Relevant bibliographies by topics / Candida intermedia

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Candida intermedia'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Candida intermedia"

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Ruan, Sheng-Yuan, Jung-Yien Chien, Yi-Chung Hou, and Po-Ren Hsueh. "Catheter-related fungemia caused by Candida intermedia." International Journal of Infectious Diseases 14, no. 2 (February 2010): e147-e149. http://dx.doi.org/10.1016/j.ijid.2009.03.015.

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Moreno, Antonio D., Elia Tomás-Pejó, Lisbeth Olsson, and Cecilia Geijer. "Candida intermedia CBS 141442: A Novel Glucose/Xylose Co-Fermenting Isolate for Lignocellulosic Bioethanol Production." Energies 13, no. 20 (October 15, 2020): 5363. http://dx.doi.org/10.3390/en13205363.

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The present study describes the isolation of the novel strain Candida intermedia CBS 141442 and investigates the potential of this microorganism for the conversion of lignocellulosic streams. Different C. intermedia clones were isolated during an adaptive laboratory evolution experiment under the selection pressure of lignocellulosic hydrolysate and in strong competition with industrial, xylose-fermenting Saccharomyces cerevisiae cells. Isolates showed different but stable colony and cell morphologies when growing in a solid agar medium (smooth, intermediate and complex morphology) and liquid medium (unicellular, aggregates and pseudohyphal morphology). Clones of the same morphology showed similar fermentation patterns, and the C. intermedia clone I5 (CBS 141442) was selected for further testing due to its superior capacity for xylose consumption (90% of the initial xylose concentration within 72 h) and the highest ethanol yields (0.25 ± 0.02 g ethanol/g sugars consumed). Compared to the well-known yeast Scheffersomyces stipitis, the selected strain showed slightly higher tolerance to the lignocellulosic-derived inhibitors when fermenting a wheat straw hydrolysate. Furthermore, its higher glucose consumption rates (compared to S. stipitis) and its capacity for glucose and xylose co-fermentation makes C. intermedia CBS 141442 an attractive microorganism for the conversion of lignocellulosic substrates, as demonstrated in simultaneous saccharification and fermentation processes.
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Gárdonyi, Márk, MÃ¥ns ÖSterberg, Carla Rodrigues, Isabel Spencer-Martins, and Bärbel Hahn-Hägerdal. "High capacity xylose transport in Candida intermedia PYCC 4715." FEMS Yeast Research 3, no. 1 (March 2003): 45–52. http://dx.doi.org/10.1111/j.1567-1364.2003.tb00137.x.

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Huang, R., G. Q. Li, J. Zhang, L. Yang, H. J. Che, D. H. Jiang, and H. C. Huang. "Control of Postharvest Botrytis Fruit Rot of Strawberry by Volatile Organic Compounds of Candida intermedia." Phytopathology® 101, no. 7 (July 2011): 859–69. http://dx.doi.org/10.1094/phyto-09-10-0255.

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A study was conducted to identify volatile organic compounds or volatiles produced by Candida intermedia strain C410 using gas chromatography–mass spectrometry, and to determine efficacy of the volatiles of C. intermedia in suppression of conidial germination and mycelial growth of Botrytis cinerea and control of Botrytis fruit rot of strawberry. Results showed that, among 49 volatiles (esters, alcohols, alkenes, alkanes, alkynes, organic acids, ketones, and aldehydes) identified from C. intermedia cultures on yeast extract peptone dextrose agar, two compounds, 1,3,5,7-cyclooctatetraene and 3-methyl-1-butanol, were the most abundant. Synthetic chemicals of 1,3,5,7-cyclooctatetraene; 3-methyl-1-butanol; 2-nonanone; pentanoic acid, 4-methyl-, ethyl ester; 3-methyl-1-butanol, acetate; acetic acid, pentyl ester; and hexanoic acid, ethyl ester were highly inhibitory to conidial germination and mycelial growth of B. cinerea. Inhibition of conidial germination and mycelial growth of B. cinerea by volatiles of C. intermedia was also observed. Meanwhile, results showed that incidence and severity of Botrytis fruit rot of strawberry was significantly (P < 0.01) reduced by exposure of the strawberry fruit to the volatiles from C. intermedia cultures or C. intermedia-infested strawberry fruit. These results suggest that the volatiles of C. intermedia C410 are promising biofumigants for control of Botrytis fruit rot of strawberry.
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Jurado-Martín, Irene, Cristina Marcos-Arias, Esther Tamayo, Andrea Guridi, Piet W. J. de Groot, Guillermo Quindós, and Elena Eraso. "Candida duobushaemulonii: An Old But Unreported Pathogen." Journal of Fungi 6, no. 4 (December 17, 2020): 374. http://dx.doi.org/10.3390/jof6040374.

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Candidiasis caused by species of the Candida haemulonii complex (Candida haemulonii and Candida duobushaemulonii) and closely related species, Candida auris and Candida pseudohaemulonii are increasing. These species often show reduced susceptibility to antifungal drugs, such as azoles and amphotericin B or, less frequently, echinocandins. However, conventional phenotypic identification methods are unable to accurately differentiate these species and, therefore, their prevalence may have been underestimated. In this study, 150 isolates that were probably misidentified were reanalyzed using two novel PCR approaches. We found that one isolate previously identified in 1996 as Candida intermedia was C. duobushaemulonii, being one of the oldest isolates of this species described to date. We also found that this isolate had reduced susceptibility to fluconazole, itraconazole, and amphotericin B.
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SUTHERLAND, JOHN B., LISA A. TANNER, JENNIFER D. MOORE, JAMES P. FREEMAN, JOANNA DECK, and ANNA J. WILLIAMS. "Conversion of Ferulic Acid to 4-Vinylguaiacol by Yeasts Isolated from Frozen Concentrated Orange Juice." Journal of Food Protection 58, no. 11 (November 1, 1995): 1260–62. http://dx.doi.org/10.4315/0362-028x-58.11.1260.

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Yeasts were isolated from frozen concentrated orange juice, grown in Sabouraud dextrose broth at 25°C, and tested for the ability to cometabolize ferulic acid. Strains of Rhodotorula sp., Candida lambica, Trichosporon pullulans, and Candida intermedia decarboxylated ferulic acid nonoxidatively to an off-flavor compound, 4-vinylguaiacol. By decarboxylating naturally occurring ferulic acid, these and other yeasts have the potential to contribute to off flavors in improperly stored fruit juices.
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Loureiro-Dias, M. C. "Glucose and Polyol Transport Systems in Candida intermedia and their Regulation." Microbiology 133, no. 10 (October 1, 1987): 2737–42. http://dx.doi.org/10.1099/00221287-133-10-2737.

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Neves, Kilma Cristiane Silva, Ana Lúcia Figueiredo Porto, and Maria Francisca Simas Teixeira. "Seleção de leveduras da Região Amazônica para produção de protease extracelular." Acta Amazonica 36, no. 3 (2006): 299–306. http://dx.doi.org/10.1590/s0044-59672006000300002.

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O objetivo deste trabalho foi identificar 50 leveduras isoladas a partir de diferentes substratos da Região Amazônica e selecionar uma espécie de maior atividade proteolítica. Entre as 26 espécies identificadas predominaram Candida aquatica (12%) e Candida tropicalis (10%). A fermentação submersa foi realizada em Extrato de Malte suplementado com gelatina 1%, Candida intermedia foi a que expressou maior atividade proteolítica, halo = 25 mm e 273 U/mL, crescimento máximo a 30 ºC, viabilidade celular 6,2 x 10(6) UFC, em 48 horas, não demonstrou características de patogenicidade e a melhor densidade do inóculo foi 3%, utilizando-se culturas com 24 horas de crescimento em ágar Malte.
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UTYUZH, A., D. NIKOLENKO, A. YUMASHEV, I. VOLCHKOVA, and V. SAMUSENKOV. "ADHESION OF PERIODONTAL PATHOGENS TO MATERIALS USED FOR LONG-TERM TEMPORARY CROWNS." Periódico Tchê Química 16, no. 33 (March 20, 2019): 60–69. http://dx.doi.org/10.52571/ptq.v16.n33.2019.75_periodico33_pgs_60_69.pdf.

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Provisional crowns are widely used in prosthodontic treatment in dentistry, and new materials for temporary crowns, including polyetheretherketone, have emerged, which have high-quality requirements for use in long-term temporary prosthetics. Of particular importance in prosthetics are the features of adhesion of pathogenic oral microflora to orthodontic structures. This study evaluated the adhesion of cariogenic and pathogenic periodontal bacterial flora and Candida species to unpolished and polished Dentokeep polyetheretherketone (PEEK), polished polymethyl methacrylate (PMMA) material (Re-Fine Acrylic), and hotcuring acrylic plastic ─ a powder-liquid type, where the powder is a suspension graft fluorine-containing copolymer, and the liquid is a mixture of acrylic monomers, and oligomers─(Sinma-M) recommended for manufacturing long-term temporary crowns. The effect of polishing or un-polishing the study material on the adhesion of various microorganisms was studied. Polishing of Dentokeep PEEK significantly influenced primary adhesion. Microbial adhesion to sample materials was studied using ultrasonic cavitation. Adhesion of microorganisms to each material was categorized as low (0–0.27), moderate (0.28–0.69), or high (0.70–1). Streptococcus sanguinis, Prevotella intermedia, and Candida albicans adhered moderately to unpolished Dentokeep PEEK, whereas Porphyromonas gingivalis and Candida krusei were highly adherent. Candida species and P. intermedia pathogenic periodontal strain moderately adhered to polished Dentokeep PEEK, whereas S. sanguinis and P. gingivalis were highly adherent. Temporary crowns require additional hygienic measures to eradicate cariogenic (acidogenic), pathogenic periodontal, and fungal microbiota and maintain the normal qualitative and quantitative composition of oral microbiocenosis during prosthodontic treatment. In conclusion, PEEK is a promising material for the manufacture of long-term temporary crowns.
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Nakase, Takashi, Sasitorn Jindamorakot, Somit Am-In, Ching-Fu Lee, Yumi Imanishi, and Savitree Limtong. "Three novel species of the anamorphic yeast genus Candida in the Candida intermedia clade found in Japan, Thailand and Taiwan." Journal of General and Applied Microbiology 57, no. 2 (2011): 73–81. http://dx.doi.org/10.2323/jgam.57.73.

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Dissertations / Theses on the topic "Candida intermedia"

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Viana, Zenira Cardoso Vilasboas. "Estudo comparativo entre Candida parapsilosis var, Intermedia (IZ-A7) e leveduras naturais da"Goga"(mel de cacau), que produzem um fator com capacidade de inibir o crescimento do fungo Phytophthora capsici." Universidade de São Paulo, 1989. http://teses.usp.br/teses/disponiveis/11/11141/tde-20181127-161421/.

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A produção de massa celular de Candida parapsilosis var, Intermedia e das leveduras naturais provenientes da"goga"(mel de cacau), safra/87, foram obtidas em meio Sabouraud líquido. O crescimento das células foi interrompido com 6, 12, 24, 48, 72, 96, 120 e 144 horas consecutivas de fermentação, sendo realizados posteriormente, testes para avaliar a produção, por parte das leveduras, de um fator capaz de inibir o crescimento de P. capsici. As células foram separadas do meio fermentado por centrifugação, sendo depois rompidas com material abrasivo, sob resfriamento, separando-se a fração subcelular dos seus restos celulares. Todas as fraç6es obtidas (meio fermentado, restos celulares e fração subcelular) foram esterilizadas por autoclavagem. Os testes de inibição do crescimento de P. capsici foram conduzidos em placas de Petri contendo meio BDA, onde foram adicionadas diferentes concentraç6es do meio fermentado, de células rompidas e de fração subcelular, res- pectivamente. Estas placas foram inoculadas com P. capsici, observando-se seu crescimento durante 5 (cinco) dias consecutivos em temperatura ambiente. Os resultados obtidos mostraram que houve a produção de um fator inibidor do crescimento de P. capsici, no meio fermentado de Candida parapsilosis var, Intermedia mais acentuado até cerca de 48 horas de fermentação. Mesmo após esse período, a produção do fator de inibição se manteve ligeiramente crescente até 144 horas de fermentação nas concentrações estudadas de 1:10 e 1:5. Já para as leveduras naturais da"goga"de cacau, o fator de inibição, produzido no meio com concentração 1:10 manteve-se ligeiramente crescente de 6 a 120 horas, aumentando vigorosamente até 100% após 144 horas, o que pode ser verificado mesmo em concentrações menores como 1:20. O fator de inibição do crescimento de P. capsici, sendo produzido no interior das células no curso da fermentação, foi liberado para o meio fermentado, como pode ser demonstrado nos experimentos com frações subcelulares e restos celulares, cuja inibição foi considerada insignificante em relação ao meio fermentado
In order to reduce the"dark gray rottenness"of the cacao-tree fruits, caused by P. capsici, experiments were carried out to promote the biological control of this fungus. Its growth was accomplished in potato-dextrose-agar (PDA), showing a rapid sporulation. The production of Candida parapsilosis var, Intermedia cell mass and natural yeasts from"goga"Cacao- honey), harvest/87, were obtained in liquid Sabouraud medium. The cells growth was interrupted with 6, 12, 24, 48, 72, 96, 120 and 144 consecutive hours of fermentation; posterior tests were made to evaluate the production of an inhibition factor, by yeasts, suitable to inhibit the P. capsici, growth. The cells were separated from the fermentated medium by centrifugation, and then, they were broken with abrasive material, by cooling; the subcell fraction was separated from its cell rests. All the fractions obtained (fermentated medium, cell rests, and subcell fraction) were sterilized by autoclaving. The inhibition tests of the P. capsici, growth were conducted on Petri plates, containing PDA medium, adding different concentrations of the fermentated medium, broken cells and subcell fractions, respectively. These plates were inoculated with P. capsici, its growth was observed during five consecutive days at room temperature. The obtained results showed that there was production of a P. capsici, growth inhibitor factor Candida parapsilosis var, Intermediafermentated medium, until almost 48 hours of fermentation. Thus, after this period, the production of the inhibition factor maintained light increase until 144 hours of fermentation, at the 1:10 and 1:5 concentrations. Otherwise, the inhibition factor produced by cacao"goga"natural yeasts, in a medium with the concentration 1 :10, maintained a light increase from 6 through 12Q hours, augmenting strongly till 100%, after 144 hours, the same could be observed in concentrations smaller than 1:20. The P. capsici, growth inhibition factor produced inside the cells during the fermentation, was released to the fermentated medium, as could be demonstrated in the experiments with subcell fractions and cell rests, whose inhibition was considered insignificant in relation to the fermentated medium
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Dempster, Emma Louise. "Genetic analysis of candidate genes for schizophrenia and its intermediate phenotypes." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417105.

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Chaput, Ludovic. "Compréhension de l'énantiosélectivité de la lipase B de Candida antarctica : étude par modélisation moléculaire et expérimentation." Phd thesis, Université de La Rochelle, 2012. http://tel.archives-ouvertes.fr/tel-00825876.

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La lipase B de Candida antarctica (CALB) est un enzyme présentant des propriétés énantiosélectives très intéressantes pour l'obtention de molécules énantio pures par dédoublement cinétique de mélanges racémiques,molécules utilisées comme synthons dans l'industrie pharmaceutique. En effet, le principe actif de nombreux médicaments est efficace sous une forme énantio pure, l'autre forme chirale pouvant se révéler délétère pour l'organisme.Les travaux de la thèse s'intéressent à mieux comprendre l'origine de l'énantiosélectivité de la lipase B de Candida antarctica, en particulier pour la résolution d'alcools secondaires par des réactions de transestérification.Nous utilisons pour la première fois la méthode de la perturbation de l'énergie libre pour estimer la différence d'énergie libre entre les intermédiaires tétraédriques obtenus avec les formes R et S d'alcools énantiomères pour une série d'alcools secondaires, dans le but de prédire in silico l'énantiosélectivité de la CALB. Les paramètres cinétiques apparents d'une réaction avec deux alcools substrats énantiopurs sont expérimentalement déterminés et permettent de définir la contribution respective du Km et du kcat de chaque énantiomère pour la définition de l'énantiosélectivité. L'étude expérimentale de l'effet d'empreinte par des molécules co-substrats est réalisée,ainsi qu'une étude par modélisation moléculaire de l'effet d'empreinte par le premier ester substrat de la réaction qui pourrait modifier la conformation du site actif de la CALB. La troisième partie porte sur l'étude de la CALB et de trois variants (T42V, S47A et T42V/S47A) chez lesquels les acides aminés dans la poche stéréospécifiques ont mutés. T42V et S47A permettent d'obtenir une augmentation de l'énantiosélectivité. L'étude propose une étude détaillée de la conformation du site actif à partir de simulations de trajectoires de dynamique moléculaire
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Baars, Jan-Robert. "Biological control initiatives against Lantana camara L. (Verbenaceae) in South Africa : an assessment of the present status of the programme, and an evaluation of Coelocephalapion camarae Kissinger (Coleoptera: Brentidae) and Falconia intermedia (Distant) (Heteroptera: Miridae), two new candidate natural enemies for release on the weed." Thesis, Rhodes University, 2003. http://hdl.handle.net/10962/d1005329.

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Lantana camara (lantana), a thicket-forming shrub, a number of different varieties of which were introduced into South Africa as ornamental plants but which has become a serious invasive weed. Conventional control measures for lantana are expensive and ineffective and it has therefore been targeted for biological control since 1961. To date, eleven biological control agent species have become established on lantana in South Africa. However, most agents persist at low densities and only occasionally impact plant populations. Three species regularly cause significant damage, but only reach sufficiently high numbers by midsummer after populations crash during the winter. Overall, the impact of the biological control programme on the weed is negligible and this has been ascribed to the poor selection of agents for release, the accumulation of native parasitoids, differences in insect preference for different varieties of the weed and variable climatic conditions over the weed’s range. This study suggests that the importance of varietal preferences has been over-estimated. A predictive bioclimatic modelling technique showed that most of the agents established in South Africa have a wide climatic tolerance and that the redistribution and importation of new climatypes of these agents will not improve the level of control. Additional agents are required to improve the biocontrol in the temperate conditions, and also to increase damage in the sub-tropical areas where most of the agents are established and where the weed retains its leaves year round. New candidate agents that possess biological attributes that favour a high intrinsic rate of increase, a high impact per individual and that improve the synchrony between the weed and the agent in climatic conditions that promote the seasonal leaflessness of plants should receive prior consideration. A survey in Jamaica indicated that additional biological control agents are available in the region of origin but that care should be taken to prioritise the most effective agents. The various selection systems currently available in weed biocontrol produce contradictory results in the priority assigned to candidate agents and a new selection system is proposed. The biology and host range of two new candidate natural enemies, the leaf-galling weevil, Coelocephalapion camarae and the leaf-sucking mirid, Falconia intermedia were investigated for the biocontrol of lantana. The studies indicated that these have considerable biocontrol potential, in that the weevil has a wide climatic tolerance and has the potential to survive the host leaflessness typical of temperate conditions, while the mirid has a high intrinsic rate of increase, and the potential for several generations a year. Both agents caused a high level of damage to the leaves, with the weevil galling the vascular tissue in the leaf-petiole and the mirid causing chlorotic speckling of the leaves. During laboratory trials both agents accepted indigenous species in the genus Lippia. However, under multiple choice conditions these agents showed a significant and strong oviposition preference for lantana. A risk assessment and post release field trials indicated that F. intermedia is likely to attack some Lippia species in the presence of lantana, but the levels of damage are predicted to be relatively low. A possible low incidence of damage to indigenous species was considered a justifiable ‘trade-off’ for the potentially marked impact on L. camara. Preference and performance studies on the two candidate agents suggested that most of the South African lantana varieties are suitable host plants. The mirid preferred certain varieties in multiple choice experiments, but this is unlikely to affect its impact under field conditions. Permission for release was accordingly sought for both species. Finally, the challenges facing the biological control programme and the potential for improving the control of L. camara in South Africa are considered.
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Books on the topic "Candida intermedia"

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Edexcel, ed. Information and Communication Technology.GNVQ Intermediate Unit 1: Presenting information. Pre-Release Material. Candidate Brief. London: Edexcel, 2001.

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Information and Communication Technology.GNVQ Intermediate Unit 5: Information Resources.Pre-Release Material. Candidate Brief.January and May/June 2003. London: Edexcel, 2001.

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Book chapters on the topic "Candida intermedia"

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Donald, I. W., B. L. Metcalfe, M. E. Brenchley, and R. S. Greedharee. "Chemical Durability of Candidate Wasteforms for the Immobilisation of Chloride-Containing Intermediate Level Radioactive Wastes." In Ageing Studies and Lifetime Extension of Materials, 647–52. Boston, MA: Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1215-8_71.

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Pugh, E. N., and W. H. Cobbs. "Properties of Cytoplasmic Transmitters of Excitation in Vertebrate Rods and Evaluation of Candidate Intermediary Transmitters." In The Molecular Mechanism of Photoreception, 127–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70444-4_9.

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Pridham, Geoffrey. "The Political Arena and Intermediary Actors in Candidate Countries: Political Parties, Opinion-makers and Public Impacts." In Designing Democracy, 145–90. London: Palgrave Macmillan UK, 2005. http://dx.doi.org/10.1057/9780230504905_5.

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Gómez, Javier, and Timo Ojala. "A Mobile Navigation System Based on Visual Cues for Pedestrians with Cognitive Disabilities." In Assistive Technologies for Physical and Cognitive Disabilities, 173–90. IGI Global, 2015. http://dx.doi.org/10.4018/978-1-4666-7373-1.ch009.

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The authors present a prototype of a mobile navigation system designed for pedestrians with cognitive disabilities. The system first determines the shortest route from current location to a desired predefined destination from a set of candidate routes obtained from Bing Maps and Google Maps. Then the system extracts intermediate targets (decision points) from the route according to street crossings. The guidance to the next intermediate target is provided in the form of atomic textual and auditory instructions, together with visual cues extracted automatically from Google Street View. The experimental evaluation of the application is carried out via a field study with two subjects with Down syndrome in authentic urban setting. The chapter concludes with a reflection on the design of the system and the findings of the field study.
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"21 Exploring the World with Rockwell Kent’s Candide: Intermedial Translation, Paratextual Framing, and Iconographic Landscape 309." In Art and Science in Word and Image, 309–22. Brill | Rodopi, 2019. http://dx.doi.org/10.1163/9789004361119_023.

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Gray, Joshua C., Sandra Sanchez-Roige, Abraham A. Palmer, Harriet de Wit, and James MacKillop. "Genetics of decision-making." In Genes, brain, and emotions, 188–202. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198793014.003.0013.

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Persistent maladaptive decision-making is central to several psychiatric conditions, particularly addiction. Decision-making measures may serve as promising intermediate phenotypes (i.e. intervening mechanisms that link genetic variation to clinical vulnerability) and thus elucidate biological mechanisms that increase risk for addiction and related psychiatric disorders. This chapter focuses on the heritability and specific genetic correlates of the three most widely studied experimental measures of decision-making: impulsivity, measured by delayed reward discounting; disadvantageous decision-making, measured by the Iowa Gambling Task; and risk sensitivity, measured by the Balloon Analogue Risk Task. Despite some evidence of heritability for all phenotypes, the candidate gene studies reveal inconsistent findings. The extant literature is limited by small sample sizes, and a focus on select candidate genes, primarily related to dopaminergic and serotonergic systems. To advance the science, research will need to aggregate studies, increase sample sizes, explore subpopulations, and utilize genome-wide association studies to expand the genomic scope.
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Phelix, Clyde F., Allen K. Bourdon, Jason L. Dugan, Greg Villareal, and George Perry. "MSDC-0160 and MSDC-0602 Binding with Human Mitochondrial Pyruvate Carrier (MPC) 1 and 2 Heterodimer." In Research Anthology on Diagnosing and Treating Neurocognitive Disorders, 427–55. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-3441-0.ch022.

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The mitochondrial pyruvate carrier (MPC) is a novel target for therapeutic drugs to treat Alzheimer's and Parkinson's disease, diabetes mellitus, and non-alcoholic steatohepatitis (NASH). Metabolic Solutions Development Company (MSDC) has two thiazolidinediones, MSDC-0160 and MSDC-0602, in the pipeline. This report describes results for a MPC1/2 heterodimer homology model. The FASTA sequences for MPC1 and MPC2 were accessed from UniProt and submitted to RaptorX, resulting in best candidate monomeric “protein data base” files for each. One mutant form of MPC1, L36I, was also processed. These were submitted to PyDock to generate best candidate MPC1/2 heterodimer models that were used for ligand docking analyses with AutoDock Vina and “Rosetta Online Server that Includes Everyone” (ROSIE). Multiple binding sites for pyruvate and both drugs were found on both MPC1 and MPC2 subunits with drugs having nearly double the affinity in each case except the intermediate and open-in states for the L36I mutant transporter.
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SMILEY, CLAYTON, SHAGUN CHOPRA, and DANIEL T. O'CONNOR. "Hypertension genetics: candidate genetic loci, 'intermediate' phenotypes, and genome-wide searches for susceptibility loci." In The Year in Hypertension 2004, 153–72. CRC Press, 2004. http://dx.doi.org/10.1201/9780203500521-7.

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Gottschalk, Michael G., and Katharina Domschke. "Genetics of anxiety disorders." In New Oxford Textbook of Psychiatry, edited by John R. Geddes, Nancy C. Andreasen, and Guy M. Goodwin, 928–37. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198713005.003.0089.

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Genetics of anxiety disorders highlights recent developments in the identification of genetic variation associated with specific phobias, social anxiety disorder, agoraphobia, panic disorder, generalized anxiety disorder, and cross-disorder intermediate phenotypes like neuroticism/negative affectivity, introversion, behavioural inhibition, harm avoidance, and anxiety sensitivity. It reviews evidence gathered by family and twin studies, structural and rare variations, genome-wide association studies (GWAS), candidate genes, gene–environment, and epigenetic approaches. Special focus is placed upon functional hypotheses linked to the serotonergic and catecholaminergic, as well as neuropeptide and neurohormonal, signalling systems, followed by multi-level neurophysiological, neuroimaging, and behavioural investigations of anxiety- and fear-related traits. Special emphasis is put on dimensional psychopathology and biomarkers of disease course, susceptibility, and treatment response to cognitive behavioural therapy or psychopharmacological interventions. Moreover, challenges and perspectives are addressed related to drug discovery, personalized medicine, polygenic risk assessment, relevance to nosological domains, and plasticity of the underlying epigenetic architecture.
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Lagunas, Eva, Monica Navarro, Pau Closas, Montse Najar, Ricardo Garcia-Gutierrez, and Genís Floriach. "Position Estimation for IR-UWB Systems." In Advances in Wireless Technologies and Telecommunication, 274–316. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-3528-7.ch007.

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IR-UWB has emerged as a promising candidate for positioning passive nodes in wireless networks due to its extremely short time domain transmitted pulses. The two-step approaches in which first different TOAs are estimated and then fed into a triangulation procedure are suboptimal in general. This is because in the first stage of these methods, the measurements at distinct anchors are independent and ignore the constraint that all measurements must be consistent with a single emitter location. In this chapter, the authors investigate two techniques to overcome this issue. First, a two-step procedure based on multi-TOA estimation is proposed. Second, a positioning approach omitting the intermediate known as DPE is presented. Complementarily, the authors explore the CS-based modeling of both approaches so that the temporal sparsity of the UWB received signal and the consequent sparseness of the discrete spatial domain are exploited to select the most significant TOAs and to reduce the amount of information to be sent to a central fusion unit in the DPE approach.
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Conference papers on the topic "Candida intermedia"

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Farrell, S. A., M. Servillat, S. R. Oates, I. Heywood, O. Godet, N. A. Webb, D. Barret, A. Comastri, L. Angelini, and M. Cappi. "Further Observations of the Intermediate Mass Black Hole Candidate ESO 243–49 HLX-1." In X-RAY ASTRONOMY 2009; PRESENT STATUS, MULTI-WAVELENGTH APPROACH AND FUTURE PERSPECTIVES: Proceedings of the International Conference. AIP, 2010. http://dx.doi.org/10.1063/1.3475364.

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FUENTES-CARRERA, I., M. ROSADO, H. FLORES, and J. BORISSOVA. "TRACING THE OPTICAL IMPRINTS OF AN INTERMEDIATE-MASS BLACK HOLE CANDIDATE IN AN INTERACTING GALAXY PAIR." In Proceedings of the MG12 Meeting on General Relativity. WORLD SCIENTIFIC, 2012. http://dx.doi.org/10.1142/9789814374552_0095.

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Shi, Yunbai, Kun Yuan, Xi Zhao, and Yannan Wu. "Study on Comparison Between Inconel 617 and GH3128 as Structural Material Candidates for Intermediate Heat Exchanger." In 2013 21st International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icone21-15948.

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Intermediate heat exchangers (IHXs) are applied to transfer high-temperature heat generated in high-temperature gas-cooled reactor (HTGR) core to the secondary circulation loop. The requirements for IHXs are harsh due to its high operation temperature up to 900–1000°C, as well as long lifetime expectation. Inconel 617, an austenitic alloy based on nickel-chromium, is considered the primary candidate as IHX structural material for application in NGNP program in USA. This paper compares the characteristics of two nickel-base super alloys, namely GH3128 and Inconel 617, in terms of chemical composition, tensile strength and creep behavior. The result shows that GH3128, which was originally developed and deployed for aeronautic blast chamber in China, is also promising for IHXs in nuclear heat application, but much tests have to be done in the future before its successful application in nuclear high-temperature IHXs.
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Chen, Rui, Cheng-Xin Li, and Chang-Jiu Li. "Plasma-Sprayed (Bi2O3)0.705 (Er2O3)0.245 (WO3)0.05 Electrolyte for Intermediate-Temperature Solid Oxide Fuel Cells (IT-SOFCs)." In ITSC2021, edited by F. Azarmi, X. Chen, J. Cizek, C. Cojocaru, B. Jodoin, H. Koivuluoto, Y. C. Lau, et al. ASM International, 2021. http://dx.doi.org/10.31399/asm.cp.itsc2021p0440.

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Abstract Stabilized bismuth oxide with fluorite structure is considered a promising electrolyte material for intermediate temperature solid-oxide fuel cells (SOFCs) due to its high oxygen ion conductivity. The ternary system, Bi2O3-Er2O3-WO3, is of particular interest because it is ionically conductive as well as thermally stable. This study investigates the quality of Bi2O3-Er2O3-WO3 (EWSB) electrolyte produced by plasma spraying. The phase structure and cross-sectional microstructure of plasma-sprayed EWSB were characterized by XRD and SEM. The as-sprayed EWSB was found to have a dense microstructure with well bonded lamellae. XRD analysis showed the formation of EWSB with δ-phase and a trace of β-phase, while the β-phase disappeared after annealing at 750°C for 10h. Electrical property tests revealed that the plasma-sprayed electrolyte also had excellent ionic conductivity (0.26 S cm-1 at 750 °C), making it a strong candidate for use in SOFCs at intermediate temperatures.
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Yue, Nina, Rong Cai, Yun Wang, Suizheng Qiu, and Dalin Zhang. "The Choose of Decay Heat Removal Systems of SFR." In 2018 26th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/icone26-81563.

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A sodium-cooled fast reactor is a significant candidate for future power reactor systems. Decay heat removal is an essential function of reactor safety systems The decay heat removal system should have the capacity to remove the decay heat with natural circulation in any accident. There are three types of decay heat removal systems, namely direct reactor auxiliary cooling system, primary reactor auxiliary cooling system, and intermediate reactor auxiliary cooling system. The one dimensional systems analysis code THACS was applied to conduct transient analyses of a sodium-cooled fast reactor, and the capabilities of three types of decay heat removal systems against a station blackout accident were compared. The results indicate that these three types of decay heat removal systems can remove the residual heat effectively. For large-scale sodium-cooled fast reactor, the capabilities of primary reactor auxiliary cooling system and intermediate reactor auxiliary cooling system were better, because the cold sodium from the penetrating heat exchanger in these two auxiliary cooling systems could directly flow into the core assemblies.
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Zheng, Zhenguo, Oscar Julian Jaramillo, Jhon Patiño, John Fredy Reina, and Carlos Francisco Pacheco. "Successful Acid Stimulation in Limestone - Tobo-Monserrate Formation in Gigante Field - Colombia." In SPE Annual Technical Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/206037-ms.

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Abstract This paper presents the successful stimulation workflow case for a carbonate acidizing pilot project performed in Gigante field in the Matambo block of the Upper Magdalena Valley basin in Colombia. An adecuate diagnostic, laboratory testing, treatment fluid selection, on-site QAQC and placement technique selection was fundamental to obtain a successful design and an optimized application. Gigante field production is mainly coming from Tetuan and Caballos units producing 32-degree API crude oil during several years. Specifically, in Gigante-2 ST well, oil production has declined until its commercial limit. During a candidate wells review, it was identified a previous acid stimulation treatment performed in Tobo-Monserrate formation in Gigante-1 with very poor results in oil production –short production time in natural flow– giving to this zone a low potential as oil producer and it was not considered as a primary target zone. The well was completed in its main target at Tetuan formation leaving Tobo-Monserrate behind an intermediate 7 in casing with no future expectatives to produce. After a reservoir evaluation of Tobo-Monserrate formation done in Gigante-2 ST well, it was selected as a candidate for an intermedia matrix stimulation job to evaluate the real potential of this formation in Matambo block. During this phase, reservoir samples were tested against different acid treatments in the laboratory. A gelled HCL based acid was selected based on their laboratory testing performance to delay acid reaction –improving acid penetration– and having fluid loss control to enhance reservoir coverage. The complete chemical formula was customized to match the oil-treatment compatibility. An organic solvents treatment was added to dissolve organic scale prior to the acidizing. Acid was deployed directly through a TCP string to optimatize the operational time and managing treatment rate according to the pressure behavior. During the acid pumping, a pressure drop is observed and treatment rate was increased to generate rate diversion. Gigante-2 ST well came in production at natural flow reaching 502 BOPD and 105 MSCFD evaluated after 35 days of the stimulation job proving and adding important hydrocarbon reserves from Tobo-Monserrate formation. A post job evaluation using a specialized chemical stimulation simulator shows a significant skin removal. Measured treatment pressure and rate were matched with the simulated parameters resulting in −3.24 of skin value post acid stimulation having a productivity improvement factor of 4.35 and an average wormhole penetration estimated from 60 to 75 in into the reservoir. A correct diagnostic, reservoir understanding, design, laboratory testing, execution and post job evaluation was the right route to obtain a successful stimulation job in operational terms and production results. This paper is intended as a guideline for stimulation jobs in future interventions where the exact reservoir mineralogy is unknown. It shows a step-by-step methodology, a customized acid formula and finally, stimulation results as well as recommendations and learned lessons.
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Roy, Ajit K., Subhra Bandyopadhyay, Silpa Budugur Suresh, and Douglas Wells. "Characterization of Residual Stresses in Structural Materials for Nuclear Applications." In ASME 2005 Pressure Vessels and Piping Conference. ASMEDC, 2005. http://dx.doi.org/10.1115/pvp2005-71490.

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Residual stresses may be generated in target structural material used in accelerator-driven transmutation due to plastic deformation. Nondestructive positron annihilation spectroscopic (PAS) method has been used to estimate residual stresses in candidate structural materials such as martensitic Alloy EP-823 and Alloy HT-9. Different line shape parameters (S, W & T) obtained from the PAS measurements have been related to the degree of cold deformation. The results indicate that the magnitude of S parameter was enhanced at the intermediate level of cold deformation followed by an almost identical S value at the highest level of cold reduction. Conversely, the T parameter was reduced at higher level of cold deformation. The evaluation of the cold-worked specimens by transmission electron microscopy revealed the presence of dislocations, as expected.
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Quayyum, Shahriar, Patrick Graham Pritchard, and Tasnim Hassan. "High Temperature Constitutive Model Development for Alloy 617." In ASME 2014 Symposium on Elevated Temperature Application of Materials for Fossil, Nuclear, and Petrochemical Industries. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/etam2014-1031.

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One of the most challenging tasks in the design code development for Next Generation Nuclear Plant (NGNP) is the design of intermediate heat exchanger (IHX), whose operation temperature may range from 800°C–950°C (1472°F–1742°F). The ASME design code does not have any design provisions for any material at this temperature range. Hence, different candidate materials are under consideration for IHX and one of the leading candidate materials is Ni based Alloy 617. The operating temperature of IHX will be in the creep regime of Alloy 617 and low-cycle creep-fatigue and creep-ratcheting failure mechanisms of Alloy 617 need to be understood. This study is developing a unified constitutive model (UCM) for Alloy 617 based on a broad set of uniaxial and multiaxial creep-fatigue and creep-ratcheting experiments at high temperatures. The experiments were conducted at different temperatures, loading rates and strain ranges prescribing different loading histories. The unified constitutive model was developed based on the Chaboche viscoplastic model framework. Model improvement was performed by including cyclic hardening/softening, dynamic and static recovery, strain rate and strain range dependence, nonproportional loading parameter and multiaxial ratcheting features. The simulated responses of the modified UCM were compared against the broad range of experimental data to demonstrate the robustness of the improved model. The strengths and shortcomings of the model are discussed. Paper published with permission.
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Lee, Gyeong-Geun, Woo-Gon Kim, Yong-Wan Kim, and Ji Yeon Park. "Microstructure Observation of Inconel Alloy 617 Creep-Tested in He Environment at 950°C." In ASME 2010 Pressure Vessels and Piping Division/K-PVP Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/pvp2010-25152.

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The very high temperature gas reactor (VHTR) has been chosen by the Generation IV International Forum as one of the next-generation nuclear reactors. Due to the high operating temperatures of VHTR, Inconel alloy 617 is being considered as a primary candidate material for the intermediate heat exchanger (IHX) of the VHTR. In this study, the microstructures of creep specimens under various creep loads in a He environment were investigated. As the creep time increased, the thickness of Cr-oxide on the outer layer of the specimens clearly increased, and delaminated after a long creep time. Depths of the decarburized zones in the specimens increased slowly with creep time. However, precipitates at grain boundaries near the surface disappeared before the bulk diffusion of Cr in the matrix. It is considered that decarburization caused by minor gas impurities in He caused the reduction in creep rupture time.
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Wright, J. K., L. J. Carroll, T. L. Sham, N. J. Lybeck, and R. N. Wright. "Determination of the Creep-Fatigue Interaction Diagram for Alloy 617." In ASME 2016 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/pvp2016-63704.

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Alloy 617 is the leading candidate material for an intermediate heat exchanger for the very high temperature reactor (VHTR). As part of evaluating the behavior of this material in the expected service conditions, creep–fatigue testing was performed. The cycles to failure decreased compared to fatigue values when a hold time was added at peak tensile strain. At 850°C, increasing the tensile hold duration continued to degrade the creep–fatigue resistance, at least to the investigated strain–controlled hold time of up to 60 minutes at the 0.3% strain range and 240 minutes at the 1.0% strain range. At 950°C, the creep–fatigue cycles to failure are not further reduced with increasing hold duration, indicating saturation occurs at relatively short hold times. The creep and fatigue damage fractions have been calculated and plotted on a creep–fatigue interaction D–diagram. Test data from creep–fatigue tests at 800 and 1000°C on an additional heat of Alloy 617 are also plotted on the D–diagram.
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