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Journal articles on the topic 'Canthin-6-one'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Ng, Mei Fong, Juliana Da Silva Viana, Pei Jean Tan, et al. "Canthin-6-One Inhibits Developmental and Tumour-Associated Angiogenesis in Zebrafish." Pharmaceuticals 17, no. 1 (2024): 108. http://dx.doi.org/10.3390/ph17010108.

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Tumour-associated angiogenesis play key roles in tumour growth and cancer metastasis. Consequently, several anti-angiogenic drugs such as sunitinib and axitinib have been approved for use as anti-cancer therapies. However, the majority of these drugs target the vascular endothelial growth factor A (VEGFA)/VEGF receptor 2 (VEGFR2) pathway and have shown mixed outcome, largely due to development of resistances and increased tumour aggressiveness. In this study, we used the zebrafish model to screen for novel anti-angiogenic molecules from a library of compounds derived from natural products. Fro

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2

Li, Yongchun, Meirong Zhao, and Zhi Zhang. "Quantitative proteomics reveals the antifungal effect of canthin-6-one isolated from Ailanthus altissima against Fusarium oxysporum f. sp. cucumerinum in vitro." PLOS ONE 16, no. 4 (2021): e0250712. http://dx.doi.org/10.1371/journal.pone.0250712.

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Canthin-6-one, one of the main alkaloid compounds extracted from Ailanthus altissima, has recently attracted increasing interest for its antifungal activity. To evaluate the potential of canthin-6-one in controlling plant fungal diseases, we investigated the antifungal activity of canthin-6-one isolated from A. altissima against Fusarium oxysporum f. sp. cucumerinum (Foc) in vitro. The mycelial growth rate and micro-broth dilution were used to test antifungal activity. Furthermore, label-free quantitative proteomics and parallel reaction monitoring (PRM) techniques were applied to analyze the

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3

Harris, A., L. Anderson, J. Phillipson, and R. Brown. "Canthin-6-one Alkaloids fromBrucea antidysentericaRoot Bark." Planta Medica 51, no. 02 (1985): 151–53. http://dx.doi.org/10.1055/s-2007-969432.

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4

Mitsunaga, Katsuyoshi, Kazuo Koike, Tomoko Tanaka, et al. "Canthin-6-one alkaloids from Eurycoma longifolia." Phytochemistry 35, no. 3 (1994): 799–802. http://dx.doi.org/10.1016/s0031-9422(00)90609-5.

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5

Sen’ko, O. A., A. G. Dybenko, M. M. Garazd, and V. G. Kartsev. "Synthesis of Benzoannelated Canthin-6-One Analogs." Chemistry of Natural Compounds 53, no. 3 (2017): 523–28. http://dx.doi.org/10.1007/s10600-017-2037-9.

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6

Czerwinski, Kevin M., Craig A. Zificsak, John Stevens, et al. "An Improved Synthesis of Canthin-6-one." Synthetic Communications 33, no. 7 (2003): 1225–31. http://dx.doi.org/10.1081/scc-120017199.

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7

Barbetti, P., G. Grandolini, G. Fardella, I. Chiappini, and A. Mastalia. "New Canthin-6-one Alkaloids fromQuassia amara." Planta Medica 56, no. 02 (1990): 216–17. http://dx.doi.org/10.1055/s-2006-960928.

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8

Vanhaelen-Fastré, R., M. Vanhaelen, B. Diallo, and H. Breyne. "Canthin-6-one Alkaloids fromPierreodendron africanumStem Barks." Planta Medica 56, no. 02 (1990): 241–42. http://dx.doi.org/10.1055/s-2006-960941.

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9

Fo, Edson Rodrigues, João B. Fernandes, Paulo C. Vieira, and M. Fátima das G.F. da Silva. "Canthin-6-one alkaloids from Picrolemma granatensis." Phytochemistry 31, no. 7 (1992): 2499–501. http://dx.doi.org/10.1016/0031-9422(92)83309-m.

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10

de Bilbao, Ninfa Vera, Ryland T. Giebelhaus, Ryan P. Dias, et al. "Exploring the Anti-Chagas Activity of Zanthoxylum chiloperone’s Seedlings Through Metabolomics and Protein–Ligand Docking." Plants 14, no. 6 (2025): 954. https://doi.org/10.3390/plants14060954.

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This publication reports the controlled cultivation of Zanthoxylum chiloperone var. angustifolium Engl. (Rutaceae) in several growth substrates under controlled greenhouse conditions. This plant is well-known for its anti-Chagas (trypanocidal) activity, related to the presence of several β-carboline alkaloids. The metabolomic study of Z. chiloperone seedlings over two years of growth (2018–2020) was performed using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS). The canthin-6-one alkaloids, canthin-6-one and 5-methoxy-canthin-6-one, were putat

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11

Qi, Xubing, Yogini Jaiswal, Xinrong Xie, et al. "Synthesis and Antimicrobial Activity of Canthin-6-One Alkaloids." Molecules 30, no. 7 (2025): 1546. https://doi.org/10.3390/molecules30071546.

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Canthin-6-one alkaloids have consistently attracted the interest of medicinal chemists due to their wide range of promising bioactivities, including antitumor, antifungal, antibacterial, and antiviral properties. However, their low natural abundance in plants has constrained the further exploration of their potential bioactivities. This study reports a comprehensive synthesis of canthin-6-one alkaloids, utilizing key Suzuki coupling and Cu-catalyzed amidation reactions to construct their core scaffold. Derivatives were synthesized with Koenig–Knorr glycosylation for the further modification of

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12

Li, Na, Dan Liu, Jiang-Kun Dai, Jin-Yi Wang, and Jun-Ru Wang. "Synthesis and In Vitro Antibacterial Activity of Quaternized 10-Methoxycanthin-6-one Derivatives." Molecules 24, no. 8 (2019): 1553. http://dx.doi.org/10.3390/molecules24081553.

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Background: Based on our previous work, we found that 10-methoxycanthin-6-one displayed potential antibacterial activity and quaternization was an available method for increasing the antibacterial activity. Here, we explored the antibacterial activity of quaternized 10-methoxy canthin-6-one derivatives. Methods and Results: Twenty-two new 3-N-benzylated 10-methoxy canthin-6-ones were designed and synthesized through quaternization reaction. The in vitro antibacterial activity against three bacteria was evaluated by the double dilution method. Moreover, the structure–activity relationships (SAR

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13

Ikuta, Akira, and Takayuki Nakamura. "Canthin-6-one from the Roots ofPhellodendron amurense." Planta Medica 61, no. 06 (1995): 581–82. http://dx.doi.org/10.1055/s-2006-959384.

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14

Krauss, Gudrun, Gerd-Joachim Krauss, Renate Baumbach, and Detlef Gröger. "Elicitation of Canthin-6-one Alkaloid Accumulation in Cell Suspension Cultures of Ailanthus altissima (Mill.) Swingle." Zeitschrift für Naturforschung C 44, no. 7-8 (1989): 712–14. http://dx.doi.org/10.1515/znc-1989-7-826.

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Cell suspension cultures of Ailanthus altissima (Simaroubaceae) were cultivated under illumination and in the dark. Under influence of a yeast elicitor and cell wall preparations of various Phytophthora species, respectively, alkaloid formation was stimulated. Canthin-6-one and 1- methoxycanthin-6-one accumulation could be increased up to a 125-fold and 2.5-fold, respectively within 96 h by elicitors in dark grown cultures. In response to elicitors canthin-6-one is accumulated in the cells and the growth medium.

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15

Dang, Nguyen Hai, Do Thi Ngoc Lan, Nguyen Thi Thu Minh, et al. "Quassinoids and Alkaloids From the Roots of Eurycoma longifolia." Natural Product Communications 14, no. 5 (2019): 1934578X1985069. http://dx.doi.org/10.1177/1934578x19850695.

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Five quassinoids and 2 alkaloids were isolated from the roots of Eurycoma longifolia. The structures of 3 new quassinoids, eurycomalide F, G, and H (1-3), were elucidated using a variety of spectroscopic methods. The known compounds were identified as eurycomalide A (4), laurycolactone B (5), 5-methoxycanthin-6-one (6), and canthin-6-one (7). Among the isolated compounds, canthin-6-one (7) exhibited the strongest inhibitory effect on nitric oxide production (IC50 = 16.9 μM). 5-Methoxycanthin-6-one (6) and eurycomalide F (1) exhibited weak inhibition with IC50 values of 23.4 and 32.7 μM, respec

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16

Jiang, Mei-Xiang, and Ying-Jun Zhou. "Canthin-6-one alkaloids fromPicrasma quassioidesand their cytotoxic activity." Journal of Asian Natural Products Research 10, no. 11 (2008): 1009–12. http://dx.doi.org/10.1080/10286020802277956.

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17

Ouyang, Yishan, Kazuo Koike, and Taichi Ohmoto. "Canthin-6-one alkaloids from Brucea mollis var. Tonkinensis." Phytochemistry 36, no. 6 (1994): 1543–46. http://dx.doi.org/10.1016/s0031-9422(00)89758-7.

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18

Zapesochnaya, Gertruda, Vladimir Kurkin, Victor Okhanov та Anatoly Miroshnikov. "Canthin-6-one and β-Carboline Alkaloids fromAerva lanata". Planta Medica 58, № 02 (1992): 192–96. http://dx.doi.org/10.1055/s-2006-961427.

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19

Sakdamas, Attapon, Fonthip Makliang, Waraporn Putalun, et al. "Analysis of canthin-6-one alkaloids derived from Eurycoma spp. by micellar liquid chromatography and conventional high-performance liquid chromatography: a comparative evaluation." RSC Advances 13, no. 9 (2023): 6317–26. http://dx.doi.org/10.1039/d2ra07034k.

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20

Kanchanapoom, Tripetch, Ryoji Kasai, Phannipha Chumsri, Yoshikazu Hiraga та Kazuo Yamasaki. "Canthin-6-one and β-carboline alkaloids from Eurycoma harmandiana". Phytochemistry 56, № 4 (2001): 383–86. http://dx.doi.org/10.1016/s0031-9422(00)00363-0.

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21

Rößler, Ulrich, Siegfried Blechert, and Eberhard Steckhan. "Single electron transfer induced total synthesis of canthin-6-one." Tetrahedron Letters 40, no. 39 (1999): 7075–78. http://dx.doi.org/10.1016/s0040-4039(99)01472-0.

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22

Diakanamwa, C., B. Diallo, R. Vanhaelen-Fastré та M. Vanhaelen. "Canthin-6-one and β-Carboline Alkaloids fromHannoa chloranthaRoot Bark". Planta Medica 58, № 03 (1992): 298. http://dx.doi.org/10.1055/s-2006-961467.

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23

Arias, José L., Gerardo Cebrián-Torrejón, Erwan Poupon, Alain Fournet, and Patrick Couvreur. "Biodegradable polymeric nanoformulation based on the antiprotozoal canthin-6-one." Journal of Nanoparticle Research 13, no. 12 (2011): 6737–46. http://dx.doi.org/10.1007/s11051-011-0580-z.

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24

O'Donnell, Gemma, and Simon Gibbons. "Antibacterial activity of two canthin-6-one alkaloids fromAllium neapolitanum." Phytotherapy Research 21, no. 7 (2007): 653–57. http://dx.doi.org/10.1002/ptr.2136.

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25

Kaigongi, Magrate M., Catherine W. Lukhoba, Souaibou Yaouba, Nokwanda P. Makunga, Joseph Githiomi, and Abiy Yenesew. "In Vitro Antimicrobial and Antiproliferative Activities of the Root Bark Extract and Isolated Chemical Constituents of Zanthoxylum paracanthum Kokwaro (Rutaceae)." Plants 9, no. 7 (2020): 920. http://dx.doi.org/10.3390/plants9070920.

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Zanthoxylum paracanthum Kokwaro (Rutaceae) is an endemic Kenyan and Tanzanian plant used in folk medicine by local populations. Although other Zanthoxylum species have been studied, only Z. paracantum stem extracts have been profiled, even though the roots are also used as herbal remedies. As root extracts may be another source of pharmaceutical compounds, the CH2Cl2/MeOH (1:1) root bark extract was studied in this report. Eight root bark compounds were isolated and their structural identities were confirmed by mass spectrometry (MS) and nuclear magnetic resonance (NMR) (using COSY, HSQC, NOES

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26

Dinesh, Kawade* Sejal Kshirsagar Shriya Bagh Shikha Shahu Yashika Bhattad. "Virtual Screening of Aerva Lanta On 7dfl Receptor for Antiasthamatic Activity." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2303–27. https://doi.org/10.5281/zenodo.15241829.

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Based on the provided data on the toxicity of various ligands with varying MW, lipkinski’s rule of five violations, bioavailability scores, lead likeness violations were analyzed and the following conclusions can be drawn: Rutin, Narcissin, and Canthin-6-one exhibit significant toxicity, particularly in terms of carcinogenicity and hypertoxicity. Quercetin, Myricetin, Isorhamnetin, Kaempferol, Feru loylty ramine, Ferulic acid, Gallic acid, P- Coumaric acid, and Apigetrin show varying levels of toxicity, but generally are less toxic compared to Rutin, Narcissin, and Canthin-6-one. Metherg

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27

KOIKE, KAZUO, and TAICHI OHMOTO. "Carbon-13 nuclear magnetic resonance study of canthin-6-one alkaloids." CHEMICAL & PHARMACEUTICAL BULLETIN 33, no. 12 (1985): 5239–44. http://dx.doi.org/10.1248/cpb.33.5239.

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28

Cho, Seung-Kye, Miran Jeong, Dae Jang, and Jung-Hye Choi. "Anti-inflammatory Effects of Canthin-6-one Alkaloids from Ailanthus altissima." Planta Medica 84, no. 08 (2017): 527–35. http://dx.doi.org/10.1055/s-0043-123349.

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AbstractCanthin-6-one (CO) alkaloids possess various biological activities, including antibacterial, antitumor, antifungal, and antiviral activities. However, their anti-inflammatory effects and underlying molecular mechanisms are poorly characterized. This study aimed to investigate the anti-inflammatory effects of CO and its derivative 5-(1-hydroxyethyl)-canthin-6-one (5-HCO), isolated from the stem barks of Ailanthus altissima in lipopolysaccharide (LPS)-stimulated macrophages. CO (1 and 5 µM) and 5-HCO (7.5 and 15 µM) significantly inhibited the LPS-induced expression of inducible nitric o

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29

Karin, Chiung-Sheue Liu, Shi-Lin Yang, Margaret F. Roberts, and J. David Phillipson. "Canthin-6-one alkaloids from cell suspension cultures of Brucea javanica." Phytochemistry 29, no. 1 (1990): 141–43. http://dx.doi.org/10.1016/0031-9422(90)89027-7.

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30

Sakdamas, Attapon, Fonthip Makkliang, Waraporn Putalun, et al. "Correction: Analysis of canthin-6-one alkaloids derived from Eurycoma spp. by micellar liquid chromatography and conventional high-performance liquid chromatography: a comparative evaluation." RSC Advances 13, no. 20 (2023): 13928. http://dx.doi.org/10.1039/d3ra90044d.

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Correction for ‘Analysis of canthin-6-one alkaloids derived from Eurycoma spp. by micellar liquid chromatography and conventional high-performance liquid chromatography: a comparative evaluation’ by Attapon Sakdamas et al., RSC Adv., 2023, 13, 6317–6326, https://doi.org/10.1039/D2RA07034K.

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31

López, Carlos, Manuel Pastrana, Alexandra Ríos, Alvaro Cogollo, and Adriana Pabón. "Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi." Molecules 23, no. 4 (2018): 934. http://dx.doi.org/10.3390/molecules23040934.

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32

dos Santos Costa, Rafael, Renan Fernandes do Espírito‐Santo, Lucas Silva Abreu, et al. "Fluorescent Canthin‐6‐one Alkaloids fromSimaba bahiensis: Isolation, Identification, and Cell‐Labeling Properties." ChemPlusChem 84, no. 3 (2019): 260–67. http://dx.doi.org/10.1002/cplu.201800591.

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33

Codding, Penelope W., Maria B. Szkaradzinska, Aleksander W. Roszak, Lorraine J. Aha, Timothy J. Hagen та James M. Cook. "Structure-activity studies of β-carbolines. 4. Crystal and molecular structures of t-butyl β-carboline-3-carboxylate and 2-(methoxycarbonyl)canthine-6-one". Canadian Journal of Chemistry 66, № 12 (1988): 2981–88. http://dx.doi.org/10.1139/v88-463.

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The crystal and molecular structures of two ligands for the benzodiazepine (BZ) receptor, t-butyl β-carboline-3-carboxylate, I (C16H16N2O2), and 2-(methoxycarbonyl)canthin-6-one, II (C16H10N2O3), are reported. The t-butyl β-carboline compound has high affinity for the receptor and is an antagonist; in contrast, the canthin-6-one has a 10-fold lower affinity for the receptor and no determinable in vivo activity. The space group for I is P21/c with a = 11.756(1), b = 11.2324(8), c = 11.964(1) Å, and β = 105.99(1)°. For II, the space group is also P21/c with a = 9.317(1), b = 7.964(1), c = 17.180

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34

Ferreira, Maria Elena, Hector Nakayama, Antonieta Rojas de Arias, et al. "Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice." Journal of Ethnopharmacology 109, no. 2 (2007): 258–63. http://dx.doi.org/10.1016/j.jep.2006.07.028.

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35

Zhang, Ying, Wei Zhao, Jingya Ruan, et al. "Anti-inflammatory canthin-6-one alkaloids from the roots of Thailand Eurycoma longifolia Jack." Journal of Natural Medicines 74, no. 4 (2020): 804–10. http://dx.doi.org/10.1007/s11418-020-01433-6.

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36

Soriano-Agatón, Flor, Delphine Lagoutte, Erwan Poupon, et al. "Extraction, Hemisynthesis, and Synthesis of Canthin-6-one Analogues. Evaluation of Their Antifungal Activities." Journal of Natural Products 68, no. 11 (2005): 1581–87. http://dx.doi.org/10.1021/np050250z.

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37

Hassan, Nor Hasnida, Sui Kiong Ling, Nazirah Abdullah, and Nur Aini Mohd Kassim. "Production of Canthin-6-One and Stigmasterol in Eurycoma Longifolia (Tongkat Ali) Jack. Hairy Root Culture Transformed Using Agrobacterium Rhizogenes Strain A4." Sains Malaysiana 54, no. 5 (2025): 1221–29. https://doi.org/10.17576/jsm-2025-5405-02.

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Eurycoma longifolia, commonly known as Tongkat Ali or Malaysian ginseng, contains a variety of chemical compounds, including quassinoids, canthin-6-one alkaloids, B-carboline alkaloids, squalene derivatives, and steroids. These compounds contribute to the plant's therapeutic properties, which include anti-cancer, anti-malarial, anti-ulcer, aphrodisiac, and energy-boosting effects. Since many of these compounds are primarily extracted from the roots, overharvesting can threaten wild populations of E. longifolia. A sustainable approach to producing these chemical compounds involves cultivating h

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38

Heba, Ibrahim Abd El-Moaty. "INVESTIGATION OF SOME ACTIVE CONSTITUENTS OF EUPHORBIA BIVONAE STEUD." IAJPS,CSK PUBLICATIONS 03, no. 11 (2016): 1309–15. https://doi.org/10.5281/zenodo.179177.

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The investigation of some active constituents of Euphorbia bivonae included terpenes, alkaloids, coumarins and anthraquinones to evaluate its economic values as medicinal plant, where sugiol and betulin compounds were isolated from the aerial parts and roots of Euphorbia bivonae, while ferruginol compound was isolated only from the roots. The total terpenes content of the aerial parts and roots of E. bivonae were 3.44 and 8.96 mg/g, respectively, which were estimated spectrophotometrically. Meanwhile, the compounds 2Piperidinone, N[4bromonbutyl] and komaroine were isolated from the aerial part

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39

Doménech-Carbó, Antonio, Regina Rodrigo, Jean-Didier Maréchal та ін. "Bioelectrochemical monitoring of soluble guanylate cyclase inhibition by the natural β-carboline canthin-6-one". Journal of Molecular Structure 1134 (квітень 2017): 661–67. http://dx.doi.org/10.1016/j.molstruc.2016.12.016.

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40

Takahashi, Hideaki, Shin-ichiro Kurimoto, Jun'ichi Kobayashi, and Takaaki Kubota. "Ishigadine A, a new canthin-6-one alkaloid from an Okinawan marine sponge Hyrtios sp." Tetrahedron Letters 59, no. 51 (2018): 4500–4502. http://dx.doi.org/10.1016/j.tetlet.2018.11.019.

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41

Suzuki, Hideharu, Makoto Adachi, Yuki Ebihara та ін. "A Total Synthesis of 1-Methoxycanthin-6-one: An Efficient One-Pot Synthesis of the Canthin-6-one Skeleton from β-Carboline-1-carbaldehyde". Synthesis 2005, № 01 (2004): 28–32. http://dx.doi.org/10.1055/s-2004-834915.

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42

Chen, Yuanyuan, Zongying Zhang, Yuan Yao, et al. "Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression." Current Issues in Molecular Biology 47, no. 1 (2025): 38. https://doi.org/10.3390/cimb47010038.

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Rheumatoid arthritis (RA) is an autoimmune disorder that leads to severe cartilage deterioration and synovial impairment in the joints. Previous studies have indicated that the aberrant activation of the NLRP3 inflammasome in synovial macrophages plays a significant role in the pathogenesis of RA and has been regarded as a therapeutic target for the disease. In this study, we synthesized a novel canthin-6-one alkaloid, namely methyl canthin-6-one-2-carboxylate (Cant), and assessed its effects on NLRP3 inflammasome activation in macrophages. Our data reveal that exposure to Cant significantly s

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43

Miyake, Katsunori, Yasuhiro Tezuka, Suresh Awale, Feng Li, and Shigetoshi Kadota. "Canthin-6-one Alkaloids and a Tirucallanoid from Eurycoma longifolia and Their Cytotoxic Activity against a Human HT-1080 Fibrosarcoma Cell Line." Natural Product Communications 5, no. 1 (2010): 1934578X1000500. http://dx.doi.org/10.1177/1934578x1000500105.

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Phytochemical investigation of the stems of Eurycoma longifolia Jack led to the isolation of two new canthin-6-one alkaloids, 4,9-dimethoxycanthin-6-one (1) and 10-hydroxy-11-methoxycanthin-6-one (2), and a new tirucallane-type triterpenoid, 23,24,25-trihydroxytirucall-7-en-3,6-dione (3), along with 37 known compounds. Among these, an oxasqualenoid (4) was isolated as a natural product for the first time. The structures of the isolates were elucidated by spectroscopic and mass spectrometric means. All the isolates were evaluated for their cytotoxic activity against a HT-1080 human fibrosarcoma

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44

Noldin, Vânia Floriani, Domingos Tabajara de Oliveira Martins, César Marcos Marcello, Joaquim Corsino da Silva Lima, Franco Delle Monache, and Valdir Cechinel Filho. "Phytochemical and Antiulcerogenic Properties of Rhizomes from Simaba ferruginea St. Hill. (Simaroubaceae)." Zeitschrift für Naturforschung C 60, no. 9-10 (2005): 701–6. http://dx.doi.org/10.1515/znc-2005-9-1007.

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Abstract Simaba ferruginea (Simaroubaceae) is a Brazilian medicinal plant used in traditional medicine to treat several ailments, including gastric ulcers, fever, diarrhea, and dolorous and inflammatory processes. This study examines the chemical composition and antiulcerogenic effects of rhizomes from this plant. Bioassay-guided fractionation led to the isolation of two bioactive indole alkaloids called canthin-6-one (1) and 4-methoxycanthin-6-one (2). The alkaloid fraction and both alkaloids demonstrated potent antiulcerogenic effects when evaluated in gastric lesion-induced animals, as well

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45

Ajala, O. S., P. U. Okechukwu, D. O. Innocent-Ugwu, and O. H. Dada. "<i>In Silico</i> Identification of Canthin-6-one as a Pancreatic Lipase Inhibitory Anti-Obesity Drug Lead from <i>Hibiscus Sabdariffa</i>." Nigerian Journal of Pharmaceutical Research 20, no. 1 (2024): 57–68. http://dx.doi.org/10.4314/njpr.v20i1.7.

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Background: The therapeutic use of the only Pancreatic Lipase (PL) - inhibiting anti-obesity drug available in clinical practice, orlistat, is bedevilled with unbearable side effects, necessitating the discovery of new and better-tolerated ones. Hibiscus sabdariffa, a folkloric anti- obesity plant is a plausible repertoire from which such agents could be sought. Objective: The main objective of this work was to evaluate in silico the phytochemicals of Hibiscus sabdariffa for a possible identification of potential leads for PL inhibitory anti-obesity drug discovery. Methods: Phytoligands from H

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Yaluff, Gloria, Gisel Piris, Kristha Paredes, et al. "Evaluación genotóxica de las moléculas con efectos tripanocida y leishmanicida cantin-6-ona y 5-metoxicantin-6-ona en células de médula ósea de ratones." Memorias del Instituto de Investigaciones en Ciencias de la Salud 18, no. 1 (2020): 69–75. http://dx.doi.org/10.18004/mem.iics/1812-9528/2020.018.01.69-075.

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Cebrián-Torrejón, Gerardo, Suzana Assad Kahn, Maria Elena Ferreira, et al. "Alkaloids from Rutaceae: activities of canthin-6-one alkaloids and synthetic analogues on glioblastoma stems cells." MedChemComm 3, no. 7 (2012): 771. http://dx.doi.org/10.1039/c2md20047c.

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Ferreira, M. E., A. Rojas de Arias, S. Torres de Ortiz, et al. "Leishmanicidal activity of two canthin-6-one alkaloids, two major constituents of Zanthoxylum chiloperone var. angustifolium." Journal of Ethnopharmacology 80, no. 2-3 (2002): 199–202. http://dx.doi.org/10.1016/s0378-8741(02)00025-9.

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Vieira Torquato, Heron F., Antonio C. Ribeiro-Filho, Marcus V. Buri, et al. "Canthin-6-one induces cell death, cell cycle arrest and differentiation in human myeloid leukemia cells." Biochimica et Biophysica Acta (BBA) - General Subjects 1861, no. 4 (2017): 958–67. http://dx.doi.org/10.1016/j.bbagen.2017.01.033.

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Chen, Karin Chiung-Sheue, Hui-Li Chang, Mei-Ling Chan, and Shoei-Sheng Lee. "A Novel Canthin-6-One Alkaloid Isolated from Cell Suspension Cultures of Brucea Javanica (L.) Merr." Journal of the Chinese Chemical Society 40, no. 4 (1993): 403–5. http://dx.doi.org/10.1002/jccs.199300063.

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