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1

Zucker, I. H., J. S. Chen, and W. Wang. "Renal sympathetic nerve and hemodynamic responses to captopril in conscious dogs: role of prostaglandins." American Journal of Physiology-Heart and Circulatory Physiology 260, no. 1 (January 1, 1991): H260—H266. http://dx.doi.org/10.1152/ajpheart.1991.260.1.h260.

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The angiotensin converting enzyme inhibitor captopril has been shown to cause resetting of the arterial baroreflex to a lower pressure without a change in gain. The present study was conducted to determine whether captopril altered the relationship between arterial pressure, heart rate, and renal sympathetic nerve activity in conscious quietly resting dogs. Fourteen instrumented dogs were given 2 mg/kg iv of captopril; 10 min later postcaptopril measurements were made. Six of the fourteen dogs were pretreated with cyclooxygenase inhibitor (indomethacin or meclofenamate) before administration of captopril. Renal nerve activity and hemodynamics were measured in a final group of eight dogs in which arterial pressure was lowered with a graded infusion of sodium nitroprusside. Captopril caused a small but significant decrease in arterial pressure. This decrease in arterial pressure was accompanied by a significant increase in heart rate; however, renal sympathetic nerve activity was significantly reduced. In contrast, dogs receiving nitroprusside exhibited an increase in both heart rate and renal sympathetic nerve activity in response to similar decreases in arterial pressure. Dogs that received cyclooxygenase inhibitor showed reduced arterial pressure in response to captopril, increased heart rate, and increased renal sympathetic nerve activity. This study is the first to report a decrease in sympathetic nerve activity in response to captopril in an awake chronically instrumented animals. These data suggest that captopril's ability to augment prostaglandin synthesis is responsible for the observed sympathoinhibition.
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2

Sastrosubroto, Hardiman, Santosa Soeroso, and Eriyati Indrasanto. "Captopril Treatment in Rheumatic Heart Disease with Congestive Heart Failure A Preliminary Report." Paediatrica Indonesiana 29, no. 9-10 (March 20, 2018): 209–14. http://dx.doi.org/10.14238/pi29.9-10.1989.209-14.

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A small scale controlled trial of captopril (ACE inhibitor) was conducted in 8 children with congestive heart failure due to rheumatic mitral regurgitation with or without mild mitral stenosis. The age of the patient ranged from 5.5 to 13 years (mean 9,3 years). Four children, served as control group, received digitalis and diuretics as standard treatment; while the other 4 children also received 2 x 12,5 mg of captopril in addition to standard treatment. The effect of both regimens were measured by usingchanges of left ventricular function as seen on the echocardiogram performed before treatment, and then 3, 7 and 14 days thereafter. Definite conclusion cannot be made because of the small number of patients; but it is apparent that some improvements of left ventricular functions in the captopril group were more evident when compared with that of the control group of standard treatment.Side effects of captopri/ were not found.
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3

&NA;. "Captopril." Reactions Weekly &NA;, no. 1393 (March 2012): 12. http://dx.doi.org/10.2165/00128415-201213930-00035.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 722 (October 1998): 7–8. http://dx.doi.org/10.2165/00128415-199807220-00012.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 727 (November 1998): 7. http://dx.doi.org/10.2165/00128415-199807270-00017.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 733 (January 1999): 7. http://dx.doi.org/10.2165/00128415-199907330-00010.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 1152 (May 2007): 8. http://dx.doi.org/10.2165/00128415-200711520-00024.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 1364 (August 2011): 12. http://dx.doi.org/10.2165/00128415-201113640-00044.

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9

&NA;. "Captopril." Reactions Weekly &NA;, no. 535 (January 1995): 5. http://dx.doi.org/10.2165/00128415-199505350-00016.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 539 (February 1995): 5. http://dx.doi.org/10.2165/00128415-199505390-00007.

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11

&NA;. "Captopril." Reactions Weekly &NA;, no. 546 (April 1995): 5. http://dx.doi.org/10.2165/00128415-199505460-00015.

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12

&NA;. "Captopril." Reactions Weekly &NA;, no. 574 (October 1995): 5. http://dx.doi.org/10.2165/00128415-199505740-00012.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 583 (January 1996): 7. http://dx.doi.org/10.2165/00128415-199605830-00015.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 429 (November 1992): 6. http://dx.doi.org/10.2165/00128415-199204290-00023.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 433 (January 1993): 7. http://dx.doi.org/10.2165/00128415-199304330-00025.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 440 (February 1993): 7. http://dx.doi.org/10.2165/00128415-199304400-00024.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 443 (March 1993): 7. http://dx.doi.org/10.2165/00128415-199304430-00026.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 446 (April 1993): 7. http://dx.doi.org/10.2165/00128415-199304460-00025.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 451 (May 1993): 6. http://dx.doi.org/10.2165/00128415-199304510-00020.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 452 (May 1993): 6. http://dx.doi.org/10.2165/00128415-199304520-00024.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 457 (June 1993): 6. http://dx.doi.org/10.2165/00128415-199304570-00024.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 465 (August 1993): 6. http://dx.doi.org/10.2165/00128415-199304650-00022.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 471 (October 1993): 6. http://dx.doi.org/10.2165/00128415-199304710-00024.

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24

Brogden, Rex N., Peter A. Todd, and Eugene M. Sorkin. "Captopril." Drugs 36, no. 5 (November 1988): 540–600. http://dx.doi.org/10.2165/00003495-198836050-00003.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 610 (July 1996): 7. http://dx.doi.org/10.2165/00128415-199606100-00021.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 615 (August 1996): 7. http://dx.doi.org/10.2165/00128415-199606150-00015.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 682 (December 1997): 6–7. http://dx.doi.org/10.2165/00128415-199706820-00020.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 777 (November 1999): 7. http://dx.doi.org/10.2165/00128415-199907770-00011.

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29

&NA;. "Captopril." Reactions Weekly &NA;, no. 373 (October 1991): 4. http://dx.doi.org/10.2165/00128415-199103730-00015.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 377 (November 1991): 5. http://dx.doi.org/10.2165/00128415-199103770-00016.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 387 (February 1992): 4. http://dx.doi.org/10.2165/00128415-199203870-00009.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 389 (February 1992): 6. http://dx.doi.org/10.2165/00128415-199203890-00019.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 392 (March 1992): 5. http://dx.doi.org/10.2165/00128415-199203920-00015.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 398 (April 1992): 5. http://dx.doi.org/10.2165/00128415-199203980-00009.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 399 (May 1992): 5. http://dx.doi.org/10.2165/00128415-199203990-00009.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 401 (May 1992): 5. http://dx.doi.org/10.2165/00128415-199204010-00010.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 405 (June 1992): 6. http://dx.doi.org/10.2165/00128415-199204050-00018.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 407 (June 1992): 4. http://dx.doi.org/10.2165/00128415-199204070-00005.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 410 (July 1992): 5. http://dx.doi.org/10.2165/00128415-199204100-00015.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 418 (September 1992): 6. http://dx.doi.org/10.2165/00128415-199204180-00016.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 421 (October 1992): 7. http://dx.doi.org/10.2165/00128415-199204210-00024.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 422 (October 1992): 7. http://dx.doi.org/10.2165/00128415-199204220-00022.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 1203 (May 2008): 14. http://dx.doi.org/10.2165/00128415-200812030-00042.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 1212 (July 2008): 11. http://dx.doi.org/10.2165/00128415-200812120-00034.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 1089 (February 2006): 8. http://dx.doi.org/10.2165/00128415-200610890-00021.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 1089 (February 2006): 8–9. http://dx.doi.org/10.2165/00128415-200610890-00022.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 1112 (July 2006): 9. http://dx.doi.org/10.2165/00128415-200611120-00024.

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48

Plosker, Greg L., and Donna McTavish. "Captopril." Drugs & Aging 7, no. 3 (1995): 226–53. http://dx.doi.org/10.2165/00002512-199507030-00007.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 884 (January 2002): 7. http://dx.doi.org/10.2165/00128415-200208840-00019.

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&NA;. "Captopril." Reactions Weekly &NA;, no. 886 (January 2002): 6. http://dx.doi.org/10.2165/00128415-200208860-00015.

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