Academic literature on the topic 'Capillary electrophoresis with mass spectrometry'

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Journal articles on the topic "Capillary electrophoresis with mass spectrometry"

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Smith, Richard D., Jon H. Wahl, David R. Goodlett, and Steven A. Hofstadler. "Capillary Electrophoresis/Mass Spectrometry." Analytical Chemistry 65, no. 13 (July 1993): 574A—584A. http://dx.doi.org/10.1021/ac00061a717.

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Cai, Jianyi, and Jack Henion. "Capillary electrophoresis-mass spectrometry." Journal of Chromatography A 703, no. 1-2 (June 1995): 667–92. http://dx.doi.org/10.1016/0021-9673(94)01178-h.

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Niessen, W. M. A., U. R. Tjaden, and J. van der Greef. "Capillary electrophoresis—mass spectrometry." Journal of Chromatography A 636, no. 1 (April 1993): 3–19. http://dx.doi.org/10.1016/0021-9673(93)80051-9.

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Scriba, Gerhard K. E. "Nonaqueous capillary electrophoresis–mass spectrometry." Journal of Chromatography A 1159, no. 1-2 (August 2007): 28–41. http://dx.doi.org/10.1016/j.chroma.2007.02.005.

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Buko, Alexander. "Capillary electrophoresis mass spectrometry based metabolomics." Journal of Applied Bioanalysis 3, no. 1 (March 1, 2017): 5–20. http://dx.doi.org/10.17145/jab.17.002.

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Edmonds, C. G., J. A. Loo, C. J. Barinaga, H. R. Udseth, and R. D. Smith. "Capillary electrophoresis-electrospray ionization-mass spectrometry." Journal of Chromatography A 474, no. 1 (July 1989): 21–37. http://dx.doi.org/10.1016/s0021-9673(01)93899-3.

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Ohnesorge, Jens, Christian Neusüß, and Hermann Wätzig. "Quantitation in capillary electrophoresis-mass spectrometry." ELECTROPHORESIS 26, no. 21 (November 2005): 3973–87. http://dx.doi.org/10.1002/elps.200500398.

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Klampfl, Christian W. "Special Issue: Capillary Electrophoresis-Mass Spectrometry." ELECTROPHORESIS 29, no. 10 (May 2008): 1955. http://dx.doi.org/10.1002/elps.200890041.

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Presto Elgstoen, Katja B., Jane Y. Zhao, Joseph F. Anacleto, and Egil Jellum. "Potential of capillary electrophoresis, tandem mass spectrometry and coupled capillary electrophoresis–tandem mass spectrometry as diagnostic tools." Journal of Chromatography A 914, no. 1-2 (April 2001): 265–75. http://dx.doi.org/10.1016/s0021-9673(00)01117-1.

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Vuorensola, Katariina, Heli Sirén, Risto Kostiainen, and Tapio Kotiaho. "Analysis of catecholamines by capillary electrophoresis and capillary electrophoresis–nanospray mass spectrometry." Journal of Chromatography A 979, no. 1-2 (December 2002): 179–89. http://dx.doi.org/10.1016/s0021-9673(02)01256-6.

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Dissertations / Theses on the topic "Capillary electrophoresis with mass spectrometry"

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Vuorensola, Katariina. "Capillary electrophoresis and capillary electrophoresis-mass spectrometry in catecholamine studies." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/kemia/vk/vuorensola/.

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Mironov, Gleb. "Capillary Electrophoresis - Mass Spectrometry for Bioanalysis." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33004.

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Bioanalysis is a subdivision of analytical chemistry and deals with biological analytes such as metabolites, proteins, nucleic acids, small molecules, virus particles and entire cells. The rationale of my thesis was to achieve two goals: (i) develop a set of ready to use methods (ii) which are capable providing exact concentrations of analytes as well as kinetic and thermodynamic parameters of their interactions. To investigate interactions between biomolecules special conditions are required which do not interfere with the course if biomolecule interactions. Establishing these conditions and optimization of separation and detection parameters can be tedious and can take longer than actual analysis of samples. I developed a variety of Capillary Electrophoresis – Mass Spectrometry (CE-MS) methods suitable for bionalalysis. CE-MS establishes a new paradigm that separation methods together with MS detection can be used as comprehensive kinetic tools. Most previous attempts to use chromatography and electrophoresis for studying nucleic acid interactions were restricted to assuming slow or no equilibrium between reactants. Kinetic CE (KCE) shows that non-zero kinetics and structural dynamics must be taken into account when separation happens. KCE-MS could be a valuable supplement to IM-MS due to the separation of ions in solution according to their size-to-charge ratio. These methods allowed to reveal new facts about biomolecules and added novel data to the bank of the mankind knowledge. For the best of my knowledge, kinetic parameters for TG2 and thrombin G-quadruplex folding were reported for the first time. I developed a homogeneous method to determine kon, koff and Kd of fast and weak noncovalent interactions between multiple unlabeled ligands (small molecule drugs) and an oligosaccharide (α- or β-cyclodextrin) simultaneously in one capillary microreactor. It has been shown for the first time that KCE can be used to separate and detect the slowly interconverting open and closed conformations of human TG2. It allowed the first direct measurement of the Kd value for calcium binding. Sixteen new substrates were discovered for three aminotransferases (AAT, BCAT, and DAAT). In addition, Viral qCE showed a feasibility to analyse both the count of intact viral particles and sample nucleic acid contamination.
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Goodwin, Lee. "Capillary electrophoresis-mass spectrometry and tandem mass spectrometry studies of ionic agrochemicals." Thesis, University of York, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398906.

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Palmer, Martin. "Development and application of capillary electrophoresis/mass spectrometry." Thesis, Sheffield Hallam University, 2000. http://shura.shu.ac.uk/20181/.

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Capillary electrophoresis is a generic term used to describe separation techniques employing high voltages. In its simplest form, capillary zone electrophoresis (CZE), separations are based on the differential migration of charged analytes under the influence of a high electric field. CZE offers several advantages over other separation techniques, such as high performance liquid chromatography (HPLC). These include higher separation efficiency, enhanced resolution and reduced analysis time. In addition, small injection volumes (nanolitres cf. microlitres for HPLC) and low solvent consumption make CZE an attractive alternative to HPLC. Unfortunately, CZE is not amenable to neutral species, therefore alternative electroseparation methods are employed for neutrals, e.g. capillary electrochromatography (CEC) and micellar electrokinetic chromatography (MEKC), so therefore CZE can be treated as a complementary technique to HPLC.Mass spectrometry (MS) has previously been demonstrated to be a sensitive, selective and near-universal detector. Analytes must be ionised in order to be detected; thus, CZE (which also requires ions) seems an ideal separation technique for combining with MS.CZE/MS interfacing would seem problematic; the linear flow velocity through the capillary is significantly less than that required by appropriate MS ionisation sources (e.g. continuous-flow fast atom bombardment and electrospray). In addition, it is necessary to provide a ground for the separation voltage within the interface. However, interfacing of CZE and MS was first reported in 1987. Since then three distinct interface designs have been developed, co-axial sheath flow, liquid junction and the use of a low flow electrospray (nanospray) interface. Co-axial sheath flow and liquid junction methods serve to increase the overall flow rate of CZE to a suitable level for MS, whereas nanospray is a low flow ionisation technique that accepts similar flow rates to those provided by CZE.The work presented in this thesis details the off-line development of a CZE separation of a pharmaceutical product (cimetidine) and related impurities. The separation was then transferred to mass spectral detection on a commercial triple quadrupole MS instrument employing home-built co-axial sheath flow (electrospray) and nanospray interfaces and the data obtained evaluated. The separation was subsequently transferred to an orthogonal acceleration time-of-flight MS (oa-ToF) for the exact mass determination of the narrow electrophoretic peaks. The feasibility of hydrogen/deuterium exchange via the sheath liquid for CZE/MS has been investigated using model pharmaceutical compounds and preliminary work is presented. An application of CZE/MS for the separation of nicotine and ten of its metabolites has been developed. This method could be further developed into a quantitative assay for nicotine metabolites in biological fluids and suggestions for future work in this area are made.
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Soliman, Laiel. "Capillary electrophoresis-mass spectrometry separation of isomeric biological compounds." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43419.

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Current prostate cancer (PCa) diagnosis based on prostate-specific antigen (PSA) has been gradually losing its credibility over the last decade due to contradictory results in published literature and clinical practice. Recently, a group of potential PCa biomarkers in urine, particularly sarcosine, was found to increase significantly as the cancer progressed to metastasis. In Chapter 2, we report a simple, robust, and reproducible capillary electrophoresis–electrospray ionization–tandem mass spectrometry (CE–ESI-MS/MS) method for the determination of sarcosine and other representative potential biomarkers in pooled urine. A solid phase extraction (SPE) technique was optimized for maximum recovery of sarcosine. With no derivatization step, excellent resolution between sarcosine and its isomers (α-alanine and β-alanine) was achieved. A separate non-SPE method was also developed for quantitative determination of highly concentrated urinary metabolites. Precision for intra- and inter-day standard addition calibration of sarcosine were found to be within 15%, whereas intra-day precisions for the rest of the metabolites varied from 0.03 to 13.4%. Acceptable intra-day and inter-day accuracies, ranging from 80 to 124%, were obtained for sarcosine and the other metabolites. The second part of the thesis takes on a more challenging task. The importance of chiral separation in pharmaceutical, agriculture, and food industries has driven separation scientists to develop more powerful methodologies in conjunction with the structural capabilities of mass spectrometry. In Chapter 3, chiral separation of D- and L-tryptophan was compared on a bare-fused silica capillary and a PEI-coated capillary. Although a higher resolution was observed for uncoated capillaries, analytes were found to migrate slower resulting to longer analysis times (tm > 20 min). With shorter migration times (tm < 10 min) and acceptable resolution, further investigations on different factors that could affect enantioseparation were conducted on a coated capillary. Highly-sulfated cyclodextrins (HS-CDs), a group of charged CD derivatives, were also utilized for the separation of several racemic amino acids. Resolution with HS-CDs was found to be superior to using native CDs. Unfortunately, due to time constraint, no MS work was presented as the chiral CE/MS work is still currently in progress.
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Liu, Chun-Sheng. "Development and application of capillary electrophoresis-electrospray mass spectrometry." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60321.pdf.

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Keski-Hynnilä, Helena. "Liquid chromatography - and capillary electrophoresis - mass spectrometry in glucuronide analysis." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/farma/vk/keski-hynnila/.

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Eastwood, Catherine Rachel. "The development of capillary isotachophoresis for use with electrospray mass spectrometry." Thesis, University of Huddersfield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327143.

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Baynham, Michael Thomas. "Microcolumn separations coupled to mass spectrometry : suitability for drug metabolism studies." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342000.

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Bateman, Kevin Patrick. "Sensitivity enhancement for capillary zone electrophoresis-mass spectrometry, developments and applications." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq24731.pdf.

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Books on the topic "Capillary electrophoresis with mass spectrometry"

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Xia, James Q., and Lichao Zhang, eds. Capillary Electrophoresis-Mass Spectrometry. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46240-0.

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Ramautar, Rawi, ed. Capillary Electrophoresis–Mass Spectrometry for Metabolomics. Cambridge: Royal Society of Chemistry, 2018. http://dx.doi.org/10.1039/9781788012737.

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de Jong, Gerhardus, ed. Capillary Electrophoresis-Mass Spectrometry (CE-MS): Principles and Applications. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2016. http://dx.doi.org/10.1002/9783527693801.

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service), SpringerLink (Online, ed. Capillary Electrophoresis of Carbohydrates: From Monosaccharides to Complex Polysaccharides. Totowa, NJ: Springer Science+Business Media, LLC, 2011.

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Wieland, Katrin. Bestimmung der Nicotinverteilung und anderer Stickstoffverbindungen in den Blattgeweben von Nicotiana tabacum unter verschiedenen Wachstumsbedingungen durch Einzelzellanalyse, Kapillarelektrophorese und der Massenspektrometrie. Jülich: Forschungszentrum Jülich, Zentralbibliothek, 2006.

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Cai, Jianyi. Qualitative and quantitative liquid chromatography and capillary electrophoresis/tandem mass spectrometry for drug metabolism studies and ultra trace analysis. [Ithaca, N.Y.]: [s.n.], 1996.

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Yancey, M. F. Capillary column GC-MS determination of 77 purgeable organic compounds in two simulated liquid wastes. Cincinnati, OH: U.S. Environmental Protection Agency, Environmental Monitoring and Support Laboratory, 1988.

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Yancey, M. F. Capillary column GC-MS determination of 77 purgeable organic compounds in two simulated liquid wastes. Cincinnati, OH: U.S. Environmental Protection Agency, Environmental Monitoring and Support Laboratory, 1988.

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Yancey, M. F. Capillary column GC-MS determination of 77 purgeable organic compounds in two simulated liquid wastes. Cincinnati, OH: U.S. Environmental Protection Agency, Environmental Monitoring and Support Laboratory, 1988.

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Yancey, M. F. Capillary column GC-MS determination of 77 purgeable organic compounds in two simulated liquid wastes. Cincinnati, OH: U.S. Environmental Protection Agency, Environmental Monitoring and Support Laboratory, 1988.

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Book chapters on the topic "Capillary electrophoresis with mass spectrometry"

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Klampfl, Christian W., and Markus Himmelsbach. "Nonaqueous Capillary Electrophoresis Mass Spectrometry." In Capillary Electrophoresis, 111–30. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6403-1_7.

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Michalke, Bernhard. "Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry." In Capillary Electrophoresis, 167–80. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6403-1_10.

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Wakayama, Masataka, Akiyoshi Hirayama, and Tomoyoshi Soga. "Capillary Electrophoresis-Mass Spectrometry." In Methods in Molecular Biology, 113–22. New York, NY: Springer New York, 2015. http://dx.doi.org/10.1007/978-1-4939-2377-9_9.

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Han, Mei, Brooke M. Rock, Josh T. Pearson, Yunan Wang, and Dan A. Rock. "Therapeutic Monoclonal Antibody Intact Mass Analysis by Capillary Electrophoresis–Mass Spectrometry." In Capillary Electrophoresis-Mass Spectrometry, 13–34. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46240-0_3.

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Xia, James Q. "Introduction to Capillary Electrophoresis–Mass Spectrometry." In Capillary Electrophoresis-Mass Spectrometry, 1–6. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46240-0_1.

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Xia, James Q. "Coated Capillaries for CE-MS of Therapeutic Protein." In Capillary Electrophoresis-Mass Spectrometry, 7–11. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46240-0_2.

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Wang, Weihan. "Antibody Post-translational Modifications Analysis Using CE-MS." In Capillary Electrophoresis-Mass Spectrometry, 43–51. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46240-0_6.

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Wang, Weihan. "Characterization of Intact Therapeutics and Protein Subunits Using CE-MS Platform." In Capillary Electrophoresis-Mass Spectrometry, 53–72. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46240-0_7.

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Xia, James Q. "Separation and Characterization of Proteins and Peptides in Biological Fluids Using CE-MS." In Capillary Electrophoresis-Mass Spectrometry, 35–38. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46240-0_4.

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Zhang, Lichao. "Host Cell Protein Analysis Using CE-MS." In Capillary Electrophoresis-Mass Spectrometry, 39–42. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-46240-0_5.

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Conference papers on the topic "Capillary electrophoresis with mass spectrometry"

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Lewis, Sam, John Storey, Raynella Connatser, Scott Curran, and Melanie Moses-DeBusk. "Detection of Polar Compounds Condensed on Particulate Matter Using Capillary Electrophoresis-Mass Spectrometry." In WCX SAE World Congress Experience. 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 2020. http://dx.doi.org/10.4271/2020-01-0395.

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Kim, Min-Su, Hwang-soo Joo, Byung-Gee Kim, Yong-Kweon Kim, and Hoseong Kim. "A microfabricated device with integrated nanoelectrospray source for capillary electrophoresis and mass spectrometry." In Microelectronics, MEMS, and Nanotechnology, edited by Dan V. Nicolau. SPIE, 2005. http://dx.doi.org/10.1117/12.638735.

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Lin, Che-Wei, and Che-Hsin Lin. "Capillary electrophoresis and electrospray ionization on a single-thread microfluidic system for rapid mass spectrometry detection." In 2016 IEEE 29th International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2016. http://dx.doi.org/10.1109/memsys.2016.7421667.

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Tada, Motohisa, Akiyoshi Hirayama, Fumihiko Kanai, Hideyuki Yoshitomi, Masayuki Ohtsuka, Masaru Miyazaki, Tomoyoshi Soga, and Osamu Yokosuka. "Abstract 2511: Comprehensive metabolic profiling of hepatocellular carcinoma and pancreatic tumors by capillary electrophoresis-mass spectrometry." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2511.

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Artamonova, Svetlana Yu, Vladislav E. Ushnitskii, Dmitrii Yu Troitsky, Olga V. Shuvaeva, and Evgeniya V. Polyakova. "Chemical composition of surface water of the “Crystal” site and uranium content in it in 2019." In Недропользование. Горное дело. Направления и технологии поиска, разведки и разработки месторождений полезных ископаемых. Экономика. Геоэкология. Федеральное государственное бюджетное учреждение науки Институт нефтегазовой геологии и геофизики им. А.А. Трофимука Сибирского отделения Российской академии наук, 2020. http://dx.doi.org/10.18303/b978-5-4262-0102-6-2020-030.

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The chemical composition of surface and ground water of the site of the underground nuclear explosion “Crystal” in 2019 is discussed. Methods of atomic emission spectrometry, titrimetry and capillary electrophoresis are used in the work. The content of uranium is determined by mass–spectrometry on inductively coupled plasma. The direct correlation between contents of uranium and sulphates anions probably indicates of degradation of the cement filling of the emplacement hole.
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Buko, Alexander, Leo Cheng, Andrew Gustev, and Adam Feldman. "Abstract 3510: The metabolomic profile of urine from prostate cancer patients using capillary electrophoresis mass spectrometry (CEMS)." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-3510.

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Baglan, N. "Interface Development for Coupling Capillary Electrophoresis (CE) and Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Application to Plutonium Speciation." In PLUTONIUM FUTURES - THE SCIENCE: Third Topical Conference on Plutonium and Actinides. AIP, 2003. http://dx.doi.org/10.1063/1.1594676.

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Guo, Zhongxian, Qiantao Cai, and Zhaoguang Yang. "Determination of Water-Soluble Organophosphorus Herbicides by Ion Chromatography With Inductively Coupled Plasma Mass Spectrometry Detection." In 1st Water Quality, Drought, Human Health and Engineering Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/water2006-20024.

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There is a high risk for human exposure to organophosphorus pesticides through contaminated drinking water. Glyphosate, glufosinate, fosamine and ethephon are among the water-soluble herbicides used currently. Sensitive and rapid analytical methodologies are critical for evaluating their residuals in a broad variety of samples, including environmental waters. However, challenges arise from the inherent chemical properties of the herbicides: strong polarity, high solubility in water, insolubility in organic solvent (except ethephon), absence of chromophore or fluorophore in their molecular structures. So far very rare analytical methods are available for ethephon [1] and fosamine [2], while glyphosate and glufosinate are often determined by gas chromatography [3], high performance liquid chromatography (HPLC) [4] and capillary electrophoresis (CE) [5]. Inductively coupled plasma mass spectrometry (ICP-MS) is sensitive, rapid, selective, and is more powerful when hyphenated with appropriate separation. For the analysis of glufosinate, glyphosate and its metabolite aminomethylphosphonic acid (AMPA), ICP-MS was recently coupled to CE [6] or ion-pairing reversed-phase LC [7].
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Li, Po-Hui, and Che-hsin Lin. "Gold(Working), Platinum (Counter) and Silver(Reference)Novel Lego®-Concepted Microfluidic Chip for Capillary Electrophoresis Separation, Electrochemical and Mass Spectrometry Detections." In 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems & Eurosensors XXXIII (TRANSDUCERS & EUROSENSORS XXXIII). IEEE, 2019. http://dx.doi.org/10.1109/transducers.2019.8808587.

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Li, Jianjun, Adele Martin, Valerie Bouchet, Elke K. H. Schweda, Derek W. Hood, Stephen Pelton, Richard Goldstein, Derek E. Richard Moxon, and James C. Richards. "SIALYLATED LIPOPOLYSACCHARIDE GLUCOFORMS ARE CRITICAL VIRULENCE DETERMINANTS IN HAEMOPHILUS INFLUENZAE OTITIS MEDIA: ANALYSIS OF MIDDLE EAR WASHINGS FROM INFECTED CHINCHILLAS BY CAPILLARY ELECTROPHORESIS MASS SPECTROMETRY." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.402.

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Reports on the topic "Capillary electrophoresis with mass spectrometry"

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Fung, N. DNA sequencing with capillary electrophoresis and single cell analysis with mass spectrometry. Office of Scientific and Technical Information (OSTI), March 1998. http://dx.doi.org/10.2172/348902.

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Sepaniak, M. J., and K. D. Cook. Capillary liquid chromatography using laser-based and mass spectrometric detection. [Capillary zone electrophoresis (CZE); micellar electrokinetic capillary kchromatography (MECC)]. Office of Scientific and Technical Information (OSTI), January 1992. http://dx.doi.org/10.2172/6977773.

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Morgan, Stephen L., and Alvin Fox. Chemotaxonomic Characterization of Microorganisms by Capillary Gas Chromatography-Mass Spectrometry. Fort Belvoir, VA: Defense Technical Information Center, June 1988. http://dx.doi.org/10.21236/ada198251.

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Zhang, Hui. Developments and Applications of Electrophoresis and Small Molecule Laser Desorption Ionization Mass Spectrometry. Office of Scientific and Technical Information (OSTI), January 2007. http://dx.doi.org/10.2172/933124.

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Methods of analysis by the U.S. Geological Survey National Water Quality Laboratory--Determination of wastewater compounds by polystyrene-divinylbenzene solid-phase extraction and capillary-column gas chromatography/mass spectrometry. US Geological Survey, 2002. http://dx.doi.org/10.3133/wri20014186.

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