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Dissertations / Theses on the topic 'Cannabinoid CB1 receptor'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Smith, Tricia. "Effects of Cannabinoid Receptor Interacting Protein (CRIP1a) on Cannabinoid Receptor (CB1) Function." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1977.

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EFFECTS OF CANNABINOID RECEPTOR INTERACTING PROTEIN (CRIP1a) ON CANNABINOID (CB1) RECEPTOR FUNCTION. By Tricia Hardt Smith, B.S., M.S. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University Virginia Commonwealth University, 2009. Major Director: Dana E. Selley, Ph.D., Department of Pharmacology and Toxicology This dissertation examines modulation of cannabinoid CB1 receptor function by Cannabinoid Receptor Interacting Protein (CRIP1a), a novel protein that binds the C-terminus of CB1 receptors. In Human

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2

Daigle, Tanya L. "Molecular mechanisms of CB1 cannabinoid receptor signaling and internalization /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/10527.

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3

Slaughter, Kimari. "Synthesis and Development of Potential CB1 Receptor Neutral Antagonists." ScholarWorks@UNO, 2012. http://scholarworks.uno.edu/td/1483.

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Cannabis and its derivatives have been used for both medicinal and recreational purposes. The study of this plant led to the discovery of over 60 cannabinoids, found exclusively in cannabis, that contribute to the behavioral effects of cannabis use, the most common is delta-9-tetrahydrocannabinol. Cannabinoid receptors function to increase activity in the mesolimbic dopamine reward system. Dopamine is a neurotransmitter that plays a major role in addition and its regulation plays a crucial role in mental and physical well-being. There is evidence that CB1 receptors are important to the reinfor

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4

Horswill, James G. "Pharmacological characterisation of a novel cannabinoid CB1 receptor allosteric modulator." Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541953.

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5

Grim, Travis. "Synthetic cannabinoids versus delta-9-tetrahydrocannabinol: abuse-related consequences of enhanced efficacy at the cannabinoid 1 receptor." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4039.

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In the past ten years, synthetic cannabinoids (SC) have emerged as drugs of abuse. Unlike D9-tetrahydrocannabinol (THC), many SCs are associated with serious health complications and death. One way in which THC and SCs differ lies with their enhanced potency and efficacy at the CB1 receptor. No current methods exist to measure efficacy at the CB1 receptor in vivo, and the abuse-related properties of SC cannabinoids are not well explored. Here, we utilized CB1 wild type (WT), heterozygous (HET), and knockout (KO) mice. By employing CB1 ligands which differ in efficacy we have developed a method

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6

Wing, Victoria Caroline. "The role of the cannabinoid CB1 receptor subtype in nicotine dependence." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500924.

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Tobacco smoking, considered an addiction to nicotine, is a worldwide health problem but limited effective pharmacotherapies are available. Nicotine acts on nicotinic acetylcholine receptors in the brain thus interacting with a range of neurotransmitter systems of which the mesocorticolimbic dopamine system is considered crucial for drug dependence. The endocannabinoid system has also been implicated in nicotine dependence and the cannabinoid CB1 receptor antagonist rimonabant has shown efficacy as a smoking cessation aid. This thesis aimed to further examine the role of CBl receptors in the mo

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Marcu, Jahan Phillip. "Novel Insights into CB1 Receptor Signaling and the Anabolic Role of Cannabinoid Receptors in Bone." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/233543.

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Cell Biology<br>Ph.D.<br>Activation of the CB1 receptor is modulated by aspartate residue D2.63176 in transmembrane helix (TMH) II. Interestingly, D2.63 does not affect the affinity for ligand binding at the CB1 receptor. Studies in class A GPCRs have suggested an ionic interaction between residues of TMHII and VII. In this report, modeling studies identified residue K373, in the extracellular (EC)-3 loop, in charged interactions with D2.63. We investigated this possibility by performing reciprocal mutations and biochemical studies. D2.63176A, K373A, D2.63176A-K373A, and the reciprocal mutant

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8

Feliszek, Monika [Verfasser]. "Age-dependent cannabinoid CB1 receptor plasticity and search for histamine H4 receptors in the brain / Monika Feliszek." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1119888875/34.

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9

Jacob, Wolfgang. "Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-72307.

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10

Marsicano, Giovanni. "Physiological role of the cannabinoid receptor 1 (CB1) in the murine central nervous system." Thesis, Open University, 2001. http://oro.open.ac.uk/58198/.

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The cannabinoid system is involved in many functions of mammalian brain, such as learning and memory, pain perception and 'locomotion. The "brain type" cannabinoid receptor CB 1 is one of the key elements of the cannabinoid system. In this Thesis, some aspects of the neurobiology of mouse CB 1 are described. CB 1 mRNA distribution was analysed by single and double in situ hybridization (ISH), revealing the expression of the receptor in specific neuronal subpopulations. This expression pattern suggests many putative functional cross-talks between the cannabinoid system and other signalling mole

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Marsicano, Giovanni. "Physiological role of the cannabinoid receptor 1 (CB1) in the murine central nervous system." n.p, 2000. http://ethos.bl.uk/.

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12

Galera, López Lorena 1993. "Signalling mechanisms involved in memory function : focus on the effects of Δ9-tetrahydrocannabinol". Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/672693.

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Memory is a physiological brain function crucial for adaptive behaviour of individuals. Memory alterations are described as impairments in the processes by which memory is perceived, encoded, consolidated, retrieved, or used. there are countless situations that can lead to memory alterations. In this thesis we used specific murine mouse models to study the cellular and molecular mechanisms involved in learning and memory performance in specific situations where memory is compromised. Specifically, we described that repeated non-amnesic low doses of Δ9-tetrahydrocannabinol (THC) affect memory p

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13

Altomonte, Stefano. "Cannabinoid receptor subtype-1 (CB1) ligands : synthesis and brain PET imaging with 11C and 18F radiotracers." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=214832.

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14

Bajzer, Matej. "The Role of the Cannabinoid Receptor Type 1 in Energy Balance, Glucose Metabolism, and Thermogenesis." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367944745.

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15

Fournet, Steven P. "High Resolution X-ray Diffraction Analysis of CB1 Receptor Antagonists as a Means to Explore Binding Affinity." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/td/1737.

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Abstract Charge density studies have been conducted on ten CB1 cannabinoid receptor antagonists via high resolution x-ray crystallography. Bond critical point values and various other properties derived from these studies including the electrostatic potential were analyzed in correlation to the affinity of each compound with the CB1 receptor. Correlation/anti-correlation was found between several properties and Ki. The data was also interpreted by principal component analysis with three principal components accounting for 85% of the data variation. Data mining was limit due to the low sample c

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Vrechi, Talita Aparecida de Moraes. "O potencial terapêutico de compostos canabinoides em um modelo in vitro de morte neuronal." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-11082016-090204/.

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A neurodegeneração é o resultado da destruição progressiva e irreversível dos neurônios no sistema nervoso central, apresentando causas desconhecidas e mecanismos patológicos não totalmente elucidados. Fatores como a idade, o aumento da formação de radicais livres e/ou estresse oxidativo, defeito no metabolismo energético, a inflamação e acúmulo de elementos neurotóxicos e de proteínas malformadas no lúmen do retículo endoplasmático (RE) contribuem para o desenvolvimento dos processos neurodegenerativos. O sistema canabinoide tem sido proposto como neuroprotetor em diversos modelos de neurodeg

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Zehr, Bradley Preston. "Cannabinoid receptor 1 (CB1) agonist arachidonyl-2'-chloroethylamide (ACEA) induces Egr1 in murine 3T3-L1 and human adipocytes." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12255.

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Thesis (M.A.)--Boston University<br>Obesity and type 2 diabetes mellitus are parallel global pandemics fueled by worldwide trends toward longer lifespan, Western high-fat diet, and sedentary lifestyle. Lipotoxicity – lipid overflow from adipose tissue to liver, muscle, and pancreas resulting from chronically elevated plasma free fatty acid levels – is now known to be the underlying cause of insulin resistance and T2DM. Control of lipolysis in adipose tissue is central to the regulation of plasma free fatty acid. Adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme in adipose

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18

Häring, Martin [Verfasser]. "Cannabinoid CB1 receptor in the regulation of sociability, stress coping, and its interaction with the serotonergic system / Martin Häring." Mainz : Universitätsbibliothek Mainz, 2012. http://d-nb.info/1026397057/34.

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19

Schlosburg, Joel. "Differential roles of the two major endocannabinoid hydrolyzing enzymes in cannabinoid receptor tolerance and somatic withdrawal." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2107.

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While there is currently active debate over possible therapeutic applications of marijuana and cannabis-based compounds, consistently their primary drawbacks have been the psychoactive properties, dependence, and abuse potential. Prolonged administration of ∆9-tetrahydrocannabinol (THC), the primary psychoactive constituent in marijuana, demonstrates both tolerance and physical withdrawal in both preclinical and clinical studies. Repeated THC administration also produces CB1 receptor adaptations in the form of reduced activation of receptors, along with a downregulation of membrane surface rec

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La, Porta Carmen 1985. "Involvement of the endocannabinoid system in osteoarthritis pain." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/398384.

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Chronic pain is a major clinical problem producing huge economic and social burdens. Currently, chronic pain treatment has limited efficacy and significant side effects. One of the reasons of this unmet clinical need is the insufficient knowledge of the exact mechanisms involved in the generation and maintenance of chronic pain and pain-related comorbidities, such as affective and cognitive disorders that can negatively affect the life quality of patients. It is an important challenge to treat not only the nociceptive symptoms, but also the comorbidities accompanying chronic pain. In the prese

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Bouwer, Adoree. "An in Vitro investigation of the effects of Rimonabant (a cannabinoid CB1 receptor antagonist) on cell adhesion and inflammatory associated cytokine production." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/24508.

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There is good pharmacological evidence that cannabinoids caused cellular changes by interacting with specific cannabinoid receptors (CBR) (Klein et al., 2000). To date, two CBRs have been identified in the human body, designated Cannabinoid Receptor 1 (CB1) and Cannabinoid Receptor 2 (CB2) (Begg et al., 2005). Endogenously occurring compounds with action at the CBRs also exist and they are called endocannabinoids. One of the four known endocannabinoids is anandamide (AEA). The endocannabinoid system, present in the human body, plays a significant role in altering the physiology of the immune s

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SOFFIA, SILVIA. "Agonists of the Cannabinoid Receptor Type 1 (CB1) Promote Rat Cerebellar Neural Progenitor Cell Proliferation Through Activation of ERK and Akt Pathways." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3421532.

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Endocannabinoids represent a novel class of intercellular messengers, the function of which includes retrograde signaling in the brain and mediation or modulation of several types of synaptic plasticity. Endocannabinoid signaling not only regulates the proliferation, migration, specification, survival, and phenotypic differentiation of neural progenitors during central nervous development (Harkany,T. et al., 2008) but has been shown to control proliferation and differentiation of neural stem/progenitor cells in the hippocampal subgranular zone and in the subventricular zone of the adult mammal

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23

Soria, Rodríguez Guadalupe. "Sistemas cannabinoide y purinérgico: posibles sustratos neurobiológicos de la drogadicción." Doctoral thesis, Universitat Pompeu Fabra, 2006. http://hdl.handle.net/10803/7101.

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La adicción es un trastorno crónico de la conducta caracterizado por la búsqueda y el consumo compulsivos de la droga, la pérdida de control para limitar dicho consumo, a aparición de un estado emocional negativo cuando el acceso a la droga está impedido y la recaída en el proceso incluso tras largos períodos de abstinencia. El sistema dopaminérgico mesolímbico cortical ha sido propuesto como la principal base neurobiológica de la adicción, sin embargo existen otros sistemas de neurotransmision que participan en la consolidación del proceso adictivo.<br/>El sistema endocannabinoide, a traves d

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Busquets, Garcia Arnau 1985. "Targeting the endocannabinoid system for therapeutic purposes." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/119617.

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The endocannabinoid system is an endogenous neuromodulatory system that regulates a plethora of physiological functions, including the modulation of memory, anxiety, pain, synaptic plasticity and neuronal excitability, among others. The activation of this system through exogenous or endogenous cannabinoid agonists has been proposed as a therapeutic strategy in different pathological states, although an important caveat to their use is the possible central adverse effects, such as memory impairment, anxiety and tolerance. The activity of the endocannabinoid system has been recently found involv

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25

Ghosh, Sudeshna. "Targeting the Endocannabinoid System to Reduce Inflammatory Pain." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/313.

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The endogenous cannabinoids (endocannabinoids) anandamide (AEA) and 2-arachidonylglycerol (2-AG) exert their effects predominantly through cannabinoid CB1 and CB2 receptors, but these actions are short-lived because of rapid hydrolysis by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. Selective inhibition of either enzyme elevates CNS levels of the appropriate endocannabinoid and produces analgesic effects with fewer psychomimetic side effects than Δ9-tetrahydrocannabinol (THC), the primary active constituent of marijuana. While cannabinoid receptor agonist

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Sherwood, Alexander M. "Design, Synthesis and Biological Evaluation of Novel Compounds with CNS-Activity Targeting Cannabinoid and Biogenic Amine Receptors." ScholarWorks@UNO, 2014. http://scholarworks.uno.edu/td/1831.

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This work seeks to contribute to the discipline of neuropharmacology by way of structure activity relationship from the standpoint of an organic chemist. More specifically, we sought to develop robust synthetic methodology able to efficiently produce an array of compounds for the purpose of systematic evaluation of their interaction with specific sights within the central nervous system (CNS) in order to better understand the mind and to develop drugs that may have beneficial effects on neurological function. The focus of these studies has been toward the development of novel molecules, using

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Kerr, Jamie. "Allosteric modulation of the CB1 receptor." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=196261.

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Bioactive compounds from Cannabis sativa have been used for millennia to alleviate the symptoms of a range of diseases. The physiological basis of effects such as analgesia, stimulation of hunger and reduction of inflammation was established in the late 20th century with the discovery of cannabinoid receptors but efforts to synthesise safe and potent drugs targeting these proteins have so far failed. The major barrier to research in this area is the instability of the receptors outside of biological settings, rendering elucidation of the binding sites by traditional means difficult. Certain sm

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Aso, Pérez Ester. "Participación del sistema cannabinoide endógeno en el control de las respuestas relacionadas con trastornos afectivos." Doctoral thesis, Universitat Pompeu Fabra, 2008. http://hdl.handle.net/10803/7132.

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Los trastornos emocionales de tipo depresivo y la ansiedad son las formas más prevalentes de enfermedad mental y suponen un serio problema de salud en la sociedad occidental. Recientemente, se ha postulado que el sistema endocannabinoide pueda ser un importante sustrato en el desarrollo de estos trastornos dada su participación en el control de las emociones. Nuestros resultados demuestran que los animales carentes del receptor cannabinoide CB1 manifiestan un fenotipo de tipo depresivo asociado a una deficiencia del factor neurotrófico BDNF en el hipocampo, que podría estar causada por los ele

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RUGGIERO, Emanuela. "Discovery of new CB2 cannabinoid receptor full agonists." Doctoral thesis, Università degli studi di Ferrara, 2014. http://hdl.handle.net/11392/2389407.

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Xiang, Guoqing. "Signaling Through Homomeric and Heteromeric Cannabinoid CB1 receptors." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5683.

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Cannabis (Marijuana) has multiple effects on the human body, such as analgesia, euphoria and memory impairment. Delta-9 tetrahydrocannabinol (D9-THC), the active ingredient in cannabis, binds to cannabinoid receptors, seven-transmembrane G protein-coupled receptors (GPCRs) that mediate a variety of physiological functions. GPCRs were believed to function only in homomeric forms, however, recent findings show that different GPCRs can also form heteromeric complexes that may expand their signaling properties. In this study, we focused on Cannabinoid CB1 receptor (CB1R) heteromers with the mu-opi

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Cavuoto, Paul. "Effect of cannabinoid CB1 receptors on skeletal muscle oxidative pathways /." Title page and abstract only, 2005. http://web4.library.adelaide.edu.au/theses/09SB/09sbc383.pdf.

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Green, Brannon M. "CB1 receptor antagonist AM-251 effect on spatial memory in male mice /." [Chico, Calif. : California State University, Chico], 2009. http://hdl.handle.net/10211.4/83.

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Metna-Laurent, Mathilde. "Cell Type-Specific Control of Memory Functions by CB1 Cannabinoid Receptors." Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR21928/document.

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Le système endocannabinoïde est un important modulateur des fonctions physiologiques. Dans le cerveau, son contrôle s’exerce essentiellement par les récepteurs cannabinoïdes de type 1 (CB1). Les récepteurs CB1 sont abondamment exprimés sur les neurones excitateurs glutamatergiques et les interneurones inhibiteurs GABAergiques et leur stimulation inhibe la libération du glutamate et du GABA. Récemment, l’activité des récepteurs CB1 sur les astrocytes a été proposée comme facilitant la transmission excitatrice. Par ce contrôle général de la neurotransmission, l’activité des récepteurs CB1 induit

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Collier, Lauren Michele. "Relationship Between CB1 and S1P Receptors in the Central Nervous System." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/733.

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There is significant sequence homology and anatomical co-distribution between cannabinoid (CB1) and sphingosine-1-phosphate (S1P) receptors in the CNS, but potential functional relationships between these lysolipid receptors have not been examined. Therefore, to investigate possible relationships between these two systems at the level of G-protein activation, agonist-stimulated [35S]GTPγS binding and autoradiography were conducted. Autoradiographic studies were first performed to localize receptor-mediated G-protein activation in mouse brain. Coronal brain slices were processed for stimulation

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Bernardes, Terzian Ana Luisa. "Behavioral phenotypes of mice lacking cannabinoid CB1 receptors in different neuronal subpopulations." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-170356.

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Abnormalities in social behavior are found in almost all psychiatric disorders, such as anxiety, depression, autism and schizophrenia. Thus, comprehension of the neurobiological basis of social interaction is important to better understand numerous pathologies and improve treatments. Several evidences suggest that an alteration of cannabinoid CB1 receptor function could be involved in the pathophysiology of such disorders. However, the role of CB1 receptor is still unclear and its localization on different neuronal subpopulations may produce distinct outcomes. To dissect the role of CB1 recept

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Ibrahim, Mohab Mohamed. "Pain-modulating effects of peripheral (CB2) cannabinoid receptors." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280554.

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Cannabinoid receptor agonists diminish responses to painful stimuli. Extensive evidence implicates the CB1, receptor in the production of antinociception, inflammatory hyperalgesia, and peripheral nerve injury-induced sensory hypersensitivity. In previous work included in my masters thesis, our laboratory has demonstrated the capacity of CB2 receptors located outside the central nervous system (CNS) to inhibit acute nociception and inflammatory hyperalgesia. In this thesis, I use AM1241, a CB2 receptor-selective agonist to test the hypothesis that CB2 receptor activation reverses the tactile a

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Elmes, Steven. "Cannabinoid CBâ‚‚ receptor activation inhibits acute and inflammatory pain." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420331.

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Netherland, Courtney Denise. "Role of Type 2 Cannabinoid Receptor (CB2) in Atherosclerosis." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1392.

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Atherosclerosis is a macrophage-dominated nonresolving inflammatory disease of the arterial wall. Macrophage processes, including apoptosis, influence lesion development in atherosclerosis. Cannabinoids, compounds structurally related to Δ9-tetrahydrocannabinol (THC), the active ingredient in marijuana, exert their effects through cannabinoid receptors, CB1 and CB2. Cannabinoid treatment, THC or Win55,212-2, reduces atherosclerosis in ApoE-null mice by a mechanism thought to involve CB2. However, the exact role of CB2 in atherosclerosis remains unclear. We found that CB2-null macrophages are r

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Robin, Laurie. "Roles of astroglial cannabinoid type 1 receptors (CB1) in memory and synaptic plasticity." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0283/document.

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Le système endocannabinoïde est un important modulateur des fonctions physiologiques. Il est composé des récepteurs aux cannabinoïdes, de ses ligands lipides endogènes (les endocannabinoïdes) et de la machinerie enzymatique pour leur synthèse et leur dégradation. Les récepteurs aux cannabinoïdes de type 1 (CB1) sont exprimés dans différents types cellulaires dans le cerveau et sont connus pour être impliqués dans les processus mnésiques. Les endocannabinoïdes sont mobilisés dépendamment de l’activité notamment dans les régions cérébrales impliquées dans la mémoire telle que l’hippocampe. Dans

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Holt, Christopher James. "Design, synthesis and evaluation of fluorescent CB2 cannabinoid receptor ligands." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/10712/.

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Cannabis has been used as a medicinal and natural product for thousands of years. Whether it has been used to make rope or paper, or been used to treat pain or depression, cannabis has always had a place in human civilisation. With the isolation of the psychoactive compounds responsible for cannabis’ effects, the discovery of two human cannabinoid receptors and an expanding knowledge of the therapeutic uses of cannabis, interest in the development of novel cannabinoids grew. The CB2 cannabinoid receptor has gained particular attention, as the often unwanted central and psychoactive effects of

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Òdena, Garcia Gemma. "Paper del receptor de cannabinoides 1 (CB1) a la Cirrosi experimental. Efecte del bloqueig de CB1 sobre les complicacions de la cirrosi." Doctoral thesis, Universitat Autònoma de Barcelona, 2011. http://hdl.handle.net/10803/83997.

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La cirrosi és una malaltia crònica, difusa i considerada irreversible, caracteritzada per l’alteració de l’arquitectura vascular hepàtica provocada pel reemplaçament del teixit parenquimàtic per teixit fibròtic, així com per l’aparició de nòduls de regeneració. Aquesta destrucció del teixit hepàtic i la seva substitució per teixit fibrós provoca un augment marcat de la resistència al flux de la vena porta, així com una greu alteració de la funció hepàtica. A més d’un risc augmentat d’aparició de càncer hepàtic, les complicacions més freqüents i potencialment mortals de la cirrosi, associades

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Dodd, Garron. "Appetite and functional brain responses to cannabinoids." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/appetite-and-functional-brain-responses-to-cannabinoids(b2b4f7e8-d711-421e-867e-fcf017bfccf0).html.

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The obesity epidemic is a major health threat affecting one in four people in the affluent western world, where high-energy foods are easily available and there is little need for exercise. To identify novel therapeutic targets for the treatment of obesity, one important step is to further define the complex circuitry in the brainwhich is ultimately responsible for our appetite and body weight regulation. Although complex, appetite can be thought of as having two distinct, though none mutually exclusive, aspects: the need to eat (homeostatic) and the desire to eat(hedonistic).The need to eat,

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Ramírez, López Ángela 1992. "Role of CB2 cannabinoid receptor in nociception and food intake control." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/672620.

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The endocannabinoid system is a natural modulatory system that participates in multiple physiological processes, including nociceptive, emotional and rewarding responses. These central responses are mainly mediated by cannabinoid receptor 1 (CB1R)-dependent mechanisms, although the side effects associated to these central responses limit the therapeutic use of CB1R agonists. Recent research on the cannabinoid receptor 2 (CB2R) provides an alternative approach to avoid the central side effects associated with CB1R stimulation. The purpose of this Thesis was to investigate the involvement of CB2

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Raborn, Erinn Shenee. "Cannabinoid Modulation of Chemotaxis of Macrophages and Macrophage-like Cells." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/1333.

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Fulmer, Makenzie. "Role of Cannabinoid Receptor Type 2 (CB2) in Late Stage Atherosclerosis." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3328.

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Atherosclerosis is a chronic inflammatory disorder of medium and large vessels. Immune signaling and dyslipidemia are two of several processes which influence lesion development in atherosclerosis. Cannabinoids, such as those found in marijuana, exert their effects through two cannabinoid receptors, CB1 and CB2. Recent studies using CB2 knockout mice and CB2-selective ligands have shed light on a protective role of CB2 in early stages of atherosclerosis. However, the role of CB2 in advanced stages of atherosclerosis remains unclear. To determine if CB2 plays a role in advanced atherosclerotic

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Hepburn, Claire Y. "Studies investigating the mechanisms of the cardioprotective effects of cannabidiol." Thesis, Robert Gordon University, 2014. http://hdl.handle.net/10059/1002.

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The phytocannabinoid cannabidiol (CBD) has a complex pharmacology which is thought to include, but is not limited to, an ability to act as an inverse agonist at the CB1 and CB2 receptors and an antagonist of GPR55. Moreover, is has been shown to reduce infarct size and ameliorate reductions in left ventricular function in vivo. These improvements in the pathogenesis of experimental MI are accompanied by a reduction in inflammatory cell migration to the area at risk. More recently it has been shown that CBD is anti-arrhythmic in acute experimental MI. Thus, it was suggested that the cardioprote

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Falenski, Katherine Winslow. "Functional Redistribution of Hippocampal Cannabinoid Cb1 Receptors in the Rat Pilocarpine Model of Acquired Epilepsy." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1280.

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Cannabinoids, such as the marijuana derivative Δ9-THC, are known to have CBl receptor-mediated anticonvulsant effects in several animal models of seizures and epilepsy, including the rat pilocarpine model of acquired epilepsy. However, the distribution of CBl receptor expression and function in brains of epileptic rats has not been characterized. Therefore, this dissertation was initiated to evaluate the effect of epileptogenesis on the distribution and function of the endogenous CBI receptor system in the rat pilocarpine model, a well-established model of acquired temporal lobe epilepsy. Usin

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Kossatz, de Mello Elk 1977. "Neuroprotective mechanisms of CB2 cannabinoid receptors and PPAR-α in hypoxia/ischemia-induced brain damage". Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/664430.

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In this thesis, we have developed a hypoxia-ischemia (HI) model in adult mice to study the neuroprotective mechanisms of CB2 cannabinoid receptors (CB2R), and the potential therapeutic effects of the new PPAR-α agonist, octadecylpropyl sulfamide (SUL). First, we determined the behavioural and cognitive alterations induced by HI in CB2R knockout (KO) mice and wild-type (WT) littermates, as well as, the cellular and molecular alterations associated with brain injury. Second, we evaluated the effects of SUL on the behavioural and cognitive alterations induced by HI in C57BL/6J adult mice, and stu

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Abdelrahman, Mostafa Hamed. "Design, synthesis and SAR of novel allosteric modulators of the Cannabinoid CBI receptor." Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=159203.

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We report on the design, synthesis, and structure activity relationship studies of novel Org 27569 analogues as potential allosteric modulators of the CB1 receptors. We also investigated by computer modelling the possible location of the allosteric site on CB1 and the binding confirmation of the allosteric ligands. Docking of the synthesised molecules is also performed and the results are compared to the results of the biological bioassays. The synthesis of non-fused indole analogues of Org 27569 is described. These analogues were systematically varied to study the importance of key functional

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Yates, Andrew Stephen. "Fluorescent cannabinoids : strategies towards the synthesis of fluorescently labelled CB2 receptor ligands." Thesis, University of Nottingham, 2005. http://eprints.nottingham.ac.uk/10107/.

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An increased understanding of the peripheral cannabinoid receptor (CB2) is required due to the CB2 receptor's emerging involvement in a number of disease states. New fluorescent technologies are capable of generating information about the CB2 receptor systems that has been unachievable using existing pharmacological methods i.e. radioisotope techniques. Our work, to develop fluorescently labelled CB2 receptor ligands, will provide cannabis researchers a unique pharmacological tool to use in conjunction with these emerging fluorescent technologies. This will aid the understanding of cellular ac

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