Journal articles: 'CAR SALON'

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Давыдов, V. Davydov, Ворожнин, Vladimir Vorozhnin, Трофименко, Yuri Trofimenko, Зубова, and S. Zubova. "Air Purification Efficiency Assessment on Large City’s Street Road Network by Green Plantings and Photocatalytic Cleaners." Safety in Technosphere 3, no. 6 (December 23, 2014): 53–60. http://dx.doi.org/10.12737/6639.

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Methods for organization of air purification on Yekaterinburg city’s street road network are considered.Air pollution by motor transport and a polluting substances stream to the car salon are estimated with a use of the received consistent patterns, dispersive models, transport streams’ characteristics, and data on current weather conditions. On a streams’ balance basis a permissible density of cars (on the non-exceedance of CO maximum permissible threshold) on the city’s territory (no more than 12-12.5 cars/sq. km) taking into account their emissions and work of photocatalytic cleaners in vehicles’ salons and photocatalytic coverings on the street road network surfaces (acoustic screens, sidewalks, buildings), and also due to processing of the polluting substances by different types of wood vegetation (protective forest strips, parks and forest parks) has been established. It has been defined that the removal of CO by means of available city vegetation is equivalent to additional presence on the city’s streets of 0.2-0.4 % of cars of the operated transport’s total number without air deterioration. A necessary area of an active surface for photocatalytic cleaners in the car salon (0.1 sq. m), bus salon (0.5 sq. m), and also a width of protecting surfaces with the deposited photocatalytic coverings near the pedestrian zone (5m) are estimated in this work. It has been established that sharing of the considered cleaning methods is capable to lead to annual decrease of carbon oxide from 0.14 to 6 %, and nitrogen oxides from 0.15 to 5.78 % in average concentration around the city.

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Pangestu, Valentina, Gervasius Herry Purwoko, and Stephanus Evert Indrawan. "PERANCANGAN KAFE BAPAK DI SIDOARJO." AKSEN 4, no. 1 (December 5, 2019): 89–111. http://dx.doi.org/10.37715/aksen.v4i1.1035.

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Proyek akhir perancangan Kafe Bapak merupakan proyek desain interior dan eksterior pada bangunan yang terletak di Jalan Letjen sutoyo no. 3, Waru, Sidoarjo. Perancangan ini dilatar belakangi oleh keinginan klien untuk membuat sebuah bangunan multibisnis yang unik, cozy, dan artful. Adapun tujuan dibangunnya Kafe Bapak yaitu sebagai sarana penyedia layanan yang masih sulit ditemui pada daerah tersebut, diantaranya kafe, car wash, salon & reflexology, dan multi function hall. Perancangan ini bertujuan menjawab keinginan klien serta memberi solusi atas permasalahan yang terdapat pada bangunan eksisting proyek. Konsep yang digunakan untuk menyelesaikan problem terinspirasi dari bentuk kurva melengkung yang terdapat pada bagian tengah biji kopi. Kurva ini kemudian diaplikasikan pada penataan layout dan pelingkup secara tiga dimensi. Ruang-ruang dalam Kafe Bapak diorganisasi sesuai kedekatan fungsi, sehingga membuat pola sirkulasi yang efisien bagi penggunanya. Dalam perancangan ini material - finishing pelingkup dan isi ruang yang dipilih merupakan bahan-bahan yang ramah lingkungan dan pengguna.

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Zaritskyi, H. "CHALLENGING ISSUES RELATING TO COMPREHENSIVE EXAMINATION IN MOTOR VEHICLE INJURIES: FORENSIC MEDICAL ASPECTS." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 20, no. 3 (November 12, 2020): 192–96. http://dx.doi.org/10.31718/2077-1096.20.3.192.

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Motor vehicle traumas are among the most common causes of injury both in Ukraine and around the world. Comprehensive examinations enable investigating and judicial authorities to investigate and detect crimes in cases of motor accident. The purpose of the study was to identify the most common challenging issues arising during the complex expert examinations traumas caused by motor vehicle accidents (MVA) and the ways to solve them by analyzing data obtained from forensic examinations of non-survivors in motor vehicle accidents in Ukraine. Results and discussion. According to 45 complex examination reports from the State Institution «Main Bureau of Forensic Medical Examination of the Ministry of Health of Ukraine» it was impossible to identify the position of the victims at the moment of trauma (and to identify the places the victims set in the car salon) due to the lack of primary data in 20% of the cases studied; and in only 5 cases it was possibility to establish the position of the victims at the moment of injury. Determining the location of the victim in the car, pedestrian, etc. can be only identified by characteristic and specific injuries, which are not always paid attention during the initial examination of cadavers. A lot of medical records can omit the description of some injuries (size, localization, shape, morphological features, etc.) or do not provide complete information that impedes the investigative of motor vehicle accidents. Another cause to identify the position of MVA non-survivor is inability to indicate the mechanism and sequence of damage to the car during the auto-technical expert examination. Conclusion. The study has shown that the main factors impeding the MVA investigation and clarifying the picture of event are: violation of the «Rules for conducting forensic expert examination of corpses in the forensic examination bureau» during the initial examination; the absence or poor quality description in the protocols and guidelines for the inspection of the accident scene, including physical evidence and the condition of the vehicle; the inability to establish the nature of injuries on the body of victims or non-survivors and damage to vehicles due to delays in the investigation of crimes; drawbacks in filling in and keeping medical documentation: absence or incomplete description of damage (size, shape, location, morphological features, etc.).

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Nur, Edwar M., and Chairul Ichsan. "Kualitas Jasa, Harga dan Pengaruhnya Terhadap Kepuasan Pelanggan." Jurnal Humaniora : Jurnal Ilmu Sosial, Ekonomi dan Hukum 2, no. 1 (March 9, 2019): 10–18. http://dx.doi.org/10.30601/humaniora.v2i1.49.

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This business emerged in response to the demands of people who wanted an efficient form of time-care business. The need for auto repair shops and car salon in one roof has increased. Therefore the market potential of this field of business is very large. The purpose of this study is to determine the effect of service quality and price simultaneously on customer satisfaction of Sehat Workshop in Banda Aceh, to know the effect of service quality partially on customer satisfaction of Sehat Workshop in Banda Aceh and to know the effect of price partially on customer satisfaction Sehat Workshop in Banda Aceh . This research was conducted at Sehat workshop branch of Banda Aceh which is located at P.Nyak Makam Street. No.167. Lambhuk Kota Banda Aceh, while the object of this study is about the quality of service and customer satisfaction using the service of Sehat Workshop Banda Aceh, with the number of respondents as many as 150 people. The results showed that the quality of services and prices together significantly affect the satisfaction of consumers Sehat Workshop in Banda Aceh, then the quality of service products from the Sehat Workshop individually significantly affect the satisfaction of consumers of service users Sehat Workshop Banda Aceh and individually prices given by Sehat Workshop individually have an effect on significantly to customer satisfaction of service user of Sehat Workshop of Banda Aceh.

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Rakib Uddin, Mohammad, and Muhammad Faiz Haji Ya’akub. "Parked Car Interior Temperature Investigation in Brunei Darussalam." International Journal of Engineering Materials and Manufacture 5, no. 1 (March 26, 2020): 12–18. http://dx.doi.org/10.26776/ijemm.05.01.2020.03.

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When a car is parked under the sunlight for a long period of time, solar radiation enters the vehicle through the car glass and becomes trapped inside the car. This causes the cabin interior air temperature to increase and this is especially noticeable in tropical countries with hot and humid climates that are situated near the equator like Brunei Darussalam. Aside from causing thermal discomfort to the passengers inside the car, degradation of the surfaces of the car interior may also be accelerated. This paper aims to demonstrate the severity of the heat by recording a number of temperature measurements in a certain period of time for two different types of cars, under three different conditions for each car and comparing them to the ambient temperature. It is observed that the interior temperature depends on the design of the car. We experimented temperature measurements for two types of car models, i.e., saloon and SUV models. Saloon car is design such as way that its interior volumes space is smaller than the SUV designed car. The smaller interior volume spaced Saloon car exhibits higher maximum temperature of 68.7°C whereas the larger interior volume spaced SUV car exhibits maximum temperature of 59.4°C under fully exposed to sun with same environmental conditions.

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Pinault, Steven C. "Safe Car Following (Vincent Salmon)." SIAM Review 30, no. 3 (September 1988): 507–8. http://dx.doi.org/10.1137/1030106.

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Sook-Fern Yeo, Cheng-Ling Tan, Kah-Boon Lim, and Elaine Lam. "Influencing Factors of Facial Spa Treatment on Visit Intention: An Importance-Performance Matrix Analysis (IPMA) Approach." International Journal of Business and Society 21, no. 3 (April 23, 2021): 1087–100. http://dx.doi.org/10.33736/ijbs.3313.2020.

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Nowadays, grooming is considered an essential part of life to maintaining and up keeping a healthy and hygienic outlook which plays a key role in social bonding. As it turns out, the desire to looking good has spawned a wide range of beauty products causing the beauty industry to thrive and grow at a rapid rate. In other words the Malaysian Beauty Salon Markets have become big business today, driven by a rising population, disposable incomes, urbanisation and increasing influence of western culture to look good and to feel good. The beauty market is valued at USD 119.24 million and is expected to grow at a CAGR of 5.23% in the next five years, to USD 153.86 million in 2015. As a result of a highly fragmented in this market, the need for differentiation from other salons is impendency for this industry. This research aims to study the different attributes of customer's concerns and reveals the final factors that generate customer intention to visit facial spa treatment centres in Malaysia. The effort is devoted to identifying those dimensions of services provided in facial spa treatment centres for instance, atmospheric, service quality, price, brand image and location which aid to build up a greater relationship with their patrons. Data is collected via questionnaires distribution from the target population of the female with the age range from 16-63 years old. A sample size of 308 was studied and data analysis involving Structural Equation Modeling SmartPLS version 3.0 software were used. Service quality reached the conclusion as the strongest predictor in influencing customer intention to visit facial spa treatment centres, followed by the factors of price and brand image. Further to that, an Importance-Performance matrix analysis was conducted in order to identify factors that need to be given priority for spa owners in Malaysia. These findings made contributions beyond the high context services for instance beauty salons, massage salons, hair salons, nail salons, financial consulting and medical care with the matching services characteristics.

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Wagner, Graham F., Ewa M. Jaworski, and Michel Haddad. "Stanniocalcin in the seawater salmon: structure, function, and regulation." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 274, no. 4 (April 1, 1998): R1177—R1185. http://dx.doi.org/10.1152/ajpregu.1998.274.4.r1177.

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Stanniocalcin (STC) is a homodimeric glycoprotein hormone that was first discovered in fish, where it is produced by unique endocrine glands known as the corpuscles of Stannius (CS). In freshwater salmon, STC plays an integral role in Ca2+ and phosphate homeostasis. High levels of extracellular Ca2+promote the synthesis and release of STC, which on entering the bloodstream reduces the levels of gill and gut Ca2+ transport and renal phosphate excretion to restore normocalcemia. In this report, we have examined STC in seawater salmon. We have studied the distribution of STC protein and mRNA in marine Atlantic salmon CS cells, the responsiveness of these cells to Ca2+, and some physical properties of the hormone. Our results demonstrated that all Atlantic salmon CS cells expressed the STC gene. Furthermore, these cells exhibited a Ca2+ sensitivity that was remarkably similar to those in freshwater salmon in terms of its ability to stimulate STC secretion and gene expression. When Atlantic salmon glands were fractionated by concanavalin A (ConA)-Sepharose chromatography, two distinct forms of the hormone were identified, both of which were recognized by sockeye salmon STC antiserum, and designated as STC1 and STC2. STC1 was a glycosylated, 42-kDa disulfide-linked dimer, with a high affinity for ConA. STC2 did not bind to ConA, was 44 kDa in size, and had a different subunit structure. STC2 was also a less effective inhibitor of gill Ca2+ transport in fish. Collectively, the results suggest that there is a second form of STC in salmon.

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Dove, Rita. "First Contact: (Ignaz Schuppanzigh’s apartments. A musical salon.)." Callaloo 31, no. 3 (2008): 688–89. http://dx.doi.org/10.1353/cal.0.0211.

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Rita Dove. "First Contact: (Ignaz Schuppanzigh’s apartments. A musical salon.)." Callaloo 31, no. 3 (2008): 688–89. http://dx.doi.org/10.1353/cal.0.0231.

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Ródenas García, Juan Fernando. "Antonio Bonet and Josep Puig Torné. Triangular Patterns in Cap de Salou." Ra. Revista de Arquitectura 17 (December 22, 2015): 57–64. http://dx.doi.org/10.15581/014.17.57-64.

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Koitrand, Sofie, Lennart Lofdahl, Sven Rehnberg, and Adrian Gaylard. "A Computational Investigation of Ground Simulation for a Saloon Car." SAE International Journal of Commercial Vehicles 7, no. 1 (April 1, 2014): 111–23. http://dx.doi.org/10.4271/2014-01-0615.

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Leung, F. C., M. Welt, R. D. Quesenberry, and X.-Z. Shen. "DNA Fingerprinting and Cloning of Hypervariable Minisatellite Repeats in Salmonids." Canadian Journal of Fisheries and Aquatic Sciences 51, S1 (December 19, 1994): 258–66. http://dx.doi.org/10.1139/f94-312.

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We used heterologous Jeffreys' 33.6 core sequence and microsatellites (CAC)5 and (CA)12 as probes and compared them with probes based on the minisatellite sequences from tilapia (Oreochromis niloticus) and Atlantic salmon (Salmo salar) in fingerprinting assays. DNA fingerprints generated with the Jeffreys' 33.6 core sequence and the microsatellite (CAC)5 and (CA)12 probes showed complex profiles with high background, but DNA fingerprints using the tilapia and Atlantic salmon probes showed clear, less complex, informative, individual-specific DNA fingerprints suitable for analysis. We cloned and sequenced homologous repetitive sequences using a novel approach of creating a chinook salmon (Oncorhynchus tshawytscha) genomic DNA library with enriched low Cot DNA repeats for the development of DNA probes. The four types of repeats identified and sequenced were (CT)n and three Alu-like sequences. We generated DNA fingerprints using one of the minisatellite sequences as a probe. This minisatellite sequence was shown to be species specific because it is abundant in chinook and coho salmon (Oncorhynchus kisutch) genomes, but not in Atlantic salmon. These probes will provide us with the tools to study pedigree and linkage analysis, paternity testing, breeding programs, and the analysis of genetic structure within populations for aquaculture and fisheries research.

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Lu, M., P. Swanson, and J. L. Renfro. "Effect of somatolactin and related hormones on phosphate transport by flounder renal tubule primary cultures." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 268, no. 3 (March 1, 1995): R577—R582. http://dx.doi.org/10.1152/ajpregu.1995.268.3.r577.

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Winter flounder renal proximal tubule primary monolayer cultures mounted in Ussing chambers were used to determine the effect of salmon somatolactin (sSL) on transepithelial Pi and Ca2+ transport. sSL stimulated Pi reabsorption in a dose-dependent manner at physiological levels of the hormone (12.5 ng/ml). Net Pi transport was significantly altered by sSL (200 ng/ml) within 2 h after the initial exposure. Ca2+ fluxes were unchanged by the addition of 200 ng/ml sSL. The sSL-induced Pi reabsorption was abolished by 10 microM H-89, a highly specific protein kinase A inhibitor. Moreover the production and release of adenosine 3',5'-cyclic monophosphate were significantly increased after 1 and 2 h of exposure to sSL. The data indicate that sSL directly stimulates net renal Pi reabsorption by an adenosine 3',5'-cyclic monophosphate-dependent pathway. In addition to sSL, flounder SL and rat prolactin greatly, and salmon growth hormone (2.3 micrograms/ml) slightly, increased net Pi reabsorptive flux, whereas salmon prolactin had no effect.

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Stein, G. J., and P. Múčka. "Theoretical investigation of a linear planar model of a passenger car with seated people." Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering 217, no. 4 (April 1, 2003): 257–68. http://dx.doi.org/10.1243/09544070360613228.

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This paper deals with simulation results of a planar passenger car model, supposed to simulate a ‘standard European saloon car’, with simple linear cushioned seats and a seated human model, which accounts for variation in the body weight. As excitation a short harmonic undulation (so called ‘rollete’) is used, sometimes encountered ahead of traffic-light-controlled road crossings. The simulation results indicate some dependence of the respective frequency response characteristics on the stipulated driver's and passenger's weights. Further large vertical acceleration values at axle hop frequencies are observed, which may under circumstances even exceed the standard gravity acceleration. These decrease with increased traversing velocity, say, above 50 km/h to bearable values. Further it is illustrated that the visibility of lights or signs may be momentarily impaired when accelerating from standstill at a road crossing with a large ‘rollete’ directly before the crossing.

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Ballester Cabo, Rosa. "La apuesta independiente de la animación europea, a través de El pan de la guerra." Con A de animación, no. 8 (March 1, 2018): 112. http://dx.doi.org/10.4995/caa.2018.9651.

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<p>El pan de la guerra (The Breadwinner, Nora Twomey, 2017) es una película irlandesa-canadiense de Cartoon Saloon, que ha tenido como productora ejecutiva a Angelina Jolie y Jordan Peele. La película está basada en la novela bestseller de Deborah Ellis, publicada en 2002, ganadora de varios premios literarios, y que se basó en numerosas entrevistas efectuadas a mujeres y niñas en los campamentos de refugiados de Pakistán y Rusia. El pan de la guerra relata la historia de Parvana, una chica afgana que durante el gobierno de los talibanes debe hacerse pasar por un chico para así mantener a su familia. La película de animación se estrenó en el Toronto International Film Festival de 2017, y ha sido nominada al Oscar® a la Mejor Película de Animación 2018. Para el siguiente artículo hemos contado con una de las diseñadoras y artistas de concepto de Cartoon Saloon, la valenciana Rosa Ballester, que nos explica su proceso de producción en conversación con Nora Twomey (directora del film) y Fabian Erlinghäuser (director de animación).</p>

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Howell, J. P. "The side load distribution on a Rover 800 saloon car under crosswind conditions." Journal of Wind Engineering and Industrial Aerodynamics 60 (April 1996): 139–53. http://dx.doi.org/10.1016/0167-6105(96)00029-3.

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Hillis, A. J. "Multi-input multi-output control of an automotive active engine mounting system." Proceedings of the Institution of Mechanical Engineers, Part D: Journal of Automobile Engineering 225, no. 11 (July 20, 2011): 1492–504. http://dx.doi.org/10.1177/0954407011407701.

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This paper describes the control of automotive active engine mounts, consisting of a conventional passive hydraulic mount and an internal electromagnetic actuator. The actuator generates a force dependent on a control signal from an algorithm implemented in real time. The filtered- x least-mean-square (FXLMS) adaptive filter is applied to a system of two active mounts fitted to a saloon car equipped with a four-cylinder turbo-diesel engine. The steady state and transient performance of the active system is experimentally evaluated, and is found to typically reduce chassis vibration by 50 per cent to 90 per cent under normal driving conditions.

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Boam, D. J. "Energy Audit on a Two-Litre Saloon Car Driving an Ece 15 Cycle from a Cold Start." Proceedings of the Institution of Mechanical Engineers, Part D: Transport Engineering 200, no. 1 (January 1986): 61–67. http://dx.doi.org/10.1243/pime_proc_1986_200_164_02.

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In an effort to identify the aspects of vehicle operation which have most influence on fuel consumption during the ECE 15 driving cycle an energy audit was carried out on a two-litre saloon car driving such a cycle. The most interesting results to emerge were that, in the first cycle, 12 per cent of the fuel passed through the engine either partially or completely unburnt, 8 per cent emerged as useful work, and 60 per cent was used to warm up the engine and transmission, while 10 per cent was rejected in the exhaust gas as heat.

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Pope, Peter E. "The Forgotten Labrador: Kegashka to Blanc-Sablon (review)." Canadian Historical Review 89, no. 2 (2008): 294–95. http://dx.doi.org/10.1353/can.0.0065.

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Anttila, Katja, Anthony P. Farrell, David A. Patterson, Scott G. Hinch, and Erika J. Eliason. "Cardiac SERCA activity in sockeye salmon populations: an adaptive response to migration conditions." Canadian Journal of Fisheries and Aquatic Sciences 76, no. 1 (January 2019): 1–5. http://dx.doi.org/10.1139/cjfas-2018-0334.

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We show that cardiac sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity differs considerably among sockeye salmon (Oncorhynchus nerka) populations. Variability in SERCA activity was significantly correlated with elevation gain and temperature during migration, as well as maximum cardiac stroke volume. Furthermore, because SERCA activity was not lowered during the spawning migration, this aspect of the cardiac contraction machinery is apparently spared during the senescence of these semelparous salmon, likely because it is essential for these fish to complete spawning. Only when spawning had been completed was there a significant reduction in SERCA activity, which was detectable in males at a 25 °C and in females at a 15 °C assay temperature. Hence, we propose that migration conditions act as a strong selective force that has resulted in local adaptation of myocardial SERCA activity among sockeye salmon populations.

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Lacroix, Gilles L. "Plasma ionic composition of the Atlantic salmon (Salmo salar), white sucker (Catostomus commersoni), and alewife (Alosa pseudoharengus) in some acidic rivers of Nova Scotia." Canadian Journal of Zoology 63, no. 10 (October 1, 1985): 2254–61. http://dx.doi.org/10.1139/z85-334.

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Atlantic salmon (Salmo salar) smolts migrating from two acidic rivers (pH 4.9 and 5.2) had high hematocrit levels (> 50%) and low plasma [Cl−] (< 100mequiv. L−1). The hematocrit level was 10% higher and plasma [Na+] was 17% lower in smolts of the more acidic of the two rivers. Salmon parr in rivers of mean pH 5.0, 5.4, and 6.0 over a 7-month period had high hematocrit levels (> 40%) and low plasma [Cl−] (< 125 mequiv. L−1). Plasma [Na+] and [Cl] were both slightly less (~ 5%) and plasma [K+] was higher (> 1.5 times) in parr from the river of pH 5.0 than in those from the other two rivers. Atlantic salmon smolts were more sensitive to low pH (plasma [Na+] 14% less, [Cl] 17% less, and hematocrit level 37% higher) than parr, and parr of the 0+ age-class were more sensitive (plasma [Na+] 9% less) than 1+ parr. Prespawning white suckers (Catostomus commersoni) and alewives (Alosa pseudoharengus) migrating in a river at pH 4.9 had high hematocrit levels and low plasma [Cl−], and alewives (hematocrit, 66%; plasma [Cl], 65 mequiv. L−1) were more severely affected than suckers (hematocrit, 42%; plasma [Cl−], 91 mequiv. L−1). Plasma [Ca2+] in females of both species was not greatly elevated relative to males (female/male [Ca2+] = 1.21 in suckers and 1.14 in alewives), suggesting a possible impairment of calcium metabolism associated with ovarian development. The physiological effects observed in fish inhabiting soft waters (external [Ca2+] < 0.10 mequiv. L−1) at pH levels of about 5.0 generally correlated well with the laboratory "models" of acid exposure in soft water.

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Nuttall, Sarah, and Achille Mbembe. "Afropolis: From Johannesburg." PMLA/Publications of the Modern Language Association of America 122, no. 1 (January 2007): 281–88. http://dx.doi.org/10.1632/pmla.2007.122.1.281.

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On saturdays we sometimes drive across the city to buy fish. We stand at the counter and try to choose fresh fish in a land-locked city—pink salmon, gray sole, yellow kabeljou, silver red roman. Delicious fish, at least six hours from the nearest coast. After that, we're back in the car, on the road. If we take the highway around the city, we see the mine dumps, man-made hills of gold dust, yellow in the winter sun, relics of the old gold mines on which this city was founded, heaving earth to the surface, the debris of wealth extraction. From all around, among and beyond the gold dumps, the city rises.

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DiVietro, Susan, Rebecca Beebe, Meghan Clough, Eric Klein, Garry Lapidus, and DʼAndrea Joseph. "Screening at hair salons." Journal of Trauma and Acute Care Surgery 80, no. 2 (February 2016): 223–28. http://dx.doi.org/10.1097/ta.0000000000000928.

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Liu, Han Wu, Zhao Hui Liu, Hui Xiao Li, and Shao Bo Ping. "Computer Simulation of Hot Stamping Process of DP Steel Car Bumper Chain Based on Dynaform." Applied Mechanics and Materials 178-181 (May 2012): 2877–80. http://dx.doi.org/10.4028/www.scientific.net/amm.178-181.2877.

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Owing to the advantages of weight loss and security, duplex steel plate has been the priority for the saloon car body instead of ordinary one among a majority of engine factories. While there are undesirable phenomena because of its high strength at normal temperature, such as its formability is worsened dramatically, and failure and fracture always occur in the stamping. So hot stamping process must be adopted to make the formability available. Based on the Bumper chain of Beijing Hyundai Reina and taken DP600 high strength steel as research object, this paper analyzes the distributions of stress, strain and thickness changes during the process of sheet metal forming by using eta/DYNAFORM software, simulates the spring-back quantity after hot stamping forming, and the numerical simulation of the temperature field distribution with time during stamping process was done. The result shows that duplex steel plate can meet the performance requirements of automotive chain forming, which offers theory basis for the production of such parts.

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Parenteau, William. "Fish, Law, and Colonialism: The Legal Capture of Salmon in British Columbia (review)." Canadian Historical Review 86, no. 1 (2005): 165–67. http://dx.doi.org/10.1353/can.2005.0082.

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Wagner, GF, EM Jaworski, and DP Radman. "Salmon calcitonin inhibits whole body Ca2+ uptake in young rainbow trout." Journal of Endocrinology 155, no. 3 (December 1, 1997): 459–65. http://dx.doi.org/10.1677/joe.0.1550459.

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Gill Ca2+ transport (GCAT) in fish is regulated by a number of different hormones. Stanniocalcin (STC) from the corpuscles of Stannius (CS) is an inhibitor of GCAT, whereas pituitary-derived prolactin and cortisol stimulate GCAT. Other than this, however, little is known about the effects of other hormones on this important transport process. The role of calcitonin (CT) in calcium homeostasis in fish is still controversial. Whereas many studies have shown significant effects of CT on plasma calcium levels, an equal number of studies have failed to find any correlations between plasma calcium and CT levels in fish. Previous in vitro studies have shown that salmon CT has potent inhibitory effects on GCAT in isolated, perfused fish gill preparations, a finding that has never been corroborated in vivo. Therefore, in this report we examined the effects of salmon CT on whole body 45Ca uptake (as a measure of GCAT) in young rainbow trout. In support of the in vitro findings, we found that CT had significant inhibitory effects on GCAT. In parallel studies, we found that CT had no effects on STC secretion and only modest, stimulatory effects on STC mRNA levels in cultured trout CS cells. These finding suggest that both CT and STC function as negative regulators of GCAT in fish.

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MacEachern, Alan Andrew. "Lost Land of Moses: The Age of Discovery on New Brunswick's Salmon Rivers (review)." Canadian Historical Review 85, no. 1 (2004): 152–53. http://dx.doi.org/10.1353/can.2004.0033.

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Anttila, Katja, Matti Järvilehto, and Satu Mänttäri. "Ca2+ handling and oxidative capacity are greatly impaired in swimming muscles of hatchery-reared versus wild Atlantic salmon (Salmo salar)." Canadian Journal of Fisheries and Aquatic Sciences 65, no. 1 (January 1, 2008): 10–16. http://dx.doi.org/10.1139/f07-142.

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The swimming capacity of fish is strongly associated with muscle performance, although the prerequisites for effective movements have not been fully described at the molecular level. To compare the condition of swimming musculature of hatchery-reared Atlantic salmon (Salmo salar) with that of wild fish, we analyzed the relative level of two excitation–contraction coupling components (i.e., dihydropyridine receptor (DHPR) and ryanodine receptor (RyR)) and the oxidative capacity of muscles with histochemical and Western blot methods. The density of DHPR and RyR was considerably higher in swimming muscles of wild fingerlings (age 0+) (109.8% and 123.3% in red muscle; 128.6% and 186.0% in white muscle, respectively) and yearlings (age 1+) (153.5% and 459.1% in red muscle; 131.2% and 858.4% in white muscle) as compared with those in reared fish. Similar difference was also observed in the oxidative capacity of muscles. Moreover, the oxidative activity correlated positively with the level of DHPR and RyR. Our data indicate that calcium handling, as well as oxidative capacity of swimming muscles of reared salmon, is clearly separable from the corresponding capacities of wild fish. We suggest that the observed alteration is a major contributing factor to the well-documented differences in swimming ability between wild and hatchery-reared salmon.

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Nevitt, G. A., and W. J. Moody. "An electrophysiological characterization of ciliated olfactory receptor cells of the coho salmon Oncorhynchus kisutch." Journal of Experimental Biology 166, no. 1 (May 1, 1992): 1–17. http://dx.doi.org/10.1242/jeb.166.1.1.

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Electrical properties of ciliated olfactory receptor cells isolated from coho salmon (Oncorhynchus kisutch) were studied using the whole-cell mode of the patch-clamp recording technique. 1. Voltage-dependent currents could be separated into two inward and three outward conductances, including a Na+ current, Ca2+ current and three K+ currents. 2. The components of the outward current varied with the life stage of the salmon from which cells had been isolated. In cells isolated from juvenile fish (parr), a Ca(2+)-dependent K+ current dominated the outward current, whereas in cells isolated from older fish (i.e. fish that had undergone smoltification), a transient K+ current became prominent. 3. Differences in response characteristics of outward currents to internal dialysis with cyclic GMP (but not cyclic AMP) were also correlated to the life stage of salmon. Under conditions in which the Ca(2+)-activated current was blocked, relaxation of the outward current was slowed by dialysis with cyclic GMP only in cells isolated from smolts and sea-run fish, but not in those isolated from mature spawners. 4. From these results, we suggest that hormone modulation of olfactory receptor cell development or differentiation may play a role in establishing these differences.

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Uchida, Katsuhisa, Sanae Hasegawa, and Toyoji Kaneko. "Effects of a low-Ca2+ environment on branchial chloride cell morphology in chum salmon fry and immunolocalization of Ca2+-ATPase in chloride cells." Canadian Journal of Zoology 80, no. 6 (June 1, 2002): 1100–1108. http://dx.doi.org/10.1139/z02-090.

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To clarify the involvement of branchial chloride cells in Ca2+ uptake in fresh water (FW), chloride-cell morphology was compared in chum salmon (Oncorhynchus keta) fry acclimated to defined FWs with different Ca2+ concentrations (0, 0.1, and 0.5 mM). Using immunocytochemical staining with an antiserum specific for Na+,K+-ATPase, chloride cells were detected in both filament and lamellar epithelia. The numbers and sizes of chloride cells in the lamellar epithelia were greater in the low-Ca2+ groups (0 and 0.1 mM Ca2+) than in the normal-Ca2+ groups (0.5 mM Ca2+ and normal FW), whereas filament chloride cells were not affected in number or size by the environmental Ca2+ concentration. Electron-microscope observations also revealed that enlarged lamellar chloride cells were more frequently observed in the 0 mM Ca2+ group than in the 0.5 mM Ca2+ group. To obtain morphological evidence for Ca2+ uptake through the branchial epithelia, cellular localization of Ca2+-ATPase was examined with a monoclonal antibody specific for human erythrocyte Ca2+-ATPase. Ca2+-ATPase immunoreactivity was detected in Na+,K+-ATPase-immunoreactive chloride cells in both filament and lamellar epithelia. Using electron-microscope immunocytochemistry, Ca2+-ATPase was found to be localized in the tubular system, which is continuous with the basolateral membrane of chloride cells. These findings indicate that chloride cells in the lamellar epithelia activated by a low Ca2+ concentration may constitute the extra Ca2+ and NaCl uptake capacity required to maintain homeostasis in soft water.

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Haneda, Kosuke, and Yoshitaka Oka. "Selective Modulation of Voltage-Gated Calcium Channels in the Terminal Nerve Gonadotropin-Releasing Hormone Neurons of a Teleost, the Dwarf Gourami (Colisa lalia)." Endocrinology 145, no. 10 (October 1, 2004): 4489–99. http://dx.doi.org/10.1210/en.2004-0353.

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Abstract GnRH neurons in the terminal nerve (TN) have been suggested to function as a neuromodulatory system that regulates long-lasting changes in the animal behavior. Here we examined electrophysiological properties of TN-GnRH neurons in a teleost (dwarf gourami, Colisa lalia), focusing on the voltage-gated Ca2+ channels, which are thought to be coupled to several cellular events such as GnRH release. TN-GnRH neurons showed low-voltage activated (LVA) currents and three types of pharmacologically distinct high-voltage activated (HVA) currents. The L- and N-type currents constituted 30.7 ± 3.1 and 41.0 ± 3.9%, respectively, of HVA currents, which was recorded at the holding potential of −60 mV to inactivate the LVA currents. Although P/Q-type current was small and negligible, R-type current accounted for the remaining 23.6 ± 1.6% of HVA currents. Next we examined the possibility of Ca2+ channel modulation induced by GnRH released in a paracrine/autocrine manner. HVA currents of up to 40% was inhibited by the application of salmon GnRH, which is the same molecular species of GnRH as is synthesized by TN-GnRH neurons themselves. However, salmon GnRH had no measurable effects on LVA currents. The inhibition of HVA currents had a dose dependence (EC50 was 11.5 nm) and type specificity among different HVA currents; N- and R-type currents were preferentially inhibited, but L-type currents had by far lower sensitivity. The physiological significance of different Ca2+ influx pathways, and their paracrine/autocrine regulation mechanisms in TN-GnRH neurons are discussed.

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Coxam, Véronique, Marie-Jeanne Davicco, Denis Durand, Dominique Bauchart, and Jean-Pierre Barlet. "Parathyroid hormone and calcitonin may modulate hepatic IGF-I production in calves." Acta Endocrinologica 123, no. 4 (October 1990): 471–75. http://dx.doi.org/10.1530/acta.0.1230471.

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Abstract. Four young milk-fed calves were fitted with catheters chronically implanted in the mesenteric, portal and hepatic veins and in the hepatic artery, and with electromagnetic blood flow probes in the portal vein and hepatic artery, allowing continuous measurement of IGF-I hepatic production. According to a latin square design, these calves received iv mesenteric infusion of calcium (Ca2+; 5 mg/kg) or synthetic salmon calcitonin (sCT; 1 μg/kg), or synthetic bovine parathyroid hormone (1-34) (bPTH; 1 μg/kg), or solvent alone (1.2 ml/kg). Ca2+, sCT or bPTH had no significant effect on portal vein or hepatic artery blood flow. Hypercalcemia observed following Ca2+ infusion did not significantly modify hepatic IGF-I production. sCT decreased plasma Ca2+, inorganic phosphorus and GH concentrations and hepatic IGF-I production. bPTH induced a slight hypercalcemia and hypophosphatemia. It had no significant effect on plasma GH concentration, but increased significantly hepatic IGF-I production. Thus, the anabolic effects of PTH on bone may be partly mediated through an increase in hepatic IGF-I production.

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Busto Algarín, Antonio Jesús. "La experiencia de animadores españoles creando anime en Japón. Entrevista con Abel Góngora." Con A de animación, no. 9 (March 14, 2019): 58. http://dx.doi.org/10.4995/caa.2019.11332.

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<p>Abel Góngora (Barcelona, 1983) estudió en la Facultad de Bellas Artes de la Universitat Politècnica de València y se especializó en animación. Ha trabajado para prestigiosos estudios de animación de todo el mundo: su primer año laboral lo desarrolla en Irlanda, en Cartoon Saloon; durante cinco años en Francia trabaja para el famoso estudio de coproducción franco-japonesa Ankama, concretamente para la serie Wakfu (2008-); desde entonces, los últimos cinco años hasta la actualidad ha continuado su carrera como supervisor de animación y animador Flash en Science Saru, el estudio del famoso director japonés Masaaki Yuasa, participando en las famosas series anime como Shin Chan (Yoshito Usui, 1992-) y Devilman: Crybaby (Masaaki Yuasa, 2018-), aunque también películas anime como Lu over the Wall (Masaaki Yuasa, 2017) y Night Is Short, Walk on Girl (Masaaki Yuasa, 2017); además de proyectos de Cartoon Network como OK K.O.! Let’s Be Heroes (Ian Jones-Quartey, 2017-), diversos episodios de Hora de Aventuras (Adventure Time, Pendleton Ward, 2010-2018) e incluso otro tipo de encargos para anuncios publicitarios de Disney Channel. En esta entrevista Abel Góngora nos cuenta su apasionante experiencia profesional.</p>

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González Santander, R., M. V. Toledo Lobo, F. J. Martínez Alonso, G. Martínez Cuadrado, M. González-Santander Martínez, and M. Monteagudo. "Calcitonin effects on myoblasts: an ultrastructural study." Proceedings, annual meeting, Electron Microscopy Society of America 53 (August 13, 1995): 910–11. http://dx.doi.org/10.1017/s0424820100140920.

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Several studies have provided detailed descriptions about the effects of calcitonin (CT) on different cell types such as osteoclasts, multinucleate giant cells and trophoblastic cells. CT main role is associated with the maintenance of peripheral Ca2+ homeostasis and it may also modulate free intracellular Ca2+. Myoblasts are particularly sensitive to changes in extra and intracellular Ca2+ concentration, so we have studied CT effects on myotome myoblasts differentiation.Chick embryos from 56-59 h. of incubation (Hamburger and Hamilton stages 16-17) were injected with 0,25 IU of CT dissolved in 125 ul of 0,9 % sterile saline solution (CALSYNAR-50, from Rorer Labs.- synthetic lyophilized salmon CT made by Armour Pharmaceutical Co., Kankakee, Illinois, USA). CT was injected into the ammniotic cavity through a window in the egg shell. Afterwards, the window was closed and the eggs returned into the incubator, until embryos had incubated for 103 h., to reach H.H. stage 24. Some embryos were only injected with saline solution (controls).

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Godiksen, Helene, and Flemming Jessen. "Temperature and Ca2+-dependence of the sarcoplasmic reticulum Ca2+-ATPase in haddock, salmon, rainbow trout and zebra cichlid." Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 133, no. 1 (September 2002): 35–44. http://dx.doi.org/10.1016/s1096-4959(02)00103-3.

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CUSKEY, J., L. DUBOIS, and L. DUBUSKE. "359 Induction of urticaria and angioedema (UR/AE) by synthetic salmon calcitonin (CAL)." Journal of Allergy and Clinical Immunology 87, no. 1 (January 1991): 229. http://dx.doi.org/10.1016/0091-6749(91)91642-7.

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Bjerselius, Rickard, Svante Winberg, Yvonne Winberg, and Katarina Zeipel. "Ca2+ protects olfactory receptor function against acute Cu(II) toxicity in Atlantic salmon." Aquatic Toxicology 25, no. 1-2 (March 1993): 125–37. http://dx.doi.org/10.1016/0166-445x(93)90024-u.

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Lacroix, Gilles L., D. James Gordon, and Dana J. Johnston. "Effects of Low Environmental pH on the Survival, Growth, and ionic Composition of Postemergent Atlantic Salmon (Salmo salar)." Canadian Journal of Fisheries and Aquatic Sciences 42, no. 4 (April 1, 1985): 768–75. http://dx.doi.org/10.1139/f85-098.

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Postemergent Atlantic salmon (Salmo salar) were reared during the early feeding phase in the soft, acidic water of the Westfield River (mean pH 5.0) in Nova Scotia. The fry were held in a flow-through system of tanks in situ and were fed a hatchery diet. Bioassays were also conducted in river water treated with limestone (mean pH 6.1) to provide a control. Cumulative mortality of fry after 30 d in the tanks was 70% at pH 5.0 and only 4% at pH 6.1. Fry in untreated river water were inactive, ingested little food, and lost weight (approximately 25%) during the first 15 d of exposure. Large increases in body [Ca2+] and [Na+] were observed in fry at both pH levels during that time, but the increase in [Ca2+] lagged and that in [Na+] was less in fry at low pH. Deaths occurred 15–30 d after swim-up and dead fry were all severely emaciated, indicating that deaths were probably from starvation. Although there were differences in ionic composition changes in fry held at pH 5.0 compared with control, no major depletion of body ionic reserves occurred relative to initial concentrations. Surviving fry at pH 5.0 developed a tolerance after 25 d and had growth rates, condition factors, and ionic concentrations similar to those of fry in treated water. The mortality of fry during the transition to exogenous feeding, in response to low pH stress in soft water, is probably responsible for reduced recruitment and the decline or loss of salmon stocks in this and other acidic rivers of Nova Scotia.

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Force, T., J. V. Bonventre, M. R. Flannery, A. H. Gorn, M. Yamin, and S. R. Goldring. "A cloned porcine renal calcitonin receptor couples to adenylyl cyclase and phospholipase C." American Journal of Physiology-Renal Physiology 262, no. 6 (June 1, 1992): F1110—F1115. http://dx.doi.org/10.1152/ajprenal.1992.262.6.f1110.

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The signal transduction pathways of the recently cloned porcine kidney calcitonin (CT) receptor were evaluated. This receptor, when stably transfected into MC-3T3 cells, avidly bound salmon CT (SCT) [dissociation constant (Kd) = 4 nM]. Incubation with SCT resulted in a dose-dependent accumulation of adenosine 3',5'-cyclic monophosphate (cAMP) [50% effective concentration (EC50) = 0.02 nM] in transfected cells (referred to as PC-1 cells). Binding kinetics and cAMP dose response relationships were similar to those of the native receptor in LLC-PK1 cells. PC-1 cells also responded to calcitonin gene-related peptide (CGRP), but the EC50 value for cAMP accumulation was more than three orders of magnitude higher than for SCT. Exposure of PC-1 cells to SCT (5 nM to 1 microM) produced a dose-dependent rise in cytosolic free Ca2+ concentration ([Ca2+]i), whereas CGRP did not. The initial rise in [Ca2+]i was not dependent on extracellular Ca2+, suggesting that SCT induced release of Ca2+ from intracellular stores. SCT also increased inositol trisphosphate production in PC-1 cells. In conclusion, the cloned, transfected porcine CT receptor functionally couples to and activates both adenylyl cyclase and phospholipase C. This dual coupling is also a characteristic of the parathyroid hormone receptor, which has significant homology in amino acid sequence with the CT receptor.

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Mokrani, Z., N. Illi, S. Valéro, F. Peyras, V. Soulleihet, and J. P. Auffray. "Épidemiologie des arrêts cardiorespiratoires pris en charge par le Smur de Salon-de-Provence." Journal Européen des Urgences 21 (March 2008): A79. http://dx.doi.org/10.1016/j.jeur.2008.03.320.

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Cabrera-Vega, Elani J., Georgina Alarcón-Ángeles, Martín Gómez Hernández, Gonzalo Campillo-Alvarado, and Marcela Hurtado Y De la Peña. "Design of a DNA-Based Biomaterial by Sol-Gel Method: Application for the Recognition of Albendazole Sulfoxide." MRS Advances 4, no. 64 (2019): 3537–43. http://dx.doi.org/10.1557/adv.2019.417.

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ABSTRACTWe describe the use of immobilized deoxyribonucleic acid (DNA) in a silica matrix as a biorecognition agent for the detection of albendazole sulfoxide (ASU), the primary metabolite of albendazole and a suspected teratogenic and embryotoxic agent. The biomaterial (DNA-containing gel) was synthesized by physical entrapment of salmon sperm in an inorganic silicate matrix by the sol-gel method. Functionality of the DNA-containing gel was evaluated by comparative offline frontal chromatography followed by HPLC analysis of ASU and caffeine (CAF, control) using DNA-containing gel and DNA-free gel. The DNA-containing gel showed relatively high specific retention for ASU, while CAF showed no retention using frontal analysis. We anticipate that the DNA-containing gel can be implemented to identify the interactions of DNA with other active pharmaceutical ingredients (APIs) and their metabolites in a readily available, sensitive and selective frontal chromatography experiment.

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Lock, E. J., R. Ørnsrud, L. Aksnes, F. A. T. Spanings, R. Waagbø, and G. Flik. "The vitamin D receptor and its ligand 1α,25-dihydroxyvitamin D3 in Atlantic salmon (Salmo salar)." Journal of Endocrinology 193, no. 3 (June 2007): 459–71. http://dx.doi.org/10.1677/joe-06-0198.

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Seaward migration of Salmo salar is preceded by preparatory physiological adaptations (parr–smolt transformation) to allow for a switch from freshwater (FW) to seawater (SW), which also means a switch in ambient calcium from hypocalcic (<1 mM Ca2+) to the plasma (~1.25 mM Ca2+) and to strongly hypercalcic (8–12 mM Ca2+). Uptake, storage (skeleton, scales) and excretion of calcium need careful regulation. In fish, the vitamin D endocrine system plays a rather enigmatic role in calcium physiology. Here, we give direct evidence for calcitriol involvement in SW migration. We report the full sequence of the nuclear vitamin D receptor (sVDR0) and two alternatively spliced variants resulting from intron retention (sVDR1 and sVDR2). In FW parr, SW adapting smolts, and in SW adults, plasma concentrations of 25(OH)D3 and 24,25(OH)2D3 did not change significantly. Plasma calcitriol concentrations were lowest in FW parr, doubled during smoltification and remained elevated in SW adults. Increased calcitriol coincided with a twofold decrease in sVDR mRNA levels in gill, intestine, and kidney of FW smolts and SW adults, when compared with parr. Clearly, there was a negative feedback and dynamic response of the vitamin D endocrine system during parr–smolt transformation. The onset of these dynamic changes in FW parr warrants a further search for the endocrines that initiate these changes. We speculate that the vitamin D system plays a crucial role in calcium and phosphorus handling in Atlantic salmon.

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Meghji, Sajeda, Matthew S. Morrison, Brian Henderson, and Timothy R. Arnett. "pH dependence of bone resorption: mouse calvarial osteoclasts are activated by acidosis." American Journal of Physiology-Endocrinology and Metabolism 280, no. 1 (January 1, 2001): E112—E119. http://dx.doi.org/10.1152/ajpendo.2001.280.1.e112.

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We examined the effects of HCO3 − and CO2 acidosis on osteoclast-mediated Ca2+ release from 3-day cultures of neonatal mouse calvaria. Ca2+ release was minimal above pH 7.2 in control cultures but was stimulated strongly by the addition of small amounts of H+ to culture medium (HCO3 − acidosis). For example, addition of 4 meq/l H+ reduced pH from 7.12 to 7.03 and increased Ca2+ release 3.8-fold. The largest stimulatory effects (8- to 11-fold), observed with 15–16 meq/l added H+, were comparable to the maximal Ca2+ release elicited by 1,25-dihydroxyvitamin D3[1,25(OH)2D3; 10 nM], parathyroid hormone (10 nM), or prostaglandin E2 (1 μM); the action of these osteolytic agents was attenuated strongly when ambient pH was increased from ∼7.1 to ∼7.3. CO2 acidosis was a less effective stimulator of Ca2+ release than HCO3 −acidosis over a similar pH range. Ca2+ release stimulated by HCO3 − acidosis was almost completely blocked by salmon calcitonin (20 ng/ml), implying osteoclast involvement. In whole mount preparations of control half-calvaria, ∼400 inactive osteoclast-like multinucleate cells were present; in calvaria exposed to HCO3 − acidosis and to the other osteolytic agents studied, extensive osteoclastic resorption, with perforation of bones, was visible. HCO3 − acidosis, however, reduced numbers of osteoclast-like cells by ∼50%, whereas 1,25(OH)2D3 treatment caused increases of ∼75%. The results suggest that HCO3 − acidosis stimulates resorption by activating mature osteoclasts already present in calvarial bones, rather than by inducing formation of new osteoclasts, and provide further support for the critical role of acid-base balance in controlling osteoclast function.

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Zhao, Wan-Hong, Jie Liu, Bai-Yan Wang, Yin-Xia Chen, Xing-Mei Cao, Yun Yang, Yi-Lin Zhang, et al. "Updated Analysis of a Phase 1, Open-Label Study of LCAR-B38M, a Chimeric Antigen Receptor T Cell Therapy Directed Against B-Cell Maturation Antigen, in Patients with Relapsed/Refractory Multiple Myeloma." Blood 132, Supplement 1 (November 29, 2018): 955. http://dx.doi.org/10.1182/blood-2018-99-110548.

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Abstract LCAR-B38M is a bispecific chimeric antigen receptor T cell (CAR T) therapy directed against B-cell maturation antigen (BCMA). The bi-epitope BCMA binding moieties confer high avidity binding and distinguish LCAR-B38M from other BCMA CAR constructs. Preliminary results of LCAR-B38M in patients (pts) with relapsed/refractory (R/R) multiple myeloma (MM) showed encouraging efficacy and manageable safety (Fan et al.JCO 2017;35:18_suppl LBA3001). Here we present updated safety and efficacy results of the trial. LEGEND-2 (NCT03090659) is an ongoing phase 1, single-arm, open-label multicenter study evaluating LCAR-B38M in pts (18-80 years) with R/R MM. Lymphodepletion was performed using 3 doses of cyclophosphamide 300 mg/m2 on days -5, -4, and -3. Five days after lymphodepletion, LCAR-B38M CAR T cells (median CAR+ cell dose = 0.5x106 cells/kg, [range, 0.07-2x106]) were given in 3 infusions (20, 30, and 50% of total dose). The primary objective is to evaluate the safety of LCAR-B38M CAR T cells; the secondary objective is to evaluate the anti-myeloma response of the treatment. Adverse events (AEs) were graded using the Common Terminology Criteria for AE, v.4.03, and cytokine release syndrome (CRS) was assessed according to Lee et al. (Blood 2014;124:188-95). Response was evaluated using International Myeloma Working Group criteria. This analysis presents data from a single institution. As of June 25, 2018, 57 pts have been infused with LCAR-B38M CAR T cells. The median age was 54 years (range, 27-72), median number of prior therapies was 3 (range, 1-9), and 74% of pts had stage III disease by Durie-Salmon staging. The median duration of follow-up for all pts was 12 months (range, 0.7-25). AEs were reported by all pts; most common were pyrexia (91%), CRS (90%), thrombocytopenia (49%), and leukopenia (47%). Grade ≥3 AEs were reported by 65% of pts; most common were leukopenia (30%), thrombocytopenia (23%), and increased aspartate aminotransferase (21%). CRS was mostly grade 1 (47%) and 2 (35%); 4 pts (7%) had grade 3 cases. Liver function abnormalities were the most common signs of end organ injury among pts with CRS. The median time to onset of CRS was 9 days (range, 1-19). All but 1 CRS events resolved, with a median duration of 9 days (range, 3-57). No clear relationship was demonstrated between dose and CRS; there may be some effect at higher doses, but conclusions are limited by the small number of pts in the grade 3 CRS group (n=4; Figure 1A). Neurotoxicity was observed in 1 pt who had grade 1 aphasia, agitation, and seizure-like activity. The overall response rate (partial response [PR] or better) was 88% (95% confidence interval [CI], 76-95). Complete response (CR) was achieved by 42 pts (74%; 95% CI, 60-85), very good partial response was achieved by 2 pts (4%; 95% CI, 0.4-12), and PR was achieved by 6 pts (11%; 95% CI, 4-22; Figure 1B). Among pts with CR, 39/42 were minimal residual disease (MRD) negative by 8-color flow cytometry. The median time to initial response was 1 month (range, 0.4-4). No clear relationship between LCAR-B38M CAR T cell dose and response was observed (Figure 1C). BCMA expression did not correlate with clinical response. The median duration of response (DOR) was 16 months (95% CI, 12-not reached [NR]). The median DOR for pts who achieved a CR was 22 months (95% CI, 14-NR). At data cutoff, 18 pts (36%) who achieved PR or better progressed. The median progression-free survival (PFS) for all treated pts was 15 months (95% CI, 11-NR); median PFS for pts who achieved CR was 24 months (95% CI, 15-NR). The median overall survival was not reached. Overall, 17 pts died during the study and follow-up period; causes of death were progressive disease (PD; n=14), suicide after PD (n=1), esophagitis (n=1), and pulmonary embolism and acute coronary syndrome (n=1). Peak levels of LCAR-B38M (≥1x104 copies/µg genomic DNA) were observed in a majority of pts with blood samples for analysis (n=32). LCAR-B38M CAR T cells were not detectable in peripheral blood in 71% of pts at 4 months; 5 pts showed CAR T cell persistence up to 10 months. This ongoing first-in-human study has provided initial proof-of-concept that bispecific LCAR-B38M CAR T cells may be a highly effective therapy for R/R MM. LCAR-B38M CAR T cell therapy displayed a manageable safety profile consistent with its known mechanism of action and demonstrated deep and durable responses in pts with R/R MM. A phase 1/2 study of LCAR-B38M in R/R MM has been initiated in the US (NCT03548207). Disclosures Zhuang: Nanjing Legend Biotech: Employment. Fan:Nanjing Legend Biotech: Employment.

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Diociaiuti, Marco, Cecilia Bombelli, Laura Zanetti-Polzi, Marcello Belfiore, Raoul Fioravanti, Gianfranco Macchia, and Cristiano Giordani. "The Interaction between Amyloid Prefibrillar Oligomers of Salmon Calcitonin and a Lipid-Raft Model: Molecular Mechanisms Leading to Membrane Damage, Ca2+-Influx and Neurotoxicity." Biomolecules 10, no. 1 (December 29, 2019): 58. http://dx.doi.org/10.3390/biom10010058.

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To investigate the interaction between amyloid assemblies and “lipid-rafts”, we performed functional and structural experiments on salmon calcitonin (sCT) solutions rich in prefibrillar oligomers, proto- and mature-fibers interacting with liposomes made of monosialoganglioside-GM1 (4%), DPPC (48%) and cholesterol (48%). To focus on the role played by electrostatic forces and considering that sCT is positive and GM1 is negative at physiologic pH, we compared results with those relative to GM1-free liposomes while, to assess membrane fluidity effects, with those relative to cholesterol-free liposomes. We investigated functional effects by evaluating Ca2+-influx in liposomes and viability of HT22-DIFF neurons. Only neurotoxic solutions rich in unstructured prefibrillar oligomers were able to induce Ca2+-influx in the “lipid-rafts” model, suggesting that the two phenomena were correlated. Thus, we investigated protein conformation and membrane modifications occurring during the interaction: circular dichroism showed that “lipid-rafts” fostered the formation of β-structures and energy filtered-transmission electron microscopy that prefibrillar oligomers formed pores, similar to Aβ did. We speculate that electrostatic forces between the positive prefibrillar oligomers and the negative GM1 drive the initial binding while the hydrophobic profile and flexibility of prefibrillar oligomers, together with the membrane fluidity, are responsible for the subsequent pore formation leading to Ca2+-influx and neurotoxicity.

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Boehm, Teresa M. S. A., Christoph J. Klinger, Laura Udraite-Vovk, Christelle Navarro, and Ralf S. Mueller. "Clinical effects of 2 commercially available diets on canine atopic dermatitis." Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 49, no. 04 (August 2021): 256–61. http://dx.doi.org/10.1055/a-1543-4743.

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Abstract Objective Canine atopic dermatitis (CAD) is a common skin disease in dogs. Prior studies were able to determine beneficial effects of essential fatty acids (EFA) on the clinical signs of CAD. The aim of this study was set to evaluate the effects of a newly designed, EFA-enriched diet on the clinical signs of CAD compared to another EFA-enriched diet. Materials and methods In this prospective, randomized, double-blinded study, 31 privately owned dogs with atopic dermatitis received either the control diet (diet A, Hill’s Prescription Diet™ d/d™ Salmon & Rice, n = 17) or the test diet (diet B, Veterinary HPM™ Dermatology Support D1, Virbac, n = 14) for 12 weeks. At the beginning of the study as well as after 4, 8 and 12 weeks, skin lesions and pruritus were evaluated via validated scores and the administered medication was documented. At the same time, the dogs’ coat quality was evaluated via a distinct scoring system. In both groups, a total of 7 dogs each completed the entire study. Results After 12 weeks, there was a mild improvement in lesion scores, pruritus and coat quality with both diets. Clinical relevance In this study, both diets improved the patients’ skin lesions pruritus and coat quality.

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Nevolin, Dmitry G., and Andrey P. Kotelnikov. "To develop and maintain algorithms for the operation of the system of evacuation of people from the saloon of a sinking car." Innotrans, no. 1 (2018): 80–85. http://dx.doi.org/10.20291/2311-164x-2018-1-80-85.

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Darsono, Junianto Tjahjo, and Erni Susana. "Structural Model of Intention to Buy on Purchase Decision Saloon Car In Surabaya: Theory of Planned Behavior Approach and Stimulus Response Theory." IOSR Journal of Business and Management 16, no. 10 (2014): 09–19. http://dx.doi.org/10.9790/487x-161020919.

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Visser, E. J., and P. L. Kwei. "Salmon Calcitonin in the Treatment of Post Herpetic Neuralgia." Anaesthesia and Intensive Care 34, no. 5 (October 2006): 668–71. http://dx.doi.org/10.1177/0310057x0603400505.

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Journal articles on the topic 'CAR SALON'

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