scan results helps doctors narrow down thepossible causes. The study aims to investigate how common cancers spread to bones using 99m Technetium-Methyl Diphosphonate ( 99m Tc-MDP). Study design: Single-center-based retrospective study Patients and Methods: 181 consecutive patients with malignancy (prost

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Engin, H., S. Ozdamar, B. Gun, et al. "Epidemiological data of cancer of the only cancer center of the western Black Sea region of Turkey." Journal of Clinical Oncology 24, no. 18_suppl (2006): 16041. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.16041.

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16041 Background: 600 patients diagnosed as having cancer between years 2000–2005 at Zonguldak Karaelmas University were evaluated. Methods: All information pertaining to patient characteristics were retrieved from files of the Pathology and Medical Oncology Departments. Results: 383 (63,83%) were male and 217 (36,17%) were female. The most common malignancies among males are; prostate cancer 21,40 %, stomach cancer 14,62%, tumors of the bronchi and the lungs 12,10%, colorectal cancers 10,70%, skin tumors (non-melanoma 8,90%, melanoma 1,30%), malignancies of the lymphatic and hematopoietic sys

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Prokhorov, S. N., N. V. Kochergina, A. D. Ryzhkov, A. S. Krylov, and A. B. Bludov. "The Apparent Diffusion Coefficient in the Diagnosis of Metastatic Lesions of Skeletal Bones." MEDICAL RADIOLOGY AND RADIATION SAFETY 68, no. 6 (2023): 80–85. http://dx.doi.org/10.33266/1024-6177-2023-68-6-80-85.

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Aim: To evaluate the possibilities of absolute and relative values of the apparent diffusion coefficient (ADC) in the diagnosis of metastatic lesions of skeletal bones. Material and methods: The study included 12 patients with metastatic bone lesions, before any treatment was applied. The age of the patients ranged from 38 to 73 years, 3 men, 9 women. Among the morphological forms of tumors were presented: cancers of the breast (3), prostate (1) glands, colon (1), lung (2), body (1) and cervix (1) uterus, thyroid (1) and pancreas (2). The detected changes were classified on the basis of Bone s

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Wagner, Eric R., Gaurav Luther, Gaohui Zhu, et al. "Defective Osteogenic Differentiation in the Development of Osteosarcoma." Sarcoma 2011 (2011): 1–12. http://dx.doi.org/10.1155/2011/325238.

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Osteosarcoma (OS) is associated with poor prognosis due to its high incidence of metastasis and chemoresistance. It often arises in areas of rapid bone growth in long bones during the adolescent growth spurt. Although certain genetic conditions and alterations increase the risk of developing OS, the molecular pathogenesis is poorly understood. Recently, defects in differentiation have been linked to cancers, as they are associated with high cell proliferation. Treatments overcoming these defects enable terminal differentiation and subsequent tumor inhibition. OS development may be associated w

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Dit Bettoni, Romain Roth, Nicolas Hoffmann, Jordan Longin, Peggy Provent, Ismahene Benzaid, and Marc Hillairet De Boisferon. "Abstract 3916: Breast cancer brain metastasis development induced by intracarotid injection of MDA-MB 231 human breast cancer cells in mice." Cancer Research 85, no. 8_Supplement_1 (2025): 3916. https://doi.org/10.1158/1538-7445.am2025-3916.

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Abstract Breast cancer is the most common malignancy in women worldwide. Breast cancer can be divided into four types based on molecular subtypes: luminal A, luminal B, human epidermal growth factor receptor 2 (Her2) positive, and triple negative breast cancer (TNBC). These subtypes have very different prognoses and treatment methods. Herceptin, a treatment specifically directed against Her2 (overexpressed in 20–25% of breast cancers), has been widely used and improves the prognosis for Her2-positive breast cancer. TNBC accounts for only 15–20% of breast cancers and is considered as the most a

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Uruc, Fatih, Serkan Akan, Aytaç Sahin, Caglar Yildirim, and Ahmet Urkmez. "Contralateral Ovarian Metastasis of Clear-Cell Renal Carcinoma: A Rare Case Report and Review of the Literature." Case Reports in Surgery 2017 (2017): 1–3. http://dx.doi.org/10.1155/2017/9849205.

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Renal cell carcinoma (RCC) constitutes 2-3% of all types of cancers. RCCs metastasize into lungs (50–60%), lymph nodes (36%), bones (30–40%), liver (30–40%), and brain (5%) in respective percentages. RCC rarely metastasizes into ovary. Only 25 cases of ovarian tumor, which metastasized into kidneys, have been presented. In the literature, a kidney-ovary axis has been defined, and its interrelationship begins with embryological life. With this case report, we aimed both to present a very rarely seen metastasis of RCC into contralateral ovary and also to review the literature.

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Gurney, Howard, Dhanusha Sabanathan, David Gillatt, et al. "MILGa-01: A first-in-human study assessing the safety and tolerability of chMIL-38 in metastatic prostate, bladder, and pancreatic cancers." Journal of Clinical Oncology 35, no. 6_suppl (2017): e565-e565. http://dx.doi.org/10.1200/jco.2017.35.6_suppl.e565.

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e565 Background: Metastatic or recurrent cancer continues to be a challenge in patients with urogenital and pancreatic cancers despite the development of newer anti-androgen therapies. MIL-38 is an IgG1 murine monoclonal antibody directed against Glypican-1 (GPC-1). The proteoglycan GPC-1 is upregulated in prostate, pancreatic and bladder cancer cell lines. Targeting of tumor xenografts and lack of adverse events in pre-clinical models suggest chimeric MIL-38 (chMIL-38) is a good candidate for both radioimmunotherapy and antibody-drug conjugate development. Methods: Patients with known metasta

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Durakiewicz, Marek, Mirosław Jabłoński, and Aneta Zarębska. "Romuald Węgłowski (1876-1935) – Orthopaedic Surgeon, Forgotten Pioneer of Limb Saving Tumour Surgery." Ortopedia Traumatologia Rehabilitacja 19, no. 2 (2017): 191–200. http://dx.doi.org/10.5604/15093492.1238036.

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On May 16, 1914, The Lancet Journal published a paper by Romuald Węgłowski, a Polish-born professor of Moscow University, entitled „Malignant tumours of bones: a new method in conservative operative treatment.” The idea of biological resection presented in the paper consisted in thermocoagulation of the apparently cancerous part of a bone with a jet of steam. According to the author, dead bone rid of live malignant cells reconstructed itself quickly, which helped to preserve the functionality of the organ without considerable limitations. The events of the First World War, political changes in

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S., Amouzoune F. Boukis C.Ahouissoussi N. Mansouri N. Hachmane K.Harou A. Soumani H. El Mansouri N.C.I. Guennouni F. . Benadra H. Rais. "Papillary Thyroid Carcinoma Metastasis to the Breast and Axillary Lymph Nodes: A Case Report With Literature Review." British Journal of Pharmaceutical and Medical Research 4, no. 2 (2019): 10.24942/bjpmr.2019.465. https://doi.org/10.24942/bjpmr.2019.465.

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Papillary carcinomas of the thyroid (PCT) are the most common type of well differentiated cancers. These cancers usually remain localized in the thyroid gland. Distant metastases are rare and usually occur in advanced disease, usually in lungs, bones. Metastases to the breast are uncommon. We present a case of 84 years women who had a total thyroidectomy for a papillary thyroid carcinoma 11 years ago. She  presented lump in left breast.  Mammography revealed a well defined, soft tissue confluent densities in the inner and lower left quadrant with irregular borders. The biopsy of brea

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Zhao, Yanqiu, Yang Zou, Xunxun Deng, Hanwen Wang, and Shuo Wu. "Fabrication of Small Multifunctional CuS Nanoclusters for Fluorescence Imaging and Chemo-Photothermal Therapy of Cancer." Nano 15, no. 09 (2020): 2050123. http://dx.doi.org/10.1142/s1793292020501234.

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A multifunctional nanodrug, PAMAM@CuS-HA-RB/DOX, was prepared for the real time tracking and chemo-photothermal therapy of tumor cells. The CuS nanoclusters with diameter less than 10[Formula: see text]nm could be easily ingested by tumor cells and showed good colloid stability and high photothermal conversion efficiency. The hyaluronic acid (HA) coating and rhodamine B (RB) labeling endowed the nanocomposite with low cytotoxity and real time fluorescence imaging ability. In the acidic tumor microenvironment, the doxorubicin linked via the pH-responsive hydrazone bonds was released and worked

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Mohan, Abbi. "Advances in Nanotechnology for Diagnosis, Treatment, and Recovery of Bone Cancer." Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal 9, no. 6 (2025): 1–7. https://doi.org/10.26685/urncst.886.

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Introduction: Although effective treatments for bone cancer currently exist, nanotechnology promises to improve the diagnosis, treatment, and recovery from this disease. This paper explores the various ways in which nanotechnology is being explored in relation to the imaging of tumours, the delivery of treatments, and the rebuilding of bones. Methods: Using computer aided searches, studies from across the globe that highlighted the development of nanotechnology for application in treating bone cancers were located. A total of ten articles were selected for inclusion in this paper because they

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Joseph, Dr Liz Maria, and Dr Sankar S. "Papillary Thyroid Carcinoma with Lung Metastasis after 31 Years: A Case Report." East African Scholars Journal of Medical Sciences 5, no. 3 (2022): 84–87. http://dx.doi.org/10.36349/easms.2022.v05i03.002.

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Thyroid cancers are the most common endocrine malignant tumors. Papillary thyroid cancer (PTC) is the most common histological type of differentiated thyroid cancer (DTC), accounting for 90% of thyroid cancers. PTC commonly metastasizes to regional lymph nodes. However, distant metastasis may rarely occur and accounts for 5% of the patients. The lungs and the bones are the most common sites for distant metastasis. Major risk factors for PTC include radiation exposure, insufficient or excess dietary iodine, Cowden’s disease, Gardner’s syndrome and dyshormonogenetic goiter. The serum thyroglobul

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Muhammad Waqas, Tanzil Sajid, and Mairah Razi. "Metastatic PSMA avid prostate tumour with penile uptake; a rare metastatic site on PET-CT." Journal of the Pakistan Medical Association 74, no. 2 (2024): 407–8. http://dx.doi.org/10.47391/jpma.24-12.

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Prostate carcinoma is the most common malignancy in males and the second most common cause of mortality. Initially, metastatic prostate cancers tend to involve bones, but these tumours can involve any system. Gallium-68 prostate specific membrane antigen (PSMA) positron emission computed tomography (PET-CT) scan is indicated in prostate cancer patients if PSA levels are raised, and CT and bone scans are inconclusive. Metastatic penile involvement is a rare phenomenon. We present a case of prostate cancer with foci of PSMA uptake in the penile region. Key Words: Ga68-PSMA PET-CT scan, Penile, P

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Pompili, Stefano Vito Boccadamo, Sophia Fanzini, Melitta Schachner, and Suzie Chen. "In Vitro and In Vivo Studies of Melanoma Cell Migration by Antagonistic Mimetics of Adhesion Molecule L1CAM." International Journal of Molecular Sciences 25, no. 9 (2024): 4811. http://dx.doi.org/10.3390/ijms25094811.

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Melanoma, the deadliest type of skin cancer, has a high propensity to metastasize to other organs, including the brain, lymph nodes, lungs, and bones. While progress has been made in managing melanoma with targeted and immune therapies, many patients do not benefit from these current treatment modalities. Tumor cell migration is the initial step for invasion and metastasis. A better understanding of the molecular mechanisms underlying metastasis is crucial for developing therapeutic strategies for metastatic diseases, including melanoma. The cell adhesion molecule L1CAM (CD171, in short L1) is

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Weeraratne, Dilhan, Elisa Napolitano Ferreira, Miguel Mitne Neto, et al. "Comprehensive analysis of advanced-stage solid tumors from TCGA reveal widespread variation of genomics evidence levels across cancer types." Journal of Clinical Oncology 38, no. 15_suppl (2020): e13547-e13547. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e13547.

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e13547 Background: Improved scalability and affordability of next generation sequencing (NGS) has pivoted cancer care toward genomics-driven treatment decisions. Particularly in advanced-stage or refractory cancer, clinical insights gleaned from NGS have become an integral option as these patients have typically exhausted all lines of available therapy. As precision oncology evolves, NGS is expected to have a differential impact based on the cancer type. In this study, a comprehensive NGS panel was used to determine the strength of clinical evidence in various advanced stage tumor samples from

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Martano, Marina, Emanuela Morello, Sofia Avnet, et al. "Photodynamic Surgery for Feline Injection-Site Sarcoma." BioMed Research International 2019 (July 8, 2019): 1–9. http://dx.doi.org/10.1155/2019/8275935.

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Musculoskeletal sarcomas are rare and aggressive human malignancies affecting bones and soft tissues with severe consequences, in terms of both morbidity and mortality. An innovative technique that combines photodynamic surgery (PDS) and therapy (PDT) with acridine orange has been recently suggested, showing promising results. However, due to the low incidence of sarcoma in humans, this procedure has been attempted only in pilot studies and stronger evidence is needed. Naturally occurring tumors in cats are well-established and advantageous models for human cancers. Feline injection-site sarco

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Menotti, Vinicius Stela, Ricardo Alexandre Spironello, Fabiane Cocco Salvadego, et al. "Therapeutic strategies and clinical evolution in pediatric fibrosarcoma: a case report." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 22, no. 8 (2024): e6292. http://dx.doi.org/10.55905/oelv22n8-131.

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Congenital infantile fibrosarcoma (IFS) is rare and represents less than 1% of all childhood cancers. It is a tumor that originates in the connective fibrous tissue found at the ends of long bones and then spreads to other surrounding soft tissues. These lesions are typically large, grow rapidly, and diagnosis is confirmed by histopathology, where cellular proliferation of fibroblasts occurs. The surgical resection is the primary treatment; however chemotherapeutic agents may be used as adjuvant therapy. We herein report IFS in the arm of child patient, who had a large localized tumoral mass w

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Saiki, Masafumi, Fumiyoshi Ohyanagi, Ryo Ariyasu, et al. "Clinical and radiological features of advanced RET-rearranged lung cancer." Journal of Clinical Oncology 35, no. 15_suppl (2017): e23104-e23104. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e23104.

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e23104 Background: RET fusion gene was found in 1–2% of non-small cell lung cancer (NSCLC). Most of the reports published so far investigated only surgical specimens, and details of advanced tumors were unknown. This study explored the clinical and radiological characteristics of RET-rearranged lung cancers in advanced stages. Methods: Among 1,074 advanced NSCLC patients who were treated at The Cancer Institute Hospital, Tokyo, from 2012 to 2016, 14 cases (14/1,074 = 1.3%) were treated as RET- rearranged lung cancer. The cases were identified by FISH and / or by RT-PCR (FISH 3, RT-PCR 2, FISH

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