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Journal articles on the topic 'Canned grapefruit juice'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 January 2023

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1

Nagy, Steven, Hyoung Lee, Russell L. Rouseff, and James C. C. Lin. "Nonenzymic browning of commercially canned and bottled grapefruit juice." Journal of Agricultural and Food Chemistry 38, no. 2 (February 1990): 343–46. http://dx.doi.org/10.1021/jf00092a001.

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2

Pino, J., and Ana M. Cabrera. "Quality of canned grapefruit juice produced in Cuba during four seasons." Food / Nahrung 32, no. 9 (1988): 875–79. http://dx.doi.org/10.1002/food.19880320919.

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3

MANNHEIM, H. G., A. BAKAL, and D. REZNIK. "Shelf life of canned grapefruit juice - methods for evaluation and factors affecting it." International Journal of Food Science & Technology 3, no. 2 (June 28, 2007): 115–22. http://dx.doi.org/10.1111/j.1365-2621.1968.tb01446.x.

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4

SAGUY, I., C. H. MANNHEIM, and N. PASSY. "The role of sulphur dioxide and nitrate on detinning of canned grapefruit juice." International Journal of Food Science & Technology 8, no. 2 (June 28, 2007): 147–55. http://dx.doi.org/10.1111/j.1365-2621.1973.tb01700.x.

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5

Nagy, Steven, and Seifollah Nikdel. "Tin, iron, and aluminum contents of commercially canned single-strength grapefruit juice stored at varying temperatures." Journal of Agricultural and Food Chemistry 34, no. 4 (July 1986): 588–93. http://dx.doi.org/10.1021/jf00070a002.

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6

ROUSEFF, R. L., and S. V. TING. "Effects of pH, Storage Time and Temperature on the Tin Content of Single Strength Canned Grapefruit Juice." Journal of Food Science 50, no. 2 (August 25, 2006): 333–35. http://dx.doi.org/10.1111/j.1365-2621.1985.tb13394.x.

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7

PINO, JORGE A., RAUL TORRICELLA, and LUIS CHANG. "RELATIONSHIP BETWEEN SENSORY AND ANALYTICAL DETERMINATIONS OF CANNED SINGLE-STRENGTH GRAPEFRUIT JUICE AS DETERMINED BY PRINCIPAL COMPONENT ANALYSIS." Journal of Food Quality 17, no. 1 (March 1994): 1–8. http://dx.doi.org/10.1111/j.1745-4557.1994.tb00126.x.

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8

Korolev, Aleksei, Ekaterina Kirpichenkova, Elena Nikitenko, Elena Denisova, and Elena Fanda. "Lycopene Quantity and Sources in the Diet of Healthy Young People." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 117. http://dx.doi.org/10.1093/cdn/nzaa041_021.

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Abstract Objectives Lycopene is a major dietary non-vitamin carotenoid, which has a high number of conjugated dienes, and known as a powerful antioxidant and radical scavenger. The present study was designed to assess the level of lycopene intake and to describe which food sources contribute the most to intake. Methods Lycopene's level and its main food sources were assessed using the 24-hour reсall method. Periodicity of intake food sources were assessed using a specialized Food Frequency Questionnaire applying the carotenoids database from the USDA. A survey was conducted among 122 students in age group 20 to 28 years (21.86 ± 1.12) and included 89 females and 33 males. Results Only 43.4% respondents have achieved the recommended level of lycopene (12.64 ± 8.57 mg/day). In this group the following sources of lycopene were presented: red raw tomatoes (47.2%), fast food products – pizza, lasagna, pasta (18.9%), ketchup (15.1%), watermelon (11.3%), tomato juice (5.6%), pink and red grapefruits (1.9%). For 14.7% students the intake of lycopene in the diet was more than half of the recommended level. The main sources of lycopene in this group were red raw tomatoes (61.1%), pizza, sandwiches (33.3%), and ketchup (5.6%). For 15.6% participants the dietary intake of lycopene was less than half of the recommended level. In this group, the major sources of lycopene were the following: ketchup (21.3%), soup and sandwiches (21.1% each), red raw tomatoes (15.8%), canned fish in tomato sauce (10.5%) and tomato juice (5.2%). A quarter of respondents had no sources of lycopene in their diet. An assessment of the results of survey of 122 students revealed that 91 respondents included red raw tomatoes in weekly diet (9.0% – 6–7 times a week, 47.6% – 3–5 times a week, 18.0% – 1–2 times a week). The weekly diet of more than a third of respondents contained tomato-based sources of lycopene: pizza (47.5%), ketchup (46.7%), cheeseburger (34.4%) and hamburger (17.2%). Thus, the significant number of study participants did not include tomato juice (55.7%), red tomatoes (49.1%), persimmon (45.9%), pink or red grapefruit (41.0%). Conclusions The recommended quantity of lycopene intake was achieved by including raw red tomatoes and tomato-containing products in the diet. Additional sources of lycopene (watermelon, red and pink grapefruits, persimmon) in the diet of most students were absent. Funding Sources No funding.

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9

Naz, Sania, Anila Sajjad, Joham Ali, and MUHAMMAD ZIA. "Antioxidative, phytochemical and antimicrobial analysis of juices of eight citrus cultivars grown in Pakistan." Natural Resources for Human Health 2, no. 3 (January 28, 2022): 300–305. http://dx.doi.org/10.53365/nrfhh/145221.

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Comparative nutritional analysis of citrus varieties cultivated in Pakistan has not been reported. Citrus is consumed all over the world due to its taste and also has pharmacological components. The present investigation evaluated the antioxidant, reducing power, total flavonoids and phenolics, DPPH free radical scavenging, protein kinase inhibition, and the antimicrobial activities of eight Pakistani citrus varieties. Grapefruit showed maximum total antioxidant potential (77 µg AAE/100 mg), followed by Kinnow and Shakri. Khatai showed maximum reducing power potential (69.6 µg AAE/100 mg) while Shakri and Grapefruit trailed it. All the varieties showed significant DPPH free radical scavenging activity. Maximum total phenolics in citrus juice were found in Shakri and Kinnow; 26.2 and 25.9 µg GAE/100mg, respectively. Variation in total flavonoids content was observed as Kinnow>Grapefruit>Shakri>Khatai. All the citrus juices showed mild to moderate antibacterial activity, while Mosambi and Malta contained potent antifungal components. HPLC analysis of citrus juices revealed that catechin was present in all citrus genotypes except Kinnow. The study concludes that citrus juices contain strong antioxidative potential, bear protein kinase inhibitors and can be used as cancer chemoprevention and supportive nutrition.

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10

Stanly, Christopher, Mariaevelina Alfieri, Alfredo Ambrosone, Antonietta Leone, Immacolata Fiume, and Gabriella Pocsfalvi. "Grapefruit-Derived Micro and Nanovesicles Show Distinct Metabolome Profiles and Anticancer Activities in the A375 Human Melanoma Cell Line." Cells 9, no. 12 (December 21, 2020): 2722. http://dx.doi.org/10.3390/cells9122722.

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Fruit juice is one of the most easily accessible resources for the isolation of plant-derived vesicles. Here we found that micro- and nano-sized vesicles (MVs and NVs) from four Citrus species, C. sinensis, C. limon, C. paradisi and C. aurantium, specifically inhibit the proliferation of lung, skin and breast cancer cells, with no substantial effect on the growth of non-cancer cells. Cellular and molecular analyses demonstrate that grapefruit-derived vesicles cause cell cycle arrest at G2/M checkpoint associated with a reduced cyclins B1 and B2 expression levels and the upregulation of cell cycle inhibitor p21. Further data suggest the inhibition of Akt and ERK signalling, reduced intercellular cell adhesion molecule-1 and cathepsins expressions, and the presence of cleaved PARP-1, all associated with the observed changes at the cellular level. Gas chromatography-mass spectrometry-based metabolomics reveals distinct metabolite profiles for the juice and vesicle fractions. NVs exhibit a high relative amount of amino acids and organic acids whereas MVs and fruit juice are characterized by a high percentage of sugars and sugar derivatives. Grapefruit-derived NVs are in particular rich in alpha–hydroxy acids and leucine/isoleucine, myo-inositol and doconexent, while quininic acid was detected in MVs. Our findings reveal the metabolite signatures of grapefruit-derived vesicles and substantiate their potential use in new anticancer strategies.

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11

Kim, E. H., S. E. Hankinson, A. H. Eliassen, and W. C. Willett. "A prospective study of grapefruit and grapefruit juice intake and breast cancer risk." British Journal of Cancer 98, no. 1 (November 20, 2007): 240–41. http://dx.doi.org/10.1038/sj.bjc.6604105.

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12

Ito, Hideyuki, Marie-Paule Gonthier, Claudine Manach, Christine Morand, Louise Mennen, Christian Rémésy, and Augustin Scalbert. "Polyphenol levels in human urine after intake of six different polyphenol-rich beverages." British Journal of Nutrition 94, no. 4 (October 2005): 500–509. http://dx.doi.org/10.1079/bjn20051522.

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Dietary polyphenols are suggested to participate in the prevention of CVD and cancer. It is essential for epidemiological studies to be able to compare intake of the main dietary polyphenols in populations. The present paper describes a fast method suitable for the analysis of polyphenols in urine, selected as potential biomarkers of intake. This method is applied to the estimation of polyphenol recovery after ingestion of six different polyphenol-rich beverages. Fifteen polyphenols including mammalian lignans (enterodiol and enterolactone), several phenolic acids (chlorogenic, caffeic,m-coumaric, gallic, and 4-O-methylgallic acids), phloretin and various flavonoids (catechin, epicatechin, quercetin, isorhamnetin, kaempferol, hesperetin, and naringenin) were simultaneously quantified in human urine by HPLC coupled with electrospray ionisation mass-MS (HPLC-electrospray-tandem mass spectrometry) with a run time of 6 min per sample. The method has been validated with regard to linearity, precision, and accuracy in intra- and inter-day assays. It was applied to urine samples collected from nine volunteers in the 24 h following consumption of either green tea, a grape-skin extract, cocoa beverage, coffee, grapefruit juice or orange juice. Levels of urinary excretion suggest that chlorogenic acid, gallic acid, epicatechin, naringenin or hesperetin could be used as specific biomarkers to evaluate the consumption of coffee, wine, tea or cocoa, and citrus juices respectively.

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13

Kharasch, Evan D., Dale Whittington, and Christine Hoffer. "Influence of Hepatic and Intestinal Cytochrome P4503A Activity on the Acute Disposition and Effects of Oral Transmucosal Fentanyl Citrate." Anesthesiology 101, no. 3 (September 1, 2004): 729–37. http://dx.doi.org/10.1097/00000542-200409000-00022.

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Background Oral transmucosal fentanyl citrate (OTF) was developed to provide rapid analgesia and is specifically approved for treating breakthrough cancer pain. Fentanyl in OTF is absorbed across the oral mucosa, but a considerable portion is swallowed and absorbed enterally. Fentanyl metabolism is catalyzed by cytochrome P4503A4 (CYP3A). The role of intestinal or hepatic first-pass metabolism and CYP3A activity in OTF disposition is unknown. This investigation examined the influence of hepatic and intestinal CYP3A activity on the disposition and clinical effects of OTF. Methods Healthy volunteers (n = 12) were studied in an Institutional Review Board-approved, randomized, balanced, four-way crossover. They received OTF (10 microg/kg) after hepatic/intestinal CYP3A induction by rifampin, hepatic/intestinal CYP3A inhibition by troleandomycin, selective intestinal CYP3A inhibition by grapefruit juice, or nothing (control). Plasma fentanyl and norfentanyl concentrations were determined by mass spectrometry. Fentanyl effects were measured by dark-adapted pupil diameter and subjective self-assessments using visual analog scales. Results : Peak plasma fentanyl concentrations, time to peak, and maximum pupil diameter change from baseline were unchanged after rifampin, troleandomycin, and grapefruit juice. Fentanyl elimination, however, was significantly affected by CYP3A alterations. After control, rifampin, troleandomycin and grapefruit juice, respectively, area under the curve of plasma fentanyl versus time was 5.9 +/- 3.7, 2.2 +/- 0.8,* 10.4 +/- 8.9,* and 5.8 +/- 3.3 h x ng/ml; norfentanyl/fentanyl plasma area under the curve ratios were 0.92 +/- 0.63, 3.2 +/- 1.8,* 0.08 +/- 0.14,* and 0.67 +/- 0.33 (*P < 0.05 versus control). Discussion Peak fentanyl concentrations and clinical effects after OTF were minimally affected by altering both intestinal and hepatic CYP3A activity, whereas fentanyl metabolism, elimination, and duration of effects were significantly affected; selective intestinal CYP3A inhibition had minimal effects. This suggests that first-pass metabolism minimally influences OTF bioavailability. When treating breakthrough pain, with careful attention to maximal mucosal absorption and minimal swallowing, CYP3A variability and drug interactions are unlikely to affect the onset or magnitude of OTF analgesia; however, duration may be affected.

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14

Lau, Oi-Wah, and Shiu-Fai Luk. "Spectrophotometric Determination of Ascorbic Acid in Canned Fruit Juices, Cordials, and Soft Drinks with Iron(III) and 1,10-Phenanthroline as Reagents." Journal of AOAC INTERNATIONAL 70, no. 3 (May 1, 1987): 518–20. http://dx.doi.org/10.1093/jaoac/70.3.518.

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Abstract A simple and accurate spectrophotometric method has been developed for the determination of ascorbic acid in canned fruit juices, cordials, and soft drinks, based on the reduction of iron(III) by ascorbic acid to iron(II), which is then complexed with 1,10-phenanthroline. Background correction is necessary for most samples and can be achieved by copper(II)-catalyzed oxidation of the acid. The calibration graph was linear from 0 to 8 μg/mL of ascorbic acid with a slope of 0.12/ppm. The precision for the determination of ascorbic acid in a lemon drink containing 210 μg/mL of the acid was 0.9%. Many ingredients commonly found in fruit juices, cordials, and soft drinks do not interfere; however, tannic acid, pyrogallol, and sulfite interfere with the method. A wide range of samples was analyzed for ascorbic acid content by the proposed method. The samples included mango and lemon tea drinks and also grapefruit juices, for which no background correction is needed.

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Kimura, Shun-ichi, Shinichi Kako, Hidenori Wada, Kana Sakamoto, Masahiro Ashizawa, Miki Sato, Kiriko Terasako, et al. "Can grapefruit juice decrease the cost of imatinib for the treatment of chronic myelogenous leukemia?" Leukemia Research 35, no. 1 (January 2011): e11-e12. http://dx.doi.org/10.1016/j.leukres.2010.09.014.

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16

Valenzuela, Belén, Joseba Rebollo, Tania Pérez, Antonio Brugarolas, and Juan José Pérez-Ruixo. "Effect of grapefruit juice on the pharmacokinetics of docetaxel in cancer patients: a case report." British Journal of Clinical Pharmacology 72, no. 6 (November 9, 2011): 978–81. http://dx.doi.org/10.1111/j.1365-2125.2011.04052.x.

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17

Madrigal-Bujaidar, Eduardo, Laura Martino Roaro, Karol Garcia-Aguirre, Sandra Garcia-Medina, and Isela Alvarez-Gonzalez. "Grapefruit Juice Suppresses Azoxymethane-induced Colon Aberrant Crypt Formation and Induces Antioxidant Capacity in Mice." Asian Pacific Journal of Cancer Prevention 14, no. 11 (November 30, 2013): 6851–56. http://dx.doi.org/10.7314/apjcp.2013.14.11.6851.

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18

Vetrichelvan, Opalina, Priyatham Gorjala, Oscar Goodman, and Ranjana Mitra. "Bergamottin a CYP3A inhibitor found in grapefruit juice inhibits prostate cancer cell growth by downregulating androgen receptor signaling and promoting G0/G1 cell cycle block and apoptosis." PLOS ONE 16, no. 9 (September 27, 2021): e0257984. http://dx.doi.org/10.1371/journal.pone.0257984.

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Prostate cancer is the second leading cause of cancer related death in American men. Several therapies have been developed to treat advanced prostate cancer, but these therapies often have severe side effects. To improve the outcome with fewer side effects we focused on the furanocoumarin bergamottin, a natural product found in grapefruit juice and a potent CYP3A inhibitor. Our recent studies have shown that CYP3A5 inhibition can block androgen receptor (AR) signaling, critical for prostate cancer growth. We observed that bergamottin reduces prostate cancer (PC) cell growth by decreasing both total and nuclear AR (AR activation) reducing downstream AR signaling. Bergamottin’s role in reducing AR activation was confirmed by confocal microscopy studies and reduction in prostate specific antigen (PSA) levels, which is a marker for prostate cancer. Further studies revealed that bergamottin promotes cell cycle block and accumulates G0/G1 cells. The cell cycle block was accompanied with reduction in cyclin D, cyclin B, CDK4, P-cdc2 (Y15) and P-wee1 (S642). We also observed that bergamottin triggers apoptosis in prostate cancer cell lines as evident by TUNEL staining and PARP cleavage. Our data suggests that bergamottin may suppress prostate cancer growth, especially in African American (AA) patients carrying wild type CYP3A5 often presenting aggressive disease.

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Miyata, Masaaki, Hiroki Takano, Koichi Takahashi, Yu F. Sasaki, and Yasushi Yamazoe. "Suppression of 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine-induced DNA damage in rat colon after grapefruit juice intake." Cancer Letters 183, no. 1 (September 2002): 17–22. http://dx.doi.org/10.1016/s0304-3835(02)00109-x.

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20

Kim, Sung-Moo, Jong Hyun Lee, Gautam Sethi, Chulwon Kim, Seung Ho Baek, Dongwoo Nam, Won-Seok Chung, Sung-Hoon Kim, Bum Sang Shim, and Kwang Seok Ahn. "Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells." Cancer Letters 354, no. 1 (November 2014): 153–63. http://dx.doi.org/10.1016/j.canlet.2014.08.002.

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21

Miyata, M. "Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity." Carcinogenesis 25, no. 2 (October 24, 2003): 203–9. http://dx.doi.org/10.1093/carcin/bgg194.

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22

Quetglas-Llabrés, Maria Magdalena, Cristina Quispe, Jesús Herrera-Bravo, Marcelo D. Catarino, Olívia R. Pereira, Susana M. Cardoso, Kamal Dua, et al. "Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects." Oxidative Medicine and Cellular Longevity 2022 (April 25, 2022): 1–10. http://dx.doi.org/10.1155/2022/8615242.

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Bergapten (BP) or 5-methoxypsoralen (5-MOP) is a furocoumarin compound mainly found in bergamot essential oil but also in other citrus essential oils and grapefruit juice. This compound presents antibacterial, anti-inflammatory, hypolipemic, and anticancer effects and is successfully used as a photosensitizing agent. The present review focuses on the research evidence related to the therapeutic properties of bergapten collected in recent years. Many preclinical and in vitro studies have been evidenced the therapeutic action of BP; however, few clinical trials have been carried out to evaluate its efficacy. These clinical trials with BP are mainly focused on patients suffering from skin disorders such as psoriasis or vitiligo. In these trials, the administration of BP (oral or topical) combined with UV irradiation induces relevant lesion clearance rates. In addition, beneficial effects of bergamot extract were also observed in patients with altered serum lipid profiles and in people with nonalcoholic fatty liver. On the contrary, there are no clinical trials that investigate the possible effects on cancer. Although the bioavailability of BP is lower than that of its 8-methoxypsoralen (8-MOP) isomer, it has fewer side effects allowing higher concentrations to be administered. In conclusion, although the use of BP has therapeutic applications on skin disorders as a sensitizing agent and as components of bergamot extract as hypolipemic therapy, more trials are necessary to define the doses and treatment guidelines and its usefulness against other pathologies such as cancer or bacterial infections.

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23

Song, Wei, Meilin Liu, Junjun Wu, Hong Zhai, Yong Chen, and Zhihong Peng. "Preclinical Pharmacokinetics of Triptolide: A Potential Antitumor Drug." Current Drug Metabolism 20, no. 2 (April 30, 2019): 147–54. http://dx.doi.org/10.2174/1389200219666180816141506.

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Background:Triptolide, a bioactive component in Tripterygium wilfordii extracts, possess strong antiproliferative activity on all 60-National Cancer Institute (NCI) cancer cell lines. However, the widespread use of triptolide in the clinical practice is greatly limited for its multi-organ toxicity and narrow therapeutic window. All the toxic characteristics of triptolide are associated with the pharmacokinetics especially its distribution and accumulation in the target organ.Methods:The literature review was done using PubMed search, SciFinder and Google Scholar databases with specific keywords such as triptolide, pharmacokinetics, drug-drug interaction, transporters, metabolism, modification to collect the related full-length articles and abstracts from 2000 to 2018.Results:Oral triptolide is rapidly and highly absorbed. Grapefruit juice affects oral absorption, increasing the area under the concentration-time curve (AUC) by 153 % and the maximum concentration (Cmax) by 141 %. The AUC and the Cmax are not dose proportional. Triptolide distributes into the liver, heart, spleen, lung and kidney. Biotransformation of triptolide in rats includes hydroxylation, sulfate, glucuronide, N-acetylcysteine (NAC) and Glutathione (GSH) conjugation and combinations of these pathways. Less than 4 % of triptolide was recovered from the feces, bile and urine within 24 h. After repeating dosage, triptolide was eliminated quickly without accumulation in vivo. As a substrate of P-glycoprotein (P-gp) and CYP3A4, triptolide could have clinically significant pharmacokinetic interactions with those proteins substrates/inhibitors.Conclusion:The findings of this review confirm the importance of pharmacokinetic character for understanding the pharmacology and toxicology of triptolide.

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Hill, Emily, Anna Pashkova, Elizabeth Grainger, Kristen Roberts, Chureeporn Chitchumroonchokchai, Steven Clinton, and Colleen Spees. "Associations Between a Targeted Metabolomics Panel of Urinary Flavonoids and Flavonoid Intakes from Fruits and Vegetables Across Dietary Assessment Periods." Current Developments in Nutrition 5, Supplement_2 (June 2021): 322. http://dx.doi.org/10.1093/cdn/nzab037_032.

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Abstract Objectives Aligning dietary intake and food composition data with biomarkers of exposure is critical for advancing assessment methodology. Flavonoids present in fruits and vegetables (FV) are rapidly metabolized and excreted in urine; therefore they may serve as acute intake biomarkers. Yet, the optimal dietary assessment period has not been determined. The objective of this study was to evaluate associations between a targeted metabolomics panel of six urinary flavonoids and dietary intakes of these flavonoids from FV across varying dietary assessment periods. Methods In this cross-sectional study, three-day diet records from 17 individuals were analyzed via Nutrition Data System for Research to determine FV intakes over one-day, two-day, and three-day assessment periods. Dietary flavonoids from FV were estimated via the Phenol-Explorer database; total intakes of targeted flavonoids (quercetin, kaempferol, isorhamnetin, phloretin, naringenin, hesperetin) were calculated by summing aglycone and glycosylated forms. Twenty-four-hour (24-h) urine was collected on the final day of diet records. Urinary flavonoid aglycones were quantified using HPLC; total urinary flavonoids were calculated by summing targeted flavonoids. Spearman correlations between flavonoid intakes and urinary flavonoids were analyzed by dietary assessment period. Results Mean targeted flavonoid intake from FV was 53.6 mg/day. Ten specific FV provided >95% of dietary flavonoids, with greatest contributions from citrus (orange juice, grapefruit, orange) and onion. Mean urinary flavonoid excretion was 9.5 μmol/24-h. Urinary flavonoids were moderately associated with flavonoid intakes from the one-day assessment period on the day prior to urine collection (rs = 0.485, P = 0.048) and summed intakes from the two-day assessment period (rs = 0.598, P = 0.011), but not from intakes over the three-day assessment period. Conclusions Urinary flavonoids are most strongly associated with dietary flavonoids consumed within two days of 24-h urine collection, indicating two-day diet records aligned with 24-h urine collection is optimal for assessing (poly)phenol exposure from FV in future research. Funding Sources OSU CCTS, Rosita Schiller Award, OSU Comprehensive Cancer Center MCC Program, and OSU CAFFRE.

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25

"Broccoli and grapefruit - part 2." Arbor Clinical Nutrition Updates 257 (July 2006): 1–3. http://dx.doi.org/10.1017/s1446545000000713.

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In a nutshellGrapefruit can prolong the half life of various drugs, such as statins and benzodiapenes.There is also reason to believe that grapefruit - either as juice or the whole fruit - has potential to lower cancer risk, improve insulin response and cardiovascular risk factors, and possibly even help lose weight.

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Garaeva, Luiza, Roman Kamyshinsky, Yury Kil, Elena Varfolomeeva, Nikolai Verlov, Elena Komarova, Yuri Garmay, et al. "Delivery of functional exogenous proteins by plant-derived vesicles to human cells in vitro." Scientific Reports 11, no. 1 (March 22, 2021). http://dx.doi.org/10.1038/s41598-021-85833-y.

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AbstractPlant-derived extracellular vesicles (EVs) gain more and more attention as promising carriers of exogenous bioactive molecules to the human cells. Derived from various edible sources, these EVs are remarkably biocompatible, biodegradable and highly abundant from plants. In this work, EVs from grapefruit juice were isolated by differential centrifugation followed by characterization of their size, quantity and morphology by nanoparticle tracking analysis, dynamic light scattering, atomic force microscopy and cryo-electron microscopy (Cryo-EM). In Cryo-EM experiments, we visualized grapefruit EVs with the average size of 41 ± 13 nm, confirmed their round-shaped morphology and estimated the thickness of their lipid bilayer as 5.3 ± 0.8 nm. Further, using cell culture models, we have successfully demonstrated that native grapefruit-derived extracellular vesicles (GF-EVs) are highly efficient carriers for the delivery of the exogenous Alexa Fluor 647 labeled bovine serum albumin (BSA) and heat shock protein 70 (HSP70) into both human peripheral blood mononuclear cells and colon cancer cells. Interestingly, loading to plant EVs significantly ameliorated the uptake of exogenous proteins by human cells compared to the same proteins without EVs. Most importantly, we have confirmed the functional activity of human recombinant HSP70 in the colon cancer cell culture upon delivery by GF-EVs. Analysis of the biodistribution of GF-EVs loaded with 125I-labeled BSA in mice demonstrated a significant uptake of the grapefruit-derived extracellular vesicles by the majority of organs. The results of our study indicate that native plant EVs might be safe and effective carriers of exogenous proteins into human cells.

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Madrigal-Bujaidar, Eduardo, Edilberto Pérez-Montoya, Sandra García-Medina, José Melesio Cristóbal-Luna, José A. Morales-González, Eduardo Osiris Madrigal-Santillán, Rogelio Paniagua-Pérez, and Isela Álvarez-González. "Pharmacokinetic parameters of ifosfamide in mouse pre-administered with grapefruit juice or naringin." Scientific Reports 9, no. 1 (November 12, 2019). http://dx.doi.org/10.1038/s41598-019-53204-3.

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Abstract Grapefruit juice (GFJ) and naringin when consumed previously or together with medications may alter their bioavailavility and consequently the clinical effect. Ifosfamide (IF) is an antitumoral agent prescribed against various types of cancer. Nevertheless, there is no information regarding its interaction with the ingestion of GFJ or naringin. The aims of the present report were validating a method for the quantitation of IF in the plasma of mouse, and determine if mice pretreated with GFJ or naringin may modify the IF pharmacokinetics. Our HPLC results to quantify IF showed adequate intra and inter-day precision (RSD < 15%) and accuracy (RE < 15%) indicating reliability. Also, the administration of GFJ or naringin increased Cmax of IF 22.9% and 17.8%, respectively, and decreased Tmax of IF 19.2 and 53.8%, respectively. The concentration of IF was higher when GFJ (71.35 ± 3.5 µg/mL) was administered with respect to that obtained in the combination naringin with IF (64.12 ± µg/mL); however, the time required to reach such concentration was significantly lower when naringin was administered (p < 0.5). We concluded that pre-administering GFJ and naringin to mice increased the Tmax and decreased the Cmax of IF.

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Long, Zhangbiao, Min Ruan, Wei Wu, Qingshu Zeng, Qingsheng Li, and Zhengqi Huang. "The successful combination of grapefruit juice and venetoclax in an unfit acute myeloid leukemia patient with adverse risk: A case report." Frontiers in Oncology 12 (September 28, 2022). http://dx.doi.org/10.3389/fonc.2022.912696.

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Venetoclax combined with hypomethylating agents such as azacitidine and decitabine is the standard regime for the elderly patient with acute myeloid leukemia (AML) unfit for intensive induction therapy. However, many patients struggle with finances and forgo treatments due to the high costs of venetoclax. In this study, we performed the regime with azacitidine, low-dose venetoclax, and grapefruit juice on an unfit AML patient with TP53 mutation. The peak venetoclax concentration (Cmax) and side effects on the patient were also monitored. The patient achieved complete remission with the venetoclax Cmax within the effective concentration range (1,000–3,000 ng/ml) and maintained durable remission until recently. Febrile neutropenia, thrombocytopenia, and pneumonia appeared during the first cycle and were recovered by stimulating agents and antibiotic treatment. This improvement combination approach by drug-food interaction may enlighten other similarly patients with AML, especially those in low-middle income countries.

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Luo, Wenzheng, Zhenyu Song, Hongwei Sun, Junxin Liang, and Shanshan Zhao. "Bergamottin, a natural furanocoumarin abundantly present in grapefruit juice, suppresses the invasiveness of human glioma cells via inactivation of Rac1 signaling." Oncology Letters, December 19, 2017. http://dx.doi.org/10.3892/ol.2017.7641.

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