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1

Nissbeck, Mikael. "Determining the oligomeric structure of PARN." Thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167233.

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Poly(A)-specific ribonuclease (PARN) is a deadenylase that degrades the poly(A) tail of eukaryotic mRNA. PARN also interacts with the 5’-cap structure of the mRNA. The binding of the cap structure enhances the deadenylation rate. PARN has previously been described as a dimer. We have studied PARN with size exclusion chromatography to investigate the oligomeric composition and revealed oligomeric compositions of PARN that are larger than dimeric PARN. Deadenylation assays have been used to measure the cap stimulated activity of PARN. The deadenylation assays showed that the cap stimulated activ
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2

Murnane, Owen D., Beth A. Prieve, and Evan M. Relkin. "Recovery of the Human Compound Action Potential Following Prior Stimulation." Digital Commons @ East Tennessee State University, 1998. https://dc.etsu.edu/etsu-works/1793.

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The recovery from prior stimulation of the compound action potential (CAP) was measured using a forward masking stimulus paradigm in four normal-hearing, human subjects. The CAP was recorded using a wick electrode placed on the tympanic membrane. The effects of a 4000-Hz, 97-dB SPL conditioning stimulus on CAP amplitude in response to a 4000-Hz probe were measured as a function of conditioner–probe interval for three probe levels. The normalized probe response amplitude was completely recovered to the control values at an average conditioner–probe interval of 1359 ms, similar to that observed
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3

Ladeira, Andrea. "Investigaçăo sobre o impacto da estimulaçăo transcraniana por corrente contínua em tarefa de resoluçăo temporal por meio da prova RGDT - Random Gap Detection Test." Universidade Presbiteriana Mackenzie, 2009. http://tede.mackenzie.br/jspui/handle/tede/1712.

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Made available in DSpace on 2016-03-15T19:40:38Z (GMT). No. of bitstreams: 1 Andrea Ladeira.pdf: 1035915 bytes, checksum: f76efbda2284ef8ff5e885e13e4e3d1c (MD5) Previous issue date: 2009-01-22<br>Fundo Mackenzie de Pesquisa<br>The Central Auditory Processing Disorders are the deficiency of one or more hearing processes and mechanisms or the deficiency of major dysfunctions. Considering that new therapeutic and/or diagnostic approaches should be investigated, recent studies have shown that non invasive cerebral stimulation tools are efficient in the modulation of brain activity in a safe and
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4

Bradley, Hollie. "A formative evaluation of the Ndinogona 'I can' stimulation programme." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20726.

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This dissertation reports an outcome and process evaluation of the Ndinogona ''I Can'' Stimulation Programme. The programme caters for children with disabilities by targeting Early Childhood Development (ECD) centres attended by children with disabilities. The programme facilitators provide training to the caregivers within these centres in terms of the importance of play and how to handle and position children with disabilities correctly. The centres are also provided with stimulation kits including a variety of toys and activities aimed at children with all types of disabilities. The program
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Brewington, John J. III. "Chronic ß2AR stimulation limits CFTR activation in human airway epithelia." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1624914837164001.

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6

Lai, Choi-hung, and 賴彩紅. "Beta adrenergic stimulation and intracellular cAMP levels: changes in septic shock." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B45011242.

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7

Sitmo, Mabruka S. H. "Stimulation of voltage-dependent Ca2+ channels by NO at rat myenteric ganglia." Giessen VVB Laufersweiler, 2009. http://d-nb.info/994755902/04.

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8

Crema, Matthew V. "Can the phased array stimulation strategy be implemented using the advanced bionics cochlear implant?" Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/107333.

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Thesis: S.M., Harvard-MIT Program in Health Sciences and Technology, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 179-189).<br>Cochlear implants are devices that aim to restore a measure of hearing to the deaf by converting acoustic signals to electric stimuli delivered to electrodes implanted in the inner ear. Theoretically, the phased array stimulation strategy described by van den Honert and Kelsall (2007) provides much better control over the neural excitation patters elicited by electric stimulation by taking advantage of potential field sup
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9

Dodd, Christopher H. "Toll-like receptor stimulation can lead to differential production of IL-23 and IL-12." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2009r/dodd.pdf.

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10

Sousa, Daniela Alexandra Costeira de. "Stimulation of a pDC cell line with self-DNA immune complexes." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22095.

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Mestrado em Biomedicina Molecular<br>Plasmacytoid dendritic cells (pDCs) are a subset of Dendritic Cells that when stimulated can produce pro-inflammatory mediators and type I IFNs. These cells play an important role in autoimmune disease such as systemic lupus erythematosus, as they can become activated by immune complexes formed with self-DNA, which trigger a type I IFN response through the TLR-9 signaling pathway. Here, we optimized activation of CAL-1 cells, a human pDC cell line, with immunocomplexes of self-nuclear or mitochondrial DNA with the antimicrobial peptide LL37. It was f
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11

Susser, Jessica R. "Can we reduce phosphorus runoff into Lake Erie by stimulating soil biota?" University of Toledo / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1515756009087471.

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12

Sitmo, Mabruka S. H. [Verfasser]. "Stimulation of voltage-dependent Ca2+ channels by NO at rat myenteric ganglia / eingereicht von Mabruka Sitmo." Giessen : VVB Laufersweiler, 2009. http://d-nb.info/994351399/34.

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13

Schmidt, Sebastian [Verfasser], and Florian [Akademischer Betreuer] Lang. "SGK1 und Akt abhängige Stimulation des speicherabhängigen Ca2+ - Einstroms in Tumorzellen / Sebastian Schmidt ; Betreuer: Florian Lang." Tübingen : Universitätsbibliothek Tübingen, 2016. http://d-nb.info/1163665118/34.

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14

Luo, R. "Can the voluntary drive to a paretic muscle be estimated from the myoelectric signal during stimulation?" Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1409755/.

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Patients with SCI sometimes recover lost function after using FES. This phenomenon, known as the carry-over effect, is not fully understood. One theory used to explain this mechanism is that electrical stimulation of the peripheral nerve causes antidromic action potentials to reach the anterior horn cells in time with the patient’s voluntary effort. This may reinforce the motor pathways and consequently restore voluntary control. However, the theory has never been properly tested and testing requires a method of measuring the voluntary drive. This project aims to find out whether it is possibl
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15

Vaos, Solano Maria Teresa. "CAN WE REDUCE THE ONSET AND RECIDIVISM OF CRIME WITH NON-INVASIVE BRAIN STIMULATION? A SYSTEMATIC REVIEW OF THE EFFECTS OF TRANSCRANIAL DIRECT CURRENT STIMULATION ON RESPONSE INHIBITION." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-25216.

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Deficits in executive functions, specifically in response inhibition (RI), have been reported in antisocial behavior, conduct disorder, attention-deficit/hyperactivity disorder (ADHD), etc. Individuals with deficits in RI have a high probability to show non-adapted social behavior that can lead to crime. Many studies have shown that transcranial direct current stimulation (tDCS), a noninvasive brain stimulation (NIBS) technique, modulate the activity of the prefrontal cortex and the functions involved in executive control and RI. This article aims to review the literature on the effect of tDCS
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16

Udagawa, Rie. "Blocking L-type calcium channels enhances long-term depression induced by low-frequency stimulation at hippocampal CA1 synapses." Kyoto University, 2008. http://hdl.handle.net/2433/135930.

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17

Gratwicke, J. P. "Can deep brain stimulation of the nucleus basalis of Meynert improve thinking and memory problems in Lewy body dementias?" Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1563430/.

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The Lewy body dementias, Parkinson’s disease dementia and dementia with Lewy bodies, are two of the most common causes of dementia worldwide, and share both a common clinical phenotype and underlying pathology. Despite their growing economic and societal disease burden, there are currently only a small number of limited symptomatic therapies available, while modern approaches to develop disease modifying biologic agents have so far produced little tangible effect. There is growing recognition of the need to explore alternative treatment avenues, and the success of deep brain stimulation (DBS)
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18

Gustavsson, Natalia. "Cell-Specific Ca2+ Response in Pancreatic ß-cells." Doctoral thesis, Umeå universitet, Histologi med cellbiologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-661.

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Pancreatic ß-cells are heterogeneous in their secretory responsiveness, glucose sensitivity and metabolic rate. A diminished and delayed first-phase insulin release is an early sign of failing ß-cells in diabetes. Mechanisms controlling functional characteristics, such as lag time for insulin release or magnitude of the response in each individual cell are unknown. To find out whether the heterogeneity represents a random phenomenon in ß-cell or is a manifestation of reproducible characteristics, we compared parameters of Ca2+ response in Fura-2 labelled ob/ob mouse ß-cells during two consecut
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19

Braun, Hannah-Sophie [Verfasser]. "GABA, GadX and Gut Health: How Stimulation of EPEC Transcription Factor GadX Can Improve the Gut Mucosal Barrier / Hannah-Sophie Braun." Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1190087774/34.

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20

Jantjies, Beverley Esther. "How can I create a stimulating environment to promote awareness of and love for reading in my classroom?" Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/987.

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This study critically examines my classroom practice in teaching young learners aged four-and-a-half to six years old. It focuses on the following research question: How can I create a stimulating environment in my classroom to promote awareness of and a love for reading? My classroom-based action research methodology places me, the practitioner, at the centre of the investigation. The work examines closely my professional values and my strong belief in the capacity of learners to be curious, absorb and make sense of what they encounter and experience in a stimulating environment. It investiga
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Costa, átila. "Pinçamento digital e estímulo elétrico na determinação da Concentração Anestésica Mínima (CAM) de isofluorano em galinhas prétratadas ou não com meloxicam." Universidade do Estado de Santa Catarina, 2009. http://tede.udesc.br/handle/handle/821.

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Made available in DSpace on 2016-12-08T16:24:07Z (GMT). No. of bitstreams: 1 PGCA09MA051.pdf: 896959 bytes, checksum: fead018a3cd8ddb84de936e3f798d903 (MD5) Previous issue date: 2009-11-19<br>The toe pinch has been the nociceptive stimuli in determining the minimum anesthetic concentration (MAC) in birds. In mammals electrical simulation has been used with high accuracy and repeatability. The non steroid anti-inflammatory meloxicam, has been used safely in birds, but its efficacy and safety during anesthesia, is still unknown. Thirty chickens (Gallus gallus) healthy, same batch, age 30 to 45
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22

Staples, Karl James. "Regulation of interleukin 5 and granulocyte macrophage colony stimulating factor from T cells by glucocorticoids and cAMP elevating agents." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251599.

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23

Wyeth, Charles Anthony. "The role of local industrial parks in stimulating and supporting the growth and development of small, medium and micro enterprises in the Western Cape Province." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/52018.

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Thesis (MBA)--Stellenbosch University, 2000.<br>ENGLISH ABSTRACT: Over the past few years considerable debate has taken place regarding the role of Local lndustrial Parks (LIPs) in stimulating the growth and development of Small, Medium and Micro Enterprises (SMMEs) in South Africa. LIPs are normally established to achieve specific development objectives, namely, job creation, sector specific support, entrepreneurship/small business promotion and the provision of affordable workspace. Through interviews with centre managersof each of the LIPs located in the Western Cape Province, and th
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Malebanye, Potsane. "To investigate how Mobile Cellular Network Operators can increase the average revenue per user by stimulating the usage of broadband services." Thesis, University of South Africa, 2007. http://hdl.handle.net/10500/56.

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The objective of this research is to investigate how mobile cellular network operators can increase the average revenue per user by stimulating the usage of mobile broadband services. There is a general consensus that the revenue from voice calls is slowly reaching saturation; hence, mobile cellular operators, service providers and content providers are looking for other sources of revenue from their new and existing customers. They are therefore beginning to focus more intensively on customer retention and on developing new strategies that will stimulate the usage of high speed mobile
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25

Cantereau, Anne. "Étude, par imagerie confocale de fluorescence, de la dynamique spatio-temporelle du Ca2+ libre intracellulaire et de son évolution au cours de la différenciation des cellules musculaires squelettiques de rat in vitro." Bordeaux 2, 1997. http://www.theses.fr/1997BOR28493.

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26

Rojas, Joseane Jiménez. "Enriquecimento ambiental como estratégia neuroprotetora em ratos submetidos à hipóxia-isquemia neonatal." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/143608.

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A hipóxia-isquemia (HI) é a principal causa de mortalidade no período perinatal e, nos sobreviventes, a incidência de comorbidades neurológicas é elevada. O encéfalo imaturo, altamente susceptível ao insulto hipóxico-isquêmico, é bastante sensível a estímulos ambientais tais como o enriquecimento ambiental (EA). Os objetivos deste estudo foram: 1) investigar o desempenho comportamental em um novo teste de memória e aprendizagem, o Ox-maze; 2) analisar a atividade das enzimas Na+,K+-ATPase, catalase (CAT) e glutationaperoxidase (GPx) no hipocampo; 3) caracterizar os neurônios piramidais da regi
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27

Bonnevie, Tristan. "Nouveaux outils et optimisation des outils existants pour la réhabilitation respiratoire et la ré-autonomisation des patients atteints d'un handicap ventilatoire. Chronic obstructive pulmonary disease Six-minute stepper test to set pulmonary rehabilitation intensity in patients with COPD - a retrospective study Can the six-minute stepper test be used to determine the intensity of endurance training in early stage COPD : a multicenter observational study The six-minute stepper test is related to muscle strength but cannot substitute for the one repetition maximum to prescribe strength training in patients with COPD People undertaking pulmonary rehabilitation are willing and able to provide accurate data via a remote pulse oximetry system : a multicentre observational study Mid-term effects of pulmonary rehabilitation on cognitive function in people with severe chronic obstructive pulmonary disease NIV is not adequate for high intensity endurance in COPD Home-based neuromuscular electrical stimulation as an add-on to pulmonary rehabilitation does not provide further benefits in patients with chronic obstructive pulmonary disease : a multicenter randomized trial Lumbar transcutaneous electrical nerve stimulation to improve exercise performance in COPD patients Advanced telehealth technology improves in-home pulmonary rehabilitation for people with stable chronic obstructive pulmonary disease : a systematic review Nasal high flow for stable patients with chronic obstructive pulmonary disease : a systematic review and meta-analysis." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMR024.

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La réhabilitation respiratoire (RR) est recommandée dans la prise en soin des patients atteints d’un handicap ventilatoire afin d’améliorer leur qualité de vie. Malgré une efficacité clairement établie, très peu de patients en bénéficient et les modalités optimales d’entrainement restent à définir. L’utilisation des outils existants et des nouveaux outils pour optimiser l’accès au programme et ses effets représentent des développements majeurs qui méritent d’être évalués. Dans le cadre de cette thèse, nous avons cherché à aborder ces deux problématiques (1) en tentant de proposer un modèle de
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Wolff, Toby. "Can microcurrent electrical neuromuscular stimulation decrease symptoms associated with delayed onset muscle soreness?" Thesis, 2005. http://hdl.handle.net/10125/20656.

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Lu, Cheng-Hsien, and 盧成憲. "Effects of Ca2+ channel blockers on cytosolic Ca2+ levels in neuronal cells under oxidative stimulation induced by t-butyl hydroperoxide." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/44500102090546873294.

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碩士<br>長庚大學<br>臨床醫學研究所<br>90<br>The effect of the oxidant t-butyl hydroperoxide on intracellular free levels of Ca2+ ([Ca2+]i) in PC12 pheochromocytoma cells was examined by using fura-2 as a fluorescent dye. t-Butyl hydroperoxide induced an increase in [Ca2+]i in a concentration-dependent fashion between 50-250 mM with an EC50 of 100 mM. The [Ca2+]i signal consisted of a slow rise and a sustained phase. The response was decreased by 65% by removal of extracellular Ca2+. In Ca2+-free medium, pretreatment with 1 mM thapsigargin (an endoplasmic reticulum Ca2+ pump inhibitor) abolished 150 mM t-bu
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鄭信忠. "Transition of Early-LTP into Late-LTP by Somatic theta-Burst Stimulation at CA1 Synapses in Rat Hippocampus." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/29417016612978641802.

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碩士<br>中國醫藥大學<br>醫學研究所<br>92<br>The purpose of this study to investigate the effect of somatic q-burst stimulation on expression of early phase long-term potentiation ( LTP ) induced by 1 train of tetanus stimulation comprising 100 pulses at 100 Hz, at CA1 synapses in rat hippocampus, and the underlying cellular mechanisms. Standard electrophysiological technique for field-potential recording in hippocampal slices was employed. A glass recording electrode ( filled with 3M NaCl, 3-5 MW ) was positioned in stratum rediatum, and two bipolar stainless stimulating electrodes were position
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Chen, Yea-lin, and 陳雅琳. "Time-Dependent Reversal of Long-Term Potentiation by Low-Frequency Stimulation at the Hippocampal Mossy Fiber-CA3 Synapses." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/87773335890134974441.

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碩士<br>國立成功大學<br>藥理學研究所<br>89<br>Long-term potentiation (LTP) is characterized by its rapid induction and remarkable stability. In the past few years, most studies investigated the mechanism for its rapid induction. However, it is still unclear about the mechanisms underlying the conversion of initial potentiation into a persistent state. The consolidation of LTP plays a crucial role in memory formation, so it will help us to understand the mechanism of learning and memory. Therefore, the principle purpose of this study is to explore what factors and mechanisms contribute mechanism of the mossy
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Chen, Wen-wen, and 陳雯雯. "Transplantation of Schwann Cells Plus Stimulation of Pulsed Electromagnetic Fields Can Promote Axonal Regeneration in The Damaged Rat Spinal Cord." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/79249971216643827781.

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碩士<br>國立中興大學<br>獸醫學系<br>91<br>The formation of scar and expression of inhibitors around/in the lesion area after CNS damaged are the major reasons for axonal regeneration failure [McKeon et al., 1991; Bahr et al., 1995]. In contrast provision with a supporting cell bridge can promote axonal regeneration. Schwann cells forming myelin around axons is associated with action potential in the PNS. Recent studies suggest that transplantation of Schwann cells can help axonal regeneration in the injured spinal cord of the rats [Paino et al., 1994; Harvey et al., 1995; Xu et al., 1999]. Electromagnetic
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Syu, Wei-Cheng, and 徐瑋呈. "Direct Electrical Stimulation Activates SMAD Protein Signaling through Ca2+-Calmodulin-dependent Protein Kinase II to Promote Osteogenesis of Human Dental Pulp Stem Cells." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/yha844.

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碩士<br>國立中央大學<br>化學工程與材料工程學系<br>105<br>In this study, human dental pulp stem cells (hDPSCs) were cultured on conductive polymer films which were treated direct current to explore the mechanism of electrical stimulation (ES) on the promotion of osteogenic differentiation. The results of ELISA analysis indicated that the ES did not increase BMP-2 expression. Next, a green-fluorescent tracer, Fluo-4, was applied to trace calcium ions, and the results suggested that ES increased the levels of intracellular calcium. To confirm the source of increasing calcium, different inhibitors were applied durin
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Taepavarapruk, Pornnarin. "Changes in extracellular dopamine levels in the nucleus accumbens induced by low frequency stimulation of the ventral subiculum/CA1 region of the hippocampus." Thesis, 1998. http://hdl.handle.net/2429/7731.

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The present study utilized microdialysis in freely-moving rats to investigate 1) changes in extracellular dopamine (DA) level in the nucleus accumben (NAc) induced by electrical stimulation of the ventral subiculum/CAl (Vsub/CAl) area of hippocampus, and 2) the role of metabotropic glutamate receptors (mGluRs) in mediating DA release in the NAc induced by low frequency stimulation of Vsub/CAl. It has been shown that electrical stimulation of Vsub/CAl at 2 Hz for 100 secinduces a significant decrease (p < 0.05) in basal DA levels in the NAc which is long lasting throughout the 2 hr monitori
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Winkler, Christoph-Philipp [Verfasser]. "Effekte von Verapamil auf die Expression der L-Typ-Ca2+-Kanaluntereinheiten und Phosphatasen in den frühen Phasen schneller atrialer Stimulation im Kaninchenmodell des Vorhofflimmerns / vorgelegt von Christoph-Philipp Winkler." 2007. http://d-nb.info/985141085/34.

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Shafiee-Kermani, Farideh. "Chronic gonadotropin-releasing hormone (GnRH) inhibits activin induction of the ovine follicle stimulating hormone beta-subunit (oFSH-beta) involvement of cAMP response element binding protein (CREB) and nitric oxide synthase type I (NOSI). /." 2007. http://www.lib.ncsu.edu/theses/available/etd-03192007-120126/unrestricted/etd.pdf.

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Canelas, Ana Carolina Andrade Sá. "Intervenção psicomotora na Associação para o Desenvolvimento da Criança, Integração e a Solidariedade - Nuclisol Jean Piaget de Vila Real." Master's thesis, 2020. http://hdl.handle.net/10400.5/19733.

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O presente relatório descreve as atividades de estágio desenvolvidas no âmbito do Mestrado em Reabilitação Psicomotora, Ramo de Aprofundamento de Competências Profissionais (RACP), da Faculdade de Motricidade Humana da Universidade de Lisboa, realizado na Unidade de Vila Real da Instituição Nuclisol Jean Piaget – Associação para o Desenvolvimento da Criança, a Integração e a Solidariedade. O estágio profissionalizante decorreu no ano letivo de 2017-2018, mediante uma prática de intervenção psicomotora dirigida aos clientes da referida instituição, em particular a um grupo de clientes integrado
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