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Dissertations / Theses on the topic 'Cantor sets'
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Clark, Thomas Tyler. "Continued Radicals and Cantor Sets." TopSCHOLAR®, 2012. http://digitalcommons.wku.edu/theses/1145.
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We examine the formation of sets homeomorphic to the ternary Cantor set by continued radicals. We determine properties of bridges and gaps and calculate the thickness of the Cantor set. From this we apply information from continued fractions to continued radicals to obtain new results. We also consider the measure of several Cantor sets.
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Salp, Cem. "Metric diophantine approximation and cantor sets." Thesis, University of York, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444750.
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Pearson, John Clifford. "The noncommutative geometry of ultrametric cantor sets." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24657.
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Thesis (Ph.D.)--Mathematics, Georgia Institute of Technology, 2008.Committee Chair: Bellissard, Jean; Committee Member: Baker, Matt; Committee Member: Bakhtin, Yuri; Committee Member: Garoufalidis, Stavros; Committee Member: Putnam, Ian
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Astels, Stephen. "Cantor sets and numbers with restricted partial quotients." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0017/NQ38215.pdf.
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McCoy, Ted. "Upper and Lower Densities of Cantor Sets using Blanketed Hausdorff Functions." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1038902284.
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Pearsall, Sam Alfred. "The Cantor set." CSUSB ScholarWorks, 1999. https://scholarworks.lib.csusb.edu/etd-project/1528.
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Roinestad, Kristine A. "Geometry of Self-Similar Sets." Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/32581.
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This paper examines self-similar sets and some of their properties,
including the natural equivalence relation found in bilipschitz
equivalence. Both dimension and preservation of paths are determined
to be invariant under this equivalence. Also, sophisticated
techniques, one involving the use of directed graphs, show the
equivalence of two spaces.Master of Science
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Phillips, Jason D. "Intersections of Deleted Digits Cantor Sets With Their Translates." Wright State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=wright1308100597.
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Shaw, Vincent T. "Intersections of Deleted Digits Cantor Sets with Gaussian Integer Bases." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1588311633767137.
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Arzt, Peter [Verfasser]. "Eigenvalues of measure theoretic Laplacians on Cantor-like sets / Peter Arzt." Siegen : Universitätsbibliothek der Universität Siegen, 2014. http://d-nb.info/1058733621/34.
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Naughton, Gerard P. (Gerard Peter). "Haar Measure on the Cantor Ternary Set." Thesis, University of North Texas, 1990. https://digital.library.unt.edu/ark:/67531/metadc504018/.
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The purpose of this thesis is to examine certain questions concerning the Cantor ternary set. The second chapter deals with proving that the Cantor ternary set is equivalent to the middle thirds set of [0,1], closed, compact, and has Lebesgue measure zero. Further a proof that the Cantor ternary set is a locally compact, Hausdorff topological group is given. The third chapter is concerned with establishing the existence of a Haar integral on certain topological groups. In particular if G is a locally compact and Hausdorff topological group, then there is a non-zero translation invariant positive linear form on G. The fourth chapter deals with proving that for any Haar integral I on G there exists a unique Haar measure on G that represents I.
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Leifsson, Patrik. "Fractal sets and dimensions." Thesis, Linköping University, Department of Mathematics, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7320.
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Fractal analysis is an important tool when we need to study geometrical objects less regular than ordinary ones, e.g. a set with a non-integer dimension value. It has developed intensively over the last 30 years which gives a hint to its young age as a branch within mathematics.
In this thesis we take a look at some basic measure theory needed to introduce certain definitions of fractal dimensions, which can be used to measure a set's fractal degree. Comparisons of these definitions are done and we investigate when they coincide. With these tools different fractals are studied and compared.
A key idea in this thesis has been to sum up different names and definitions referring to similar concepts.
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Stettin, Rebecca A. "Generalizations and Properties of the Ternary Cantor Set and Explorations in Similar Sets." Ashland University Honors Theses / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=auhonors1494171314877262.
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Hyde, James Thomas. "Constructing 2-generated subgroups of the group of homeomorphisms of Cantor space." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/11362.
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We study finite generation, 2-generation and simplicity of subgroups of H[sub]c, the group of homeomorphisms of Cantor space. In Chapter 1 and Chapter 2 we run through foundational concepts and notation. In Chapter 3 we study vigorous subgroups of H[sub]c. A subgroup G of H[sub]c is vigorous if for any non-empty clopen set A with proper non-empty clopen subsets B and C there exists g ∈ G with supp(g) ⊑ A and Bg ⊆ C. It is a corollary of the main theorem of Chapter 3 that all finitely generated simple vigorous subgroups of H[sub]c are in fact 2-generated. We show the family of finitely generated, simple, vigorous subgroups of H[sub]c is closed under several natural constructions. In Chapter 4 we use a generalised notion of word and the tight completion construction from [13] to construct a family of subgroups of H[sub]c which generalise Thompson's group V . We give necessary conditions for these groups to be finitely generated and simple. Of these we show which are vigorous. Finally we give some examples.
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Ehnes, Tim [Verfasser], and Uta Renata [Akademischer Betreuer] Freiberg. "Stochastic partial differential equations on Cantor-like sets / Tim Ehnes ; Betreuer: Uta Renata Freiberg." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2020. http://d-nb.info/1218532289/34.
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Roinestad, Kristine A. "Geometry of Fractal Squares." Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/26883.
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This paper will examine analogues of Cantor sets, called fractal squares, and some of the
geometric ways in which fractal squares raise issues not raised by Cantor sets. Also discussed
will be a technique using directed graphs to prove bilipschitz equivalence of two fractal
squares.Ph. D.
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Wang, Nancy. "Fractal Sets: Dynamical, Dimensional and Topological Properties." Thesis, KTH, Skolan för teknikvetenskap (SCI), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-233147.
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Fractals is a relatively new mathematical topic which received thorough treatment only starting with 1960's. Fractals can be observed everywhere in nature and in day-to-day life. To give a few examples, common fractals are the spiral cactus, the romanesco broccoli, human brain and the outline of the Swedish map. Fractal dimension is a dimension which need not take integer values. In fractal geometry, a fractal dimension is a ratio providing an index of the complexity of fractal pattern with regard to how the local geometry changes with the scale at which it is measured. In recent years, fractal analysis is used increasingly in many areas of engineering and technology. Among others, fractal analysis is used in signal and image compression, computer and video design, neuroscience and fractal based cancer modelling and diagnosing. This study consists of two main parts. The first part of the study aims to understand the appearance of an irregular Cantor set generated by the chaotic dynamical system generated by the logistic function on the unit interval [0,1]. In order to understand this irregular Cantor set, we studied the topological properties of the Cantor Middle-thirds set and the generalised Cantor sets, all of which have zero length. The necessity to compare these sets with regard to their size led us to the second part of this paper, namely the dimension studies of fractals. More complex fractals were presented in the second part, three definitions of dimension were introduced. The fractal dimension of the irregular Cantor set generated by the logistic mapping was estimated and we found that the Hausdorff dimension has the widest scope and greatest flexibility in the fractal studies.Fraktaler är ett relativt nytt ämne inom matematik som fick sitt stora genomslag först efter 60-talet. En fraktal är ett självliknande mönster med struktur i alla skalor. Några vardagliga exempel på fraktaler är spiralkaktus, romanescobroccoli, mänskliga hjärnan, blodkärlen och Sveriges fastlandskust. Bråktalsdimension är en typ av dimension där dimensionsindexet tillåts att anta alla icke-negativa reella tal. Inom fraktalgeometri kan dimensionsindexet betraktas som ett komplexitetsindex av mönstret med avseende på hur den lokala geometrin förändras beroende på vilken skala mönstret betraktas i. Under det senaste decenniet har fraktalanalysen använts alltmer flitigt inom tekniska och vetenskapliga tillämpningar. Bland annat har fraktalanalysen använts i signal- och bildkompression, dator- och videoformgivning, neurovetenskap och fraktalbaserad cancerdiagnos. Denna studie består av två huvuddelar. Den första delen fokuserar på att förstår hur en fraktal kan uppstå i ett kaotiskt dynamiskt system. För att vara mer specifik studerades den logistiska funktionen och hur denna ickelinjära avbildning genererar en oregelbunden Cantormängd på intervalet [0,1]. Vidare, för att förstå den oregelbundna Cantormängden studerades Cantormängden (eng. the Cantor Middle-Thirds set) och de generaliserade Cantormängderna, vilka alla har noll längd. För att kunna jämföra de olika Cantormängderna med avseende på storlek, leds denna studie vidare till dimensionsanalys av fraktaler som är huvudämnet i den andra delen av denna studie. Olika topologiska fraktaler presenterades, tre olika definitioner av dimension introducerades, bland annat lådräkningsdimensionen och Hausdorffdimensionen. Slutligen approximerades dimensionen av den oregelbundna Cantormängden med hjälp av Hausdorffdimensionen. Denna studie demonstrerar att Hausdorffdimensionen har större omfattning och mer flexibilitet för fraktalstudier.
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Yingst, Andrew Q. "A Characterization of Homeomorphic Bernoulli Trial Measures." Thesis, University of North Texas, 2006. https://digital.library.unt.edu/ark:/67531/metadc5331/.
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We give conditions which, given two Bernoulli trial measures, determine whether there exists a homeomorphism of Cantor space which sends one measure to the other, answering a question of Oxtoby. We then provide examples, relating these results to the notions of good and refinable measures on Cantor space.
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Handy, Jonathan Michael. "Bounded analytic functions on the complements of square cantor sets the corona problem and related problems /." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1464114061&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
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Aguiar, Francisco Fagner Portela. "Um background na teoria dos conjuntos." reponame:Repositório Institucional da UFC, 2015. http://www.repositorio.ufc.br/handle/riufc/13985.
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AGUIAR, Francisco Fagner Portela. Um background na teoria dos conjuntos. 2015. 50 f. Dissertação (Mestrado em Matemática em Rede Nacional) – Centro de Ciências, Universidade Federal do Ceará, Fortaleza, 2015.Submitted by Erivan Almeida (eneiro@bol.com.br) on 2015-11-13T15:41:09Z No. of bitstreams: 1 2015_dis_ffpaguiar.pdf: 1566390 bytes, checksum: 114ad96172cfa622234e88e05d73ffff (MD5)
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The set theory sometimes left out in some high schools, is in a key element for understanding the functions in particular. Failure to address this issue or its superficial approach leaves the student a difficult gap to be filled in later studies. Incidentally, the left gap may hinder student performance in higher education. If this is so, is the main objective of this work to a reinterpretation of the main topics linked to the high school set theory, while making a bridge between these and other equally important points dealing with sets in a more academic language. Will be covered from the properties and theorems related to finite sets up its generalization to infinite sets, culminating in the Cantor-Schroeder-Bernstein theorem, the Axiom of Choice and Zorn’s Lemma. To this end, there were literature searches in various sources.
A teoria de conjuntos por vezes deixada de lado em algumas escolas de ensino médio, constitui-se em um elemento primordial para o entendimento das funções, em especial. A não abordagem, ou a sua abordagem superficial, deixa no estudante uma lacuna difícil de ser suprida em estudos posteriores. Aliás, a lacuna deixada pode dificultar o desempenho do estudante no ensino superior. Diante desta constatação, é objetivo principal desta dissertação fazer uma leitura dos principais tópicos ligados à Teoria de Conjuntos do ensino médio, ao mesmo tempo em que faz uma ponte entre estes e outros pontos não menos importantes, tratando conjuntos em uma linguagem mais acadêmica. Serão abordados desde as propriedades e teoremas relacionados a conjuntos finitos, até a sua generalização para conjuntos infinitos, culminando com o teorema de Cantor-Schroeder-Bernstein, o Axioma da Escolha, e o Lema de Zorn. Para tantos, realizaram-se pesquisas bibliográficas em fontes variadas.
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Reid, James Edward. "Numerical Values of the Hausdorff and Packing Measures for Limit Sets of Iterated Function Systems." Thesis, University of North Texas, 2017. https://digital.library.unt.edu/ark:/67531/metadc1011825/.
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In the context of fractal geometry, the natural extension of volume in Euclidean space is given by Hausdorff and packing measures. These measures arise naturally in the context of iterated function systems (IFS). For example, if the IFS is finite and conformal, then the Hausdorff and packing dimensions of the limit sets agree and the corresponding Hausdorff and packing measures are positive and finite. Moreover, the map which takes the IFS to its dimension is continuous. Developing on previous work, we show that the map which takes a finite conformal IFS to the numerical value of its packing measure is continuous. In the context of self-similar sets, we introduce the super separation condition. We then combine this condition with known density theorems to get a better handle on finding balls of maximum density. This allows us to extend the work of others and give exact formulas for the numerical value of packing measure for classes of Cantor sets, Sierpinski N-gons, and Sierpinski simplexes.
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Minorics, Lenon Alexander [Verfasser], and Uta Renata [Akademischer Betreuer] Freiberg. "Spectral asymptotics for Dirichlet Laplacians on random Cantor-like sets and on their complement / Lenon Alexander Minorics ; Betreuer: Uta Renata Freiberg." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2019. http://d-nb.info/1195529406/34.
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Le, Manach Florian. "Sur l’approximation et la complétude des translatés dans les espaces de fonctions." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0237/document.
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Nous nous intéressons à l'étude de la cyclicité et la bicyclicité dans les espaces $ell^p(Z)$ à poids et à l'étude de la cyclicité dans les espaces de Dirichlet. Alors que Wiener a caractérisé la bicyclicité des vecteurs de $ell^1(Z)$ et $ell^2(Z)$ grâce à l'ensemble des zéros de la transformée de Fourier, Lev et Olevski ont démontré que cet ensemble ne peut caractériser la bicyclicité dans $ell^p(Z)$ lorsque $1We are interested in the study of cyclicity and bicyclicity in weighted $ell^p(Z)$ spaces and the study of cyclicity in Dirichlet spaces. While Wiener characterized the bicyclicity in $ell^1(Z)$ and $ell^2(Z)$, thanks to the zero set of the Fourier transform, Lev and Olevski have shown that this set cannot characterize bicyclicity in $ell^p(Z)$ when $1 < p < 2$ for sequences in $ell^1(Z)$. Also Beurling, Salem and Newman were interested in the bicyclicity in $ell^p(Z)$ when $1 < p < 2$. In this work, we first extend the results of Beurling, Salem and Newman to the weighted $ell^p(Z)$ spaces, by studying the Hausdorff dimension and the capacity of the zero set of the Fourier transform. Then we prove that the Lev-Olevskii result remains valid for cyclicity in $ell^p(Z)$, $1 < p < 2$. In addition, we give sufficient conditions for the cyclicity in the weighted $ell^p(Z)$ spaces. Finally, we prove that, for a function $f$ in the disk algebra and in a generalized Dirichlet space, if $f$ is outer and the zero set of $f$ is reduced to a point then $f$ is cyclic. This generalizes the result of Hedenmalm and Shields who have treated the case of the classical Dirichlet space
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Costa, Carolina Lourenço da. "Suplementação com Vitamina D e seus derivados na prevenção e tratamento do cancro da próstata." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/4081.
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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências FarmacêuticasIntrodução: O cancro da próstata é, sem dúvida, o tipo mais comum de cancro entre os Homens em todo o mundo. Apesar da sua etiologia não se encontrar totalmente esclarecida, ambos os fatores, genéticos e ambientais, poderão ter uma influência sobre a doença. Alguns estudos epidemiológicos sugerem que a vitamina D pode ter um efeito preventivo no desenvolvimento do cancro da próstata. Ao longo do presente estudo, realiza-se uma prévia contextualização teórica acerca da vitamina D (as suas formas ativa e circulante) e uma revisão de literatura acerca da sua associação com a prevenção e tratamento do cancro da próstata, seguida de uma revisão sistemática de literatura sobre o papel da vitamina D na prevenção e tratamento do cancro da próstata. Objetivos: Realizar uma revisão sistemática de literatura acerca do papel da vitamina D na prevenção do cancro da próstata. Analisar variáveis que afetam esta associação, nomeadamente a exposição solar (localização geográfica), dieta alimentar, os grupos étnicos (cor da pele) ou a influência do património genético Material/Métodos: Procurou-se rever a literatura existente nas bases de dados informáticas de maior credibilidade científica: iniciou-se com o Cochrane Database of Systematic Reviews, e em seguida, no PubMed “Clinical Queries” e Science Direct, dentro de um período de tempo considerado fiável (1993-2013). A pesquisa centrou-se em artigos redigidos em inglês. Resultados: Os estudos selecionados apresentaram resultados relativos a parâmetros diferentes: 7 estudos avaliaram os níveis séricos da vitamina D, 3 estudos analisaram a influência da exposição solar e 1 estudo a relação da dieta alimentar, com o desenvolvimento do cancro da próstata. Os resultados obtidos expressam-se em cada uma das três grandezas, Odds Ratio (OR), Risco Relativo (RR) e Hazard Ratio (HR), permitindo obter evidências conclusivas. Dos 11 estudos apresentados, encontraram-se evidências favoráveis à relação da vitamina D com o cancro da próstata em apenas 3 estudos (27%). Os restantes 8 estudos (73%) revelam uma insuficiente, inconsistente e, até mesmo, inexistente evidência do papel preventivo da vitamina D, no desenvolvimento do cancro da próstata (OR, HR, e RR > 1). As variáveis em estudo, a exposição solar (localização geográfica), dieta alimentar ou os grupos étnicos (cor da pele) foram analisadas e concluiu-se que os resultados não são consistentes relativamente à localização geográfica e aos grupos étnicos, no entanto não se verificou a influência positiva da alimentação na prevenção deste tipo de cancro. Conclusão: De uma maneira geral, a revisão sistemática não encontrou uma evidência qualitativa que suporte a associação entre a vitamina D e o desenvolvimento do cancro da próstata. Sugerem-se mais e maiores estudos com diferentes populações étnicas, participantes com diferentes localizações geográficas, com informações precisas das dietas alimentares e do património genético, bem como com informações detalhadas sobre as características deste tipo de cancro, no sentido de melhor esclarecer estas evidências. Introduction: Prostate cancer is undoubtedly the most common type of cancer among men worldwide. Although its etiology is not fully understood find both factors, genetic and environmental, may have an influence on the disease. Some epidemiological studies suggest that vitamin D may have a preventative effect on the development of prostate cancer. Throughout this study, carried out on a previous theoretical contextualization of vitamin D (forms active and current) and a review of literature on its association with the prevention and treatment of prostate cancer, followed by a systematic review of literature on the role of vitamin D in the prevention and treatment of prostate cancer. Objectives: Conduct a systematic review of literature on the role of vitamin D in the prevention of prostate cancer. Examine variables that affect this association, including sun exposure (geographic location), diet, ethnic groups (skin colour) or the influence of genetic. Material/Methods: We sought to review the literature on computer databases of scientific credibility: began with the Cochrane Database of Systematic Reviews, and then in PubMed "Clinical Queries" and Science Direct, within a period of time considered reliable (1993-2013). The research focused on articles written in English. Results: The selected studies presented results for different parameters: 7 studies evaluated serum levels of vitamin D, 3 studies examined the influence of sun exposure and one study the relationship of diet, with the development of prostate cancer. The results are expressed in each of the three quantities, odds Ratio (OR), relative risk (RR) and hazard ratio (HR), allowing to obtain conclusive evidence. Of the 11 studies presented, we found evidence supporting the relationship of vitamin D with prostate cancer in only three studies (27%). The remaining eight studies (73%) show an insufficient and inconsistent, even nonexistent, evidence of vitamin D preventive role in the development of prostate cancer (OR, SR and RR> 1). The variables, sun exposure (geographic location), diet or ethnic groups (skin colour) were analyzed and it was concluded that the results are not consistent with regard to geographical location and ethnic groups, however there was no positive influence of food in preventing this type of cancer. Conclusion: In general, the systematic review didn’t found qualitative evidence that supports an association between vitamin D and development of prostate cancer. Suggest more and larger studies with different ethnic populations, participants with different geographical locations, with accurate information of diets and genetic as well as detailed information about the characteristics of this type of cancer, in order to better clarify this evidence.
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Gardner, Jason H. "A novel method for finding small highly discriminant gene sets." Thesis, Texas A&M University, 2003. http://hdl.handle.net/1969.1/1139.
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In a normal microarray classification problem there will be many genes, on the order of thousands, and few samples, on the order of tens. This necessitates a massive feature space reduction before classification can take place. While much time and effort has gone into evaluating and comparing the performance of different classifiers, less thought has been spent on the problem of efficient feature space reduction.
There are in the microarray classification literature several widely used heuristic feature reduction algorithms that will indeed find small feature subsets to classify over. These methods work in a broad sense but we find that they often require too much computation, find overly large gene sets or are not properly generalizable. Therefore, we believe that a systematic study of feature reduction, as it is related to microarray classification, is in order.
In this thesis we review current feature space reduction algorithms and propose a new, mixed model algorithm. This mixed-modified algorithm uses the best aspects of the filter algorithms and the best aspects of the wrapper algorithms to find very small yet highly discriminant gene sets. We also discuss methods to evaluate alternate, ambiguous gene sets. Applying our new mixed model algorithm to several published datasets we find that our new algorithm outperforms current gene finding methods.
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Hamon, Hélène. "Femmes et cancer : de l'errance au sens." Grenoble 2, 2006. http://www.theses.fr/2006GRE29019.
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L'individu touché par le cancer est acculé à penser l'impensable : sa propre mort. Sa vision du monde, des autres et de lui-même se trouve bouleversée au moment même de l'annonce de la maladie grave. Néanmoins, les individus malades refusent le plus souvent ce chaos engendré par l'annonce du cancer dans leur vie. Pour que celle-ci reste possible et supportable, pour que les malades puissent continuer à affronter leur existence, ils vont devoir produire le sens de leur maladie. A l'issue de ce travail de recherche, nous observons combien, pour ces femmes rencontrées, la possibilité de reconstruction du monde vécu passe par la mise en récit. C'est la nomination des origines de la maladie qui aide à la reconstruction du monde vécu, via la symbolisation de la maladie et de ses conséquences. Cette mise en récit permet à la personne de situer l'évènement de la maladie et la souffrance dans une histoire, elle permet de classer les évènements de sa biographie dans un ordre temporel significatif où est inclus le temps du cancer. Le travail de ces femmes est celui d'une intégration : il s'agit de faire sien un évènement qui en apparence seulement s'abat de l'extérieur, tel un accident. Le corps, les organes touchés par le cancer, la maladie sont ainsi matière de symboles, et c'est également à cette dimension du corps que s'adressent les soignants, malgré eux le plus souvent, sans en avoir pleinement conscience. Ainsi nous nous demandons dans ce travail de recherche dans quelle mesure le vécu des patientes ici analysé et la vie à l'hôpital se rejoignent-t-ils ? La culture des femmes atteintes par un cancer gynécologique et la "culture hospitalière" se rencontrent-elles ?The individual hit by a cancer is forced into thinking of the unthinkable : his own death. At the very moment when the serious illness is announced, his vision of the world, of others and himself gets shattered. Nevertheless most of the time ill persons refuse the chaos induced by the arrival of cancer in their life. But in order to keep that life bearable and the will to fight for existence, patients will have to produce the meaning of their illness. In the end, among the women we met for this research work, we observe that a reconstruction of the actual world is only possible through the setting of a narration. The process of naming the origins of the illness helps to the reconstruction of the actual world by way of a symbolization of the illness and of its consequences. This setting of a narration allows the individual to situate the advent of the illness and sufferings inside a story. Thus the events of his biography are classified in a meaningful temporal order including the time of cancer. What these women have to do is a work of integration: the point is to make that event a part of their own self, although it seems to hit from the outside, like an accident. Then the body, the ill organs and the illness itself are a ground for symbols. The nursing staff also appeal to that dimension of the body, most of the time in spite of themselves, without fully realizing it. That way, in this research work we do wonder to what extent the patients actual experience is linked together with hospital life. Does the culture of women hit by gynaecological cancer ever meet "hospital culture" ?
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Andrade, Klesia Garcia. "Projeto “Um Canto em Cada Canto”: o coro infantil, seus ensinos e suas aprendizagens." Universidade Federal da Paraíba, 2015. http://tede.biblioteca.ufpb.br:8080/handle/tede/8424.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
Nowadays, the choir practices have been established as an important music teaching method. These practices are accessible activities which provide the exploration and experience of music content through the use of the voice. Among the various vocal music initiatives in the educational context in Brazil, we highlight the non-profit sector projects, aiming not only the musical development, but also the development of human rights, the access to cultural and material resources as well as the search for social justice. In this context, we search to understand the teaching and learning processes of music, interwoven to the practice of children's choir, specifically contemplating the Project “Educação Musical Através do Canto Coral – um canto em cada canto” (UCCC Project), located in the city of Londrina-PR. In order to reflect and analyse the musical phenomena in the universe of this Project, this essay’s presents results of a research that had as goal to understand concepts, contents and teaching and learning methodologies that characterize the music formation in the UCCC Project, taking in consideration the socio-cultural particularities from the perspective of the subjects involved in this educational proposal. The theoretical framework is linked to the socio-cultural perspective of music education whose teaching and learning processes are understood in its context, space where they are built and put into practice. From the qualitative approach and the completion of an ethnography, we organized the methodological approach that covers the bibliographic and documentary research, participant observation, semi-structured interviews, focus groups and questionnaire. The analysis of the material takes into account the contextualization of the speech with the symbolic universe that permeates the actions of the participants involved in the Project, as well as the values and meanings that express their relationships with the educational activities and the artistic practice developed. The research results, with relation to concepts, show a focused educational approach to human development and the expansion of the musical and cultural universe of the participants. The contents relate to the repertoire, and some criteria guide their choice. As for the methodology used, the research revealed a proposal based on playful learning made possible through orality, imitation, repetition and thinking, in which the educator's role in the teaching of these procedures is of paramount importance for the success of the proposal. While not generalizable, the research results contribute to the unveiling of processes of the teaching and learning of music, favoring important discussions about how this teaching is established through cultural understanding and meanings related to musical practice of a particular group.
As práticas corais têm se constituído, na atualidade, como uma importante modalidade de ensino da música, apresentando-se como uma atividade acessível e proporcionando, a partir do uso da voz, a exploração e vivência de conteúdos musicais. No Brasil, entre as diversas iniciativas de canto coral no contexto educativo, destacam-se projetos do Terceiro Setor com propostas que objetivam, além do desenvolvimento musical, a valorização dos direitos humanos, o acesso aos bens materiais e culturais, bem como a busca por justiça social. Nesse contexto, foram investigados processos de ensino de aprendizagem da música imbricados à prática de coro infantil, contemplando especificamente o Projeto “Educação Musical Através do Canto Coral – um canto em cada canto” (Projeto UCCC), situado na cidade de Londrina- PR. Com vistas a refletir e analisar os fenômenos musicais no universo desse Projeto, esta dissertação apresenta resultados de uma pesquisa que teve como objetivo compreender concepções, conteúdos e metodologias de ensino e de aprendizagem que caracterizam a formação musical no Projeto UCCC, considerando as particularidades socioculturais e partindo do olhar dos sujeitos envolvidos na proposta educativa. O referencial teórico articulase com a perspectiva sociocultural da educação musical cujos processos de ensino e aprendizagem são compreendidos no seu contexto, espaço onde são construídos e colocados em prática. A partir da abordagem qualitativa e da realização de uma etnografia, organizamos o percurso metodológico que abrange a pesquisa bibliográfica e documental, observação participante, entrevistas semiestruturadas, grupos focais e aplicação de questionário. A análise do material considera a contextualização da fala com o universo simbólico que permeia a atuação dos personagens do Projeto, bem como os valores e significados que expressam as suas relações com a ação educativa e a prática artística desenvolvida. Os resultados da pesquisa, com relação às concepções, evidenciam uma proposta educativa voltada para a formação humana e a ampliação do universo musical e cultural dos participantes. Os conteúdos trabalhados relacionam-se com o repertório, sendo que alguns critérios norteiam a sua escolha. Quanto à metodologia empregada, a pesquisa revelou uma proposta fundamentada em procedimentos lúdicos viabilizados por meio da oralidade, imitação, repetição e reflexão, no qual o papel do educador na condução desses procedimentos apresenta-se essencial para o sucesso da proposta. Mesmo não sendo generalizáveis, os resultados da pesquisa contribuem no desvelamento dos processos de ensino e aprendizagem da música, favorecendo importantes discussões sobre como este ensino se estabelece mediante a compreensão cultural e dos significados relativos a prática musical de um determinado grupo.
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Castanho, Maria Jose de Paula. "Construção e avaliação de um modelo matematico para predizer a evolução do cancer de prostata e descrever seu crescimento utilizando a teoria dos conjuntos fuzzy." [s.n.], 2005. http://repositorio.unicamp.br/jspui/handle/REPOSIP/260504.
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Orientadores: Akebo Yamakami, Laecio Carvalho de Barros, Laercio Luis VenditeTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Eletrica e de Computação
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Resumo: O câncer de próstata é, atualmente, o segundo tipo de câncer com maior incidência entre a população masculina, no Brasil. Estimar o seu estágio, com as informações clínicas disponíveis para decidir a terapia a ser aplicada, é uma tarefa árdua. Neste trabalho, um modelo matemático é elaborado para auxiliar o médico na tomada de decisão. A teoria dos conjuntosfuzzy, por sua capacidade em lidar com incertezas, inerentes aos conceitos médicos, é a ferramenta utilizada, não só para desenvolver o modelo, como também para desenvolver a metodologia para sua avaliação, baseada na análise ROC (Receiver Operating Characteristic). A avaliação foi feita utilizando-se dados obtidos junto ao Instituto Americano do Câncer e permite afinnar que o sistema especialista construí do discrimina pacientes com câncer confinado à próstata daqueles com câncer não-confinado. Considerando a taxa de crescimento como um parâmetro incerto e variável na população, também é apresentado um modelo para descrever o crescimento do tumor
Abstract: Nowadays, prostate cancer is the second most common man cancer diagnosed in Brazil. Predicting the cancer stage from available clinical information to decide the therapy to be used is hard work. ln this study a mathematical model is developed to assist the physician in this task. The fuzzy sets theory provides effective tools to handle and manipulate imprecise data and to make decisions based on such data. As imprecision is a characteristic of medical concepts, this theory is utilized not oniy to develop the model as to develop the methodology for its evaluation, based on ROC (Receiver Operating Characteristic) analysis. To evaluate its performance, data from the American Cancer lnstitute were used. The results indicate that the model is able to discriminate patients with organ-confined disease from those with non-confined cancer. In addition, considering the growth rate as an uncertain, changeable parameter in the population, a model to describe the tumor growth is suggested.
Doutorado
Automação
Doutor em Engenharia Elétrica
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Benzina, Sami. "Combinaison entre des sels de platine et des radiations à transfert linéique d'énergie élevé : Etude des conséquences cytotoxiques et des mécanismes sous-tendant la mort cellulaire." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. http://www.theses.fr/2007STR13181.
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L’étude des mécanismes conduisant à la mort cellulaire suscite un intérêt croissant dans l’élaboration de nouvelles thérapeutiques du cancer car elle conditionne leur action. D’autre part, les combinaisons entre les radiations à transfert linéique d’énergie (TLE) faible utilisées en radiothérapie conventionnelle et certaines drogues utilisées en chimiothérapie ont fait preuve d’une grande efficacité. En particulier, les associations entre les radiations et les sels de platine ont fait l’objet d’un nombre important de travaux de recherche. En revanche, les combinaisons entre les radiations à TLE élevé (radiations particulaires qui provoquent plus de dommages cellulaires particulièrement au niveau de l’ADN) et la chimiothérapie ont rarement été étudiées jusqu’ici, et ce en dépit de leur intérêt dans la définition de protocoles combinant la chimiothérapie et l’hadronthérapie (qui met en oeuvre des particules à TLE élevé). Ceci a motivé notre démarche consistant à combiner des neutrons rapides (radiations à TLE élevé) et des sels de platine utilisés en chimiothérapie, afin de déterminer les éventuels avantages qui peuvent être obtenus, ainsi que les mécanismes de mort cellulaires impliqués dans ces effets. Dans un premier temps, mon travail a consisté à étudier les conséquences, sur la survie de cellules lymphocytaires en culture, d’associations entre une irradiation par des neutrons rapides, produits au cyclotron de Louvain-la-Neuve, et le cisplatine (CP). Nos résultats, obtenus avec la lignée lymphoïde murine RDM4, ont montré que l’association entre des neutrons rapides et le CP provoquait un accroissement de l’apoptose. Cependant, l’apoptose n’est pas l’unique responsable de cette cytotoxicité, puisque la sénescence prématurée y contribue de manière équivalente. Nous avons ensuite sélectionné la lignée U-87, issue d’un glioblastome humain et connue pour sa radiorésistance. Avec ces cellules, j’ai confirmé que le CP provoquait une potentialisation importante de l’effet des neutrons rapides, qui fait intervenir les deux types de mort cellulaire précités. Dans une troisième étape de ce travail, j’ai introduit un autre sel de platine, dit de « troisième génération » : l’oxaliplatine (OX), utilisé principalement pour le traitement de cancers colorectaux. La combinaison entre les neutrons rapides et l’OX provoque une forte diminution de la survie clonogénique. Mais, contrairement au CP, il n’y a pas augmentation de l’apoptose. En revanche, les cellules cotraitées par l’OX et les neutrons rapides ont un cycle anormal. Il y a inhibition du passage à la phase S provoquée par une surexpression de p21 et p53. Une autre approche a consisté à déterminer si l’oxaliplatine amplifiait le nombre de coupures double brin d’ADN induites par les neutrons rapides. Dans ces expériences, j’ai utilisé un anticorps reconnaissant la forme phosphorylée d’H2AX, une histone qui, après activation, intervient dans la réparation de ces cassures très dangereuses pour la cellule. Les résultats indiquent que ces coupures dans l’ADN sont plus abondantes après cotraitement, et que la cytotoxicité de l’association oxaliplatine + neutrons rapides pourrait donc être liée à ces dommages difficilement réparables. Enfin, l’efficacité d’un traitement combinant l’oxaliplatine aux neutrons rapides a été évaluée in vivo, sur des souris porteuses de tumeurs U-87. Les souris recevaient, deux heures avant d’être irradiées à 4 Gy, une injection d’OX. Trente jours après l’irradiation, elles étaient sacrifiées et le volume et le poids des tumeurs étaient mesurés. Chez les souris co-traitées, l’évolution tumorale a été fortement réduite puisque ces animaux ont développé des tumeurs quatre fois plus petites que les souris contrôles et trois fois moins grosses que celles seulement irradiées. Ces résultats soulignent l’intérêt d’un tel cotraitement et ouvrent des perspectives d’application en hadronthérapie
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Velho, Homero Antonio Strini. "O curso de canto da UNESP : o impacto do ensino superior no discurso dos seus egressos /." São Paulo, 2019. http://hdl.handle.net/11449/181312.
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Orientador: Adriana Giarola KayamaBanca: Abel Rocha
Banca: Luiz Ricardo Ballestero
Banca: Wladimir Farto Contesini de Mattos
Resumo: Esta tese de doutorado investiga como os egressos do curso de bacharelado em música-habilidade canto da UNESP avaliam sua educação universitária e o impacto que eles acreditam que essa sobre suas trajetórias profissionais. Esta tese encontra respaldo no crescente interesse de IES nos estudos de egressos como método de avaliação institucional. Através de uma abordagem metodológica mista (quantitativa e qualitativa) foi possível traçar as trajetórias musicais e profissionais dos egressos do curso de canto desde o período pré-universitário, passando pelos anos de graduação e escolhas profissionais após a conclusão do curso. A análise dos dados coletados utilizou-se da teoria de campos do sociólogo francês Pierre Bourdieu, que serviu tanto para delimitar um "campo vocal" dentro das atividades profissionais existentes na grande área de música, quanto para explicar como a universidade, pertencente ao campo acadêmico, ignora as especificidades inerentes à área da música, pertencente ao campo da produção artística. O enfraquecimento dos conservatórios e a derrocada do ensino musical na educação básica brasileira transformaram o curso superior em música em uma versão reestruturada do modelo conservatorial. Os resultados nos mostram que a maior parte dos egressos investigados buscavam na UNESP uma formação musical institucional estruturada. Embora o curso de canto tenha sofrido críticas específicas relativas ao seu funcionamento, a maior parte dos egressos consegue se manter economicam... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: This doctoral dissertation investigates how alumni from the Bachelor of Music - voice - degree from UNESP evaluate the impact tertiary education had on their professional careers. This thesis is justified by the growing interest that HEIs attribute to alumni studies as a method of institutional evaluation. Using mixed methods of investigation (quantitative and qualitative) it was possible to trace alumni's professional and musical paths beginning from their pre-university years, continuing through their university education and professional choices after graduation. Pierre Bourdieu's theory of social fields was used to interpret collected data and was used in delimiting a "vocal field" within the professional activities within music as a general area, as well as an explanation of how the university, which belongs to the academic field, ignores the inherent specificities of music, which belongs to the field of artistic production. The weakening of conservatories and the collapse of music education in Brazilian primary education have restructured tertiary music education into functioning as version of the conservatory model. The results show that most of the alumni look for an institutionally structured music degree that will tend to basic music training and understanding. Although the voice program was criticized because of operational flaws most of its alumni have been active in the music field, even though not all were able to position themselves professionally as they had e... (Complete abstract click electronic access below)
Doutor
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Narayanan, Sreeram. "Rapid 3d seed reconstruction from incomplete data sets for image guided prostate brachytherapy /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/5825.
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Castro, Tialfi Bergamin de. "A melatonina e seus metabólitos como marcadores prognósticos em neoplasias mamárias humanas." Universidade Estadual Paulista (UNESP), 2017. http://hdl.handle.net/11449/152220.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O câncer de mama é a principal causa de mortes relacionadas ao câncer em mulheres e pesquisas têm sido focadas em identificar e validar biomarcadores que podem ser utilizados para confirmar o diagnóstico e determinar o prognóstico. Mudanças no ritmo circadiano podem contribuir para o desenvolvimento do câncer e sendo assim, a melatonina, um hormônio sintetizado pela glândula pineal à noite, na ausência de luz e seus metabolitos AFMK e AMK são sugeridos como potenciais biomarcadores. A melatonina pode atuar através do receptor MT1 regulando cinases e a expressão de genes específicos relacionados a proliferação, angiogênese, diferenciação celular e transporte de glicose. A expressão elevada de GLUT1 (Glucose Transporter-1) está associada ao prognóstico ruim no câncer. Os objetivos deste estudo foram comparar os níveis de melatonina, AFMK e AMK em mulheres recentemente diagnosticadas com câncer de mama, mulheres em quimioterapia adjuvante, enfermeiras que trabalham à noite em comparação com mulheres saudáveis e hábitos normais e avaliou-se a expressão do receptor MT1 e GLUT1 em tumores de mama e correlacionou com os subtipos moleculares, características patológicas e prognóstico. Foi coletado sangue de 53 mulheres com câncer de mama sendo 47 sem tratamento e 6 em quimioterapia adjuvante, 19 mulheres saudáveis sendo 1 O enfermeiras de turno noturno e 9 mulheres de hábitos normais. Os compostos foram quantificados por espectrometria de massas. Para a expressão de MT1 e GLUT1 foi realizada imunohistoquímica em 42 tumores de mama. Os resultados mostraram que mulheres com câncer de mama tiveram níveis menores de melatonina em comparação com mulheres de hábitos normais (p< 0.01 ), níveis ainda mais baixos em enfermeiras que trabalham no período noturno e em pacientes em quimioterapia adjuvante (p<0.01). Não houve diferença significativa nos níveis de AFMK e AMK entre os grupos (p>0.05). Além disso, pacientes com metástase apresentaram níveis elevados de melatonina e AFMK (p=0.02 e p=0.01, respectivamente) e altos níveis de AFMK estavam presentes quando linfonodos estavam acometidos (p=0.04), pacientes com tumores maiores que 20mm e que dormem com luz à noite (p=0.02 e p=0.007, respectivamente). Na análise imunohistoquímica, alta expressão do MT1 foi associada ao subtipo Luminal A, melhor prognóstico (p<0.05) e em tumores RE+ (p=0.002), enquanto que a expressão elevada de GLUT1 foi associada ao triplonegativo, pior prognóstico (p<0.05), tumores maiores que 20mm 9p=0.004) e baixa em tumores RE+ (p=0.003). Em conclusão, nossos resultados mostram menores níveis de melatonina em pacientes com câncer de mama e apontam para o benefício da suplementação de melatonina como proteção para mulheres que trabalham à noite o que poderia reduzir o risco de desenvolvimento de câncer de mama. Os resultados da imunohistoquímica indicam que o MT1 e o GLUT1 podem ser utilizados como marcadores prognósticos e são potenciais alvos para o tratamento do câncer de mama. De acordo com os resultados podese concluir que a quebra do ciclo circadiano e, portanto, alterações nos níveis de melatonina e a expressão de MT1 e GLUT1 podem estar relacionadas com o risco de desenvolvimento e prognóstico do câncer de mama.
Breast cancer is the Jeading cause of cancer-related deaths in women and researches has been focused on identify and validate biomarkers that can be used to confirm the diagnosis and determine the prognosis. Changes in circadian rhythm may contribute to the development of cancer and thus melatonin, a hormone synthesized by the pineal gland at night, in the absence of light and its metabolites AFMK and AMK are suggested as potential biomarkers. Melatonin can act through the MT1 receptor by regulating kinases and the expression of specific genes related to proliferation, angiogenesis, ce/1 differentiation and glucose transport. High GLUT1 (Glucose Transporter-1) expression is associated with poor prognosis in cancer. The objectives of this study were to compare the leveis of melatonin, AFMK and AMK in women newly diagnosed with breast cancer, women on adjuvant chemotherapy, health nurses which work at night compared to healthy women and normal habits and the expression of MT1 receptor and GLUT1 in breast tumors and correlated with molecular subtypes, pathological features and prognosis. Blood from 53 women with breast cancer was colletcted, 47 of them without treatment and 6 in adjuvant chemotherapy, 19 healthy women, 1 O of them night shift nurses and 9 women of normal habits. Compounds were quantified by mass spectrometry. For the expression of MT1 and GLUT1, immunohistochemistry was performed in 42 breast tumors. The results showed that women with breast cancer had lower leveis of melatonin compared to normal women (p <0.01), even Jower leveis in nurses working at night and in adjuvant chemotherapy (p <0.01). There was no significant difference in AFMK and AMK leveis between groups (p> 0.05). ln addition, patients with metastasis had high leveis of melatonin and AFMK (p = 0.02 and p = 0.01, respectively) and high leveis of AFMK were present when lymph nades were affected (p = 0.04), patients with tumors larger than 20mm and who sleep with light at night (p = 0.02 and p = 0.007, respectively). ln the immunohistochemical analysis, high MT1 expression was associated with the Luminal A subtype, with a better prognosis (p
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MICELI, ANA VALÉRIA PARANHOS. "CHILDHOOD AND JUVENILE CANCER: SIBLINGS, THE CHILDREN NO ONE SEES." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2013. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=34381@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIROEste trabalho vem refletir sobre as repercussões do câncer infanto-juvenil nos irmãos das crianças doentes. O câncer é apresentado como doença grave que abala a estrutura familiar afetando a todos os membros da família. Como no imaginário social o câncer é sempre associado à morte, a família reproduz a conspiração do silêncio em torno da morte, impedindo a livre circulação das informações sobre a doença e os tratamentos, deixando as crianças entregues às suas próprias fantasias sobre o adoecimento e o tratamento do irmão. Em virtude de longos períodos de hospitalização para acompanhamento do filho doente, os pais, sobretudo a mãe, marcam os demais filhos com sua ausência e demandam mudanças importantes na rotina familiar e uma equivocada exigência de súbita maturidade. Realizamos pesquisa de campo qualitativa com sete irmãos, com idades variando entre 8 e 16 anos, utilizando entrevistas semiestruturadas cujos conteúdos foram analisados em quatro categorias: representações sobre a doença e a morte; sobre afetos relacionados ao irmão doente; sobre perdas; e sobre ambiente e mudanças. Os resultados apontam para sentimentos também observados em outras pesquisas (tristeza, solidão, rejeição, ciúmes, raiva, culpa, ressentimento; insatisfação com a informação recebida; medo da morte; sentimentos de perda e de abandono; queixa da ausência física e emocional dos pais; rivalidade entre os irmãos; ruptura da normalidade e da segurança dentro da família; mudanças nos papéis e relacionamentos familiares; diminuição da vida social ou isolamento social; dificuldades escolares; empobrecimento da qualidade de vida; queixas somáticas ou preocupação com a própria saúde; sentimentos de compaixão, de amadurecimento, de maior responsabilidade, de independência; percepção, compromisso ou desejo de maior coesão familiar) e, ainda, para a vergonha, a inveja, o altruismo, o heroismo e a expectativa que as crianças têm de verem seus esforços reconhecidos. Interpretamos e discutimos os resultados à luz da psicanálise e concluimos que o câncer irrompe com força traumática na família não só pelas particularidades da doença e sua associação à morte, mas, sobretudo, pela sensação de desamparo e exclusão vivenciada pelos irmãos ditos saudáveis . A doença e os desdobramentos que ela provoca trazem algo inesperado e incompreensível para a criança que se encontrava despreparada para o evento e ainda não era capaz de uma reação madura ao mesmo. Esta falha ambiental, uma falha no cuidado, pode ser vivenciada como traumática, com efeitos em curto, médio ou longo prazo, demandando maior atenção e cuidado para com estes irmãos. Entretanto, eles não recebem o devido suporte familiar, nem social, nem escolar, nem da equipe de saúde, pois são as crianças que ninguém vê.
This paper contemplates the repercussions of childhood and juvenile cancer on the patients siblings. Cancer is presented as a serious illness that threatens the family s structure affecting all of its members. Since cancer is always related to death in social imagination, the family reproduces the silent conspiracy around the theme, creating obstacles to the free circulation of information about the disease and its treatment, leaving children subject to their own fantasies about the illness and treatment of their sibling. The parents, specially the mother, are frequently absent due to prolonged hospitalizations, affecting the other children who suffer important changes in their routine and are equivocally demanded to mature more rapidly. Qualitative field research was done with seven siblings, ages between 8 and 16, using semi-structured interviews whose content was analyzed in four categories: representations about illness and death; about emotions concerning the sick brother/sister; about loss and about the environment and its changes. The results point towards feelings also observed in other studies (sadness, loneliness, rejection, jealousy, rage, guilt, resentment, dissatisfaction with the information received, fear of death, feelings of loss and abandonment, complaints about the physical and emotional absence of parents, rivalry with other siblings, rupture in normality and safety in the family, changes in roles and family relationships; diminution of social life and even social isolation; scholastic difficulties; impoverishment of life’s quality; somatic complaints and preoccupation with one s own health; feelings of compassion; of maturity, of more responsibility, and of independence; increased perceptiveness and commitment; desire of more family cohesion) and also to shame, envy, altruism, heroism, and the kids expectation of having their own efforts recognized. We have interpreted and discussed the results in the light of psychoanalytic viewpoints and concluded that cancer disrupts the family with traumatic force not only due to its characteristics and association with death, but moreover, due to the sensation of helplessness and the exclusion felt by the healthy siblings. The disease and its developments bring out something incomprehensible to the child that was unprepared for the event and still was not capable of a mature reaction to the fact. This environmental failure, a flaw in the caring of the child can be lived as traumatic with short, medium and long term effects, demanding more attention and care of these siblings. However, they get neither familiar, social, scholastic or support of the health team, because these are the children no one sees.
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Johnston, Hannah Elizabeth. "Systems redox biology analysis of cancer." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31348.
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The Warburg effect describes the survival advantage of cancer cells in that they can proliferate under low oxygen/hypoxic conditions via a less efficient pathway known as glycolysis. It has not yet been documented at which point, in an oxygen gradient, phenotypic changes occur. Measuring the intracellular redox potential (IRP) and its impact on cellular dynamics would provide greater insight into how disruption of redox homeostasis caused by changes in oxygen concentration leads to aberrant cell signalling and diseases such as cancer. Current techniques in measuring IRP include redox-sensitive fluorescent proteins such as roGFP which is glutathione-specific. Measuring the concentration of one redox couple is, however, not an accurate representation of IRP as it does not necessarily inform about the state of other redox couples. Furthermore, fluorescent biosensors can suffer from photobleaching and may interact with other oxidants. The IRP was measured, in this work, using our newly developed novel-class of surface enhanced Raman scattering nanoparticles which can quantitatively measure the redox potential of cells in vitro. A 'homemade' device was created to keep the cells under fixed pO2 whilst obtaining measurements. The IRP was correlated with the transcriptomic and downstream metabolic profiles of MCF7 breast cancer cells, under perturbed pO2, using 1H NMR spectroscopy (NMR), mass spectrometry (MS) and RNA-sequencing. Discriminatory metabolites were all associated with energy and glucose metabolism. Discriminatory microRNAs were all affiliated with the hallmarks of cancer; the regulation of some is controlled by transcription factors containing redox-sensitive motifs in their DNA binding domains. Multivariate analysis techniques were used to analyse the different data streams in a holistic way that allows the correlation of redox potential, metabolism and transcription.
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Naqvi, Shabbar. "Modelling FTIR spectral sata with Type-I and Type-II fuzzy sets for breast cancer grading." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/14321/.
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Breast cancer is one of the most frequently occurring cancers amongst women throughout the world. After the diagnosis of the disease, monitoring its progression is important in predicting the chances of long term survival of patients. The Nottingham Prognostic Index (NPI) is one of the most common indices used to categorise the patients into different groups depending upon the severity of the disease. One of the key factors of this index is cancer grade which is determined by pathologists who examine cell samples under a microscope. This manual method has a higher chance of false classification and may lead to incorrect treatment of patients. There is a need to develop automated methods that employ advanced computational methods to help pathologists in making a decision regarding the classification of breast cancer grade. Fourier transform infra-red spectroscopy (FTIR) is one of the relatively new techniques that has been used for diagnosis of various cancer types with advanced computational methods in the literature. In this thesis we examine the use of advanced fuzzy methods with the FTIR spectral data sets to develop a model prototype that can help clinicians with breast cancer grading. Initial work is focussed on using the commonly used clustering algorithms k-means and fuzzy c-means with principal component analysis on different cancer spectral data sets to explore the complexities within them. After that, a novel model based on Type-II fuzzy logic is developed for use on a complex breast cancer FTIR spectral data set that can help clinicians classify breast cancer grades. The data set used for the purpose consists of multiple cases of each grade. We consider two types of uncertainty, one within the spectra of a single case of a grade (intra -case) and other when comparing it with other cases of same grade (inter-case). Features have been extracted in terms of interval data from various peaks and troughs. The interval data from the features has been used to create Type-I fuzzy sets for each case. After that the Type-I fuzzy sets are combined to create zSlices based General Type-II fuzzy sets for each feature for each grade. The created benchmark fuzzy sets are then used as prototypes for classification of unseen spectral data. Type-I fuzzy sets are created for unseen spectral data and then compared against the benchmark prototype Type-II fuzzy sets for each grade using a similarity measure. The best match based on the calculated similarity scores is assigned as the resultant grade. The novel model is tested on an independent spectral data set of oral cancer patients. Results indicate that the model was able to successfully construct prototype fuzzy sets for the data set, and provide in-depth information regarding the complexities of the data set as well as helping in classification of the data.
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Gomes, Joana Cristina Vieira. "Inteligência emocional, qualidade de vida e seus correlatos em doentes oncológicos em quimioterapia." Master's thesis, [s.n.], 2011. http://hdl.handle.net/10284/2969.
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Dissertação apresentada à Universidade Fernando Pessoa, como parte dos requisitos para a obtenção do grau de Mestre em Psicologia, especialização em Psicologia Clínica e da Saúde.O presente estudo tem como objectivos caracterizar a inteligência emocional (IE), qualidade de vida (QDV), ansiedade, depressão e distress emocional de indivíduos com doença oncológica, em quimioterapia; explorar a relação entre a sua IE/QDV e características sócio-demográficas e clínicas e ansiedade, depressão e distress emocional: e, por último, explorar a relação entre a IE e a QDV dos participantes Tendo em vista os objectivos traçados, optou-se por um estudo transversal. Os 60 participantes do estudo, com diferentes neoplasias, são seguidos no Hospital de Dia do Hospital Santo António - Centro Hospitalar do Porto (31 do sexo feminino e 29 do sexo masculino), com idades compreendidas entre os 20 e os 89 anos de idade (M= 57,5; DP= 16,01), responderam a um Questionário sócio-demográfico e clínico, ao Questionário de Competência Emocional, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30, Escala de Ansiedade e Depressão Hospitalar e Termómetro das Emoções. Os resultados obtidos indicam níveis elevados de IE (na escala total e nas três subescalas); níveis satisfatórios no Estado Geral de Saúde/QDV, Funções Física, Cognitiva, Social, Emocional e Desempenho de Papel, com predomínio de Fadiga e Insónia (Escalas dos Sintomas); e baixos níveis de ansiedade, depressão e distress emocional. Não foram observadas relações estatisticamente significativas entre a IE e as características sócio-demográficas e clínicas estudadas. Verificaram-se correlações estatisticamente significativas entre a IE e a ansiedade e a depressão. Identificaram-se relações estatisticamente significativas entre a QDV dos participantes e variáveis sócio-demográficas: nas variáveis sexo, habilitações literárias, situação profissional e agregado familiar. No entanto, não foram registadas relações estatisticamente significativas entre a QDV e as variáveis clínicas analisadas. Obtiveram-se correlações estatisticamente significativas entre a QDV e a ansiedade, a depressão e o distress emocional. Não se verificou uma correlação estatisticamente significativa entre IE e o Estado Geral de Saúde/QDV, excepto entre a subescala da percepção emocional, Funcionamento Cognitivo e Dispneia. Apesar das limitações do estudo, os presentes resultados têm claras implicações para a optimização dos cuidados prestados a indivíduos com doença oncológica em quimioterapia. The aims of the present study were: to characterize the emotional intelligence (EI), quality of life (QOL), anxiety, depression and emotional distress of cancer patients who were receiving chemotherapy; to explore the relationship between their EI/QOL and socio-demographic and clinical characteristics, anxiety, depression and emotional distress; and to explore the relationship between their EI and QOL. Considering these aims, a cross sectional study was designed. Sixty patients with different cancer types, followed up in the Hospital de Dia - Hospital Santo António, Centro Hospitalar do Porto (31 female and 29 male, between 20 and 89 years old (M=57,5; SD=16,01), answered to a socio-demographic and clinical questionnaire, the Emotional Skills and Competence Questionnaire (ESCQ), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30-V.3), Hospital Anxiety and Depression Scale (HADS) and Emotional Thermometer. Results indicate high levels of EI (total and subscales’ scores); satisfactory levels of Global Health Status/QOL, Physical, Cognitive, Social, Emotional, and Role Functions, mostly Fatigue and Insomnia (Symptom Scales); and low levels of anxiety, depression and emotional distress. There were no statistically significant relations between EI and the socio-demographic and clinical characteristics studied. EI correlated with anxiety and depression. Statistically significant relations were found between patients QOL and sociodemographic variables: gender variable, literary skills, professional situation and family constitution. However, there were no statistically significant relations between QOL and the analyzed clinical variables. QOL correlated with depression, anxiety, and emotional distress. EI did not correlate with Global Health Status/QOL, except between the subscale of emotional perception, cognitive functioning and dyspnea. Even though the study has limitations, its results have clear implications for the optimization of care to cancer patients under chemotherapy.
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Jamieson, Lauren Elizabeth. "Measuring redox potential in 3D breast cancer tumour models using SERS nanosensors." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25964.
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Cellular redox potential is incredibly important for the control and regulation of a vast number of processes occurring in cells. Disruption of the fine redox balance within cells is has been associated with disease. Of particular interest to my research is the redox gradient that develops in cancer tumours, in which the internal regions are further from vascular blood supply and therefore become starved of oxygen and hypoxic. This makes treatment of these areas a lot more challenging, as radiotherapy approaches rely on the presence of oxygen and, with a poor vascular blood supply, drugs delivered through the blood stream will have poor access to these regions. Currently, there is limited knowledge regarding the quantitative nature of this redox gradient in cancerous tumours. To aid the development of drugs and therapies to overcome this problem, a system that enables quantitative mapping of redox potential through a tumour would be a vital tool. In this work redox sensitive molecules attached to gold nanoparticles (NPs) are delivered to cells and give signals using surface enhanced Raman scattering (SERS). Redox potential changes are monitored quantitatively by ratiometric changes in signal intensity of selected signals in the SER spectra acquired. Multicellular tumour spheroids (MTS) are used as a three dimensional (3D) in vitro tumour model, in which the 3D architecture and gradients observed in tumours in vivo develop. As redox potential is pH dependent and pH is another important physiological characteristic in its own right, a SERS pH sensor was developed and ultimately a system that multiplexes intracellular pH and redox measurement by SERS. Initially, simultaneous redox potential and pH measurements were performed in monolayer culture before extending this to MTS. Photothermal optical coherence tomography (OCT) was used to investigate overall 3D NP distribution in the MTS models. It was possible to control NP delivery to MTS to localise NPs to various regions. Redox potential and pH could then be measured using a fibre optic Raman probe, and spatial response to drug treatment monitored. Intracellular NP localisation was investigated using transmission electron microscopy (TEM), scanning electron microscopy (SEM), helium ion microscopy (HIM) and confocal fluorescence microscopy (CFM) and attempts were made to control NP delivery to particular intracellular compartments.
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Mallet, Jeremie. "Le cancer chez l’enfant : du phénomène corporel à sa subjectivation." Thesis, Rennes 2, 2019. http://www.theses.fr/2019REN20013.
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Lorsque la pathologie cancéreuse touche l’enfant, figure sacrée du XXIe siècle, c’est aussi le poids de représentations culturelles formant un discours social anxiogène qui pèse sur lui. Tantôt figure de victime, tantôt figure de héros, l’enfant malade est en réalité, le plus souvent, objet sous l’emprise de l’Autre qui s’exerce par la maladie en elle-même mais aussi par l’angoisse parentale bien légitime, ainsi que la fonction médicale et la mise en œuvre de moyens thérapeutiques nécessaires pour obtenir la guérison. Portant une attention particulière à la singularité du discours des enfants rencontrés en oncologie pédiatrique (situés entre 4 et 9 ans), et plus précisément, au processus psychique à l’œuvre dans la symbolisation et dans l’élaboration de leurs théories personnelles, subjectives autour de la maladie, nous soutenons que cette construction d’un sens, qui opère comme une tentative de guérison psychique à partir d’une effraction du réel, définit aussi une implication du sujet dans la maladie, lui permettant ainsi de ne pas rester dans cette position d’objet. De même, lorsque ces enfants manifestent un symptôme qui fait énigme ou qu’ils éprouvent le besoin d’élucider une question, notamment dans l’après-coup des traitements intensifs, comme une sorte de point de réel qui vient fissurer ce qui a pu s’édifier comme sens autour de la maladie, nous posons alors l’hypothèse d’une modification possible de cette position subjective par le travail analytique autour de ce sens qui peut se faire et se défaire grâce à l’équivoque du signifiant, la métaphore et la métonymie, dans la perspective de définir un nouveau mode d’existence, marqué par l’expérience de la maladie, plutôt qu’empêché par celle-ciA sacred figure of the 21st century, the child, when affected by a cancer pathology, is bound to carry the burden of cultural symbols and of the anxiety - inducing social discourse resulting from them. Sometimes considered a victim, sometimes a hero, an ill child is in fact an object under the influence of the Other ; a control acting through the disease itself, but also by the legitimate anguish of parents, the medical corps and the therapeutic measures that are necessary to reach the desired cure. With particular attention to the singularity of the discourse that we met in the paediatric oncology clinic (children aged 4 to 9 years old), and specifically to the psychological processes involved in the symbolization and in the development of their personal and subjective theories surrounding their condition, we believe that this development of a “signification” – acting as a psychological healing attempt following an incursion into reality – also defines the subject’s involvement in the disease, which frees them from being mere objects Furthermore, when these children show a puzzling symptom or feel the need to find the answer to a question, especially in the afterwardsness of intensive treatments – like a real point altering the constructed signification surrounding the disease – we believe that changing this objectification is possible thanks to analytical work around this signification, which can be deconstructed and reconstructed through the significant’s ambivalence, metaphors and metonymy. An attempt to define a new way of existing marked by the experience with the disease, rather than being prevented by it
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Lima, Jose Leonildo. "Vila Bela da Santissima Trindade - MT : sua fala, seus cantos / \ c Jose Leonildo Lima." [s.n.], 2000. http://repositorio.unicamp.br/jspui/handle/REPOSIP/268957.
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Orientador: Tania Maria AlkmimDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem
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Resumo: Este trabalho é o resultado de um estudo sobre a memória do povo de Vila Bela da Santíssima Trindade - MT, a partir de certas marcas lingüísticas presentes nos cantos da dança do Chorado e nos cantos e texto da embaixada do Congo. No primeiro capítulo discutimos alguns aspectos históricos, culturais e lingüísticos de Vila Bela da Santíssima Trindade. Quanto ao aspecto histórico, enfocamos a sua localização, fundação, população, quilombos, ciclo do ouro, sua decadência e a cidade hoje. Sobre o aspecto cultural demos ênfase ao lazer e á educação, às lendas, à feitiçaria, aos rituais do nascimento e da morte. E por último, fizemos breves considerações a respeito de aspectos lingüísticos manifestos na comunidade. No segundo capítulo discutimos, inicialmente, o conceito de Festança. A partir deste conceito, fizemos uma descrição da festa do Divino Espírito Santo, contemplando o seu ritual: a preparação da festa, a peregrinação dos foliões, os rituais da festa nos espaços rural e urbano, os festeiros e a sua escolha. Em seguida, apresentamos uma descrição da dança do Chorado. O texto tem sua seqüência com uma descrição também das festas de São Benedito e do Congo. E por último, fizemos uma caracterização da festa da Santíssima Trindade. No terceiro capítulo temos a análise de algumas marcas lingüísticas previamente selecionadas dos cantos do Chorado e dos cantos e do texto da embaixada do Congo, a partir das quais discutimos alguns aspectos da memória do povo de Vila Bela da Santíssima Trindade. E por último, o trabalho mostra-nos que a festa do Congo, de caráter profano, ainda exerce a sua soberania sobre as festas de caráter religioso e, que diante das marcas lingüísticas analisadas, várias evidências apontaram para a origem dos vila-belenses, curiosidade latente até hoje na comunidade
Abstract: This work is centered in a study about the memory of the people of "Vila Bela da Santíssima Trindade" - MT, starting from certain linguistic marks present in the songs of the dance of Chorado and in the songs and text of the embassy of Congo. The first chapter brings some information about the historical, cultural and linguistic aspects of "Vila Bela da Santíssima Trindade". The second chapter is introduced by the concept about Festivity. Starting from this concept, we made a description about the parties of Divine Espirito Santo, of São Benedito, of Congo, dances of Chorado and at, last, the party of "Santíssima Trindade". The third chapter consists in the analysis about some linguistic marks selected previously of the songs and of the text of the embassy, which starting from them we discussed some aspects of the memory of the people of "Vila Bela da Santíssima Trindade". And at last, the work shows us that the party of Congo, from profane character, still exercises its sovereignty about the parties from religious character and, that by the analyzed linguistic marks, several evidences indicated how being the "vila-belenses" originating from the banto grou
Mestrado
Mestre em Linguística
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Silveira, Graciele Paraguaia 1982. "Aplicação da teoria de conjuntos fuzzy na predição do estadiamento patologico do cancer de prostata." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/307576.
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Orientador: Laercio Luis VenditeDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Matemática, Estatística e Computação Científica
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Resumo: O aumento da incidência de casos de câncer de próstata, nos últimos anos, é um importante problema de saúde pública e um desafio para a ciência médica. Nesta dissertação estudamos a construção de um modelo matemático, que foi desenvolvido para predizer o estadiamento patológico do câncer de próstata. A intenção é auxiliar o especialista no processo de tomada de decisão, com relação ao estágio da doença. O modelo consiste num sistema baseado em regras fuzzy, que combina os dados pré-cirúrgicos - estado clínico, nível de PSA e grau de Gleason - valendo-se de um conjunto de regras, de natureza lingüística, elaborado a partir das informações presentes nos nomogramas já existentes. Com isso esperava-se obter, na saída do sistema, a chance de o indivíduo, com determinado quadro clínico, estar em cada estágio de extensão do tumor: localizado, localmente avançado e metastático. Foram feitas simulações, com dados de pacientes do Hospital das Clínicas/UNICAMP. Os resultados obtidos foram comparados com as probabilidades de Kattan et al, que embora sejam utilizadas nas decisões médicas, são consideradas pessimistas, em relação ao estágio da doença. Com o objetivo de aproximar os resultados, da realidade vivida pelos pacientes, efetuamos algumas modificações na modelagem. Tais mudanças foram suficientes para deixar os resultados mais otimistas e, portanto, mais realísticos
Abstract: The increase of the incidence of prostate cancer is a important problem of public health and a challenge to medical science. In this dissertation, we studied the construction of a mathematical model wich it was developed to predict the pathologic stage of prostate cancer. The intention is to help specialist on the decision process about stage of the disease. The model consists on a system founded in fuzzy laws that it combine the pre-surgicals dates - clinic state, PSA levels and Gleason score - availing of a linguistic laws set made with base on informations of the existents nomograms. Herewith we were hoping to ger person's chance, with clinics characteristics determinates, is in each stage of tumor extension: localized, advanced locally and metastatic. Simulations were made with patient's dates of the Clinics Hospital / UNICAMP. The results were compared with Kattan's probabilities that are used on the medicals decisions. However this probabilities to the disease are considered pessimists. With the aim of approach the results and the reality lived by patients, we did some modifications on the model. This changes were enough to became the results more otimists and therefore more realistics
Mestrado
Biomatematica
Mestre em Matemática Aplicada
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Freccia, Gustavo Weiss. "Critérios de elaboração de programas e seus reflexos na preparação de recitais de canto." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/4710.
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Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG
This work discusses the problem of performance preparation focusing on the repertoire choice for a voice recital and also analyses how the pieces selection and their sequence affect the interpreter during the recital preparation as well as the possible effects of such selection on performance. This work is divided in two parts (A and B): part A being ARTISTIC PRODUCTION, composed by two recitals with a diverse repertoire which were publicly presented and judged by a jury, the second one with repertoire related with the research; and part B being SCIENTIFIC PRODUCTION, composed by a scientific article publishable in the parameters of research in music. The literature on performance preparation points to a certain tradition of organizing the pieces sequence in a chronological way, usually including pieces which are representative of certain periods of Western music History, often focusing on the 18th and 19th century and the first half of the 20th century also. However, such way of organizing the pieces sequence is not always the most organic one for interpreters. Therefore, it is important to investigate how adopting flexible and general criteria (for the recital program structuring) and how applying study strategies might contribute for an optimized artistic performance. We take into account the possibility that a singer can, when performing, be affected by such things as anxiety triggered by an improper pieces sequence selection considering the singer‟s voice and the occasion. Thus, such factors, too, play a major role in the research. This hypothesis is investigated through a review of the performance preparation literature and performance psychology as well as by a survey interviewing singers and going through recital programs (the singers interviewed were music faculty teachers). Finally, the research is concluded that applying such strategies to pieces sequence and selection in singing program repertoire (as part of a performance preparation) brings more satisfactory results for interpreters.
Este trabalho discute a preparação para a performance com enfoque na escolha de repertório para um recital de canto, e analisa como a seleção das peças e sua disposição impactam o intérprete no momento da preparação para um recital, bem como as possíveis interferências desta seleção na performance. O trabalho é dividido em duas partes, a saber: PARTE A: PRODUÇÃO ARTÍSTICA, composta por dois recitais com repertório variado, apresentados publicamente e apreciados por banca sendo o segundo apresentado na defesa com repertório diretamente relacionado com a pesquisa; e PARTE B: PRODUÇÃO CIENTÍFICA, composta por um artigo publicável seguindo modelos da área de música. O texto mostra que a literatura sobre preparação para performance aponta certa tradição de se manter as obras em ordem cronológica, com inclusão de peças representativas de alguns períodos da história da Música Ocidental – geralmente concentrada nos séculos XVIII, XIX e início do XX. Essa, no entanto, nem sempre é a disposição mais orgânica para os intérpretes. Por isso, é pertinente investigar em que medida a adoção de critérios flexíveis e abrangentes na estruturação do programa de recital e na aplicação de estratégias de estudo podem contribuir para um melhor desempenho artístico. Leva-se em conta, nesta investigação, a possibilidade do cantor ser impactado, no momento da performance, por ansiedade, desencadeados por uma escolha e/ou sequência inadequada de obras, ou ainda inadequação à voz do cantor ou à ocasião da performance. Tais fatores são investigados mediante revisão de literatura sobre preparação para performance e psicologia da performance, bem como com a aplicação e avaliação de duas consultas e de programas de recitais realizados por cantores atuantes como docentes em cursos de nível superior. Ao final do artigo confirma-se que a aplicação de estratégias na escolha/ordenação de repertório num programa de canto, durante a preparação para a performance, resulta em resultados mais satisfatórios para os intérpretes.
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Manilich, Elena A. "Hereditary Colorectal Cancer: Information-Based Approach." Cleveland, Ohio : Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1252247671.
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Thesis(Ph.D.)--Case Western Reserve University, 2010Title from PDF (viewed on 2009-12-30) Department of Electrical Engineering and Computer Science Includes abstract Includes bibliographical references and appendices Available online via the OhioLINK ETD Center
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Ferreira, Márcia Lyra. "A integração entre os elementos vocais e cênicos durante a construção da expressividade do cantor lírico e seus aspectos metacognitivos." reponame:Repositório Institucional da UnB, 2015. http://dx.doi.org/10.26512/2015.10.D.20260.
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Dissertação (mestrado)—Universidade de Brasília, Instituto de Artes, Departamento de Música, 2015.Submitted by Fernanda Percia França (fernandafranca@bce.unb.br) on 2016-04-28T19:26:51Z No. of bitstreams: 1 2015_MárciaLyraFerreira_Parcial.pdf: 688617 bytes, checksum: 3af53fdd0f44e17f45a048b92ff24177 (MD5)
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Este estudo de caráter qualitativo e exploratório consiste em uma investigação a respeito da maneira que cantores líricos integram os elementos músico e vocais aos elementos cênicos ao elaborar personagens para obras que demandam encenação. Como forma de delimitação para este trabalho os cantores a serem investigados foram os cantores de óperas do Distrito Federal. Objetivou compreender as formas como os cantores líricos desenvolvem cenicamente suas personagens levando em consideração a integração entre os elementos da técnica vocal (tais como estilo dos períodos, textos cantados) e os elementos cênicos, ou seja, entre a voz e o corpo. A partir da revisão da literatura foi possível perceber que a construção cênica do cantor lírico representa um ciclo em que várias etapas devem ser cumpridas para o alcance da performance ideal. Estas etapas são interdependentes e perpassam por sub-temas como expressividade, habilidades cênicas do cantor lírico, gestos e emoções como recurso expressivo e a preparação corporal do cantor lírico. Como forma de averiguar a teoria com a prática, entrevistas semi-estruturadas foram realizadas envolvendo sete cantores líricos do Distrito Federal. Duas dessas entrevistas funcionaram como pré-teste (entrevista piloto). O resultado almejado para esta pesquisa foi colaborar com outros cantores que passam por dificuldades semelhantes acerca da integração dos elementos cênicos aos elementos músico-vocais, de uma maneira mais natural, orgânica, como também, contribuir para auto-reflexões sobre a elaboração de personagens bem como sobre os conceitos e atitudes práticas necessárias para a atuação cênica do cantor de óperas, além de contribuições para a área da performance em óperas. A partir dos resultados obtidos foi possível compreender que a atuação em ópera demanda uma preparação global do cantor e que consequentemente, lhe exige constantes estudos e capacidade de adaptar-se e readaptar-se aos vários contextos a que estão inseridos.
This qualitative and exploratory study consists of an investigation into the way that opera singers are part of the musician and vocal elements to the scenic elements when designing characters for works that demand scenario. As a way of delimitation for this job singers to be investigated were the opera singers of the Federal District. Aimed at understanding the ways in which singers scenically develop their characters taking into account the integration of the elements of vocal technique (such as style periods, sung texts) and the scenic elements, that is, between the voice and the body. From the literature review it was possible to realize the scenic construction of the opera singer is a cycle in which several steps must be completed to achieve the optimal performance. These steps are interdependent and run through by sub-themes such as expressiveness, performing skills opera singer, gestures and emotions as expressive resource and body preparation of the opera singer. In order to ascertain the theory with practice, semi-structured interviews were conducted involving seven singers of the Federal District. Two of these interviews acted as pretest (pilot interview). The expected result for this research was to collaborate with other singers who go through similar difficulties concerning the integration of scenic elements to the music-vocal elements in a more natural, organic way, but also contribute to self-reflections on the development of characters and how about the concepts and practical steps necessary for the scenic performance of the opera singer, and contributions to the field of performance in operas. From the results it was possible to understand that the opera performance requires an overall preparation of the singer and that consequently, it requires constant study and ability to adapt and re-adapt yourself to the various contexts in which they live.
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Gal, Nathalie. "A dupla metamorfose: o “eu” enquanto intérprete e o “eu” enquanto personagem, numa performance sobre os 7 pecados capitais." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/23385.
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Mestrado em MúsicaEste relatório de projeto debruça-se sobre o papel da metamorfose no processo de construção de um espetáculo ou performance solo, que junta o canto lírico à dramatização, subordinado ao tema dos sete pecados capitais. É um trabalho de cariz autorreflexivo, em que procuro analisar, compreender e descrever, com base em documentação escrita e na minha própria experiência, os processos envolvidos na criação deste tipo de espetáculo, desde a escolha dos materiais utilizados, passando pela construção de uma personagem, a encenação da peça, os ensaios e o processo de trabalho, envolvendo diferentes técnicas e exercícios, até à consecução final da performance.
This project report relates to the role of metamorphosis in the building process of a show or solo performance, bringing together lyric chant and dramatization, subordinated to the subject of the seven capital sins. It is a self-reflexive work by nature, in which I seek to analyze, understand and describe, based in written documents and my own experience, the processes involved in creating this type of show, which includes the choice of materials, the construction of a character, staging a play, rehearsals and work process involving different techniques and exercises until final performance objectives are achieved.
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Souto, Fhoutine Marie Reis. "Bile negra: terrorismo, câncer e seus combates." Pontifícia Universidade Católica de São Paulo, 2015. http://tede2.pucsp.br/handle/handle/2526.
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This work takes as a base the hypothesis that terrorism has been fought throughout history by the nations in a way akin to how Western medicine fights cancer, that unpredictable and unbearable disease that still has no definitive cure. Since its emergence in the end of the 19th century, terrorism this being the definition given by the world s states to violent struggles that endanger their wellbeing and existence has been targeted by procedures intent on physically eliminating it. However, just like tumors that strike again even after being extirpated, the diverse terrorist movements do not give u: The States have tried new treatments which, as radiotherapy and chemotherapy do when dealing with cancer, have a wide-ranging effect and intense, long-lasting side effects. When faced with the impossibility of a cure, both medicine and States invest in prevention and meticulous examinations to identify and eliminate potential threats still in formation. After over a century of fighting, both terrorism and cancer continue to manifest themselves. The victories are always individual, since as long as there is a State there will be terrorism just as cancer is a risk to everybody for as long as there s life, which remains ungovernable
Este trabalho parte da hipótese de que o terrorismo historicamente tem sido combatido pelos Estados como a medicina ocidental combate ao câncer, enfermidade imprevisível e insuportável, para a qual não há solução geral e definitiva. Desde sua emergência, no fim do século XIX, o terrorismo - definição dada pelos Estados às lutas contundentes que colocam em risco sua saúde e existência é alvo de procedimentos que visam sua eliminação física. Porém, como tumores que renascem mesmo após terem sido extirpados, os terrorismos não cessaram. Os Estados, por sua vez, lançaram mão de novos tratamentos, que semelhantes à rádio e a quimioterapia, tinham ação mais abrangente, efeitos colaterais intensos e prolongados. Diante da impossibilidade da cura, medicina e Estados investem em prevenção e exames minuciosos para identificar e eliminar potenciais ameaças ainda em formação. Após mais de um século de combates, terrorismo e câncer continuam a se manifestar. As vitórias são sempre individuais, pois enquanto houver Estado haverá terrorismo, do mesmo modo que o câncer é um risco para cada um enquanto há vida, que permanece ingovernável
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Costa, Mónica Patrícia de Almeida. "Qualidade de vida, espiritualidade e seus correlatos em mulheres com cancro da mama." Master's thesis, [s.n.], 2010. http://hdl.handle.net/10284/1670.
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Dissertação de Mestrado apresentada à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Psicologia, especialização em Psicologia da Educação e Intervenção ComunitáriaOs objectivos do presente estudo são: a) comparar a Qualidade de Vida (QDV) de mulheres submetidas a mastectomia versus cirurgia conservadora; b) explorar a relação entre a QDV e idade; c) explorar a relação entre QDV e escolaridade; d) explorar a relação entre QDV e tempo de diagnóstico; e) comparar o Bem-Estar Espiritual (BEE) de mulheres submetidas a mastectomia versus cirurgia conservadora; f) explorar a relação entre BEE e idade; g) explorar a relação entre BEE e escolaridade; h) explorar a relação entre BEE e tempo de diagnóstico; i) explorar a relação entre BEE e QDV em mulheres com cancro da mama submetidas a cirurgia. Por último, pretende-se, ainda, identificar as características dos elementos da amostra que apresentam pior QDV e pior BEE e explorar a relação entre as respostas a dois instrumentos de avaliação da espiritualidade. Para o efeito, foram avaliadas 60 mulheres com uma idade média de 55,72 anos, dais quais 40 eram casadas, 54 não estavam no activo, 44 haviam-se submetido a quimioterapia, 40 a radioterapia, 30 a mastectomia e 30 a cirurgia conservadora. Recorreu-se à administração assistida do Questionário Sócio-demográfico e Clínico elaborado para o efeito, do “The Funcional Assessement of Cancer Therapy – Breast” FACT – B), para avaliar a QDV, “The Functional Assessementof Chronic Ilness Therapy – Spiritual Well-Being Scale” (FACIT Sp-12), para avaliar a espiritualidade, mais concretamente o BEE e da Escala de Avaliação de Espiritualidade em Contextos de Saúde. Verificou-se que quanto maior o BEE maior a QDV. Contrariamente ao que indica a literatura, não se verificaram diferenças na QDV em mulheres com cancro da mama tendo em conta o tipo de cirurgia realizada, nem correlações estatisticamente significativas entre QDV e: tempo de diagnóstico, idade ou escolaridade. No que diz respeito `espiritualidade, e também, contrariamente `literatura não se verificaram correlações estatisticamente significativas entre BEE e: tempo de diagnóstico, idade ou escolaridade. Nas mulheres com pior QDV e pior BEE, verificaram-se algumas características relatadas na literatura. Por sua vez, a existência de uma correlação forte/alta positiva entre o FACIT Sp-12 e a EAECS, indica uma relação próxima entre os dois construtos e que os dois instrumentos não estão a avaliar exactamente o mesmo conceito. Desta forma, a relação entre o BEE e QDV sugere a possibilidade do BEE ser alvo de intervenção no âmbito da promoção da QDV de mulheres com cancro da mama submetidas a cirurgia, sendo para isso importante explorar novas estratégias de apoio que premeiem uma intervenção mais comunitária, utilizando todos os recursos disponíveis para promover uma melhor QDV. Os restantes resultados encontrados exigem novos estudos, até porque as características das participantes, os instrumentos e o próprio procedimento podem ser a causa da sua divergência relativamente à literatura pré-existente. The objectives of this study are: a) compare the quality of life (QOL) of women undergoing mastectomy versus conservative surgery, b) explore the relationship between QOL and age, c) explore the relationship between QOL and education, d) explore the relationship between QOL and delayed diagnosis, e) comparing the Spiritual Well-Being (BEEN) from women undergoing mastectomy versus conservative surgery; f) explore the relationship between BEE and age; g) explore the relationship between BEE and schooling; h) explore the relationship between BEE and time of diagnosis; i) explore the relationship between BEE and QOL in women with breast cancer undergoing surgery. Finally, the intention is also to identify the characteristics of the sample elements that have worse QOL and BEE and explore the relationship between responses to two instruments for assessing spirituality. To this end, we evaluated 60 women with a mean age of 55.72 years, of wich 40 were married, 54 were not in active, 44 had undergone chemotherapy, 40 radiotherapy, 30 mastectomy and 30 conservative surgery. Appealed to the administration assisted Questionnaire Socio-demographic and Clinical prepared for the purpose of “The Functional Assessment of Cancer Therapy – Breast (FACT-B to assess QOL”, The Functional Assessment of Chronic Ilness Therapy – Spiritual Well-Being Scale (FACIT-Sp 12), to assess spirituality, specifically BEE and the Scale for Assessment of Spirituality in Health Contexts. It was found that the higher the BEE higher QOL. Contrary to literature indicates, there were no differences in the QOL in women with breast cancer taking into account the type of surgery, nor statistically significant correlations between QOL and: time of diagnosis, age or education. Regarding spirituality, and also, contrary to literature there were no statistically significant correlations between BEE and as time of diagnosis, age or education. In women worse QOL and BEE there was some characteristics that literature say. In the existence of strong correlation positive between the FCIT-Sp and 12 EAECS, indicates a close relationship between these constructs and that both instruments are not evaluated exactly the sample concept. Thus, the relationship between BEE and QOL suggests the possibility of BEE can be targeted for the intervention in promotion of QOL in women with breast cancer undergoing surgery, so important to explore new strategies to reward support a more community using all available resources to promote a better QOL. The remaining results require further study, because the characteristics of participants, the instruments and the procedure itself may be the cause of their disagreement on the pre-existing literature.
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Oliveira, Tiago Filipe Rodrigues de. "Via de sinalização mTOR e efeito dos seus inibidores no tratamento do cancro." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/3964.
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Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências FarmacêuticasO cancro é o termo utilizado para referir todos os diferentes tipos de tumores malignos, porém estes podem adotar uma nomenclatura mais específica tendo em conta o local onde se desenvolveram. O cancro é responsável pela morte de quase 8 milhões de pessoas por ano em todo o mundo, número este que tem vindo a aumentar com os anos. Existem inúmeros fatores que podem aumentar o risco de desenvolvimento de um tumor maligno, daí ser extremamente importante, conhece-los para que possam ser evitados e deste modo prevenir o desenvolvimento desta terrível patologia. É neste contexto, que surge o estudo da via de sinalização do mTOR, que se apresenta alterada em mais de 50% dos cancros que surgem na atualidade. A proteína mTOR desempenha um papel crucial nesta via de sinalização sendo responsável pela regulação do crescimento celular e síntese de proteínas. Alterações nesta via estão associadas com a tumorigénese, angiogénese, crescimento do tumor e metastização O mTOR está inserido na via PI3K/AKT/mTOR e divide-se em dois complexos: mTORC1 e mTORC2. A jusante do mTOR encontramos duas proteínas fundamentais, a 4EBP1 e p70S6K1, proteínas envolvidas em processos de proliferação, sobrevivência celular e angiogénese, processos fundamentais no desenvolvimento de mutações que podem conduzir a cancro. A rapamicina foi o primeiro inibidor do mTOR descoberto e aprovado para o tratamento do cancro, no entanto, as suas propriedades farmacocinéticas e farmacodinâmicas pouco favoráveis levaram ao desenvolvimento dos análogos da rapamicina: o temsirolimus e o everolimus são exemplos desta classe de fármacos. Contudo, com o evoluir da investigação foram descobertos mais fármacos com a capacidade de inibir a via do mTOR. Um melhor entendimento do cancro, e desta via de sinalização poderá levar ao desenvolvimento de fármacos mais eficazes e específicos ao tipo de tumor, que usados isolados ou em combinação, podem melhorar a qualidade de vida destes pacientes.
Cancer is the term used when refering to different types of malignant tumors, howewer, they can have a more specific definition given where they developed. Cancer is responsible for the deaths of nearly 8 million people worldwide, and this number tends to increase. There are numerous factors that can increase the risk of developing a malignant tumor, it is extremely important to know them, so they can be avoided and thus prevent the development of this terrible disease. In this context the investigation arises of the mTOR signaling pathway, which is altered in more than 50% of cancers. MTOR protein plays a crucial role in this signaling pathway and is responsible for the regulation of cell growth and protein synthesis. Alterations in this pathway are associated with tumorigenesis, angiogenesis, tumor growth and metastasis. mTOR is inserted into the PI3K/AKT/mTOR pathway and is divided into two complexes: mTORC1 and mTORC2. Downstream of mTOR there are two fundamental proteins, the 4EBP1 and the p70S6K1. These proteins are involved in proliferation, cell survival and angiogenesis, key processes in the development of mutations that can lead to cancer. Rapamycin was the first mTOR inhibitor approved for the treatment of cancer, howewer its poor pharmacokinetic and pharmacodynamic properties led to the development of rapamycin analogues. Temsirolimus and everolimus are examples of this class of drugs. However, with the progress of the investigation there were more drugs discovered with the ability to inhibit the mTOR pathway. A better understanding of cancer, specificly signaling pathway may lead to the development of more effective and targeted drugs, used alone or in combination, to the tumor and thus improve the quality of life of this patients.
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Huard, Thérèse. "Le sens donné au cancer en relation avec les stratégies de coping utilisées /." Thèse, Trois-Rivières : Université du Québec à Trois-Rivières, 2000. http://www.uqtr.ca/biblio/notice/resume/03-2216502R.html.
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Huard, Thérèse. "Le sens donné au cancer en relation avec les stratégies de coping utilisées." Thèse, Université du Québec à Trois-Rivières, 2000. http://depot-e.uqtr.ca/3073/1/000671512.pdf.
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Li, Xiaobing. "Automatic image segmentation based on level set approach: application to brain tumor segmentation in MR images." Reims, 2009. http://theses.univ-reims.fr/exl-doc/GED00001120.pdf.
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L'objectif de la thèse est de développer une segmentation automatique des tumeurs cérébrales à partir de volumes IRM basée sur la technique des « level sets ». Le fonctionnement «automatique» de ce système utilise le fait que le cerveau normal est symétrique et donc la localisation des régions dissymétriques permet d'estimer le contour initial de la tumeur. La première étape concerne le prétraitement qui consiste à corriger l'inhomogénéité de l'intensité du volume IRM et à recaler spatialement les volumes d'IRM d'un même patient à différents instants. Le plan hémisphérique du cerveau est recherché en maximisant le degré de similarité entre la moitié du volume et de sa réflexion. Le contour initial de la tumeur est ainsi extrait à partir de la dissymétrie entre les deux hémisphères. Ce contour initial est évolué et affiné par une technique de « level set » afin de trouver le contour réel de la tumeur. Les critères d'arrêt de l'évolution ont été proposés en fonction des propriétés de la tumeur. Finalement, le contour de la tumeur est projetée sur les images adjacentes pour former les nouveaux contours initiaux. Ce traitement est itéré sur toutes les coupes pour obtenir la segmentation de la tumeur en 3D. Le système ainsi réalisé est utilisé pour suivre un patient pendant toute la période thérapeutique, avec des examens tous les quatre mois, ce qui permet au médecin de contrôler l'état de développement de la tumeur et ainsi d'évaluer l'efficacité du traitement thérapeutique. La méthode a été évaluée quantitativement par la comparaison avec des tracés manuels des experts. De bons résultats sont obtenus sur des images réelles IRMThe aim of this dissertation is to develop an automatic segmentation of brain tumors from MRI volume based on the technique of "level sets". The term "automatic" uses the fact that the normal brain is symmetrical and the localization of asymmetrical regions permits to estimate the initial contour of the tumor. The first step is preprocessing, which is to correct the intensity inhomogeneity of volume MRI and spatially realign the MRI volumes of the same patient at different moments. The plan hemispherical brain is then calculated by maximizing the degree of similarity between the half of the volume and his reflexion. The initial contour of the tumor can be extracted from the asymmetry between the two hemispheres. This initial contour is evolved and refined by the technique "level set" in order to find the real contour of the tumor. The criteria for stopping the evolution have been proposed and based on the properties of the tumor. Finally, the contour of the tumor is projected onto the adjacent images to form the new initial contours. This process is iterated on all slices to obtain the segmentation of the tumor in 3D. The proposed system is used to follow up patients throughout the medical treatment period, with examinations every four months, allowing the physician to monitor the state of development of the tumor and evaluate the effectiveness of the therapy. The method was quantitatively evaluated by comparison with manual tracings experts. Good results are obtained on real MRI images