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Journal articles on the topic 'CAP-37'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Pereira, H. Anne, John K. Spitznagel, Jan Pohl, et al. "CAP 37, A 37 kD human neutrophil granule cationic protein shares homology with inflammatory proteinases." Life Sciences 46, no. 3 (1990): 189–96. http://dx.doi.org/10.1016/0024-3205(90)90104-y.

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2

Stys, Peter K., Stephen G. Waxman, and Bruce R. Ransom. "Effects of Temperature on Evoked Electrical Activity and Anoxic Injury in CNS White Matter." Journal of Cerebral Blood Flow & Metabolism 12, no. 6 (1992): 977–86. http://dx.doi.org/10.1038/jcbfm.1992.135.

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Temperature is known to influence the extent of anoxic/ischemic injury in gray matter of the brain. We tested the hypothesis that small changes in temperature during anoxic exposure could affect the degree of functional injury seen in white matter, using the isolated rat optic nerve, a typical CNS white matter tract (Foster et al., 1982). Functional recovery after anoxia was monitored by quantitative assessment of the compound action potential (CAP) area. Small changes in ambient temperature, within a range of 32 to 42°C, mildly affected the CAP of the optic nerve under normoxic conditions. Re

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3

Tokunaga, K., K. Kinugasa, T. Meguro, et al. "Embolization of Cerebral Arteriovenous Malformations with Cellulose Acetate Polymer." Interventional Neuroradiology 4, no. 1_suppl (1998): 117–20. http://dx.doi.org/10.1177/15910199980040s125.

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To test the usefulness of a cellulose acetate polymer(CAP) solution for brain arteriovenous malformations (AVMs), we analyzed the clinical and histological results of patients with AVMs embolized using CAP solution. We reviewed the cases of six patients with cerebral AVMs treated by embolization prior to surgical resection. We used two types of CAP solutions, CAP-M and CAP-L, which are mixtures of 250 mg of solid CAP and 1800 or 2250 mg of bismuth trioxide dissolved in 5.5 or 7.0 ml of dimethyl sulfoxide, respectively. All patients underwent surgical resection 1 to 37 days after the embolizati

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4

Tsikourkitoudi, Vasiliki, Jens Karlsson, Padryk Merkl, Edmund Loh, Birgitta Henriques-Normark, and Georgios A. Sotiriou. "Flame-Made Calcium Phosphate Nanoparticles with High Drug Loading for Delivery of Biologics." Molecules 25, no. 7 (2020): 1747. http://dx.doi.org/10.3390/molecules25071747.

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Nanoparticles exhibit potential as drug carriers in biomedicine due to their high surface-to-volume ratio that allows for facile drug loading. Nanosized drug delivery systems have been proposed for the delivery of biologics facilitating their transport across epithelial layers and maintaining their stability against proteolytic degradation. Here, we capitalize on a nanomanufacturing process famous for its scalability and reproducibility, flame spray pyrolysis, and produce calcium phosphate (CaP) nanoparticles with tailored properties. The as-prepared nanoparticles are loaded with bovine serum

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5

Gavrilina, N. S., L. Yu Ilchenko, G. A. Sedova, I. G. Fedorov та I. G. Nikitin. "СORRECTION OF MALNUTRITION IN PATIENTS WITH CHRONIC PANCREATITIS". Russian Archives of Internal Medicine 9, № 1 (2019): 70–80. http://dx.doi.org/10.20514/2226-6704-2019-9-1-70-80.

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Aim:To estimate the frequency of occurrence malnutrition and efficacy its correction in chronic pancreatitis (CP).Materials and methods:148 patients were examined. Group I included 71 people with chronic alcoholic pancreatitis (CAP); group II — 77 patients with chronic obstructive pancreatitis (COP). Trophological status (TS) was investigated by criteria of V.M. Luft. Lymphocytes, pancreatic amylase, lipase, total protein, albumin, urine diastase and faecal elastase-1 were investigated before and after treatment. Two treatment options were used: combination therapy (CT, (Mezym-forte 10500 USP/

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6

Alfaro-Navarro, Jose Luis, Jose Mondejar-Jimenez, Manuel Vargas-Vargas, Juan Carlos Gazquez-Abad, and Jose Felipe Jimenez- Guerrero. "The Effects Of The Distribution Of Agricultural Direct Payments." Review of Business Information Systems (RBIS) 15, no. 5 (2011): 25–30. http://dx.doi.org/10.19030/rbis.v15i5.6015.

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The Common Agricultural Policy (the CAP) is the most important common policy of the European Union, for which reason it traditionally monopolizes a large part of the European Union budget. Without doubt, the aids that farms receive from this policy are the pillar on which it sustains the battered agricultural sectors. Among CAP aid, direct payments are particularly important, in 2008 accounting for about 37% of the total EU budget. The main objective of this paper is to analyse the effects that the distribution of the CAP direct payments have on the agrarian economy. Specifically, we have anal

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7

Kawamukai, M., J. Gerst, J. Field, et al. "Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe." Molecular Biology of the Cell 3, no. 2 (1992): 167–80. http://dx.doi.org/10.1091/mbc.3.2.167.

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We have identified, cloned, and studied a gene, cap, encoding a protein that is associated with adenylyl cyclase in the fission yeast Schizosaccharomyces pombe. This protein shares significant sequence homology with the adenylyl cyclase-associated CAP protein in the yeast Saccharomyces cerevisiae. CAP is a bifunctional protein; the N-terminal domain appears to be involved in cellular responsiveness to RAS, whereas loss of the C-terminal portion is associated with morphological and nutritional defects. S. pombe cap can suppress phenotypes associated with deletion of the C-terminal CAP domain in

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8

Nguyen, Thinh Duc, Thu Thi Nguyet Nguyen, Diem Ngoc Duong, Son Pham Ngoc Chu, and Thuoc Linh Tran. "Preparation of anti-chloramphenicol rabbit antibody." Science and Technology Development Journal 19, no. 4 (2016): 5–13. http://dx.doi.org/10.32508/stdj.v19i4.689.

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Chloramphenicol (CAP) is a broad-spectrum antibiotic of high toxicity on human therefore it is being strictly controlled in food. We are interested in the development of a method of effective extraction of CAP in food based on the immunological principle using specific anti-CAP antibody combining with LC/MS/MS for the analysis of the residual CAP in food meeting the international standard. In this article, we reported experimental results on the preparation of anti-CAP rabbit antibody. Conjugative antigen between CAP and the carrier protein, bovine serum albumin, BSA (CAP-BSA) was successfully

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9

TANAKA, J., N. ISHIWADA, A. WADA, et al. "Incidence of childhood pneumonia and serotype and sequence-type distribution inStreptococcus pneumoniaeisolates in Japan." Epidemiology and Infection 140, no. 6 (2011): 1111–21. http://dx.doi.org/10.1017/s0950268811001592.

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SUMMARYThe 7-valent pneumococcal conjugate vaccine (PCV7) is reported to decrease the incidence of community-acquired pneumonia (CAP) in children. To determine the annual incidence of CAP before the introduction of PCV7, we counted the number of children hospitalized with CAP between 2008 and 2009 in Chiba City, Japan. We investigated serotype and multilocus sequence typing (MLST) forStreptococcus pneumoniaeisolates in CAP cases. The annual incidence of hospitalized CAP in children aged <5 years was 17·6 episodes/1000 child-years. In 626 episodes,S. pneumoniaewas dominant in 14·7% and 0·8%

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10

Mohamed, Mansour H., and Kyle K. Wetzel. "3D Woven Carbon/Glass Hybrid Spar Cap for Wind Turbine Rotor Blade." Journal of Solar Energy Engineering 128, no. 4 (2006): 562–73. http://dx.doi.org/10.1115/1.2349543.

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This paper presents the design and analysis for a spar cap for a wind turbine rotor blade. The cap is formed of an integral, unitary 3D woven material (3WEAVE®) having constant thickness; spar cap weight is varied and controlled by appropriately tapering the cap width from the blade root to tip. This analysis is employed for 24-m and 37-m rotor blades. These studies are conducted parametrically, examining a range of 3WEAVE® materials incorporating varying fractions of glass and carbon fibers, and hence exhibiting a range of structural properties and material costs. These parametric studies are

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11

Fascelli, Michele, Rachael Sussman, Thomas P. Frye, et al. "How reliable is a negative MRI/TRUS fusion biopsy? The predictive value of targeted biopsy for prostate cancer." Journal of Clinical Oncology 33, no. 7_suppl (2015): 51. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.51.

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51 Background: Multiparametric MRI (mpMRI) has been shown to improve clinically significant prostate cancer (CaP) detection. Targeted biopsy using MRI/transrectal ultrasonography (TRUS) fusion is a novel diagnostic tool. The negative predictive value (NPV) of an MRI/TRUS fusion targeted biopsy of a suspicious lesion on mpMRI was determined. Methods: 30 of 181 men who underwent prostatectomy from 2008-2014 were retrospectively identified and had at least one lesion on mpMRI negative for cancer on MRI/TRUS fusion biopsy. Whole mount pathology specimens, gold standard for CaP detection, were alig

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12

Nagaoka, Isao, Satoko Hirota, François Niyonsaba, Hiroshi Tamura, Shigenori Tanaka, and Michimasa Hirata. "LPS-neutralizing activities of cathelicidin family of antibacterial polypeptides LL-37 and CAP 11." Ensho Saisei 22, no. 2 (2002): 131–38. http://dx.doi.org/10.2492/jsir.22.131.

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13

Bansal, Anju, Anup Gupta, and Sunita Saxena. "Correlation of p53 immunoexpression with DNA ploidy and apoptotic index in subsets of prostate cancer: A marker reiterated in progression and recurrence of prostate cancer." South Asian Journal of Cancer 04, no. 02 (2015): 088–90. http://dx.doi.org/10.4103/2278-330x.155693.

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Abstract Background: Prediction of biological behavior in patients of prostate cancer (CaP) is a major challenge as current parameters only partially meet the need for prognostication. p53 as a prognostic indicator has been studied in several human cancers, including breast, lung, and colorectal carcinoma. However, its significance as a predictive biomarker for CaP is less well-studied. Materials and Methods: This study included 125 cases of CaP, 27 cases of prostatic intraepithelial neoplasia and 25 cases of benign prostatic hyperplasia. Immunohistochemical assessment for p53 nuclear protein

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14

Pelletier, J., and N. Sonenberg. "Photochemical cross-linking of cap binding proteins to eucaryotic mRNAs: effect of mRNA 5' secondary structure." Molecular and Cellular Biology 5, no. 11 (1985): 3222–30. http://dx.doi.org/10.1128/mcb.5.11.3222.

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We used UV light-induced cross-linking to study the interactions of cap binding proteins with the 5' cap structure of eucaryotic mRNAs. Thymidine kinase gene (herpes simplex virus type 1) transcripts prepared in vitro using the SP6 RNA polymerase transcription system were capped and methylated posttranscriptionally with [alpha-32P]GTP and S-adenosyl-L-methionine to yield cap-labeled transcripts. Irradiation of capped transcripts with crude rabbit reticulocyte initiation factors in the presence of ATP-Mg2+ resulted in the cap-specific cross-linking of two polypeptides with molecular masses of 2

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15

Pelletier, J., and N. Sonenberg. "Photochemical cross-linking of cap binding proteins to eucaryotic mRNAs: effect of mRNA 5' secondary structure." Molecular and Cellular Biology 5, no. 11 (1985): 3222–30. http://dx.doi.org/10.1128/mcb.5.11.3222-3230.1985.

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We used UV light-induced cross-linking to study the interactions of cap binding proteins with the 5' cap structure of eucaryotic mRNAs. Thymidine kinase gene (herpes simplex virus type 1) transcripts prepared in vitro using the SP6 RNA polymerase transcription system were capped and methylated posttranscriptionally with [alpha-32P]GTP and S-adenosyl-L-methionine to yield cap-labeled transcripts. Irradiation of capped transcripts with crude rabbit reticulocyte initiation factors in the presence of ATP-Mg2+ resulted in the cap-specific cross-linking of two polypeptides with molecular masses of 2

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16

Kösters, Jutta, Valérie Galéa-Clolus, Pierre Clolus, Birgit Heying, and Rainer Pöttgen. "Orthorhombic sulfur from Cap Garonne, Mine du Pradet." Zeitschrift für Naturforschung B 74, no. 1 (2019): 5–8. http://dx.doi.org/10.1515/znb-2018-0202.

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AbstractNatural orthorhombic sulfur (α-S8), grown on galena crystals from Cap Garonne, Mine du Pradet, France, were studied by single crystal X-ray diffraction at 150 K: Fddd, a=1036.75(5), b=1273.54(7), c=2437.85(13) pm, wR=0.0380, 1433 F2 values (all data) and 37 variables. Refinements of the occupancy parameters along with EDX data indicate pure sulfur.

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17

Manunga, Jesse, and Jemi Olak. "Is Thoracoscopic Decortication Sufficient for the Treatment of Empyema?" American Surgeon 76, no. 10 (2010): 1050–54. http://dx.doi.org/10.1177/000313481007601005.

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Before thoracoscopy became popular in the 1990s, thoracotomy and decortication was the treatment of choice for empyema thoracis not responding to tube thoracostomy. An Institutional Review Board-approved, retrospective review of all patients treated for empyema between September 1, 2006, and August 31, 2009, at Kern Medical Center was conducted. A total of 37 patients (male = 33; female = 4) with a mean age of 43.7 years were treated. Empyema developed after community-acquired pneumonia (CAP) in 27, traumatic hemothorax (TH) in nine, and other cause in one. For 34 of 36 patients (91%), a thora

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18

Bellew, Shawna, Carlos G. Grijalva, Derek J. Williams, et al. "Pneumococcal and Legionella Urinary Antigen Tests in Community-acquired Pneumonia: Prospective Evaluation of Indications for Testing." Clinical Infectious Diseases 68, no. 12 (2018): 2026–33. http://dx.doi.org/10.1093/cid/ciy826.

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Abstract Background Adult, community-acquired pneumonia (CAP) guidelines from the Infectious Diseases Society of America (IDSA) and American Thoracic Society (ATS) include indications for urinary antigen tests (UATs) for Streptococcus pneumoniae (SP) and Legionella pneumophila (LP). These recommendations were based on expert opinions and have not been rigorously evaluated. Methods We used data from a multicenter, prospective, surveillance study of adults hospitalized with CAP to evaluate the sensitivity and specificity of the IDSA/ATS UAT indications for identifying patients who test positive.

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19

Donà, Daniele, Dora Luise, Liviana Da Dalt, and Carlo Giaquinto. "Treatment of Community-Acquired Pneumonia: Are All Countries Treating Children in the Same Way? A Literature Review." International Journal of Pediatrics 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/4239268.

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Background. Pneumonia represents an important threat to children’s health in both developed and developing countries. In the last 10 years, many national and international guidelines on the treatment of pediatric CAP have been published, in order to optimize the prescription of antibiotics and limit their cost and side effects. However, the practical implementation of these guidelines is still limited.Main Text. We analyzed the current recommendations for the therapy of pediatric community-acquired pneumonia (CAP) that all converge on the identification of aminopenicillins and beta-lactams as

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20

Man, Yi, Yi Li Qu, Peng Wang, et al. "Experimental Study of Biomimetic Mineralization on the Surface of Piezoelectric Pulp-Cap Film." Key Engineering Materials 336-338 (April 2007): 1707–10. http://dx.doi.org/10.4028/www.scientific.net/kem.336-338.1707.

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To study the biomimetic mineralization behaviour of piezoelectric pulp-cap films, bioelectret chitosan films were prepared by polarization in an electric field and soaked in PBS with lysozyme for piezoelectricity attenuation testing. The results showed that comparing these with samples stored in an exsiccator, the films soaked in PBS had accelerated d33 loss. Calcium phosphate crystals nucleated and grew on the surfaces of samples soaked in supersaturated calcification solution at 37 for 1, 6, 12 and 24 h. OCP and HA were found to co-precipitate on the surfaces within 24 h of immersion. This n

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Kamat, Ishan S., Vignesh Ramachandran, Harish Eswaran, Danielle Guffey, and Daniel M. Musher. "Procalcitonin to Distinguish Viral From Bacterial Pneumonia: A Systematic Review and Meta-analysis." Clinical Infectious Diseases 70, no. 3 (2019): 538–42. http://dx.doi.org/10.1093/cid/ciz545.

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Abstract Because of the diverse etiologies of community-acquired pneumonia (CAP) and the limitations of current diagnostic modalities, serum procalcitonin levels have been proposed as a novel tool to guide antibiotic therapy. Outcome data from procalcitonin-guided therapy trials have shown similar mortality, but the essential question is whether the sensitivity and specificity of procalcitonin levels enable the practitioner to distinguish bacterial pneumonia, which requires antibiotic therapy, from viral pneumonia, which does not. In this meta-analysis of 12 studies in 2408 patients with CAP t

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PAUL, Jayanta, Raj Vigna VENUGOPAL, Lorance PETER, Kula Naresh Kumar SHETTY, and Mohit P. SHETTI. "MEASUREMENT OF CONTROLLED ATTENUATION PARAMETER: A SURROGATE MARKER OF HEPATIC STEATOSIS IN PATIENTS OF NONALCOHOLIC FATTY LIVER DISEASE ON LIFESTYLE MODIFICATION - A PROSPECTIVE FOLLOW-UP STUDY." Arquivos de Gastroenterologia 55, no. 1 (2018): 7–13. http://dx.doi.org/10.1590/s0004-2803.201800000-07.

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ABSTRACT BACKGROUND: Liver biopsy is a gold standard method for hepatic steatosis assessment. However, liver biopsy is an invasive and painful procedure and can cause severe complications therefore it cannot be frequently used in case of follow-up of patients. Non-invasive assessment of steatosis and fibrosis is of growing relevance in non-alcoholic fatty liver disease (NAFLD). To evaluate hepatic steatosis, transient elastography with controlled attenuation parameter (CAP) measurement is an option now days. OBJECTIVE: Aim of this study is to evaluate role of measurement of controlled attenuat

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Llull, Daniel, Rosario Muñoz, Rubens López, and Ernesto García. "A Single Gene (tts) Located outside the cap Locus Directs the Formation of Streptococcus pneumoniae Type 37 Capsular Polysaccharide." Journal of Experimental Medicine 190, no. 2 (1999): 241–52. http://dx.doi.org/10.1084/jem.190.2.241.

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The molecular aspects of the type 37 pneumococcal capsular biosynthesis, a homopolysaccharide composed of sophorosyl units (β-d-Glc-(1→2)-β-d-Glc) linked by β-1,3 bonds, have been studied. Remarkably, the biosynthesis of the type 37 capsule is driven by a single gene (tts) located far apart from the cap locus responsible for capsular formation in all of the types characterized to date in Streptococcus pneumoniae. However, a cap37 locus virtually identical to the cap33f cluster has been found in type 37 strains, although some of its genes are inactivated by mutations. The tts gene has been sequ

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24

Surdacki, Michał A., Marcin Major, Michał Chyrchel, et al. "Urgent Pericardiocentesis Is More Frequently Needed After Left Circumflex Coronary Artery Perforation." Journal of Clinical Medicine 9, no. 9 (2020): 3043. http://dx.doi.org/10.3390/jcm9093043.

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Background: Coronary artery perforation (CAP) is a rare but potentially life-threatening complication of percutaneous coronary interventions (PCIs) due to the risk of cardiac tamponade. Strikingly, in contrast to numerous analyses of CAP predictors, only few studies were focused on the predictors of tamponade after PCI, once iatrogenic CAP has occurred. Our aim was to search for clinical and periprocedural characteristics, including the coronary artery involved, associated with the development of acute cardiac tamponade among patients experiencing CAP. Methods: From the medical records of nine

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Fok, Mark C., Zahra Kanji, Rajesh Mainra, and Michael Boldt. "Characterizing and Developing Strategies for the Treatment of Community-Acquired Pneumonia at a Community Hospital." Canadian Respiratory Journal 9, no. 4 (2002): 247–52. http://dx.doi.org/10.1155/2002/697424.

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BACKGROUND: Patients admitted to Lions Gate Hospital, North Vancouver, British Columbia, with a primary diagnosis of community-acquired pneumonia (CAP) have a mean length of stay (LOS) of 9.1 days compared with 7.9 days for peer group hospitals. This difference of 1.2 days results in an annual potential savings of 406 bed days and warranted an investigation into the management of CAP.OBJECTIVE: To characterize and provide recommendations for the management of CAP.METHODS: A retrospective chart review of patients admitted with a primary diagnosis of CAP between May 1, 2000 and August 31, 2000.R

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Guney, Mert, Aiganym Kumisbek, Zhanel Akimzhanova, et al. "Environmental Partitioning, Spatial Distribution, and Transport of Atmospheric Mercury (Hg) Originating from a Site of Former Chlor-Alkali Plant." Atmosphere 12, no. 2 (2021): 275. http://dx.doi.org/10.3390/atmos12020275.

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Mercury (Hg) is one of the trace toxic and bioaccumulative global pollutants, and due to its long atmospheric lifetime, it presents a significant global challenge. The present study (1) utilizes total gaseous mercury (TGM) measurements made around a former Hg-cell chlor-alkali plant (CAP) located in Pavlodar, Kazakhstan, and predicts the spatial distribution of Hg over its premises and the nearby city. It then (2) estimates the environmental repartition of Hg deposited by the CAP using three fugacity models of varying complexity: Level I, QWASI, and HERMES. Finally, it (3) predicts long-range

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27

Satram-Hoang, Sacha, Devi Ramanan, Luen F. Lee, Shui Yu, Carolina M. Reyes, and Edward McKenna. "Comparative effectiveness of chemotherapy in elderly patients with metastatic colorectal cancer." Journal of Clinical Oncology 30, no. 4_suppl (2012): 463. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.463.

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463 Background: The management of metastatic colorectal cancer (mCRC) has evolved considerably with advances in chemotherapeutic agents that have led to improved outcomes. Less is known about the benefits of newer agents in the real-world setting. The objective of this study was to evaluate treatment patterns and survival in older, demographically diverse mCRC patients. Methods: Using the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database, we conducted a retrospective cohort analysis of 5931 stage IIIB, IIIC and IV CRC patients diagnosed between 1/1/ 2000 – 12/31/2007,

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Muthigi, Akhil, Arvin Koruthu George, Amogh Iyer, et al. "Missing the mark? Prostate cancer upgrading by systematic biopsy over fusion biopsy." Journal of Clinical Oncology 34, no. 2_suppl (2016): 62. http://dx.doi.org/10.1200/jco.2016.34.2_suppl.62.

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62 Background: Multiparametric MRI (mpMRI) and fusion biopsy (FBx) detect more high risk prostate cancer (CaP) and less low risk CaP than standard systematic biopsy (SBx). However, there remains a small subset of patients where SBx captures higher grade disease than FBx. We aim to identify potential reasons for failure of FBx biopsy in detection of clinically significant (CS) CaP. Methods: A review was performed of a prospectively maintained database of patients undergoing mpMRI followed by FBx and SBx in the same session from 2007−2014. Patients upgraded to higher risk disease based on SBx re

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Ruedas, John B., and Jacques Perrault. "Insertion of Enhanced Green Fluorescent Protein in a Hinge Region of Vesicular Stomatitis Virus L Polymerase Protein Creates a Temperature-Sensitive Virus That Displays No Virion-Associated Polymerase Activity In Vitro." Journal of Virology 83, no. 23 (2009): 12241–52. http://dx.doi.org/10.1128/jvi.01273-09.

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ABSTRACT The RNA-dependent RNA polymerase of viruses belonging to the order Mononegavirales is part of a large multifunctional L protein that also catalyzes viral mRNA capping and cap methylation. The L protein of this diverse group of agents displays six blocks of conserved sequences. The precise relationship between these conserved regions and individual functions is largely unknown, except for “domain” VI that clearly encodes a viral mRNA cap methylase. The L protein of morbilliviruses (family Paramyxoviridae) was reported to tolerate insertion of the enhanced green fluorescent protein (EGF

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BLAKE, A., B. M. NJANPOP-LAFOURCADE, J. N. TELLES, et al. "Evaluation of chest radiography,lytAreal-time PCR, and other routine tests for diagnosis of community-acquired pneumonia and estimation of possible attributable fraction of pneumococcus in northern Togo." Epidemiology and Infection 145, no. 3 (2016): 583–94. http://dx.doi.org/10.1017/s0950268816002211.

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SUMMARYStreptococcus pneumoniae(Spn) is a leading cause of community-acquired pneumonia (CAP), yet existing diagnostic tools remain inadequate. We aimed to evaluate laboratory and radiological methods for detecting pneumococcal aetiology in CAP patients and to estimate Spn prevalence in this group. All-aged patients hospitalized with clinically defined CAP in northern Togo were enrolled during 2010–2013. Latent class analysis pooled results of semi-automated blood culture (SABC), whole bloodlytAreal-time polymerase chain reaction (rt-PCR), serum C-reactive protein (CRP), and chest radiography

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31

Roy, S., S. Russo, G. Black, et al. "Upregulation of thymidine phosphorylase (TP) by radiation (XRT): Phase II study of capecitabine (CAP) with XRT in pts with locally advanced (LA) pancreatic cancer." Journal of Clinical Oncology 24, no. 18_suppl (2006): 14001. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.14001.

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14001 Background: Preliminary studies have shown that XRT unregulates TP, the main enzyme responsible for activity of CAP. The objectives of this phase II study were to further evaluate effect of XRT on TP, DPD, and TNF-alpha as well as response and efficacy of CAP with concurrent XRT in pts with LA pancreatic cancer. Methods: Pts received 50.4 Gy XRT with CAP at 1600 mg/m2 M-F × 6 wks determined from our phase I study (JCO, Dec 2005). Following CAP-XRT, stable and responding pts on CT scan were treated with CAP 2000mg/m2 × 14 days q 3 wks till progression. Restaging was performed every 9 wks.

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32

Shtepa, Olha. "INFLUENCE OF CONCOMITANT ARTERIAL HYPERTENSION ON ACTIVITY OF INFLAMMATORY PROCESS IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA." EUREKA: Health Sciences 2 (March 30, 2018): 44–50. http://dx.doi.org/10.21303/2504-5679.2018.00614.

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The aim of the work was to determine the diagnostic value of the markers of surfactant protein D (SP-D) and C-reactive protein (C-RP) in patients with community-acquired pneumonia (CAP) with concomitant arterial hypertension (AH) and its effects on the activity of the inflammatory process. The study included 79 people. Among them, 63 patients with CAP and 16 healthy individuals who were a control group. Depending on the presence of hypertension, the patients were divided into two groups. The first group included 26 patients with CAP with AH, the second – 37 patients with CAP without AH. All pa

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33

Peyvandi, Flora, and Christian Duby. "Caplacizumab, Anti-Vwf Nanobody Potentially Changing the Treatment Paradigm in Thrombotic Thrombocytopenic Purpura: Results of the TITAN Trial." Blood 124, no. 21 (2014): 229. http://dx.doi.org/10.1182/blood.v124.21.229.229.

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Abstract INTRODUCTION: The TITAN trial achieved its primary endpoint in the ITT analysis of 75 subjects treated either with caplacizumab or placebo added to daily plasma exchange (PE). METHODS: Caplacizumab is a Nanobody which binds the A1 domain of vWF and thereby blocks the interaction of multimeric vWF with the GPIb-IX-V platelet receptor, preventing platelet aggregation typical of TTP. TITAN was a randomized, placebo controlled, single-blind, parallel design study. The primary endpoint was time to confirmed platelet response defined as platelet count normalization confirmed 48 hours later.

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Wetzel, Kyle K. "Utility Scale Twist-Flap Coupled Blade Design." Journal of Solar Energy Engineering 127, no. 4 (2005): 529–37. http://dx.doi.org/10.1115/1.2037089.

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This paper reports an investigation of the use of off-axis carbon fibers in the all-carbon spar cap of a 37-m wind turbine rotor blade to induce twist-flap coupling. Many studies have been published on the structure of wind turbine rotor blades incorporating off-axis fibers; none has studied optimizing the blade structure simultaneously considering the angle of off-axis material, the fraction of off-axis material, constraints on cross-fiber and in-plane shear strength, constraints on tip deflection, and blade cost. A parametric study has been conducted varying the angle of off-axis fibers from

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Vukelja, S., D. Richards, L. T. Campos, et al. "Randomized phase II study of perifosine in combination with capecitabine versus capecitabine alone in patients with second- or third-line metastatic colon cancer." Journal of Clinical Oncology 27, no. 15_suppl (2009): 4081. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.4081.

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4081 Background: Perifosine (Peri), a synthetic alkylphospholipid, inhibits or modifies a number of different signal transduction pathways (AKT, MAPK and JNK). Peri as a single agent or in combination with other cytotoxic agents, has shown clinical benefit with a manageable safety profile. In a phase I solid tumor trial, Peri was safely combined with capecitabine (Cap) and demonstrated interesting activity in patients (pts) with metastatic colorectal cancer (mCRC), with one patient progression-free for 49 weeks (wks). To assess the true effect of Peri, a phase II was initiated as an explorator

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Richman, Erin L., Vivian K. Weinberg, Eduardo V. Sosa, et al. "Genetic variants in antioxidant genes, Gleason grade, and prostate cancer recurrence after radical prostatectomy." Journal of Clinical Oncology 30, no. 5_suppl (2012): 33. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.33.

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33 Background: Laboratory and genomic data suggest that the antioxidant defense system is important in prostate carcinogenesis, and that this relation may vary by plasma antioxidant status. Methods: Among 567 radical prostatectomy (RP) patients with non-metastatic prostate cancer (CaP), we examined genetic variants in SOD1(5 SNPs), SOD2(6), SOD3(6), TXRND1(5), TXRND2(21), GPX1(3), GPX3(8), GPX4(5), CAT(9), XRCC1(2), SELENBP1(5), SEP15(4), SEPP1(4), SEC14L2(8), and TTPA(4) and risk of high pathologic Gleason sum (8+ or 7 with primary 4+) using logistic regression, and CaP recurrence (PSA rise,

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Liu, R., H. Lühr, and S. Y. Ma. "Storm-time related mass density anomalies in the polar cap as observed by CHAMP." Annales Geophysicae 28, no. 1 (2010): 165–80. http://dx.doi.org/10.5194/angeo-28-165-2010.

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Abstract. Strong and localized thermospheric mass density events are observed in the polar cap region by the CHAMP satellites at about 400 km altitude during geomagnetic storms. During the 4 years considered (2002–2005) 29 storms with Dst<−100 nT occurred, in 90% of them polar cap density anomalies were detected. Based on the altogether 56 anomaly events a statistical analysis was performed. The anomalies are of medium scale (500–1500 km) and seem to have a short dwell-time (<1.5 h) in the polar cap. The relative density enhancement is found to range around 2 in both hemispheres. The pea

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Lorenzen, Sylvie, Jorge Riera-Knorrenschild, Georg Martin Haag, et al. "Lapatinib versus lapatinib plus capecitabine as second-line treatment in HER-2-overexpressing metastatic gastro-esophageal cancer (GC): A randomized phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)." Journal of Clinical Oncology 33, no. 3_suppl (2015): 112. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.112.

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112 Background: HER2 amplification is present in a subgroup of gastroesophageal cancers (GCs). HER2 inhibition with trastuzumab has shown to improve outcomes in advanced disease. Lapatinib ditosylate (LAP), a dual anti-EGFR and anti-HER2 tyrosine kinase inhibitor with preclinical activity against GC, has been approved in HER2-positive breast cancer. We aimed to study the activity of LAP in HER2-amplified GC. Methods: Patients (pts) with HER2-positive (gene amplification or increased copy numbers based on predefined criteria) advanced GC were randomly allocated 1:1 to receive LAP 1250 mg per da

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ELEMRAID, M. A., S. P. RUSHTON, M. D. F. SHIRLEY, et al. "Impact of the 7-valent pneumococcal conjugate vaccine on the incidence of childhood pneumonia." Epidemiology and Infection 141, no. 8 (2012): 1697–704. http://dx.doi.org/10.1017/s0950268812002257.

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SUMMARYIn September 2006, the 7-valent pneumococcal conjugate vaccine (PCV7) was added to the UK immunization programme. We aimed to evaluate the impact of PCV7 on the incidence of all-cause community-acquired pneumonia (CAP) in children. A prospective survey was undertaken in 2008–2009 at 11 hospitals in North East England of children aged 0–16 years with radiologically confirmed pneumonia. Data were compared to those from a similar survey undertaken in the same hospitals in 2001–2002. A total of 542 children were enrolled, of which 74% were aged <5 years. PCV7 uptake was 90·7%. The incide

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Leighl, Natasha B., Natasha Rekhtman, William A. Biermann, et al. "Molecular Testing for Selection of Patients With Lung Cancer for Epidermal Growth Factor Receptor and Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitors: American Society of Clinical Oncology Endorsement of the College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology Guideline." Journal of Clinical Oncology 32, no. 32 (2014): 3673–79. http://dx.doi.org/10.1200/jco.2014.57.3055.

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Purpose The College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) guideline on molecular testing for the selection of patients with lung cancer for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors was considered for endorsement. Methods American Society of Clinical Oncology (ASCO) staff reviewed the CAP/IASLC/AMP guideline for developmental rigor; an ASCO ad hoc review panel of experts reviewed the guideline content. Results The ASCO pan

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Al-Hosiny, N. M., A. A. El-Maaref, and R. M. El-Agmy. "Mitigation of Thermal Effects in End Pumping of Nd : YAG and Composite YAG/Nd : YAG Laser Crystas, Modelling and Experiments-=SUP=-1-=/SUP=-." Журнал технической физики 91, no. 8 (2021): 1268. http://dx.doi.org/10.21883/jtf.2021.08.51103.38-21.

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In this work, we have presented a finite element (FE) numerical modelling simulations to study and analyze the thermal effects in Nd : YAG and composite YAG/Nd : YAG laser rods. We have calculated the temperature distributions, stress intensity and thermal focal lengths at different pump powers for both rods. The FE simulations showed that using composite laser rod of undoped cap reduces the maximum value of stress intensity and thermal focal length by &#126;35&#37; and &#126; 50&#37;, respectively. We have verified the FE calculations experimentally by direct measurement of fo

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PULJIZ, I., I. KUZMAN, O. DAKOVIC-RODE, N. SCHÖNWALD, and B. MISE. "Chlamydia pneumoniae and Mycoplasma pneumoniae pneumonia: comparison of clinical, epidemiological characteristics and laboratory profiles." Epidemiology and Infection 134, no. 3 (2005): 548–55. http://dx.doi.org/10.1017/s0950268805005522.

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The purpose of our retrospective 3-year study was to analyse and compare clinical and epidemiological characteristics in hospitalized patients older than 6 years with community-acquired pneumonia (CAP) caused by Chlamydia pneumoniae (87 patients) and Mycoplasma pneumoniae (147 patients). C. pneumoniae and M. pneumoniae infection was confirmed by serology. C. pneumoniae patients were older (42·12 vs. 24·64 years), and were less likely to have a cough, rhinitis, and hoarseness (P<0·001). C. pneumoniae patients had higher levels of C-reactive protein (CRP), and aspartate aminotransferase (AST)

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Hettich, Schierjott, Epple, et al. "Calcium Phosphate Bone Graft Substitutes with High Mechanical Load Capacity and High Degree of Interconnecting Porosity." Materials 12, no. 21 (2019): 3471. http://dx.doi.org/10.3390/ma12213471.

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Bone graft substitutes in orthopedic applications have to fulfill various demanding requirements. Most calcium phosphate (CaP) bone graft substitutes are highly porous to achieve bone regeneration, but typically lack mechanical stability. This study presents a novel approach, in which a scaffold structure with appropriate properties for bone regeneration emerges from the space between specifically shaped granules. The granule types were tetrapods (TEPO) and pyramids (PYRA), which were compared to porous CaP granules (CALC) and morselized bone chips (BC). Bulk materials of the granules were mec

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Salkind, Alan R., Paul G. Cuddy, and John W. Foxworth. "Fluoroquinolone Treatment of Community-Acquired Pneumonia: A Meta-Analysis." Annals of Pharmacotherapy 36, no. 12 (2002): 1938–43. http://dx.doi.org/10.1345/aph.1c167.

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OBJECTIVE: To determine the role of newer fluoroquinolones (FQs) for adults with community-acquired pneumonia (CAP) whose level of illness allows treatment with an oral antibiotic. METHODS: Meta-analysis of randomized controlled trials comparing a macrolide, β-lactam, or doxycycline antibiotic with a newer oral FQ for the treatment of CAP. RESULTS: Patients (5118), most of whom were <60 years of age and free of coexisting diseases, were enrolled in 13 studies comparing an oral macrolide or β-lactam antibiotic with an FQ for the treatment of CAP. No previous study compared doxycycline with a

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Chen, Y. R., Y. F. Huang, and W. S. Chen. "Localization of acid phosphatases in root cap of rice plant." Proceedings, annual meeting, Electron Microscopy Society of America 49 (August 1991): 224–25. http://dx.doi.org/10.1017/s0424820100085423.

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Acid phosphatases are widely distributed in different tisssues of various plants. Studies on subcellular localization of acid phosphatases show they might be present in cell wall, plasma lemma, mitochondria, plastid, vacuole and nucleus. However, their localization in rice cell varies with developmental stages of cells and plant tissues. In present study, acid phosphatases occurring in root cap are examined.Sliced root tips of ten-day-old rice(Oryza sativa) seedlings were fixed in 0.1M cacodylate buffer containing 2.5% glutaraldehyde for 2h, washed overnight in same buffer solution, incubated

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Bontsevich, Roman, Tatiana Filinichenko, Anna Gavrilova, et al. "Assessment of physicians’ and senior medical students’ knowledge in treatment of patients with community-acquired pneumonia: Current results of the KNOCAP project." Research Results in Pharmacology 4, no. 3 (2018): 27–36. http://dx.doi.org/10.3897/rrpharmacology.4.29454.

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Introduction. Community-acquired pneumonia (CAP) remains one of the most acute problems of bronchopulmonary pathology being the 4th in the mortality structure (after cardiovascular, cerebrovascular diseases and malignant neoplasms) and the 1st among all fatalities from infectious diseases. Thanks to the scientific progress achieved in the antibiotic therapy and vaccine prophylaxis, the death toll has decreased four times compared to its rate during the “pre-antibiotic era“. However, nowadays there is a steadily increasing trend in the pneumonia mortality rate in Russia. The only possible way t

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Sangla, Frédéric, David Legouis, Pierre-Emmanuel Marti, et al. "One year after ICU admission for severe community-acquired pneumonia of bacterial, viral or unidentified etiology. What are the outcomes?" PLOS ONE 15, no. 12 (2020): e0243762. http://dx.doi.org/10.1371/journal.pone.0243762.

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Introduction Multiplex polymerase chain reaction (mPCR) for respiratory virus testing is increasingly used in community-acquired pneumonia (CAP), however data on one-year outcome in intensive care unit (ICU) patients with reference to the causative pathogen are scarce. Materials and methods We performed a single-center retrospective study in 123 ICU patients who had undergone respiratory virus testing for CAP by mPCR and with known one-year survival status. Functional status including dyspnea (mMRC score), autonomy (ADL Katz score) and need for new home-care ventilatory support was assessed at

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Schmidt, Louise Steffensen, Guðfinna Ađalgeirsdóttir, Finnur Pálsson, Peter L. Langen, Sverrir Guđmundsson, and Helgi Björnsson. "Dynamic simulations of Vatnajökull ice cap from 1980 to 2300." Journal of Glaciology 66, no. 255 (2019): 97–112. http://dx.doi.org/10.1017/jog.2019.90.

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AbstractLike most ice caps and glaciers worldwide, Icelandic glaciers are retreating in a warming climate. Here, the evolution of Vatnajökull ice cap, Iceland, from 1980 to 2300 is simulated by forcing the Parallel Ice Sheet Model (PISM) with output from Regional Climate Models (RCMs). For climate simulations of the recent past, HARMONIE-AROME reanalysis-forced simulations are used, while for future climate conditions, high-resolution (5.5 km) simulations from the RCM HIRHAM5 are used in addition to available CORDEX simulations (12 km). The glacier evolution is modelled using the RCP 4.5 and R

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CLARK, J. E., D. HAMMAL, F. HAMPTON, D. SPENCER, and L. PARKER. "Epidemiology of community-acquired pneumonia in children seen in hospital." Epidemiology and Infection 135, no. 2 (2006): 262–69. http://dx.doi.org/10.1017/s0950268806006741.

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There is little UK data on hospital admission rates for childhood pneumonia, lobar pneumonia, severity or risk factors. From 13 hospitals serving the catchment population, demographic and clinical details were prospectively collected between 2001 and 2002 for children aged 0–15 years, seen by a paediatrician with community-acquired pneumonia (CAP) and consistent chest X-ray changes. From 750 children assessed in hospital, incidence of CAP was 14·4 (95% CI 13·4–15·4)/10000 children per year and 33·8 (95% CI 31·1–36·7) for <5-year-olds; with an incidence for admission to hospital of 12·2 (95%

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Moon, W., and K. I. Seo. "P316 Hepatobiliary manifestations measured by vibration-controlled transient elastography in inflammatory bowel disease: A prospective hospital-based cohort study." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S312. http://dx.doi.org/10.1093/ecco-jcc/jjz203.445.

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Abstract Background Intestinal mucosal injury is supposed to cause liver disease and inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) is a typical chronic injury of intestinal mucosa. Therefore, we investigated the hepatobiliary manifestation with liver ultrasonography (LUS) and vibration-controlled transient elastography (VCTE) in IBD. Methods IBD patients newly diagnosed in Kosin University Gospel Hospital were enrolled consecutively. Gross hepatobiliary abnormality was evaluated with LUS and simultaneous liver stiffness measurement (LSM) and controlled atte

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