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Journal articles on the topic 'Capsule Dosage Form'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Babita Himmatrao More, Vaibahavi Pradeep Shirke, Aditya Sanjeev Bhambure, and Rupali Rajesh Tasgaonkar. "Duocapsule and alternative shell material to gelatin: Advancement in capsule formulation." World Journal of Biology Pharmacy and Health Sciences 13, no. 2 (2023): 221–27. http://dx.doi.org/10.30574/wjbphs.2023.13.2.0076.

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Owing to broad advantages like self-medication, unit dosage form, and patient compliance, cost effective, limited interaction with the excipients and possibility of mask the unpleasant taste, capsules are the most extensively recognized conventional solid dosage form after Tablet. In the world of Novel drug delivery system to overcome the disadvantages of conventional delivery system modifications are made in the capsule to develop a product of higher selectivity for medical treatment like the capsules that facilitates the controlled drug delivery, sustained and targeted release profiles with

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Babita, Himmatrao More, Pradeep Shirke Vaibahavi, Sanjeev Bhambure Aditya, and Rajesh Tasgaonkar Rupali. "Duocapsule and alternative shell material to gelatin: Advancement in capsule formulation." World Journal of Biology Pharmacy and Health Sciences 13, no. 2 (2023): 221–27. https://doi.org/10.5281/zenodo.8026808.

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Owing to broad advantages like self-medication, unit dosage form, and patient compliance, cost effective, limited interaction with the excipients and possibility of mask the unpleasant taste, capsules are the most extensively recognized conventional solid dosage form after Tablet. In the world of Novel drug delivery system to overcome the disadvantages of conventional delivery system modifications are made in the capsule to develop a product of higher selectivity for medical treatment like the capsules that facilitates the controlled drug delivery, sustained and targeted release profiles with

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3

Sonar, Shivani, Sheetal Gondkar, and Ravindranath B. Saudagar. "Liquid Filled Hard Gelatin Capsule." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 832–35. http://dx.doi.org/10.22270/jddt.v9i3-s.2794.

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Novel dosage forms emerges more and more in recent years. One of them is liquid-filled hard gelatin capsules, which have gelatin or the hydroxypropyl methyl cellulose (HPMC) as capsule shell. The liquid-filled hard gelatin capsule is gradually getting attention because of its new-concept dosage form design, which bring liquid drugs by solid form. The paper mostly presents application, pharmaceutical manufacturing, quality assessment, vision of liquid-filled hard gelatin capsules and emphases on the application and pharmaceutical manufacturing of liquid-filled capsule. It is recommended that th

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Pervaiz, Fahad, Sana Ali Zahra, Fariah Qaiser, Syeda Komal Fatima, and Rabbia Mazhar Khan. "Characterization and Evaluation of Capsules and Study of QC tests for Capsules." Global Pharmaceutical Sciences Review III, no. I (2018): 7–18. http://dx.doi.org/10.31703/gpsr.2018(iii-i).02.

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Using the capsule as a dosage form dates back to the early pharmacy days; from those days, the capsule preparation process is greatly evolved in order to meet the current needs of patients and the pharmaceutical industry. Currently, all pharmaceutical industries are making a dynamic change in the specifications of particular dosage forms such as capsules. It has become more difficult to obtain the higher valued drug product from the dosage form, along with the potential for improved delivery that can improve clinical outcomes. In addition, the capsules have played a significant role in drug de

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S.G.Gavande, R.O.Sonwane A.D.Pichkewar S.S.Dorik. "REVIEW ON IMMEDIATE RELEASE DOSAGE FORM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 04 (2019): 8509–18. https://doi.org/10.5281/zenodo.2652693.

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<em>Most popular immediate release dosage forms such as tablet, capsule and pellet.</em><em> Because of its convenience of self-administration, and simple to the manufacturing. The type of dosage from is some advantages such as improved stability of formulation. Improved bioavablity of Product. Rapid onset action and cost effective as compare to other dosage formulation. They disintegrant are selected as type of dosage and physical characteristics of drugs. </em><em>The basic approach used in development tablets, capsule and pellet as the use of some excipient like superdisintegrants, Bulking

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Semchenko, K. V., and L. I. Vyshnevska. "Methodological approaches to the development of the capsules «Phytohelmin» composition." Farmatsevtychnyi zhurnal, no. 6 (December 9, 2020): 78–85. http://dx.doi.org/10.32352/0367-3057.6.20.08.

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The existing range of medicines is represented by a variety of dosage forms. Among them a significant proportion takes oral solid dosage forms, in particular capsules. The introduction of active pharmaceutical ingredients in the capsule composition does not require the addition of flavouring agents and requires a significantly lower amount of excipients compared to the formation of tablet dosage forms. In the development of dosage forms based on extracts of medicinal plants, the rational choice of the dosage form is important. The use of capsules allows making a composition of several ex

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Kotov, S.A., and T.M. Gontova. "Standardization of the dosage form for the combined herbal medicine with anti-allergic activity." Annals of Mechnikov Institute, no. 4 (December 14, 2022): 42–51. https://doi.org/10.5281/zenodo.7436777.

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<strong>Introduction</strong>. The creation of a combined herbal preparation with anti-allergic action is an urgent task, it is supported by a wide base of herbal drugs for the creation of the future medicine, a wide range of biologically active substances in their original form, low toxicity and the practical absence of side effects. Such an object is the developed combined plant extract based on the composition of herbal drugs – bur-marigod herb, calendula flowers and hawthorn leaves and flowers - in a ratio of 6:3:1. <strong>The aim of the work</strong> was to standardize the dosage f

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Hussein, Ali N., Ahmed M. J. Jehan Yin, and Murtada M. Hasan. "Determination of Tetracycline in Capsule Dosage Form." International Journal of Drug Delivery Technology 10, no. 03 (2020): 465–67. http://dx.doi.org/10.25258/ijddt.10.3.28.

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Background: Tetracycline antibiotic is widely prescribed that encourages the finding of rapid and reliable protocol for the determination of tetracycline hydrochloride in hard gelatine capsules. Recently, the standard addition method is used commonly with the aid of a UV-visible (UV-vis) spectrophotometer for such purpose. In this work, the authors aim to quantify the percent assay of Apcycline-250 capsules utilizing the standard addition protocol. Methods: Twenty filled and emptied capsules were weighed and an equivalent amount of 50 mg of tetracycline hydrochloride was diluted, filtered, and

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Shah, Dimal A., Akash Patel, Sunil L. Baldania, Usmangani K. Chhalotiya, and Kashyap K. Bhatt. "Simultaneous Estimation of Pantoprazole Sodium and Levosulpiride in Capsule Dosage Form by Simultaneous Equation Spectrophotometric Method." ISRN Spectroscopy 2013 (May 9, 2013): 1–4. http://dx.doi.org/10.1155/2013/459820.

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A simple, accurate, and precise spectrophotometric method was developed for simultaneous estimation of pantoprazole sodium and levosulpiride in capsule dosage form. Simultaneous equation was developed at 290 and 232 nm. The method was found to be linear in the range of 4–12 μg/mL for pantoprazole sodium and 8–20 μg/mL for levosulpiride while accuracy of the method was confirmed by recovery studies of capsule dosage form and was found to be 100.23–100.99% and 100.51–100.94% for pantoprazole sodium and levosulpiride, respectively, in their capsule dosage form. The proposed method was validated a

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Gupta, Shallini, Kanika Khajuria, Niraj Kumar, and Vijay Khajuria. "Evaluation of capsule labelling for its wall contents as gelatin or non gelatin." International Journal of Basic & Clinical Pharmacology 7, no. 7 (2018): 1387. http://dx.doi.org/10.18203/2319-2003.ijbcp20182687.

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Background: Capsules are the most commonly used solid drug dosage form and are made up of gelatin or non gelatin. Currently the gelatin based capsules drug formulations are more used. However, current issue of vegetarian and non vegetarian capsules has come up due to recent Indian government initiative to promote vegetarian capsules.Methods: There were 100 capsule dosage forms were examined for the gelatin or HPMC wall contents and nature of medicine contained in capsules, whether ayurvedic or allopathic.Results: Out of 100 capsules studied 55 had gelatin wall base while 25 had HPMC and 20 cap

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Abolin, Craig, Dar-Shong Hwang, and Frank Mazza. "Bioavailability of Temazepam: Comparison of Four 7.5-mg Capsules with a Single 30-mg Capsule." Annals of Pharmacotherapy 27, no. 6 (1993): 695–99. http://dx.doi.org/10.1177/106002809302700602.

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OBJECTIVE: To compare the bioavailability of four temazepam 7.5-mg capsules (Restoril, Sandoz Pharmaceuticals) with that of a single temazepam 30-mg capsule. DESIGN: Single-dose, open-label, two-period, crossover (replicated Latin square). SETTING: Domiciled environment for clinical testing. PARTICIPANTS: Twenty-six healthy male volunteers aged 18–40 years; 25 completed the study. INTERVENTIONS: Subjects randomly received either four temazepam 7.5-mg capsules or one temazepam 30-mg capsule. Blood samples were drawn at various time points after each period (0-48 h), and analyzed for plasma conc

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Prabahar, A. Elphine, B. Thangabalan, R. Kalaichelvi, and P. Vijayaraj Kumar. "UV Spectrophotometric Estimation of Acipimox inBulk and Capsule Dosage Form." E-Journal of Chemistry 6, no. 4 (2009): 1117–20. http://dx.doi.org/10.1155/2009/790531.

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A new simple, rapid, accurate, sensitive and precise spectrophotometric method in ultra violet region has been developed for determination of acipimox (ACX) in bulk and capsule dosage form. Acipimox exhibited maximum absorbance at 231 nm with apparent molar absorptivity of 1.5104 × 104in distilled water. Beer’s law was found to be obeyed in the concentration range 1-10 μg mL-1. Correlation coefficient was found to be 0.9998. The developed method was validated respect to linearity, precision, accuracy. The proposed method is useful for the routine estimation of ACX in bulk and capsule dosage fo

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Mahrous, Mohamed S., Magdi M. Abdel-Khalek, and Mohamed E. Abdel-Hamid. "Colorimetric determination of two fenamates in capsule dosage form." Talanta 32, no. 8 (1985): 651–53. http://dx.doi.org/10.1016/0039-9140(85)80161-2.

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Sonar, S. P., S. B. Gondkar, and R. B. Saudagar. "Formulation and Evaluation of Liquid Filled Hard Gelatin Capsule of Febuxostat." Journal of Drug Delivery and Therapeutics 9, no. 5 (2019): 105–9. http://dx.doi.org/10.22270/jddt.v9i5.3579.

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Liquid filled hard gelatin capsule are well recognized as a solid dosage form for convenient administration of drugs orally in a liquid form. This liquid composition available help the most challenging drug compounds in capsules has increased significantly in recent years. The drugs which have low solubility, poor bioavailability, low melting point, critical stability are the perfect candidate for liquid filling in capsule. The current study presents the formulation aspects, filling and sealing aspects of capsule, evaluation parameters of the liquid filled hard gelatin capsule using Febuxostat

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Rushikesh, B. Gadekar. "A Comprehensive Review On: Capsule." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 307–20. https://doi.org/10.5281/zenodo.13895858.

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Capsules are a popular dosage form due to their stability, ease of administration, attractiveness, and compounding capabilities. They can be customized to meet individual patient needs and can incorporate multiple drugs. Special capsules can be prepared outside the norm of powders. Gelatine is widely used as a capsule shell material for hard and soft gelatine capsules. However, due to its animal origin and cross-linking properties, other non-animal materials like hydroxyl propyl methyl cellulose, starch, and poly vinyl alcohol copolymer are needed to meet the dietary and cultural needs of vege

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Palwinder, Singh* and Rajeev Garg. "FAST DISSOLVING ORAL FILMS: A NOVEL TREND IN DOSAGE FORM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 4571–78. https://doi.org/10.5281/zenodo.1256824.

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Oral routes are most commonly preferred route for drug delivery. Commonly used oral dosage forms are tablet and capsules. But many patients such as geriatric, paediatric and dysphasic patients find difficulty in swallowing conventional tablet and capsule. To overcome the problems related to swallowing, Fast dissolving Tablets (FDTs) were designed in early 19th century and hence further advancement has led to development of Fast Dissolving Oral Films (FDOFs). Many pharmaceutical groups are focusing their research on rapid dissolving technology. FDOFs technology is gaining much attention. This t

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Putri, Syakirah Yasmin, Dewi Isadiartuti, M.Si., Apt., Isnaeni Isnaeni, et al. "The Effectiveness of Vitamin E Soft Capsules as an Antioxidant." Berkala Ilmiah Kimia Farmasi 11, no. 1 (2024): 5–11. http://dx.doi.org/10.20473/bikfar.v11i1.51902.

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Antioxidants inhibit the oxidation of other molecules and play an important role in maintaining a healthy body. Antioxidants are found in fruits, vegetables, all parts of plants, and are present in the body as enzymes or products of metabolism. Vitamin E refers to a large number of natural or synthetic compounds, with alpha-tocopherol being the most active and widely distributed form in nature. Alpha-tocopherol is the most active antioxidant form of vitamin E and serves as the primary lipophilic antioxidant in plasma, membranes, and tissues. The most important function of vitamin E is its anti

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Sutiswa, Shandra Isasi, and Asep Abdul Rahman. "Celery (Apium graviolens L.) Herba Extract Capsule Formulation as Anti-Ulcer." JURNAL INFO KESEHATAN 18, no. 2 (2020): 105–12. http://dx.doi.org/10.31965/infokes.vol18.iss2.314.

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The use of medicinal plants for medicine has been prevalent since ancient times and various plants are used for public health. One of the plants that is often used in herbal medicine is celery, either directly in the form of vegetables or as an extract from the Apium graveolens L plant. Celery extract has previously been given to white mice, and can significantly protect the gastric mucosa and suppress gastric acid secretion. Traditional medicine derived from plant extracts is generally more desirable in tablet or capsule dosage forms. The objective of this study is to determine the best fille

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Salve, Priyanka M., Shital V. Sonawane, Mayuri B. Patil, and Rajendra K. Surawase. "Dissolution and Dissolution Test Apparatus: A Review." Asian Journal of Research in Pharmaceutical Sciences 11, no. 3 (2021): 229–36. http://dx.doi.org/10.52711/2231-5659.2021.00037.

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Dissolution is an official test. These used by pharmacopeias for evaluating drug release of solid and semisolid dosages forms. The application of the dissolution testing ensures consistent product quality and to predict in vivo drug bioavailability. The dissolution test, in its simplest form, placing the formulation in a dissolution apparatus containing suitable dissolution medium, allowing it to dissolved specified period of time and then using appropriate rational method to determine the amount of drug. Dissolution test are probative and analysis like drug degradation profile, shelf-life stu

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Chaganti, Soujanya, Sree Vibha Vangala, Swathi Naraparaju, Pani Kumar Durga Anumolu, and Karuna Devi Barla. "Spectrophotometric Method for Determination of Oseltamivir in Capsule Dosage Form." Scholars Academic Journal of Pharmacy 12, no. 07 (2023): 172–78. http://dx.doi.org/10.36347/sajp.2023.v12i07.002.

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Objectives: Study was aimed to establish and vindicate a simple, accurate and precise spectrophotometric method for the quantification of oseltamivir in API and capsule dosage form. Materials and Methods: The green coloured chromogen complex absorbance which was formed by the oxidative coupling with loss of two electrons and a proton of oseltamivir with MBTH in presence of FeCl3 was measured at 640nm. The amount of oseltamivir labelled in the marketed formulation (Fluvir) was determined without any interference owed with excipients. Results: A correlation coefficient of 0.999 was observed with

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Bhilegaonkar, Shilpa P., Siya Kunde, and Mrunmayee V. Naik. "CAPSULE IN CAPSULE DOSAGE FORM WITH MINI TABLETS FOR THE TREATMENT OF HELICOBACTER PYLORI." International Research Journal Of Pharmacy 9, no. 4 (2018): 29–34. http://dx.doi.org/10.7897/2230-8407.09456.

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Benke, Edit, Patrícia Varga, Piroska Szabó-Révész, and Rita Ambrus. "Stability and In Vitro Aerodynamic Studies of Inhalation Powders Containing Ciprofloxacin Hydrochloride Applying Different DPI Capsule Types." Pharmaceutics 13, no. 5 (2021): 689. http://dx.doi.org/10.3390/pharmaceutics13050689.

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In the case of capsule-based dry powder inhalation systems (DPIs), the selection of the appropriate capsule is important. The use of gelatin, gelatin-PEG, and HPMC capsules has become widespread in marketed capsule-based DPIs. We aimed to perform a stability test according to the ICH guideline in the above-mentioned three capsule types. The results of the novel combined formulated microcomposite were more favorable than those of the carrier-free formulation for all capsule types. The use of HPMC capsules results in the greatest stability and thus the best in vitro aerodynamic results for both

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Majeed, Saad M., Mohammed K. Al-Shaheen, Radhwan Nidal Al-Zidan, and Sameer M. Mahmood. "Multiple Unite Pellet Systems (MUPS) as Drug Delivery model." Journal of Drug Delivery and Therapeutics 10, no. 6 (2020): 231–35. http://dx.doi.org/10.22270/jddt.v10i6.4389.

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Multiparticulate drug delivery systems are mainly oral dosage form, consist of small discrete units that exhibit different characteristics especially in release pattern and drug bioavailability. These systems are represented by granules, pellets, microspheres, microcapsules, and minitablets. Pellets offer high flexibility in the design, formulation, and development of oral dosage forms such as sachet, suspension, capsule, and tablet. Multiparticulate tablets manufactured by compaction of multiple unite pellets is one of the latest and, yet, challenging technologies. Multiparticulate tablets co

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Shchukin, V. M., N. E. Kuz’mina, O. A. Matveeva, Yu N. Shvetsova, and E. S. Zhigilei. "Determination of Elemental Impurities in Gelatine Capsules by Inductively Coupled Plasma Mass Spectrometry." Safety and Risk of Pharmacotherapy 12, no. 2 (2024): 230–40. http://dx.doi.org/10.30895/2312-7821-2024-12-2-230-240.

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INTRODUCTION. Gelatine capsules are an essential dosage form used for many medicinal products. Gelatine capsules are subject to quality control in accordance with the requirements of the general monograph on capsules of the State Pharmacopoeia of the Russian Federation. This monograph does not standardise the content of elemental impurities, as these impurities are controlled at the raw material level. However, the equipment and excipients used in the production of gelatine capsule shells may be additional sources of impurities. Preliminary screening for chemical elements will help to assess t

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Fathi, Mona, Sohrab Kazemi, Farbod Zahedi, Mohamad Reza Shiran, and Ali Akbar Moghadamnia. "Comparison of oral bioavailability of acetaminophen tablets, capsules and effervescent dosage forms in healthy volunteers." Current Issues in Pharmacy and Medical Sciences 31, no. 1 (2018): 5–9. http://dx.doi.org/10.1515/cipms-2018-0001.

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AbstractA wide variety of acetaminophen dosage forms have been administered to relieve mild to moderate pain and fever, so far. The purpose of this study was to compare the oral bioavailability in healthy volunteers, of three of these dosage forms. We included healthy volunteers in our study and divided replace with placed them into three groups: tablet, capsule and effervescent. Each dosage form contained 500 mg of acetaminophen as active material. Blood samples were taken at 0.5, 1, 2, 4 and 8-hour intervals after receiving the dose. Acetaminophen blood levels were measured using HPLC method

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Srinivasu, K., J. Venkateswara Rao, N. Appala Raju, and K. Mukkanti. "A Validated RP-HPLC Method for the Determination of Atazanavir in Pharmaceutical Dosage Form." E-Journal of Chemistry 8, no. 1 (2011): 453–56. http://dx.doi.org/10.1155/2011/812879.

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A validated RP HPLC method for the estimation of atazanavir in capsule dosage form on YMC ODS 150 × 4.6 mm, 5 μ column using mobile phase composition of ammonium dihydrogen phosphate buffer (pH 2.5) with acetonitrile (55:45 v/v). Flow rate was maintained at 1.5 mL/min with 288 nm UV detection. The retention time obtained for atazanavir was at 4.7 min. The detector response was linear in the concentration range of 30 - 600 μg/mL. This method has been validated and shown to be specific, sensitive, precise, linear, accurate, rugged, robust and fast. Hence, this method can be applied for routine q

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Kute, Vaibhav Ghansham, Rajeshwari Satish Patil, Vaishnavi Ghansham Kute, and Priti Dilip Kaluse. "Immediate-release dosage form; focus on disintegrants use as a promising excipient." Journal of Drug Delivery and Therapeutics 13, no. 9 (2023): 170–80. http://dx.doi.org/10.22270/jddt.v13i9.6217.

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Disintegrants are materials or mixtures of substances added in the drug formulations, which make easier dispersion or breakup of tablets and ingredients of capsules in small-scale particles for fast dissolution then it comes in contact with water in the GI tract. Immediate drug release dosage forms disintegrate rapidly after administration with an enhanced rate of dissolution. The superdisintegrants provide instantaneous disintegration of tablets after administration in the stomach. In this field, immediate-release liquid dosage forms and parenteral dosage forms have also been introduced for t

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Liu, Xing, Jun-Li Huo, Ting-Ting Li, Hao-Kai Peng, Jia-Horng Lin, and Ching-Wen Lou. "Investigation of the Shear Thickening Fluid Encapsulation in an Orifice Coagulation Bath." Polymers 11, no. 3 (2019): 519. http://dx.doi.org/10.3390/polym11030519.

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The orifice coagulation bath method is proposed to encapsulate shear thickening fluid (STF) to form STF capsules, in an attempt to improve the combination of STF and the matrix as well as strengthen the flexibility and stability of the STF composites. By varying the calcium chloride concentration (10, 20 mg/ml), sodium alginate concentration (5, 7, 10 mg/ml) and the surfactant dosage (10%, 20%, 30%), optimal preparation conditions were studied, considering the capsule strength and encapsulation rate. The capsules were also characterized using a scanning electron microscope (SEM), Fourier trans

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Joshi, Sameer, Rajnish Sahu, Vida A. Dennis, and Shree R. Singh. "Nanofiller-Enhanced Soft Non-Gelatin Alginate Capsules for Modified Drug Delivery." Pharmaceuticals 14, no. 4 (2021): 355. http://dx.doi.org/10.3390/ph14040355.

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Capsules are one of the major solid dosage forms available in a variety of compositions and shapes. Developments in this dosage form are not new, but the production of non-gelatin capsules is a recent trend. In pharmaceutical as well as other biomedical research, alginate has great versatility. On the other hand, the use of inorganic material to enhance material strength is a common research topic in tissue engineering. The research presented here is a combination of qualities of alginate and montmorillonite (MMT). These two materials were used in this research to produce a soft non-gelatin mo

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Sadraei, Hassan, Amir Hossein Rasouli-Amirabadi, Afsaneh Yekdaneh, and Naser Tavakoli. "Bioassay standardization of drug dosage form prepared from hydroalcoholic extract of Dracocephalum kotschyi ." Journal of Herbmed Pharmacology 11, no. 3 (2022): 435–43. http://dx.doi.org/10.34172/jhp.2022.50.

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Introduction: Zaringiah (Dracocephalum kotschyi) is a famous Iranian herbal plant with anti-inflammatory and spasmolytic activities. There is no standard drug dosage form for the D. kotschyi extract on the market. The objective of this project was to design a suitable oral dosage form for the hydroalcoholic extract of D. kotschyi. Methods: Standard granules were prepared using the moist granulation technique. Physical properties of the granules were determined before filling the capsule with fixed doses of the drug (25 mg and 50 mg). Syrup was prepared in sucrose solution at 5 mg/mL concentrat

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Sherje, AP, AV Kasture, KN Gujar, and PG Yeole. "Simultaneous spectrophotometric determination of lansoprazole and domperidone in capsule dosage form." Indian Journal of Pharmaceutical Sciences 70, no. 1 (2008): 102. http://dx.doi.org/10.4103/0250-474x.40343.

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Lin, Jian, Chunchan Zhang, Yaoxiang Gao, Xiaojun Zhao, and Xican Li. "A Validated HPLC Method for Determining Melatonin in Capsule Dosage Form." Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery 2, no. 3 (2012): 147. http://dx.doi.org/10.5455/spatula.20120906112559.

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Behera, Anindita, Swapan Kumar Moitra, Sudam Chandra Si, and Dannana Gowri Sankar. "Spectrophotometric method for determination of atazanavir sulfate in capsule dosage form." Química Nova 34, no. 8 (2011): 1349–53. http://dx.doi.org/10.1590/s0100-40422011000800010.

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Rump, Adrian, Marie-Luise Kromrey, Eberhard Scheuch, et al. "In Vivo Evaluation of a Gastro-Resistant HPMC-Based “Next Generation Enteric” Capsule." Pharmaceutics 14, no. 10 (2022): 1999. http://dx.doi.org/10.3390/pharmaceutics14101999.

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Many orally dosed APIs are bioavailable only when formulated as an enteric dosage form to protect them from the harsh environment of the stomach. However, an enteric formulation is often accompanied with a higher development effort in the first place and the potential degradation of fragile APIs during the coating process. Ready-to-use enteric hard capsules would be an easily available alternative to test and develop APIs in enteric formulations, while decreasing the time and cost of process development. In this regard, Lonza Capsugel® Next Generation Enteric capsules offer a promising approac

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Behera, A., D. G. Sankar, S. K. Moitra, and S. C. Si. "Development, Validation and Statistical Correlation of RP–LC Methods for Determination of Atazanavir Sulfate in Capsule Dosage Form." E-Journal of Chemistry 9, no. 4 (2012): 1778–87. http://dx.doi.org/10.1155/2012/402970.

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To study the effective therapeutic bioavailability of Atazanavir Sulfate (ATV), administered singly or in combination with Ritonavir, a cost effective and rapid method is required. In order to assess an in-depth study, it is primarily thought prudent to develop an effective analytical method for estimation of ATV in marketed dosage forms. The present work is to develop a simple and precise analytical method for in depth evaluation of therapeutic efficacy of ATV. The novelty of the method shows linearity in the concentration range of 10-100 µg/mL at two wavelengths, i.e. 254 nm and 284 nm respe

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Dhaval, Mori, Jalpa Makwana, Ekta Sakariya, and Kiran Dudhat. "Drug Nanocrystals: A Comprehensive Review with Current Regulatory Guidelines." Current Drug Delivery 17, no. 6 (2020): 470–82. http://dx.doi.org/10.2174/1567201817666200512104833.

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Drug nanocrystals offer an attractive approach for improving the solubility and dissolution rate of poorly soluble drugs which accounts for nearly 40 % newly discovered drug molecules. Both methods for manufacturing drug nanocrystals have high industrial acceptability for being simple and easy to scale which is evident from the number of approved products available in the market. Ability to modify multiple aspects of dosage form like bioavailability, release pattern and dosage form requirement along with flexibility in choosing final dosage form starting from the tablet, capsule, suspension to

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Raihan, Roshaan, Azimullah Wafa, Aqa Mohammad Zhakfar, and Sudhakar CK. "Oral Disintegrating Films: A Review." Journal of Natural Science Review 2, no. 2 (2024): 60–74. http://dx.doi.org/10.62810/jnsr.v2i2.42.

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The oral route stands out as a preferred method for drug administration due to its cost-effectiveness and ease, contributing to enhanced patient compliance. Some individuals, particularly the geriatric and pediatric populations, encounter difficulties swallowing conventional tablets and hard gelatin capsules. To address this, oral disintegrating drug delivery systems are established as substitutes for tablets, capsules, and syrups. Notably, fast-dissolving oral thin films offer a practical solution for patients such as those in pediatric, bedridden, or developmentally disabled categories, as w

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Onokala, Lillian, Garrard Baker, and Bisrat Hailemeskel. "Price Comparison of Moringa in the Greater District of Columbia Area, United States of America." Advances in Food Technology and Nutrition Sciences – Open Journal 8, no. 1 (2022): 14–19. http://dx.doi.org/10.17140/aftnsoj-8-175.

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Introduction Moringa oleifera (MO) is a nutritional herbal supplement that grows in many subtropical and tropical regions of the world including India, Africa, North and South America, and Asia. The purpose of this study is to review recent clinical studies regarding the health benefits of MO as well as investigate the availability and relative pricing of MO among retail local and online stores for the various Moringa dosage forms. Method In this study, price variations and availability of MO in 18 retail companies that serve the District of Columbia, Maryland, and Virginia region were investi

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Huynh, Thi My Duyen, Thanh Sil Nguyen, Kien Tuong Ta, and Thi Minh Ngoc Le. "RESEARCH ON FORMULATION OF HARD CAPSULES CONTAINING EXTRACTS OF HOUTTUYNIA CORDATA THUMB (SAURURACEAE), MORUS ALBA L. (MORACEAE), AND CARICA PAPAYA L. (CARICACEAE)." Tạp chí Y Dược học Cần Thơ, no. 6 (October 20, 2023): 150–58. http://dx.doi.org/10.58490/ctump.2023i6.1227.

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Background: previous studies have demonstrated that Houttuynia cordata Thumb (Saururaceae), Morus alba L. (Moraceae), and Carica papaya L. (Caricaceae) are effective against various viruses, especially the SARS-CoV-2 virus. In Vietnam, even though the three of these plant species are grown quite popularly and are pretty commonly consumed by residents regularly, there have not been any applications to the dosage forms to promote their full potential effects and make these dosage forms easy to use and preserve. Furthermore, no research has been conducted on a capsule form that combines all three

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Singh, Rajnish Kumar, Naveen Kumar Choudhary, and Ankit Anand Kharia. "Formulation Development and Release Profile of Levomilnacipran Extended Release Capsules using Principles of Quality by Design." Asian Pacific Journal of Health Sciences 9, no. 4 (2022): 214–16. http://dx.doi.org/10.21276/apjhs.2022.9.4s1.39.

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The study’s goal was to use Quality By Design (QbD) principles to design an Extended Release dosage form of levomilnacipran and evaluate its in vitro release profile. Doses of levomilnacipran extended release capsules (LERC) ranging from 20 mg to 120 mg. QbD was employed in this work to design LERC capsule formulation and production, which ensures LERC safety and efficacy. To create the LERC, wurster coating was applied to non-pariel seeds, which were then filled with capsules. To provide prolonged absorption, a polymer derived from ethylcellulose was chosen. Extensive release capsules are mad

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Tzakri, Theodora, Lara Rehenbrock, Stefan Senekowitsch, et al. "Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a Compression-Coated Tablet and Salivary Caffeine Kinetics." Pharmaceutics 15, no. 11 (2023): 2584. http://dx.doi.org/10.3390/pharmaceutics15112584.

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Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine as a salivary tracer. Despite the ice capsule’s advantage in labeling ingested fluids with caffeine for subsequent salivary detection, its risk of premature melting before swallowing, and its complicated storage and preparation, limit its application, particularly in special populations (e.g., older people). For this reason, here, a compression-coated tablet was deve

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Robson, J., G. Snow, J. Y. Park, R. C. Moretz, H. O. Krenkel, and A. Angel. "Microscopic evaluation of structural changes in brittle, hydrated, gelatin capsules." Proceedings, annual meeting, Electron Microscopy Society of America 50, no. 1 (1992): 780–81. http://dx.doi.org/10.1017/s0424820100124306.

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Gelatin capsules are a commonly used dosage form for prescription medications. Storage conditions as well as drug formulation can directly affect capsule integrity over time. Often, capsule brittleness following storage can be related to water loss. In this report an encapsulated drug formulation containing 77% anhydrous citric acid became brittle following two years of storage at 25° C/60% RH. However, Thermogravimetric data showed that capsule brittleness did not result from changes in water content. Both normal(without drug formulation) and brittle capsules contained 12% water. Microscopy w

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Shaikh, Siddiqua, and Prerana Jadhav. "RP-HPLC Method Development and Validation for the Simultaneous Estimation of Amitriptyline Hydrochloride and Pantoprazole Sodium in Bulk and Capsule Dosage Form." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 37–42. http://dx.doi.org/10.22270/jddt.v9i4.2978.

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A simple, rapid, accurate and precise isocratic reversed phase high performance liquid chromatographic method has been developed and validated for Simultaneous Estimation of Pantoprazole Sodium (PNT) and Amitriptyline Hydrochloride in Bulk and Capsule Dosage Form. In RP-HPLC method, the analyte were resolved by using isocratic program, methanol and phosphate buffer (80:20v/v) was used as mobile phase, at a flow rate of 0.8 ml/min. on HPLC system containing UV-visible detector with Workstation software and cosmosil 18 (250 mm × 4.6 mm,5 μm) column. The detection was carried out at 244nm. The re

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Klinger, Janosch, and Rolf Daniels. "Assessing a Mass-Based Method for the Preparation of Low-Dosed Paediatric Capsules with Baclofen and Spironolactone." Pharmacy 9, no. 1 (2021): 56. http://dx.doi.org/10.3390/pharmacy9010056.

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Despite the steadily improving medical care situation in pediatrics, some drugs are still not available in a suitable dose or dosage form and thus need to be prepared extemporaneously. Capsules can be easily compounded at the hospital and public pharmacies, offering an alternative to liquid formulations. This study aims at testing a mass-based approach for the extemporaneous preparation of low-dose pediatric capsules and investigating systematically the API loss during this procedure. A total of 54 capsule batches were prepared with baclofen and spironolactone as pediatric-relevant drugs. The

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NK, Shinde, and Mane DV. "Development and Evaluation of Antifungal Drug Product by Solid Dispersion Technique using Drug Coating and Seal Coating Approach (Itraconazole Capsules 100 mg)." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1116–23. https://doi.org/10.25258/ijddt.14.4.28.

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A very important stage in developing and preserving the quality of any pharmaceutical drug product is validation. Drug product validation creates the written proof that offers a high level of certainty that a manufacturing process will reliably provide a product with predefined standards and quality features. Studying the process performance certification of the drug product Itraconazole Capsules 100 mg Immediate Release Capsule dosage form was the primary goal of my research. The research conducted here guarantees that the production process is appropriate for the intended use and that the fi

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Jha, Preeta, Rabea Parveen, Suroor A. Khan, Ozair Alam, and Sayeed Ahmad. "Stability-Indicating High-Performance Thin-Layer Chromatographic Method for Quantitative Determination of Omeprazole in Capsule Dosage Form." Journal of AOAC INTERNATIONAL 93, no. 3 (2010): 787–91. http://dx.doi.org/10.1093/jaoac/93.3.787.

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Abstract A novel HPTLC method has been developed and validated for quantitative determination of omeprazole (OPZ) in capsule dosage form. The method was validated according to the International Conference on Harmonization guidelines for accuracy, precision, linearity, specificity, and robustness. HPTLC aluminum sheets precoated with silica gel 60F254 were used as the stationary phase and chloroformmethanol (9 + 1) as the mobile phase. The mobile phase was found to give compact bands for OPZ (Rf value of 0.39 0.12) in densitometric analysis in the absorbance mode at 302 nm. The linear regressio

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Xu, Xiaohui, and J. T. Stewart. "MEKC DETERMINATION OF GUAIFENESIN, PSEUDOEPHEDRINE, AND DEXTROMETHORPHAN IN A CAPSULE DOSAGE FORM." Journal of Liquid Chromatography & Related Technologies 23, no. 1 (2000): 1–13. http://dx.doi.org/10.1081/jlc-100101431.

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Abed Al- Rahman, Issraa Rasheed, Alaa A. A.Rasool, and Fatima A. Tawfiq. "A Modified Organic Method for Preparation of Ibuprofen Microcapsules As a Sustained Release Solid Dosage Form." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 14, no. 1 (2017): 1–11. http://dx.doi.org/10.31351/vol14iss1pp1-11.

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ABSTRACT:Microencapsulation is used to modify and retard drug release as well as to overcome the unpleasant effect(gastrointestinal disturbances) which are associated with repeated and overdose of ibuprofen per day.So that, a newly developed method of microencapsulation was utilized (a modified organic method) through amodification of aqueous colloidal polymer dispersion method using ethylcellulose and sodium alginate coating materials toprepare a sustained release ibuprofen microcapsules.The effect of core : wall ratio on the percent yield and encapsulation efficiency of prepared microcapsule

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Nerdy, Nerdy, Linda Margata, Nilsya Febrika Zebua, et al. "Development and Validation of Fast and Simple Fourier Transform Infrared Spectrophotometric Method for Analysis of Thiamphenicol in Capsule Dosage Form." Science and Technology Indonesia 8, no. 3 (2023): 344–52. http://dx.doi.org/10.26554/sti.2023.8.3.344-352.

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The development of a method for identification and determination of thiamphenicol by Fourier Transform Infrared will provide convenience to developers because it is fast and easy for analysis. The research was carried out by utilizing the solubility of thiamphenicol in methanol with three stages, namely method development, sample analysis, and method validation. The method development stage showed that the specific peak of thiamphenicol was at a peak with a wavenumber of 1694.1 cm−1; this specific peak of thiamphenicol was used for qualitative analysis and quantitative analysis of thiamphenico

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Muno, Francis J. "Broadening Utility of Tablet and Capsule Imprints." Journal of Pharmacy Practice 13, no. 2 (2000): 130–40. http://dx.doi.org/10.1177/089719000001300204.

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From a strategic 1962 article cataloging the imprints on tablets, capsules and softgels, the art of identification of solid medication dosage form has proceeded to where all prescription medications, including controlled substance, over-the-counter (OTC) drugs, veterinary and homeopathic drug products must be imprinted. Imprints may be comprised of logos, numerical and/or alphabetical information. Imprints are electronically searchable by two computer programs, one of which provides graphics of logos. The public and health, law enforcement and teaching professionals have a need to know when a

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